1NPHA

Gelsolin domains 4-6 in active, actin free conformation identifies sites of regulatory calcium ions
Total Genus 89
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
89
sequence length
329
structure length
323
Chain Sequence
DDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNYGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSRDGGQTAPASIRLFQVRASSSGATRAVEVMPKSGALNSNDAFVLKTPSAAYLWVGAGASEAEKTAAQELLKVLRSQHVQVEEGSEPDGFWEALGGKTSYRTSPRLKDKKMDAHPPRLFACSNRIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITVVRQGFEPPSFVGWFLGWDNNYWS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Gelsolin Domains 4-6 in Active, Actin-Free Conformation Identifies Sites of Regulatory Calcium Ions
pubmed doi rcsb
molecule tags Protein binding
source organism Mus musculus
molecule keywords Gelsolin
total genus 89
structure length 323
sequence length 329
ec nomenclature
pdb deposition date 2003-01-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00626 Gelsolin Gelsolin repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 1nphA03
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 1nphA02
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 1nphA01
2MP4A 2FH1A 4PKGG 3EGDB 2FF6G 2KVKA 3EH2A 4CBWG 1NMDG 2FF3A 3EH1A 1WFSA 5KYUA 2LJ8A 2XF1A 3EG9B 5KYXA 1V6FA 1COFA 5KYWA 4BEX1 1UDMA 1M4JA 5IVUA 3CJBG 1J72A 3EGXB 3FG6A 1P8XA 4KEDA 3EGDA 1T3XA 5L6WC 4PKIG 4JD2H 1M2OA 1AHQA 2HD7A 1SVQA 1Q8GA 3EG9A 1M2VA 1C0GS 2I2QA 3DAWB 1SVYA 3A5OS 1X67A 1AK7A 1EQYS 1HQZ1 1AK6A 1C0FS 1NM1G 2NUTB 4Z94G 1F7SA 5DD2A 2VIKA 5FAFA 3EFOB 1D4XG 2VILA 1T3YA 2D8BA 2FH4A 5KYYB 3FFKA 1VFQA 1CNUA 2NUPB 1PD0A 2FH2A 4PKHB 3A5LS 3CIPG 5HVKB 3FFNA 1Q8XA 1CFYA 1KCQA 1TMWA 5KYXB 1NPHA 1JHWA 1PCXA 4KEEA 1TVJA 3EFOA 5KYNA 2QTVA 3EGXA 1P8ZG 3TU5B 1T2LA 3CI5G 2MV2A 1VKKA 4KEFA 1YVNG 3L50A 3FG7A 4LIZA 2XFAA 2FH3A 1NLVG 1SVRA 1RGIG 2NUPA 1H1VG 1YAGG 2VACA 4CBUG 3CJCG 1ESVS 4CBXG 1PD1A 5FAEA 1MDUA 1WNJA 2L72A 1M2VB 5HVKD 4S10C 1D0NA 5KYUB 2LXXA 3Q2BA 1QPVA 2NUTA 3A5MS 5KYWB 1WM4A 3A5NS 5A1MA 2LLFA 2W0IA 5KYYA 1DEJS 2FGHA 2MOTA 1T44G
chains in the Genus database with same CATH superfamily
2MP4A 2FH1A 4PKGG 3EGDB 2FF6G 2KVKA 3EH2A 4CBWG 1NMDG 2FF3A 3EH1A 1WFSA 5KYUA 2LJ8A 2XF1A 3EG9B 5KYXA 1V6FA 1COFA 5KYWA 4BEX1 1UDMA 1M4JA 5IVUA 3CJBG 1J72A 3EGXB 3FG6A 1P8XA 4KEDA 3EGDA 1T3XA 5L6WC 4PKIG 4JD2H 1M2OA 1AHQA 2HD7A 1SVQA 1Q8GA 3EG9A 1M2VA 1C0GS 2I2QA 3DAWB 1SVYA 3A5OS 1X67A 1AK7A 1EQYS 1HQZ1 1AK6A 1C0FS 1NM1G 2NUTB 4Z94G 1F7SA 5DD2A 2VIKA 5FAFA 3EFOB 1D4XG 2VILA 1T3YA 2D8BA 2FH4A 5KYYB 3FFKA 1VFQA 3DA7A 1CNUA 2NUPB 1PD0A 2FH2A 4PKHB 3A5LS 3CIPG 5HVKB 3FFNA 1Q8XA 1CFYA 1KCQA 1TMWA 5KYXB 1NPHA 1JHWA 1PCXA 4KEEA 1TVJA 3EFOA 5KYNA 2QTVA 3EGXA 1P8ZG 3TU5B 1T2LA 3CI5G 2MV2A 1VKKA 4KEFA 1YVNG 3L50A 3FG7A 4LIZA 2XFAA 2FH3A 1NLVG 1SVRA 1RGIG 2NUPA 1H1VG 1YAGG 2VACA 4CBUG 3CJCG 1ESVS 4CBXG 1PD1A 5FAEA 1MDUA 1WNJA 2L72A 1M2VB 5HVKD 4S10C 1D0NA 5KYUB 2LXXA 3Q2BA 1QPVA 2NUTA 3A5MS 5KYWB 1WM4A 3A5NS 5A1MA 2LLFA 2W0IA 5KYYA 1DEJS 2FGHA 2MOTA 1T44G
chains in the Genus database with same CATH topology
2MP4A 2FH1A 4PKGG 3EGDB 2FF6G 2KVKA 3EH2A 4CBWG 1NMDG 2FF3A 3EH1A 1WFSA 5KYUA 2LJ8A 2XF1A 3EG9B 5KYXA 1V6FA 1COFA 5KYWA 4BEX1 1UDMA 1M4JA 5IVUA 3CJBG 1J72A 3EGXB 3FG6A 1P8XA 4KEDA 3EGDA 1T3XA 5L6WC 4PKIG 4JD2H 1M2OA 1AHQA 2HD7A 1SVQA 1Q8GA 3EG9A 1M2VA 1C0GS 2I2QA 3DAWB 1SVYA 3A5OS 1X67A 1AK7A 1EQYS 1HQZ1 1AK6A 1C0FS 1NM1G 2NUTB 4Z94G 1F7SA 5DD2A 2VIKA 5FAFA 3EFOB 1D4XG 2VILA 1T3YA 2D8BA 2FH4A 5KYYB 3FFKA 1VFQA 3DA7A 1CNUA 2NUPB 1PD0A 2FH2A 4PKHB 3A5LS 3CIPG 5HVKB 3FFNA 1Q8XA 1CFYA 1KCQA 1TMWA 5KYXB 1NPHA 1JHWA 1PCXA 4KEEA 1TVJA 3EFOA 5KYNA 2QTVA 3EGXA 1P8ZG 3TU5B 1T2LA 3CI5G 2MV2A 1VKKA 4KEFA 1YVNG 3L50A 3FG7A 4LIZA 2XFAA 2FH3A 1NLVG 1SVRA 1RGIG 2NUPA 1H1VG 1YAGG 2VACA 4CBUG 3CJCG 1ESVS 4CBXG 1PD1A 5FAEA 1MDUA 1WNJA 2L72A 1M2VB 5HVKD 4S10C 1D0NA 5KYUB 2LXXA 3Q2BA 1QPVA 2NUTA 3A5MS 5KYWB 1WM4A 3A5NS 5A1MA 2LLFA 2W0IA 5KYYA 1DEJS 2FGHA 2MOTA 1T44G
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2MP4 A;  2FH1 A;  4PKG G;  3EGD B;  2FF6 G;  2KVK A;  3EH2 A;  4CBW G;  1NMD G;  2FF3 A;  3EH1 A;  1WFS A;  5KYU A;  2LJ8 A;  2XF1 A;  3EG9 B;  5KYX A;  1V6F A;  1COF A;  5KYW A;  4BEX 1;  1UDM A;  1M4J A;  5IVU A;  3CJB G;  1J72 A;  3EGX B;  3FG6 A;  1P8X A;  4KED A;  3EGD A;  1T3X A;  5L6W C;  4PKI G;  4JD2 H;  1M2O A;  1AHQ A;  2HD7 A;  1SVQ A;  1Q8G A;  3EG9 A;  1M2V A;  1C0G S;  2I2Q A;  3DAW B;  1SVY A;  3A5O S;  1X67 A;  1AK7 A;  1EQY S;  1HQZ 1;  1AK6 A;  1C0F S;  1NM1 G;  2NUT B;  4Z94 G;  1F7S A;  5DD2 A;  2VIK A;  5FAF A;  3EFO B;  1D4X G;  2VIL A;  1T3Y A;  2D8B A;  2FH4 A;  5KYY B;  3FFK A;  1VFQ A;  1CNU A;  2NUP B;  1PD0 A;  2FH2 A;  4PKH B;  3A5L S;  3CIP G;  5HVK B;  3FFN A;  1Q8X A;  1CFY A;  1KCQ A;  1TMW A;  5KYX B;  1NPH A;  1JHW A;  1PCX A;  4KEE A;  1TVJ A;  3EFO A;  5KYN A;  2QTV A;  3EGX A;  1P8Z G;  3TU5 B;  1T2L A;  3CI5 G;  2MV2 A;  1VKK A;  4KEF A;  1YVN G;  3L50 A;  3FG7 A;  4LIZ A;  2XFA A;  2FH3 A;  1NLV G;  1SVR A;  1RGI G;  2NUP A;  1H1V G;  1YAG G;  2VAC A;  4CBU G;  3CJC G;  1ESV S;  4CBX G;  1PD1 A;  5FAE A;  1MDU A;  1WNJ A;  2L72 A;  1M2V B;  5HVK D;  4S10 C;  1D0N A;  5KYU B;  2LXX A;  3Q2B A;  1QPV A;  2NUT A;  3A5M S;  5KYW B;  1WM4 A;  3A5N S;  5A1M A;  2LLF A;  2W0I A;  5KYY A;  1DEJ S;  2FGH A;  2MOT A;  1T44 G; 
#chains in the Genus database with same CATH topology
 2MP4 A;  2FH1 A;  4PKG G;  3EGD B;  2FF6 G;  2KVK A;  3EH2 A;  4CBW G;  1NMD G;  2FF3 A;  3EH1 A;  1WFS A;  5KYU A;  2LJ8 A;  2XF1 A;  3EG9 B;  5KYX A;  1V6F A;  1COF A;  5KYW A;  4BEX 1;  1UDM A;  1M4J A;  5IVU A;  3CJB G;  1J72 A;  3EGX B;  3FG6 A;  1P8X A;  4KED A;  3EGD A;  1T3X A;  5L6W C;  4PKI G;  4JD2 H;  1M2O A;  1AHQ A;  2HD7 A;  1SVQ A;  1Q8G A;  3EG9 A;  1M2V A;  1C0G S;  2I2Q A;  3DAW B;  1SVY A;  3A5O S;  1X67 A;  1AK7 A;  1EQY S;  1HQZ 1;  1AK6 A;  1C0F S;  1NM1 G;  2NUT B;  4Z94 G;  1F7S A;  5DD2 A;  2VIK A;  5FAF A;  3EFO B;  1D4X G;  2VIL A;  1T3Y A;  2D8B A;  2FH4 A;  5KYY B;  3FFK A;  1VFQ A;  3DA7 A;  1CNU A;  2NUP B;  1PD0 A;  2FH2 A;  4PKH B;  3A5L S;  3CIP G;  5HVK B;  3FFN A;  1Q8X A;  1CFY A;  1KCQ A;  1TMW A;  5KYX B;  1NPH A;  1JHW A;  1PCX A;  4KEE A;  1TVJ A;  3EFO A;  5KYN A;  2QTV A;  3EGX A;  1P8Z G;  3TU5 B;  1T2L A;  3CI5 G;  2MV2 A;  1VKK A;  4KEF A;  1YVN G;  3L50 A;  3FG7 A;  4LIZ A;  2XFA A;  2FH3 A;  1NLV G;  1SVR A;  1RGI G;  2NUP A;  1H1V G;  1YAG G;  2VAC A;  4CBU G;  3CJC G;  1ESV S;  4CBX G;  1PD1 A;  5FAE A;  1MDU A;  1WNJ A;  2L72 A;  1M2V B;  5HVK D;  4S10 C;  1D0N A;  5KYU B;  2LXX A;  3Q2B A;  1QPV A;  2NUT A;  3A5M S;  5KYW B;  1WM4 A;  3A5N S;  5A1M A;  2LLF A;  2W0I A;  5KYY A;  1DEJ S;  2FGH A;  2MOT A;  1T44 G; 
#chains in the Genus database with same CATH homology
 2MP4 A;  2FH1 A;  4PKG G;  3EGD B;  2FF6 G;  2KVK A;  3EH2 A;  4CBW G;  1NMD G;  2FF3 A;  3EH1 A;  1WFS A;  5KYU A;  2LJ8 A;  2XF1 A;  3EG9 B;  5KYX A;  1V6F A;  1COF A;  5KYW A;  4BEX 1;  1UDM A;  1M4J A;  5IVU A;  3CJB G;  1J72 A;  3EGX B;  3FG6 A;  1P8X A;  4KED A;  3EGD A;  1T3X A;  5L6W C;  4PKI G;  4JD2 H;  1M2O A;  1AHQ A;  2HD7 A;  1SVQ A;  1Q8G A;  3EG9 A;  1M2V A;  1C0G S;  2I2Q A;  3DAW B;  1SVY A;  3A5O S;  1X67 A;  1AK7 A;  1EQY S;  1HQZ 1;  1AK6 A;  1C0F S;  1NM1 G;  2NUT B;  4Z94 G;  1F7S A;  5DD2 A;  2VIK A;  5FAF A;  3EFO B;  1D4X G;  2VIL A;  1T3Y A;  2D8B A;  2FH4 A;  5KYY B;  3FFK A;  1VFQ A;  3DA7 A;  1CNU A;  2NUP B;  1PD0 A;  2FH2 A;  4PKH B;  3A5L S;  3CIP G;  5HVK B;  3FFN A;  1Q8X A;  1CFY A;  1KCQ A;  1TMW A;  5KYX B;  1NPH A;  1JHW A;  1PCX A;  4KEE A;  1TVJ A;  3EFO A;  5KYN A;  2QTV A;  3EGX A;  1P8Z G;  3TU5 B;  1T2L A;  3CI5 G;  2MV2 A;  1VKK A;  4KEF A;  1YVN G;  3L50 A;  3FG7 A;  4LIZ A;  2XFA A;  2FH3 A;  1NLV G;  1SVR A;  1RGI G;  2NUP A;  1H1V G;  1YAG G;  2VAC A;  4CBU G;  3CJC G;  1ESV S;  4CBX G;  1PD1 A;  5FAE A;  1MDU A;  1WNJ A;  2L72 A;  1M2V B;  5HVK D;  4S10 C;  1D0N A;  5KYU B;  2LXX A;  3Q2B A;  1QPV A;  2NUT A;  3A5M S;  5KYW B;  1WM4 A;  3A5N S;  5A1M A;  2LLF A;  2W0I A;  5KYY A;  1DEJ S;  2FGH A;  2MOT A;  1T44 G; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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