1OYHL

Crystal structure of p13 alanine variant of antithrombin
Total Genus 121
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
121
sequence length
426
structure length
410
Chain Sequence
VDICTAKPRDIPMNPMCIYRSPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPRVTFKANRPFLVFIREVPLNTIIFMGRVANPC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The influence of hinge region residue Glu-381 on antithrombin allostery and metastability
pubmed doi rcsb
molecule keywords Antithrombin-III
molecule tags Blood clotting
source organism Homo sapiens
total genus 121
structure length 410
sequence length 426
ec nomenclature
pdb deposition date 2003-04-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 1oyhL01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 1oyhL02
1OVAB 3B9FI 1JVQI 1DZGI 1YXAA 2ARQA 1T1FA 2HIJL 2B4XL 2VH4A 3NDDA 4AU3B 4CAAA 2VDXA 2WXWA 3CVMA 3EVJI 3H5CA 2XN6A 1R1LI 2PEEA 1BY7A 1DZGL 4AU2A 1XQGA 4AU4A 8APIA 4YIAA 2D26A 1B3KA 4DY0A 4C41A 1JJOC 1QLPA 2B5TI 1WZ9A 4Y3KA 1LQ8A 2ACHA 1K9OI 3STOA 1BR8I 4AFXA 2H4RA 2OL2A 3NDAA 4ZK0A 9PAIA 3NE4A 2ZNHA 4AJTA 1LJ5A 4KDSA 5BRRI 1JMOA 2R9YA 3NDFA 2HI9A 3R4LA 4C49A 3EOXA 1HLEA 3PZFA 4RO9A 4ZK3A 1MTPA 3LE2A 3VVJA 2BEHL 3FGQA 3UT3A 1IZ2A 2WXZC 4P0OA 3CWMA 1OPHA 1OVAC 1QMBA 2WXXA 1OVAA 1PSIA 1QMNA 5CDZA 3DRUA 2ZV6A 4AQHA 1NQ9I 1JRRA 1AZXI 1SEKA 4R9IA 1C5GA 5C98A 2VDYA 1IMVA 2XN7A 2RIVA 1OO8A 4DTEA 2BEHI 1HP7A 1ATUA 1OYHI 1KCTA 1SR5A 1M93B 1XU8A 2GD4C 2PEFA 2QUGA 4IC0A 3F02A 2WY1A 5INWA 4EB1I 1D5SA 2XN3A 3CWLA 1AS4A 1ANTI 1OYHL 5EI0A 3ZHAA 2OAYA 2WXZA 3LW2A 1TB6I 1E04I 4EB1L 1E05I 1SNGA 9APIA 1JMJA 2H4PA 4AJUA 4G8RA 1DZHL 4AU3A 3Q02A 4DY7C 3CAAA 1OC0A 3F1SA 1A7CA 4ROBA 4BB2A 3PB1I 4G8OA 2ANTI 2XN5A 5IO1A 1EZXA 3KCGI 4Y40A 2WXYC 2ARRA 3DRMA 1ATHA 3F5NA 2V95A 2H4QA 4IF8A 2WY0C 4X30A 1DZHI 2CEOA 4GA7A 1F0CA 2DUTA 5HGCA 1E03I 4P0FA 4PYWA 1DVNA 5CDXA 1ATTA 3T1PA 3DY0A 1DB2A 4RSQA 1C8OA 2HIJI 1DVMA 2B4XI 3OZQA 1JTIA 7APIA 3DLWA 3Q03A 1LK6I 5CE0A 4ROAA 2RIWA 1XQJA 1UHGA
chains in the Genus database with same CATH superfamily
1OVAB 3B9FI 1JVQI 1DZGI 1YXAA 2ARQA 1T1FA 2HIJL 2B4XL 2VH4A 3NDDA 4AU3B 4CAAA 2VDXA 2WXWA 3CVMA 3EVJI 3H5CA 2XN6A 1R1LI 2PEEA 1BY7A 1DZGL 4AU2A 1XQGA 4AU4A 8APIA 4YIAA 2D26A 1B3KA 4DY0A 4C41A 1JJOC 1QLPA 2B5TI 1WZ9A 4Y3KA 1LQ8A 2ACHA 1K9OI 3STOA 1BR8I 4AFXA 2H4RA 2OL2A 3NDAA 4ZK0A 9PAIA 3NE4A 2ZNHA 4AJTA 1LJ5A 4KDSA 5BRRI 1JMOA 2R9YA 3NDFA 2HI9A 3R4LA 4C49A 3EOXA 1HLEA 3PZFA 4RO9A 4ZK3A 1MTPA 3LE2A 3VVJA 2BEHL 3FGQA 3UT3A 1IZ2A 2WXZC 4P0OA 3CWMA 1OPHA 1OVAC 1QMBA 2WXXA 1OVAA 1PSIA 1QMNA 5CDZA 3DRUA 2ZV6A 4AQHA 1NQ9I 1JRRA 1AZXI 1SEKA 4R9IA 1C5GA 5C98A 2VDYA 1IMVA 2XN7A 2RIVA 1OO8A 4DTEA 2BEHI 1HP7A 1ATUA 1OYHI 1KCTA 1SR5A 1M93B 1XU8A 2GD4C 2PEFA 2QUGA 4IC0A 3F02A 2WY1A 5INWA 4EB1I 1D5SA 2XN3A 3CWLA 1AS4A 1ANTI 1OYHL 5EI0A 3ZHAA 2OAYA 2WXZA 3LW2A 1TB6I 1E04I 4EB1L 1E05I 1SNGA 9APIA 1JMJA 2H4PA 4AJUA 4G8RA 1DZHL 4AU3A 3Q02A 4DY7C 3CAAA 1OC0A 3F1SA 1A7CA 4ROBA 4BB2A 3PB1I 4G8OA 2ANTI 2XN5A 5IO1A 1EZXA 3KCGI 4Y40A 2WXYC 2ARRA 3DRMA 1ATHA 3F5NA 2V95A 2H4QA 4IF8A 2WY0C 4X30A 1DZHI 2CEOA 4GA7A 1F0CA 2DUTA 5HGCA 1E03I 4P0FA 4PYWA 1DVNA 5CDXA 1ATTA 3T1PA 3DY0A 1DB2A 4RSQA 1C8OA 2HIJI 1DVMA 2B4XI 3OZQA 1JTIA 7APIA 3DLWA 3Q03A 1LK6I 5CE0A 4ROAA 2RIWA 1XQJA 1UHGA
chains in the Genus database with same CATH topology
1OVAB 3B9FI 1JVQI 1DZGI 1YXAA 2ARQA 1T1FA 2HIJL 2B4XL 2VH4A 3NDDA 4AU3B 4CAAA 2VDXA 2WXWA 3CVMA 3EVJI 3H5CA 2XN6A 1R1LI 2PEEA 1BY7A 1DZGL 4AU2A 1XQGA 4AU4A 8APIA 4YIAA 2D26A 1B3KA 4DY0A 4C41A 1JJOC 1QLPA 2B5TI 1WZ9A 4Y3KA 1LQ8A 2ACHA 1K9OI 3STOA 1BR8I 4AFXA 2H4RA 2OL2A 3NDAA 4ZK0A 9PAIA 3NE4A 2ZNHA 4AJTA 1LJ5A 4KDSA 5BRRI 1JMOA 2R9YA 3NDFA 2HI9A 3R4LA 4C49A 3EOXA 1HLEA 3PZFA 4RO9A 4ZK3A 1MTPA 3LE2A 3VVJA 2BEHL 3FGQA 3UT3A 1IZ2A 2WXZC 4P0OA 3CWMA 1OPHA 1OVAC 1QMBA 2WXXA 1OVAA 1PSIA 1QMNA 5CDZA 3DRUA 2ZV6A 4AQHA 1NQ9I 1JRRA 1AZXI 1SEKA 4R9IA 1C5GA 5C98A 2VDYA 1IMVA 2XN7A 2RIVA 1OO8A 4DTEA 2BEHI 1HP7A 1ATUA 1OYHI 1KCTA 1SR5A 1M93B 1XU8A 2GD4C 2PEFA 2QUGA 4IC0A 3F02A 2WY1A 5INWA 4EB1I 1D5SA 2XN3A 3CWLA 1AS4A 1ANTI 1OYHL 5EI0A 3ZHAA 2OAYA 2WXZA 3LW2A 1TB6I 1E04I 4EB1L 1E05I 1SNGA 9APIA 1JMJA 2H4PA 4AJUA 4G8RA 1DZHL 4AU3A 3Q02A 4DY7C 3CAAA 1OC0A 3F1SA 1A7CA 4ROBA 4BB2A 3PB1I 4G8OA 2ANTI 2XN5A 5IO1A 1EZXA 3KCGI 4Y40A 2WXYC 2ARRA 3DRMA 1ATHA 3F5NA 2V95A 2H4QA 4IF8A 2WY0C 4X30A 1DZHI 2CEOA 4GA7A 1F0CA 2DUTA 5HGCA 1E03I 4P0FA 4PYWA 1DVNA 5CDXA 1ATTA 3T1PA 3DY0A 1DB2A 4RSQA 1C8OA 2HIJI 1DVMA 2B4XI 3OZQA 1JTIA 7APIA 3DLWA 3Q03A 1LK6I 5CE0A 4ROAA 2RIWA 1XQJA 1UHGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1OVA B;  3B9F I;  1JVQ I;  1DZG I;  1YXA A;  2ARQ A;  1T1F A;  2HIJ L;  2B4X L;  2VH4 A;  3NDD A;  4AU3 B;  4CAA A;  2VDX A;  2WXW A;  3CVM A;  3EVJ I;  3H5C A;  2XN6 A;  1R1L I;  2PEE A;  1BY7 A;  1DZG L;  4AU2 A;  1XQG A;  4AU4 A;  8API A;  4YIA A;  2D26 A;  1B3K A;  4DY0 A;  4C41 A;  1JJO C;  1QLP A;  2B5T I;  1WZ9 A;  4Y3K A;  1LQ8 A;  2ACH A;  1K9O I;  3STO A;  1BR8 I;  4AFX A;  2H4R A;  2OL2 A;  3NDA A;  4ZK0 A;  9PAI A;  3NE4 A;  2ZNH A;  4AJT A;  1LJ5 A;  4KDS A;  5BRR I;  1JMO A;  2R9Y A;  3NDF A;  2HI9 A;  3R4L A;  4C49 A;  3EOX A;  1HLE A;  3PZF A;  4RO9 A;  4ZK3 A;  1MTP A;  3LE2 A;  3VVJ A;  2BEH L;  3FGQ A;  3UT3 A;  1IZ2 A;  2WXZ C;  4P0O A;  3CWM A;  1OPH A;  1OVA C;  1QMB A;  2WXX A;  1OVA A;  1PSI A;  1QMN A;  5CDZ A;  3DRU A;  2ZV6 A;  4AQH A;  1NQ9 I;  1JRR A;  1AZX I;  1SEK A;  4R9I A;  1C5G A;  5C98 A;  2VDY A;  1IMV A;  2XN7 A;  2RIV A;  1OO8 A;  4DTE A;  2BEH I;  1HP7 A;  1ATU A;  1OYH I;  1KCT A;  1SR5 A;  1M93 B;  1XU8 A;  2GD4 C;  2PEF A;  2QUG A;  4IC0 A;  3F02 A;  2WY1 A;  5INW A;  4EB1 I;  1D5S A;  2XN3 A;  3CWL A;  1AS4 A;  1ANT I;  1OYH L;  5EI0 A;  3ZHA A;  2OAY A;  2WXZ A;  3LW2 A;  1TB6 I;  1E04 I;  4EB1 L;  1E05 I;  1SNG A;  9API A;  1JMJ A;  2H4P A;  4AJU A;  4G8R A;  1DZH L;  4AU3 A;  3Q02 A;  4DY7 C;  3CAA A;  1OC0 A;  3F1S A;  1A7C A;  4ROB A;  4BB2 A;  3PB1 I;  4G8O A;  2ANT I;  2XN5 A;  5IO1 A;  1EZX A;  3KCG I;  4Y40 A;  2WXY C;  2ARR A;  3DRM A;  1ATH A;  3F5N A;  2V95 A;  2H4Q A;  4IF8 A;  2WY0 C;  4X30 A;  1DZH I;  2CEO A;  4GA7 A;  1F0C A;  2DUT A;  5HGC A;  1E03 I;  4P0F A;  4PYW A;  1DVN A;  5CDX A;  1ATT A;  3T1P A;  3DY0 A;  1DB2 A;  4RSQ A;  1C8O A;  2HIJ I;  1DVM A;  2B4X I;  3OZQ A;  1JTI A;  7API A;  3DLW A;  3Q03 A;  1LK6 I;  5CE0 A;  4ROA A;  2RIW A;  1XQJ A;  1UHG A; 
#chains in the Genus database with same CATH topology
 1OVA B;  3B9F I;  1JVQ I;  1DZG I;  1YXA A;  2ARQ A;  1T1F A;  2HIJ L;  2B4X L;  2VH4 A;  3NDD A;  4AU3 B;  4CAA A;  2VDX A;  2WXW A;  3CVM A;  3EVJ I;  3H5C A;  2XN6 A;  1R1L I;  2PEE A;  1BY7 A;  1DZG L;  4AU2 A;  1XQG A;  4AU4 A;  8API A;  4YIA A;  2D26 A;  1B3K A;  4DY0 A;  4C41 A;  1JJO C;  1QLP A;  2B5T I;  1WZ9 A;  4Y3K A;  1LQ8 A;  2ACH A;  1K9O I;  3STO A;  1BR8 I;  4AFX A;  2H4R A;  2OL2 A;  3NDA A;  4ZK0 A;  9PAI A;  3NE4 A;  2ZNH A;  4AJT A;  1LJ5 A;  4KDS A;  5BRR I;  1JMO A;  2R9Y A;  3NDF A;  2HI9 A;  3R4L A;  4C49 A;  3EOX A;  1HLE A;  3PZF A;  4RO9 A;  4ZK3 A;  1MTP A;  3LE2 A;  3VVJ A;  2BEH L;  3FGQ A;  3UT3 A;  1IZ2 A;  2WXZ C;  4P0O A;  3CWM A;  1OPH A;  1OVA C;  1QMB A;  2WXX A;  1OVA A;  1PSI A;  1QMN A;  5CDZ A;  3DRU A;  2ZV6 A;  4AQH A;  1NQ9 I;  1JRR A;  1AZX I;  1SEK A;  4R9I A;  1C5G A;  5C98 A;  2VDY A;  1IMV A;  2XN7 A;  2RIV A;  1OO8 A;  4DTE A;  2BEH I;  1HP7 A;  1ATU A;  1OYH I;  1KCT A;  1SR5 A;  1M93 B;  1XU8 A;  2GD4 C;  2PEF A;  2QUG A;  4IC0 A;  3F02 A;  2WY1 A;  5INW A;  4EB1 I;  1D5S A;  2XN3 A;  3CWL A;  1AS4 A;  1ANT I;  1OYH L;  5EI0 A;  3ZHA A;  2OAY A;  2WXZ A;  3LW2 A;  1TB6 I;  1E04 I;  4EB1 L;  1E05 I;  1SNG A;  9API A;  1JMJ A;  2H4P A;  4AJU A;  4G8R A;  1DZH L;  4AU3 A;  3Q02 A;  4DY7 C;  3CAA A;  1OC0 A;  3F1S A;  1A7C A;  4ROB A;  4BB2 A;  3PB1 I;  4G8O A;  2ANT I;  2XN5 A;  5IO1 A;  1EZX A;  3KCG I;  4Y40 A;  2WXY C;  2ARR A;  3DRM A;  1ATH A;  3F5N A;  2V95 A;  2H4Q A;  4IF8 A;  2WY0 C;  4X30 A;  1DZH I;  2CEO A;  4GA7 A;  1F0C A;  2DUT A;  5HGC A;  1E03 I;  4P0F A;  4PYW A;  1DVN A;  5CDX A;  1ATT A;  3T1P A;  3DY0 A;  1DB2 A;  4RSQ A;  1C8O A;  2HIJ I;  1DVM A;  2B4X I;  3OZQ A;  1JTI A;  7API A;  3DLW A;  3Q03 A;  1LK6 I;  5CE0 A;  4ROA A;  2RIW A;  1XQJ A;  1UHG A; 
#chains in the Genus database with same CATH homology
 1OVA B;  3B9F I;  1JVQ I;  1DZG I;  1YXA A;  2ARQ A;  1T1F A;  2HIJ L;  2B4X L;  2VH4 A;  3NDD A;  4AU3 B;  4CAA A;  2VDX A;  2WXW A;  3CVM A;  3EVJ I;  3H5C A;  2XN6 A;  1R1L I;  2PEE A;  1BY7 A;  1DZG L;  4AU2 A;  1XQG A;  4AU4 A;  8API A;  4YIA A;  2D26 A;  1B3K A;  4DY0 A;  4C41 A;  1JJO C;  1QLP A;  2B5T I;  1WZ9 A;  4Y3K A;  1LQ8 A;  2ACH A;  1K9O I;  3STO A;  1BR8 I;  4AFX A;  2H4R A;  2OL2 A;  3NDA A;  4ZK0 A;  9PAI A;  3NE4 A;  2ZNH A;  4AJT A;  1LJ5 A;  4KDS A;  5BRR I;  1JMO A;  2R9Y A;  3NDF A;  2HI9 A;  3R4L A;  4C49 A;  3EOX A;  1HLE A;  3PZF A;  4RO9 A;  4ZK3 A;  1MTP A;  3LE2 A;  3VVJ A;  2BEH L;  3FGQ A;  3UT3 A;  1IZ2 A;  2WXZ C;  4P0O A;  3CWM A;  1OPH A;  1OVA C;  1QMB A;  2WXX A;  1OVA A;  1PSI A;  1QMN A;  5CDZ A;  3DRU A;  2ZV6 A;  4AQH A;  1NQ9 I;  1JRR A;  1AZX I;  1SEK A;  4R9I A;  1C5G A;  5C98 A;  2VDY A;  1IMV A;  2XN7 A;  2RIV A;  1OO8 A;  4DTE A;  2BEH I;  1HP7 A;  1ATU A;  1OYH I;  1KCT A;  1SR5 A;  1M93 B;  1XU8 A;  2GD4 C;  2PEF A;  2QUG A;  4IC0 A;  3F02 A;  2WY1 A;  5INW A;  4EB1 I;  1D5S A;  2XN3 A;  3CWL A;  1AS4 A;  1ANT I;  1OYH L;  5EI0 A;  3ZHA A;  2OAY A;  2WXZ A;  3LW2 A;  1TB6 I;  1E04 I;  4EB1 L;  1E05 I;  1SNG A;  9API A;  1JMJ A;  2H4P A;  4AJU A;  4G8R A;  1DZH L;  4AU3 A;  3Q02 A;  4DY7 C;  3CAA A;  1OC0 A;  3F1S A;  1A7C A;  4ROB A;  4BB2 A;  3PB1 I;  4G8O A;  2ANT I;  2XN5 A;  5IO1 A;  1EZX A;  3KCG I;  4Y40 A;  2WXY C;  2ARR A;  3DRM A;  1ATH A;  3F5N A;  2V95 A;  2H4Q A;  4IF8 A;  2WY0 C;  4X30 A;  1DZH I;  2CEO A;  4GA7 A;  1F0C A;  2DUT A;  5HGC A;  1E03 I;  4P0F A;  4PYW A;  1DVN A;  5CDX A;  1ATT A;  3T1P A;  3DY0 A;  1DB2 A;  4RSQ A;  1C8O A;  2HIJ I;  1DVM A;  2B4X I;  3OZQ A;  1JTI A;  7API A;  3DLW A;  3Q03 A;  1LK6 I;  5CE0 A;  4ROA A;  2RIW A;  1XQJ A;  1UHG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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