1S20A

A novel nad binding protein revealed by the crystal structure of e. coli 2,3-diketogulonate reductase (yiak) northeast structural genomics consortium target er82
Total Genus 98
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
98
sequence length
334
structure length
334
Chain Sequence
MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTQDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQAIRLPGHEFTTLLAENRRNGITVDDSVWAKIQALLE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A Novel NAD-binding Protein Revealed by the Crystal Structure of 2,3-Diketo-L-gulonate Reductase (YiaK).
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Escherichia coli
molecule keywords Hypothetical oxidoreductase yiaK
total genus 98
structure length 334
sequence length 334
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 1.1.1.130: 3-dehydro-L-gulonate 2-dehydrogenase.
pdb deposition date 2004-01-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02615 Ldh_2 Malate/L-lactate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1530.10 Mainly Alpha Orthogonal Bundle Hypothetical Oxidoreductase Yiak; Chain: A, domain 1 Hypothetical Oxidoreductase Yiak; Chain: A, domain 1 1s20A01
3.30.60.50 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Hypothetical oxidoreductase yiak; domain 3 1s20A03
3.30.1370.60 Alpha Beta 2-Layer Sandwich Ribosomal Protein S8; Chain: A, domain 1 Hypothetical oxidoreductase yiak; domain 2 1s20A02
1XRHA 1S20A 4FJSA 4H8AA 2CWHA 4FJUA 3I0PA 2CWFA 1Z2IA 3UOEA 1V9NA 1NXUA 1WTJA 2G8YA 2X06A 1X0AA 1VBIA
chains in the Genus database with same CATH superfamily
4DR2H 2ARPF 2DIPA 3FSXA 2OZUA 2FNFX 1Y1CA 1FYBA 5HI7A 3QTLD 5J8CA 2LF0A 2ANNA 2ODDA 2RIJA 4G08A 5K36G 1BMOA 2K1HA 4UXHA 1Z2IA 1UVFA 1XNRH 2UVOA 2YUUA 3E2IA 1J5KA 4NZRM 3OXFA 5DT9A 1ULKA 1HNWH 3KDKA 2WGCA 4OX9H 3JAMW 3E59A 2ORWA 4JI0H 1XMQH 2WVJA 2RC4A 1ZZIA 4DR5H 1Y8FA 2Y3MA 1SEIA 4B8TA 1IBKH 2XRCA 1LR8A 4EC5A 2JE6I 2VQEH 1K7TA 2PQ8A 1X9ZA 2CWFA 1TBRR 2G8YA 3B4VC 3R5CA 3GOXA 1DS3I 3RF2A 3D00A 4LFCH 1XNQH 4DNCA 5HQ8A 2GKRI 4DUYH 2NU0I 2SGEI 4FJSA 2GVIA 2ROWA 4SGBI 3U1KA 1WHRA 3TOAA 2OPUA 2UU9H 1MJBA 2VRWB 1FARA 1TBQR 1OYVI 1M8BA 1HNXH 3OSSD 2PY9A 2NU3I 4UXJA 5C0XG 4DV7H 2M8WA 3UGLA 1WGCA 3L7ZC 1VIGA 3VKEA 1LR9A 3SB1A 3SEKC 2DGRA 2FPHX 1VIHA 4JI3H 4E9JA 2ENZA 4WALA 1HJAI 1TBOA 4DV4H 1R79A 4GI3C 1UUCA 1IY6A 4YY3H 4LF8H 3QAHA 2QNDA 2PQUA 5FUYA 1XX6A 1KHMA 2HHHH 1WVNA 3SGQI 1PCEA 2DB6A 2UXBH 4DV1H 1K7VA 2A20A 1PTRA 2CJSC 2B8TA 1OVOA 2UXCH 4OVOA 4DR4H 3UEYA 1N13A 1DS2I 3OVOA 2ZM6H 4LF4H 1X74A 4X66H 4DR7H 1I6UA 2JW6A 2OPVA 3VDUA 3KDGA 2CTLA 2SGFI 3OXGA 1J5EH 3NCVA 1HR0H 1SGNI 1FY7A 4H8AA 1UVGA 2F4VH 1WKXA 4DV3H 3TO9A 4JI6H 2LB7A 4FKDA 3TO6A 2B0UC 3FC3A 1MT1A 1CE3A 2CPQA 4A24A 2CPMA 1Z7KB 2GKVA 2P6AC 2Y0MA 2E73A 1CT2I 3R5DA 3KY9A 2QQEA 1EC6A 1TBNA 2ELIA 1P9ZA 5CCLA 2CTMA 1M8CA 1FJGH 4DV5H 2CWGA 5DAEA 4B3RH 2CWHA 4LFAH 3PDNA 2CTEA 1YTPA 3HH2C 3J7AK 4X65H 4PDBA 5E3PA 4HGUA 3GABA 1XMOH 4BA1I 3TO7A 3UEJA 2L7XA 2JVZA 9WGAA 1RFHA 1SGPI 2M5XA 2MJHA 2BL5A 4IFDG 2SGDI 2GKTI 2JEBI 4GKKH 1HNZH 3GR5A 1NUBA 2KMPA 1AN1I 1SGYI 1TOTA 1KBEA 1X4MA 2D9IA 2QQDA 2LTMA 2N71A 4DUZH 4AM3A 4B3MH 1CGJI 2X06A 2NU2I 2KCXA 2SGQI 2JYYA 4AIMA 1FAQA 2P2RA 1W3SA 4AMLA 4OCHA 4DR1H 5IWAH 4LF7H 1LR7A 1TUAA 5CCMA 1YU6C 3R5AA 2ANRA 1X0AA 2F3CI 2ERWA 4FJUA 2N1AB 4DV2H 3T1YH 1X4NA 4B8CD 1CT4I 1NXUA 1PQXA 1TUSA 1SGEI 1V1HA 1V9NA 4BA2I 2ORVA 1ZZKA 2OD1A 4E1RA 2LEOA 4LFBH 4YHHH 1ZZJA 2M6QA 1VDDA 1PTQA 2V1CC 3GKUA 4GKJH 2YQRA 4LF6H 2JEAI 3VE5A 1DT4A 4L9MA 2UUAH 5EX3A 2BUSA 4MPIA 1TGSI 4LF5H 5JEAG 4WANA 3RU0A 4B6DA 4NZTM 5FUVA 2A1SA 3AEVB 3UOEA 2CTFA 2KMQA 3V69A 1N36H 4JI7H 5IT9W 2VQFH 4NXNH 2CTKA 5A2QW 4JV5H 1MJAA 4JVYA 7WGAA 2LUYA 1N34H 1MSZA 4DV0H 4QMFB 4B3TH 2N17A 1K7UA 2UXDH 2WCYA 1J4WA 2LRRA 1HPTA 2UUCH 1SGQI 1Y1BA 3TJQA 5FUXA 1CSOI 2HH2A 5JHWC 2JXDA 4NXMH 1V8CA 1UG8A 2V53A 2X52A 2BA0A 2OU2A 2FMRA 3OETA 4JI8H 1N32H 5LMNH 4UXIA 3FSYA 4JI4H 1W4RA 4JVHA 1X4SA 3BJIA 1F0XA 1DTJA 3QD7X 1IBLH 1SGRI 2J9RA 3I0PA 2J87A 1ODHA 2JA9A 3UGDA 2VKCA 2NN6G 4JI2H 3T1HH 4K0KH 2NU1I 2DKVA 2E5RA 2UUBH 2ENNA 1IY5A 2YQPA 1KBFA 5E3QA 1XA6A 1S20A 1V1IA 1BUSA 2ZQEA 1S03G 3CXLA 1ULNA 1P9GA 1PPFI 3R5BA 5J8FA 1WGTA 2JZMA 4JI5H 2UZ3A 4LF9H 1N33H 4E1PA 3J81W 1WE8A 2E5LH 4DR6H 3UFFA 5FUWA 5LL6b 1K1GA 4KHPH 1SGDI 1R0RI 2HH3A 1HDLA 2N52A 1Q9BA 4X64H 1PJUA 1CT0I 2W0TA 3VDPA 4AQYH 2SGPI 1CGII 2CTJA 5BR8H 4OO1G 3SGBI 2FFMA 2GIVA 2OVOA 1I94H 1XBTA 5LMUH 1H0ZA 4JYAH 1UHAA 2LTLA 3OXLA 3UGIA 2K9HA 3OL0A 4X62H 1XRHA 1OMUA 2L8EA 2O4CA 2KMOA 2E3UA 4LIJA 4OD6A 1TURA 2V1CA 1WTJA 1VBIA 3J80W 4JCVE 1ULMA 2X3TA 1TIHA 1AN7A 4B3SH 1OMTA 1HEVA 1IBMH 2KMRA 4JI1H 1MJ9A 3TOBA 2QQCA 4WP4A 1CHOI 2Z0SA 2PT7G 3MEKA 5E3RA 4DV6H 2JZXA 3FAUA 2JA1A 5FLXW 1U5KA 2QQ0A 1KMAA 4NBQA 2AXYA 4DR3H 1FKAH 5EX0A 3QWPA 3EZJA 2NU4I 2QPOA 1ZTGA 1IW4A 3OTOH
chains in the Genus database with same CATH topology
1XRHA 1S20A 4FJSA 4H8AA 2CWHA 4FJUA 3I0PA 2CWFA 1Z2IA 3UOEA 1V9NA 1NXUA 1WTJA 2G8YA 2X06A 1X0AA 1VBIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XRH A;  1S20 A;  4FJS A;  4H8A A;  2CWH A;  4FJU A;  3I0P A;  2CWF A;  1Z2I A;  3UOE A;  1V9N A;  1NXU A;  1WTJ A;  2G8Y A;  2X06 A;  1X0A A;  1VBI A; 
#chains in the Genus database with same CATH topology
 4DR2 H;  2ARP F;  2DIP A;  3FSX A;  2OZU A;  2FNF X;  1Y1C A;  1FYB A;  5HI7 A;  3QTL D;  5J8C A;  2LF0 A;  2ANN A;  2ODD A;  2RIJ A;  4G08 A;  5K36 G;  1BMO A;  2K1H A;  4UXH A;  1Z2I A;  1UVF A;  1XNR H;  2UVO A;  2YUU A;  3E2I A;  1J5K A;  4NZR M;  3OXF A;  5DT9 A;  1ULK A;  1HNW H;  3KDK A;  2WGC A;  4OX9 H;  3JAM W;  3E59 A;  2ORW A;  4JI0 H;  1XMQ H;  2WVJ A;  2RC4 A;  1ZZI A;  4DR5 H;  1Y8F A;  2Y3M A;  1SEI A;  4B8T A;  1IBK H;  2XRC A;  1LR8 A;  4EC5 A;  2JE6 I;  2VQE H;  1K7T A;  2PQ8 A;  1X9Z A;  2CWF A;  1TBR R;  2G8Y A;  3B4V C;  3R5C A;  3GOX A;  1DS3 I;  3RF2 A;  3D00 A;  4LFC H;  1XNQ H;  4DNC A;  5HQ8 A;  2GKR I;  4DUY H;  2NU0 I;  2SGE I;  4FJS A;  2GVI A;  2ROW A;  4SGB I;  3U1K A;  1WHR A;  3TOA A;  2OPU A;  2UU9 H;  1MJB A;  2VRW B;  1FAR A;  1TBQ R;  1OYV I;  1M8B A;  1HNX H;  3OSS D;  2PY9 A;  2NU3 I;  4UXJ A;  5C0X G;  4DV7 H;  2M8W A;  3UGL A;  1WGC A;  3L7Z C;  1VIG A;  3VKE A;  1LR9 A;  3SB1 A;  3SEK C;  2DGR A;  2FPH X;  1VIH A;  4JI3 H;  4E9J A;  2ENZ A;  4WAL A;  1HJA I;  1TBO A;  4DV4 H;  1R79 A;  4GI3 C;  1UUC A;  1IY6 A;  4YY3 H;  4LF8 H;  3QAH A;  2QND A;  2PQU A;  5FUY A;  1XX6 A;  1KHM A;  2HHH H;  1WVN A;  3SGQ I;  1PCE A;  2DB6 A;  2UXB H;  4DV1 H;  1K7V A;  2A20 A;  1PTR A;  2CJS C;  2B8T A;  1OVO A;  2UXC H;  4OVO A;  4DR4 H;  3UEY A;  1N13 A;  1DS2 I;  3OVO A;  2ZM6 H;  4LF4 H;  1X74 A;  4X66 H;  4DR7 H;  1I6U A;  2JW6 A;  2OPV A;  3VDU A;  3KDG A;  2CTL A;  2SGF I;  3OXG A;  1J5E H;  3NCV A;  1HR0 H;  1SGN I;  1FY7 A;  4H8A A;  1UVG A;  2F4V H;  1WKX A;  4DV3 H;  3TO9 A;  4JI6 H;  2LB7 A;  4FKD A;  3TO6 A;  2B0U C;  3FC3 A;  1MT1 A;  1CE3 A;  2CPQ A;  4A24 A;  2CPM A;  1Z7K B;  2GKV A;  2P6A C;  2Y0M A;  2E73 A;  1CT2 I;  3R5D A;  3KY9 A;  2QQE A;  1EC6 A;  1TBN A;  2ELI A;  1P9Z A;  5CCL A;  2CTM A;  1M8C A;  1FJG H;  4DV5 H;  2CWG A;  5DAE A;  4B3R H;  2CWH A;  4LFA H;  3PDN A;  2CTE A;  1YTP A;  3HH2 C;  3J7A K;  4X65 H;  4PDB A;  5E3P A;  4HGU A;  3GAB A;  1XMO H;  4BA1 I;  3TO7 A;  3UEJ A;  2L7X A;  2JVZ A;  9WGA A;  1RFH A;  1SGP I;  2M5X A;  2MJH A;  2BL5 A;  4IFD G;  2SGD I;  2GKT I;  2JEB I;  4GKK H;  1HNZ H;  3GR5 A;  1NUB A;  2KMP A;  1AN1 I;  1SGY I;  1TOT A;  1KBE A;  1X4M A;  2D9I A;  2QQD A;  2LTM A;  2N71 A;  4DUZ H;  4AM3 A;  4B3M H;  1CGJ I;  2X06 A;  2NU2 I;  2KCX A;  2SGQ I;  2JYY A;  4AIM A;  1FAQ A;  2P2R A;  1W3S A;  4AML A;  4OCH A;  4DR1 H;  5IWA H;  4LF7 H;  1LR7 A;  1TUA A;  5CCM A;  1YU6 C;  3R5A A;  2ANR A;  1X0A A;  2F3C I;  2ERW A;  4FJU A;  2N1A B;  4DV2 H;  3T1Y H;  1X4N A;  4B8C D;  1CT4 I;  1NXU A;  1PQX A;  1TUS A;  1SGE I;  1V1H A;  1V9N A;  4BA2 I;  2ORV A;  1ZZK A;  2OD1 A;  4E1R A;  2LEO A;  4LFB H;  4YHH H;  1ZZJ A;  2M6Q A;  1VDD A;  1PTQ A;  2V1C C;  3GKU A;  4GKJ H;  2YQR A;  4LF6 H;  2JEA I;  3VE5 A;  1DT4 A;  4L9M A;  2UUA H;  5EX3 A;  2BUS A;  4MPI A;  1TGS I;  4LF5 H;  5JEA G;  4WAN A;  3RU0 A;  4B6D A;  4NZT M;  5FUV A;  2A1S A;  3AEV B;  3UOE A;  2CTF A;  2KMQ A;  3V69 A;  1N36 H;  4JI7 H;  5IT9 W;  2VQF H;  4NXN H;  2CTK A;  5A2Q W;  4JV5 H;  1MJA A;  4JVY A;  7WGA A;  2LUY A;  1N34 H;  1MSZ A;  4DV0 H;  4QMF B;  4B3T H;  2N17 A;  1K7U A;  2UXD H;  2WCY A;  1J4W A;  2LRR A;  1HPT A;  2UUC H;  1SGQ I;  1Y1B A;  3TJQ A;  5FUX A;  1CSO I;  2HH2 A;  5JHW C;  2JXD A;  4NXM H;  1V8C A;  1UG8 A;  2V53 A;  2X52 A;  2BA0 A;  2OU2 A;  2FMR A;  3OET A;  4JI8 H;  1N32 H;  5LMN H;  4UXI A;  3FSY A;  4JI4 H;  1W4R A;  4JVH A;  1X4S A;  3BJI A;  1F0X A;  1DTJ A;  3QD7 X;  1IBL H;  1SGR I;  2J9R A;  3I0P A;  2J87 A;  1ODH A;  2JA9 A;  3UGD A;  2VKC A;  2NN6 G;  4JI2 H;  3T1H H;  4K0K H;  2NU1 I;  2DKV A;  2E5R A;  2UUB H;  2ENN A;  1IY5 A;  2YQP A;  1KBF A;  5E3Q A;  1XA6 A;  1S20 A;  1V1I A;  1BUS A;  2ZQE A;  1S03 G;  3CXL A;  1ULN A;  1P9G A;  1PPF I;  3R5B A;  5J8F A;  1WGT A;  2JZM A;  4JI5 H;  2UZ3 A;  4LF9 H;  1N33 H;  4E1P A;  3J81 W;  1WE8 A;  2E5L H;  4DR6 H;  3UFF A;  5FUW A;  5LL6 b;  1K1G A;  4KHP H;  1SGD I;  1R0R I;  2HH3 A;  1HDL A;  2N52 A;  1Q9B A;  4X64 H;  1PJU A;  1CT0 I;  2W0T A;  3VDP A;  4AQY H;  2SGP I;  1CGI I;  2CTJ A;  5BR8 H;  4OO1 G;  3SGB I;  2FFM A;  2GIV A;  2OVO A;  1I94 H;  1XBT A;  5LMU H;  1H0Z A;  4JYA H;  1UHA A;  2LTL A;  3OXL A;  3UGI A;  2K9H A;  3OL0 A;  4X62 H;  1XRH A;  1OMU A;  2L8E A;  2O4C A;  2KMO A;  2E3U A;  4LIJ A;  4OD6 A;  1TUR A;  2V1C A;  1WTJ A;  1VBI A;  3J80 W;  4JCV E;  1ULM A;  2X3T A;  1TIH A;  1AN7 A;  4B3S H;  1OMT A;  1HEV A;  1IBM H;  2KMR A;  4JI1 H;  1MJ9 A;  3TOB A;  2QQC A;  4WP4 A;  1CHO I;  2Z0S A;  2PT7 G;  3MEK A;  5E3R A;  4DV6 H;  2JZX A;  3FAU A;  2JA1 A;  5FLX W;  1U5K A;  2QQ0 A;  1KMA A;  4NBQ A;  2AXY A;  4DR3 H;  1FKA H;  5EX0 A;  3QWP A;  3EZJ A;  2NU4 I;  2QPO A;  1ZTG A;  1IW4 A;  3OTO H; 
#chains in the Genus database with same CATH homology
 1XRH A;  1S20 A;  4FJS A;  4H8A A;  2CWH A;  4FJU A;  3I0P A;  2CWF A;  1Z2I A;  3UOE A;  1V9N A;  1NXU A;  1WTJ A;  2G8Y A;  2X06 A;  1X0A A;  1VBI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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