1R1HA

Structural analysis of neprilysin with various specific and potent inhibitors
Total Genus 272
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
272
sequence length
696
structure length
696
Chain Sequence
GICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural analysis of neprilysin with various specific and potent inhibitors.
pubmed doi rcsb
molecule keywords Neprilysin
molecule tags Hydrolase
source organism Homo sapiens
total genus 272
structure length 696
sequence length 696
ec nomenclature ec 3.4.24.11: Neprilysin.
pdb deposition date 2003-09-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01431 Peptidase_M13 Peptidase family M13
A PF05649 Peptidase_M13_N Peptidase family M13
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1380.10 Mainly Alpha Orthogonal Bundle Neutral endopeptidase; domain 2 Neutral endopeptidase , domain2 1r1hA02
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 1r1hA01
4H82A 4WF6A 4A3WA 4WKEA 4H49A 1S4BP 4IJOA 1QUAA 4H30A 2JNPA 1SATA 3WV3A 1R1HA 1GE7A 3AYKA 4L63A 1EUBA 1MMQA 1XURA 2POJA 1R1IA 4XM8A 830CA 2K2GA 1IAAA 3L0VA 1I73A 1QIBA 3DSLA 4GF1A 5I3MA 4L19A 1C8TA 2E3XA 3KECA 3HDBA 4GR8A 3HB2P 5CXAA 1Y8JA 1XFXA 5L7FA 2OXZA 1HFCA 2D1NA 5JMYA 4CTHA 1RMZA 1CIZA 2EROA 3EDIA 1ASTA 3HBUP 5I12A 1R55A 3HDAP 3LMCA 4IUWA 1G4KA 2K9CA 1AYKA 2OZRA 3LQBA 1CK7A 2OW2A 3N2UA 1DTHA 4WK7A 3HYGA 1HY7A 1ZXVA 2N8RA 1XFWA 1OMJA 5I43A 3SHIA 2MLSA 1GKCA 2OVZA 1HTDA 1USNA 1ATLA 3HBVP 2HU6A 2AIGP 3B2ZA 3AYUA 1JANA 4XM6A 3WV2A 5LABA 1JIWP 1MNCA 1PWWA 4PKUA 1GO7P 1G9KA 1BUVM 1JKYA 1FBLA 3GBOA 1EAKA 4DPEA 2JT6A 1BKCI 1QJJA 1MMRA 3ZUKA 3L0TA 2ERQA 3HY9A 1RM8A 1MMBA 3G5CA 1XFVA 2J83A 1OM8A 4EFSA 1BQQM 2X7MA 5L79A 2DW1A 3UVCA 2SRTA 4QKZA 3TS4A 1BM6A 1ZP5A 2OI0A 5BPAA 4GUYA 1SRPA 2Z2DA 2ERPA 1PWPA 1UTTA 4I03A 1SLNA 4JQGA 4JA1A 1JAQA 2AYKA 3U1RA 3DNGA 2MZEA 1Y93A 3KMCA 2QPJA 1YCMA 1XFYA 3LUNA 3LJZA 1CGEA 4FXQA 4R3VA 1K7QA 1GXDA 2PJTA 4XM7A 2W12A 2FV5A 2V4BA 3Q2GA 2WO9A 1OM6A 1HFSA 1OS9A 2WO8A 2CKIA 2OXWA 3LQ0A 1IABA 2JT5A 2XS4A 3NX7A 4DF9A 2O36A 1AKLA 1GE6A 4G9LA 1WNIA 1DMTA 2USNA 3K7LA 5D1SA 4JP4A 3LIKA 1JH1A 1BUDA 2Y6CA 1ZVXA 1KUIA 1D5JA 1D8MA 1UMTA 2KRJA 2OW1A 4GWNA 3EHYA 4WZVA 4PKRA 2OY4A 4FXYP 4JPAA 3WV1A 5D1TA 1G12A 1CQRA 2RJPA 2W14A 3TVCA 4H84A 3LK8A 1GO8P 1XUCA 4DD8A 1FLSA 3AIGA 1J7NA 3MA2A 3K7NA 3BA0A 1A85A 3F18A 4FVLA 3LEAA 1MMPA 1QICA 3VI1A 4H76A 1A86A 1YQYA 4FU4A 1H71P 3N2VA 4ILWD 1IAEA 2L0RA 3USNA 4H3XA 5CZMA 1FM1A 1Z3JA 2WOAA 1K7IA 1YOUA 1XFZA 3KHIA 4HX3A 3VTGA 1D8FA 5I4OA 3B92A 1JAOA 1KUHA 2OW9A 4A7BA 1KUGA 4PKVA 1B3DA 3OHLA 4J4MA 4L6TA 3LJGA 1GE5A 1Q3AA 1UEAA 1JK3A 1ND1A 3CKIA 3LE9A 1R1JA 3V96B 3KRYA 1ZS0A 1JIZA 1KAPP 1BKCE 3F19A 5D7WA 1C7KA 1QIAA 1BZSA 4H1QA 1I76A 3EDGA 4PKWA 3LJTA 1IAGA 1JJ9A 3RTTA 456CA 4ON1A 3OHOA 4AYKA 1L6JA 1I1IP 1ROSA 4WKIA 1ZTQA 1BKCA 4ZR5A 3HY7A 3KMEA 2OVXA 3B8ZA 2X3BA 1BSWA 2O3EA 2OXUA 4G0DA 1UMSA 1PWUA 1YP1A 3KEJA 1R54A 1KUFA 1IADA 3LGPA 1KBCA 3EWJA 4Q1LA 3F17A 3F16A 1JAPA 2J0TA 2D1OA 2FV9A 3DPEA 2W15A 3P24A 2Y6DA 4DV8A 3LKAA 4HMAA 3LUMA 1OM7A 1O0QA 1D7XA 4GR0A 2MZHA 5D2BA 1Y0VA 1BQOA 2JIHA 3EDZA 1CXVA 1OS2A 1K7GA 2RJQA 1KUKA 3DPFA 966CA 1CGFA 2YIGA 4XCTA 2DW0A 1G49A 4AUOA 1B8YA 1XFUA 2DW2A 2DDFA 4GQLA 2MZIA 3O64A 4PKSA 4PKQA 2I47A 3I7IA 4I35A 1BIWA 1PWVA 2TCLA 3ZVSA 1C3IA 5CUHA 3EHXA 1QJIA 2X3AA 1XUDA 5D1UA 1SMPA 4AIGA 5I0LA 3P1VA 1OO9A 3ZXHA 3DL1A 5I2ZA 2A8HA 2OY2A 1CGLA 3EDHA 4XBHA 2OW0A 3Q2HA 4PKTA 2W13A 3TT4A 3O2XA 3TSKA 3E8RA 1PWQA 2XS3A 5B5OA 3RTSA 4AXQA 3DWBA 3KWVC 3G42A 2CLTA 1SLMA 2MLRA 1SU3A 3LILA 4GR3A 1EB6A 3F1AA 2YB9A 1G05A 5D3CA 4H2EA 4IN9A 4JIJA 5BOTA 3F15A 3LIRA 1UTZA 2E2DA 3KEKA 2X3CA 5BOYA 1GKDA 1IACA 2JSDA 5H8XA 5B5PA 1AF0A 3ELMA 4GWMA 1HV5A 1O0TA 3I7GA 1HOVA 2W0DA 2DDYA 1CAQA 1ZXCA
chains in the Genus database with same CATH superfamily
4H82A 4WF6A 4A3WA 1OZ9A 4WKEA 4H49A 1XM5A 1S4BP 4IJOA 1QUAA 4H30A 3DTIA 2JNPA 1SATA 3WV3A 1R1HA 1GE7A 3AYKA 4L63A 1EUBA 1MMQA 1XURA 2POJA 1R1IA 4XM8A 830CA 2K2GA 1IAAA 3L0VA 1I73A 1QIBA 3DSLA 4GF1A 5I3MA 4L19A 1C8TA 2E3XA 3KECA 3HDBA 4GR8A 3HB2P 5CXAA 1Y8JA 1XFXA 5L7FA 2OXZA 1HFCA 2D1NA 5JMYA 4CTHA 1RMZA 1CIZA 2EROA 3EDIA 1ASTA 3HBUP 5I12A 1R55A 3HDAP 3LMCA 4IUWA 1G4KA 2K9CA 1AYKA 2OZRA 3LQBA 1CK7A 2OW2A 2YUFA 3N2UA 1DTHA 4WK7A 3HYGA 1HY7A 1ZXVA 2N8RA 1XFWA 1OMJA 5I43A 4L7AA 3SHIA 2MLSA 1GKCA 2OVZA 1HTDA 1USNA 1ATLA 3HBVP 2HU6A 2AIGP 3B2ZA 3AYUA 1JANA 4XM6A 3WV2A 5LABA 1JIWP 1MNCA 1PWWA 4PKUA 1GO7P 1G9KA 1BUVM 1JKYA 1FBLA 3GBOA 1EAKA 4DPEA 2JT6A 1BKCI 3DTEA 1QJJA 1MMRA 3ZUKA 3L0TA 2ERQA 3HY9A 1RM8A 1MMBA 3G5CA 1XFVA 2J83A 1OM8A 4EFSA 1BQQM 2X7MA 5L79A 2DW1A 3UVCA 2SRTA 4QKZA 3TS4A 1BM6A 1ZP5A 2OI0A 5BPAA 4GUYA 1SRPA 2Z2DA 2ERPA 1PWPA 1UTTA 4I03A 1SLNA 4JQGA 4JA1A 1JAQA 2AYKA 3U1RA 3DNGA 2MZEA 1Y93A 3KMCA 2QPJA 1YCMA 1XFYA 3LUNA 3LJZA 1CGEA 4FXQA 4R3VA 1K7QA 1GXDA 2PJTA 4XM7A 2W12A 2FV5A 2V4BA 3Q2GA 2WO9A 1OM6A 1HFSA 1OS9A 2WO8A 2CKIA 2OXWA 3LQ0A 1IABA 2JT5A 2XS4A 3NX7A 4DF9A 2O36A 1AKLA 1GE6A 4G9LA 1WNIA 1XAXA 1DMTA 2USNA 3K7LA 5D1SA 4JP4A 3LIKA 1JH1A 1BUDA 2Y6CA 1ZVXA 1KUIA 1D5JA 1D8MA 1UMTA 2KRJA 2OW1A 4GWNA 3EHYA 4WZVA 4PKRA 2OY4A 4FXYP 4JPAA 3WV1A 5D1TA 1G12A 1CQRA 2RJPA 2W14A 3TVCA 4H84A 3LK8A 1GO8P 1XUCA 4DD8A 1FLSA 3AIGA 1J7NA 3MA2A 3K7NA 3BA0A 1A85A 3F18A 4FVLA 3LEAA 1MMPA 1QICA 3VI1A 4H76A 1A86A 1YQYA 4FU4A 1H71P 3N2VA 4ILWD 1IAEA 2L0RA 3USNA 4H3XA 5CZMA 1FM1A 1Z3JA 2WOAA 1K7IA 1YOUA 1XFZA 3KHIA 4HX3A 3VTGA 1D8FA 5I4OA 3B92A 1JAOA 1KUHA 2OW9A 4A7BA 1KUGA 4PKVA 1B3DA 3OHLA 4J4MA 4L6TA 3LJGA 1GE5A 1Q3AA 1UEAA 1JK3A 1ND1A 3CKIA 3LE9A 1TVIA 1R1JA 3V96B 3KRYA 1ZS0A 1JIZA 1KAPP 1BKCE 3F19A 5D7WA 1C7KA 1QIAA 1BZSA 4H1QA 1I76A 3EDGA 4PKWA 3LJTA 1IAGA 1JJ9A 3RTTA 456CA 4ON1A 3OHOA 4AYKA 1L6JA 1I1IP 1ROSA 4WKIA 1ZTQA 1BKCA 4ZR5A 3HY7A 3KMEA 2OVXA 3B8ZA 2X3BA 1BSWA 2O3EA 2OXUA 4G0DA 1UMSA 1PWUA 1YP1A 3KEJA 1R54A 1KUFA 1IADA 3LGPA 1KBCA 3EWJA 4Q1LA 3F17A 3F16A 1JAPA 2J0TA 2D1OA 2FV9A 3DPEA 2W15A 3P24A 2Y6DA 4DV8A 3LKAA 4HMAA 3LUMA 1OM7A 1O0QA 1D7XA 4GR0A 2MZHA 5D2BA 1Y0VA 1BQOA 2JIHA 3EDZA 1CXVA 1OS2A 1K7GA 2RJQA 1KUKA 3DPFA 966CA 1CGFA 2YIGA 4XCTA 2DW0A 1G49A 4AUOA 1B8YA 1XFUA 2DW2A 2DDFA 4GQLA 2MZIA 3O64A 4PKSA 4PKQA 2I47A 3I7IA 4I35A 1BIWA 1PWVA 2TCLA 3ZVSA 1C3IA 5CUHA 3EHXA 1QJIA 2X3AA 1XUDA 5D1UA 1SMPA 4AIGA 5I0LA 3P1VA 1OO9A 3ZXHA 3DL1A 5I2ZA 2A8HA 2OY2A 1CGLA 3EDHA 4XBHA 2OW0A 3Q2HA 4PKTA 3DTKA 2W13A 3TT4A 3O2XA 3TSKA 3E8RA 1PWQA 2XS3A 5B5OA 3RTSA 4AXQA 3DWBA 3KWVC 3G42A 2CLTA 1SLMA 2MLRA 1SU3A 3LILA 4GR3A 1EB6A 3F1AA 2YB9A 1G05A 5D3CA 4H2EA 4IN9A 4JIJA 5BOTA 3F15A 3LIRA 1UTZA 2E2DA 3KEKA 2X3CA 5BOYA 1GKDA 1IACA 2JSDA 5H8XA 5B5PA 1AF0A 3ELMA 4GWMA 1HV5A 1O0TA 3I7GA 1HOVA 2W0DA 2DDYA 1CAQA 1ZXCA
chains in the Genus database with same CATH topology
4H82A 4WF6A 4A3WA 4WKEA 4H49A 1S4BP 4IJOA 1QUAA 4H30A 3DTIA 2JNPA 1SATA 3WV3A 1R1HA 1GE7A 3AYKA 4L63A 1EUBA 1MMQA 1XURA 2POJA 1R1IA 4XM8A 830CA 2K2GA 1IAAA 3L0VA 1I73A 1QIBA 3DSLA 4GF1A 5I3MA 4L19A 1C8TA 2E3XA 3KECA 3HDBA 4GR8A 3HB2P 5CXAA 1Y8JA 1XFXA 5L7FA 2OXZA 1HFCA 2D1NA 5JMYA 4CTHA 1RMZA 1CIZA 2EROA 3EDIA 1ASTA 3HBUP 5I12A 1R55A 3HDAP 3LMCA 4IUWA 1G4KA 2K9CA 1AYKA 2OZRA 3LQBA 1CK7A 2OW2A 2YUFA 3N2UA 1DTHA 4WK7A 3HYGA 1HY7A 1ZXVA 2N8RA 1XFWA 1OMJA 5I43A 4L7AA 3SHIA 2MLSA 1GKCA 2OVZA 1HTDA 1USNA 1ATLA 3HBVP 2HU6A 2AIGP 3B2ZA 3AYUA 1JANA 4XM6A 3WV2A 5LABA 1JIWP 1MNCA 1PWWA 4PKUA 1GO7P 1G9KA 1BUVM 1JKYA 1FBLA 3GBOA 1EAKA 4DPEA 2JT6A 1BKCI 3DTEA 1QJJA 1MMRA 3ZUKA 3L0TA 2ERQA 3HY9A 1RM8A 1MMBA 3G5CA 1XFVA 2J83A 1OM8A 4EFSA 1BQQM 2X7MA 5L79A 2DW1A 3UVCA 2SRTA 4QKZA 3TS4A 1BM6A 1ZP5A 2OI0A 5BPAA 4GUYA 1SRPA 2Z2DA 2ERPA 1PWPA 1UTTA 4I03A 1SLNA 4JQGA 4JA1A 1JAQA 2AYKA 3U1RA 3DNGA 2MZEA 1Y93A 3KMCA 2QPJA 1YCMA 1XFYA 3LUNA 3LJZA 1CGEA 4FXQA 4R3VA 1K7QA 1GXDA 2PJTA 4XM7A 2W12A 2FV5A 2V4BA 3Q2GA 2WO9A 1OM6A 1HFSA 1OS9A 2WO8A 2CKIA 2OXWA 3LQ0A 1IABA 2JT5A 2XS4A 3NX7A 4DF9A 2O36A 1AKLA 1GE6A 4G9LA 1WNIA 1DMTA 2USNA 3K7LA 5D1SA 4JP4A 3LIKA 1JH1A 1BUDA 2Y6CA 1ZVXA 1KUIA 1D5JA 1D8MA 1UMTA 2KRJA 2OW1A 4GWNA 3EHYA 4WZVA 4PKRA 2OY4A 4FXYP 4JPAA 3WV1A 5D1TA 1G12A 1CQRA 2RJPA 2W14A 3TVCA 4H84A 3LK8A 1GO8P 1XUCA 4DD8A 1FLSA 3AIGA 1J7NA 3MA2A 3K7NA 3BA0A 1A85A 3F18A 4FVLA 3LEAA 1MMPA 1QICA 3VI1A 4H76A 1A86A 1YQYA 4FU4A 1H71P 3N2VA 4ILWD 1IAEA 2L0RA 3USNA 4H3XA 5CZMA 1FM1A 1Z3JA 2WOAA 1K7IA 1YOUA 1XFZA 3KHIA 4HX3A 3VTGA 1D8FA 5I4OA 3B92A 1JAOA 1KUHA 2OW9A 4A7BA 1KUGA 4PKVA 1B3DA 3OHLA 4J4MA 4L6TA 3LJGA 1GE5A 1Q3AA 1UEAA 1JK3A 1ND1A 3CKIA 3LE9A 1R1JA 3V96B 3KRYA 1ZS0A 1JIZA 1KAPP 1BKCE 3F19A 5D7WA 1C7KA 1QIAA 1BZSA 4H1QA 1I76A 3EDGA 4PKWA 3LJTA 1IAGA 1JJ9A 3RTTA 456CA 4ON1A 3OHOA 4AYKA 1L6JA 1I1IP 1ROSA 4WKIA 1ZTQA 1BKCA 4ZR5A 3HY7A 3KMEA 2OVXA 3B8ZA 2X3BA 1BSWA 2O3EA 2OXUA 4G0DA 1UMSA 1PWUA 1YP1A 3KEJA 1R54A 1KUFA 1IADA 3LGPA 1KBCA 3EWJA 4Q1LA 3F17A 3F16A 1JAPA 2J0TA 2D1OA 2FV9A 3DPEA 2W15A 3P24A 2Y6DA 4DV8A 3LKAA 4HMAA 3LUMA 1OM7A 1O0QA 1D7XA 4GR0A 2MZHA 5D2BA 1Y0VA 1BQOA 2JIHA 3EDZA 1CXVA 1OS2A 1K7GA 2RJQA 1KUKA 3DPFA 966CA 1CGFA 2YIGA 4XCTA 2DW0A 1G49A 4AUOA 1B8YA 1XFUA 2DW2A 2DDFA 4GQLA 2MZIA 3O64A 4PKSA 4PKQA 2I47A 3I7IA 4I35A 1BIWA 1PWVA 2TCLA 3ZVSA 1C3IA 5CUHA 3EHXA 1QJIA 2X3AA 1XUDA 5D1UA 1SMPA 4AIGA 5I0LA 3P1VA 1OO9A 3ZXHA 3DL1A 5I2ZA 2A8HA 2OY2A 1CGLA 3EDHA 4XBHA 2OW0A 3Q2HA 4PKTA 3DTKA 2W13A 3TT4A 3O2XA 3TSKA 3E8RA 1PWQA 2XS3A 5B5OA 3RTSA 4AXQA 3DWBA 3KWVC 3G42A 2CLTA 1SLMA 2MLRA 1SU3A 3LILA 4GR3A 1EB6A 3F1AA 2YB9A 1G05A 5D3CA 4H2EA 4IN9A 4JIJA 5BOTA 3F15A 3LIRA 1UTZA 2E2DA 3KEKA 2X3CA 5BOYA 1GKDA 1IACA 2JSDA 5H8XA 5B5PA 1AF0A 3ELMA 4GWMA 1HV5A 1O0TA 3I7GA 1HOVA 2W0DA 2DDYA 1CAQA 1ZXCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4H82 A;  4WF6 A;  4A3W A;  4WKE A;  4H49 A;  1S4B P;  4IJO A;  1QUA A;  4H30 A;  2JNP A;  1SAT A;  3WV3 A;  1R1H A;  1GE7 A;  3AYK A;  4L63 A;  1EUB A;  1MMQ A;  1XUR A;  2POJ A;  1R1I A;  4XM8 A;  830C A;  2K2G A;  1IAA A;  3L0V A;  1I73 A;  1QIB A;  3DSL A;  4GF1 A;  5I3M A;  4L19 A;  1C8T A;  2E3X A;  3KEC A;  3HDB A;  4GR8 A;  3HB2 P;  5CXA A;  1Y8J A;  1XFX A;  5L7F A;  2OXZ A;  1HFC A;  2D1N A;  5JMY A;  4CTH A;  1RMZ A;  1CIZ A;  2ERO A;  3EDI A;  1AST A;  3HBU P;  5I12 A;  1R55 A;  3HDA P;  3LMC A;  4IUW A;  1G4K A;  2K9C A;  1AYK A;  2OZR A;  3LQB A;  1CK7 A;  2OW2 A;  3N2U A;  1DTH A;  4WK7 A;  3HYG A;  1HY7 A;  1ZXV A;  2N8R A;  1XFW A;  1OMJ A;  5I43 A;  3SHI A;  2MLS A;  1GKC A;  2OVZ A;  1HTD A;  1USN A;  1ATL A;  3HBV P;  2HU6 A;  2AIG P;  3B2Z A;  3AYU A;  1JAN A;  4XM6 A;  3WV2 A;  5LAB A;  1JIW P;  1MNC A;  1PWW A;  4PKU A;  1GO7 P;  1G9K A;  1BUV M;  1JKY A;  1FBL A;  3GBO A;  1EAK A;  4DPE A;  2JT6 A;  1BKC I;  1QJJ A;  1MMR A;  3ZUK A;  3L0T A;  2ERQ A;  3HY9 A;  1RM8 A;  1MMB A;  3G5C A;  1XFV A;  2J83 A;  1OM8 A;  4EFS A;  1BQQ M;  2X7M A;  5L79 A;  2DW1 A;  3UVC A;  2SRT A;  4QKZ A;  3TS4 A;  1BM6 A;  1ZP5 A;  2OI0 A;  5BPA A;  4GUY A;  1SRP A;  2Z2D A;  2ERP A;  1PWP A;  1UTT A;  4I03 A;  1SLN A;  4JQG A;  4JA1 A;  1JAQ A;  2AYK A;  3U1R A;  3DNG A;  2MZE A;  1Y93 A;  3KMC A;  2QPJ A;  1YCM A;  1XFY A;  3LUN A;  3LJZ A;  1CGE A;  4FXQ A;  4R3V A;  1K7Q A;  1GXD A;  2PJT A;  4XM7 A;  2W12 A;  2FV5 A;  2V4B A;  3Q2G A;  2WO9 A;  1OM6 A;  1HFS A;  1OS9 A;  2WO8 A;  2CKI A;  2OXW A;  3LQ0 A;  1IAB A;  2JT5 A;  2XS4 A;  3NX7 A;  4DF9 A;  2O36 A;  1AKL A;  1GE6 A;  4G9L A;  1WNI A;  1DMT A;  2USN A;  3K7L A;  5D1S A;  4JP4 A;  3LIK A;  1JH1 A;  1BUD A;  2Y6C A;  1ZVX A;  1KUI A;  1D5J A;  1D8M A;  1UMT A;  2KRJ A;  2OW1 A;  4GWN A;  3EHY A;  4WZV A;  4PKR A;  2OY4 A;  4FXY P;  4JPA A;  3WV1 A;  5D1T A;  1G12 A;  1CQR A;  2RJP A;  2W14 A;  3TVC A;  4H84 A;  3LK8 A;  1GO8 P;  1XUC A;  4DD8 A;  1FLS A;  3AIG A;  1J7N A;  3MA2 A;  3K7N A;  3BA0 A;  1A85 A;  3F18 A;  4FVL A;  3LEA A;  1MMP A;  1QIC A;  3VI1 A;  4H76 A;  1A86 A;  1YQY A;  4FU4 A;  1H71 P;  3N2V A;  4ILW D;  1IAE A;  2L0R A;  3USN A;  4H3X A;  5CZM A;  1FM1 A;  1Z3J A;  2WOA A;  1K7I A;  1YOU A;  1XFZ A;  3KHI A;  4HX3 A;  3VTG A;  1D8F A;  5I4O A;  3B92 A;  1JAO A;  1KUH A;  2OW9 A;  4A7B A;  1KUG A;  4PKV A;  1B3D A;  3OHL A;  4J4M A;  4L6T A;  3LJG A;  1GE5 A;  1Q3A A;  1UEA A;  1JK3 A;  1ND1 A;  3CKI A;  3LE9 A;  1R1J A;  3V96 B;  3KRY A;  1ZS0 A;  1JIZ A;  1KAP P;  1BKC E;  3F19 A;  5D7W A;  1C7K A;  1QIA A;  1BZS A;  4H1Q A;  1I76 A;  3EDG A;  4PKW A;  3LJT A;  1IAG A;  1JJ9 A;  3RTT A;  456C A;  4ON1 A;  3OHO A;  4AYK A;  1L6J A;  1I1I P;  1ROS A;  4WKI A;  1ZTQ A;  1BKC A;  4ZR5 A;  3HY7 A;  3KME A;  2OVX A;  3B8Z A;  2X3B A;  1BSW A;  2O3E A;  2OXU A;  4G0D A;  1UMS A;  1PWU A;  1YP1 A;  3KEJ A;  1R54 A;  1KUF A;  1IAD A;  3LGP A;  1KBC A;  3EWJ A;  4Q1L A;  3F17 A;  3F16 A;  1JAP A;  2J0T A;  2D1O A;  2FV9 A;  3DPE A;  2W15 A;  3P24 A;  2Y6D A;  4DV8 A;  3LKA A;  4HMA A;  3LUM A;  1OM7 A;  1O0Q A;  1D7X A;  4GR0 A;  2MZH A;  5D2B A;  1Y0V A;  1BQO A;  2JIH A;  3EDZ A;  1CXV A;  1OS2 A;  1K7G A;  2RJQ A;  1KUK A;  3DPF A;  966C A;  1CGF A;  2YIG A;  4XCT A;  2DW0 A;  1G49 A;  4AUO A;  1B8Y A;  1XFU A;  2DW2 A;  2DDF A;  4GQL A;  2MZI A;  3O64 A;  4PKS A;  4PKQ A;  2I47 A;  3I7I A;  4I35 A;  1BIW A;  1PWV A;  2TCL A;  3ZVS A;  1C3I A;  5CUH A;  3EHX A;  1QJI A;  2X3A A;  1XUD A;  5D1U A;  1SMP A;  4AIG A;  5I0L A;  3P1V A;  1OO9 A;  3ZXH A;  3DL1 A;  5I2Z A;  2A8H A;  2OY2 A;  1CGL A;  3EDH A;  4XBH A;  2OW0 A;  3Q2H A;  4PKT A;  2W13 A;  3TT4 A;  3O2X A;  3TSK A;  3E8R A;  1PWQ A;  2XS3 A;  5B5O A;  3RTS A;  4AXQ A;  3DWB A;  3KWV C;  3G42 A;  2CLT A;  1SLM A;  2MLR A;  1SU3 A;  3LIL A;  4GR3 A;  1EB6 A;  3F1A A;  2YB9 A;  1G05 A;  5D3C A;  4H2E A;  4IN9 A;  4JIJ A;  5BOT A;  3F15 A;  3LIR A;  1UTZ A;  2E2D A;  3KEK A;  2X3C A;  5BOY A;  1GKD A;  1IAC A;  2JSD A;  5H8X A;  5B5P A;  1AF0 A;  3ELM A;  4GWM A;  1HV5 A;  1O0T A;  3I7G A;  1HOV A;  2W0D A;  2DDY A;  1CAQ A;  1ZXC A; 
#chains in the Genus database with same CATH topology
 4H82 A;  4WF6 A;  4A3W A;  1OZ9 A;  4WKE A;  4H49 A;  1XM5 A;  1S4B P;  4IJO A;  1QUA A;  4H30 A;  3DTI A;  2JNP A;  1SAT A;  3WV3 A;  1R1H A;  1GE7 A;  3AYK A;  4L63 A;  1EUB A;  1MMQ A;  1XUR A;  2POJ A;  1R1I A;  4XM8 A;  830C A;  2K2G A;  1IAA A;  3L0V A;  1I73 A;  1QIB A;  3DSL A;  4GF1 A;  5I3M A;  4L19 A;  1C8T A;  2E3X A;  3KEC A;  3HDB A;  4GR8 A;  3HB2 P;  5CXA A;  1Y8J A;  1XFX A;  5L7F A;  2OXZ A;  1HFC A;  2D1N A;  5JMY A;  4CTH A;  1RMZ A;  1CIZ A;  2ERO A;  3EDI A;  1AST A;  3HBU P;  5I12 A;  1R55 A;  3HDA P;  3LMC A;  4IUW A;  1G4K A;  2K9C A;  1AYK A;  2OZR A;  3LQB A;  1CK7 A;  2OW2 A;  2YUF A;  3N2U A;  1DTH A;  4WK7 A;  3HYG A;  1HY7 A;  1ZXV A;  2N8R A;  1XFW A;  1OMJ A;  5I43 A;  4L7A A;  3SHI A;  2MLS A;  1GKC A;  2OVZ A;  1HTD A;  1USN A;  1ATL A;  3HBV P;  2HU6 A;  2AIG P;  3B2Z A;  3AYU A;  1JAN A;  4XM6 A;  3WV2 A;  5LAB A;  1JIW P;  1MNC A;  1PWW A;  4PKU A;  1GO7 P;  1G9K A;  1BUV M;  1JKY A;  1FBL A;  3GBO A;  1EAK A;  4DPE A;  2JT6 A;  1BKC I;  3DTE A;  1QJJ A;  1MMR A;  3ZUK A;  3L0T A;  2ERQ A;  3HY9 A;  1RM8 A;  1MMB A;  3G5C A;  1XFV A;  2J83 A;  1OM8 A;  4EFS A;  1BQQ M;  2X7M A;  5L79 A;  2DW1 A;  3UVC A;  2SRT A;  4QKZ A;  3TS4 A;  1BM6 A;  1ZP5 A;  2OI0 A;  5BPA A;  4GUY A;  1SRP A;  2Z2D A;  2ERP A;  1PWP A;  1UTT A;  4I03 A;  1SLN A;  4JQG A;  4JA1 A;  1JAQ A;  2AYK A;  3U1R A;  3DNG A;  2MZE A;  1Y93 A;  3KMC A;  2QPJ A;  1YCM A;  1XFY A;  3LUN A;  3LJZ A;  1CGE A;  4FXQ A;  4R3V A;  1K7Q A;  1GXD A;  2PJT A;  4XM7 A;  2W12 A;  2FV5 A;  2V4B A;  3Q2G A;  2WO9 A;  1OM6 A;  1HFS A;  1OS9 A;  2WO8 A;  2CKI A;  2OXW A;  3LQ0 A;  1IAB A;  2JT5 A;  2XS4 A;  3NX7 A;  4DF9 A;  2O36 A;  1AKL A;  1GE6 A;  4G9L A;  1WNI A;  1XAX A;  1DMT A;  2USN A;  3K7L A;  5D1S A;  4JP4 A;  3LIK A;  1JH1 A;  1BUD A;  2Y6C A;  1ZVX A;  1KUI A;  1D5J A;  1D8M A;  1UMT A;  2KRJ A;  2OW1 A;  4GWN A;  3EHY A;  4WZV A;  4PKR A;  2OY4 A;  4FXY P;  4JPA A;  3WV1 A;  5D1T A;  1G12 A;  1CQR A;  2RJP A;  2W14 A;  3TVC A;  4H84 A;  3LK8 A;  1GO8 P;  1XUC A;  4DD8 A;  1FLS A;  3AIG A;  1J7N A;  3MA2 A;  3K7N A;  3BA0 A;  1A85 A;  3F18 A;  4FVL A;  3LEA A;  1MMP A;  1QIC A;  3VI1 A;  4H76 A;  1A86 A;  1YQY A;  4FU4 A;  1H71 P;  3N2V A;  4ILW D;  1IAE A;  2L0R A;  3USN A;  4H3X A;  5CZM A;  1FM1 A;  1Z3J A;  2WOA A;  1K7I A;  1YOU A;  1XFZ A;  3KHI A;  4HX3 A;  3VTG A;  1D8F A;  5I4O A;  3B92 A;  1JAO A;  1KUH A;  2OW9 A;  4A7B A;  1KUG A;  4PKV A;  1B3D A;  3OHL A;  4J4M A;  4L6T A;  3LJG A;  1GE5 A;  1Q3A A;  1UEA A;  1JK3 A;  1ND1 A;  3CKI A;  3LE9 A;  1TVI A;  1R1J A;  3V96 B;  3KRY A;  1ZS0 A;  1JIZ A;  1KAP P;  1BKC E;  3F19 A;  5D7W A;  1C7K A;  1QIA A;  1BZS A;  4H1Q A;  1I76 A;  3EDG A;  4PKW A;  3LJT A;  1IAG A;  1JJ9 A;  3RTT A;  456C A;  4ON1 A;  3OHO A;  4AYK A;  1L6J A;  1I1I P;  1ROS A;  4WKI A;  1ZTQ A;  1BKC A;  4ZR5 A;  3HY7 A;  3KME A;  2OVX A;  3B8Z A;  2X3B A;  1BSW A;  2O3E A;  2OXU A;  4G0D A;  1UMS A;  1PWU A;  1YP1 A;  3KEJ A;  1R54 A;  1KUF A;  1IAD A;  3LGP A;  1KBC A;  3EWJ A;  4Q1L A;  3F17 A;  3F16 A;  1JAP A;  2J0T A;  2D1O A;  2FV9 A;  3DPE A;  2W15 A;  3P24 A;  2Y6D A;  4DV8 A;  3LKA A;  4HMA A;  3LUM A;  1OM7 A;  1O0Q A;  1D7X A;  4GR0 A;  2MZH A;  5D2B A;  1Y0V A;  1BQO A;  2JIH A;  3EDZ A;  1CXV A;  1OS2 A;  1K7G A;  2RJQ A;  1KUK A;  3DPF A;  966C A;  1CGF A;  2YIG A;  4XCT A;  2DW0 A;  1G49 A;  4AUO A;  1B8Y A;  1XFU A;  2DW2 A;  2DDF A;  4GQL A;  2MZI A;  3O64 A;  4PKS A;  4PKQ A;  2I47 A;  3I7I A;  4I35 A;  1BIW A;  1PWV A;  2TCL A;  3ZVS A;  1C3I A;  5CUH A;  3EHX A;  1QJI A;  2X3A A;  1XUD A;  5D1U A;  1SMP A;  4AIG A;  5I0L A;  3P1V A;  1OO9 A;  3ZXH A;  3DL1 A;  5I2Z A;  2A8H A;  2OY2 A;  1CGL A;  3EDH A;  4XBH A;  2OW0 A;  3Q2H A;  4PKT A;  3DTK A;  2W13 A;  3TT4 A;  3O2X A;  3TSK A;  3E8R A;  1PWQ A;  2XS3 A;  5B5O A;  3RTS A;  4AXQ A;  3DWB A;  3KWV C;  3G42 A;  2CLT A;  1SLM A;  2MLR A;  1SU3 A;  3LIL A;  4GR3 A;  1EB6 A;  3F1A A;  2YB9 A;  1G05 A;  5D3C A;  4H2E A;  4IN9 A;  4JIJ A;  5BOT A;  3F15 A;  3LIR A;  1UTZ A;  2E2D A;  3KEK A;  2X3C A;  5BOY A;  1GKD A;  1IAC A;  2JSD A;  5H8X A;  5B5P A;  1AF0 A;  3ELM A;  4GWM A;  1HV5 A;  1O0T A;  3I7G A;  1HOV A;  2W0D A;  2DDY A;  1CAQ A;  1ZXC A; 
#chains in the Genus database with same CATH homology
 4H82 A;  4WF6 A;  4A3W A;  4WKE A;  4H49 A;  1S4B P;  4IJO A;  1QUA A;  4H30 A;  3DTI A;  2JNP A;  1SAT A;  3WV3 A;  1R1H A;  1GE7 A;  3AYK A;  4L63 A;  1EUB A;  1MMQ A;  1XUR A;  2POJ A;  1R1I A;  4XM8 A;  830C A;  2K2G A;  1IAA A;  3L0V A;  1I73 A;  1QIB A;  3DSL A;  4GF1 A;  5I3M A;  4L19 A;  1C8T A;  2E3X A;  3KEC A;  3HDB A;  4GR8 A;  3HB2 P;  5CXA A;  1Y8J A;  1XFX A;  5L7F A;  2OXZ A;  1HFC A;  2D1N A;  5JMY A;  4CTH A;  1RMZ A;  1CIZ A;  2ERO A;  3EDI A;  1AST A;  3HBU P;  5I12 A;  1R55 A;  3HDA P;  3LMC A;  4IUW A;  1G4K A;  2K9C A;  1AYK A;  2OZR A;  3LQB A;  1CK7 A;  2OW2 A;  2YUF A;  3N2U A;  1DTH A;  4WK7 A;  3HYG A;  1HY7 A;  1ZXV A;  2N8R A;  1XFW A;  1OMJ A;  5I43 A;  4L7A A;  3SHI A;  2MLS A;  1GKC A;  2OVZ A;  1HTD A;  1USN A;  1ATL A;  3HBV P;  2HU6 A;  2AIG P;  3B2Z A;  3AYU A;  1JAN A;  4XM6 A;  3WV2 A;  5LAB A;  1JIW P;  1MNC A;  1PWW A;  4PKU A;  1GO7 P;  1G9K A;  1BUV M;  1JKY A;  1FBL A;  3GBO A;  1EAK A;  4DPE A;  2JT6 A;  1BKC I;  3DTE A;  1QJJ A;  1MMR A;  3ZUK A;  3L0T A;  2ERQ A;  3HY9 A;  1RM8 A;  1MMB A;  3G5C A;  1XFV A;  2J83 A;  1OM8 A;  4EFS A;  1BQQ M;  2X7M A;  5L79 A;  2DW1 A;  3UVC A;  2SRT A;  4QKZ A;  3TS4 A;  1BM6 A;  1ZP5 A;  2OI0 A;  5BPA A;  4GUY A;  1SRP A;  2Z2D A;  2ERP A;  1PWP A;  1UTT A;  4I03 A;  1SLN A;  4JQG A;  4JA1 A;  1JAQ A;  2AYK A;  3U1R A;  3DNG A;  2MZE A;  1Y93 A;  3KMC A;  2QPJ A;  1YCM A;  1XFY A;  3LUN A;  3LJZ A;  1CGE A;  4FXQ A;  4R3V A;  1K7Q A;  1GXD A;  2PJT A;  4XM7 A;  2W12 A;  2FV5 A;  2V4B A;  3Q2G A;  2WO9 A;  1OM6 A;  1HFS A;  1OS9 A;  2WO8 A;  2CKI A;  2OXW A;  3LQ0 A;  1IAB A;  2JT5 A;  2XS4 A;  3NX7 A;  4DF9 A;  2O36 A;  1AKL A;  1GE6 A;  4G9L A;  1WNI A;  1DMT A;  2USN A;  3K7L A;  5D1S A;  4JP4 A;  3LIK A;  1JH1 A;  1BUD A;  2Y6C A;  1ZVX A;  1KUI A;  1D5J A;  1D8M A;  1UMT A;  2KRJ A;  2OW1 A;  4GWN A;  3EHY A;  4WZV A;  4PKR A;  2OY4 A;  4FXY P;  4JPA A;  3WV1 A;  5D1T A;  1G12 A;  1CQR A;  2RJP A;  2W14 A;  3TVC A;  4H84 A;  3LK8 A;  1GO8 P;  1XUC A;  4DD8 A;  1FLS A;  3AIG A;  1J7N A;  3MA2 A;  3K7N A;  3BA0 A;  1A85 A;  3F18 A;  4FVL A;  3LEA A;  1MMP A;  1QIC A;  3VI1 A;  4H76 A;  1A86 A;  1YQY A;  4FU4 A;  1H71 P;  3N2V A;  4ILW D;  1IAE A;  2L0R A;  3USN A;  4H3X A;  5CZM A;  1FM1 A;  1Z3J A;  2WOA A;  1K7I A;  1YOU A;  1XFZ A;  3KHI A;  4HX3 A;  3VTG A;  1D8F A;  5I4O A;  3B92 A;  1JAO A;  1KUH A;  2OW9 A;  4A7B A;  1KUG A;  4PKV A;  1B3D A;  3OHL A;  4J4M A;  4L6T A;  3LJG A;  1GE5 A;  1Q3A A;  1UEA A;  1JK3 A;  1ND1 A;  3CKI A;  3LE9 A;  1R1J A;  3V96 B;  3KRY A;  1ZS0 A;  1JIZ A;  1KAP P;  1BKC E;  3F19 A;  5D7W A;  1C7K A;  1QIA A;  1BZS A;  4H1Q A;  1I76 A;  3EDG A;  4PKW A;  3LJT A;  1IAG A;  1JJ9 A;  3RTT A;  456C A;  4ON1 A;  3OHO A;  4AYK A;  1L6J A;  1I1I P;  1ROS A;  4WKI A;  1ZTQ A;  1BKC A;  4ZR5 A;  3HY7 A;  3KME A;  2OVX A;  3B8Z A;  2X3B A;  1BSW A;  2O3E A;  2OXU A;  4G0D A;  1UMS A;  1PWU A;  1YP1 A;  3KEJ A;  1R54 A;  1KUF A;  1IAD A;  3LGP A;  1KBC A;  3EWJ A;  4Q1L A;  3F17 A;  3F16 A;  1JAP A;  2J0T A;  2D1O A;  2FV9 A;  3DPE A;  2W15 A;  3P24 A;  2Y6D A;  4DV8 A;  3LKA A;  4HMA A;  3LUM A;  1OM7 A;  1O0Q A;  1D7X A;  4GR0 A;  2MZH A;  5D2B A;  1Y0V A;  1BQO A;  2JIH A;  3EDZ A;  1CXV A;  1OS2 A;  1K7G A;  2RJQ A;  1KUK A;  3DPF A;  966C A;  1CGF A;  2YIG A;  4XCT A;  2DW0 A;  1G49 A;  4AUO A;  1B8Y A;  1XFU A;  2DW2 A;  2DDF A;  4GQL A;  2MZI A;  3O64 A;  4PKS A;  4PKQ A;  2I47 A;  3I7I A;  4I35 A;  1BIW A;  1PWV A;  2TCL A;  3ZVS A;  1C3I A;  5CUH A;  3EHX A;  1QJI A;  2X3A A;  1XUD A;  5D1U A;  1SMP A;  4AIG A;  5I0L A;  3P1V A;  1OO9 A;  3ZXH A;  3DL1 A;  5I2Z A;  2A8H A;  2OY2 A;  1CGL A;  3EDH A;  4XBH A;  2OW0 A;  3Q2H A;  4PKT A;  3DTK A;  2W13 A;  3TT4 A;  3O2X A;  3TSK A;  3E8R A;  1PWQ A;  2XS3 A;  5B5O A;  3RTS A;  4AXQ A;  3DWB A;  3KWV C;  3G42 A;  2CLT A;  1SLM A;  2MLR A;  1SU3 A;  3LIL A;  4GR3 A;  1EB6 A;  3F1A A;  2YB9 A;  1G05 A;  5D3C A;  4H2E A;  4IN9 A;  4JIJ A;  5BOT A;  3F15 A;  3LIR A;  1UTZ A;  2E2D A;  3KEK A;  2X3C A;  5BOY A;  1GKD A;  1IAC A;  2JSD A;  5H8X A;  5B5P A;  1AF0 A;  3ELM A;  4GWM A;  1HV5 A;  1O0T A;  3I7G A;  1HOV A;  2W0D A;  2DDY A;  1CAQ A;  1ZXC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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