1KHNA

E. coli alkaline phosphatase mutant (d153hd330n) zinc form
Total Genus 142
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
142
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus 142
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1khnA00
4LRBA 4FDIA 2QZUA 3T01A 4ZG9A 1AJDA 2W5QA 4KJDA 4CYSA 1B8JA 1AUKA 4KM4A 5AJ9A 4UPHA 1AJCA 1SHQA 3SZZA 2IFYA 3MK2A 3SZYA 4YR1A 4ZGAA 1ED8A 4MHXA 4CXKA 3A52A 3BDFA 3IGZB 2RH6A 4NWJA 5DLVA 3BDGB 3NKMA 2W5TA 5DLTA 2GSOA 2W8DA 3T00A 3CMRA 3M7VA 5K4PA 4ZG6A 5LRNA 1EI6A 5INHA 5TJ3A 3WAWA 3NKOA 4N7TA 4UPIA 2XRGA 3TX0A 5L0EA 3IDDA 3NKNA 2XR9A 5LQQA 2W5XA 3WAVA 2W8SA 4LRAA 4CXSA 1KHKA 1AJAA 5KXAA 4UORA 1E33P 1URBA 4KJGA 2VQRA 4LR2A 1O99A 3M8ZA 3UN2A 4QAXA 2D1GA 1ED9A 4NWXA 3NKQA 1Y6VA 1ZEDA 4UOOA 1ALHA 1ANIA 4LRCA 1Y7AA 1KH4A 1URAA 2IUCA 3NKRA 3NKPA 4LR8A 3TG0A 1EQJA 1N2LA 1KH9A 4LR9A 1K7HA 4FDJA 3OT9A 4TN0A 1ELZA 2G9YA 2W5VA 5IJSA 1ALKA 1ELYA 1O98A 1E2SP 5IJQA 4B56A 2GSUA 5L0KA 5GOVA 1HQAA 3Q3QA 3LXQA 1AJBA 3M8WA 3MK1A 5C66A 2IUCB 3DYCA 5EGEA 1E1ZP 1ALIA 4LQYA 5L0BA 2GA3A 1E3CP 2ANHA 1EW8A 2GLQA 3B5QA 4LRFA 1ZEFA 1ELXA 3UN3A 1KH5A 3WBHA 4LR7A 3T02A 1EJJA 1SHNA 4GTZA 4UPLA 3DPCA 3TWZA 4MIVA 3MK0A 1HJKA 4GTYA 2W5WA 1EW2A 4CYRA 1FSUA 4LRDA 4UOPA 3ED4A 4KAVA 4CXUA 1EW9A 1ZEBA 1ANJA 1KHLA 1KH7A 1KHJA 2W5SA 2ZKTA 4MY4A 2W5RA 5DLWA 4ZG7A 3UO0A 1P49A 1N2KA 2X98A 3BDGA 3BDHA 3UN5A 4GTXA 5LRMA 5GRRA 3E2DA 3WAYA 2GSNA 1KHNA 4GTWA 1ALJA 3UNYA 5LIAA 4KAYA 3NVLA 4LREA 5HRTA 3KD8A 3WAXA 1HDHA 3M8YA 5EGHA 4UPKA 3IGYB
chains in the Genus database with same CATH superfamily
4LRBA 4FDIA 2QZUA 3T01A 4ZG9A 1AJDA 2W5QA 4KJDA 4CYSA 1B8JA 1AUKA 4KM4A 5AJ9A 4UPHA 1AJCA 1SHQA 3SZZA 2IFYA 3MK2A 3SZYA 4YR1A 4ZGAA 1ED8A 4MHXA 4CXKA 3A52A 3BDFA 3IGZB 2RH6A 4NWJA 5DLVA 3BDGB 3NKMA 2W5TA 5DLTA 2GSOA 2W8DA 3T00A 3CMRA 3M7VA 5K4PA 4ZG6A 5LRNA 1EI6A 5INHA 5TJ3A 3WAWA 3NKOA 4N7TA 4UPIA 2XRGA 3TX0A 5L0EA 3IDDA 3NKNA 2XR9A 5LQQA 2W5XA 3WAVA 2W8SA 4LRAA 4CXSA 1KHKA 1AJAA 5KXAA 4UORA 1E33P 1URBA 4KJGA 2VQRA 4LR2A 1O99A 3M8ZA 3UN2A 4QAXA 2D1GA 1ED9A 4NWXA 3NKQA 1Y6VA 1ZEDA 4UOOA 1ALHA 1ANIA 4LRCA 1Y7AA 1KH4A 1URAA 2IUCA 3NKRA 3NKPA 4LR8A 3TG0A 1EQJA 1N2LA 1KH9A 4LR9A 1K7HA 4FDJA 3OT9A 4TN0A 1ELZA 2G9YA 2W5VA 5IJSA 1ALKA 1ELYA 1O98A 1E2SP 5IJQA 4B56A 2GSUA 5L0KA 5GOVA 1HQAA 3Q3QA 3LXQA 1AJBA 3M8WA 3MK1A 5C66A 2IUCB 3DYCA 5EGEA 1E1ZP 1ALIA 4LQYA 5L0BA 2GA3A 1E3CP 2ANHA 1EW8A 2GLQA 3B5QA 4LRFA 1ZEFA 1ELXA 3UN3A 1KH5A 3WBHA 4LR7A 3T02A 1EJJA 1SHNA 4GTZA 4UPLA 3DPCA 3TWZA 4MIVA 3MK0A 1HJKA 4GTYA 2W5WA 1EW2A 4CYRA 1FSUA 4LRDA 4UOPA 3ED4A 4KAVA 4CXUA 1EW9A 1ZEBA 1ANJA 1KHLA 1KH7A 1KHJA 2W5SA 2ZKTA 4MY4A 2W5RA 5DLWA 4ZG7A 3UO0A 1P49A 1N2KA 2X98A 3BDGA 3BDHA 3UN5A 4GTXA 5LRMA 5GRRA 3E2DA 3WAYA 2GSNA 1KHNA 4GTWA 1ALJA 3UNYA 5LIAA 4KAYA 3NVLA 4LREA 5HRTA 3KD8A 3WAXA 1HDHA 3M8YA 5EGHA 4UPKA 3IGYB
chains in the Genus database with same CATH topology
4LRBA 4FDIA 2QZUA 3T01A 4ZG9A 1AJDA 2W5QA 4KJDA 4CYSA 1B8JA 1AUKA 4KM4A 5AJ9A 4UPHA 1AJCA 1SHQA 3SZZA 2IFYA 3MK2A 3SZYA 4YR1A 4ZGAA 1ED8A 4MHXA 4CXKA 3A52A 3BDFA 3IGZB 2RH6A 4NWJA 5DLVA 3BDGB 3NKMA 2W5TA 5DLTA 2GSOA 2W8DA 3T00A 3CMRA 3M7VA 5K4PA 4ZG6A 5LRNA 1EI6A 5INHA 5TJ3A 3WAWA 3NKOA 4N7TA 4UPIA 2XRGA 3TX0A 5L0EA 3IDDA 3NKNA 2XR9A 5LQQA 2W5XA 3WAVA 2W8SA 4LRAA 4CXSA 1KHKA 1AJAA 5KXAA 4UORA 1E33P 1URBA 4KJGA 2VQRA 4LR2A 1O99A 3M8ZA 3UN2A 4QAXA 2D1GA 1ED9A 4NWXA 3NKQA 1Y6VA 1ZEDA 4UOOA 1ALHA 1ANIA 4LRCA 1Y7AA 1KH4A 1URAA 2IUCA 3NKRA 3NKPA 4LR8A 3TG0A 1EQJA 1N2LA 1KH9A 4LR9A 1K7HA 4FDJA 3OT9A 4TN0A 1ELZA 2G9YA 2W5VA 5IJSA 1ALKA 1ELYA 1O98A 1E2SP 5IJQA 4B56A 2GSUA 5L0KA 5GOVA 1HQAA 3Q3QA 3LXQA 1AJBA 3M8WA 3MK1A 5C66A 2IUCB 3DYCA 5EGEA 1E1ZP 1ALIA 4LQYA 5L0BA 2GA3A 1E3CP 2ANHA 1EW8A 2GLQA 3B5QA 4LRFA 1ZEFA 1ELXA 3UN3A 1KH5A 3WBHA 4LR7A 3T02A 1EJJA 1SHNA 4GTZA 4UPLA 3DPCA 3TWZA 4MIVA 3MK0A 1HJKA 4GTYA 2W5WA 1EW2A 4CYRA 1FSUA 4LRDA 4UOPA 3ED4A 4KAVA 4CXUA 1EW9A 1ZEBA 1ANJA 1KHLA 1KH7A 1KHJA 2W5SA 2ZKTA 4MY4A 2W5RA 5DLWA 4ZG7A 3UO0A 1P49A 1N2KA 2X98A 3BDGA 3BDHA 3UN5A 4GTXA 5LRMA 5GRRA 3E2DA 3WAYA 2GSNA 1KHNA 4GTWA 1ALJA 3UNYA 5LIAA 4KAYA 3NVLA 4LREA 5HRTA 3KD8A 3WAXA 1HDHA 3M8YA 5EGHA 4UPKA 3IGYB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LRB A;  4FDI A;  2QZU A;  3T01 A;  4ZG9 A;  1AJD A;  2W5Q A;  4KJD A;  4CYS A;  1B8J A;  1AUK A;  4KM4 A;  5AJ9 A;  4UPH A;  1AJC A;  1SHQ A;  3SZZ A;  2IFY A;  3MK2 A;  3SZY A;  4YR1 A;  4ZGA A;  1ED8 A;  4MHX A;  4CXK A;  3A52 A;  3BDF A;  3IGZ B;  2RH6 A;  4NWJ A;  5DLV A;  3BDG B;  3NKM A;  2W5T A;  5DLT A;  2GSO A;  2W8D A;  3T00 A;  3CMR A;  3M7V A;  5K4P A;  4ZG6 A;  5LRN A;  1EI6 A;  5INH A;  5TJ3 A;  3WAW A;  3NKO A;  4N7T A;  4UPI A;  2XRG A;  3TX0 A;  5L0E A;  3IDD A;  3NKN A;  2XR9 A;  5LQQ A;  2W5X A;  3WAV A;  2W8S A;  4LRA A;  4CXS A;  1KHK A;  1AJA A;  5KXA A;  4UOR A;  1E33 P;  1URB A;  4KJG A;  2VQR A;  4LR2 A;  1O99 A;  3M8Z A;  3UN2 A;  4QAX A;  2D1G A;  1ED9 A;  4NWX A;  3NKQ A;  1Y6V A;  1ZED A;  4UOO A;  1ALH A;  1ANI A;  4LRC A;  1Y7A A;  1KH4 A;  1URA A;  2IUC A;  3NKR A;  3NKP A;  4LR8 A;  3TG0 A;  1EQJ A;  1N2L A;  1KH9 A;  4LR9 A;  1K7H A;  4FDJ A;  3OT9 A;  4TN0 A;  1ELZ A;  2G9Y A;  2W5V A;  5IJS A;  1ALK A;  1ELY A;  1O98 A;  1E2S P;  5IJQ A;  4B56 A;  2GSU A;  5L0K A;  5GOV A;  1HQA A;  3Q3Q A;  3LXQ A;  1AJB A;  3M8W A;  3MK1 A;  5C66 A;  2IUC B;  3DYC A;  5EGE A;  1E1Z P;  1ALI A;  4LQY A;  5L0B A;  2GA3 A;  1E3C P;  2ANH A;  1EW8 A;  2GLQ A;  3B5Q A;  4LRF A;  1ZEF A;  1ELX A;  3UN3 A;  1KH5 A;  3WBH A;  4LR7 A;  3T02 A;  1EJJ A;  1SHN A;  4GTZ A;  4UPL A;  3DPC A;  3TWZ A;  4MIV A;  3MK0 A;  1HJK A;  4GTY A;  2W5W A;  1EW2 A;  4CYR A;  1FSU A;  4LRD A;  4UOP A;  3ED4 A;  4KAV A;  4CXU A;  1EW9 A;  1ZEB A;  1ANJ A;  1KHL A;  1KH7 A;  1KHJ A;  2W5S A;  2ZKT A;  4MY4 A;  2W5R A;  5DLW A;  4ZG7 A;  3UO0 A;  1P49 A;  1N2K A;  2X98 A;  3BDG A;  3BDH A;  3UN5 A;  4GTX A;  5LRM A;  5GRR A;  3E2D A;  3WAY A;  2GSN A;  1KHN A;  4GTW A;  1ALJ A;  3UNY A;  5LIA A;  4KAY A;  3NVL A;  4LRE A;  5HRT A;  3KD8 A;  3WAX A;  1HDH A;  3M8Y A;  5EGH A;  4UPK A;  3IGY B; 
#chains in the Genus database with same CATH topology
 4LRB A;  4FDI A;  2QZU A;  3T01 A;  4ZG9 A;  1AJD A;  2W5Q A;  4KJD A;  4CYS A;  1B8J A;  1AUK A;  4KM4 A;  5AJ9 A;  4UPH A;  1AJC A;  1SHQ A;  3SZZ A;  2IFY A;  3MK2 A;  3SZY A;  4YR1 A;  4ZGA A;  1ED8 A;  4MHX A;  4CXK A;  3A52 A;  3BDF A;  3IGZ B;  2RH6 A;  4NWJ A;  5DLV A;  3BDG B;  3NKM A;  2W5T A;  5DLT A;  2GSO A;  2W8D A;  3T00 A;  3CMR A;  3M7V A;  5K4P A;  4ZG6 A;  5LRN A;  1EI6 A;  5INH A;  5TJ3 A;  3WAW A;  3NKO A;  4N7T A;  4UPI A;  2XRG A;  3TX0 A;  5L0E A;  3IDD A;  3NKN A;  2XR9 A;  5LQQ A;  2W5X A;  3WAV A;  2W8S A;  4LRA A;  4CXS A;  1KHK A;  1AJA A;  5KXA A;  4UOR A;  1E33 P;  1URB A;  4KJG A;  2VQR A;  4LR2 A;  1O99 A;  3M8Z A;  3UN2 A;  4QAX A;  2D1G A;  1ED9 A;  4NWX A;  3NKQ A;  1Y6V A;  1ZED A;  4UOO A;  1ALH A;  1ANI A;  4LRC A;  1Y7A A;  1KH4 A;  1URA A;  2IUC A;  3NKR A;  3NKP A;  4LR8 A;  3TG0 A;  1EQJ A;  1N2L A;  1KH9 A;  4LR9 A;  1K7H A;  4FDJ A;  3OT9 A;  4TN0 A;  1ELZ A;  2G9Y A;  2W5V A;  5IJS A;  1ALK A;  1ELY A;  1O98 A;  1E2S P;  5IJQ A;  4B56 A;  2GSU A;  5L0K A;  5GOV A;  1HQA A;  3Q3Q A;  3LXQ A;  1AJB A;  3M8W A;  3MK1 A;  5C66 A;  2IUC B;  3DYC A;  5EGE A;  1E1Z P;  1ALI A;  4LQY A;  5L0B A;  2GA3 A;  1E3C P;  2ANH A;  1EW8 A;  2GLQ A;  3B5Q A;  4LRF A;  1ZEF A;  1ELX A;  3UN3 A;  1KH5 A;  3WBH A;  4LR7 A;  3T02 A;  1EJJ A;  1SHN A;  4GTZ A;  4UPL A;  3DPC A;  3TWZ A;  4MIV A;  3MK0 A;  1HJK A;  4GTY A;  2W5W A;  1EW2 A;  4CYR A;  1FSU A;  4LRD A;  4UOP A;  3ED4 A;  4KAV A;  4CXU A;  1EW9 A;  1ZEB A;  1ANJ A;  1KHL A;  1KH7 A;  1KHJ A;  2W5S A;  2ZKT A;  4MY4 A;  2W5R A;  5DLW A;  4ZG7 A;  3UO0 A;  1P49 A;  1N2K A;  2X98 A;  3BDG A;  3BDH A;  3UN5 A;  4GTX A;  5LRM A;  5GRR A;  3E2D A;  3WAY A;  2GSN A;  1KHN A;  4GTW A;  1ALJ A;  3UNY A;  5LIA A;  4KAY A;  3NVL A;  4LRE A;  5HRT A;  3KD8 A;  3WAX A;  1HDH A;  3M8Y A;  5EGH A;  4UPK A;  3IGY B; 
#chains in the Genus database with same CATH homology
 4LRB A;  4FDI A;  2QZU A;  3T01 A;  4ZG9 A;  1AJD A;  2W5Q A;  4KJD A;  4CYS A;  1B8J A;  1AUK A;  4KM4 A;  5AJ9 A;  4UPH A;  1AJC A;  1SHQ A;  3SZZ A;  2IFY A;  3MK2 A;  3SZY A;  4YR1 A;  4ZGA A;  1ED8 A;  4MHX A;  4CXK A;  3A52 A;  3BDF A;  3IGZ B;  2RH6 A;  4NWJ A;  5DLV A;  3BDG B;  3NKM A;  2W5T A;  5DLT A;  2GSO A;  2W8D A;  3T00 A;  3CMR A;  3M7V A;  5K4P A;  4ZG6 A;  5LRN A;  1EI6 A;  5INH A;  5TJ3 A;  3WAW A;  3NKO A;  4N7T A;  4UPI A;  2XRG A;  3TX0 A;  5L0E A;  3IDD A;  3NKN A;  2XR9 A;  5LQQ A;  2W5X A;  3WAV A;  2W8S A;  4LRA A;  4CXS A;  1KHK A;  1AJA A;  5KXA A;  4UOR A;  1E33 P;  1URB A;  4KJG A;  2VQR A;  4LR2 A;  1O99 A;  3M8Z A;  3UN2 A;  4QAX A;  2D1G A;  1ED9 A;  4NWX A;  3NKQ A;  1Y6V A;  1ZED A;  4UOO A;  1ALH A;  1ANI A;  4LRC A;  1Y7A A;  1KH4 A;  1URA A;  2IUC A;  3NKR A;  3NKP A;  4LR8 A;  3TG0 A;  1EQJ A;  1N2L A;  1KH9 A;  4LR9 A;  1K7H A;  4FDJ A;  3OT9 A;  4TN0 A;  1ELZ A;  2G9Y A;  2W5V A;  5IJS A;  1ALK A;  1ELY A;  1O98 A;  1E2S P;  5IJQ A;  4B56 A;  2GSU A;  5L0K A;  5GOV A;  1HQA A;  3Q3Q A;  3LXQ A;  1AJB A;  3M8W A;  3MK1 A;  5C66 A;  2IUC B;  3DYC A;  5EGE A;  1E1Z P;  1ALI A;  4LQY A;  5L0B A;  2GA3 A;  1E3C P;  2ANH A;  1EW8 A;  2GLQ A;  3B5Q A;  4LRF A;  1ZEF A;  1ELX A;  3UN3 A;  1KH5 A;  3WBH A;  4LR7 A;  3T02 A;  1EJJ A;  1SHN A;  4GTZ A;  4UPL A;  3DPC A;  3TWZ A;  4MIV A;  3MK0 A;  1HJK A;  4GTY A;  2W5W A;  1EW2 A;  4CYR A;  1FSU A;  4LRD A;  4UOP A;  3ED4 A;  4KAV A;  4CXU A;  1EW9 A;  1ZEB A;  1ANJ A;  1KHL A;  1KH7 A;  1KHJ A;  2W5S A;  2ZKT A;  4MY4 A;  2W5R A;  5DLW A;  4ZG7 A;  3UO0 A;  1P49 A;  1N2K A;  2X98 A;  3BDG A;  3BDH A;  3UN5 A;  4GTX A;  5LRM A;  5GRR A;  3E2D A;  3WAY A;  2GSN A;  1KHN A;  4GTW A;  1ALJ A;  3UNY A;  5LIA A;  4KAY A;  3NVL A;  4LRE A;  5HRT A;  3KD8 A;  3WAX A;  1HDH A;  3M8Y A;  5EGH A;  4UPK A;  3IGY B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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