1OSIA

Structure of 3-isopropylmalate dehydrogenase
Total Genus 113
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
113
sequence length
345
structure length
345
Chain Sequence
MKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFEAARKRRKHVVSVDKANVLEVGEFWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELARKVEDAVAKALLETPPPDLGGSAGTEAFTATVLRHLA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase
molecule keywords 3-ISOPROPYLMALATE DEHYDROGENASE
publication title A mutation at the interface between domains causes rearrangement of domains in 3-isopropylmalate dehydrogenase.
pubmed doi rcsb
source organism Thermus thermophilus
total genus 113
structure length 345
sequence length 345
chains with identical sequence B, C, D
ec nomenclature ec 1.1.1.85: 3-isopropylmalate dehydrogenase.
pdb deposition date 1996-10-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 1osiA00
1ZORA 1XABA 2Y42A 3VL6A 4AJCA 4I3KA 1V53A 4AJSA 4XS3A 1T09A 1PB1A 3VL4A 7ICDA 1YCOA 1WALA 1ISOA 1WPWA 5GRLA 1HEXA 3LXYA 3VL3A 4HCXA 3FLKA 2QFXA 4AOUA 3U1HA 5GRHA 3US8A 5GRHB 1GC9A 1P8FA 3BLVB 5K11A 2Y40A 1PB3A 5J32A 4AJRA 3WZYA 5L58A 4IWHA 1V5BA 5GREA 5GRFB 2AYQA 1VI1A 2HI1A 1SJSA 1PS7A 1HQSA 3UDUA 1IDEA 4UMXA 1U7NA 1V94A 1HJ6A 3WZVA 2Y3ZA 1T0LA 5I95A 8ICDA 1XKDA 1XAAA 1G2UA 4I3LA 4BNPA 5J33A 3TY4A 1OSJA 3WZXA 1DR8A 4XRXA 3TY3A 1CW4A 3TSNA 5LGEA 3VMKA 1IDCA 1DR0A 3TNGA 3VKZA 2ZTWA 2QFYA 2D4VA 2D1CA 5HN4A 9ICDA 3DMSA 4L03A 1GC8A 5HN5A 1IDMA 4ICDA 5GRFA 1CW7A 3UF6A 3BLXB 1VLCA 3FMXX 4L06A 5I96A 2IV0A 3VMLA 3VMJA 4L04A 3VL2A 1GROA 3ASJA 5K10A 1LWDA 1IKAA 1XADA 2G4OA 1XGVA 3ICDA 4UMYA 5GRIB 3VL7A 4AJBA 1TYOA 4AOVA 3MARA 2E5MA 2UXQA 5HN6A 1AI3A 3MAPA 4ATYA 1GRPA 1YXOA 4P69C 1PS6A 3MASB 1IDFA 1R8KA 3WZWA 3INMA 1CM7A 4WUOA 3BLXA 3U9EA 4AJAA 4KZOA 3R8WA 2QFVA 4XXVA 1XACA 5J34A 5ICDA 4F7IA 4AJ3A 2UXRA 1W0DA 3UDOA 3LCBC 5GRLB 1PTMA 1OSIA 3AH3A 1IDDA 6ICDA 4AOYA 5GRIA 1CW1A 2Y41A 1DPZA 1AI2A 4JQPA 1BL5A 2QFWA 4YB4A 5L57A 1A05A 2DHTA 4Y1PA 1IPDA 5GREB 5DE1A 3BLVA 3MASA 4JA8A 1X0LA 5HN3A 1CNZA 2E0CA
chains in the Genus database with same CATH superfamily
1ZORA 1XABA 2Y42A 3VL6A 4AJCA 4I3KA 1V53A 4AJSA 4XS3A 1T09A 1PB1A 3VL4A 7ICDA 1YCOA 1WALA 1ISOA 1WPWA 5GRLA 1HEXA 3LXYA 3VL3A 4HCXA 3FLKA 2QFXA 4AOUA 3U1HA 5GRHA 3US8A 5GRHB 1GC9A 1P8FA 3BLVB 5K11A 2Y40A 1PB3A 5J32A 4AJRA 3WZYA 5L58A 4IWHA 1V5BA 5GREA 5GRFB 2AYQA 1VI1A 2HI1A 1SJSA 1PS7A 1HQSA 3UDUA 1IDEA 4UMXA 1U7NA 1V94A 1HJ6A 3WZVA 2Y3ZA 1T0LA 5I95A 8ICDA 1XKDA 1XAAA 1G2UA 4I3LA 4BNPA 5J33A 3TY4A 1OSJA 3WZXA 1DR8A 4XRXA 3TY3A 1CW4A 3TSNA 5LGEA 3VMKA 1IDCA 1DR0A 3TNGA 3VKZA 2ZTWA 2QFYA 2D4VA 2D1CA 5HN4A 9ICDA 3DMSA 4L03A 1GC8A 5HN5A 1IDMA 4ICDA 5GRFA 1CW7A 3UF6A 3BLXB 1VLCA 3FMXX 4L06A 5I96A 2IV0A 3VMLA 3VMJA 4L04A 3VL2A 1GROA 3ASJA 5K10A 1LWDA 1IKAA 1XADA 2G4OA 1XGVA 3ICDA 4UMYA 5GRIB 3VL7A 4AJBA 1TYOA 4AOVA 3MARA 2E5MA 2UXQA 5HN6A 1AI3A 3MAPA 4ATYA 1GRPA 1YXOA 4P69C 1PS6A 3MASB 1IDFA 1R8KA 3WZWA 3INMA 1CM7A 4WUOA 3BLXA 3U9EA 4AJAA 4KZOA 3R8WA 2QFVA 4XXVA 1XACA 5J34A 5ICDA 4F7IA 4AJ3A 2UXRA 1W0DA 3UDOA 3LCBC 5GRLB 1PTMA 1OSIA 3AH3A 1IDDA 6ICDA 4AOYA 5GRIA 1CW1A 2Y41A 1DPZA 1AI2A 4JQPA 1BL5A 2QFWA 4YB4A 5L57A 1A05A 2DHTA 4Y1PA 1IPDA 5GREB 5DE1A 3BLVA 3MASA 4JA8A 1X0LA 5HN3A 1CNZA 2E0CA
chains in the Genus database with same CATH topology
1ZORA 1XABA 2Y42A 3VL6A 4AJCA 4I3KA 1V53A 4AJSA 4XS3A 1T09A 1PB1A 3VL4A 7ICDA 1YCOA 1WALA 1ISOA 1WPWA 5GRLA 1HEXA 3LXYA 3VL3A 4HCXA 3FLKA 2QFXA 4AOUA 3U1HA 5GRHA 3US8A 5GRHB 1GC9A 1P8FA 3BLVB 5K11A 2Y40A 1PB3A 5J32A 4AJRA 3WZYA 5L58A 4IWHA 1V5BA 5GREA 5GRFB 2AYQA 1VI1A 2HI1A 1SJSA 1PS7A 1HQSA 3UDUA 1IDEA 4UMXA 1U7NA 1V94A 1HJ6A 3WZVA 2Y3ZA 1T0LA 5I95A 8ICDA 1XKDA 1XAAA 1G2UA 4I3LA 4BNPA 5J33A 3TY4A 1OSJA 3WZXA 1DR8A 4XRXA 3TY3A 1CW4A 3TSNA 5LGEA 3VMKA 1IDCA 1DR0A 3TNGA 3VKZA 2ZTWA 2QFYA 2D4VA 2D1CA 5HN4A 9ICDA 3DMSA 4L03A 1GC8A 5HN5A 1IDMA 4ICDA 5GRFA 1CW7A 3UF6A 3BLXB 1VLCA 3FMXX 4L06A 5I96A 2IV0A 3VMLA 3VMJA 4L04A 3VL2A 1GROA 3ASJA 5K10A 1LWDA 1IKAA 1XADA 2G4OA 1XGVA 3ICDA 4UMYA 5GRIB 3VL7A 4AJBA 1TYOA 4AOVA 3MARA 2E5MA 2UXQA 5HN6A 1AI3A 3MAPA 4ATYA 1GRPA 1YXOA 4P69C 1PS6A 3MASB 1IDFA 1R8KA 3WZWA 3INMA 1CM7A 4WUOA 3BLXA 3U9EA 4AJAA 4KZOA 3R8WA 2QFVA 4XXVA 1XACA 5J34A 5ICDA 4F7IA 4AJ3A 2UXRA 1W0DA 3UDOA 3LCBC 5GRLB 1PTMA 1OSIA 3AH3A 1IDDA 6ICDA 4AOYA 5GRIA 1CW1A 2Y41A 1DPZA 1AI2A 4JQPA 1BL5A 2QFWA 4YB4A 5L57A 1A05A 2DHTA 4Y1PA 1IPDA 5GREB 5DE1A 3BLVA 3MASA 4JA8A 1X0LA 5HN3A 1CNZA 2E0CA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZOR A;  1XAB A;  2Y42 A;  3VL6 A;  4AJC A;  4I3K A;  1V53 A;  4AJS A;  4XS3 A;  1T09 A;  1PB1 A;  3VL4 A;  7ICD A;  1YCO A;  1WAL A;  1ISO A;  1WPW A;  5GRL A;  1HEX A;  3LXY A;  3VL3 A;  4HCX A;  3FLK A;  2QFX A;  4AOU A;  3U1H A;  5GRH A;  3US8 A;  5GRH B;  1GC9 A;  1P8F A;  3BLV B;  5K11 A;  2Y40 A;  1PB3 A;  5J32 A;  4AJR A;  3WZY A;  5L58 A;  4IWH A;  1V5B A;  5GRE A;  5GRF B;  2AYQ A;  1VI1 A;  2HI1 A;  1SJS A;  1PS7 A;  1HQS A;  3UDU A;  1IDE A;  4UMX A;  1U7N A;  1V94 A;  1HJ6 A;  3WZV A;  2Y3Z A;  1T0L A;  5I95 A;  8ICD A;  1XKD A;  1XAA A;  1G2U A;  4I3L A;  4BNP A;  5J33 A;  3TY4 A;  1OSJ A;  3WZX A;  1DR8 A;  4XRX A;  3TY3 A;  1CW4 A;  3TSN A;  5LGE A;  3VMK A;  1IDC A;  1DR0 A;  3TNG A;  3VKZ A;  2ZTW A;  2QFY A;  2D4V A;  2D1C A;  5HN4 A;  9ICD A;  3DMS A;  4L03 A;  1GC8 A;  5HN5 A;  1IDM A;  4ICD A;  5GRF A;  1CW7 A;  3UF6 A;  3BLX B;  1VLC A;  3FMX X;  4L06 A;  5I96 A;  2IV0 A;  3VML A;  3VMJ A;  4L04 A;  3VL2 A;  1GRO A;  3ASJ A;  5K10 A;  1LWD A;  1IKA A;  1XAD A;  2G4O A;  1XGV A;  3ICD A;  4UMY A;  5GRI B;  3VL7 A;  4AJB A;  1TYO A;  4AOV A;  3MAR A;  2E5M A;  2UXQ A;  5HN6 A;  1AI3 A;  3MAP A;  4ATY A;  1GRP A;  1YXO A;  4P69 C;  1PS6 A;  3MAS B;  1IDF A;  1R8K A;  3WZW A;  3INM A;  1CM7 A;  4WUO A;  3BLX A;  3U9E A;  4AJA A;  4KZO A;  3R8W A;  2QFV A;  4XXV A;  1XAC A;  5J34 A;  5ICD A;  4F7I A;  4AJ3 A;  2UXR A;  1W0D A;  3UDO A;  3LCB C;  5GRL B;  1PTM A;  1OSI A;  3AH3 A;  1IDD A;  6ICD A;  4AOY A;  5GRI A;  1CW1 A;  2Y41 A;  1DPZ A;  1AI2 A;  4JQP A;  1BL5 A;  2QFW A;  4YB4 A;  5L57 A;  1A05 A;  2DHT A;  4Y1P A;  1IPD A;  5GRE B;  5DE1 A;  3BLV A;  3MAS A;  4JA8 A;  1X0L A;  5HN3 A;  1CNZ A;  2E0C A; 
#chains in the Genus database with same CATH topology
 1ZOR A;  1XAB A;  2Y42 A;  3VL6 A;  4AJC A;  4I3K A;  1V53 A;  4AJS A;  4XS3 A;  1T09 A;  1PB1 A;  3VL4 A;  7ICD A;  1YCO A;  1WAL A;  1ISO A;  1WPW A;  5GRL A;  1HEX A;  3LXY A;  3VL3 A;  4HCX A;  3FLK A;  2QFX A;  4AOU A;  3U1H A;  5GRH A;  3US8 A;  5GRH B;  1GC9 A;  1P8F A;  3BLV B;  5K11 A;  2Y40 A;  1PB3 A;  5J32 A;  4AJR A;  3WZY A;  5L58 A;  4IWH A;  1V5B A;  5GRE A;  5GRF B;  2AYQ A;  1VI1 A;  2HI1 A;  1SJS A;  1PS7 A;  1HQS A;  3UDU A;  1IDE A;  4UMX A;  1U7N A;  1V94 A;  1HJ6 A;  3WZV A;  2Y3Z A;  1T0L A;  5I95 A;  8ICD A;  1XKD A;  1XAA A;  1G2U A;  4I3L A;  4BNP A;  5J33 A;  3TY4 A;  1OSJ A;  3WZX A;  1DR8 A;  4XRX A;  3TY3 A;  1CW4 A;  3TSN A;  5LGE A;  3VMK A;  1IDC A;  1DR0 A;  3TNG A;  3VKZ A;  2ZTW A;  2QFY A;  2D4V A;  2D1C A;  5HN4 A;  9ICD A;  3DMS A;  4L03 A;  1GC8 A;  5HN5 A;  1IDM A;  4ICD A;  5GRF A;  1CW7 A;  3UF6 A;  3BLX B;  1VLC A;  3FMX X;  4L06 A;  5I96 A;  2IV0 A;  3VML A;  3VMJ A;  4L04 A;  3VL2 A;  1GRO A;  3ASJ A;  5K10 A;  1LWD A;  1IKA A;  1XAD A;  2G4O A;  1XGV A;  3ICD A;  4UMY A;  5GRI B;  3VL7 A;  4AJB A;  1TYO A;  4AOV A;  3MAR A;  2E5M A;  2UXQ A;  5HN6 A;  1AI3 A;  3MAP A;  4ATY A;  1GRP A;  1YXO A;  4P69 C;  1PS6 A;  3MAS B;  1IDF A;  1R8K A;  3WZW A;  3INM A;  1CM7 A;  4WUO A;  3BLX A;  3U9E A;  4AJA A;  4KZO A;  3R8W A;  2QFV A;  4XXV A;  1XAC A;  5J34 A;  5ICD A;  4F7I A;  4AJ3 A;  2UXR A;  1W0D A;  3UDO A;  3LCB C;  5GRL B;  1PTM A;  1OSI A;  3AH3 A;  1IDD A;  6ICD A;  4AOY A;  5GRI A;  1CW1 A;  2Y41 A;  1DPZ A;  1AI2 A;  4JQP A;  1BL5 A;  2QFW A;  4YB4 A;  5L57 A;  1A05 A;  2DHT A;  4Y1P A;  1IPD A;  5GRE B;  5DE1 A;  3BLV A;  3MAS A;  4JA8 A;  1X0L A;  5HN3 A;  1CNZ A;  2E0C A; 
#chains in the Genus database with same CATH homology
 1ZOR A;  1XAB A;  2Y42 A;  3VL6 A;  4AJC A;  4I3K A;  1V53 A;  4AJS A;  4XS3 A;  1T09 A;  1PB1 A;  3VL4 A;  7ICD A;  1YCO A;  1WAL A;  1ISO A;  1WPW A;  5GRL A;  1HEX A;  3LXY A;  3VL3 A;  4HCX A;  3FLK A;  2QFX A;  4AOU A;  3U1H A;  5GRH A;  3US8 A;  5GRH B;  1GC9 A;  1P8F A;  3BLV B;  5K11 A;  2Y40 A;  1PB3 A;  5J32 A;  4AJR A;  3WZY A;  5L58 A;  4IWH A;  1V5B A;  5GRE A;  5GRF B;  2AYQ A;  1VI1 A;  2HI1 A;  1SJS A;  1PS7 A;  1HQS A;  3UDU A;  1IDE A;  4UMX A;  1U7N A;  1V94 A;  1HJ6 A;  3WZV A;  2Y3Z A;  1T0L A;  5I95 A;  8ICD A;  1XKD A;  1XAA A;  1G2U A;  4I3L A;  4BNP A;  5J33 A;  3TY4 A;  1OSJ A;  3WZX A;  1DR8 A;  4XRX A;  3TY3 A;  1CW4 A;  3TSN A;  5LGE A;  3VMK A;  1IDC A;  1DR0 A;  3TNG A;  3VKZ A;  2ZTW A;  2QFY A;  2D4V A;  2D1C A;  5HN4 A;  9ICD A;  3DMS A;  4L03 A;  1GC8 A;  5HN5 A;  1IDM A;  4ICD A;  5GRF A;  1CW7 A;  3UF6 A;  3BLX B;  1VLC A;  3FMX X;  4L06 A;  5I96 A;  2IV0 A;  3VML A;  3VMJ A;  4L04 A;  3VL2 A;  1GRO A;  3ASJ A;  5K10 A;  1LWD A;  1IKA A;  1XAD A;  2G4O A;  1XGV A;  3ICD A;  4UMY A;  5GRI B;  3VL7 A;  4AJB A;  1TYO A;  4AOV A;  3MAR A;  2E5M A;  2UXQ A;  5HN6 A;  1AI3 A;  3MAP A;  4ATY A;  1GRP A;  1YXO A;  4P69 C;  1PS6 A;  3MAS B;  1IDF A;  1R8K A;  3WZW A;  3INM A;  1CM7 A;  4WUO A;  3BLX A;  3U9E A;  4AJA A;  4KZO A;  3R8W A;  2QFV A;  4XXV A;  1XAC A;  5J34 A;  5ICD A;  4F7I A;  4AJ3 A;  2UXR A;  1W0D A;  3UDO A;  3LCB C;  5GRL B;  1PTM A;  1OSI A;  3AH3 A;  1IDD A;  6ICD A;  4AOY A;  5GRI A;  1CW1 A;  2Y41 A;  1DPZ A;  1AI2 A;  4JQP A;  1BL5 A;  2QFW A;  4YB4 A;  5L57 A;  1A05 A;  2DHT A;  4Y1P A;  1IPD A;  5GRE B;  5DE1 A;  3BLV A;  3MAS A;  4JA8 A;  1X0L A;  5HN3 A;  1CNZ A;  2E0C A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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