1S20A

A novel nad binding protein revealed by the crystal structure of e. coli 2,3-diketogulonate reductase (yiak) northeast structural genomics consortium target er82
Total Genus 98
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
98
sequence length
334
structure length
334
Chain Sequence
MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQALLE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A Novel NAD-binding Protein Revealed by the Crystal Structure of 2,3-Diketo-L-gulonate Reductase (YiaK).
pubmed doi rcsb
source organism Escherichia coli
molecule tags Oxidoreductase
molecule keywords Hypothetical oxidoreductase yiaK
total genus 98
structure length 334
sequence length 334
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 1.1.1.130: 3-dehydro-L-gulonate 2-dehydrogenase.
pdb deposition date 2004-01-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02615 Ldh_2 Malate/L-lactate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1530.10 Mainly Alpha Orthogonal Bundle Hypothetical Oxidoreductase Yiak; Chain: A, domain 1 Hypothetical Oxidoreductase Yiak; Chain: A, domain 1 1s20A01
3.30.60.50 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Hypothetical oxidoreductase yiak; domain 3 1s20A03
3.30.1370.60 Alpha Beta 2-Layer Sandwich Ribosomal Protein S8; Chain: A, domain 1 Hypothetical oxidoreductase yiak; domain 2 1s20A02
2G8YA 1WTJA 1X0AA 1Z2IA 4FJUA 2CWFA 4FJSA 1V9NA 1XRHA 2CWHA 3UOEA 4H8AA 1VBIA 1S20A 2X06A 3I0PA 1NXUA
chains in the Genus database with same CATH superfamily
5E3PA 1BMOA 3KDKA 1PCEA 2P2RA 3KY9A 2JW6A 5JHWC 1ZZJA 2F3CI 1Y8FA 2YUUA 1X4MA 4LF8H 1XBTA 1NXUA 4B3TH 4LFCH 1N32H 3PDNA 1HNXH 2WGCA 3I0PA 4JCVE 4NZRM 1MSZA 2FFMA 1S03G 2UXCH 4OVOA 3JAMW 1TBQR 1WHRA 3E59A 3UEJA 3CXLA 4G08A 2G8YA 1PTQA 1HR0H 2JYYA 5J8CA 4LIJA 2ENZA 2MJHA 1CT2I 1ZTGA 2SGPI 1SGNI 2GIVA 1Y1CA 1S20A 2DB6A 2DIPA 2CTLA 3T1YH 3TOBA 4B8CD 2UXDH 2LB7A 3AEVB 1ZZIA 1BUSA 1P9GA 2SGEI 4JI5H 2JEAI 4DUZH 4K0KH 2JVZA 1Z7KB 1WKXA 4H8AA 2J9RA 1PPFI 1I6UA 3TO9A 2L8EA 1XX6A 2CJSC 2V1CA 2LTLA 4WP4A 4X62H 4UXJA 1UVFA 2QNDA 2VKCA 2E3UA 5E3RA 4AM3A 1XMQH 1NUBA 3SGQI 9WGAA 3FSXA 2SGQI 4B8TA 2FMRA 1RFHA 4LF9H 1N13A 2VRWB 4FKDA 4DV5H 1TIHA 2P6AC 1VIHA 2KMOA 4OX9H 1Q9BA 5J8FA 2OU2A 1J4WA 4JI4H 5FUVA 4NBQA 1LR7A 3TO7A 1TUAA 2W0TA 1R0RI 2ROWA 4DV4H 1WGCA 3VDUA 1MJAA 3QD7X 4JVYA 3UGDA 1ODHA 1SEIA 2O4CA 4DR3H 4DNCA 4JI3H 2E73A 3TO6A 2JA9A 4SGBI 2CTJA 2LEOA 1SGRI 1UVGA 4FJSA 1W4RA 4B3MH 2X06A 1WE8A 1TGSI 2LUYA 1X9ZA 2NU2I 1N34H 4JV5H 4NXMH 3BJIA 1F0XA 4EC5A 4DV7H 5CCMA 2YQRA 1K7TA 2UUBH 2OPVA 1XNQH 1TBNA 2BA0A 4BA1I 3D00A 1PJUA 2BUSA 4UXHA 4JI1H 1OVOA 2X3TA 2QQ0A 2LRRA 2JA1A 5HQ8A 1TURA 2KMRA 2UVOA 2ZQEA 1TUSA 1LR8A 1ULNA 4B3SH 4JI6H 2OZUA 2ENNA 1CT4I 3R5DA 1CGJI 4MPIA 1FJGH 2CWHA 2K1HA 2AXYA 1HNWH 1EC6A 2ORVA 1N33H 4UXIA 5DT9A 3QWPA 5EX0A 2YQPA 3SGBI 2PY9A 1X0AA 2B0UC 4KHPH 1FYBA 1KMAA 3NCVA 4DUYH 2N1AB 3VDPA 2UXBH 2GKVA 2Z0SA 4WALA 4JYAH 2GKRI 1HJAI 2M5XA 2SGDI 1MJBA 4B6DA 2K9HA 1X4SA 5BR8H 1KHMA 1P9ZA 3EZJA 3GOXA 2PQUA 5K36G 2CPQA 3SEKC 1ULKA 1UG8A 2CTFA 1WGTA 4BA2I 3U1KA 2JE6I 2CWFA 3L7ZC 2UU9H 4IFDG 4AIMA 3OL0A 5JEAG 1Z2IA 2JZMA 1VIGA 4LF4H 2CTMA 2NN6G 1V8CA 2ORWA 2NU1I 1DT4A 2M6QA 3T1HH 3RF2A 5IT9W 3OETA 4HGUA 4DR1H 4X66H 1YU6C 4AQYH 4E9JA 2LF0A 3KDGA 1FAQA 4E1RA 3R5BA 4FJUA 2N71A 3TOAA 2ZM6H 3MEKA 2ANNA 3FC3A 3RU0A 2WVJA 1IBKH 4DR5H 1PQXA 2RC4A 1KBEA 2N17A 2JXDA 1TBOA 1ULMA 3VKEA 1CE3A 4JI8H 2CTEA 1MJ9A 2CWGA 1X74A 3B4VC 1OMTA 2OPUA 2A20A 2SGFI 1UHAA 2DGRA 5A2QW 2ARPF 4GKKH 3J80W 4WANA 2UUAH 1XRHA 1LR9A 1M8BA 1SGQI 2F4VH 1IBLH 1TOTA 4DR2H 1V1HA 3E2IA 1WVNA 3UGIA 3GKUA 4DV3H 4DV1H 1M8CA 4LFBH 3OSSD 2LTMA 5FUWA 3SB1A 4OD6A 1V9NA 4JI2H 2BL5A 2ANRA 2E5RA 1CSOI 7WGAA 2VQEH 2E5LH 2NU0I 4OCHA 5LL6b 1HPTA 1OYVI 4YY3H 3FAUA 1OMUA 5FUXA 4AMLA 2QQCA 1R79A 2JEBI 3VE5A 2A1SA 5LMUH 4GKJH 1IW4A 2Y0MA 5C0XG 2OVOA 2J87A 1KBFA 1DTJA 1WTJA 1XA6A 1VDDA 1V1IA 4JVHA 1DS2I 5EX3A 3FSYA 2NU3I 2FNFX 2ODDA 2B8TA 4YHHH 3R5CA 2X52A 1AN7A 5CCLA 2RIJA 1AN1I 1Y1BA 3J81W 1MT1A 4GI3C 2FPHX 4DV6H 2CPMA 2QQEA 1J5KA 2PQ8A 2VQFH 1PTRA 4OO1G 1HDLA 1SGEI 1CGII 3UEYA 2UUCH 3OXGA 1FARA 3HH2C 3GABA 1VBIA 2OD1A 5DAEA 3UOEA 2Y3MA 4A24A 2QPOA 4NXNH 1ZZKA 1IY6A 1CT0I 1FKAH 2M8WA 2DKVA 1TBRR 4LF7H 3GR5A 1HEVA 2HH3A 4NZTM 1SGDI 2GKTI 1FY7A 4LF5H 3V69A 3OXFA 2KCXA 1SGYI 1XNRH 5HI7A 5E3QA 1K7VA 3UFFA 2HH2A 4LF6H 2PT7G 2NU4I 1IY5A 4DV2H 2L7XA 4L9MA 3UGLA 2WCYA 3QTLD 4JI0H 4DR4H 2KMQA 2UZ3A 3R5AA 2HHHH 4DR7H 4B3RH 1X4NA 3TJQA 4QMFB 4JI7H 2ERWA 1N36H 1SGPI 4DR6H 3J7AK 1IBMH 1K7UA 1YTPA 2QQDA 1UUCA 2XRCA 2D9IA 2KMPA 5FLXW 2GVIA 1W3SA 3OVOA 4LFAH 3OXLA 4X64H 3OTOH 1XMOH 2V53A 1H0ZA 2ELIA 4DV0H 5FUYA 3QAHA 1HNZH 1J5EH 4E1PA 1K1GA 1I94H 2N52A 4PDBA 1U5KA 5IWAH 2JZXA 5LMNH 2CTKA 1DS3I 4X65H 1CHOI 2V1CC
chains in the Genus database with same CATH topology
2G8YA 1WTJA 1X0AA 1Z2IA 4FJUA 2CWFA 4FJSA 1V9NA 1XRHA 2CWHA 3UOEA 4H8AA 1VBIA 1S20A 2X06A 3I0PA 1NXUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2G8Y A;  1WTJ A;  1X0A A;  1Z2I A;  4FJU A;  2CWF A;  4FJS A;  1V9N A;  1XRH A;  2CWH A;  3UOE A;  4H8A A;  1VBI A;  1S20 A;  2X06 A;  3I0P A;  1NXU A; 
#chains in the Genus database with same CATH topology
 5E3P A;  1BMO A;  3KDK A;  1PCE A;  2P2R A;  3KY9 A;  2JW6 A;  5JHW C;  1ZZJ A;  2F3C I;  1Y8F A;  2YUU A;  1X4M A;  4LF8 H;  1XBT A;  1NXU A;  4B3T H;  4LFC H;  1N32 H;  3PDN A;  1HNX H;  2WGC A;  3I0P A;  4JCV E;  4NZR M;  1MSZ A;  2FFM A;  1S03 G;  2UXC H;  4OVO A;  3JAM W;  1TBQ R;  1WHR A;  3E59 A;  3UEJ A;  3CXL A;  4G08 A;  2G8Y A;  1PTQ A;  1HR0 H;  2JYY A;  5J8C A;  4LIJ A;  2ENZ A;  2MJH A;  1CT2 I;  1ZTG A;  2SGP I;  1SGN I;  2GIV A;  1Y1C A;  1S20 A;  2DB6 A;  2DIP A;  2CTL A;  3T1Y H;  3TOB A;  4B8C D;  2UXD H;  2LB7 A;  3AEV B;  1ZZI A;  1BUS A;  1P9G A;  2SGE I;  4JI5 H;  2JEA I;  4DUZ H;  4K0K H;  2JVZ A;  1Z7K B;  1WKX A;  4H8A A;  2J9R A;  1PPF I;  1I6U A;  3TO9 A;  2L8E A;  1XX6 A;  2CJS C;  2V1C A;  2LTL A;  4WP4 A;  4X62 H;  4UXJ A;  1UVF A;  2QND A;  2VKC A;  2E3U A;  5E3R A;  4AM3 A;  1XMQ H;  1NUB A;  3SGQ I;  9WGA A;  3FSX A;  2SGQ I;  4B8T A;  2FMR A;  1RFH A;  4LF9 H;  1N13 A;  2VRW B;  4FKD A;  4DV5 H;  1TIH A;  2P6A C;  1VIH A;  2KMO A;  4OX9 H;  1Q9B A;  5J8F A;  2OU2 A;  1J4W A;  4JI4 H;  5FUV A;  4NBQ A;  1LR7 A;  3TO7 A;  1TUA A;  2W0T A;  1R0R I;  2ROW A;  4DV4 H;  1WGC A;  3VDU A;  1MJA A;  3QD7 X;  4JVY A;  3UGD A;  1ODH A;  1SEI A;  2O4C A;  4DR3 H;  4DNC A;  4JI3 H;  2E73 A;  3TO6 A;  2JA9 A;  4SGB I;  2CTJ A;  2LEO A;  1SGR I;  1UVG A;  4FJS A;  1W4R A;  4B3M H;  2X06 A;  1WE8 A;  1TGS I;  2LUY A;  1X9Z A;  2NU2 I;  1N34 H;  4JV5 H;  4NXM H;  3BJI A;  1F0X A;  4EC5 A;  4DV7 H;  5CCM A;  2YQR A;  1K7T A;  2UUB H;  2OPV A;  1XNQ H;  1TBN A;  2BA0 A;  4BA1 I;  3D00 A;  1PJU A;  2BUS A;  4UXH A;  4JI1 H;  1OVO A;  2X3T A;  2QQ0 A;  2LRR A;  2JA1 A;  5HQ8 A;  1TUR A;  2KMR A;  2UVO A;  2ZQE A;  1TUS A;  1LR8 A;  1ULN A;  4B3S H;  4JI6 H;  2OZU A;  2ENN A;  1CT4 I;  3R5D A;  1CGJ I;  4MPI A;  1FJG H;  2CWH A;  2K1H A;  2AXY A;  1HNW H;  1EC6 A;  2ORV A;  1N33 H;  4UXI A;  5DT9 A;  3QWP A;  5EX0 A;  2YQP A;  3SGB I;  2PY9 A;  1X0A A;  2B0U C;  4KHP H;  1FYB A;  1KMA A;  3NCV A;  4DUY H;  2N1A B;  3VDP A;  2UXB H;  2GKV A;  2Z0S A;  4WAL A;  4JYA H;  2GKR I;  1HJA I;  2M5X A;  2SGD I;  1MJB A;  4B6D A;  2K9H A;  1X4S A;  5BR8 H;  1KHM A;  1P9Z A;  3EZJ A;  3GOX A;  2PQU A;  5K36 G;  2CPQ A;  3SEK C;  1ULK A;  1UG8 A;  2CTF A;  1WGT A;  4BA2 I;  3U1K A;  2JE6 I;  2CWF A;  3L7Z C;  2UU9 H;  4IFD G;  4AIM A;  3OL0 A;  5JEA G;  1Z2I A;  2JZM A;  1VIG A;  4LF4 H;  2CTM A;  2NN6 G;  1V8C A;  2ORW A;  2NU1 I;  1DT4 A;  2M6Q A;  3T1H H;  3RF2 A;  5IT9 W;  3OET A;  4HGU A;  4DR1 H;  4X66 H;  1YU6 C;  4AQY H;  4E9J A;  2LF0 A;  3KDG A;  1FAQ A;  4E1R A;  3R5B A;  4FJU A;  2N71 A;  3TOA A;  2ZM6 H;  3MEK A;  2ANN A;  3FC3 A;  3RU0 A;  2WVJ A;  1IBK H;  4DR5 H;  1PQX A;  2RC4 A;  1KBE A;  2N17 A;  2JXD A;  1TBO A;  1ULM A;  3VKE A;  1CE3 A;  4JI8 H;  2CTE A;  1MJ9 A;  2CWG A;  1X74 A;  3B4V C;  1OMT A;  2OPU A;  2A20 A;  2SGF I;  1UHA A;  2DGR A;  5A2Q W;  2ARP F;  4GKK H;  3J80 W;  4WAN A;  2UUA H;  1XRH A;  1LR9 A;  1M8B A;  1SGQ I;  2F4V H;  1IBL H;  1TOT A;  4DR2 H;  1V1H A;  3E2I A;  1WVN A;  3UGI A;  3GKU A;  4DV3 H;  4DV1 H;  1M8C A;  4LFB H;  3OSS D;  2LTM A;  5FUW A;  3SB1 A;  4OD6 A;  1V9N A;  4JI2 H;  2BL5 A;  2ANR A;  2E5R A;  1CSO I;  7WGA A;  2VQE H;  2E5L H;  2NU0 I;  4OCH A;  5LL6 b;  1HPT A;  1OYV I;  4YY3 H;  3FAU A;  1OMU A;  5FUX A;  4AML A;  2QQC A;  1R79 A;  2JEB I;  3VE5 A;  2A1S A;  5LMU H;  4GKJ H;  1IW4 A;  2Y0M A;  5C0X G;  2OVO A;  2J87 A;  1KBF A;  1DTJ A;  1WTJ A;  1XA6 A;  1VDD A;  1V1I A;  4JVH A;  1DS2 I;  5EX3 A;  3FSY A;  2NU3 I;  2FNF X;  2ODD A;  2B8T A;  4YHH H;  3R5C A;  2X52 A;  1AN7 A;  5CCL A;  2RIJ A;  1AN1 I;  1Y1B A;  3J81 W;  1MT1 A;  4GI3 C;  2FPH X;  4DV6 H;  2CPM A;  2QQE A;  1J5K A;  2PQ8 A;  2VQF H;  1PTR A;  4OO1 G;  1HDL A;  1SGE I;  1CGI I;  3UEY A;  2UUC H;  3OXG A;  1FAR A;  3HH2 C;  3GAB A;  1VBI A;  2OD1 A;  5DAE A;  3UOE A;  2Y3M A;  4A24 A;  2QPO A;  4NXN H;  1ZZK A;  1IY6 A;  1CT0 I;  1FKA H;  2M8W A;  2DKV A;  1TBR R;  4LF7 H;  3GR5 A;  1HEV A;  2HH3 A;  4NZT M;  1SGD I;  2GKT I;  1FY7 A;  4LF5 H;  3V69 A;  3OXF A;  2KCX A;  1SGY I;  1XNR H;  5HI7 A;  5E3Q A;  1K7V A;  3UFF A;  2HH2 A;  4LF6 H;  2PT7 G;  2NU4 I;  1IY5 A;  4DV2 H;  2L7X A;  4L9M A;  3UGL A;  2WCY A;  3QTL D;  4JI0 H;  4DR4 H;  2KMQ A;  2UZ3 A;  3R5A A;  2HHH H;  4DR7 H;  4B3R H;  1X4N A;  3TJQ A;  4QMF B;  4JI7 H;  2ERW A;  1N36 H;  1SGP I;  4DR6 H;  3J7A K;  1IBM H;  1K7U A;  1YTP A;  2QQD A;  1UUC A;  2XRC A;  2D9I A;  2KMP A;  5FLX W;  2GVI A;  1W3S A;  3OVO A;  4LFA H;  3OXL A;  4X64 H;  3OTO H;  1XMO H;  2V53 A;  1H0Z A;  2ELI A;  4DV0 H;  5FUY A;  3QAH A;  1HNZ H;  1J5E H;  4E1P A;  1K1G A;  1I94 H;  2N52 A;  4PDB A;  1U5K A;  5IWA H;  2JZX A;  5LMN H;  2CTK A;  1DS3 I;  4X65 H;  1CHO I;  2V1C C; 
#chains in the Genus database with same CATH homology
 2G8Y A;  1WTJ A;  1X0A A;  1Z2I A;  4FJU A;  2CWF A;  4FJS A;  1V9N A;  1XRH A;  2CWH A;  3UOE A;  4H8A A;  1VBI A;  1S20 A;  2X06 A;  3I0P A;  1NXU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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