1NVWS

Structural evidence for feedback activation by rasgtp of the ras-specific nucleotide exchange factor sos
Total Genus 168
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
168
sequence length
481
structure length
469
Chain Sequence
QMRLPSADVYRFAEPDSEENIIFEEGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS
pubmed doi rcsb
source organism Homo sapiens
molecule tags Signaling protein
molecule keywords Transforming protein p21/H-RAS-1
total genus 168
structure length 469
sequence length 481
ec nomenclature
pdb deposition date 2003-02-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF00617 RasGEF RasGEF domain
S PF00618 RasGEF_N RasGEF N-terminal motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 1nvwS02
1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein; Chain S, domain 1 Son of sevenless (SoS) protein Chain: S domain 1 1nvwS01
4NYMS 4MGZE 4MGKE 4L9MA 4URUS 4F7ZA 4URZS 4US2S 3T6GA 3CF6E 4MGYE 3T6AA 4URXS 4NYJS 2BYVE 4URYS 4NYIS 5CM9A 4US1S 3QXLA 1NVUS 4US0S 1XD4A 5CM8A 2II0A 4JGWA 4URWS 3KSYA 2IJES 4MH0E 1NVXS 1NVWS 1BKDS 4URVS 4MGIE 1XD2C 1NVVS
chains in the Genus database with same CATH superfamily
4NYMS 4MGZE 4MGKE 4L9MA 4URUS 4F7ZA 4URZS 4US2S 3T6GA 3CF6E 4MGYE 3T6AA 4URXS 4NYJS 2BYVE 4URYS 4NYIS 5CM9A 4US1S 3QXLA 1NVUS 4US0S 1XD4A 5CM8A 2II0A 4JGWA 4URWS 3KSYA 2IJES 4MH0E 1NVXS 1NVWS 1BKDS 4URVS 4MGIE 1XD2C 1NVVS
chains in the Genus database with same CATH topology
4NYMS 4MGZE 4MGKE 4L9MA 4URUS 4F7ZA 4URZS 4US2S 3T6GA 3CF6E 4MGYE 3T6AA 4URXS 4NYJS 2BYVE 4URYS 4NYIS 5CM9A 4US1S 3QXLA 1NVUS 4US0S 1XD4A 5CM8A 2II0A 4JGWA 4URWS 3KSYA 2IJES 4MH0E 1NVXS 1NVWS 1BKDS 4URVS 4MGIE 1XD2C 1NVVS
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4NYM S;  4MGZ E;  4MGK E;  4L9M A;  4URU S;  4F7Z A;  4URZ S;  4US2 S;  3T6G A;  3CF6 E;  4MGY E;  3T6A A;  4URX S;  4NYJ S;  2BYV E;  4URY S;  4NYI S;  5CM9 A;  4US1 S;  3QXL A;  1NVU S;  4US0 S;  1XD4 A;  5CM8 A;  2II0 A;  4JGW A;  4URW S;  3KSY A;  2IJE S;  4MH0 E;  1NVX S;  1NVW S;  1BKD S;  4URV S;  4MGI E;  1XD2 C;  1NVV S; 
#chains in the Genus database with same CATH topology
 4NYM S;  4MGZ E;  4MGK E;  4L9M A;  4URU S;  4F7Z A;  4URZ S;  4US2 S;  3T6G A;  3CF6 E;  4MGY E;  3T6A A;  4URX S;  4NYJ S;  2BYV E;  4URY S;  4NYI S;  5CM9 A;  4US1 S;  3QXL A;  1NVU S;  4US0 S;  1XD4 A;  5CM8 A;  2II0 A;  4JGW A;  4URW S;  3KSY A;  2IJE S;  4MH0 E;  1NVX S;  1NVW S;  1BKD S;  4URV S;  4MGI E;  1XD2 C;  1NVV S; 
#chains in the Genus database with same CATH homology
 4NYM S;  4MGZ E;  4MGK E;  4L9M A;  4URU S;  4F7Z A;  4URZ S;  4US2 S;  3T6G A;  3CF6 E;  4MGY E;  3T6A A;  4URX S;  4NYJ S;  2BYV E;  4URY S;  4NYI S;  5CM9 A;  4US1 S;  3QXL A;  1NVU S;  4US0 S;  1XD4 A;  5CM8 A;  2II0 A;  4JGW A;  4URW S;  3KSY A;  2IJE S;  4MH0 E;  1NVX S;  1NVW S;  1BKD S;  4URV S;  4MGI E;  1XD2 C;  1NVV S; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...