1T6PA

Crystal structure of phenylalanine ammonia lyase from rhodosporidium toruloides
Total Genus 228
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
228
sequence length
687
structure length
653
Chain Sequence
TNLAVAGSHLPTTQVTQVDIVEKMLAAPTDSTLELDGYSLNLGDVVSAARKGRPVRVKDSDEIRSKIDKSVEFLRSEDAISLQKALLEHQLCGVLPSSFDSFRLGRGLENSLPLEVVRGAMTIRVNSLTRGHSAVRLVVLEALTNFLNHGITPIVPLRGTISDLSPLSYIAAAISGHPDSKVHVVHEGKEKILYAREAMALFNLEPVVLGPKEGLGLVNGTAVSASMATLALHDAHMLSLLSQSLTAMTVEAMVGHAGSFHPFLHDVTRPHPTQIEVAGNIRKLLEGSRFAVHHEEQDRYPLRTSPQWLGPLVSDLIHAHAVLTIEAGQSTTDNPLIDVENKTSHHGGNFQAAAVANTMEKTRLGLAQIGKLNFTQLTEMLNAGMNRGLPSCLAAEDPSLSYHCKGLDIAAAAYTSELGHLANPVTTHVQPAEMANQAVNSLALISARRTTESNDVLSLLLATHLYCVLQAIDLRAIEFEFKKQFGPAIVSLIDQHFGSAMTGSNLRDELVEKVNKTLAKRLEQTNSYDLVPRWHDAFSFAAGTVVEVLSSTSLSLAAVNAWKVAAAESAISLTRQVRETFWSAASTSSPALSYLSPRTQILYAFVREELGVKARRGDVFLGKQEVTIGSNVSKIYEAIKSGRINNVLLKMLA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structure of phenylalanine ammonia lyase: multiple helix dipoles implicated in catalysis.
pubmed doi rcsb
source organism Rhodosporidium toruloides
molecule tags Lyase
molecule keywords phenylalanine ammonia-lyase
total genus 228
structure length 653
sequence length 687
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 4.3.1.25: Phenylalanine/tyrosine ammonia-lyase.
pdb deposition date 2004-05-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 1t6pA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1t6pA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1t6pA02
1HY1A 3OCFA 2J91A 4FLCA 5EYVA 1GKMA 3NO9A 2VD6A 4EEIA 3BHGA 4C6GA 2X75A 1FUPA 1TJVA 1C3CA 1U16A 1Q5NA 2O7DA 3E04A 3GTDA 3GZHA 5D6BA 1J3UA 2PFMA 1I0AA 2O7EA 4ADLA 2YIIA 3RRPA 4NSLA 1GKJA 1YFEA 2O7FA 5F91A 4CQ5A 2QVEA 2O6YA 1DOFA 1K62A 3KDYA 3OCEA 3UNVA 1VDKA 2O78A 4ADMA 5EYTA 1K7WA 2QGAB 1RE5A 4APAA 1FURA 1JSWA 1AUWA 1YISA 2PTQA 1TJ7A 1FUOA 4NLEA 4V2QA 4HGVA 1DCNA 2HVGA 5F92A 2NYFA 1GK2A 3RD8A 1FUQA 4APBA 2FUSA 4MX2A 4C5SA 1EB4A 4C5UA 3NZ4A 4BAAA 1HY0A 3R6YA 3CZOA 3KDZA 1TJWA 1YFMA 5HW2A 2PTSA 2RJSA 4BABA 3R6QA 4FFXA 2OHYA 2NYNA 1U15A 1Y2MA 2O7BA 2RJRA 1T6JA 1B8FA 3TV2A 4C5RA 1XWOA 3QBPA 4EFCA 1T6PA 1W27A 4V2RA 1KQ7A 3R6VA 3C8TA 2PTRA 1TJUA 2E9FA 1C3UA 1GK3A
chains in the Genus database with same CATH superfamily
1XL8A 1HY1A 3OCFA 2JA5A 2J91A 4FLCA 2A69D 4WNLA 5EYVA 1GKMA 3NO9A 2VD6A 4EEIA 3BHGA 1YNND 3U4QA 4C6GA 1R9TA 1XMDA 3GTLA 2O5JD 1EZBA 2X75A 1FUPA 1TJVA 1C3CA 4CEJA 1U16A 2X0PA 1Q5NA 2O7DA 3E04A 3GTDA 3CQZA 3GZHA 5D6BA 1J3UA 2PFMA 2YU9A 1I0AA 2MP0A 2NVXA 2O7EA 1Y1WA 2N1DB 2NVYA 4ADLA 2YIIA 4FBSA 3RRPA 3H0GA 4NSLA 1GKJA 1YFEA 2VL7A 2O7FA 2FIOA 1IW7D 5F91A 4CQ5A 2BE5D 3GTOA 2QVEA 1XMCA 4C2MA 2O6YA 2FIPA 3LRDA 1DOFA 1K62A 3KDYA 3OCEA 3UNVA 2HROA 2LPJA 2R93A 1VDKA 5M0IA 1K83A 2E2HA 2O78A 4ADMA 3FKIA 2A6ED 2K3QA 2VUMA 5EYTA 1K7WA 2FELA 2A6HD 1I6VD 2AQLA 2LYIA 2N3EA 2JA7A 2QGAB 1ZYMA 1HQMD 3EZAA 1FURA 1JSWA 1RE5A 4APAA 1AUWA 2X0QA 2MX9A 1YISA 2Y0NA 2PTQA 2LKMB 1TJ7A 1Y1VA 1YNJD 3LR6A 1FUOA 1SMYD 1EZAA 1I50A 4NLEA 2VSFA 3EZBA 2R92A 2MX8A 4V2QA 4QIWA 2JA6A 3GTPA 2A68D 1XL7A 1DCNA 3CRVA 3GTJA 3GTMA 4HGVA 1TWAA 1XLYA 2F5JA 2HVGA 1TWFA 5F92A 3EZEA 2NYFA 2R7ZA 1GK2A 5H8WA 3RD8A 1FUQA 4APBA 3LR2A 2FUSA 2K3NA 4MX2A 4C5SA 1EB4A 2E2IA 4C5UA 4A15A 3NZ4A 4BAAA 1HY0A 3R6YA 4CEIA 3CZOA 3KDZA 1TJWA 1YFMA 5HW2A 3GTKA 1I3QA 2PTSA 1TWCA 2RJSA 4BABA 3LR8A 2X0OA 3R6QA 2MQAA 5M0JA 2HWGA 5IZ2A 4FFXA 1WCMA 1ZYRD 2VK9A 2OHYA 2NYNA 1U15A 2LPIA 1Y2MA 2O7BA 2RJRA 2K3OA 1T6JA 3U44A 2EZCA 1B8FA 2LTHA 3TV2A 1TWHA 3CRW1 2FENA 2EZAA 4C5RA 4CEHA 2CW0D 1XWOA 3QBPA 4EFCA 4V2RA 1SFOA 1T6PA 1W27A 1TWGA 3GTQA 2B63A 1KQ7A 3R6VA 2EZBA 3C8TA 3GTGA 2PTRA 1TJUA 2E9FA 1C3UA 1GK3A
chains in the Genus database with same CATH topology
1HY1A 3OCFA 2J91A 4FLCA 5EYVA 1GKMA 3NO9A 2VD6A 4EEIA 3BHGA 4C6GA 2X75A 1FUPA 1TJVA 1C3CA 1U16A 1Q5NA 2O7DA 3E04A 3GTDA 3GZHA 5D6BA 1J3UA 2PFMA 1I0AA 2O7EA 4ADLA 2YIIA 3RRPA 4NSLA 1GKJA 1YFEA 2O7FA 5F91A 4CQ5A 2QVEA 2O6YA 1DOFA 1K62A 3KDYA 3OCEA 3UNVA 1VDKA 2O78A 4ADMA 5EYTA 1K7WA 2QGAB 1RE5A 4APAA 1FURA 1JSWA 1AUWA 1YISA 2PTQA 1TJ7A 1FUOA 4NLEA 4V2QA 4HGVA 1DCNA 2HVGA 5F92A 2NYFA 1GK2A 3RD8A 1FUQA 4APBA 2FUSA 4MX2A 4C5SA 1EB4A 4C5UA 3NZ4A 4BAAA 1HY0A 3R6YA 3CZOA 3KDZA 1TJWA 1YFMA 5HW2A 2PTSA 2RJSA 4BABA 3R6QA 4FFXA 2OHYA 2NYNA 1U15A 1Y2MA 2O7BA 2RJRA 1T6JA 1B8FA 3TV2A 4C5RA 1XWOA 3QBPA 4EFCA 1T6PA 1W27A 4V2RA 1KQ7A 3R6VA 3C8TA 2PTRA 1TJUA 2E9FA 1C3UA 1GK3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1HY1 A;  3OCF A;  2J91 A;  4FLC A;  5EYV A;  1GKM A;  3NO9 A;  2VD6 A;  4EEI A;  3BHG A;  4C6G A;  2X75 A;  1FUP A;  1TJV A;  1C3C A;  1U16 A;  1Q5N A;  2O7D A;  3E04 A;  3GTD A;  3GZH A;  5D6B A;  1J3U A;  2PFM A;  1I0A A;  2O7E A;  4ADL A;  2YII A;  3RRP A;  4NSL A;  1GKJ A;  1YFE A;  2O7F A;  5F91 A;  4CQ5 A;  2QVE A;  2O6Y A;  1DOF A;  1K62 A;  3KDY A;  3OCE A;  3UNV A;  1VDK A;  2O78 A;  4ADM A;  5EYT A;  1K7W A;  2QGA B;  1RE5 A;  4APA A;  1FUR A;  1JSW A;  1AUW A;  1YIS A;  2PTQ A;  1TJ7 A;  1FUO A;  4NLE A;  4V2Q A;  4HGV A;  1DCN A;  2HVG A;  5F92 A;  2NYF A;  1GK2 A;  3RD8 A;  1FUQ A;  4APB A;  2FUS A;  4MX2 A;  4C5S A;  1EB4 A;  4C5U A;  3NZ4 A;  4BAA A;  1HY0 A;  3R6Y A;  3CZO A;  3KDZ A;  1TJW A;  1YFM A;  5HW2 A;  2PTS A;  2RJS A;  4BAB A;  3R6Q A;  4FFX A;  2OHY A;  2NYN A;  1U15 A;  1Y2M A;  2O7B A;  2RJR A;  1T6J A;  1B8F A;  3TV2 A;  4C5R A;  1XWO A;  3QBP A;  4EFC A;  1T6P A;  1W27 A;  4V2R A;  1KQ7 A;  3R6V A;  3C8T A;  2PTR A;  1TJU A;  2E9F A;  1C3U A;  1GK3 A; 
#chains in the Genus database with same CATH topology
 1XL8 A;  1HY1 A;  3OCF A;  2JA5 A;  2J91 A;  4FLC A;  2A69 D;  4WNL A;  5EYV A;  1GKM A;  3NO9 A;  2VD6 A;  4EEI A;  3BHG A;  1YNN D;  3U4Q A;  4C6G A;  1R9T A;  1XMD A;  3GTL A;  2O5J D;  1EZB A;  2X75 A;  1FUP A;  1TJV A;  1C3C A;  4CEJ A;  1U16 A;  2X0P A;  1Q5N A;  2O7D A;  3E04 A;  3GTD A;  3CQZ A;  3GZH A;  5D6B A;  1J3U A;  2PFM A;  2YU9 A;  1I0A A;  2MP0 A;  2NVX A;  2O7E A;  1Y1W A;  2N1D B;  2NVY A;  4ADL A;  2YII A;  4FBS A;  3RRP A;  3H0G A;  4NSL A;  1GKJ A;  1YFE A;  2VL7 A;  2O7F A;  2FIO A;  1IW7 D;  5F91 A;  4CQ5 A;  2BE5 D;  3GTO A;  2QVE A;  1XMC A;  4C2M A;  2O6Y A;  2FIP A;  3LRD A;  1DOF A;  1K62 A;  3KDY A;  3OCE A;  3UNV A;  2HRO A;  2LPJ A;  2R93 A;  1VDK A;  5M0I A;  1K83 A;  2E2H A;  2O78 A;  4ADM A;  3FKI A;  2A6E D;  2K3Q A;  2VUM A;  5EYT A;  1K7W A;  2FEL A;  2A6H D;  1I6V D;  2AQL A;  2LYI A;  2N3E A;  2JA7 A;  2QGA B;  1ZYM A;  1HQM D;  3EZA A;  1FUR A;  1JSW A;  1RE5 A;  4APA A;  1AUW A;  2X0Q A;  2MX9 A;  1YIS A;  2Y0N A;  2PTQ A;  2LKM B;  1TJ7 A;  1Y1V A;  1YNJ D;  3LR6 A;  1FUO A;  1SMY D;  1EZA A;  1I50 A;  4NLE A;  2VSF A;  3EZB A;  2R92 A;  2MX8 A;  4V2Q A;  4QIW A;  2JA6 A;  3GTP A;  2A68 D;  1XL7 A;  1DCN A;  3CRV A;  3GTJ A;  3GTM A;  4HGV A;  1TWA A;  1XLY A;  2F5J A;  2HVG A;  1TWF A;  5F92 A;  3EZE A;  2NYF A;  2R7Z A;  1GK2 A;  5H8W A;  3RD8 A;  1FUQ A;  4APB A;  3LR2 A;  2FUS A;  2K3N A;  4MX2 A;  4C5S A;  1EB4 A;  2E2I A;  4C5U A;  4A15 A;  3NZ4 A;  4BAA A;  1HY0 A;  3R6Y A;  4CEI A;  3CZO A;  3KDZ A;  1TJW A;  1YFM A;  5HW2 A;  3GTK A;  1I3Q A;  2PTS A;  1TWC A;  2RJS A;  4BAB A;  3LR8 A;  2X0O A;  3R6Q A;  2MQA A;  5M0J A;  2HWG A;  5IZ2 A;  4FFX A;  1WCM A;  1ZYR D;  2VK9 A;  2OHY A;  2NYN A;  1U15 A;  2LPI A;  1Y2M A;  2O7B A;  2RJR A;  2K3O A;  1T6J A;  3U44 A;  2EZC A;  1B8F A;  2LTH A;  3TV2 A;  1TWH A;  3CRW 1;  2FEN A;  2EZA A;  4C5R A;  4CEH A;  2CW0 D;  1XWO A;  3QBP A;  4EFC A;  4V2R A;  1SFO A;  1T6P A;  1W27 A;  1TWG A;  3GTQ A;  2B63 A;  1KQ7 A;  3R6V A;  2EZB A;  3C8T A;  3GTG A;  2PTR A;  1TJU A;  2E9F A;  1C3U A;  1GK3 A; 
#chains in the Genus database with same CATH homology
 1HY1 A;  3OCF A;  2J91 A;  4FLC A;  5EYV A;  1GKM A;  3NO9 A;  2VD6 A;  4EEI A;  3BHG A;  4C6G A;  2X75 A;  1FUP A;  1TJV A;  1C3C A;  1U16 A;  1Q5N A;  2O7D A;  3E04 A;  3GTD A;  3GZH A;  5D6B A;  1J3U A;  2PFM A;  1I0A A;  2O7E A;  4ADL A;  2YII A;  3RRP A;  4NSL A;  1GKJ A;  1YFE A;  2O7F A;  5F91 A;  4CQ5 A;  2QVE A;  2O6Y A;  1DOF A;  1K62 A;  3KDY A;  3OCE A;  3UNV A;  1VDK A;  2O78 A;  4ADM A;  5EYT A;  1K7W A;  2QGA B;  1RE5 A;  4APA A;  1FUR A;  1JSW A;  1AUW A;  1YIS A;  2PTQ A;  1TJ7 A;  1FUO A;  4NLE A;  4V2Q A;  4HGV A;  1DCN A;  2HVG A;  5F92 A;  2NYF A;  1GK2 A;  3RD8 A;  1FUQ A;  4APB A;  2FUS A;  4MX2 A;  4C5S A;  1EB4 A;  4C5U A;  3NZ4 A;  4BAA A;  1HY0 A;  3R6Y A;  3CZO A;  3KDZ A;  1TJW A;  1YFM A;  5HW2 A;  2PTS A;  2RJS A;  4BAB A;  3R6Q A;  4FFX A;  2OHY A;  2NYN A;  1U15 A;  1Y2M A;  2O7B A;  2RJR A;  1T6J A;  1B8F A;  3TV2 A;  4C5R A;  1XWO A;  3QBP A;  4EFC A;  1T6P A;  1W27 A;  4V2R A;  1KQ7 A;  3R6V A;  3C8T A;  2PTR A;  1TJU A;  2E9F A;  1C3U A;  1GK3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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