1MSVA

The s68a s-adenosylmethionine decarboxylase proenzyme processing mutant.
Total Genus 91
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
91
sequence length
325
structure length
319
Chain Sequence
AHFFEGTEKLLEVWFSRQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSEASMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQKIEGFKRLDCQSAMFNDYNFVFTSFAKK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Lyase
molecule keywords S-adenosylmethionine decarboxylase proenzyme
publication title Mechanism of Human S-Adenosylmethionine Decarboxylase Proenzyme Processing as Revealed by the Structure of the S68A Mutant.
pubmed doi rcsb
source organism Homo sapiens
total genus 91
structure length 319
sequence length 325
chains with identical sequence B
ec nomenclature ec 4.1.1.50: Adenosylmethionine decarboxylase.
pdb deposition date 2002-09-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01536 SAM_decarbox Adenosylmethionine decarboxylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.90.10 Alpha Beta 4-Layer Sandwich S-adenosylmethionine decarboxylase S-adenosylmethionine decarboxylase 1msvA00
2IIIA 1JENA 3H0VA 3DZ7A 1I79A 3DZ6A 3EP3A 1JL0A 3EP4A 3EPAA 3DZ4A 1VR7A 3DZ3A 3EP7A 1I7CA 3DZ5A 1MHMA 3EP6A 1I7MA 1I7BA 1MSVA 3EPBA 3EP9A 3DZ2A 3EP8A 5TVOA 1TLUA 1I72A 1TMIA 3EP5A 3H0WA
chains in the Genus database with same CATH superfamily
2IIIA 1JENA 3H0VA 3DZ7A 1I79A 3DZ6A 3EP3A 1JL0A 3EP4A 3EPAA 3DZ4A 1VR7A 3DZ3A 3EP7A 1I7CA 3DZ5A 1MHMA 3EP6A 1I7MA 1I7BA 1MSVA 3EPBA 3EP9A 3DZ2A 3EP8A 5TVOA 1TLUA 1I72A 1TMIA 3EP5A 3H0WA
chains in the Genus database with same CATH topology
3H0WB 2IIIA 1JENA 3H0VA 3DZ7A 3H0VB 1JENB 1I79A 3DZ6A 3EP3A 3DZ6B 3DZ7B 3EP3B 1JL0A 1I79B 3EP4A 3EPAA 3EP4B 3DZ4A 1VR7A 3DZ4B 3EPAB 3DZ3A 3DZ3B 1I7CA 3EP7A 3DZ5A 1I7CB 3EP7B 1MHMA 3DZ5B 3EP6A 1I7MA 1I7BA 1MSVA 3EP6B 1I7MB 3EPBA 3EP9A 1MHMB 3EP9B 1I7BB 3DZ2A 3EP8A 3DZ2B 1TLUA 1I72A 1TMIA 3EP8B 3EPBB 3EP5A 1I72B 5TVOA 5TVOB 3EP5B 3H0WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2III A;  1JEN A;  3H0V A;  3DZ7 A;  1I79 A;  3DZ6 A;  3EP3 A;  1JL0 A;  3EP4 A;  3EPA A;  3DZ4 A;  1VR7 A;  3DZ3 A;  3EP7 A;  1I7C A;  3DZ5 A;  1MHM A;  3EP6 A;  1I7M A;  1I7B A;  1MSV A;  3EPB A;  3EP9 A;  3DZ2 A;  3EP8 A;  5TVO A;  1TLU A;  1I72 A;  1TMI A;  3EP5 A;  3H0W A; 
#chains in the Genus database with same CATH topology
 2III A;  1JEN A;  3H0V A;  3DZ7 A;  1I79 A;  3DZ6 A;  3EP3 A;  1JL0 A;  3EP4 A;  3EPA A;  3DZ4 A;  1VR7 A;  3DZ3 A;  3EP7 A;  1I7C A;  3DZ5 A;  1MHM A;  3EP6 A;  1I7M A;  1I7B A;  1MSV A;  3EPB A;  3EP9 A;  3DZ2 A;  3EP8 A;  5TVO A;  1TLU A;  1I72 A;  1TMI A;  3EP5 A;  3H0W A; 
#chains in the Genus database with same CATH homology
 3H0W B;  2III A;  1JEN A;  3H0V A;  3DZ7 A;  3H0V B;  1JEN B;  1I79 A;  3DZ6 A;  3EP3 A;  3DZ6 B;  3DZ7 B;  3EP3 B;  1JL0 A;  1I79 B;  3EP4 A;  3EPA A;  3EP4 B;  3DZ4 A;  1VR7 A;  3DZ4 B;  3EPA B;  3DZ3 A;  3DZ3 B;  1I7C A;  3EP7 A;  3DZ5 A;  1I7C B;  3EP7 B;  1MHM A;  3DZ5 B;  3EP6 A;  1I7M A;  1I7B A;  1MSV A;  3EP6 B;  1I7M B;  3EPB A;  3EP9 A;  1MHM B;  3EP9 B;  1I7B B;  3DZ2 A;  3EP8 A;  3DZ2 B;  1TLU A;  1I72 A;  1TMI A;  3EP8 B;  3EPB B;  3EP5 A;  1I72 B;  5TVO A;  5TVO B;  3EP5 B;  3H0W A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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