1MDUA

Crystal structure of the chicken actin trimer complexed with human gelsolin segment 1 (gs-1)
Total Genus 39
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
39
sequence length
124
structure length
124
Chain Sequence
VVEHPEFLKAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of an F-actin trimer disrupted by gelsolin and implications for the mechanism of severing
pubmed doi rcsb
molecule tags Structural protein
source organism Homo sapiens
molecule keywords gelsolin precursor
total genus 39
structure length 124
sequence length 124
chains with identical sequence D
ec nomenclature
pdb deposition date 2002-08-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00626 Gelsolin Gelsolin repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 1mduA00
5L6WC 2I2QA 1T44G 5KYWB 3EG9A 4CBWG 4CBUG 2VIKA 3CJCG 1D4XG 4KEFA 4PKIG 2FH1A 5KYYA 1T2LA 2MV2A 3DAWB 5KYUA 1J72A 2FF6G 3EH2A 3EH1A 1AHQA 5KYXB 1PCXA 1KCQA 3CIPG 5FAEA 3A5OS 4BEX1 3CJBG 1VFQA 3TU5B 4CBXG 3EGXA 1P8XA 4Z94G 1M2OA 4KEEA 2QTVA 1CNUA 2W0IA 2FH2A 2FGHA 1M2VB 2L72A 3EGDA 1YVNG 1C0FS 1PD1A 2XF1A 5KYWA 1T3YA 1RGIG 1QPVA 2NUPB 3A5NS 1AK6A 3FG7A 2XFAA 3A5MS 2FH3A 5FAFA 2NUTB 1SVRA 4PKGG 1M4JA 3L50A 2MP4A 2FF3A 4PKHB 5IVUA 1MDUA 5KYXA 2MOTA 3FFKA 4KEDA 3EFOB 3FG6A 1AK7A 3A5LS 2D8BA 1NM1G 2LLFA 2KVKA 4S10C 1F7SA 1D0NA 1JHWA 1WNJA 1TVJA 1CFYA 2LXXA 4LIZA 1NMDG 3CI5G 1M2VA 1NPHA 1SVYA 1NLVG 3Q2BA 2LJ8A 5HVKD 3EG9B 1EQYS 1PD0A 2NUPA 1P8ZG 1C0GS 1WFSA 5HVKB 5KYYB 1X67A 5KYUB 2NUTA 1UDMA 5KYNA 1Q8GA 1VKKA 1YAGG 2HD7A 2VILA 1DEJS 1T3XA 1SVQA 1HQZ1 1ESVS 3EFOA 3FFNA 3EGXB 2VACA 5DD2A 1H1VG 1V6FA 1WM4A 5A1MA 1COFA 2FH4A 1Q8XA 1TMWA 3EGDB 4JD2H
chains in the Genus database with same CATH superfamily
5L6WC 2I2QA 1T44G 5KYWB 3EG9A 4CBWG 4CBUG 2VIKA 3CJCG 1D4XG 4KEFA 4PKIG 2FH1A 5KYYA 1T2LA 2MV2A 3DAWB 5KYUA 1J72A 2FF6G 3EH2A 3EH1A 1AHQA 5KYXB 1PCXA 1KCQA 3CIPG 5FAEA 3A5OS 4BEX1 3CJBG 1VFQA 3TU5B 4CBXG 3EGXA 1P8XA 4Z94G 1M2OA 4KEEA 2QTVA 1CNUA 2W0IA 2FH2A 2FGHA 1M2VB 2L72A 3EGDA 1YVNG 1C0FS 1PD1A 2XF1A 5KYWA 1T3YA 1RGIG 1QPVA 2NUPB 3A5NS 1AK6A 3FG7A 2XFAA 3A5MS 2FH3A 5FAFA 2NUTB 1SVRA 4PKGG 1M4JA 3L50A 2MP4A 2FF3A 4PKHB 5IVUA 1MDUA 5KYXA 2MOTA 3FFKA 4KEDA 3EFOB 3FG6A 1AK7A 3A5LS 2D8BA 1NM1G 2LLFA 2KVKA 4S10C 1F7SA 1D0NA 1JHWA 1WNJA 1TVJA 1CFYA 2LXXA 4LIZA 1NMDG 3CI5G 1M2VA 1NPHA 1SVYA 1NLVG 3Q2BA 2LJ8A 5HVKD 3EG9B 1EQYS 1PD0A 2NUPA 1P8ZG 1C0GS 1WFSA 5HVKB 5KYYB 1X67A 5KYUB 2NUTA 1UDMA 5KYNA 3DA7A 1Q8GA 1VKKA 1YAGG 2HD7A 2VILA 1DEJS 1T3XA 1SVQA 1HQZ1 1ESVS 3EFOA 3FFNA 3EGXB 2VACA 5DD2A 1H1VG 1V6FA 1WM4A 5A1MA 1COFA 2FH4A 1Q8XA 1TMWA 3EGDB 4JD2H
chains in the Genus database with same CATH topology
5L6WC 2I2QA 1T44G 5KYWB 3EG9A 4CBWG 4CBUG 2VIKA 3CJCG 1D4XG 4KEFA 4PKIG 2FH1A 5KYYA 1T2LA 2MV2A 3DAWB 5KYUA 1J72A 2FF6G 3EH2A 3EH1A 1AHQA 5KYXB 1PCXA 1KCQA 3CIPG 5FAEA 3A5OS 4BEX1 3CJBG 1VFQA 3TU5B 4CBXG 3EGXA 1P8XA 4Z94G 1M2OA 4KEEA 2QTVA 1CNUA 2W0IA 2FH2A 2FGHA 1M2VB 2L72A 3EGDA 1YVNG 1C0FS 1PD1A 2XF1A 5KYWA 1T3YA 1RGIG 1QPVA 2NUPB 3A5NS 1AK6A 3FG7A 2XFAA 3A5MS 2FH3A 5FAFA 2NUTB 1SVRA 4PKGG 1M4JA 3L50A 2MP4A 2FF3A 4PKHB 5IVUA 1MDUA 5KYXA 2MOTA 3FFKA 4KEDA 3EFOB 3FG6A 1AK7A 3A5LS 2D8BA 1NM1G 2LLFA 2KVKA 4S10C 1F7SA 1D0NA 1JHWA 1WNJA 1TVJA 1CFYA 2LXXA 4LIZA 1NMDG 3CI5G 1M2VA 1NPHA 1SVYA 1NLVG 3Q2BA 2LJ8A 5HVKD 3EG9B 1EQYS 1PD0A 2NUPA 1P8ZG 1C0GS 1WFSA 5HVKB 5KYYB 1X67A 5KYUB 2NUTA 1UDMA 5KYNA 3DA7A 1Q8GA 1VKKA 1YAGG 2HD7A 2VILA 1DEJS 1T3XA 1SVQA 1HQZ1 1ESVS 3EFOA 3FFNA 3EGXB 2VACA 5DD2A 1H1VG 1V6FA 1WM4A 5A1MA 1COFA 2FH4A 1Q8XA 1TMWA 3EGDB 4JD2H
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5L6W C;  2I2Q A;  1T44 G;  5KYW B;  3EG9 A;  4CBW G;  4CBU G;  2VIK A;  3CJC G;  1D4X G;  4KEF A;  4PKI G;  2FH1 A;  5KYY A;  1T2L A;  2MV2 A;  3DAW B;  5KYU A;  1J72 A;  2FF6 G;  3EH2 A;  3EH1 A;  1AHQ A;  5KYX B;  1PCX A;  1KCQ A;  3CIP G;  5FAE A;  3A5O S;  4BEX 1;  3CJB G;  1VFQ A;  3TU5 B;  4CBX G;  3EGX A;  1P8X A;  4Z94 G;  1M2O A;  4KEE A;  2QTV A;  1CNU A;  2W0I A;  2FH2 A;  2FGH A;  1M2V B;  2L72 A;  3EGD A;  1YVN G;  1C0F S;  1PD1 A;  2XF1 A;  5KYW A;  1T3Y A;  1RGI G;  1QPV A;  2NUP B;  3A5N S;  1AK6 A;  3FG7 A;  2XFA A;  3A5M S;  2FH3 A;  5FAF A;  2NUT B;  1SVR A;  4PKG G;  1M4J A;  3L50 A;  2MP4 A;  2FF3 A;  4PKH B;  5IVU A;  1MDU A;  5KYX A;  2MOT A;  3FFK A;  4KED A;  3EFO B;  3FG6 A;  1AK7 A;  3A5L S;  2D8B A;  1NM1 G;  2LLF A;  2KVK A;  4S10 C;  1F7S A;  1D0N A;  1JHW A;  1WNJ A;  1TVJ A;  1CFY A;  2LXX A;  4LIZ A;  1NMD G;  3CI5 G;  1M2V A;  1NPH A;  1SVY A;  1NLV G;  3Q2B A;  2LJ8 A;  5HVK D;  3EG9 B;  1EQY S;  1PD0 A;  2NUP A;  1P8Z G;  1C0G S;  1WFS A;  5HVK B;  5KYY B;  1X67 A;  5KYU B;  2NUT A;  1UDM A;  5KYN A;  1Q8G A;  1VKK A;  1YAG G;  2HD7 A;  2VIL A;  1DEJ S;  1T3X A;  1SVQ A;  1HQZ 1;  1ESV S;  3EFO A;  3FFN A;  3EGX B;  2VAC A;  5DD2 A;  1H1V G;  1V6F A;  1WM4 A;  5A1M A;  1COF A;  2FH4 A;  1Q8X A;  1TMW A;  3EGD B;  4JD2 H; 
#chains in the Genus database with same CATH topology
 5L6W C;  2I2Q A;  1T44 G;  5KYW B;  3EG9 A;  4CBW G;  4CBU G;  2VIK A;  3CJC G;  1D4X G;  4KEF A;  4PKI G;  2FH1 A;  5KYY A;  1T2L A;  2MV2 A;  3DAW B;  5KYU A;  1J72 A;  2FF6 G;  3EH2 A;  3EH1 A;  1AHQ A;  5KYX B;  1PCX A;  1KCQ A;  3CIP G;  5FAE A;  3A5O S;  4BEX 1;  3CJB G;  1VFQ A;  3TU5 B;  4CBX G;  3EGX A;  1P8X A;  4Z94 G;  1M2O A;  4KEE A;  2QTV A;  1CNU A;  2W0I A;  2FH2 A;  2FGH A;  1M2V B;  2L72 A;  3EGD A;  1YVN G;  1C0F S;  1PD1 A;  2XF1 A;  5KYW A;  1T3Y A;  1RGI G;  1QPV A;  2NUP B;  3A5N S;  1AK6 A;  3FG7 A;  2XFA A;  3A5M S;  2FH3 A;  5FAF A;  2NUT B;  1SVR A;  4PKG G;  1M4J A;  3L50 A;  2MP4 A;  2FF3 A;  4PKH B;  5IVU A;  1MDU A;  5KYX A;  2MOT A;  3FFK A;  4KED A;  3EFO B;  3FG6 A;  1AK7 A;  3A5L S;  2D8B A;  1NM1 G;  2LLF A;  2KVK A;  4S10 C;  1F7S A;  1D0N A;  1JHW A;  1WNJ A;  1TVJ A;  1CFY A;  2LXX A;  4LIZ A;  1NMD G;  3CI5 G;  1M2V A;  1NPH A;  1SVY A;  1NLV G;  3Q2B A;  2LJ8 A;  5HVK D;  3EG9 B;  1EQY S;  1PD0 A;  2NUP A;  1P8Z G;  1C0G S;  1WFS A;  5HVK B;  5KYY B;  1X67 A;  5KYU B;  2NUT A;  1UDM A;  5KYN A;  3DA7 A;  1Q8G A;  1VKK A;  1YAG G;  2HD7 A;  2VIL A;  1DEJ S;  1T3X A;  1SVQ A;  1HQZ 1;  1ESV S;  3EFO A;  3FFN A;  3EGX B;  2VAC A;  5DD2 A;  1H1V G;  1V6F A;  1WM4 A;  5A1M A;  1COF A;  2FH4 A;  1Q8X A;  1TMW A;  3EGD B;  4JD2 H; 
#chains in the Genus database with same CATH homology
 5L6W C;  2I2Q A;  1T44 G;  5KYW B;  3EG9 A;  4CBW G;  4CBU G;  2VIK A;  3CJC G;  1D4X G;  4KEF A;  4PKI G;  2FH1 A;  5KYY A;  1T2L A;  2MV2 A;  3DAW B;  5KYU A;  1J72 A;  2FF6 G;  3EH2 A;  3EH1 A;  1AHQ A;  5KYX B;  1PCX A;  1KCQ A;  3CIP G;  5FAE A;  3A5O S;  4BEX 1;  3CJB G;  1VFQ A;  3TU5 B;  4CBX G;  3EGX A;  1P8X A;  4Z94 G;  1M2O A;  4KEE A;  2QTV A;  1CNU A;  2W0I A;  2FH2 A;  2FGH A;  1M2V B;  2L72 A;  3EGD A;  1YVN G;  1C0F S;  1PD1 A;  2XF1 A;  5KYW A;  1T3Y A;  1RGI G;  1QPV A;  2NUP B;  3A5N S;  1AK6 A;  3FG7 A;  2XFA A;  3A5M S;  2FH3 A;  5FAF A;  2NUT B;  1SVR A;  4PKG G;  1M4J A;  3L50 A;  2MP4 A;  2FF3 A;  4PKH B;  5IVU A;  1MDU A;  5KYX A;  2MOT A;  3FFK A;  4KED A;  3EFO B;  3FG6 A;  1AK7 A;  3A5L S;  2D8B A;  1NM1 G;  2LLF A;  2KVK A;  4S10 C;  1F7S A;  1D0N A;  1JHW A;  1WNJ A;  1TVJ A;  1CFY A;  2LXX A;  4LIZ A;  1NMD G;  3CI5 G;  1M2V A;  1NPH A;  1SVY A;  1NLV G;  3Q2B A;  2LJ8 A;  5HVK D;  3EG9 B;  1EQY S;  1PD0 A;  2NUP A;  1P8Z G;  1C0G S;  1WFS A;  5HVK B;  5KYY B;  1X67 A;  5KYU B;  2NUT A;  1UDM A;  5KYN A;  3DA7 A;  1Q8G A;  1VKK A;  1YAG G;  2HD7 A;  2VIL A;  1DEJ S;  1T3X A;  1SVQ A;  1HQZ 1;  1ESV S;  3EFO A;  3FFN A;  3EGX B;  2VAC A;  5DD2 A;  1H1V G;  1V6F A;  1WM4 A;  5A1M A;  1COF A;  2FH4 A;  1Q8X A;  1TMW A;  3EGD B;  4JD2 H; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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