1S20A

A novel nad binding protein revealed by the crystal structure of e. coli 2,3-diketogulonate reductase (yiak) northeast structural genomics consortium target er82
Total Genus 98
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
98
sequence length
334
structure length
334
Chain Sequence
MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQALLE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Hypothetical oxidoreductase yiaK
publication title A Novel NAD-binding Protein Revealed by the Crystal Structure of 2,3-Diketo-L-gulonate Reductase (YiaK).
pubmed doi rcsb
source organism Escherichia coli
molecule tags Oxidoreductase
total genus 98
structure length 334
sequence length 334
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 1.1.1.130: 3-dehydro-L-gulonate 2-dehydrogenase.
pdb deposition date 2004-01-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02615 Ldh_2 Malate/L-lactate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1530.10 Mainly Alpha Orthogonal Bundle Hypothetical Oxidoreductase Yiak; Chain: A, domain 1 Hypothetical Oxidoreductase Yiak; Chain: A, domain 1 1s20A01
3.30.60.50 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Hypothetical oxidoreductase yiak; domain 3 1s20A03
3.30.1370.60 Alpha Beta 2-Layer Sandwich Ribosomal Protein S8; Chain: A, domain 1 Hypothetical oxidoreductase yiak; domain 2 1s20A02
2CWHA 1S20A 4FJUA 2CWFA 2X06A 1XRHA 3UOEA 1X0AA 1NXUA 1VBIA 1V9NA 2G8YA 1WTJA 4FJSA 4H8AA 1Z2IA 3I0PA
chains in the Genus database with same CATH superfamily
3OL0A 1KBFA 2N52A 2YQRA 3TO9A 2KMQA 1F0XA 3B4VC 1SEIA 2DGRA 1PPFI 1CE3A 2CTEA 2XRCA 1HEVA 3SGBI 3EZJA 2NU1I 4DUZH 3UEYA 2CTLA 4K0KH 1U5KA 1W4RA 1KHMA 1LR7A 2OVOA 2GIVA 2A1SA 4OVOA 5FUVA 2NU3I 2ORWA 4LF7H 1PCEA 4JI5H 1DS2I 2DIPA 4LF4H 2JE6I 4YHHH 3KDKA 1DTJA 2AXYA 1WVNA 2P6AC 4DV7H 2CWFA 1CT4I 2UUBH 5E3QA 2W0TA 5HQ8A 1BUSA 4LF6H 2SGEI 1X74A 2QQDA 2LTMA 5EX3A 2VQEH 4E9JA 2D9IA 4LIJA 1LR8A 2UUCH 1Y8FA 1DS3I 3OXLA 9WGAA 4AQYH 2UZ3A 1WGCA 1IY6A 4LF5H 2CJSC 2OZUA 3GKUA 1CT0I 4NZTM 4WP4A 4NBQA 1N33H 3E59A 4KHPH 1TIHA 1CGJI 1UHAA 4B6DA 3TOBA 4FJSA 3R5AA 1HNXH 2UU9H 2UXCH 2B0UC 2Y3MA 5IWAH 3OVOA 2OPUA 1AN1I 1DT4A 4DV4H 1K7UA 2F3CI 1ODHA 4JI1H 1TURA 3GOXA 2KMOA 1MT1A 1YU6C 5E3RA 5A2QW 2GVIA 1CT2I 5E3PA 3SGQI 1XA6A 2BL5A 2N1AB 5LMNH 2UXDH 1XNQH 4H8AA 3QTLD 2PY9A 2P2RA 4JV5H 2J9RA 4NXMH 1XBTA 4DR5H 3QWPA 4LFAH 3AEVB 3UEJA 1PTQA 1Q9BA 4DR4H 1EC6A 1P9ZA 4X64H 3TOAA 1WGTA 3L7ZC 1SGRI 1TGSI 5BR8H 2SGDI 5IT9W 1SGEI 2CPQA 4JI4H 2UUAH 1Z2IA 2E73A 3E2IA 2JW6A 1KMAA 1IBMH 4BA1I 2K1HA 2ORVA 4E1RA 1MJ9A 1V1IA 4JCVE 1ULNA 2NN6G 3UFFA 2LTLA 1ZTGA 4JI3H 2JVZA 1X4SA 1UVGA 4WANA 4DNCA 1SGNI 1SGDI 5FUXA 4OO1G 1OMUA 4JI8H 4LF8H 4B8TA 1HPTA 7WGAA 4B3SH 4DR6H 2DB6A 1WTJA 2OPVA 1IBKH 4FKDA 1HDLA 1XMOH 1VBIA 1CGII 4E1PA 2KMPA 4AM3A 4QMFB 2L7XA 3R5CA 4FJUA 1Y1CA 3FSYA 2SGFI 2GKVA 1NUBA 1N13A 1I94H 3QAHA 4GI3C 1X9ZA 2M5XA 2CTJA 2FMRA 2JEAI 1K7TA 1RFHA 4B3RH 2ERWA 2JA1A 1X4NA 1Z7KB 4NZRM 2V53A 2CTFA 1ULKA 4JI7H 3UGLA 1ZZKA 2ARPF 3NCVA 2M6QA 1N36H 1S20A 2WGCA 2ENZA 2E5LH 1FYBA 1R79A 1WKXA 4BA2I 2UVOA 5CCMA 5C0XG 4UXIA 1CHOI 4B3MH 1VIHA 3V69A 1NXUA 3VE5A 3TJQA 1UG8A 1OYVI 3PDNA 2B8TA 1N32H 1VDDA 5K36G 4JI2H 3VDPA 3R5BA 2GKTI 4B3TH 2RIJA 1ZZJA 3HH2C 1FARA 4DV3H 2N17A 4DR1H 1X4MA 1J5KA 1TOTA 2X3TA 1I6UA 1SGQI 1XNRH 4G08A 2KMRA 4JYAH 5EX0A 2SGPI 2SGQI 1MSZA 2NU4I 2L8EA 1PJUA 3T1YH 5HI7A 3OSSD 2PT7G 4UXHA 5FUWA 1IY5A 1IBLH 3VDUA 2CTMA 2HH3A 3SEKC 2E3UA 2X52A 3JAMW 3UGDA 4DR7H 4DV5H 4B8CD 1OMTA 2O4CA 4UXJA 3SB1A 2BUSA 1PTRA 4JVHA 1LR9A 2E5RA 1J5EH 5CCLA 5DT9A 2LUYA 1FKAH 2DKVA 4AIMA 3FC3A 4LF9H 1CSOI 1FAQA 4NXNH 2HHHH 2J87A 4LFBH 1H0ZA 5JHWC 4JI6H 1XX6A 4JVYA 1K7VA 1Y1BA 1HNZH 2ZQEA 4IFDG 2FPHX 2G8YA 2V1CA 3KDGA 2QPOA 1TBQR 4X65H 2CPMA 4GKJH 3CXLA 5LMUH 2M8WA 3J80W 1M8BA 2ODDA 1TBNA 2CTKA 4X66H 2QNDA 3J81W 2N71A 2CWHA 3OETA 4L9MA 1J4WA 3VKEA 2YUUA 1R0RI 2ELIA 3OXFA 1VIGA 2FNFX 1KBEA 2UXBH 2LB7A 2HH2A 1V1HA 3OXGA 1XRHA 2YQPA 5JEAG 1K1GA 1FJGH 3RF2A 2QQEA 2OD1A 1W3SA 4X62H 2VRWB 4HGUA 4PDBA 3D00A 3MEKA 3OTOH 2RC4A 3UOEA 1XMQH 2X06A 2JYYA 3TO7A 1PQXA 2QQCA 1OVOA 1M8CA 2Z0SA 2QQ0A 2OU2A 2LF0A 2JZMA 3KY9A 2JZXA 2PQUA 2LEOA 3J7AK 2GKRI 3TO6A 1WE8A 4DV0H 4OD6A 3BJIA 4JI0H 2A20A 1TUAA 4OX9H 1IW4A 5J8FA 2PQ8A 1TBRR 1HR0H 2K9HA 1HJAI 3QD7X 2MJHA 5J8CA 1UVFA 2JEBI 2LRRA 2VKCA 4OCHA 1P9GA 4GKKH 2NU0I 3R5DA 3GR5A 1ZZIA 1N34H 1MJBA 1BMOA 1V8CA 3FSXA 4DR2H 2JXDA 5FUYA 4DV6H 3I0PA 3RU0A 2BA0A 3T1HH 4A24A 1V9NA 2ENNA 2JA9A 2WVJA 4LFCH 4MPIA 2FFMA 2ANNA 2CWGA 1SGPI 1X0AA 1UUCA 1AN7A 4AMLA 1HNWH 2NU2I 4DV2H 2KCXA 5LL6b 4WALA 1FY7A 2F4VH 2ANRA 3GABA 4YY3H 1WHRA 1S03G 1YTPA 2V1CC 1SGYI 1TBOA 4SGBI 5DAEA 2Y0MA 3U1KA 3UGIA 5FLXW 2ZM6H 1MJAA 4DV1H 2ROWA 1ULMA 2WCYA 2VQFH 3FAUA 4DUYH 4DR3H 1TUSA 4EC5A
chains in the Genus database with same CATH topology
2CWHA 1S20A 4FJUA 2CWFA 2X06A 1XRHA 3UOEA 1X0AA 1NXUA 1VBIA 1V9NA 2G8YA 1WTJA 4FJSA 4H8AA 1Z2IA 3I0PA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2CWH A;  1S20 A;  4FJU A;  2CWF A;  2X06 A;  1XRH A;  3UOE A;  1X0A A;  1NXU A;  1VBI A;  1V9N A;  2G8Y A;  1WTJ A;  4FJS A;  4H8A A;  1Z2I A;  3I0P A; 
#chains in the Genus database with same CATH topology
 3OL0 A;  1KBF A;  2N52 A;  2YQR A;  3TO9 A;  2KMQ A;  1F0X A;  3B4V C;  1SEI A;  2DGR A;  1PPF I;  1CE3 A;  2CTE A;  2XRC A;  1HEV A;  3SGB I;  3EZJ A;  2NU1 I;  4DUZ H;  3UEY A;  2CTL A;  4K0K H;  1U5K A;  1W4R A;  1KHM A;  1LR7 A;  2OVO A;  2GIV A;  2A1S A;  4OVO A;  5FUV A;  2NU3 I;  2ORW A;  4LF7 H;  1PCE A;  4JI5 H;  1DS2 I;  2DIP A;  4LF4 H;  2JE6 I;  4YHH H;  3KDK A;  1DTJ A;  2AXY A;  1WVN A;  2P6A C;  4DV7 H;  2CWF A;  1CT4 I;  2UUB H;  5E3Q A;  2W0T A;  5HQ8 A;  1BUS A;  4LF6 H;  2SGE I;  1X74 A;  2QQD A;  2LTM A;  5EX3 A;  2VQE H;  4E9J A;  2D9I A;  4LIJ A;  1LR8 A;  2UUC H;  1Y8F A;  1DS3 I;  3OXL A;  9WGA A;  4AQY H;  2UZ3 A;  1WGC A;  1IY6 A;  4LF5 H;  2CJS C;  2OZU A;  3GKU A;  1CT0 I;  4NZT M;  4WP4 A;  4NBQ A;  1N33 H;  3E59 A;  4KHP H;  1TIH A;  1CGJ I;  1UHA A;  4B6D A;  3TOB A;  4FJS A;  3R5A A;  1HNX H;  2UU9 H;  2UXC H;  2B0U C;  2Y3M A;  5IWA H;  3OVO A;  2OPU A;  1AN1 I;  1DT4 A;  4DV4 H;  1K7U A;  2F3C I;  1ODH A;  4JI1 H;  1TUR A;  3GOX A;  2KMO A;  1MT1 A;  1YU6 C;  5E3R A;  5A2Q W;  2GVI A;  1CT2 I;  5E3P A;  3SGQ I;  1XA6 A;  2BL5 A;  2N1A B;  5LMN H;  2UXD H;  1XNQ H;  4H8A A;  3QTL D;  2PY9 A;  2P2R A;  4JV5 H;  2J9R A;  4NXM H;  1XBT A;  4DR5 H;  3QWP A;  4LFA H;  3AEV B;  3UEJ A;  1PTQ A;  1Q9B A;  4DR4 H;  1EC6 A;  1P9Z A;  4X64 H;  3TOA A;  1WGT A;  3L7Z C;  1SGR I;  1TGS I;  5BR8 H;  2SGD I;  5IT9 W;  1SGE I;  2CPQ A;  4JI4 H;  2UUA H;  1Z2I A;  2E73 A;  3E2I A;  2JW6 A;  1KMA A;  1IBM H;  4BA1 I;  2K1H A;  2ORV A;  4E1R A;  1MJ9 A;  1V1I A;  4JCV E;  1ULN A;  2NN6 G;  3UFF A;  2LTL A;  1ZTG A;  4JI3 H;  2JVZ A;  1X4S A;  1UVG A;  4WAN A;  4DNC A;  1SGN I;  1SGD I;  5FUX A;  4OO1 G;  1OMU A;  4JI8 H;  4LF8 H;  4B8T A;  1HPT A;  7WGA A;  4B3S H;  4DR6 H;  2DB6 A;  1WTJ A;  2OPV A;  1IBK H;  4FKD A;  1HDL A;  1XMO H;  1VBI A;  1CGI I;  4E1P A;  2KMP A;  4AM3 A;  4QMF B;  2L7X A;  3R5C A;  4FJU A;  1Y1C A;  3FSY A;  2SGF I;  2GKV A;  1NUB A;  1N13 A;  1I94 H;  3QAH A;  4GI3 C;  1X9Z A;  2M5X A;  2CTJ A;  2FMR A;  2JEA I;  1K7T A;  1RFH A;  4B3R H;  2ERW A;  2JA1 A;  1X4N A;  1Z7K B;  4NZR M;  2V53 A;  2CTF A;  1ULK A;  4JI7 H;  3UGL A;  1ZZK A;  2ARP F;  3NCV A;  2M6Q A;  1N36 H;  1S20 A;  2WGC A;  2ENZ A;  2E5L H;  1FYB A;  1R79 A;  1WKX A;  4BA2 I;  2UVO A;  5CCM A;  5C0X G;  4UXI A;  1CHO I;  4B3M H;  1VIH A;  3V69 A;  1NXU A;  3VE5 A;  3TJQ A;  1UG8 A;  1OYV I;  3PDN A;  2B8T A;  1N32 H;  1VDD A;  5K36 G;  4JI2 H;  3VDP A;  3R5B A;  2GKT I;  4B3T H;  2RIJ A;  1ZZJ A;  3HH2 C;  1FAR A;  4DV3 H;  2N17 A;  4DR1 H;  1X4M A;  1J5K A;  1TOT A;  2X3T A;  1I6U A;  1SGQ I;  1XNR H;  4G08 A;  2KMR A;  4JYA H;  5EX0 A;  2SGP I;  2SGQ I;  1MSZ A;  2NU4 I;  2L8E A;  1PJU A;  3T1Y H;  5HI7 A;  3OSS D;  2PT7 G;  4UXH A;  5FUW A;  1IY5 A;  1IBL H;  3VDU A;  2CTM A;  2HH3 A;  3SEK C;  2E3U A;  2X52 A;  3JAM W;  3UGD A;  4DR7 H;  4DV5 H;  4B8C D;  1OMT A;  2O4C A;  4UXJ A;  3SB1 A;  2BUS A;  1PTR A;  4JVH A;  1LR9 A;  2E5R A;  1J5E H;  5CCL A;  5DT9 A;  2LUY A;  1FKA H;  2DKV A;  4AIM A;  3FC3 A;  4LF9 H;  1CSO I;  1FAQ A;  4NXN H;  2HHH H;  2J87 A;  4LFB H;  1H0Z A;  5JHW C;  4JI6 H;  1XX6 A;  4JVY A;  1K7V A;  1Y1B A;  1HNZ H;  2ZQE A;  4IFD G;  2FPH X;  2G8Y A;  2V1C A;  3KDG A;  2QPO A;  1TBQ R;  4X65 H;  2CPM A;  4GKJ H;  3CXL A;  5LMU H;  2M8W A;  3J80 W;  1M8B A;  2ODD A;  1TBN A;  2CTK A;  4X66 H;  2QND A;  3J81 W;  2N71 A;  2CWH A;  3OET A;  4L9M A;  1J4W A;  3VKE A;  2YUU A;  1R0R I;  2ELI A;  3OXF A;  1VIG A;  2FNF X;  1KBE A;  2UXB H;  2LB7 A;  2HH2 A;  1V1H A;  3OXG A;  1XRH A;  2YQP A;  5JEA G;  1K1G A;  1FJG H;  3RF2 A;  2QQE A;  2OD1 A;  1W3S A;  4X62 H;  2VRW B;  4HGU A;  4PDB A;  3D00 A;  3MEK A;  3OTO H;  2RC4 A;  3UOE A;  1XMQ H;  2X06 A;  2JYY A;  3TO7 A;  1PQX A;  2QQC A;  1OVO A;  1M8C A;  2Z0S A;  2QQ0 A;  2OU2 A;  2LF0 A;  2JZM A;  3KY9 A;  2JZX A;  2PQU A;  2LEO A;  3J7A K;  2GKR I;  3TO6 A;  1WE8 A;  4DV0 H;  4OD6 A;  3BJI A;  4JI0 H;  2A20 A;  1TUA A;  4OX9 H;  1IW4 A;  5J8F A;  2PQ8 A;  1TBR R;  1HR0 H;  2K9H A;  1HJA I;  3QD7 X;  2MJH A;  5J8C A;  1UVF A;  2JEB I;  2LRR A;  2VKC A;  4OCH A;  1P9G A;  4GKK H;  2NU0 I;  3R5D A;  3GR5 A;  1ZZI A;  1N34 H;  1MJB A;  1BMO A;  1V8C A;  3FSX A;  4DR2 H;  2JXD A;  5FUY A;  4DV6 H;  3I0P A;  3RU0 A;  2BA0 A;  3T1H H;  4A24 A;  1V9N A;  2ENN A;  2JA9 A;  2WVJ A;  4LFC H;  4MPI A;  2FFM A;  2ANN A;  2CWG A;  1SGP I;  1X0A A;  1UUC A;  1AN7 A;  4AML A;  1HNW H;  2NU2 I;  4DV2 H;  2KCX A;  5LL6 b;  4WAL A;  1FY7 A;  2F4V H;  2ANR A;  3GAB A;  4YY3 H;  1WHR A;  1S03 G;  1YTP A;  2V1C C;  1SGY I;  1TBO A;  4SGB I;  5DAE A;  2Y0M A;  3U1K A;  3UGI A;  5FLX W;  2ZM6 H;  1MJA A;  4DV1 H;  2ROW A;  1ULM A;  2WCY A;  2VQF H;  3FAU A;  4DUY H;  4DR3 H;  1TUS A;  4EC5 A; 
#chains in the Genus database with same CATH homology
 2CWH A;  1S20 A;  4FJU A;  2CWF A;  2X06 A;  1XRH A;  3UOE A;  1X0A A;  1NXU A;  1VBI A;  1V9N A;  2G8Y A;  1WTJ A;  4FJS A;  4H8A A;  1Z2I A;  3I0P A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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