1MSKA

Methionine synthase (activation domain)
Total Genus 110
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
110
sequence length
327
structure length
327
Chain Sequence
TPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIEIYRDETRTHVINVSHHLRQQTEKTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQVEDYARRKGMSVTEVERWLAPNLGYDAD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Methyltransferase
molecule keywords COBALAMIN-DEPENDENT METHIONINE SYNTHASE
publication title The structure of the C-terminal domain of methionine synthase: presenting S-adenosylmethionine for reductive methylation of B12.
pubmed doi rcsb
total genus 110
structure length 327
sequence length 327
ec nomenclature ec 2.1.1.13: Methionine synthase.
pdb deposition date 1996-08-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02965 Met_synt_B12 Vitamin B12 dependent methionine synthase, activation domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.288.10 Mainly Alpha Orthogonal Bundle Cobalamin-dependent Methionine Synthase; domain 2 Cobalamin-dependent Methionine Synthase, domain 2 1mskA02
3.10.196.10 Alpha Beta Roll Cobalamin-dependent Methionine Synthase; domain 1 Vitamin B12-dependent methionine synthase, activation domain 1mskA01
1K7YA 1K98A 1MSKA 3IVAA 3IV9A 3BULA 2O2KA
chains in the Genus database with same CATH superfamily
1K7YA 1K98A 1MSKA 2YJFM 3IVAA 3IV9A 3TPQM 3BULA 2O2KA
chains in the Genus database with same CATH topology
1K7YA 1K98A 1MSKA 3IVAA 3IV9A 3BULA 2O2KA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1K7Y A;  1K98 A;  1MSK A;  3IVA A;  3IV9 A;  3BUL A;  2O2K A; 
#chains in the Genus database with same CATH topology
 1K7Y A;  1K98 A;  1MSK A;  2YJF M;  3IVA A;  3IV9 A;  3TPQ M;  3BUL A;  2O2K A; 
#chains in the Genus database with same CATH homology
 1K7Y A;  1K98 A;  1MSK A;  3IVA A;  3IV9 A;  3BUL A;  2O2K A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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