1P8XA

The calcium-activated c-terminal half of gelsolin
Total Genus 96
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
96
sequence length
330
structure length
316
Chain Sequence
MDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDKKMHPPRLFACEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDNRDRRTPITVVKQGFEPPSFVGWFLGWDDDYW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Activation in isolation: Exposure of the actin-binding site in the C-terminal half of gelsolin does not require actin
pubmed doi rcsb
source organism Homo sapiens
molecule tags Structural protein
molecule keywords Gelsolin precursor, plasma
total genus 96
structure length 316
sequence length 330
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2003-05-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00626 Gelsolin Gelsolin repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 1p8xA01
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 1p8xA03
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 1p8xA02
5KYWB 5KYUB 3EGDB 1CNUA 1M4JA 5FAEA 4CBWG 3EFOA 3A5LS 1WNJA 1SVQA 1F7SA 3TU5B 5FAFA 2LLFA 3CI5G 1M2VA 3Q2BA 4Z94G 1C0FS 1VKKA 1Q8GA 2I2QA 5KYWA 3EGXB 3A5OS 3FFKA 2FF3A 2MOTA 1H1VG 2FGHA 1Q8XA 5IVUA 3CJCG 3FFNA 1EQYS 3EG9B 2XF1A 3EFOB 1ESVS 4KEEA 1NM1G 1T3XA 1YAGG 2FH1A 4JD2H 2NUTB 2VIKA 2KVKA 1D4XG 1RGIG 1P8XA 5KYXA 1UDMA 1JHWA 2D8BA 5KYYB 5L6WC 1QPVA 3A5NS 3EGDA 5KYNA 1SVRA 3EH1A 1PD0A 1DEJS 1AK6A 2QTVA 3EGXA 1WFSA 2LXXA 2W0IA 3FG7A 5A1MA 1NMDG 2MP4A 1D0NA 4KEFA 1KCQA 2NUPA 1J72A 1NPHA 2FH2A 4S10C 3L50A 4BEX1 4CBXG 1T3YA 4PKHB 1YVNG 2VILA 1PD1A 3CJBG 1T2LA 3FG6A 2MV2A 1C0GS 1SVYA 1AHQA 1V6FA 1T44G 2HD7A 1AK7A 4PKIG 3CIPG 4PKGG 1PCXA 1COFA 2L72A 2FH3A 2FF6G 3EG9A 5KYXB 1X67A 5HVKB 3EH2A 5HVKD 1HQZ1 1NLVG 1P8ZG 2NUTA 3A5MS 1VFQA 4KEDA 5KYUA 1CFYA 2LJ8A 2FH4A 5KYYA 5DD2A 3DAWB 2VACA 4LIZA 1TVJA 1MDUA 1WM4A 1M2OA 1M2VB 1TMWA 2NUPB 4CBUG 2XFAA
chains in the Genus database with same CATH superfamily
5KYWB 5KYUB 3EGDB 3DA7A 1CNUA 1M4JA 5FAEA 4CBWG 3EFOA 3A5LS 1WNJA 1SVQA 1F7SA 3TU5B 5FAFA 2LLFA 3CI5G 1M2VA 3Q2BA 4Z94G 1C0FS 1VKKA 1Q8GA 2I2QA 5KYWA 3EGXB 3A5OS 3FFKA 2FF3A 2MOTA 1H1VG 2FGHA 1Q8XA 5IVUA 3CJCG 3FFNA 1EQYS 3EG9B 2XF1A 3EFOB 1ESVS 4KEEA 1NM1G 1T3XA 1YAGG 2FH1A 4JD2H 2NUTB 2VIKA 2KVKA 1D4XG 1RGIG 1P8XA 5KYXA 1UDMA 1JHWA 2D8BA 5KYYB 5L6WC 1QPVA 3A5NS 3EGDA 5KYNA 1SVRA 3EH1A 1PD0A 1DEJS 1AK6A 2QTVA 3EGXA 1WFSA 2LXXA 2W0IA 3FG7A 5A1MA 1NMDG 2MP4A 1D0NA 4KEFA 1KCQA 2NUPA 1J72A 1NPHA 2FH2A 4S10C 3L50A 4BEX1 4CBXG 1T3YA 4PKHB 1YVNG 2VILA 1PD1A 3CJBG 1T2LA 3FG6A 2MV2A 1C0GS 1SVYA 1AHQA 1V6FA 1T44G 2HD7A 1AK7A 4PKIG 3CIPG 4PKGG 1PCXA 1COFA 2L72A 2FH3A 2FF6G 3EG9A 5KYXB 1X67A 5HVKB 3EH2A 5HVKD 1HQZ1 1NLVG 1P8ZG 2NUTA 3A5MS 1VFQA 4KEDA 5KYUA 1CFYA 2LJ8A 2FH4A 5KYYA 5DD2A 3DAWB 2VACA 4LIZA 1TVJA 1MDUA 1WM4A 1M2OA 1M2VB 1TMWA 2NUPB 4CBUG 2XFAA
chains in the Genus database with same CATH topology
5KYWB 5KYUB 3EGDB 3DA7A 1CNUA 1M4JA 5FAEA 4CBWG 3EFOA 3A5LS 1WNJA 1SVQA 1F7SA 3TU5B 5FAFA 2LLFA 3CI5G 1M2VA 3Q2BA 4Z94G 1C0FS 1VKKA 1Q8GA 2I2QA 5KYWA 3EGXB 3A5OS 3FFKA 2FF3A 2MOTA 1H1VG 2FGHA 1Q8XA 5IVUA 3CJCG 3FFNA 1EQYS 3EG9B 2XF1A 3EFOB 1ESVS 4KEEA 1NM1G 1T3XA 1YAGG 2FH1A 4JD2H 2NUTB 2VIKA 2KVKA 1D4XG 1RGIG 1P8XA 5KYXA 1UDMA 1JHWA 2D8BA 5KYYB 5L6WC 1QPVA 3A5NS 3EGDA 5KYNA 1SVRA 3EH1A 1PD0A 1DEJS 1AK6A 2QTVA 3EGXA 1WFSA 2LXXA 2W0IA 3FG7A 5A1MA 1NMDG 2MP4A 1D0NA 4KEFA 1KCQA 2NUPA 1J72A 1NPHA 2FH2A 4S10C 3L50A 4BEX1 4CBXG 1T3YA 4PKHB 1YVNG 2VILA 1PD1A 3CJBG 1T2LA 3FG6A 2MV2A 1C0GS 1SVYA 1AHQA 1V6FA 1T44G 2HD7A 1AK7A 4PKIG 3CIPG 4PKGG 1PCXA 1COFA 2L72A 2FH3A 2FF6G 3EG9A 5KYXB 1X67A 5HVKB 3EH2A 5HVKD 1HQZ1 1NLVG 1P8ZG 2NUTA 3A5MS 1VFQA 4KEDA 5KYUA 1CFYA 2LJ8A 2FH4A 5KYYA 5DD2A 3DAWB 2VACA 4LIZA 1TVJA 1MDUA 1WM4A 1M2OA 1M2VB 1TMWA 2NUPB 4CBUG 2XFAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5KYW B;  5KYU B;  3EGD B;  1CNU A;  1M4J A;  5FAE A;  4CBW G;  3EFO A;  3A5L S;  1WNJ A;  1SVQ A;  1F7S A;  3TU5 B;  5FAF A;  2LLF A;  3CI5 G;  1M2V A;  3Q2B A;  4Z94 G;  1C0F S;  1VKK A;  1Q8G A;  2I2Q A;  5KYW A;  3EGX B;  3A5O S;  3FFK A;  2FF3 A;  2MOT A;  1H1V G;  2FGH A;  1Q8X A;  5IVU A;  3CJC G;  3FFN A;  1EQY S;  3EG9 B;  2XF1 A;  3EFO B;  1ESV S;  4KEE A;  1NM1 G;  1T3X A;  1YAG G;  2FH1 A;  4JD2 H;  2NUT B;  2VIK A;  2KVK A;  1D4X G;  1RGI G;  1P8X A;  5KYX A;  1UDM A;  1JHW A;  2D8B A;  5KYY B;  5L6W C;  1QPV A;  3A5N S;  3EGD A;  5KYN A;  1SVR A;  3EH1 A;  1PD0 A;  1DEJ S;  1AK6 A;  2QTV A;  3EGX A;  1WFS A;  2LXX A;  2W0I A;  3FG7 A;  5A1M A;  1NMD G;  2MP4 A;  1D0N A;  4KEF A;  1KCQ A;  2NUP A;  1J72 A;  1NPH A;  2FH2 A;  4S10 C;  3L50 A;  4BEX 1;  4CBX G;  1T3Y A;  4PKH B;  1YVN G;  2VIL A;  1PD1 A;  3CJB G;  1T2L A;  3FG6 A;  2MV2 A;  1C0G S;  1SVY A;  1AHQ A;  1V6F A;  1T44 G;  2HD7 A;  1AK7 A;  4PKI G;  3CIP G;  4PKG G;  1PCX A;  1COF A;  2L72 A;  2FH3 A;  2FF6 G;  3EG9 A;  5KYX B;  1X67 A;  5HVK B;  3EH2 A;  5HVK D;  1HQZ 1;  1NLV G;  1P8Z G;  2NUT A;  3A5M S;  1VFQ A;  4KED A;  5KYU A;  1CFY A;  2LJ8 A;  2FH4 A;  5KYY A;  5DD2 A;  3DAW B;  2VAC A;  4LIZ A;  1TVJ A;  1MDU A;  1WM4 A;  1M2O A;  1M2V B;  1TMW A;  2NUP B;  4CBU G;  2XFA A; 
#chains in the Genus database with same CATH topology
 5KYW B;  5KYU B;  3EGD B;  3DA7 A;  1CNU A;  1M4J A;  5FAE A;  4CBW G;  3EFO A;  3A5L S;  1WNJ A;  1SVQ A;  1F7S A;  3TU5 B;  5FAF A;  2LLF A;  3CI5 G;  1M2V A;  3Q2B A;  4Z94 G;  1C0F S;  1VKK A;  1Q8G A;  2I2Q A;  5KYW A;  3EGX B;  3A5O S;  3FFK A;  2FF3 A;  2MOT A;  1H1V G;  2FGH A;  1Q8X A;  5IVU A;  3CJC G;  3FFN A;  1EQY S;  3EG9 B;  2XF1 A;  3EFO B;  1ESV S;  4KEE A;  1NM1 G;  1T3X A;  1YAG G;  2FH1 A;  4JD2 H;  2NUT B;  2VIK A;  2KVK A;  1D4X G;  1RGI G;  1P8X A;  5KYX A;  1UDM A;  1JHW A;  2D8B A;  5KYY B;  5L6W C;  1QPV A;  3A5N S;  3EGD A;  5KYN A;  1SVR A;  3EH1 A;  1PD0 A;  1DEJ S;  1AK6 A;  2QTV A;  3EGX A;  1WFS A;  2LXX A;  2W0I A;  3FG7 A;  5A1M A;  1NMD G;  2MP4 A;  1D0N A;  4KEF A;  1KCQ A;  2NUP A;  1J72 A;  1NPH A;  2FH2 A;  4S10 C;  3L50 A;  4BEX 1;  4CBX G;  1T3Y A;  4PKH B;  1YVN G;  2VIL A;  1PD1 A;  3CJB G;  1T2L A;  3FG6 A;  2MV2 A;  1C0G S;  1SVY A;  1AHQ A;  1V6F A;  1T44 G;  2HD7 A;  1AK7 A;  4PKI G;  3CIP G;  4PKG G;  1PCX A;  1COF A;  2L72 A;  2FH3 A;  2FF6 G;  3EG9 A;  5KYX B;  1X67 A;  5HVK B;  3EH2 A;  5HVK D;  1HQZ 1;  1NLV G;  1P8Z G;  2NUT A;  3A5M S;  1VFQ A;  4KED A;  5KYU A;  1CFY A;  2LJ8 A;  2FH4 A;  5KYY A;  5DD2 A;  3DAW B;  2VAC A;  4LIZ A;  1TVJ A;  1MDU A;  1WM4 A;  1M2O A;  1M2V B;  1TMW A;  2NUP B;  4CBU G;  2XFA A; 
#chains in the Genus database with same CATH homology
 5KYW B;  5KYU B;  3EGD B;  3DA7 A;  1CNU A;  1M4J A;  5FAE A;  4CBW G;  3EFO A;  3A5L S;  1WNJ A;  1SVQ A;  1F7S A;  3TU5 B;  5FAF A;  2LLF A;  3CI5 G;  1M2V A;  3Q2B A;  4Z94 G;  1C0F S;  1VKK A;  1Q8G A;  2I2Q A;  5KYW A;  3EGX B;  3A5O S;  3FFK A;  2FF3 A;  2MOT A;  1H1V G;  2FGH A;  1Q8X A;  5IVU A;  3CJC G;  3FFN A;  1EQY S;  3EG9 B;  2XF1 A;  3EFO B;  1ESV S;  4KEE A;  1NM1 G;  1T3X A;  1YAG G;  2FH1 A;  4JD2 H;  2NUT B;  2VIK A;  2KVK A;  1D4X G;  1RGI G;  1P8X A;  5KYX A;  1UDM A;  1JHW A;  2D8B A;  5KYY B;  5L6W C;  1QPV A;  3A5N S;  3EGD A;  5KYN A;  1SVR A;  3EH1 A;  1PD0 A;  1DEJ S;  1AK6 A;  2QTV A;  3EGX A;  1WFS A;  2LXX A;  2W0I A;  3FG7 A;  5A1M A;  1NMD G;  2MP4 A;  1D0N A;  4KEF A;  1KCQ A;  2NUP A;  1J72 A;  1NPH A;  2FH2 A;  4S10 C;  3L50 A;  4BEX 1;  4CBX G;  1T3Y A;  4PKH B;  1YVN G;  2VIL A;  1PD1 A;  3CJB G;  1T2L A;  3FG6 A;  2MV2 A;  1C0G S;  1SVY A;  1AHQ A;  1V6F A;  1T44 G;  2HD7 A;  1AK7 A;  4PKI G;  3CIP G;  4PKG G;  1PCX A;  1COF A;  2L72 A;  2FH3 A;  2FF6 G;  3EG9 A;  5KYX B;  1X67 A;  5HVK B;  3EH2 A;  5HVK D;  1HQZ 1;  1NLV G;  1P8Z G;  2NUT A;  3A5M S;  1VFQ A;  4KED A;  5KYU A;  1CFY A;  2LJ8 A;  2FH4 A;  5KYY A;  5DD2 A;  3DAW B;  2VAC A;  4LIZ A;  1TVJ A;  1MDU A;  1WM4 A;  1M2O A;  1M2V B;  1TMW A;  2NUP B;  4CBU G;  2XFA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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