1NVXS

Structural evidence for feedback activation by rasgtp of the ras-specific nucleotide exchange factor sos
Total Genus 174
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
174
sequence length
479
structure length
448
Chain Sequence
QMRLPSADVYRFAEPDSEENIIFEEGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS
pubmed doi rcsb
source organism Homo sapiens
molecule tags Signaling protein
molecule keywords Transforming protein p21/H-RAS-1
total genus 174
structure length 448
sequence length 479
ec nomenclature
pdb deposition date 2003-02-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF00617 RasGEF RasGEF domain
S PF00618 RasGEF_N RasGEF N-terminal motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 1nvxS02
1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein; Chain S, domain 1 Son of sevenless (SoS) protein Chain: S domain 1 1nvxS01
1XD2C 4URYS 4US1S 4URXS 4URWS 1NVWS 2II0A 1XD4A 4URUS 4NYJS 3CF6E 4NYIS 4US0S 3T6AA 4MGZE 4URVS 3T6GA 4F7ZA 1BKDS 3QXLA 4MGIE 4L9MA 4MH0E 5CM8A 2IJES 4NYMS 5CM9A 4MGKE 4US2S 3KSYA 1NVVS 1NVUS 1NVXS 4MGYE 4JGWA 4URZS 2BYVE
chains in the Genus database with same CATH superfamily
1XD2C 4URYS 4US1S 4URXS 4URWS 1NVWS 2II0A 1XD4A 4URUS 4NYJS 3CF6E 4NYIS 4US0S 3T6AA 4MGZE 4URVS 3T6GA 4F7ZA 1BKDS 3QXLA 4MGIE 4L9MA 4MH0E 5CM8A 2IJES 4NYMS 5CM9A 4MGKE 4US2S 3KSYA 1NVVS 1NVUS 1NVXS 4MGYE 4JGWA 4URZS 2BYVE
chains in the Genus database with same CATH topology
1XD2C 4URYS 4US1S 4URXS 4URWS 1NVWS 2II0A 1XD4A 4URUS 4NYJS 3CF6E 4NYIS 4US0S 3T6AA 4MGZE 4URVS 3T6GA 4F7ZA 1BKDS 3QXLA 4MGIE 4L9MA 4MH0E 5CM8A 2IJES 4NYMS 5CM9A 4MGKE 4US2S 3KSYA 1NVVS 1NVUS 1NVXS 4MGYE 4JGWA 4URZS 2BYVE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XD2 C;  4URY S;  4US1 S;  4URX S;  4URW S;  1NVW S;  2II0 A;  1XD4 A;  4URU S;  4NYJ S;  3CF6 E;  4NYI S;  4US0 S;  3T6A A;  4MGZ E;  4URV S;  3T6G A;  4F7Z A;  1BKD S;  3QXL A;  4MGI E;  4L9M A;  4MH0 E;  5CM8 A;  2IJE S;  4NYM S;  5CM9 A;  4MGK E;  4US2 S;  3KSY A;  1NVV S;  1NVU S;  1NVX S;  4MGY E;  4JGW A;  4URZ S;  2BYV E; 
#chains in the Genus database with same CATH topology
 1XD2 C;  4URY S;  4US1 S;  4URX S;  4URW S;  1NVW S;  2II0 A;  1XD4 A;  4URU S;  4NYJ S;  3CF6 E;  4NYI S;  4US0 S;  3T6A A;  4MGZ E;  4URV S;  3T6G A;  4F7Z A;  1BKD S;  3QXL A;  4MGI E;  4L9M A;  4MH0 E;  5CM8 A;  2IJE S;  4NYM S;  5CM9 A;  4MGK E;  4US2 S;  3KSY A;  1NVV S;  1NVU S;  1NVX S;  4MGY E;  4JGW A;  4URZ S;  2BYV E; 
#chains in the Genus database with same CATH homology
 1XD2 C;  4URY S;  4US1 S;  4URX S;  4URW S;  1NVW S;  2II0 A;  1XD4 A;  4URU S;  4NYJ S;  3CF6 E;  4NYI S;  4US0 S;  3T6A A;  4MGZ E;  4URV S;  3T6G A;  4F7Z A;  1BKD S;  3QXL A;  4MGI E;  4L9M A;  4MH0 E;  5CM8 A;  2IJE S;  4NYM S;  5CM9 A;  4MGK E;  4US2 S;  3KSY A;  1NVV S;  1NVU S;  1NVX S;  4MGY E;  4JGW A;  4URZ S;  2BYV E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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