1P8XA

The calcium-activated c-terminal half of gelsolin
Total Genus 96
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
96
sequence length
330
structure length
316
Chain Sequence
MDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDKKMHPPRLFACEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDNRDRRTPITVVKQGFEPPSFVGWFLGWDDDYW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Activation in isolation: Exposure of the actin-binding site in the C-terminal half of gelsolin does not require actin
pubmed doi rcsb
molecule tags Structural protein
source organism Homo sapiens
molecule keywords Gelsolin precursor, plasma
total genus 96
structure length 316
sequence length 330
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2003-05-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00626 Gelsolin Gelsolin repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 1p8xA01
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 1p8xA03
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 1p8xA02
2FH1A 1AK6A 5HVKB 3EG9A 2FF6G 5KYXB 1AK7A 1MDUA 2FH2A 1SVRA 1Q8XA 1ESVS 2LJ8A 4PKGG 4Z94G 1SVYA 2LLFA 5KYYB 4PKHB 3A5LS 4KEFA 5IVUA 1C0FS 1M4JA 3DAWB 5KYYA 2VILA 2W0IA 3EGDB 3FFNA 5HVKD 2FH4A 1C0GS 1JHWA 4CBUG 3A5NS 5KYWB 4BEX1 1WFSA 3CJCG 3EG9B 2QTVA 3FG6A 1F7SA 1VKKA 1QPVA 1CNUA 1T3XA 3L50A 1TVJA 1NMDG 1J72A 3TU5B 1M2VA 4PKIG 4CBWG 5DD2A 2NUTA 5L6WC 1CFYA 3CJBG 2MV2A 2I2QA 3FFKA 2FH3A 1D0NA 2VACA 3EFOA 2L72A 5KYUA 1TMWA 1WNJA 1NLVG 1P8ZG 1T44G 1H1VG 1X67A 5A1MA 1YVNG 1PD0A 4LIZA 2NUPA 4KEEA 1M2VB 1T2LA 2MP4A 1UDMA 3Q2BA 1WM4A 2NUTB 3EGXA 1PCXA 4KEDA 2KVKA 3EH2A 1RGIG 3EH1A 1COFA 3EFOB 5KYUB 2XF1A 1Q8GA 2LXXA 1T3YA 1HQZ1 1DEJS 3CIPG 2MOTA 1V6FA 1KCQA 3FG7A 5FAFA 2NUPB 1VFQA 4JD2H 1AHQA 2FGHA 2XFAA 5KYXA 4S10C 3A5OS 3EGXB 1M2OA 5FAEA 1PD1A 1YAGG 1SVQA 1NM1G 2HD7A 2FF3A 2D8BA 1NPHA 4CBXG 5KYNA 1D4XG 2VIKA 3CI5G 3A5MS 1EQYS 3EGDA 1P8XA 5KYWA
chains in the Genus database with same CATH superfamily
2FH1A 1AK6A 5HVKB 3EG9A 2FF6G 5KYXB 1AK7A 1MDUA 2FH2A 1SVRA 1Q8XA 1ESVS 2LJ8A 4PKGG 4Z94G 1SVYA 2LLFA 5KYYB 4PKHB 3A5LS 4KEFA 5IVUA 1C0FS 1M4JA 3DAWB 5KYYA 2VILA 2W0IA 3EGDB 3FFNA 5HVKD 2FH4A 1C0GS 1JHWA 4CBUG 3A5NS 5KYWB 4BEX1 1WFSA 3CJCG 3EG9B 2QTVA 3FG6A 1F7SA 1VKKA 1QPVA 1CNUA 1T3XA 3L50A 1TVJA 1NMDG 1J72A 3TU5B 1M2VA 4PKIG 4CBWG 5DD2A 2NUTA 5L6WC 1CFYA 3CJBG 2MV2A 2I2QA 3FFKA 2FH3A 1D0NA 2VACA 3EFOA 2L72A 5KYUA 1TMWA 1WNJA 1NLVG 1P8ZG 1T44G 1H1VG 1X67A 5A1MA 1YVNG 1PD0A 4LIZA 2NUPA 4KEEA 1M2VB 1T2LA 2MP4A 1UDMA 3Q2BA 1WM4A 2NUTB 3EGXA 1PCXA 4KEDA 2KVKA 3EH2A 1RGIG 3EH1A 1COFA 3EFOB 5KYUB 2XF1A 3DA7A 1Q8GA 2LXXA 1T3YA 1HQZ1 1DEJS 3CIPG 2MOTA 1V6FA 1KCQA 3FG7A 5FAFA 2NUPB 1VFQA 4JD2H 1AHQA 2FGHA 2XFAA 5KYXA 4S10C 3A5OS 3EGXB 1M2OA 5FAEA 1PD1A 1YAGG 1SVQA 1NM1G 2HD7A 2FF3A 2D8BA 1NPHA 4CBXG 5KYNA 1D4XG 2VIKA 3CI5G 3A5MS 1EQYS 3EGDA 1P8XA 5KYWA
chains in the Genus database with same CATH topology
2FH1A 1AK6A 5HVKB 3EG9A 2FF6G 5KYXB 1AK7A 1MDUA 2FH2A 1SVRA 1Q8XA 1ESVS 2LJ8A 4PKGG 4Z94G 1SVYA 2LLFA 5KYYB 4PKHB 3A5LS 4KEFA 5IVUA 1C0FS 1M4JA 3DAWB 5KYYA 2VILA 2W0IA 3EGDB 3FFNA 5HVKD 2FH4A 1C0GS 1JHWA 4CBUG 3A5NS 5KYWB 4BEX1 1WFSA 3CJCG 3EG9B 2QTVA 3FG6A 1F7SA 1VKKA 1QPVA 1CNUA 1T3XA 3L50A 1TVJA 1NMDG 1J72A 3TU5B 1M2VA 4PKIG 4CBWG 5DD2A 2NUTA 5L6WC 1CFYA 3CJBG 2MV2A 2I2QA 3FFKA 2FH3A 1D0NA 2VACA 3EFOA 2L72A 5KYUA 1TMWA 1WNJA 1NLVG 1P8ZG 1T44G 1H1VG 1X67A 5A1MA 1YVNG 1PD0A 4LIZA 2NUPA 4KEEA 1M2VB 1T2LA 2MP4A 1UDMA 3Q2BA 1WM4A 2NUTB 3EGXA 1PCXA 4KEDA 2KVKA 3EH2A 1RGIG 3EH1A 1COFA 3EFOB 5KYUB 2XF1A 3DA7A 1Q8GA 2LXXA 1T3YA 1HQZ1 1DEJS 3CIPG 2MOTA 1V6FA 1KCQA 3FG7A 5FAFA 2NUPB 1VFQA 4JD2H 1AHQA 2FGHA 2XFAA 5KYXA 4S10C 3A5OS 3EGXB 1M2OA 5FAEA 1PD1A 1YAGG 1SVQA 1NM1G 2HD7A 2FF3A 2D8BA 1NPHA 4CBXG 5KYNA 1D4XG 2VIKA 3CI5G 3A5MS 1EQYS 3EGDA 1P8XA 5KYWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FH1 A;  1AK6 A;  5HVK B;  3EG9 A;  2FF6 G;  5KYX B;  1AK7 A;  1MDU A;  2FH2 A;  1SVR A;  1Q8X A;  1ESV S;  2LJ8 A;  4PKG G;  4Z94 G;  1SVY A;  2LLF A;  5KYY B;  4PKH B;  3A5L S;  4KEF A;  5IVU A;  1C0F S;  1M4J A;  3DAW B;  5KYY A;  2VIL A;  2W0I A;  3EGD B;  3FFN A;  5HVK D;  2FH4 A;  1C0G S;  1JHW A;  4CBU G;  3A5N S;  5KYW B;  4BEX 1;  1WFS A;  3CJC G;  3EG9 B;  2QTV A;  3FG6 A;  1F7S A;  1VKK A;  1QPV A;  1CNU A;  1T3X A;  3L50 A;  1TVJ A;  1NMD G;  1J72 A;  3TU5 B;  1M2V A;  4PKI G;  4CBW G;  5DD2 A;  2NUT A;  5L6W C;  1CFY A;  3CJB G;  2MV2 A;  2I2Q A;  3FFK A;  2FH3 A;  1D0N A;  2VAC A;  3EFO A;  2L72 A;  5KYU A;  1TMW A;  1WNJ A;  1NLV G;  1P8Z G;  1T44 G;  1H1V G;  1X67 A;  5A1M A;  1YVN G;  1PD0 A;  4LIZ A;  2NUP A;  4KEE A;  1M2V B;  1T2L A;  2MP4 A;  1UDM A;  3Q2B A;  1WM4 A;  2NUT B;  3EGX A;  1PCX A;  4KED A;  2KVK A;  3EH2 A;  1RGI G;  3EH1 A;  1COF A;  3EFO B;  5KYU B;  2XF1 A;  1Q8G A;  2LXX A;  1T3Y A;  1HQZ 1;  1DEJ S;  3CIP G;  2MOT A;  1V6F A;  1KCQ A;  3FG7 A;  5FAF A;  2NUP B;  1VFQ A;  4JD2 H;  1AHQ A;  2FGH A;  2XFA A;  5KYX A;  4S10 C;  3A5O S;  3EGX B;  1M2O A;  5FAE A;  1PD1 A;  1YAG G;  1SVQ A;  1NM1 G;  2HD7 A;  2FF3 A;  2D8B A;  1NPH A;  4CBX G;  5KYN A;  1D4X G;  2VIK A;  3CI5 G;  3A5M S;  1EQY S;  3EGD A;  1P8X A;  5KYW A; 
#chains in the Genus database with same CATH topology
 2FH1 A;  1AK6 A;  5HVK B;  3EG9 A;  2FF6 G;  5KYX B;  1AK7 A;  1MDU A;  2FH2 A;  1SVR A;  1Q8X A;  1ESV S;  2LJ8 A;  4PKG G;  4Z94 G;  1SVY A;  2LLF A;  5KYY B;  4PKH B;  3A5L S;  4KEF A;  5IVU A;  1C0F S;  1M4J A;  3DAW B;  5KYY A;  2VIL A;  2W0I A;  3EGD B;  3FFN A;  5HVK D;  2FH4 A;  1C0G S;  1JHW A;  4CBU G;  3A5N S;  5KYW B;  4BEX 1;  1WFS A;  3CJC G;  3EG9 B;  2QTV A;  3FG6 A;  1F7S A;  1VKK A;  1QPV A;  1CNU A;  1T3X A;  3L50 A;  1TVJ A;  1NMD G;  1J72 A;  3TU5 B;  1M2V A;  4PKI G;  4CBW G;  5DD2 A;  2NUT A;  5L6W C;  1CFY A;  3CJB G;  2MV2 A;  2I2Q A;  3FFK A;  2FH3 A;  1D0N A;  2VAC A;  3EFO A;  2L72 A;  5KYU A;  1TMW A;  1WNJ A;  1NLV G;  1P8Z G;  1T44 G;  1H1V G;  1X67 A;  5A1M A;  1YVN G;  1PD0 A;  4LIZ A;  2NUP A;  4KEE A;  1M2V B;  1T2L A;  2MP4 A;  1UDM A;  3Q2B A;  1WM4 A;  2NUT B;  3EGX A;  1PCX A;  4KED A;  2KVK A;  3EH2 A;  1RGI G;  3EH1 A;  1COF A;  3EFO B;  5KYU B;  2XF1 A;  3DA7 A;  1Q8G A;  2LXX A;  1T3Y A;  1HQZ 1;  1DEJ S;  3CIP G;  2MOT A;  1V6F A;  1KCQ A;  3FG7 A;  5FAF A;  2NUP B;  1VFQ A;  4JD2 H;  1AHQ A;  2FGH A;  2XFA A;  5KYX A;  4S10 C;  3A5O S;  3EGX B;  1M2O A;  5FAE A;  1PD1 A;  1YAG G;  1SVQ A;  1NM1 G;  2HD7 A;  2FF3 A;  2D8B A;  1NPH A;  4CBX G;  5KYN A;  1D4X G;  2VIK A;  3CI5 G;  3A5M S;  1EQY S;  3EGD A;  1P8X A;  5KYW A; 
#chains in the Genus database with same CATH homology
 2FH1 A;  1AK6 A;  5HVK B;  3EG9 A;  2FF6 G;  5KYX B;  1AK7 A;  1MDU A;  2FH2 A;  1SVR A;  1Q8X A;  1ESV S;  2LJ8 A;  4PKG G;  4Z94 G;  1SVY A;  2LLF A;  5KYY B;  4PKH B;  3A5L S;  4KEF A;  5IVU A;  1C0F S;  1M4J A;  3DAW B;  5KYY A;  2VIL A;  2W0I A;  3EGD B;  3FFN A;  5HVK D;  2FH4 A;  1C0G S;  1JHW A;  4CBU G;  3A5N S;  5KYW B;  4BEX 1;  1WFS A;  3CJC G;  3EG9 B;  2QTV A;  3FG6 A;  1F7S A;  1VKK A;  1QPV A;  1CNU A;  1T3X A;  3L50 A;  1TVJ A;  1NMD G;  1J72 A;  3TU5 B;  1M2V A;  4PKI G;  4CBW G;  5DD2 A;  2NUT A;  5L6W C;  1CFY A;  3CJB G;  2MV2 A;  2I2Q A;  3FFK A;  2FH3 A;  1D0N A;  2VAC A;  3EFO A;  2L72 A;  5KYU A;  1TMW A;  1WNJ A;  1NLV G;  1P8Z G;  1T44 G;  1H1V G;  1X67 A;  5A1M A;  1YVN G;  1PD0 A;  4LIZ A;  2NUP A;  4KEE A;  1M2V B;  1T2L A;  2MP4 A;  1UDM A;  3Q2B A;  1WM4 A;  2NUT B;  3EGX A;  1PCX A;  4KED A;  2KVK A;  3EH2 A;  1RGI G;  3EH1 A;  1COF A;  3EFO B;  5KYU B;  2XF1 A;  3DA7 A;  1Q8G A;  2LXX A;  1T3Y A;  1HQZ 1;  1DEJ S;  3CIP G;  2MOT A;  1V6F A;  1KCQ A;  3FG7 A;  5FAF A;  2NUP B;  1VFQ A;  4JD2 H;  1AHQ A;  2FGH A;  2XFA A;  5KYX A;  4S10 C;  3A5O S;  3EGX B;  1M2O A;  5FAE A;  1PD1 A;  1YAG G;  1SVQ A;  1NM1 G;  2HD7 A;  2FF3 A;  2D8B A;  1NPH A;  4CBX G;  5KYN A;  1D4X G;  2VIK A;  3CI5 G;  3A5M S;  1EQY S;  3EGD A;  1P8X A;  5KYW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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