1T67A

Crystal structure of human hdac8 complexed with ms-344
Total Genus 127
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
127
sequence length
364
structure length
357
Chain Sequence
LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Histone deacetylase 8
publication title Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases
pubmed doi rcsb
source organism Homo sapiens
total genus 127
structure length 357
sequence length 364
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2004-05-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 1t67A00
5A2SA 3EZTA 5EF7A 2VQMA 5G0JA 5G1BA 3MZ4A 3EW8A 5LI3A 4CBYA 5EEKA 5ICNB 5THVA 1C3RA 1T67A 3SFFA 4QA3A 4CQFA 5G12A 1C3PA 4QA5A 5G13A 3EWFA 4QA7A 2V5WA 5D1BA 5DC7A 3F06A 4LY1A 5EEIA 4ZUOA 2VQWG 5D1DA 2VQVA 2VQQA 3Q9EA 3C10A 5EENA 5DC6A 3ZNRA 1T69A 5EFNA 5THTA 5EEMA 3MZ7A 3MZ6A 5EF8A 5G0YA 4BZ6A 4A69A 4RN1A 5IX0A 4QA0A 5G10A 5EEFA 5G0IA 3RQDA 2GH6A 4QA4A 1ZZ0A 1ZZ1A 5IWGA 3C0ZA 3C0YA 5FUEA 2V5XA 3MAXA 1C3SA 3Q9CA 4QA6A 5EFHA 4RN2A 5G0XA 5THSA 5THUA 3ZNSA 4ZUMA 4BZ8A 4ZUQA 5G1AA 4QA2A 5G0GA 4BZ5A 1W22A 4ZUPA 4ZURA 5BWZA 4QA1A 5EFBD 5DC8A 3F07A 5EFGA 5G17A 5G3WA 5D1CA 5G1CA 4LXZA 3Q9FA 5G0HA 3MZ3A 3MENA 4BKXB 2VCGA 5EFKB 4BZ7A 3Q9BA 3SFHA 5EFJD 5FCWA 3F0RA 1VKGA 5G11A 3EZPA 5DC5A 4BZ9A 4CBTA 1ZZ3A 2VQOA 2VQJA 4ZUNA 5JI5A 1T64A 4RN0A
chains in the Genus database with same CATH superfamily
2EIVA 5A2SA 3THJA 4GSZA 3THHA 1WVAA 2CEVA 3EZTA 4Q3RC 4Q40A 5EF7A 1RLAA 2ZAVA 2VQMA 5G0JA 4IU5A 5G1BA 3MZ4A 3MJLA 2EF4A 3EW8A 2PHAA 4GWCA 4IXUA 5LI3A 4CBYA 5EEKA 5ICNB 1D3VA 4Q3TA 5THVA 1P8OA 1C3RA 1T67A 4IE2A 4MYLA 3SFFA 4Q3UA 4Q3PA 4IU0A 4Q42A 4QA3A 3TF3A 1ZPEA 4Q3RA 4GSVA 1TBHA 1WOIA 5G12A 4CQFA 1T4SA 3GN0A 1C3PA 1HQXA 4FCKA 4IE1A 4QA5A 4GSMA 1T4RA 4FCIA 1WOHA 2AEBA 2PHOA 1T5GA 5G13A 4RLAA 3EWFA 4RHIA 1GQ7A 4QA7A 1P8SA 4HWWA 4MYKA 3MFVA 3F80A 3SL0A 2V5WA 5D1BA 5CEVA 5DC7A 3F06A 4LY1A 3SKKA 5EEIA 3E6KA 3LP4A 4ZUOA 2VQWG 3GMZA 4HZEA 3MMRA 5D1DA 4Q41A 1HQ5A 2VQVA 1HQHA 4RHJA 2VQQA 3Q9EA 4BZ7A 3C10A 3CEVA 5EENA 5DC6A 1P8NA 1R1OA 1T69A 5EFNA 3ZNRA 4IU4A 5THTA 5EEMA 4DZ4A 3MZ7A 4IXVA 5HJAA 3MZ6A 5EF8A 5G0YA 4BZ6A 2PLLA 1WVBA 3DJ8A 4RN1A 4A69A 4CEVA 5IX0A 4QA0A 4RHQA 1HQGA 5EEFA 5G10A 5G0IA 3RQDA 4MYFA 3TH7A 5RLAA 2GH6A 4Q3QA 4QA4A 1ZZ0A 1ZZ1A 1T5FA 1HQFA 4GWDA 3E6VA 5IWGA 4HXQA 3C0ZA 4MXRA 1ZPGA 1P8QA 3C0YA 5FUEA 2V5XA 2RLAA 3E8QA 3PZLA 1XFKA 3MAXA 1C3SA 4IE3A 3Q9CA 3LHLA 3E8ZA 4QA6A 1P8MA 4RHMA 2A0MA 5EFHA 4Q3SA 4RN2A 5G0XA 5THSA 5THUA 3ZNSA 4G3HA 4ZUMA 1TBLA 1T4PA 3NIOA 4BZ8A 4ZUQA 5G1AA 1P8RA 1GQ6A 4QA2A 4RHLA 5G0GA 5HJ9A 3THEA 4BZ5A 4I06A 1WOGA 1W22A 4ZUPA 4ZURA 3SJTA 3NIPA 5BWZA 4QA1A 5EFBD 5DC8A 3M1RA 3F07A 5EFGA 2EF5A 3E9BA 4RHKA 5G17A 4IU1A 1TBJA 5G3WA 5D1CA 1T4TA 4LXZA 3Q9FA 5G0HA 5G1CA 3MZ3A 3MENA 4BKXB 2VCGA 1CEVA 1PQ3A 1P8PA 3Q9BA 5EFKB 5EFJD 3SFHA 4Q3VA 3MFWA 5FCWA 3LP7A 3F0RA 4MYNA 1VKGA 1TA1A 3NIQA 5G11A 3EZPA 3SL1A 3KV2A 5DC5A 4BZ9A 4CBTA 3RLAA 1ZZ3A 2VQOA 2VQJA 4ITYA 4ZUNA 5JI5A 1T64A 4RN0A
chains in the Genus database with same CATH topology
5A2SA 3EZTA 5EF7A 2VQMA 5G0JA 5G1BA 3MZ4A 3EW8A 5LI3A 4CBYA 5EEKA 5ICNB 5THVA 1C3RA 1T67A 3SFFA 4QA3A 4CQFA 5G12A 1C3PA 4QA5A 5G13A 3EWFA 4QA7A 2V5WA 5D1BA 5DC7A 3F06A 4LY1A 5EEIA 4ZUOA 2VQWG 5D1DA 2VQVA 2VQQA 3Q9EA 3C10A 5EENA 5DC6A 3ZNRA 1T69A 5EFNA 5THTA 5EEMA 3MZ7A 3MZ6A 5EF8A 5G0YA 4BZ6A 4A69A 4RN1A 5IX0A 4QA0A 5G10A 5EEFA 5G0IA 3RQDA 2GH6A 4QA4A 1ZZ0A 1ZZ1A 5IWGA 3C0ZA 3C0YA 5FUEA 2V5XA 3MAXA 1C3SA 3Q9CA 4QA6A 5EFHA 4RN2A 5G0XA 5THSA 5THUA 3ZNSA 4ZUMA 4BZ8A 4ZUQA 5G1AA 4QA2A 5G0GA 4BZ5A 1W22A 4ZUPA 4ZURA 5BWZA 4QA1A 5EFBD 5DC8A 3F07A 5EFGA 5G17A 5G3WA 5D1CA 5G1CA 4LXZA 3Q9FA 5G0HA 3MZ3A 3MENA 4BKXB 2VCGA 5EFKB 4BZ7A 3Q9BA 3SFHA 5EFJD 5FCWA 3F0RA 1VKGA 5G11A 3EZPA 5DC5A 4BZ9A 4CBTA 1ZZ3A 2VQOA 2VQJA 4ZUNA 5JI5A 1T64A 4RN0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5A2S A;  3EZT A;  5EF7 A;  2VQM A;  5G0J A;  5G1B A;  3MZ4 A;  3EW8 A;  5LI3 A;  4CBY A;  5EEK A;  5ICN B;  5THV A;  1C3R A;  1T67 A;  3SFF A;  4QA3 A;  4CQF A;  5G12 A;  1C3P A;  4QA5 A;  5G13 A;  3EWF A;  4QA7 A;  2V5W A;  5D1B A;  5DC7 A;  3F06 A;  4LY1 A;  5EEI A;  4ZUO A;  2VQW G;  5D1D A;  2VQV A;  2VQQ A;  3Q9E A;  3C10 A;  5EEN A;  5DC6 A;  3ZNR A;  1T69 A;  5EFN A;  5THT A;  5EEM A;  3MZ7 A;  3MZ6 A;  5EF8 A;  5G0Y A;  4BZ6 A;  4A69 A;  4RN1 A;  5IX0 A;  4QA0 A;  5G10 A;  5EEF A;  5G0I A;  3RQD A;  2GH6 A;  4QA4 A;  1ZZ0 A;  1ZZ1 A;  5IWG A;  3C0Z A;  3C0Y A;  5FUE A;  2V5X A;  3MAX A;  1C3S A;  3Q9C A;  4QA6 A;  5EFH A;  4RN2 A;  5G0X A;  5THS A;  5THU A;  3ZNS A;  4ZUM A;  4BZ8 A;  4ZUQ A;  5G1A A;  4QA2 A;  5G0G A;  4BZ5 A;  1W22 A;  4ZUP A;  4ZUR A;  5BWZ A;  4QA1 A;  5EFB D;  5DC8 A;  3F07 A;  5EFG A;  5G17 A;  5G3W A;  5D1C A;  5G1C A;  4LXZ A;  3Q9F A;  5G0H A;  3MZ3 A;  3MEN A;  4BKX B;  2VCG A;  5EFK B;  4BZ7 A;  3Q9B A;  3SFH A;  5EFJ D;  5FCW A;  3F0R A;  1VKG A;  5G11 A;  3EZP A;  5DC5 A;  4BZ9 A;  4CBT A;  1ZZ3 A;  2VQO A;  2VQJ A;  4ZUN A;  5JI5 A;  1T64 A;  4RN0 A; 
#chains in the Genus database with same CATH topology
 2EIV A;  5A2S A;  3THJ A;  4GSZ A;  3THH A;  1WVA A;  2CEV A;  3EZT A;  4Q3R C;  4Q40 A;  5EF7 A;  1RLA A;  2ZAV A;  2VQM A;  5G0J A;  4IU5 A;  5G1B A;  3MZ4 A;  3MJL A;  2EF4 A;  3EW8 A;  2PHA A;  4GWC A;  4IXU A;  5LI3 A;  4CBY A;  5EEK A;  5ICN B;  1D3V A;  4Q3T A;  5THV A;  1P8O A;  1C3R A;  1T67 A;  4IE2 A;  4MYL A;  3SFF A;  4Q3U A;  4Q3P A;  4IU0 A;  4Q42 A;  4QA3 A;  3TF3 A;  1ZPE A;  4Q3R A;  4GSV A;  1TBH A;  1WOI A;  5G12 A;  4CQF A;  1T4S A;  3GN0 A;  1C3P A;  1HQX A;  4FCK A;  4IE1 A;  4QA5 A;  4GSM A;  1T4R A;  4FCI A;  1WOH A;  2AEB A;  2PHO A;  1T5G A;  5G13 A;  4RLA A;  3EWF A;  4RHI A;  1GQ7 A;  4QA7 A;  1P8S A;  4HWW A;  4MYK A;  3MFV A;  3F80 A;  3SL0 A;  2V5W A;  5D1B A;  5CEV A;  5DC7 A;  3F06 A;  4LY1 A;  3SKK A;  5EEI A;  3E6K A;  3LP4 A;  4ZUO A;  2VQW G;  3GMZ A;  4HZE A;  3MMR A;  5D1D A;  4Q41 A;  1HQ5 A;  2VQV A;  1HQH A;  4RHJ A;  2VQQ A;  3Q9E A;  4BZ7 A;  3C10 A;  3CEV A;  5EEN A;  5DC6 A;  1P8N A;  1R1O A;  1T69 A;  5EFN A;  3ZNR A;  4IU4 A;  5THT A;  5EEM A;  4DZ4 A;  3MZ7 A;  4IXV A;  5HJA A;  3MZ6 A;  5EF8 A;  5G0Y A;  4BZ6 A;  2PLL A;  1WVB A;  3DJ8 A;  4RN1 A;  4A69 A;  4CEV A;  5IX0 A;  4QA0 A;  4RHQ A;  1HQG A;  5EEF A;  5G10 A;  5G0I A;  3RQD A;  4MYF A;  3TH7 A;  5RLA A;  2GH6 A;  4Q3Q A;  4QA4 A;  1ZZ0 A;  1ZZ1 A;  1T5F A;  1HQF A;  4GWD A;  3E6V A;  5IWG A;  4HXQ A;  3C0Z A;  4MXR A;  1ZPG A;  1P8Q A;  3C0Y A;  5FUE A;  2V5X A;  2RLA A;  3E8Q A;  3PZL A;  1XFK A;  3MAX A;  1C3S A;  4IE3 A;  3Q9C A;  3LHL A;  3E8Z A;  4QA6 A;  1P8M A;  4RHM A;  2A0M A;  5EFH A;  4Q3S A;  4RN2 A;  5G0X A;  5THS A;  5THU A;  3ZNS A;  4G3H A;  4ZUM A;  1TBL A;  1T4P A;  3NIO A;  4BZ8 A;  4ZUQ A;  5G1A A;  1P8R A;  1GQ6 A;  4QA2 A;  4RHL A;  5G0G A;  5HJ9 A;  3THE A;  4BZ5 A;  4I06 A;  1WOG A;  1W22 A;  4ZUP A;  4ZUR A;  3SJT A;  3NIP A;  5BWZ A;  4QA1 A;  5EFB D;  5DC8 A;  3M1R A;  3F07 A;  5EFG A;  2EF5 A;  3E9B A;  4RHK A;  5G17 A;  4IU1 A;  1TBJ A;  5G3W A;  5D1C A;  1T4T A;  4LXZ A;  3Q9F A;  5G0H A;  5G1C A;  3MZ3 A;  3MEN A;  4BKX B;  2VCG A;  1CEV A;  1PQ3 A;  1P8P A;  3Q9B A;  5EFK B;  5EFJ D;  3SFH A;  4Q3V A;  3MFW A;  5FCW A;  3LP7 A;  3F0R A;  4MYN A;  1VKG A;  1TA1 A;  3NIQ A;  5G11 A;  3EZP A;  3SL1 A;  3KV2 A;  5DC5 A;  4BZ9 A;  4CBT A;  3RLA A;  1ZZ3 A;  2VQO A;  2VQJ A;  4ITY A;  4ZUN A;  5JI5 A;  1T64 A;  4RN0 A; 
#chains in the Genus database with same CATH homology
 5A2S A;  3EZT A;  5EF7 A;  2VQM A;  5G0J A;  5G1B A;  3MZ4 A;  3EW8 A;  5LI3 A;  4CBY A;  5EEK A;  5ICN B;  5THV A;  1C3R A;  1T67 A;  3SFF A;  4QA3 A;  4CQF A;  5G12 A;  1C3P A;  4QA5 A;  5G13 A;  3EWF A;  4QA7 A;  2V5W A;  5D1B A;  5DC7 A;  3F06 A;  4LY1 A;  5EEI A;  4ZUO A;  2VQW G;  5D1D A;  2VQV A;  2VQQ A;  3Q9E A;  3C10 A;  5EEN A;  5DC6 A;  3ZNR A;  1T69 A;  5EFN A;  5THT A;  5EEM A;  3MZ7 A;  3MZ6 A;  5EF8 A;  5G0Y A;  4BZ6 A;  4A69 A;  4RN1 A;  5IX0 A;  4QA0 A;  5G10 A;  5EEF A;  5G0I A;  3RQD A;  2GH6 A;  4QA4 A;  1ZZ0 A;  1ZZ1 A;  5IWG A;  3C0Z A;  3C0Y A;  5FUE A;  2V5X A;  3MAX A;  1C3S A;  3Q9C A;  4QA6 A;  5EFH A;  4RN2 A;  5G0X A;  5THS A;  5THU A;  3ZNS A;  4ZUM A;  4BZ8 A;  4ZUQ A;  5G1A A;  4QA2 A;  5G0G A;  4BZ5 A;  1W22 A;  4ZUP A;  4ZUR A;  5BWZ A;  4QA1 A;  5EFB D;  5DC8 A;  3F07 A;  5EFG A;  5G17 A;  5G3W A;  5D1C A;  5G1C A;  4LXZ A;  3Q9F A;  5G0H A;  3MZ3 A;  3MEN A;  4BKX B;  2VCG A;  5EFK B;  4BZ7 A;  3Q9B A;  3SFH A;  5EFJ D;  5FCW A;  3F0R A;  1VKG A;  5G11 A;  3EZP A;  5DC5 A;  4BZ9 A;  4CBT A;  1ZZ3 A;  2VQO A;  2VQJ A;  4ZUN A;  5JI5 A;  1T64 A;  4RN0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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