1O99A

Crystal structure of the s62a mutant of phosphoglycerate mutase from bacillus stearothermophilus complexed with 2-phosphoglycerate
Total Genus 195
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
195
Knots found
sequence length
509
structure length
509
Chain Sequence
SKKPVALIILDGFALRDETYGNAVAQANKPNFDRYWNEYPHTTLKACGEAVGLPEGQMGNAEVGHLNIGAGRIVYQSLTRINIAIREGEFDRNETFLAAMNHVKQHGTSLHLFGLLSDGGVHSHIHHLYALLRLAAKEGVKRVYIHGFLDGRDVGPQTAPQYIKELQEKIKEYGVGEIATLSGRYYSMDRDKRWDRVEKAYRAMVYGEGPTYRDPLECIEDSYKHGIYDEFVLPSVIVREDGRPVATIQDNDAIIFYNFRPDRAIQISNTFTNEDFREFDRGPKHPKHLFFVCLTHFSETVAGYVAFKPTNLDNTIGEVLSQHGLRQLRIAETEKYPHVTFFMSGGREEEFPGEDRILINSPKVPTYDLKPEMSAYEVTDALLKEIEADKYDAIILNYANPDMVGHSGKLEPTIKAVEAVDECLGKVVDAILAKGGIAIITADHGNADEVLTPDGKPQTAHTTNPVPVIVTKKGIKLRDGGILGDLAPTMLDLLGLPQPKEMTGKSLIV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Insights Into the Catalytic Mechanism of Cofactor-Independent Phosphoglycerate Mutase from X-Ray Crystallography, Simulated Dynamics and Molecular Modeling
pubmed doi rcsb
molecule tags Isomerase
source organism Bacillus stearothermophilus
molecule keywords 2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE
total genus 195
structure length 509
sequence length 509
other databases KnotProt 2.0: S +31
ec nomenclature ec 5.4.2.12: Phosphoglycerate mutase (2,3-diphosphoglycerate-independent).
pdb deposition date 2002-12-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01676 Metalloenzyme Metalloenzyme superfamily
A PF06415 iPGM_N BPG-independent PGAM N-terminus (iPGM_N)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1o99A02
3.40.1450.10 Alpha Beta 3-Layer(aba) Sandwich 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain BPG-independent phosphoglycerate mutase, domain B 1o99A01
1AUKA 3WAYA 5IJSA 5HRTA 1KHLA 4LRFA 4LRAA 1N2LA 1AJBA 3Q3QA 3MK2A 3WAVA 3TG0A 4GTYA 4NWJA 3M8YA 3CMRA 3TX0A 3BDGA 5L0EA 5EGEA 1ELZA 1FSUA 3UN5A 3UN2A 3LXQA 1KH7A 4CYRA 3M8ZA 1ELYA 3UNYA 4YR1A 1ED9A 5GOVA 3UN3A 2W5TA 4UOOA 2RH6A 3E2DA 4LQYA 2X98A 4KAVA 5IJQA 5KXAA 3B5QA 1SHNA 1E33P 3DPCA 5TJ3A 1KHJA 1ZEDA 2IFYA 3WAWA 3NKNA 1ANJA 4LRBA 2QZUA 4FDJA 4GTXA 2ZKTA 5EGHA 3BDFA 3SZYA 4CYSA 1EW9A 1ALKA 2VQRA 4LRCA 1K7HA 2IUCB 3MK1A 2GA3A 1EQJA 4LR9A 1EW2A 4LREA 3DYCA 4N7TA 5DLTA 4LRDA 4ZG7A 4B56A 4UOPA 1Y7AA 2W8SA 3A52A 3NKPA 1AJAA 1URAA 2GSUA 3NKRA 4QAXA 1AJCA 1ED8A 1ZEFA 1AJDA 1KH5A 4MHXA 3IGZB 2GSNA 3IGYB 5K4PA 3UO0A 1HQAA 4UORA 3M7VA 3IDDA 5L0BA 3TWZA 1URBA 4LR8A 3T01A 4KJGA 5DLVA 5LRNA 1Y6VA 1KH9A 1ANIA 4MY4A 3BDGB 2W5QA 3MK0A 3WAXA 5DLWA 2ANHA 3OT9A 4ZG9A 3T02A 3SZZA 2XR9A 1ZEBA 1EW8A 3ED4A 3T00A 1E2SP 1KH4A 2W5XA 1EI6A 4LR2A 4CXSA 4KM4A 4KJDA 5L0KA 3BDHA 1ALIA 1O99A 1P49A 5AJ9A 1N2KA 3NKMA 1HJKA 2GSOA 2W5VA 4ZG6A 4NWXA 1KHNA 4ZGAA 1O98A 4FDIA 2G9YA 5LRMA 1ELXA 4TN0A 3KD8A 4KAYA 3WBHA 3NKOA 3M8WA 2D1GA 1B8JA 2W5RA 3NKQA 2GLQA 2IUCA 5LQQA 4UPHA 4UPIA 4CXKA 1E3CP 1E1ZP 1ALHA 4LR7A 3NVLA 2XRGA 1SHQA 4UPKA 2W5WA 2W8DA 4MIVA 5INHA 5LIAA 4GTZA 4UPLA 5GRRA 1KHKA 1HDHA 4CXUA 1ALJA 1EJJA 4GTWA 2W5SA 5C66A
chains in the Genus database with same CATH superfamily
1AUKA 3WAYA 5IJSA 5HRTA 1KHLA 4LRFA 4LRAA 1N2LA 1AJBA 3Q3QA 3MK2A 3WAVA 3TG0A 4GTYA 4NWJA 3M8YA 3CMRA 3TX0A 3BDGA 5L0EA 5EGEA 1ELZA 1FSUA 3UN5A 3UN2A 3LXQA 1KH7A 4CYRA 3M8ZA 1ELYA 3UNYA 4YR1A 1ED9A 5GOVA 3UN3A 2W5TA 4UOOA 2RH6A 3E2DA 4LQYA 2X98A 4KAVA 5IJQA 5KXAA 3B5QA 1SHNA 1E33P 3DPCA 5TJ3A 1KHJA 1ZEDA 2IFYA 3WAWA 3NKNA 1ANJA 4LRBA 2QZUA 4FDJA 4GTXA 2ZKTA 5EGHA 3BDFA 3SZYA 4CYSA 1EW9A 1ALKA 2VQRA 4LRCA 1K7HA 2IUCB 3MK1A 2GA3A 1EQJA 4LR9A 1EW2A 4LREA 3DYCA 4N7TA 5DLTA 4LRDA 4ZG7A 4B56A 4UOPA 1Y7AA 2W8SA 3A52A 3NKPA 1AJAA 1URAA 2GSUA 3NKRA 4QAXA 1AJCA 1ED8A 1ZEFA 1AJDA 1KH5A 4MHXA 3IGZB 2GSNA 3IGYB 5K4PA 3UO0A 1HQAA 4UORA 3M7VA 3IDDA 5L0BA 3TWZA 1URBA 4LR8A 3T01A 4KJGA 5DLVA 5LRNA 1Y6VA 1KH9A 1ANIA 4MY4A 3BDGB 2W5QA 3MK0A 3WAXA 5DLWA 2ANHA 3OT9A 4ZG9A 3T02A 3SZZA 2XR9A 1ZEBA 1EW8A 3ED4A 3T00A 1E2SP 1KH4A 2W5XA 1EI6A 4LR2A 4CXSA 4KM4A 4KJDA 5L0KA 3BDHA 1ALIA 1O99A 1P49A 5AJ9A 1N2KA 3NKMA 1HJKA 2GSOA 2W5VA 4ZG6A 4NWXA 1KHNA 4ZGAA 1O98A 4FDIA 2G9YA 5LRMA 1ELXA 4TN0A 3KD8A 4KAYA 3WBHA 3NKOA 3M8WA 2D1GA 1B8JA 2W5RA 3NKQA 2GLQA 2IUCA 5LQQA 4UPHA 4UPIA 4CXKA 1E3CP 1E1ZP 1ALHA 4LR7A 3NVLA 2XRGA 1SHQA 4UPKA 2W5WA 2W8DA 4MIVA 5INHA 5LIAA 4GTZA 4UPLA 5GRRA 1KHKA 1HDHA 4CXUA 1ALJA 1EJJA 4GTWA 2W5SA 5C66A
chains in the Genus database with same CATH topology
1AUKA 3WAYA 5IJSA 5HRTA 1KHLA 4LRFA 4LRAA 1N2LA 1AJBA 3Q3QA 3MK2A 3WAVA 3TG0A 4GTYA 4NWJA 3M8YA 3CMRA 3TX0A 3BDGA 5L0EA 5EGEA 1ELZA 1FSUA 3UN5A 3UN2A 3LXQA 1KH7A 4CYRA 3M8ZA 1ELYA 3UNYA 4YR1A 1ED9A 5GOVA 3UN3A 2W5TA 4UOOA 2RH6A 3E2DA 4LQYA 2X98A 4KAVA 5IJQA 5KXAA 3B5QA 1SHNA 1E33P 3DPCA 5TJ3A 1KHJA 1ZEDA 2IFYA 3WAWA 3NKNA 1ANJA 4LRBA 2QZUA 4FDJA 4GTXA 2ZKTA 5EGHA 3BDFA 3SZYA 4CYSA 1EW9A 1ALKA 2VQRA 4LRCA 1K7HA 2IUCB 3MK1A 2GA3A 1EQJA 4LR9A 1EW2A 4LREA 3DYCA 4N7TA 5DLTA 4LRDA 4ZG7A 4B56A 4UOPA 1Y7AA 2W8SA 3A52A 3NKPA 1AJAA 1URAA 2GSUA 3NKRA 4QAXA 1AJCA 1ED8A 1ZEFA 1AJDA 1KH5A 4MHXA 3IGZB 2GSNA 3IGYB 5K4PA 3UO0A 1HQAA 4UORA 3M7VA 3IDDA 5L0BA 3TWZA 1URBA 4LR8A 3T01A 4KJGA 5DLVA 5LRNA 1Y6VA 1KH9A 1ANIA 4MY4A 3BDGB 2W5QA 3MK0A 3WAXA 5DLWA 2ANHA 3OT9A 4ZG9A 3T02A 3SZZA 2XR9A 1ZEBA 1EW8A 3ED4A 3T00A 1E2SP 1KH4A 2W5XA 1EI6A 4LR2A 4CXSA 4KM4A 4KJDA 5L0KA 3BDHA 1ALIA 1O99A 1P49A 5AJ9A 1N2KA 3NKMA 1HJKA 2GSOA 2W5VA 4ZG6A 4NWXA 1KHNA 4ZGAA 1O98A 4FDIA 2G9YA 5LRMA 1ELXA 4TN0A 3KD8A 4KAYA 3WBHA 3NKOA 3M8WA 2D1GA 1B8JA 2W5RA 3NKQA 2GLQA 2IUCA 5LQQA 4UPHA 4UPIA 4CXKA 1E3CP 1E1ZP 1ALHA 4LR7A 3NVLA 2XRGA 1SHQA 4UPKA 2W5WA 2W8DA 4MIVA 5INHA 5LIAA 4GTZA 4UPLA 5GRRA 1KHKA 1HDHA 4CXUA 1ALJA 1EJJA 4GTWA 2W5SA 5C66A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1AUK A;  3WAY A;  5IJS A;  5HRT A;  1KHL A;  4LRF A;  4LRA A;  1N2L A;  1AJB A;  3Q3Q A;  3MK2 A;  3WAV A;  3TG0 A;  4GTY A;  4NWJ A;  3M8Y A;  3CMR A;  3TX0 A;  3BDG A;  5L0E A;  5EGE A;  1ELZ A;  1FSU A;  3UN5 A;  3UN2 A;  3LXQ A;  1KH7 A;  4CYR A;  3M8Z A;  1ELY A;  3UNY A;  4YR1 A;  1ED9 A;  5GOV A;  3UN3 A;  2W5T A;  4UOO A;  2RH6 A;  3E2D A;  4LQY A;  2X98 A;  4KAV A;  5IJQ A;  5KXA A;  3B5Q A;  1SHN A;  1E33 P;  3DPC A;  5TJ3 A;  1KHJ A;  1ZED A;  2IFY A;  3WAW A;  3NKN A;  1ANJ A;  4LRB A;  2QZU A;  4FDJ A;  4GTX A;  2ZKT A;  5EGH A;  3BDF A;  3SZY A;  4CYS A;  1EW9 A;  1ALK A;  2VQR A;  4LRC A;  1K7H A;  2IUC B;  3MK1 A;  2GA3 A;  1EQJ A;  4LR9 A;  1EW2 A;  4LRE A;  3DYC A;  4N7T A;  5DLT A;  4LRD A;  4ZG7 A;  4B56 A;  4UOP A;  1Y7A A;  2W8S A;  3A52 A;  3NKP A;  1AJA A;  1URA A;  2GSU A;  3NKR A;  4QAX A;  1AJC A;  1ED8 A;  1ZEF A;  1AJD A;  1KH5 A;  4MHX A;  3IGZ B;  2GSN A;  3IGY B;  5K4P A;  3UO0 A;  1HQA A;  4UOR A;  3M7V A;  3IDD A;  5L0B A;  3TWZ A;  1URB A;  4LR8 A;  3T01 A;  4KJG A;  5DLV A;  5LRN A;  1Y6V A;  1KH9 A;  1ANI A;  4MY4 A;  3BDG B;  2W5Q A;  3MK0 A;  3WAX A;  5DLW A;  2ANH A;  3OT9 A;  4ZG9 A;  3T02 A;  3SZZ A;  2XR9 A;  1ZEB A;  1EW8 A;  3ED4 A;  3T00 A;  1E2S P;  1KH4 A;  2W5X A;  1EI6 A;  4LR2 A;  4CXS A;  4KM4 A;  4KJD A;  5L0K A;  3BDH A;  1ALI A;  1O99 A;  1P49 A;  5AJ9 A;  1N2K A;  3NKM A;  1HJK A;  2GSO A;  2W5V A;  4ZG6 A;  4NWX A;  1KHN A;  4ZGA A;  1O98 A;  4FDI A;  2G9Y A;  5LRM A;  1ELX A;  4TN0 A;  3KD8 A;  4KAY A;  3WBH A;  3NKO A;  3M8W A;  2D1G A;  1B8J A;  2W5R A;  3NKQ A;  2GLQ A;  2IUC A;  5LQQ A;  4UPH A;  4UPI A;  4CXK A;  1E3C P;  1E1Z P;  1ALH A;  4LR7 A;  3NVL A;  2XRG A;  1SHQ A;  4UPK A;  2W5W A;  2W8D A;  4MIV A;  5INH A;  5LIA A;  4GTZ A;  4UPL A;  5GRR A;  1KHK A;  1HDH A;  4CXU A;  1ALJ A;  1EJJ A;  4GTW A;  2W5S A;  5C66 A; 
#chains in the Genus database with same CATH topology
 1AUK A;  3WAY A;  5IJS A;  5HRT A;  1KHL A;  4LRF A;  4LRA A;  1N2L A;  1AJB A;  3Q3Q A;  3MK2 A;  3WAV A;  3TG0 A;  4GTY A;  4NWJ A;  3M8Y A;  3CMR A;  3TX0 A;  3BDG A;  5L0E A;  5EGE A;  1ELZ A;  1FSU A;  3UN5 A;  3UN2 A;  3LXQ A;  1KH7 A;  4CYR A;  3M8Z A;  1ELY A;  3UNY A;  4YR1 A;  1ED9 A;  5GOV A;  3UN3 A;  2W5T A;  4UOO A;  2RH6 A;  3E2D A;  4LQY A;  2X98 A;  4KAV A;  5IJQ A;  5KXA A;  3B5Q A;  1SHN A;  1E33 P;  3DPC A;  5TJ3 A;  1KHJ A;  1ZED A;  2IFY A;  3WAW A;  3NKN A;  1ANJ A;  4LRB A;  2QZU A;  4FDJ A;  4GTX A;  2ZKT A;  5EGH A;  3BDF A;  3SZY A;  4CYS A;  1EW9 A;  1ALK A;  2VQR A;  4LRC A;  1K7H A;  2IUC B;  3MK1 A;  2GA3 A;  1EQJ A;  4LR9 A;  1EW2 A;  4LRE A;  3DYC A;  4N7T A;  5DLT A;  4LRD A;  4ZG7 A;  4B56 A;  4UOP A;  1Y7A A;  2W8S A;  3A52 A;  3NKP A;  1AJA A;  1URA A;  2GSU A;  3NKR A;  4QAX A;  1AJC A;  1ED8 A;  1ZEF A;  1AJD A;  1KH5 A;  4MHX A;  3IGZ B;  2GSN A;  3IGY B;  5K4P A;  3UO0 A;  1HQA A;  4UOR A;  3M7V A;  3IDD A;  5L0B A;  3TWZ A;  1URB A;  4LR8 A;  3T01 A;  4KJG A;  5DLV A;  5LRN A;  1Y6V A;  1KH9 A;  1ANI A;  4MY4 A;  3BDG B;  2W5Q A;  3MK0 A;  3WAX A;  5DLW A;  2ANH A;  3OT9 A;  4ZG9 A;  3T02 A;  3SZZ A;  2XR9 A;  1ZEB A;  1EW8 A;  3ED4 A;  3T00 A;  1E2S P;  1KH4 A;  2W5X A;  1EI6 A;  4LR2 A;  4CXS A;  4KM4 A;  4KJD A;  5L0K A;  3BDH A;  1ALI A;  1O99 A;  1P49 A;  5AJ9 A;  1N2K A;  3NKM A;  1HJK A;  2GSO A;  2W5V A;  4ZG6 A;  4NWX A;  1KHN A;  4ZGA A;  1O98 A;  4FDI A;  2G9Y A;  5LRM A;  1ELX A;  4TN0 A;  3KD8 A;  4KAY A;  3WBH A;  3NKO A;  3M8W A;  2D1G A;  1B8J A;  2W5R A;  3NKQ A;  2GLQ A;  2IUC A;  5LQQ A;  4UPH A;  4UPI A;  4CXK A;  1E3C P;  1E1Z P;  1ALH A;  4LR7 A;  3NVL A;  2XRG A;  1SHQ A;  4UPK A;  2W5W A;  2W8D A;  4MIV A;  5INH A;  5LIA A;  4GTZ A;  4UPL A;  5GRR A;  1KHK A;  1HDH A;  4CXU A;  1ALJ A;  1EJJ A;  4GTW A;  2W5S A;  5C66 A; 
#chains in the Genus database with same CATH homology
 1AUK A;  3WAY A;  5IJS A;  5HRT A;  1KHL A;  4LRF A;  4LRA A;  1N2L A;  1AJB A;  3Q3Q A;  3MK2 A;  3WAV A;  3TG0 A;  4GTY A;  4NWJ A;  3M8Y A;  3CMR A;  3TX0 A;  3BDG A;  5L0E A;  5EGE A;  1ELZ A;  1FSU A;  3UN5 A;  3UN2 A;  3LXQ A;  1KH7 A;  4CYR A;  3M8Z A;  1ELY A;  3UNY A;  4YR1 A;  1ED9 A;  5GOV A;  3UN3 A;  2W5T A;  4UOO A;  2RH6 A;  3E2D A;  4LQY A;  2X98 A;  4KAV A;  5IJQ A;  5KXA A;  3B5Q A;  1SHN A;  1E33 P;  3DPC A;  5TJ3 A;  1KHJ A;  1ZED A;  2IFY A;  3WAW A;  3NKN A;  1ANJ A;  4LRB A;  2QZU A;  4FDJ A;  4GTX A;  2ZKT A;  5EGH A;  3BDF A;  3SZY A;  4CYS A;  1EW9 A;  1ALK A;  2VQR A;  4LRC A;  1K7H A;  2IUC B;  3MK1 A;  2GA3 A;  1EQJ A;  4LR9 A;  1EW2 A;  4LRE A;  3DYC A;  4N7T A;  5DLT A;  4LRD A;  4ZG7 A;  4B56 A;  4UOP A;  1Y7A A;  2W8S A;  3A52 A;  3NKP A;  1AJA A;  1URA A;  2GSU A;  3NKR A;  4QAX A;  1AJC A;  1ED8 A;  1ZEF A;  1AJD A;  1KH5 A;  4MHX A;  3IGZ B;  2GSN A;  3IGY B;  5K4P A;  3UO0 A;  1HQA A;  4UOR A;  3M7V A;  3IDD A;  5L0B A;  3TWZ A;  1URB A;  4LR8 A;  3T01 A;  4KJG A;  5DLV A;  5LRN A;  1Y6V A;  1KH9 A;  1ANI A;  4MY4 A;  3BDG B;  2W5Q A;  3MK0 A;  3WAX A;  5DLW A;  2ANH A;  3OT9 A;  4ZG9 A;  3T02 A;  3SZZ A;  2XR9 A;  1ZEB A;  1EW8 A;  3ED4 A;  3T00 A;  1E2S P;  1KH4 A;  2W5X A;  1EI6 A;  4LR2 A;  4CXS A;  4KM4 A;  4KJD A;  5L0K A;  3BDH A;  1ALI A;  1O99 A;  1P49 A;  5AJ9 A;  1N2K A;  3NKM A;  1HJK A;  2GSO A;  2W5V A;  4ZG6 A;  4NWX A;  1KHN A;  4ZGA A;  1O98 A;  4FDI A;  2G9Y A;  5LRM A;  1ELX A;  4TN0 A;  3KD8 A;  4KAY A;  3WBH A;  3NKO A;  3M8W A;  2D1G A;  1B8J A;  2W5R A;  3NKQ A;  2GLQ A;  2IUC A;  5LQQ A;  4UPH A;  4UPI A;  4CXK A;  1E3C P;  1E1Z P;  1ALH A;  4LR7 A;  3NVL A;  2XRG A;  1SHQ A;  4UPK A;  2W5W A;  2W8D A;  4MIV A;  5INH A;  5LIA A;  4GTZ A;  4UPL A;  5GRR A;  1KHK A;  1HDH A;  4CXU A;  1ALJ A;  1EJJ A;  4GTW A;  2W5S A;  5C66 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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