1KHNA

E. coli alkaline phosphatase mutant (d153hd330n) zinc form
Total Genus 142
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
142
Knots found
sequence length
444
structure length
444
Chain Sequence
b'VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Alkaline phosphatase
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 142
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1khnA00
3BDHA 2ZKTA 4KAYA 1E1ZP 3Q3QA 4KAVA 5L0KA 4LQYA 1E33P 5DLWA 2IUCA 2W5XA 1ALHA 1AUKA 4KJGA 1KH7A 1Y6VA 3UN5A 1ANIA 4UPHA 1ELZA 4CYSA 2RH6A 5IJQA 3NVLA 4TN0A 1AJCA 2GSNA 2W8DA 3M8YA 4GTWA 3SZYA 3T02A 3M7VA 1HDHA 4LRFA 3IDDA 4LREA 4ZG9A 4KM4A 1ALJA 3TWZA 1URAA 4ZG7A 4LRAA 1EQJA 2VQRA 1URBA 2W5VA 3NKRA 4MHXA 4CXSA 1EW8A 4FDIA 3UO0A 5C66A 3M8WA 4QAXA 1EW2A 1ALIA 3BDGB 1ED8A 3DYCA 4LR7A 1B8JA 2ANHA 1E2SP 3MK0A 1KHKA 3T00A 4UPIA 5L0BA 3IGZB 5EGHA 4UOOA 3TX0A 1O98A 4GTZA 2QZUA 5GRRA 1ZEDA 3NKNA 1ZEBA 5KXAA 4ZG6A 4CYRA 4YR1A 3E2DA 2GSOA 1AJDA 4UORA 3WBHA 2XRGA 2IUCB 5LIAA 5IJSA 3WAVA 1KHLA 1AJAA 1EW9A 3UN3A 2G9YA 4NWXA 3LXQA 2GLQA 1KH5A 4LRDA 3NKPA 1ED9A 4CXKA 3TG0A 3IGYB 4KJDA 3A52A 5DLVA 5L0EA 3NKMA 4LRBA 4GTYA 3NKQA 5GOVA 5K4PA 3WAXA 1FSUA 1SHNA 3KD8A 4NWJA 3UNYA 5DLTA 3WAYA 1KH9A 4UPLA 2W5QA 1HJKA 5LRMA 4LR2A 2W5SA 3BDFA 3SZZA 3MK1A 3DPCA 1Y7AA 4LR9A 3MK2A 4N7TA 3NKOA 4MIVA 1KHNA 2XR9A 1KH4A 4MY4A 3ED4A 5INHA 4LR8A 1HQAA 4GTXA 4CXUA 3T01A 4LRCA 1P49A 3B5QA 3UN2A 2W8SA 1AJBA 1N2KA 1E3CP 3M8ZA 1N2LA 1O99A 3CMRA 4UPKA 2GA3A 1ELYA 4ZGAA 2W5RA 1ANJA 4B56A 1ALKA 1ZEFA 2GSUA 2D1GA 3WAWA 2IFYA 5AJ9A 5TJ3A 5EGEA 3OT9A 1K7HA 2X98A 4UOPA 5LRNA 1ELXA 2W5TA 4FDJA 1EJJA 1EI6A 2W5WA 3BDGA 5LQQA 5HRTA 1SHQA 1KHJA
chains in the Genus database with same CATH superfamily
3BDHA 2ZKTA 4KAYA 1E1ZP 3Q3QA 4KAVA 5L0KA 4LQYA 1E33P 5DLWA 2IUCA 2W5XA 1ALHA 1AUKA 4KJGA 1KH7A 1Y6VA 3UN5A 1ANIA 4UPHA 1ELZA 4CYSA 2RH6A 5IJQA 3NVLA 4TN0A 1AJCA 2GSNA 2W8DA 3M8YA 4GTWA 3SZYA 3T02A 3M7VA 1HDHA 4LRFA 3IDDA 4LREA 4ZG9A 4KM4A 1ALJA 3TWZA 1URAA 4ZG7A 4LRAA 1EQJA 2VQRA 1URBA 2W5VA 3NKRA 4MHXA 4CXSA 1EW8A 4FDIA 3UO0A 5C66A 3M8WA 4QAXA 1EW2A 1ALIA 3BDGB 1ED8A 3DYCA 4LR7A 1B8JA 2ANHA 1E2SP 3MK0A 1KHKA 3T00A 4UPIA 5L0BA 3IGZB 5EGHA 4UOOA 3TX0A 1O98A 4GTZA 2QZUA 5GRRA 1ZEDA 3NKNA 1ZEBA 5KXAA 4ZG6A 4CYRA 4YR1A 3E2DA 2GSOA 1AJDA 4UORA 3WBHA 2XRGA 2IUCB 5LIAA 5IJSA 3WAVA 1KHLA 1AJAA 1EW9A 3UN3A 2G9YA 4NWXA 3LXQA 2GLQA 1KH5A 4LRDA 3NKPA 1ED9A 4CXKA 3TG0A 3IGYB 4KJDA 3A52A 5DLVA 5L0EA 3NKMA 4LRBA 4GTYA 3NKQA 5GOVA 5K4PA 3WAXA 1FSUA 1SHNA 3KD8A 4NWJA 3UNYA 5DLTA 3WAYA 1KH9A 4UPLA 2W5QA 1HJKA 5LRMA 4LR2A 2W5SA 3BDFA 3SZZA 3MK1A 3DPCA 1Y7AA 4LR9A 3MK2A 4N7TA 3NKOA 4MIVA 1KHNA 2XR9A 1KH4A 4MY4A 3ED4A 5INHA 4LR8A 1HQAA 4GTXA 4CXUA 3T01A 4LRCA 1P49A 3B5QA 3UN2A 2W8SA 1AJBA 1N2KA 1E3CP 3M8ZA 1N2LA 1O99A 3CMRA 4UPKA 2GA3A 1ELYA 4ZGAA 2W5RA 1ANJA 4B56A 1ALKA 1ZEFA 2GSUA 2D1GA 3WAWA 2IFYA 5AJ9A 5TJ3A 5EGEA 3OT9A 1K7HA 2X98A 4UOPA 5LRNA 1ELXA 2W5TA 4FDJA 1EJJA 1EI6A 2W5WA 3BDGA 5LQQA 5HRTA 1SHQA 1KHJA
chains in the Genus database with same CATH topology
3BDHA 2ZKTA 4KAYA 1E1ZP 3Q3QA 4KAVA 5L0KA 4LQYA 1E33P 5DLWA 2IUCA 2W5XA 1ALHA 1AUKA 4KJGA 1KH7A 1Y6VA 3UN5A 1ANIA 4UPHA 1ELZA 4CYSA 2RH6A 5IJQA 3NVLA 4TN0A 1AJCA 2GSNA 2W8DA 3M8YA 4GTWA 3SZYA 3T02A 3M7VA 1HDHA 4LRFA 3IDDA 4LREA 4ZG9A 4KM4A 1ALJA 3TWZA 1URAA 4ZG7A 4LRAA 1EQJA 2VQRA 1URBA 2W5VA 3NKRA 4MHXA 4CXSA 1EW8A 4FDIA 3UO0A 5C66A 3M8WA 4QAXA 1EW2A 1ALIA 3BDGB 1ED8A 3DYCA 4LR7A 1B8JA 2ANHA 1E2SP 3MK0A 1KHKA 3T00A 4UPIA 5L0BA 3IGZB 5EGHA 4UOOA 3TX0A 1O98A 4GTZA 2QZUA 5GRRA 1ZEDA 3NKNA 1ZEBA 5KXAA 4ZG6A 4CYRA 4YR1A 3E2DA 2GSOA 1AJDA 4UORA 3WBHA 2XRGA 2IUCB 5LIAA 5IJSA 3WAVA 1KHLA 1AJAA 1EW9A 3UN3A 2G9YA 4NWXA 3LXQA 2GLQA 1KH5A 4LRDA 3NKPA 1ED9A 4CXKA 3TG0A 3IGYB 4KJDA 3A52A 5DLVA 5L0EA 3NKMA 4LRBA 4GTYA 3NKQA 5GOVA 5K4PA 3WAXA 1FSUA 1SHNA 3KD8A 4NWJA 3UNYA 5DLTA 3WAYA 1KH9A 4UPLA 2W5QA 1HJKA 5LRMA 4LR2A 2W5SA 3BDFA 3SZZA 3MK1A 3DPCA 1Y7AA 4LR9A 3MK2A 4N7TA 3NKOA 4MIVA 1KHNA 2XR9A 1KH4A 4MY4A 3ED4A 5INHA 4LR8A 1HQAA 4GTXA 4CXUA 3T01A 4LRCA 1P49A 3B5QA 3UN2A 2W8SA 1AJBA 1N2KA 1E3CP 3M8ZA 1N2LA 1O99A 3CMRA 4UPKA 2GA3A 1ELYA 4ZGAA 2W5RA 1ANJA 4B56A 1ALKA 1ZEFA 2GSUA 2D1GA 3WAWA 2IFYA 5AJ9A 5TJ3A 5EGEA 3OT9A 1K7HA 2X98A 4UOPA 5LRNA 1ELXA 2W5TA 4FDJA 1EJJA 1EI6A 2W5WA 3BDGA 5LQQA 5HRTA 1SHQA 1KHJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BDH A;  2ZKT A;  4KAY A;  1E1Z P;  3Q3Q A;  4KAV A;  5L0K A;  4LQY A;  1E33 P;  5DLW A;  2IUC A;  2W5X A;  1ALH A;  1AUK A;  4KJG A;  1KH7 A;  1Y6V A;  3UN5 A;  1ANI A;  4UPH A;  1ELZ A;  4CYS A;  2RH6 A;  5IJQ A;  3NVL A;  4TN0 A;  1AJC A;  2GSN A;  2W8D A;  3M8Y A;  4GTW A;  3SZY A;  3T02 A;  3M7V A;  1HDH A;  4LRF A;  3IDD A;  4LRE A;  4ZG9 A;  4KM4 A;  1ALJ A;  3TWZ A;  1URA A;  4ZG7 A;  4LRA A;  1EQJ A;  2VQR A;  1URB A;  2W5V A;  3NKR A;  4MHX A;  4CXS A;  1EW8 A;  4FDI A;  3UO0 A;  5C66 A;  3M8W A;  4QAX A;  1EW2 A;  1ALI A;  3BDG B;  1ED8 A;  3DYC A;  4LR7 A;  1B8J A;  2ANH A;  1E2S P;  3MK0 A;  1KHK A;  3T00 A;  4UPI A;  5L0B A;  3IGZ B;  5EGH A;  4UOO A;  3TX0 A;  1O98 A;  4GTZ A;  2QZU A;  5GRR A;  1ZED A;  3NKN A;  1ZEB A;  5KXA A;  4ZG6 A;  4CYR A;  4YR1 A;  3E2D A;  2GSO A;  1AJD A;  4UOR A;  3WBH A;  2XRG A;  2IUC B;  5LIA A;  5IJS A;  3WAV A;  1KHL A;  1AJA A;  1EW9 A;  3UN3 A;  2G9Y A;  4NWX A;  3LXQ A;  2GLQ A;  1KH5 A;  4LRD A;  3NKP A;  1ED9 A;  4CXK A;  3TG0 A;  3IGY B;  4KJD A;  3A52 A;  5DLV A;  5L0E A;  3NKM A;  4LRB A;  4GTY A;  3NKQ A;  5GOV A;  5K4P A;  3WAX A;  1FSU A;  1SHN A;  3KD8 A;  4NWJ A;  3UNY A;  5DLT A;  3WAY A;  1KH9 A;  4UPL A;  2W5Q A;  1HJK A;  5LRM A;  4LR2 A;  2W5S A;  3BDF A;  3SZZ A;  3MK1 A;  3DPC A;  1Y7A A;  4LR9 A;  3MK2 A;  4N7T A;  3NKO A;  4MIV A;  1KHN A;  2XR9 A;  1KH4 A;  4MY4 A;  3ED4 A;  5INH A;  4LR8 A;  1HQA A;  4GTX A;  4CXU A;  3T01 A;  4LRC A;  1P49 A;  3B5Q A;  3UN2 A;  2W8S A;  1AJB A;  1N2K A;  1E3C P;  3M8Z A;  1N2L A;  1O99 A;  3CMR A;  4UPK A;  2GA3 A;  1ELY A;  4ZGA A;  2W5R A;  1ANJ A;  4B56 A;  1ALK A;  1ZEF A;  2GSU A;  2D1G A;  3WAW A;  2IFY A;  5AJ9 A;  5TJ3 A;  5EGE A;  3OT9 A;  1K7H A;  2X98 A;  4UOP A;  5LRN A;  1ELX A;  2W5T A;  4FDJ A;  1EJJ A;  1EI6 A;  2W5W A;  3BDG A;  5LQQ A;  5HRT A;  1SHQ A;  1KHJ A; 
#chains in the Genus database with same CATH topology
 3BDH A;  2ZKT A;  4KAY A;  1E1Z P;  3Q3Q A;  4KAV A;  5L0K A;  4LQY A;  1E33 P;  5DLW A;  2IUC A;  2W5X A;  1ALH A;  1AUK A;  4KJG A;  1KH7 A;  1Y6V A;  3UN5 A;  1ANI A;  4UPH A;  1ELZ A;  4CYS A;  2RH6 A;  5IJQ A;  3NVL A;  4TN0 A;  1AJC A;  2GSN A;  2W8D A;  3M8Y A;  4GTW A;  3SZY A;  3T02 A;  3M7V A;  1HDH A;  4LRF A;  3IDD A;  4LRE A;  4ZG9 A;  4KM4 A;  1ALJ A;  3TWZ A;  1URA A;  4ZG7 A;  4LRA A;  1EQJ A;  2VQR A;  1URB A;  2W5V A;  3NKR A;  4MHX A;  4CXS A;  1EW8 A;  4FDI A;  3UO0 A;  5C66 A;  3M8W A;  4QAX A;  1EW2 A;  1ALI A;  3BDG B;  1ED8 A;  3DYC A;  4LR7 A;  1B8J A;  2ANH A;  1E2S P;  3MK0 A;  1KHK A;  3T00 A;  4UPI A;  5L0B A;  3IGZ B;  5EGH A;  4UOO A;  3TX0 A;  1O98 A;  4GTZ A;  2QZU A;  5GRR A;  1ZED A;  3NKN A;  1ZEB A;  5KXA A;  4ZG6 A;  4CYR A;  4YR1 A;  3E2D A;  2GSO A;  1AJD A;  4UOR A;  3WBH A;  2XRG A;  2IUC B;  5LIA A;  5IJS A;  3WAV A;  1KHL A;  1AJA A;  1EW9 A;  3UN3 A;  2G9Y A;  4NWX A;  3LXQ A;  2GLQ A;  1KH5 A;  4LRD A;  3NKP A;  1ED9 A;  4CXK A;  3TG0 A;  3IGY B;  4KJD A;  3A52 A;  5DLV A;  5L0E A;  3NKM A;  4LRB A;  4GTY A;  3NKQ A;  5GOV A;  5K4P A;  3WAX A;  1FSU A;  1SHN A;  3KD8 A;  4NWJ A;  3UNY A;  5DLT A;  3WAY A;  1KH9 A;  4UPL A;  2W5Q A;  1HJK A;  5LRM A;  4LR2 A;  2W5S A;  3BDF A;  3SZZ A;  3MK1 A;  3DPC A;  1Y7A A;  4LR9 A;  3MK2 A;  4N7T A;  3NKO A;  4MIV A;  1KHN A;  2XR9 A;  1KH4 A;  4MY4 A;  3ED4 A;  5INH A;  4LR8 A;  1HQA A;  4GTX A;  4CXU A;  3T01 A;  4LRC A;  1P49 A;  3B5Q A;  3UN2 A;  2W8S A;  1AJB A;  1N2K A;  1E3C P;  3M8Z A;  1N2L A;  1O99 A;  3CMR A;  4UPK A;  2GA3 A;  1ELY A;  4ZGA A;  2W5R A;  1ANJ A;  4B56 A;  1ALK A;  1ZEF A;  2GSU A;  2D1G A;  3WAW A;  2IFY A;  5AJ9 A;  5TJ3 A;  5EGE A;  3OT9 A;  1K7H A;  2X98 A;  4UOP A;  5LRN A;  1ELX A;  2W5T A;  4FDJ A;  1EJJ A;  1EI6 A;  2W5W A;  3BDG A;  5LQQ A;  5HRT A;  1SHQ A;  1KHJ A; 
#chains in the Genus database with same CATH homology
 3BDH A;  2ZKT A;  4KAY A;  1E1Z P;  3Q3Q A;  4KAV A;  5L0K A;  4LQY A;  1E33 P;  5DLW A;  2IUC A;  2W5X A;  1ALH A;  1AUK A;  4KJG A;  1KH7 A;  1Y6V A;  3UN5 A;  1ANI A;  4UPH A;  1ELZ A;  4CYS A;  2RH6 A;  5IJQ A;  3NVL A;  4TN0 A;  1AJC A;  2GSN A;  2W8D A;  3M8Y A;  4GTW A;  3SZY A;  3T02 A;  3M7V A;  1HDH A;  4LRF A;  3IDD A;  4LRE A;  4ZG9 A;  4KM4 A;  1ALJ A;  3TWZ A;  1URA A;  4ZG7 A;  4LRA A;  1EQJ A;  2VQR A;  1URB A;  2W5V A;  3NKR A;  4MHX A;  4CXS A;  1EW8 A;  4FDI A;  3UO0 A;  5C66 A;  3M8W A;  4QAX A;  1EW2 A;  1ALI A;  3BDG B;  1ED8 A;  3DYC A;  4LR7 A;  1B8J A;  2ANH A;  1E2S P;  3MK0 A;  1KHK A;  3T00 A;  4UPI A;  5L0B A;  3IGZ B;  5EGH A;  4UOO A;  3TX0 A;  1O98 A;  4GTZ A;  2QZU A;  5GRR A;  1ZED A;  3NKN A;  1ZEB A;  5KXA A;  4ZG6 A;  4CYR A;  4YR1 A;  3E2D A;  2GSO A;  1AJD A;  4UOR A;  3WBH A;  2XRG A;  2IUC B;  5LIA A;  5IJS A;  3WAV A;  1KHL A;  1AJA A;  1EW9 A;  3UN3 A;  2G9Y A;  4NWX A;  3LXQ A;  2GLQ A;  1KH5 A;  4LRD A;  3NKP A;  1ED9 A;  4CXK A;  3TG0 A;  3IGY B;  4KJD A;  3A52 A;  5DLV A;  5L0E A;  3NKM A;  4LRB A;  4GTY A;  3NKQ A;  5GOV A;  5K4P A;  3WAX A;  1FSU A;  1SHN A;  3KD8 A;  4NWJ A;  3UNY A;  5DLT A;  3WAY A;  1KH9 A;  4UPL A;  2W5Q A;  1HJK A;  5LRM A;  4LR2 A;  2W5S A;  3BDF A;  3SZZ A;  3MK1 A;  3DPC A;  1Y7A A;  4LR9 A;  3MK2 A;  4N7T A;  3NKO A;  4MIV A;  1KHN A;  2XR9 A;  1KH4 A;  4MY4 A;  3ED4 A;  5INH A;  4LR8 A;  1HQA A;  4GTX A;  4CXU A;  3T01 A;  4LRC A;  1P49 A;  3B5Q A;  3UN2 A;  2W8S A;  1AJB A;  1N2K A;  1E3C P;  3M8Z A;  1N2L A;  1O99 A;  3CMR A;  4UPK A;  2GA3 A;  1ELY A;  4ZGA A;  2W5R A;  1ANJ A;  4B56 A;  1ALK A;  1ZEF A;  2GSU A;  2D1G A;  3WAW A;  2IFY A;  5AJ9 A;  5TJ3 A;  5EGE A;  3OT9 A;  1K7H A;  2X98 A;  4UOP A;  5LRN A;  1ELX A;  2W5T A;  4FDJ A;  1EJJ A;  1EI6 A;  2W5W A;  3BDG A;  5LQQ A;  5HRT A;  1SHQ A;  1KHJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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