1T6PA

Crystal structure of phenylalanine ammonia lyase from rhodosporidium toruloides
Total Genus 228
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
228
sequence length
687
structure length
653
Chain Sequence
b'TNLAVAGSHLPTTQVTQVDIVEKMLAAPTDSTLELDGYSLNLGDVVSAARKGRPVRVKDSDEIRSKIDKSVEFLRSEDAISLQKALLEHQLCGVLPSSFDSFRLGRGLENSLPLEVVRGAMTIRVNSLTRGHSAVRLVVLEALTNFLNHGITPIVPLRGTISDLSPLSYIAAAISGHPDSKVHVVHEGKEKILYAREAMALFNLEPVVLGPKEGLGLVNGTAVSASMATLALHDAHMLSLLSQSLTAMTVEAMVGHAGSFHPFLHDVTRPHPTQIEVAGNIRKLLEGSRFAVHHEEQDRYPLRTSPQWLGPLVSDLIHAHAVLTIEAGQSTTDNPLIDVENKTSHHGGNFQAAAVANTMEKTRLGLAQIGKLNFTQLTEMLNAGMNRGLPSCLAAEDPSLSYHCKGLDIAAAAYTSELGHLANPVTTHVQPAEMANQAVNSLALISARRTTESNDVLSLLLATHLYCVLQAIDLRAIEFEFKKQFGPAIVSLIDQHFGSAMTGSNLRDELVEKVNKTLAKRLEQTNSYDLVPRWHDAFSFAAGTVVEVLSSTSLSLAAVNAWKVAAAESAISLTRQVRETFWSAASTSSPALSYLSPRTQILYAFVREELGVKARRGDVFLGKQEVTIGSNVSKIYEAIKSGRINNVLLKMLA'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords phenylalanine ammonia-lyase
publication title Crystal structure of phenylalanine ammonia lyase: multiple helix dipoles implicated in catalysis.
pubmed doi rcsb
source organism Rhodosporidium toruloides
molecule tags Lyase
total genus 228
structure length 653
sequence length 687
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 4.3.1.25: Phenylalanine/tyrosine ammonia-lyase.
pdb deposition date 2004-05-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 1t6pA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1t6pA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1t6pA02
1KQ7A 3NZ4A 4CQ5A 1K7WA 2O7FA 1DCNA 1FUQA 1C3CA 3GTDA 1YFEA 1B8FA 2HVGA 5EYTA 3UNVA 5EYVA 3R6QA 1Y2MA 3NO9A 2O7EA 5HW2A 1YFMA 1TJ7A 3QBPA 2NYNA 1Q5NA 4C5SA 1I0AA 3KDYA 4C5RA 1K62A 2VD6A 4V2RA 3GZHA 4BAAA 2PTQA 1HY1A 4NSLA 1T6PA 1RE5A 3R6VA 1U15A 2O7BA 2E9FA 2QVEA 4FLCA 2PTSA 4APAA 2FUSA 3BHGA 1TJUA 2PFMA 4HGVA 1GK2A 2O7DA 1T6JA 1J3UA 1GK3A 5F92A 1YISA 1U16A 2OHYA 1C3UA 4C5UA 4APBA 3OCFA 1TJWA 1TJVA 4C6GA 4ADLA 4EFCA 1AUWA 2PTRA 1GKMA 3C8TA 1JSWA 2QGAB 3TV2A 1XWOA 2RJRA 3CZOA 1W27A 4EEIA 2O6YA 4V2QA 1GKJA 4ADMA 4FFXA 4NLEA 2YIIA 3RD8A 3E04A 3R6YA 1HY0A 2J91A 5F91A 4MX2A 3RRPA 3KDZA 4BABA 1VDKA 2X75A 2NYFA 1FUPA 2O78A 1FURA 5D6BA 1EB4A 2RJSA 1FUOA 1DOFA 3OCEA
chains in the Genus database with same CATH superfamily
1SMYD 2FELA 3GTKA 1ZYMA 1KQ7A 3NZ4A 4CQ5A 1K7WA 2EZBA 2O7FA 2FENA 1DCNA 2K3OA 1FUQA 1C3CA 3GTDA 2LYIA 1XL8A 1TWFA 1YNJD 1YFEA 2B63A 2NVXA 1B8FA 1TWHA 2F5JA 3EZAA 2HVGA 5EYTA 2JA6A 1I6VD 2A68D 3UNVA 5EYVA 3R6QA 1Y2MA 3NO9A 5M0JA 3LR6A 2X0PA 2O7EA 5HW2A 1YFMA 2LTHA 1TJ7A 3QBPA 2NYNA 1Q5NA 1I3QA 4C5SA 1I0AA 2X0OA 2CW0D 3GTOA 3KDYA 4C5RA 1K62A 2VD6A 4C2MA 2MX9A 4V2RA 1EZAA 2YU9A 4FBSA 3GZHA 1YNND 4BAAA 2BE5D 3GTLA 2PTQA 2JA5A 1Y1VA 1HY1A 4NSLA 1T6PA 4CEIA 2EZCA 1RE5A 1I50A 2FIPA 3R6VA 1U15A 3GTGA 1K83A 2HWGA 2O7BA 2LPJA 2R7ZA 2MP0A 2E9FA 1TWGA 2QVEA 4FLCA 2PTSA 2N3EA 2R92A 4APAA 2FUSA 2O5JD 2E2HA 1SFOA 3BHGA 1TJUA 2PFMA 1Y1WA 3GTQA 4HGVA 2X0QA 1GK2A 3LRDA 1XL7A 2O7DA 1T6JA 2Y0NA 2R93A 1TWCA 1J3UA 1GK3A 3EZBA 5F92A 2LPIA 1YISA 5M0IA 2MX8A 3LR8A 4CEHA 1U16A 2OHYA 5IZ2A 1C3UA 2K3QA 4C5UA 4APBA 4CEJA 3OCFA 1TJWA 3OCEA 2A6ED 3FKIA 1TJVA 5H8WA 4C6GA 3CQZA 4ADLA 4EFCA 3CRW1 2N1DB 1AUWA 2PTRA 2LKMB 1GKMA 3H0GA 3C8TA 1XMDA 1JSWA 2QGAB 3TV2A 1XWOA 2RJRA 3CZOA 2AQLA 1WCMA 1XLYA 1R9TA 1W27A 2K3NA 4EEIA 4A15A 2O6YA 2VL7A 4V2QA 1GKJA 4ADMA 4FFXA 4NLEA 4WNLA 2HROA 2YIIA 1HQMD 2A69D 3LR2A 4QIWA 2VK9A 3GTPA 3CRVA 3E04A 2E2IA 3R6YA 3RD8A 1HY0A 2J91A 5F91A 4MX2A 3RRPA 3KDZA 3GTJA 4BABA 2VSFA 1ZYRD 1VDKA 2X75A 2MQAA 2A6HD 2JA7A 2NYFA 1FUPA 1EZBA 3U4QA 2FIOA 2VUMA 1FURA 2O78A 1IW7D 2EZAA 5D6BA 1EB4A 3U44A 2RJSA 1XMCA 1TWAA 1FUOA 1DOFA 3EZEA 3GTMA 2NVYA
chains in the Genus database with same CATH topology
1KQ7A 3NZ4A 4CQ5A 1K7WA 2O7FA 1DCNA 1FUQA 1C3CA 3GTDA 1YFEA 1B8FA 2HVGA 5EYTA 3UNVA 5EYVA 3R6QA 1Y2MA 3NO9A 2O7EA 5HW2A 1YFMA 1TJ7A 3QBPA 2NYNA 1Q5NA 4C5SA 1I0AA 3KDYA 4C5RA 1K62A 2VD6A 4V2RA 3GZHA 4BAAA 2PTQA 1HY1A 4NSLA 1T6PA 1RE5A 3R6VA 1U15A 2O7BA 2E9FA 2QVEA 4FLCA 2PTSA 4APAA 2FUSA 3BHGA 1TJUA 2PFMA 4HGVA 1GK2A 2O7DA 1T6JA 1J3UA 1GK3A 5F92A 1YISA 1U16A 2OHYA 1C3UA 4C5UA 4APBA 3OCFA 1TJWA 1TJVA 4C6GA 4ADLA 4EFCA 1AUWA 2PTRA 1GKMA 3C8TA 1JSWA 2QGAB 3TV2A 1XWOA 2RJRA 3CZOA 1W27A 4EEIA 2O6YA 4V2QA 1GKJA 4ADMA 4FFXA 4NLEA 2YIIA 3RD8A 3E04A 3R6YA 1HY0A 2J91A 5F91A 4MX2A 3RRPA 3KDZA 4BABA 1VDKA 2X75A 2NYFA 1FUPA 2O78A 1FURA 5D6BA 1EB4A 2RJSA 1FUOA 1DOFA 3OCEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KQ7 A;  3NZ4 A;  4CQ5 A;  1K7W A;  2O7F A;  1DCN A;  1FUQ A;  1C3C A;  3GTD A;  1YFE A;  1B8F A;  2HVG A;  5EYT A;  3UNV A;  5EYV A;  3R6Q A;  1Y2M A;  3NO9 A;  2O7E A;  5HW2 A;  1YFM A;  1TJ7 A;  3QBP A;  2NYN A;  1Q5N A;  4C5S A;  1I0A A;  3KDY A;  4C5R A;  1K62 A;  2VD6 A;  4V2R A;  3GZH A;  4BAA A;  2PTQ A;  1HY1 A;  4NSL A;  1T6P A;  1RE5 A;  3R6V A;  1U15 A;  2O7B A;  2E9F A;  2QVE A;  4FLC A;  2PTS A;  4APA A;  2FUS A;  3BHG A;  1TJU A;  2PFM A;  4HGV A;  1GK2 A;  2O7D A;  1T6J A;  1J3U A;  1GK3 A;  5F92 A;  1YIS A;  1U16 A;  2OHY A;  1C3U A;  4C5U A;  4APB A;  3OCF A;  1TJW A;  1TJV A;  4C6G A;  4ADL A;  4EFC A;  1AUW A;  2PTR A;  1GKM A;  3C8T A;  1JSW A;  2QGA B;  3TV2 A;  1XWO A;  2RJR A;  3CZO A;  1W27 A;  4EEI A;  2O6Y A;  4V2Q A;  1GKJ A;  4ADM A;  4FFX A;  4NLE A;  2YII A;  3RD8 A;  3E04 A;  3R6Y A;  1HY0 A;  2J91 A;  5F91 A;  4MX2 A;  3RRP A;  3KDZ A;  4BAB A;  1VDK A;  2X75 A;  2NYF A;  1FUP A;  2O78 A;  1FUR A;  5D6B A;  1EB4 A;  2RJS A;  1FUO A;  1DOF A;  3OCE A; 
#chains in the Genus database with same CATH topology
 1SMY D;  2FEL A;  3GTK A;  1ZYM A;  1KQ7 A;  3NZ4 A;  4CQ5 A;  1K7W A;  2EZB A;  2O7F A;  2FEN A;  1DCN A;  2K3O A;  1FUQ A;  1C3C A;  3GTD A;  2LYI A;  1XL8 A;  1TWF A;  1YNJ D;  1YFE A;  2B63 A;  2NVX A;  1B8F A;  1TWH A;  2F5J A;  3EZA A;  2HVG A;  5EYT A;  2JA6 A;  1I6V D;  2A68 D;  3UNV A;  5EYV A;  3R6Q A;  1Y2M A;  3NO9 A;  5M0J A;  3LR6 A;  2X0P A;  2O7E A;  5HW2 A;  1YFM A;  2LTH A;  1TJ7 A;  3QBP A;  2NYN A;  1Q5N A;  1I3Q A;  4C5S A;  1I0A A;  2X0O A;  2CW0 D;  3GTO A;  3KDY A;  4C5R A;  1K62 A;  2VD6 A;  4C2M A;  2MX9 A;  4V2R A;  1EZA A;  2YU9 A;  4FBS A;  3GZH A;  1YNN D;  4BAA A;  2BE5 D;  3GTL A;  2PTQ A;  2JA5 A;  1Y1V A;  1HY1 A;  4NSL A;  1T6P A;  4CEI A;  2EZC A;  1RE5 A;  1I50 A;  2FIP A;  3R6V A;  1U15 A;  3GTG A;  1K83 A;  2HWG A;  2O7B A;  2LPJ A;  2R7Z A;  2MP0 A;  2E9F A;  1TWG A;  2QVE A;  4FLC A;  2PTS A;  2N3E A;  2R92 A;  4APA A;  2FUS A;  2O5J D;  2E2H A;  1SFO A;  3BHG A;  1TJU A;  2PFM A;  1Y1W A;  3GTQ A;  4HGV A;  2X0Q A;  1GK2 A;  3LRD A;  1XL7 A;  2O7D A;  1T6J A;  2Y0N A;  2R93 A;  1TWC A;  1J3U A;  1GK3 A;  3EZB A;  5F92 A;  2LPI A;  1YIS A;  5M0I A;  2MX8 A;  3LR8 A;  4CEH A;  1U16 A;  2OHY A;  5IZ2 A;  1C3U A;  2K3Q A;  4C5U A;  4APB A;  4CEJ A;  3OCF A;  1TJW A;  3OCE A;  2A6E D;  3FKI A;  1TJV A;  5H8W A;  4C6G A;  3CQZ A;  4ADL A;  4EFC A;  3CRW 1;  2N1D B;  1AUW A;  2PTR A;  2LKM B;  1GKM A;  3H0G A;  3C8T A;  1XMD A;  1JSW A;  2QGA B;  3TV2 A;  1XWO A;  2RJR A;  3CZO A;  2AQL A;  1WCM A;  1XLY A;  1R9T A;  1W27 A;  2K3N A;  4EEI A;  4A15 A;  2O6Y A;  2VL7 A;  4V2Q A;  1GKJ A;  4ADM A;  4FFX A;  4NLE A;  4WNL A;  2HRO A;  2YII A;  1HQM D;  2A69 D;  3LR2 A;  4QIW A;  2VK9 A;  3GTP A;  3CRV A;  3E04 A;  2E2I A;  3R6Y A;  3RD8 A;  1HY0 A;  2J91 A;  5F91 A;  4MX2 A;  3RRP A;  3KDZ A;  3GTJ A;  4BAB A;  2VSF A;  1ZYR D;  1VDK A;  2X75 A;  2MQA A;  2A6H D;  2JA7 A;  2NYF A;  1FUP A;  1EZB A;  3U4Q A;  2FIO A;  2VUM A;  1FUR A;  2O78 A;  1IW7 D;  2EZA A;  5D6B A;  1EB4 A;  3U44 A;  2RJS A;  1XMC A;  1TWA A;  1FUO A;  1DOF A;  3EZE A;  3GTM A;  2NVY A; 
#chains in the Genus database with same CATH homology
 1KQ7 A;  3NZ4 A;  4CQ5 A;  1K7W A;  2O7F A;  1DCN A;  1FUQ A;  1C3C A;  3GTD A;  1YFE A;  1B8F A;  2HVG A;  5EYT A;  3UNV A;  5EYV A;  3R6Q A;  1Y2M A;  3NO9 A;  2O7E A;  5HW2 A;  1YFM A;  1TJ7 A;  3QBP A;  2NYN A;  1Q5N A;  4C5S A;  1I0A A;  3KDY A;  4C5R A;  1K62 A;  2VD6 A;  4V2R A;  3GZH A;  4BAA A;  2PTQ A;  1HY1 A;  4NSL A;  1T6P A;  1RE5 A;  3R6V A;  1U15 A;  2O7B A;  2E9F A;  2QVE A;  4FLC A;  2PTS A;  4APA A;  2FUS A;  3BHG A;  1TJU A;  2PFM A;  4HGV A;  1GK2 A;  2O7D A;  1T6J A;  1J3U A;  1GK3 A;  5F92 A;  1YIS A;  1U16 A;  2OHY A;  1C3U A;  4C5U A;  4APB A;  3OCF A;  1TJW A;  1TJV A;  4C6G A;  4ADL A;  4EFC A;  1AUW A;  2PTR A;  1GKM A;  3C8T A;  1JSW A;  2QGA B;  3TV2 A;  1XWO A;  2RJR A;  3CZO A;  1W27 A;  4EEI A;  2O6Y A;  4V2Q A;  1GKJ A;  4ADM A;  4FFX A;  4NLE A;  2YII A;  3RD8 A;  3E04 A;  3R6Y A;  1HY0 A;  2J91 A;  5F91 A;  4MX2 A;  3RRP A;  3KDZ A;  4BAB A;  1VDK A;  2X75 A;  2NYF A;  1FUP A;  2O78 A;  1FUR A;  5D6B A;  1EB4 A;  2RJS A;  1FUO A;  1DOF A;  3OCE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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