1SI2A

Crystal structure of the paz domain of human eif2c1 in complex with a 9-mer sirna-like duplex of deoxynucleotide overhang
Total Genus 28
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
126
structure length
120
Chain Sequence
MAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords 5'-R(*CP*GP*UP*GP*AP*CP*U)-D(P*CP*T)-3'
publication title Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Gene regulation/rna/dna
total genus 28
structure length 120
sequence length 126
ec nomenclature
pdb deposition date 2004-02-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02170 PAZ PAZ domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.260.10 Mainly Beta Beta Complex paz domain paz domain 1si2A00
3O3IX 4Z4FA 2L5CA 3QIRA 4W5RA 1SI2A 4KREA 4NHAA 2QVWA 2L5DA 1VYNA 3O7VX 4NGDA 4Z4CA 4Z4GA 4NGFA 4NH3A 2XFMA 4NH5A 4W5TA 5KI6A 4W5QA 3MJ0A 4NGGA 1SI3A 5JS1A 1R6ZA 1R4KA 4KRFA 3O6EX 4F3TA 4Z4IA 2FFLA 5T7BA 1T2SA 4OLAA 4NGCA 4OLBA 4NH6A 4Z4HA 4NGBA 1T2RA 3O7XA 5JS2A 4W5NA 4Z4EA 4W5OA
chains in the Genus database with same CATH superfamily
3O3IX 4Z4FA 2L5CA 3QIRA 4W5RA 1SI2A 4KREA 3DLBA 1Z26A 2QVWA 2L5DA 4NHAA 1VYNA 3DA5A 3O7VX 4NGDA 2DB9A 3HM9A 3DLHA 4Z4CA 3U1UA 4Z4GA 4NGFA 4NH3A 3HJFA 2BZEA 2XFMA 4NH5A 4W5TA 5KI6A 4W5QA 3MJ0A 4NGGA 1SI3A 3HK2A 3F73A 1R6ZA 1R4KA 5JS1A 4KRFA 3O6EX 4F3TA 4Z4IA 4L1UA 3HVRA 2FFLA 3HO1A 5T7BA 1T2SA 4L1PA 4OLAA 4NGCA 1Z25A 4OLBA 4NH6A 1U04A 4Z4HA 4NGBA 1T2RA 3O7XA 5JS2A 4W5NA 4Z4EA 4W5OA
chains in the Genus database with same CATH topology
3O3IX 4Z4FA 2L5CA 3QIRA 4W5RA 1SI2A 4KREA 3DLBA 1Z26A 2QVWA 2L5DA 4NHAA 1VYNA 3DA5A 3O7VX 4NGDA 2DB9A 3HM9A 3DLHA 4Z4CA 3U1UA 4Z4GA 4NGFA 4NH3A 3HJFA 2BZEA 2XFMA 4NH5A 4W5TA 5KI6A 4W5QA 3MJ0A 4NGGA 1SI3A 3HK2A 3F73A 1R6ZA 1R4KA 5JS1A 4KRFA 3O6EX 4F3TA 4Z4IA 4L1UA 3HVRA 2FFLA 3HO1A 5T7BA 1T2SA 4L1PA 4OLAA 4NGCA 1Z25A 4OLBA 4NH6A 1U04A 4Z4HA 4NGBA 1T2RA 3O7XA 5JS2A 4W5NA 4Z4EA 4W5OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3O3I X;  4Z4F A;  2L5C A;  3QIR A;  4W5R A;  1SI2 A;  4KRE A;  4NHA A;  2QVW A;  2L5D A;  1VYN A;  3O7V X;  4NGD A;  4Z4C A;  4Z4G A;  4NGF A;  4NH3 A;  2XFM A;  4NH5 A;  4W5T A;  5KI6 A;  4W5Q A;  3MJ0 A;  4NGG A;  1SI3 A;  5JS1 A;  1R6Z A;  1R4K A;  4KRF A;  3O6E X;  4F3T A;  4Z4I A;  2FFL A;  5T7B A;  1T2S A;  4OLA A;  4NGC A;  4OLB A;  4NH6 A;  4Z4H A;  4NGB A;  1T2R A;  3O7X A;  5JS2 A;  4W5N A;  4Z4E A;  4W5O A; 
#chains in the Genus database with same CATH topology
 3O3I X;  4Z4F A;  2L5C A;  3QIR A;  4W5R A;  1SI2 A;  4KRE A;  3DLB A;  1Z26 A;  2QVW A;  2L5D A;  4NHA A;  1VYN A;  3DA5 A;  3O7V X;  4NGD A;  2DB9 A;  3HM9 A;  3DLH A;  4Z4C A;  3U1U A;  4Z4G A;  4NGF A;  4NH3 A;  3HJF A;  2BZE A;  2XFM A;  4NH5 A;  4W5T A;  5KI6 A;  4W5Q A;  3MJ0 A;  4NGG A;  1SI3 A;  3HK2 A;  3F73 A;  1R6Z A;  1R4K A;  5JS1 A;  4KRF A;  3O6E X;  4F3T A;  4Z4I A;  4L1U A;  3HVR A;  2FFL A;  3HO1 A;  5T7B A;  1T2S A;  4L1P A;  4OLA A;  4NGC A;  1Z25 A;  4OLB A;  4NH6 A;  1U04 A;  4Z4H A;  4NGB A;  1T2R A;  3O7X A;  5JS2 A;  4W5N A;  4Z4E A;  4W5O A; 
#chains in the Genus database with same CATH homology
 3O3I X;  4Z4F A;  2L5C A;  3QIR A;  4W5R A;  1SI2 A;  4KRE A;  3DLB A;  1Z26 A;  2QVW A;  2L5D A;  4NHA A;  1VYN A;  3DA5 A;  3O7V X;  4NGD A;  2DB9 A;  3HM9 A;  3DLH A;  4Z4C A;  3U1U A;  4Z4G A;  4NGF A;  4NH3 A;  3HJF A;  2BZE A;  2XFM A;  4NH5 A;  4W5T A;  5KI6 A;  4W5Q A;  3MJ0 A;  4NGG A;  1SI3 A;  3HK2 A;  3F73 A;  1R6Z A;  1R4K A;  5JS1 A;  4KRF A;  3O6E X;  4F3T A;  4Z4I A;  4L1U A;  3HVR A;  2FFL A;  3HO1 A;  5T7B A;  1T2S A;  4L1P A;  4OLA A;  4NGC A;  1Z25 A;  4OLB A;  4NH6 A;  1U04 A;  4Z4H A;  4NGB A;  1T2R A;  3O7X A;  5JS2 A;  4W5N A;  4Z4E A;  4W5O A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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