1SJUA

Mini-proinsulin, single chain insulin analog mutant: des b30, his(b 10)asp, pro(b 28)asp and peptide bond between lys b 29 and gly a 1, nmr, 20 structures
Total Genus 5
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
5
sequence length
50
structure length
50
Chain Sequence
FVNQHLCGSDLVEALYLVCGERGFFYTDKGIVEQCCTSICSLYQLENYCN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hormone
molecule keywords PROINSULIN
publication title Mini-proinsulin and mini-IGF-I: homologous protein sequences encoding non-homologous structures.
pubmed doi rcsb
source organism Homo sapiens
total genus 5
structure length 50
sequence length 50
ec nomenclature
pdb deposition date 1997-10-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00049 Insulin Insulin/IGF/Relaxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.100.10 Mainly Alpha Orthogonal Bundle Insulin-like, subunit E Insulin-like 1sjuA00
4XSSB 2DSQC 2KJIA 2DSRI 1EFEA 1IGLA 1SJUA 1H59A 1GZYB 6INSE 1TGRA 1WQJI 1GZZB 1ZEIA 2DSPI 2GF1A 2L29B 2LWZA 1GZRB 3KR3D 3GF1A 1PMXA 5L3LA 1IMXA 2KQPA 3LRIA 5L3MA 1H02B 2JZQA 1B9GA 1BQTA 5L3NA
chains in the Genus database with same CATH superfamily
4XSSB 2DSQC 2KJIA 2DSRI 1EFEA 1IGLA 1SJUA 1H59A 1GZYB 2L14B 6INSE 1TGRA 1WQJI 1GZZB 1ZEIA 2DSPI 2GF1A 2L29B 2LWZA 1GZRB 3F2CA 3KR3D 3GF1A 1PMXA 3F2BA 5L3LA 1IMXA 2KQPA 3LRIA 5L3MA 1H02B 2JZQA 1B9GA 1BQTA 3F2DA 5L3NA
chains in the Genus database with same CATH topology
4XSSB 2DSQC 2KJIA 2DSRI 1EFEA 1IGLA 1SJUA 1H59A 1GZYB 6INSE 1TGRA 1WQJI 1GZZB 1ZEIA 2DSPI 2GF1A 2L29B 2LWZA 1GZRB 3KR3D 3GF1A 1PMXA 5L3LA 1IMXA 2KQPA 3LRIA 5L3MA 1H02B 2JZQA 1B9GA 1BQTA 5L3NA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4XSS B;  2DSQ C;  2KJI A;  2DSR I;  1EFE A;  1IGL A;  1SJU A;  1H59 A;  1GZY B;  6INS E;  1TGR A;  1WQJ I;  1GZZ B;  1ZEI A;  2DSP I;  2GF1 A;  2L29 B;  2LWZ A;  1GZR B;  3KR3 D;  3GF1 A;  1PMX A;  5L3L A;  1IMX A;  2KQP A;  3LRI A;  5L3M A;  1H02 B;  2JZQ A;  1B9G A;  1BQT A;  5L3N A; 
#chains in the Genus database with same CATH topology
 4XSS B;  2DSQ C;  2KJI A;  2DSR I;  1EFE A;  1IGL A;  1SJU A;  1H59 A;  1GZY B;  2L14 B;  6INS E;  1TGR A;  1WQJ I;  1GZZ B;  1ZEI A;  2DSP I;  2GF1 A;  2L29 B;  2LWZ A;  1GZR B;  3F2C A;  3KR3 D;  3GF1 A;  1PMX A;  3F2B A;  5L3L A;  1IMX A;  2KQP A;  3LRI A;  5L3M A;  1H02 B;  2JZQ A;  1B9G A;  1BQT A;  3F2D A;  5L3N A; 
#chains in the Genus database with same CATH homology
 4XSS B;  2DSQ C;  2KJI A;  2DSR I;  1EFE A;  1IGL A;  1SJU A;  1H59 A;  1GZY B;  6INS E;  1TGR A;  1WQJ I;  1GZZ B;  1ZEI A;  2DSP I;  2GF1 A;  2L29 B;  2LWZ A;  1GZR B;  3KR3 D;  3GF1 A;  1PMX A;  5L3L A;  1IMX A;  2KQP A;  3LRI A;  5L3M A;  1H02 B;  2JZQ A;  1B9G A;  1BQT A;  5L3N A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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