1PK2A

Solution structure of the tissue-type plasminogen activator kringle 2 domain complexed to 6-aminohexanoic acid an antifibrinolytic drug
Total Genus 13
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
13
sequence length
90
structure length
90
Chain Sequence
SEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCST
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Plasminogen activator
molecule keywords TISSUE-TYPE PLASMINOGEN ACTIVATOR
publication title Solution structure of the tissue-type plasminogen activator kringle 2 domain complexed to 6-aminohexanoic acid an antifibrinolytic drug.
pubmed doi rcsb
source organism Homo sapiens
total genus 13
structure length 90
sequence length 90
ec nomenclature ec 3.4.21.68: T-plasminogen activator.
pdb deposition date 1991-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 1pk2A00
3E6PL 2KNFA 2K4RA 2HPPP 4BVWA 2KJ4A 1PKRA 4O03A 4BVVA 3K65A 1A0HA 1B2IA 5COEA 1KI0A 1NL1A 1PMKA 1CEAA 1I71A 3U73A 1HPJA 4BV7A 4HZHA 4IUAA 3LAQA 2DOHX 5CS9A 1NL2A 2PF1A 3KIVA 1GMNA 2SPTA 3NXPA 1I5KA 3HN4A 1KIVA 1GP9A 1JFNA 2PF2A 4DURA 3BT2A 4KIVA 5CT3A 3MKPA 1GMOA 5CS1A 2QJ2A 2I9BA 5CS3A 3SP8A 2FEBA 1KRNA 4BVDA 4CIKA 5HPGA 5CT1A 1PK2A 3BT1A 1HPKA 5CP9A 2I9AA 4NZQA 1TPKA 4A5TS 1KDUA 2HPQP 5CT2A 2L0SA 5CSQA 1PMLA 2PK4A 1NK1A 4D3CA 4BVCA 4BV5A 2QJ4A 1PK4A 1URKA 1CEBA 2K51A 1BHTA 5CS5A 2DOIA 2FD6A
chains in the Genus database with same CATH superfamily
3E6PL 2KNFA 2K4RA 2HPPP 4BVWA 2KJ4A 1PKRA 4O03A 4BVVA 3K65A 1A0HA 1B2IA 5COEA 1KI0A 1NL1A 1PMKA 1CEAA 1I71A 3U73A 1HPJA 4BV7A 4HZHA 4IUAA 3LAQA 2DOHX 5CS9A 1NL2A 2PF1A 3KIVA 1GMNA 2SPTA 3NXPA 1I5KA 3HN4A 1KIVA 1GP9A 1JFNA 2PF2A 4DURA 3BT2A 4KIVA 5CT3A 3MKPA 1GMOA 5CS1A 2QJ2A 2I9BA 5CS3A 3SP8A 2FEBA 1KRNA 4BVDA 4CIKA 5HPGA 5CT1A 1PK2A 3BT1A 1HPKA 5CP9A 2I9AA 4NZQA 1TPKA 4A5TS 1KDUA 2HPQP 5CT2A 2L0SA 5CSQA 1PMLA 2PK4A 1NK1A 4D3CA 4BVCA 4BV5A 2QJ4A 1PK4A 1URKA 1CEBA 2K51A 1BHTA 5CS5A 2DOIA 2FD6A
chains in the Genus database with same CATH topology
3E6PL 2KNFA 2K4RA 2HPPP 4BVWA 2KJ4A 1PKRA 4O03A 4BVVA 3K65A 1A0HA 1B2IA 5COEA 1KI0A 1NL1A 1PMKA 1CEAA 1I71A 3U73A 1HPJA 4BV7A 4HZHA 4IUAA 3LAQA 2DOHX 5CS9A 1NL2A 2PF1A 3KIVA 1GMNA 2SPTA 3NXPA 1I5KA 3HN4A 1KIVA 1GP9A 1JFNA 2PF2A 4DURA 3BT2A 4KIVA 5CT3A 3MKPA 1GMOA 5CS1A 2QJ2A 2I9BA 5CS3A 3SP8A 2FEBA 1KRNA 4BVDA 4CIKA 5HPGA 5CT1A 1PK2A 3BT1A 1HPKA 5CP9A 2I9AA 4NZQA 1TPKA 4A5TS 1KDUA 2HPQP 5CT2A 2L0SA 5CSQA 1PMLA 2PK4A 1NK1A 4D3CA 4BVCA 4BV5A 2QJ4A 1PK4A 1URKA 1CEBA 2K51A 1BHTA 5CS5A 2DOIA 2FD6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3E6P L;  2KNF A;  2K4R A;  2HPP P;  4BVW A;  2KJ4 A;  1PKR A;  4O03 A;  4BVV A;  3K65 A;  1A0H A;  1B2I A;  5COE A;  1KI0 A;  1NL1 A;  1PMK A;  1CEA A;  1I71 A;  3U73 A;  1HPJ A;  4BV7 A;  4HZH A;  4IUA A;  3LAQ A;  2DOH X;  5CS9 A;  1NL2 A;  2PF1 A;  3KIV A;  1GMN A;  2SPT A;  3NXP A;  1I5K A;  3HN4 A;  1KIV A;  1GP9 A;  1JFN A;  2PF2 A;  4DUR A;  3BT2 A;  4KIV A;  5CT3 A;  3MKP A;  1GMO A;  5CS1 A;  2QJ2 A;  2I9B A;  5CS3 A;  3SP8 A;  2FEB A;  1KRN A;  4BVD A;  4CIK A;  5HPG A;  5CT1 A;  1PK2 A;  3BT1 A;  1HPK A;  5CP9 A;  2I9A A;  4NZQ A;  1TPK A;  4A5T S;  1KDU A;  2HPQ P;  5CT2 A;  2L0S A;  5CSQ A;  1PML A;  2PK4 A;  1NK1 A;  4D3C A;  4BVC A;  4BV5 A;  2QJ4 A;  1PK4 A;  1URK A;  1CEB A;  2K51 A;  1BHT A;  5CS5 A;  2DOI A;  2FD6 A; 
#chains in the Genus database with same CATH topology
 3E6P L;  2KNF A;  2K4R A;  2HPP P;  4BVW A;  2KJ4 A;  1PKR A;  4O03 A;  4BVV A;  3K65 A;  1A0H A;  1B2I A;  5COE A;  1KI0 A;  1NL1 A;  1PMK A;  1CEA A;  1I71 A;  3U73 A;  1HPJ A;  4BV7 A;  4HZH A;  4IUA A;  3LAQ A;  2DOH X;  5CS9 A;  1NL2 A;  2PF1 A;  3KIV A;  1GMN A;  2SPT A;  3NXP A;  1I5K A;  3HN4 A;  1KIV A;  1GP9 A;  1JFN A;  2PF2 A;  4DUR A;  3BT2 A;  4KIV A;  5CT3 A;  3MKP A;  1GMO A;  5CS1 A;  2QJ2 A;  2I9B A;  5CS3 A;  3SP8 A;  2FEB A;  1KRN A;  4BVD A;  4CIK A;  5HPG A;  5CT1 A;  1PK2 A;  3BT1 A;  1HPK A;  5CP9 A;  2I9A A;  4NZQ A;  1TPK A;  4A5T S;  1KDU A;  2HPQ P;  5CT2 A;  2L0S A;  5CSQ A;  1PML A;  2PK4 A;  1NK1 A;  4D3C A;  4BVC A;  4BV5 A;  2QJ4 A;  1PK4 A;  1URK A;  1CEB A;  2K51 A;  1BHT A;  5CS5 A;  2DOI A;  2FD6 A; 
#chains in the Genus database with same CATH homology
 3E6P L;  2KNF A;  2K4R A;  2HPP P;  4BVW A;  2KJ4 A;  1PKR A;  4O03 A;  4BVV A;  3K65 A;  1A0H A;  1B2I A;  5COE A;  1KI0 A;  1NL1 A;  1PMK A;  1CEA A;  1I71 A;  3U73 A;  1HPJ A;  4BV7 A;  4HZH A;  4IUA A;  3LAQ A;  2DOH X;  5CS9 A;  1NL2 A;  2PF1 A;  3KIV A;  1GMN A;  2SPT A;  3NXP A;  1I5K A;  3HN4 A;  1KIV A;  1GP9 A;  1JFN A;  2PF2 A;  4DUR A;  3BT2 A;  4KIV A;  5CT3 A;  3MKP A;  1GMO A;  5CS1 A;  2QJ2 A;  2I9B A;  5CS3 A;  3SP8 A;  2FEB A;  1KRN A;  4BVD A;  4CIK A;  5HPG A;  5CT1 A;  1PK2 A;  3BT1 A;  1HPK A;  5CP9 A;  2I9A A;  4NZQ A;  1TPK A;  4A5T S;  1KDU A;  2HPQ P;  5CT2 A;  2L0S A;  5CSQ A;  1PML A;  2PK4 A;  1NK1 A;  4D3C A;  4BVC A;  4BV5 A;  2QJ4 A;  1PK4 A;  1URK A;  1CEB A;  2K51 A;  1BHT A;  5CS5 A;  2DOI A;  2FD6 A; 
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#similar chains, but unknotted
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