1O7DD

The structure of the bovine lysosomal a-mannosidase suggests a novel mechanism for low ph activation
Total Genus 59
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
59
sequence length
272
structure length
269
Chain Sequence
RDLVIQNEYLRARFDPNTGLLMELENLLLLPVRQAFYWYNASTGNNLSSQASGAYIFRPNQNKPLFVSHWAQTHLVKASLVQEVHQNFSAWCSQVVRLYPRQRHLELEWTVGPIPVGDGWGKEVISRFDTALATRGLFYTDSNGREILERRRNYRPTWKLNQTEPVAGNYYPVNSRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRLLKDDARGVGEPLNKEGSGLWVRGRHLVLLDKKETAAARHRLQAEMEVLAPQVVLAQG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Structure of Bovine Lysosomal Alpha-Mannosidase Suggests a Novel Mechanism for Low-Ph Activation
pubmed doi rcsb
molecule keywords Lysosomal alpha-mannosidase
molecule tags Hydrolase
total genus 59
structure length 269
sequence length 272
ec nomenclature ec 3.2.1.24: Alpha-mannosidase.
pdb deposition date 2002-10-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF07748 Glyco_hydro_38C Glycosyl hydrolases family 38 C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.98.30 Mainly Beta Distorted Sandwich Beta-galactosidase; Chain A, domain 5 Golgi alpha-mannosidase II; domain 4 1o7dD01
3CZNA 4K35A 3BUQA 5KBPA 3D52A 3D4YA 3BVWA 3DX3A 3BUIA 3BLBA 3CV5A 3DX2A 3EJTA 3EJUA 1R33A 1QX1A 1TQSA 3EJQA 2WYIA 3EJPA 3DX1A 1HXKA 1PS3A 2F7RA 1HWWA 3LVTA 3BVTA 3BVUA 3CZSA 3BUBA 1R34A 1QWUA 2FYVA 1TQUA 4K3AA 3D50A 2F18A 3BVVA 3EJSA 1TQTA 3DX4A 3EJRA 1HTYA 2F7PA 1TQWA 3DDGA 2OW6A 1TQVA 2F7QA 3BUDA 2OW7A 3D4ZA 3DX0A 3DDFA 2F1BA 2ALWA 3BVXA 2WYHA 1O7DD 1QWNA 3BUPA 2F1AA 2F7OA 3D51A
chains in the Genus database with same CATH superfamily
2CQSA 1JZ7A 4FNRA 1NS7A 4KFFA 2XN2A 3CV5A 1R33A 2OQEC 2WCOA 3DYMA 1D6ZA 4DUWA 1PS3A 3T2QA 3KIIA 5CA3A 3E7JA 1NSMA 1W6GA 2JKPA 1X1HA 2F7QA 4BTWA 2YFNA 1IQYA 3ACTA 3T0DA 3D52A 2WVXB 1RWHA 2WW3A 3ACSA 3IAQA 1HN1A 3Q1NA 1QAKA 2CG1A 3BVUA 4BTXA 4K3AA 3D50A 3WVFA 4KFEA 1Z45A 2C11A 5A1AA 1J0NA 1L7JA 4DUXA 4OJZA 1JYNA 4BTYA 1D6UA 3VD9A 2JKAA 1NKGA 1N7RA 2XSGA 1SIHA 1N7OA 3T09A 1IVWA 1F4HA 3DCDA 3I3EA 1OJNA 4FNSA 4BZHA 1MN0A 1MMUA 1K1YA 3X42A 1HTYA 1WMOA 1K1XA 5E1QA 1HN0A 1JOVA 1CB8A 3BLBA 1QX1A 2PNCA 2HTAA 1PU4A 3D3IA 4TTGA 3LOYA 1H54A 1IVVA 2ZL8A 3DECA 2BT3A 1EKMA 1TQTA 3S4DA 2Y74A 2X03A 1PX4A 2WW1A 2CFKA 3J7HA 3DX0A 3OS7A 1QWNA 1LF9A 1N7NA 2D1WA 3NJVA 3BVWA 3DX2A 3K5TA 3T0UA 1ULVA 2WDAA 2WO0A 2CISA 1C82A 1TQUA 3N9HA 2RDYA 4EV2A 4DUVA 4OK4A 1X1IA 3DYOA 1TQVA 1YGAA 4MMHA 2CFWA 3NJXA 3D51A 1JYVA 2CQTA 2WVXA 1EGUA 3BUQA 3AMOB 4NEIA 1WMNA 1MMYA 3QFZA 2WYIA 1OJMA 3VSNA 1HXKA 1HWWA 1JZ5A 1V7VA 3CZSA 2CFGA 1RKYA 3IAPA 1TQWA 2OW6A 1MMZA 3OB8A 1OACA 2XN1A 3W7TA 1F9GA 1W3YA 1YQ2A 2F7RA 4KTRA 2YFOA 5KBPA 3RSYA 1JZ2A 2OOVC 3X41A 1UI7A 1SNZA 3T0AA 1QWUA 1R34A 1N7PA 3BGAA 1SPUA 3WA2X 1HMWA 3X3YA 4EV5A 3HIGA 2F1BA 3WIRA 1LXKA 2CWUA 3S4AA 3BUIA 3EJUA 1NS0A 2EABA 2WOFA 1US1A 3TY1A 1RW9A 2FUTA 2FUQA 1RJOA 1KSIA 1NSZA 3WA3A 3DX4A 3IMHA 1JZ3A 3MUZ1 3I3DA 4UFCA 3BUPA 2W0QA 2CIRA 3AFLA 2WVYA 3SX1A 2Y73A 2WZSA 3BS6A 1N7QA 1NSXA 2BRWA 3HIIA 3VD7A 3VSMA 3BUDA 3DDFA 4MMIA 2OQEA 1AVLA 2CFLA 2F7OA 3AMOA 2JKEA 1AVKA 3E80A 2XN0A 1PX3A 1UI8A 4BZFA 3S4CA 1NSVA 1JYXA 3QDEA 3K25A 3HI7A 3BVTA 1RWGA 1W2ZA 4FNPA 3EJRA 3W7WA 1I8QA 2OOVA 3WFAA 3A0OA 3ECQA 5JMFA 3T08A 3T0BA 2EADA 3QFYA 5JMDA 1NSSA 2E2VA 2ZXQA 2CFDA 1F4AA 4OK2A 1HM2A 2WGQA 1UG9A 1W5ZA 1LURA 3LVTA 1J0MA 2E2TA 2EACA 2CWVA 4KTPA 1NS8A 2XHNA 1LXMA 1NS4A 4FNQA 1IU7A 2CWTA 1NSRA 1JRQA 3MUY1 3X3ZA 2E22A 1SO0A 1LVNA 3NBJA 3S4BA 2HTBA 1W7CA 3BUBA 1HMUA 3EJSA 3X40A 1DYUA 1W4NA 2E24A 3A24A 1O7DD 3NBBA 2EAEA 2C10A 1RWFA 3VDCA 3CZNA 3DYPA 3T2OA 3MI6A 2D73A 3MPHA 1TQSA 2ZQ0A 2CG0A 3SXXA 4FNVA 1WMPA 2FYVA 3NREA 3VD4A 1K1WA 2F7PA 1V7WA 2Q1FA 3KN4A 1JYWA 3E1F1 4BZGA 5GW7A 3MWXA 1V7XA 1OJPA 2BRVX 4K35A 3RRSA 3CZJA 1OJOA 3EJQA 3VDAA 3W7SA 3DX1A 2YX9A 1HM3A 4AQ0A 2CIQA 1IVUA 1AV4A 1N9EA 1LOHA 3MV01 4J5TA 1TXKA 3WIQA 3DDGA 2WW0A 3SEPA 3VD5A 2ALWA 4RNLA 1F1SA 3AFJA 1A2VA 1JZ8A 1IVXA 1RWCA 3DX3A 3PGBA 1LF6A 1JZ4A 3ALAA 3EJPA 1NSUA 1DP0A 1D6YA 1L7KA 3X3XA 1SIIA 2F18A 2BRPA 1TU5A 3W7UA 3D4ZA 1RWAA 1MMXA 4FNUA 2WYHA 4FNTA 2F1AA 1NS2A 3D4YA 1W6CA 3EJTA 3T2PA 1X1JA 3I3BA 3W7XA 3OBAA 2E2UA 1QALA 1IQXA 3BLCA 4KFDA 1JZ6A 3BVVA 2WOHA 4BZEA 3VDBA 2WVZA 2OW7A 3QG0A 3VD3A 1QAFA 3BVXA 3MV11 2WW2A
chains in the Genus database with same CATH topology
3CZNA 4K35A 3BUQA 5KBPA 3D52A 3D4YA 3BVWA 3DX3A 3BUIA 3BLBA 3CV5A 3DX2A 3EJTA 3EJUA 1R33A 1QX1A 1TQSA 3EJQA 2WYIA 3EJPA 3DX1A 1HXKA 1PS3A 2F7RA 1HWWA 3LVTA 3BVTA 3BVUA 3CZSA 3BUBA 1R34A 1QWUA 2FYVA 1TQUA 4K3AA 3D50A 2F18A 3BVVA 3EJSA 1TQTA 3DX4A 3EJRA 1HTYA 2F7PA 1TQWA 3DDGA 2OW6A 1TQVA 2F7QA 3BUDA 2OW7A 3D4ZA 3DX0A 3DDFA 2F1BA 2ALWA 3BVXA 2WYHA 1O7DD 1QWNA 3BUPA 2F1AA 2F7OA 3D51A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CZN A;  4K35 A;  3BUQ A;  5KBP A;  3D52 A;  3D4Y A;  3BVW A;  3DX3 A;  3BUI A;  3BLB A;  3CV5 A;  3DX2 A;  3EJT A;  3EJU A;  1R33 A;  1QX1 A;  1TQS A;  3EJQ A;  2WYI A;  3EJP A;  3DX1 A;  1HXK A;  1PS3 A;  2F7R A;  1HWW A;  3LVT A;  3BVT A;  3BVU A;  3CZS A;  3BUB A;  1R34 A;  1QWU A;  2FYV A;  1TQU A;  4K3A A;  3D50 A;  2F18 A;  3BVV A;  3EJS A;  1TQT A;  3DX4 A;  3EJR A;  1HTY A;  2F7P A;  1TQW A;  3DDG A;  2OW6 A;  1TQV A;  2F7Q A;  3BUD A;  2OW7 A;  3D4Z A;  3DX0 A;  3DDF A;  2F1B A;  2ALW A;  3BVX A;  2WYH A;  1O7D D;  1QWN A;  3BUP A;  2F1A A;  2F7O A;  3D51 A; 
#chains in the Genus database with same CATH topology
 2CQS A;  1JZ7 A;  4FNR A;  1NS7 A;  4KFF A;  2XN2 A;  3CV5 A;  1R33 A;  2OQE C;  2WCO A;  3DYM A;  1D6Z A;  4DUW A;  1PS3 A;  3T2Q A;  3KII A;  5CA3 A;  3E7J A;  1NSM A;  1W6G A;  2JKP A;  1X1H A;  2F7Q A;  4BTW A;  2YFN A;  1IQY A;  3ACT A;  3T0D A;  3D52 A;  2WVX B;  1RWH A;  2WW3 A;  3ACS A;  3IAQ A;  1HN1 A;  3Q1N A;  1QAK A;  2CG1 A;  3BVU A;  4BTX A;  4K3A A;  3D50 A;  3WVF A;  4KFE A;  1Z45 A;  2C11 A;  5A1A A;  1J0N A;  1L7J A;  4DUX A;  4OJZ A;  1JYN A;  4BTY A;  1D6U A;  3VD9 A;  2JKA A;  1NKG A;  1N7R A;  2XSG A;  1SIH A;  1N7O A;  3T09 A;  1IVW A;  1F4H A;  3DCD A;  3I3E A;  1OJN A;  4FNS A;  4BZH A;  1MN0 A;  1MMU A;  1K1Y A;  3X42 A;  1HTY A;  1WMO A;  1K1X A;  5E1Q A;  1HN0 A;  1JOV A;  1CB8 A;  3BLB A;  1QX1 A;  2PNC A;  2HTA A;  1PU4 A;  3D3I A;  4TTG A;  3LOY A;  1H54 A;  1IVV A;  2ZL8 A;  3DEC A;  2BT3 A;  1EKM A;  1TQT A;  3S4D A;  2Y74 A;  2X03 A;  1PX4 A;  2WW1 A;  2CFK A;  3J7H A;  3DX0 A;  3OS7 A;  1QWN A;  1LF9 A;  1N7N A;  2D1W A;  3NJV A;  3BVW A;  3DX2 A;  3K5T A;  3T0U A;  1ULV A;  2WDA A;  2WO0 A;  2CIS A;  1C82 A;  1TQU A;  3N9H A;  2RDY A;  4EV2 A;  4DUV A;  4OK4 A;  1X1I A;  3DYO A;  1TQV A;  1YGA A;  4MMH A;  2CFW A;  3NJX A;  3D51 A;  1JYV A;  2CQT A;  2WVX A;  1EGU A;  3BUQ A;  3AMO B;  4NEI A;  1WMN A;  1MMY A;  3QFZ A;  2WYI A;  1OJM A;  3VSN A;  1HXK A;  1HWW A;  1JZ5 A;  1V7V A;  3CZS A;  2CFG A;  1RKY A;  3IAP A;  1TQW A;  2OW6 A;  1MMZ A;  3OB8 A;  1OAC A;  2XN1 A;  3W7T A;  1F9G A;  1W3Y A;  1YQ2 A;  2F7R A;  4KTR A;  2YFO A;  5KBP A;  3RSY A;  1JZ2 A;  2OOV C;  3X41 A;  1UI7 A;  1SNZ A;  3T0A A;  1QWU A;  1R34 A;  1N7P A;  3BGA A;  1SPU A;  3WA2 X;  1HMW A;  3X3Y A;  4EV5 A;  3HIG A;  2F1B A;  3WIR A;  1LXK A;  2CWU A;  3S4A A;  3BUI A;  3EJU A;  1NS0 A;  2EAB A;  2WOF A;  1US1 A;  3TY1 A;  1RW9 A;  2FUT A;  2FUQ A;  1RJO A;  1KSI A;  1NSZ A;  3WA3 A;  3DX4 A;  3IMH A;  1JZ3 A;  3MUZ 1;  3I3D A;  4UFC A;  3BUP A;  2W0Q A;  2CIR A;  3AFL A;  2WVY A;  3SX1 A;  2Y73 A;  2WZS A;  3BS6 A;  1N7Q A;  1NSX A;  2BRW A;  3HII A;  3VD7 A;  3VSM A;  3BUD A;  3DDF A;  4MMI A;  2OQE A;  1AVL A;  2CFL A;  2F7O A;  3AMO A;  2JKE A;  1AVK A;  3E80 A;  2XN0 A;  1PX3 A;  1UI8 A;  4BZF A;  3S4C A;  1NSV A;  1JYX A;  3QDE A;  3K25 A;  3HI7 A;  3BVT A;  1RWG A;  1W2Z A;  4FNP A;  3EJR A;  3W7W A;  1I8Q A;  2OOV A;  3WFA A;  3A0O A;  3ECQ A;  5JMF A;  3T08 A;  3T0B A;  2EAD A;  3QFY A;  5JMD A;  1NSS A;  2E2V A;  2ZXQ A;  2CFD A;  1F4A A;  4OK2 A;  1HM2 A;  2WGQ A;  1UG9 A;  1W5Z A;  1LUR A;  3LVT A;  1J0M A;  2E2T A;  2EAC A;  2CWV A;  4KTP A;  1NS8 A;  2XHN A;  1LXM A;  1NS4 A;  4FNQ A;  1IU7 A;  2CWT A;  1NSR A;  1JRQ A;  3MUY 1;  3X3Z A;  2E22 A;  1SO0 A;  1LVN A;  3NBJ A;  3S4B A;  2HTB A;  1W7C A;  3BUB A;  1HMU A;  3EJS A;  3X40 A;  1DYU A;  1W4N A;  2E24 A;  3A24 A;  1O7D D;  3NBB A;  2EAE A;  2C10 A;  1RWF A;  3VDC A;  3CZN A;  3DYP A;  3T2O A;  3MI6 A;  2D73 A;  3MPH A;  1TQS A;  2ZQ0 A;  2CG0 A;  3SXX A;  4FNV A;  1WMP A;  2FYV A;  3NRE A;  3VD4 A;  1K1W A;  2F7P A;  1V7W A;  2Q1F A;  3KN4 A;  1JYW A;  3E1F 1;  4BZG A;  5GW7 A;  3MWX A;  1V7X A;  1OJP A;  2BRV X;  4K35 A;  3RRS A;  3CZJ A;  1OJO A;  3EJQ A;  3VDA A;  3W7S A;  3DX1 A;  2YX9 A;  1HM3 A;  4AQ0 A;  2CIQ A;  1IVU A;  1AV4 A;  1N9E A;  1LOH A;  3MV0 1;  4J5T A;  1TXK A;  3WIQ A;  3DDG A;  2WW0 A;  3SEP A;  3VD5 A;  2ALW A;  4RNL A;  1F1S A;  3AFJ A;  1A2V A;  1JZ8 A;  1IVX A;  1RWC A;  3DX3 A;  3PGB A;  1LF6 A;  1JZ4 A;  3ALA A;  3EJP A;  1NSU A;  1DP0 A;  1D6Y A;  1L7K A;  3X3X A;  1SII A;  2F18 A;  2BRP A;  1TU5 A;  3W7U A;  3D4Z A;  1RWA A;  1MMX A;  4FNU A;  2WYH A;  4FNT A;  2F1A A;  1NS2 A;  3D4Y A;  1W6C A;  3EJT A;  3T2P A;  1X1J A;  3I3B A;  3W7X A;  3OBA A;  2E2U A;  1QAL A;  1IQX A;  3BLC A;  4KFD A;  1JZ6 A;  3BVV A;  2WOH A;  4BZE A;  3VDB A;  2WVZ A;  2OW7 A;  3QG0 A;  3VD3 A;  1QAF A;  3BVX A;  3MV1 1;  2WW2 A; 
#chains in the Genus database with same CATH homology
 3CZN A;  4K35 A;  3BUQ A;  5KBP A;  3D52 A;  3D4Y A;  3BVW A;  3DX3 A;  3BUI A;  3BLB A;  3CV5 A;  3DX2 A;  3EJT A;  3EJU A;  1R33 A;  1QX1 A;  1TQS A;  3EJQ A;  2WYI A;  3EJP A;  3DX1 A;  1HXK A;  1PS3 A;  2F7R A;  1HWW A;  3LVT A;  3BVT A;  3BVU A;  3CZS A;  3BUB A;  1R34 A;  1QWU A;  2FYV A;  1TQU A;  4K3A A;  3D50 A;  2F18 A;  3BVV A;  3EJS A;  1TQT A;  3DX4 A;  3EJR A;  1HTY A;  2F7P A;  1TQW A;  3DDG A;  2OW6 A;  1TQV A;  2F7Q A;  3BUD A;  2OW7 A;  3D4Z A;  3DX0 A;  3DDF A;  2F1B A;  2ALW A;  3BVX A;  2WYH A;  1O7D D;  1QWN A;  3BUP A;  2F1A A;  2F7O A;  3D51 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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