1SJ8A

Crystal structure of talin residues 482-789
Total Genus 119
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
119
sequence length
297
structure length
297
Chain Sequence
PPLTSAQQALTGTINSSMQAVQAAQATLDDFETLPPLGQDAASKAWRKNKMDESKHEIHSQVDAITAGTASVVNLTAGDPAETDYTAVGCAVTTISSNLTEMSRGVKLLAALLEDEGGNGRPLLQAAKGLAGAVSELLRSAQPASAEPRQNLLQAAGNVGQASGELLQQIGESDTDPHFQDVLMQLANAVASAAAALVLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACTKVVAPTISSPVCQEQLVEAGRLVAKAVEGCVSASQAATEDGQLLRGVGAAATAVTQALNELL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle
pubmed doi rcsb
source organism Mus musculus
molecule tags Structural protein
molecule keywords Talin 1
total genus 119
structure length 297
sequence length 297
ec nomenclature
pdb deposition date 2004-03-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF09141 Talin_middle Talin, middle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1420.10 Mainly Alpha Up-down Bundle A middle domain of Talin 1 Talin, central domain 1sj8A01
1.20.1440.10 Mainly Alpha Up-down Bundle de novo design (two linked rop proteins) de novo design (two linked rop proteins) 1sj8A02
3DYJA 4W8PA 2KGXA 2L10A 3AY5A 2KVPA 1YO7A 2KBBA 1SJ8A 4F7GB 2X0CA 2L7NA 3FYQA 1SJ7A 5FZTA
chains in the Genus database with same CATH superfamily
3AJFA 2XQYA 1YO7A 3I9V1 3PF0A 4NV2A 4G75A 5JDFA 2FEFA 2F6MB 2FU2A 4G76A 2XTRA 3LJ0A 2A2CA 2LQUA 2P22B 4JCVE 5JDNA 2KGXA 4U6RA 1SJ8A 3WURA 2XTQA 4O1PA 4YZCA 1SJ7A 5FZTA 3DA3A 5HXEA 5HGIA 4YZ9A 2RIOA 2YFAA 5HXCA 3Q8DA 2RLDA 1TDPA 2YFBA 2ZRRA 2F66B 3IAM1 4ONRA 5HXHA 4Z7GA 5JDLA 2QZGA 3M1CA 4PL4A 3LJ2A 4I1TA 2CAZB 4AS2A 2L10A 2MJFB 4PL3A 2KKMA 2JB1A 4HFVA 4W8PA 3KP9A 2X0CA 3IAS1 4Q9VA 3P23A 5HWXA 2QSBA 2K19A 4Z7HA 2KVPA 3VA9A 2ETDA 2JBWA 5JDMA 2IP6A 2JAEA 2BL8A 2L1LB 2XMXA 3SDJA 2KBBA 3VJZA 5HWYA 3AT7A 1U5KA 5T1DA 3LJ1A 2E8GA 5HYAA 2BL7A 3AY5A 2QGMA 2A2DA 3PHF1 2JB3A 3WSCA 1W3SA 5JDGA 4AS3A 4OAUC 3DA4A 5HXRA 3DO9A 3FNBA 1JQOA 4ECGA 4DWLA 4HEA1 5LNK1 3UITA 2GSCA 3JSBA 4NV5A 2MTCA 5JDHA 5JDQA 3FVVA 4O1OA 4F7GB 5HXSA 2V1CC 3V5UA 3L0IA 3DYJA 4GXTA 4PL5A 2L7NA 3FYQA 2HGKA 4YZDA 2JB2A 2FUG1 2V6EA 3B55A 4OAVB 2RADA 3FBVA 2ZW3A 3V5SA 3F4MA 4BGOA
chains in the Genus database with same CATH topology
3AJFA 1YO7A 3I9V1 4NV2A 4G75A 2F6MB 4G76A 2XTRA 3LJ0A 2A2CA 2P22B 4JCVE 2KGXA 4U6RA 1SJ8A 2XTQA 4O1PA 4YZCA 1SJ7A 5FZTA 3DA3A 5HGIA 4YZ9A 2RIOA 2YFAA 3Q8DA 2YFBA 2ZRRA 2F66B 3IAM1 4Z7GA 4PL4A 3LJ2A 4I1TA 2CAZB 4AS2A 2L10A 2MJFB 4PL3A 2KKMA 2JB1A 4HFVA 4W8PA 3KP9A 2X0CA 3IAS1 4Q9VA 3P23A 2K19A 4Z7HA 2KVPA 3VA9A 2JAEA 2IP6A 2L1LB 2XMXA 3SDJA 2KBBA 1U5KA 3LJ1A 2E8GA 3AY5A 2A2DA 2JB3A 1W3SA 4AS3A 4OAUC 3DA4A 3DO9A 4DWLA 4HEA1 5LNK1 3UITA 3JSBA 4NV5A 4O1OA 4F7GB 2V1CC 3L0IA 3DYJA 4GXTA 4PL5A 2L7NA 3FYQA 4YZDA 2JB2A 2FUG1 2V6EA 4OAVB 3FBVA 3F4MA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3DYJ A;  4W8P A;  2KGX A;  2L10 A;  3AY5 A;  2KVP A;  1YO7 A;  2KBB A;  1SJ8 A;  4F7G B;  2X0C A;  2L7N A;  3FYQ A;  1SJ7 A;  5FZT A; 
#chains in the Genus database with same CATH topology
 3AJF A;  2XQY A;  1YO7 A;  3I9V 1;  3PF0 A;  4NV2 A;  4G75 A;  5JDF A;  2FEF A;  2F6M B;  2FU2 A;  4G76 A;  2XTR A;  3LJ0 A;  2A2C A;  2LQU A;  2P22 B;  4JCV E;  5JDN A;  2KGX A;  4U6R A;  1SJ8 A;  3WUR A;  2XTQ A;  4O1P A;  4YZC A;  1SJ7 A;  5FZT A;  3DA3 A;  5HXE A;  5HGI A;  4YZ9 A;  2RIO A;  2YFA A;  5HXC A;  3Q8D A;  2RLD A;  1TDP A;  2YFB A;  2ZRR A;  2F66 B;  3IAM 1;  4ONR A;  5HXH A;  4Z7G A;  5JDL A;  2QZG A;  3M1C A;  4PL4 A;  3LJ2 A;  4I1T A;  2CAZ B;  4AS2 A;  2L10 A;  2MJF B;  4PL3 A;  2KKM A;  2JB1 A;  4HFV A;  4W8P A;  3KP9 A;  2X0C A;  3IAS 1;  4Q9V A;  3P23 A;  5HWX A;  2QSB A;  2K19 A;  4Z7H A;  2KVP A;  3VA9 A;  2ETD A;  2JBW A;  5JDM A;  2IP6 A;  2JAE A;  2BL8 A;  2L1L B;  2XMX A;  3SDJ A;  2KBB A;  3VJZ A;  5HWY A;  3AT7 A;  1U5K A;  5T1D A;  3LJ1 A;  2E8G A;  5HYA A;  2BL7 A;  3AY5 A;  2QGM A;  2A2D A;  3PHF 1;  2JB3 A;  3WSC A;  1W3S A;  5JDG A;  4AS3 A;  4OAU C;  3DA4 A;  5HXR A;  3DO9 A;  3FNB A;  1JQO A;  4ECG A;  4DWL A;  4HEA 1;  5LNK 1;  3UIT A;  2GSC A;  3JSB A;  4NV5 A;  2MTC A;  5JDH A;  5JDQ A;  3FVV A;  4O1O A;  4F7G B;  5HXS A;  2V1C C;  3V5U A;  3L0I A;  3DYJ A;  4GXT A;  4PL5 A;  2L7N A;  3FYQ A;  2HGK A;  4YZD A;  2JB2 A;  2FUG 1;  2V6E A;  3B55 A;  4OAV B;  2RAD A;  3FBV A;  2ZW3 A;  3V5S A;  3F4M A;  4BGO A; 
#chains in the Genus database with same CATH homology
 3AJF A;  1YO7 A;  3I9V 1;  4NV2 A;  4G75 A;  2F6M B;  4G76 A;  2XTR A;  3LJ0 A;  2A2C A;  2P22 B;  4JCV E;  2KGX A;  4U6R A;  1SJ8 A;  2XTQ A;  4O1P A;  4YZC A;  1SJ7 A;  5FZT A;  3DA3 A;  5HGI A;  4YZ9 A;  2RIO A;  2YFA A;  3Q8D A;  2YFB A;  2ZRR A;  2F66 B;  3IAM 1;  4Z7G A;  4PL4 A;  3LJ2 A;  4I1T A;  2CAZ B;  4AS2 A;  2L10 A;  2MJF B;  4PL3 A;  2KKM A;  2JB1 A;  4HFV A;  4W8P A;  3KP9 A;  2X0C A;  3IAS 1;  4Q9V A;  3P23 A;  2K19 A;  4Z7H A;  2KVP A;  3VA9 A;  2JAE A;  2IP6 A;  2L1L B;  2XMX A;  3SDJ A;  2KBB A;  1U5K A;  3LJ1 A;  2E8G A;  3AY5 A;  2A2D A;  2JB3 A;  1W3S A;  4AS3 A;  4OAU C;  3DA4 A;  3DO9 A;  4DWL A;  4HEA 1;  5LNK 1;  3UIT A;  3JSB A;  4NV5 A;  4O1O A;  4F7G B;  2V1C C;  3L0I A;  3DYJ A;  4GXT A;  4PL5 A;  2L7N A;  3FYQ A;  4YZD A;  2JB2 A;  2FUG 1;  2V6E A;  4OAV B;  3FBV A;  3F4M A; 
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