1QXZA

Crystal structure of s. aureus methionine aminopeptidase in complex with a ketoheterocycle inhibitor 119
Total Genus 81
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
81
sequence length
249
structure length
249
Chain Sequence
MIVKTEEELQALKEIGYICAKVRNTMQAATKPGITTKELDNIAKELFEEYGAISAPIHDENFPGQTCISVNEEVAHGIPSKRVIREGDLVNIDVSALKNGYYADTGISFVVGESDDPMKQKVCDVATMAFENAIAKVKPGTKLSNIGKAVHNTARQNDLKVIKNLTGHGVGLSLHEAPAHVLNYFDPKDKTLLTEGMVLAIEPFISSNASFVTEGKNEWAFETSDKSFVAQIEHTVIVTKDGPILTTKI
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate.
pubmed doi rcsb
molecule tags Hydrolase
source organism Staphylococcus aureus
molecule keywords methionyl aminopeptidase
total genus 81
structure length 249
sequence length 249
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2003-09-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 1qxzA00
2V3XA 2EA2A 1WKMA 3PKBA 4U6EA 3L24A 3MATA 2BH3A 2P99A 3PKAA 2ZSGA 4U73A 1WLRA 2B3HA 4S2RP 3BITA 2OAZA 2HOWA 4PV4A 4KM3A 1XGSA 3CTZA 4IPAA 2OKNA 3BIQA 4MATA 1WN1A 4U70A 1WBQA 1B59A 2BWYA 4IECA 2GU7A 2GG8A 2BHAA 2MATA 3FMRA 1M35A 4PNCA 4U6JA 2GGCA 1CHMA 4FUKA 4FLKA 2BWSA 4FLIA 4A6VA 3RVAA 2BWXA 2Q93A 2BHBA 4FLLA 3PKEA 2EVCA 5FCFA 4FKCA 1XGNA 4IDYA 1C21A 1BOAA 2GG5A 5JI6A 4IKUA 4U69A 3IU9A 4S2TP 1KQ9A 2Q95A 2GG3A 4JUQA 1Y1NA 5CDVA 2GG2A 2EVOA 1QXWA 4HXXA 3TAVA 2EA4A 2NQ6A 1C24A 3MX6A 1MATA 1W2MA 4IU6A 4ZWPA 4ZWUA 1QZYA 2GU4A 2GG7A 1C23A 5CDEA 2GZ5A 2V3ZA 1C22A 3CB6A 5JFRA 5CDLA 1WL9A 2GU6A 4IKSA 1YW7A 1XGOA 1O0XA 4IKRA 1KQ0A 1C27A 3MR1A 5CLSA 4U6WA 5FCHA 1R5HA 2Q96A 4A6WA 4Z7MA 2P9AA 1N51A 2IW2A 4S00A 4QR8A 5D6EA 2GU5A 2BWVA 1QXZA 1PV9A 4RZZA 4U71A 5D6FA 4IKTA 2BHCA 2P98A 3CB5A 3IG4A 3TB5A 2GTXA 4U75A 1QXYA 1BN5A 2BHDA 2ADUA 2BWUA 2DFIA 4U76A 2GG9A 2EVMA 3IU8A 4OOKA 1W7VA 2B3LA 2V3YA 4FLJA 2GA2A 1R58A 3IU7A 2BB7A 2Q94A 4FO7A 4EGEA 1R5GA 1JAWA 3Q6DA 4ZNGA 3PKCA 3FM3A 4RGZ1 5JHUA 4FO8A 2NQ7A 4RZYA 1WL6A 2Q8KA 4U6CA 1XGMA 2GGBA 4B28A 1XNZA 1B6AA 4R60A 1YW9A 5E5BA 1YW8A 2BN7A 2GG0A 3S6BA 2B3KA 4U6ZA 4ZWOA 4IF7A 2BWTA 2G6PA 3FMQA 3D27A 4S01A 4U1BA 2BWWA 1WY2A 3BIPA 2V6CA 3RORA 5CE6A 1KP0A 1YJ3A 3L7GA 2Q92A 5CIKA 3PKDA 1A16A 5CNXA 1YVMA
chains in the Genus database with same CATH superfamily
2V3XA 2EA2A 1WKMA 3PKBA 4U6EA 3L24A 3MATA 2BH3A 2P99A 3PKAA 2ZSGA 4U73A 1WLRA 2B3HA 4S2RP 3BITA 2OAZA 2HOWA 4PV4A 4KM3A 1XGSA 3CTZA 4IPAA 2OKNA 3BIQA 4MATA 1WN1A 4U70A 1WBQA 1B59A 2BWYA 4IECA 2GU7A 2GG8A 2BHAA 2MATA 3FMRA 1M35A 4PNCA 4U6JA 2GGCA 1CHMA 4FUKA 4FLKA 2BWSA 4FLIA 4A6VA 3RVAA 2BWXA 2Q93A 2BHBA 4FLLA 3PKEA 2EVCA 5FCFA 4FKCA 1XGNA 4IDYA 1C21A 1BOAA 2GG5A 5JI6A 4IKUA 4U69A 3IU9A 4S2TP 1KQ9A 2Q95A 2GG3A 4JUQA 1Y1NA 5CDVA 2GG2A 2EVOA 1QXWA 4HXXA 3TAVA 2EA4A 2NQ6A 1C24A 3MX6A 1MATA 1W2MA 4IU6A 4ZWPA 4ZWUA 1QZYA 2GU4A 2GG7A 1C23A 5CDEA 2GZ5A 2V3ZA 1C22A 3CB6A 5JFRA 5CDLA 1WL9A 2GU6A 4IKSA 1YW7A 1XGOA 1O0XA 4IKRA 1KQ0A 1C27A 3MR1A 5CLSA 4U6WA 5FCHA 1R5HA 2Q96A 4A6WA 4Z7MA 2P9AA 1N51A 2IW2A 4S00A 4QR8A 5D6EA 2GU5A 2BWVA 1QXZA 1PV9A 4RZZA 4U71A 5D6FA 4IKTA 2BHCA 2P98A 3CB5A 3IG4A 3TB5A 2GTXA 4U75A 1QXYA 1BN5A 2BHDA 2ADUA 2BWUA 2DFIA 4U76A 2GG9A 2EVMA 3IU8A 4OOKA 1W7VA 2B3LA 2V3YA 4FLJA 2GA2A 1R58A 3IU7A 2BB7A 2Q94A 4FO7A 4EGEA 1R5GA 1JAWA 3Q6DA 4ZNGA 3PKCA 3FM3A 4RGZ1 5JHUA 4FO8A 2NQ7A 4RZYA 1WL6A 2Q8KA 4U6CA 1XGMA 2GGBA 4B28A 1XNZA 1B6AA 4R60A 1YW9A 5E5BA 1YW8A 2BN7A 2GG0A 3S6BA 2B3KA 4U6ZA 4ZWOA 4IF7A 2BWTA 2G6PA 3FMQA 3D27A 4S01A 4U1BA 2BWWA 1WY2A 3BIPA 2V6CA 3RORA 5CE6A 1KP0A 1YJ3A 3L7GA 2Q92A 5CIKA 3PKDA 1A16A 5CNXA 1YVMA
chains in the Genus database with same CATH topology
2V3XA 2EA2A 1WKMA 3PKBA 4U6EA 3L24A 3MATA 2BH3A 2P99A 3PKAA 2ZSGA 4U73A 1WLRA 2B3HA 4S2RP 3BITA 2OAZA 2HOWA 4PV4A 4KM3A 1XGSA 3CTZA 4IPAA 2OKNA 3BIQA 4MATA 1WN1A 4U70A 1WBQA 1B59A 2BWYA 4IECA 2GU7A 2GG8A 2BHAA 2MATA 3FMRA 1M35A 4PNCA 4U6JA 2GGCA 1CHMA 4FUKA 4FLKA 2BWSA 4FLIA 4A6VA 3RVAA 2BWXA 2Q93A 2BHBA 4FLLA 3PKEA 2EVCA 5FCFA 4FKCA 1XGNA 4IDYA 1C21A 1BOAA 2GG5A 5JI6A 4IKUA 4U69A 3IU9A 4S2TP 1KQ9A 2Q95A 2GG3A 4JUQA 1Y1NA 5CDVA 2GG2A 2EVOA 1QXWA 4HXXA 3TAVA 2EA4A 2NQ6A 1C24A 3MX6A 1MATA 1W2MA 4IU6A 4ZWPA 4ZWUA 1QZYA 2GU4A 2GG7A 1C23A 5CDEA 2GZ5A 2V3ZA 1C22A 3CB6A 5JFRA 5CDLA 1WL9A 2GU6A 4IKSA 1YW7A 1XGOA 1O0XA 4IKRA 1KQ0A 1C27A 3MR1A 5CLSA 4U6WA 5FCHA 1R5HA 2Q96A 4A6WA 4Z7MA 2P9AA 1N51A 2IW2A 4S00A 4QR8A 5D6EA 2GU5A 2BWVA 1QXZA 1PV9A 4RZZA 4U71A 5D6FA 4IKTA 2BHCA 2P98A 3CB5A 3IG4A 3TB5A 2GTXA 4U75A 1QXYA 1BN5A 2BHDA 2ADUA 2BWUA 2DFIA 4U76A 2GG9A 2EVMA 3IU8A 4OOKA 1W7VA 2B3LA 2V3YA 4FLJA 2GA2A 1R58A 3IU7A 2BB7A 2Q94A 4FO7A 4EGEA 1R5GA 1JAWA 3Q6DA 4ZNGA 3PKCA 3FM3A 4RGZ1 5JHUA 4FO8A 2NQ7A 4RZYA 1WL6A 2Q8KA 4U6CA 1XGMA 2GGBA 4B28A 1XNZA 1B6AA 4R60A 1YW9A 5E5BA 1YW8A 2BN7A 2GG0A 3S6BA 2B3KA 4U6ZA 4ZWOA 4IF7A 2BWTA 2G6PA 3FMQA 3D27A 4S01A 4U1BA 2BWWA 1WY2A 3BIPA 2V6CA 3RORA 5CE6A 1KP0A 1YJ3A 3L7GA 2Q92A 5CIKA 3PKDA 1A16A 5CNXA 1YVMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2V3X A;  2EA2 A;  1WKM A;  3PKB A;  4U6E A;  3L24 A;  3MAT A;  2BH3 A;  2P99 A;  3PKA A;  2ZSG A;  4U73 A;  1WLR A;  2B3H A;  4S2R P;  3BIT A;  2OAZ A;  2HOW A;  4PV4 A;  4KM3 A;  1XGS A;  3CTZ A;  4IPA A;  2OKN A;  3BIQ A;  4MAT A;  1WN1 A;  4U70 A;  1WBQ A;  1B59 A;  2BWY A;  4IEC A;  2GU7 A;  2GG8 A;  2BHA A;  2MAT A;  3FMR A;  1M35 A;  4PNC A;  4U6J A;  2GGC A;  1CHM A;  4FUK A;  4FLK A;  2BWS A;  4FLI A;  4A6V A;  3RVA A;  2BWX A;  2Q93 A;  2BHB A;  4FLL A;  3PKE A;  2EVC A;  5FCF A;  4FKC A;  1XGN A;  4IDY A;  1C21 A;  1BOA A;  2GG5 A;  5JI6 A;  4IKU A;  4U69 A;  3IU9 A;  4S2T P;  1KQ9 A;  2Q95 A;  2GG3 A;  4JUQ A;  1Y1N A;  5CDV A;  2GG2 A;  2EVO A;  1QXW A;  4HXX A;  3TAV A;  2EA4 A;  2NQ6 A;  1C24 A;  3MX6 A;  1MAT A;  1W2M A;  4IU6 A;  4ZWP A;  4ZWU A;  1QZY A;  2GU4 A;  2GG7 A;  1C23 A;  5CDE A;  2GZ5 A;  2V3Z A;  1C22 A;  3CB6 A;  5JFR A;  5CDL A;  1WL9 A;  2GU6 A;  4IKS A;  1YW7 A;  1XGO A;  1O0X A;  4IKR A;  1KQ0 A;  1C27 A;  3MR1 A;  5CLS A;  4U6W A;  5FCH A;  1R5H A;  2Q96 A;  4A6W A;  4Z7M A;  2P9A A;  1N51 A;  2IW2 A;  4S00 A;  4QR8 A;  5D6E A;  2GU5 A;  2BWV A;  1QXZ A;  1PV9 A;  4RZZ A;  4U71 A;  5D6F A;  4IKT A;  2BHC A;  2P98 A;  3CB5 A;  3IG4 A;  3TB5 A;  2GTX A;  4U75 A;  1QXY A;  1BN5 A;  2BHD A;  2ADU A;  2BWU A;  2DFI A;  4U76 A;  2GG9 A;  2EVM A;  3IU8 A;  4OOK A;  1W7V A;  2B3L A;  2V3Y A;  4FLJ A;  2GA2 A;  1R58 A;  3IU7 A;  2BB7 A;  2Q94 A;  4FO7 A;  4EGE A;  1R5G A;  1JAW A;  3Q6D A;  4ZNG A;  3PKC A;  3FM3 A;  4RGZ 1;  5JHU A;  4FO8 A;  2NQ7 A;  4RZY A;  1WL6 A;  2Q8K A;  4U6C A;  1XGM A;  2GGB A;  4B28 A;  1XNZ A;  1B6A A;  4R60 A;  1YW9 A;  5E5B A;  1YW8 A;  2BN7 A;  2GG0 A;  3S6B A;  2B3K A;  4U6Z A;  4ZWO A;  4IF7 A;  2BWT A;  2G6P A;  3FMQ A;  3D27 A;  4S01 A;  4U1B A;  2BWW A;  1WY2 A;  3BIP A;  2V6C A;  3ROR A;  5CE6 A;  1KP0 A;  1YJ3 A;  3L7G A;  2Q92 A;  5CIK A;  3PKD A;  1A16 A;  5CNX A;  1YVM A; 
#chains in the Genus database with same CATH topology
 2V3X A;  2EA2 A;  1WKM A;  3PKB A;  4U6E A;  3L24 A;  3MAT A;  2BH3 A;  2P99 A;  3PKA A;  2ZSG A;  4U73 A;  1WLR A;  2B3H A;  4S2R P;  3BIT A;  2OAZ A;  2HOW A;  4PV4 A;  4KM3 A;  1XGS A;  3CTZ A;  4IPA A;  2OKN A;  3BIQ A;  4MAT A;  1WN1 A;  4U70 A;  1WBQ A;  1B59 A;  2BWY A;  4IEC A;  2GU7 A;  2GG8 A;  2BHA A;  2MAT A;  3FMR A;  1M35 A;  4PNC A;  4U6J A;  2GGC A;  1CHM A;  4FUK A;  4FLK A;  2BWS A;  4FLI A;  4A6V A;  3RVA A;  2BWX A;  2Q93 A;  2BHB A;  4FLL A;  3PKE A;  2EVC A;  5FCF A;  4FKC A;  1XGN A;  4IDY A;  1C21 A;  1BOA A;  2GG5 A;  5JI6 A;  4IKU A;  4U69 A;  3IU9 A;  4S2T P;  1KQ9 A;  2Q95 A;  2GG3 A;  4JUQ A;  1Y1N A;  5CDV A;  2GG2 A;  2EVO A;  1QXW A;  4HXX A;  3TAV A;  2EA4 A;  2NQ6 A;  1C24 A;  3MX6 A;  1MAT A;  1W2M A;  4IU6 A;  4ZWP A;  4ZWU A;  1QZY A;  2GU4 A;  2GG7 A;  1C23 A;  5CDE A;  2GZ5 A;  2V3Z A;  1C22 A;  3CB6 A;  5JFR A;  5CDL A;  1WL9 A;  2GU6 A;  4IKS A;  1YW7 A;  1XGO A;  1O0X A;  4IKR A;  1KQ0 A;  1C27 A;  3MR1 A;  5CLS A;  4U6W A;  5FCH A;  1R5H A;  2Q96 A;  4A6W A;  4Z7M A;  2P9A A;  1N51 A;  2IW2 A;  4S00 A;  4QR8 A;  5D6E A;  2GU5 A;  2BWV A;  1QXZ A;  1PV9 A;  4RZZ A;  4U71 A;  5D6F A;  4IKT A;  2BHC A;  2P98 A;  3CB5 A;  3IG4 A;  3TB5 A;  2GTX A;  4U75 A;  1QXY A;  1BN5 A;  2BHD A;  2ADU A;  2BWU A;  2DFI A;  4U76 A;  2GG9 A;  2EVM A;  3IU8 A;  4OOK A;  1W7V A;  2B3L A;  2V3Y A;  4FLJ A;  2GA2 A;  1R58 A;  3IU7 A;  2BB7 A;  2Q94 A;  4FO7 A;  4EGE A;  1R5G A;  1JAW A;  3Q6D A;  4ZNG A;  3PKC A;  3FM3 A;  4RGZ 1;  5JHU A;  4FO8 A;  2NQ7 A;  4RZY A;  1WL6 A;  2Q8K A;  4U6C A;  1XGM A;  2GGB A;  4B28 A;  1XNZ A;  1B6A A;  4R60 A;  1YW9 A;  5E5B A;  1YW8 A;  2BN7 A;  2GG0 A;  3S6B A;  2B3K A;  4U6Z A;  4ZWO A;  4IF7 A;  2BWT A;  2G6P A;  3FMQ A;  3D27 A;  4S01 A;  4U1B A;  2BWW A;  1WY2 A;  3BIP A;  2V6C A;  3ROR A;  5CE6 A;  1KP0 A;  1YJ3 A;  3L7G A;  2Q92 A;  5CIK A;  3PKD A;  1A16 A;  5CNX A;  1YVM A; 
#chains in the Genus database with same CATH homology
 2V3X A;  2EA2 A;  1WKM A;  3PKB A;  4U6E A;  3L24 A;  3MAT A;  2BH3 A;  2P99 A;  3PKA A;  2ZSG A;  4U73 A;  1WLR A;  2B3H A;  4S2R P;  3BIT A;  2OAZ A;  2HOW A;  4PV4 A;  4KM3 A;  1XGS A;  3CTZ A;  4IPA A;  2OKN A;  3BIQ A;  4MAT A;  1WN1 A;  4U70 A;  1WBQ A;  1B59 A;  2BWY A;  4IEC A;  2GU7 A;  2GG8 A;  2BHA A;  2MAT A;  3FMR A;  1M35 A;  4PNC A;  4U6J A;  2GGC A;  1CHM A;  4FUK A;  4FLK A;  2BWS A;  4FLI A;  4A6V A;  3RVA A;  2BWX A;  2Q93 A;  2BHB A;  4FLL A;  3PKE A;  2EVC A;  5FCF A;  4FKC A;  1XGN A;  4IDY A;  1C21 A;  1BOA A;  2GG5 A;  5JI6 A;  4IKU A;  4U69 A;  3IU9 A;  4S2T P;  1KQ9 A;  2Q95 A;  2GG3 A;  4JUQ A;  1Y1N A;  5CDV A;  2GG2 A;  2EVO A;  1QXW A;  4HXX A;  3TAV A;  2EA4 A;  2NQ6 A;  1C24 A;  3MX6 A;  1MAT A;  1W2M A;  4IU6 A;  4ZWP A;  4ZWU A;  1QZY A;  2GU4 A;  2GG7 A;  1C23 A;  5CDE A;  2GZ5 A;  2V3Z A;  1C22 A;  3CB6 A;  5JFR A;  5CDL A;  1WL9 A;  2GU6 A;  4IKS A;  1YW7 A;  1XGO A;  1O0X A;  4IKR A;  1KQ0 A;  1C27 A;  3MR1 A;  5CLS A;  4U6W A;  5FCH A;  1R5H A;  2Q96 A;  4A6W A;  4Z7M A;  2P9A A;  1N51 A;  2IW2 A;  4S00 A;  4QR8 A;  5D6E A;  2GU5 A;  2BWV A;  1QXZ A;  1PV9 A;  4RZZ A;  4U71 A;  5D6F A;  4IKT A;  2BHC A;  2P98 A;  3CB5 A;  3IG4 A;  3TB5 A;  2GTX A;  4U75 A;  1QXY A;  1BN5 A;  2BHD A;  2ADU A;  2BWU A;  2DFI A;  4U76 A;  2GG9 A;  2EVM A;  3IU8 A;  4OOK A;  1W7V A;  2B3L A;  2V3Y A;  4FLJ A;  2GA2 A;  1R58 A;  3IU7 A;  2BB7 A;  2Q94 A;  4FO7 A;  4EGE A;  1R5G A;  1JAW A;  3Q6D A;  4ZNG A;  3PKC A;  3FM3 A;  4RGZ 1;  5JHU A;  4FO8 A;  2NQ7 A;  4RZY A;  1WL6 A;  2Q8K A;  4U6C A;  1XGM A;  2GGB A;  4B28 A;  1XNZ A;  1B6A A;  4R60 A;  1YW9 A;  5E5B A;  1YW8 A;  2BN7 A;  2GG0 A;  3S6B A;  2B3K A;  4U6Z A;  4ZWO A;  4IF7 A;  2BWT A;  2G6P A;  3FMQ A;  3D27 A;  4S01 A;  4U1B A;  2BWW A;  1WY2 A;  3BIP A;  2V6C A;  3ROR A;  5CE6 A;  1KP0 A;  1YJ3 A;  3L7G A;  2Q92 A;  5CIK A;  3PKD A;  1A16 A;  5CNX A;  1YVM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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