1T6PA

Crystal structure of phenylalanine ammonia lyase from rhodosporidium toruloides
Total Genus 228
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
228
sequence length
687
structure length
653
Chain Sequence
TNLAVAGSHLPTTQVTQVDIVEKMLAAPTDSTLELDGYSLNLGDVVSAARKGRPVRVKDSDEIRSKIDKSVEFLRSEDAISLQKALLEHQLCGVLPSSFDSFRLGRGLENSLPLEVVRGAMTIRVNSLTRGHSAVRLVVLEALTNFLNHGITPIVPLRGTISDLSPLSYIAAAISGHPDSKVHVVHEGKEKILYAREAMALFNLEPVVLGPKEGLGLVNGTAVSASMATLALHDAHMLSLLSQSLTAMTVEAMVGHAGSFHPFLHDVTRPHPTQIEVAGNIRKLLEGSRFAVHHEEQDRYPLRTSPQWLGPLVSDLIHAHAVLTIEAGQSTTDNPLIDVENKTSHHGGNFQAAAVANTMEKTRLGLAQIGKLNFTQLTEMLNAGMNRGLPSCLAAEDPSLSYHCKGLDIAAAAYTSELGHLANPVTTHVQPAEMANQAVNSLALISARRTTESNDVLSLLLATHLYCVLQAIDLRAIEFEFKKQFGPAIVSLIDQHFGSAMTGSNLRDELVEKVNKTLAKRLEQTNSYDLVPRWHDAFSFAAGTVVEVLSSTSLSLAAVNAWKVAAAESAISLTRQVRETFWSAASTSSPALSYLSPRTQILYAFVREELGVKARRGDVFLGKQEVTIGSNVSKIYEAIKSGRINNVLLKMLA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords phenylalanine ammonia-lyase
publication title Crystal structure of phenylalanine ammonia lyase: multiple helix dipoles implicated in catalysis.
pubmed doi rcsb
source organism Rhodosporidium toruloides
molecule tags Lyase
total genus 228
structure length 653
sequence length 687
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 4.3.1.25: Phenylalanine/tyrosine ammonia-lyase.
pdb deposition date 2004-05-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 1t6pA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1t6pA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1t6pA02
2YIIA 1GK3A 3OCFA 4NSLA 2NYNA 1C3CA 2O6YA 3OCEA 4CQ5A 3R6QA 1FURA 2E9FA 2OHYA 5F92A 4FFXA 1C3UA 2RJSA 2NYFA 3GZHA 5EYTA 1GK2A 3CZOA 2HVGA 1U15A 3UNVA 2PFMA 4C6GA 1Y2MA 3NO9A 1T6JA 4BABA 5F91A 2O7BA 3RRPA 2RJRA 4NLEA 2PTRA 4C5SA 1KQ7A 1YFEA 1HY1A 5EYVA 3QBPA 1K62A 1TJUA 1VDKA 4V2QA 2QVEA 1GKMA 1FUQA 1GKJA 3TV2A 1TJWA 1FUOA 2O7DA 1YISA 1TJVA 1XWOA 4ADMA 4C5RA 3KDZA 3GTDA 4V2RA 2O7FA 1W27A 3NZ4A 1B8FA 2O7EA 1I0AA 1Q5NA 5HW2A 4FLCA 2X75A 3RD8A 4EFCA 2O78A 1AUWA 3BHGA 2PTSA 1RE5A 4APBA 3C8TA 1J3UA 1T6PA 3R6YA 4BAAA 4HGVA 3E04A 2QGAB 4C5UA 2VD6A 2PTQA 4APAA 1HY0A 4MX2A 1EB4A 1FUPA 1K7WA 1DCNA 1YFMA 2FUSA 2J91A 4ADLA 3KDYA 4EEIA 5D6BA 1DOFA 3R6VA 1TJ7A 1JSWA 1U16A
chains in the Genus database with same CATH superfamily
2YIIA 4CEHA 2X0QA 3EZBA 2Y0NA 1GK3A 2VUMA 3OCFA 4NSLA 1I6VD 2NYNA 1YNND 3GTQA 1C3CA 2O6YA 2K3NA 3OCEA 4CQ5A 2X0OA 3R6QA 3GTJA 1FURA 3GTGA 2E9FA 2EZBA 2OHYA 5F92A 2FIPA 2BE5D 3LR8A 1R9TA 1Y1VA 1TWCA 1C3UA 2RJSA 3H0GA 4FFXA 5M0JA 1TWHA 1XLYA 2VSFA 2NYFA 4A15A 3GZHA 5EYTA 2K3OA 3LR2A 2JA6A 1GK2A 3CZOA 5H8WA 2A6ED 2JA7A 1XMCA 1ZYMA 2LPIA 1U15A 2HVGA 3UNVA 5M0IA 2R92A 1ZYRD 2PFMA 3GTLA 4C6GA 2R7ZA 4C2MA 2JA5A 1Y2MA 3GTMA 3NO9A 1T6JA 4BABA 2NVXA 2A6HD 5F91A 2O7BA 3RRPA 1TWFA 2RJRA 1I3QA 4NLEA 4QIWA 2PTRA 4C5SA 1KQ7A 1YFEA 1HY1A 5EYVA 1HQMD 3U44A 1K62A 3QBPA 1TJUA 2LPJA 1VDKA 2B63A 2NVYA 3EZAA 1SFOA 2HWGA 4V2QA 2QVEA 2FENA 1GKMA 2VL7A 3LRDA 1FUQA 1GKJA 2X0PA 2YU9A 3TV2A 1TJWA 2N1DB 1FUOA 1XL8A 1IW7D 3FKIA 1XL7A 2MX9A 2O7DA 1YISA 1TJVA 1XWOA 2FIOA 4ADMA 2LYIA 4C5RA 2R93A 3KDZA 3GTDA 4V2RA 2O7FA 1W27A 2A69D 2MP0A 3NZ4A 1XMDA 3EZEA 1B8FA 2O7EA 1I0AA 1Q5NA 2F5JA 5HW2A 4FLCA 2X75A 3CRVA 2MQAA 3RD8A 4EFCA 1I50A 2VK9A 2MX8A 2FELA 2O78A 2CW0D 1AUWA 1TWAA 4CEIA 3BHGA 2PTSA 2E2HA 1RE5A 4APBA 2A68D 3GTOA 2LTHA 1K83A 2EZCA 3C8TA 1WCMA 3GTKA 1TWGA 1J3UA 5IZ2A 1T6PA 2N3EA 3R6YA 3CQZA 4BAAA 3GTPA 4HGVA 3E04A 4FBSA 2EZAA 2QGAB 2AQLA 4C5UA 1Y1WA 2VD6A 2PTQA 1YNJD 2E2IA 2K3QA 1HY0A 4APAA 2HROA 4MX2A 1EZBA 1EB4A 3U4QA 4WNLA 1FUPA 4CEJA 1K7WA 1DCNA 1YFMA 2FUSA 2J91A 4ADLA 3KDYA 4EEIA 1SMYD 3LR6A 5D6BA 1EZAA 2O5JD 1DOFA 3R6VA 1TJ7A 3CRW1 1JSWA 2LKMB 1U16A
chains in the Genus database with same CATH topology
2YIIA 1GK3A 3OCFA 4NSLA 2NYNA 1C3CA 2O6YA 3OCEA 4CQ5A 3R6QA 1FURA 2E9FA 2OHYA 5F92A 4FFXA 1C3UA 2RJSA 2NYFA 3GZHA 5EYTA 1GK2A 3CZOA 2HVGA 1U15A 3UNVA 2PFMA 4C6GA 1Y2MA 3NO9A 1T6JA 4BABA 5F91A 2O7BA 3RRPA 2RJRA 4NLEA 2PTRA 4C5SA 1KQ7A 1YFEA 1HY1A 5EYVA 3QBPA 1K62A 1TJUA 1VDKA 4V2QA 2QVEA 1GKMA 1FUQA 1GKJA 3TV2A 1TJWA 1FUOA 2O7DA 1YISA 1TJVA 1XWOA 4ADMA 4C5RA 3KDZA 3GTDA 4V2RA 2O7FA 1W27A 3NZ4A 1B8FA 2O7EA 1I0AA 1Q5NA 5HW2A 4FLCA 2X75A 3RD8A 4EFCA 2O78A 1AUWA 3BHGA 2PTSA 1RE5A 4APBA 3C8TA 1J3UA 1T6PA 3R6YA 4BAAA 4HGVA 3E04A 2QGAB 4C5UA 2VD6A 2PTQA 4APAA 1HY0A 4MX2A 1EB4A 1FUPA 1K7WA 1DCNA 1YFMA 2FUSA 2J91A 4ADLA 3KDYA 4EEIA 5D6BA 1DOFA 3R6VA 1TJ7A 1JSWA 1U16A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2YII A;  1GK3 A;  3OCF A;  4NSL A;  2NYN A;  1C3C A;  2O6Y A;  3OCE A;  4CQ5 A;  3R6Q A;  1FUR A;  2E9F A;  2OHY A;  5F92 A;  4FFX A;  1C3U A;  2RJS A;  2NYF A;  3GZH A;  5EYT A;  1GK2 A;  3CZO A;  2HVG A;  1U15 A;  3UNV A;  2PFM A;  4C6G A;  1Y2M A;  3NO9 A;  1T6J A;  4BAB A;  5F91 A;  2O7B A;  3RRP A;  2RJR A;  4NLE A;  2PTR A;  4C5S A;  1KQ7 A;  1YFE A;  1HY1 A;  5EYV A;  3QBP A;  1K62 A;  1TJU A;  1VDK A;  4V2Q A;  2QVE A;  1GKM A;  1FUQ A;  1GKJ A;  3TV2 A;  1TJW A;  1FUO A;  2O7D A;  1YIS A;  1TJV A;  1XWO A;  4ADM A;  4C5R A;  3KDZ A;  3GTD A;  4V2R A;  2O7F A;  1W27 A;  3NZ4 A;  1B8F A;  2O7E A;  1I0A A;  1Q5N A;  5HW2 A;  4FLC A;  2X75 A;  3RD8 A;  4EFC A;  2O78 A;  1AUW A;  3BHG A;  2PTS A;  1RE5 A;  4APB A;  3C8T A;  1J3U A;  1T6P A;  3R6Y A;  4BAA A;  4HGV A;  3E04 A;  2QGA B;  4C5U A;  2VD6 A;  2PTQ A;  4APA A;  1HY0 A;  4MX2 A;  1EB4 A;  1FUP A;  1K7W A;  1DCN A;  1YFM A;  2FUS A;  2J91 A;  4ADL A;  3KDY A;  4EEI A;  5D6B A;  1DOF A;  3R6V A;  1TJ7 A;  1JSW A;  1U16 A; 
#chains in the Genus database with same CATH topology
 2YII A;  4CEH A;  2X0Q A;  3EZB A;  2Y0N A;  1GK3 A;  2VUM A;  3OCF A;  4NSL A;  1I6V D;  2NYN A;  1YNN D;  3GTQ A;  1C3C A;  2O6Y A;  2K3N A;  3OCE A;  4CQ5 A;  2X0O A;  3R6Q A;  3GTJ A;  1FUR A;  3GTG A;  2E9F A;  2EZB A;  2OHY A;  5F92 A;  2FIP A;  2BE5 D;  3LR8 A;  1R9T A;  1Y1V A;  1TWC A;  1C3U A;  2RJS A;  3H0G A;  4FFX A;  5M0J A;  1TWH A;  1XLY A;  2VSF A;  2NYF A;  4A15 A;  3GZH A;  5EYT A;  2K3O A;  3LR2 A;  2JA6 A;  1GK2 A;  3CZO A;  5H8W A;  2A6E D;  2JA7 A;  1XMC A;  1ZYM A;  2LPI A;  1U15 A;  2HVG A;  3UNV A;  5M0I A;  2R92 A;  1ZYR D;  2PFM A;  3GTL A;  4C6G A;  2R7Z A;  4C2M A;  2JA5 A;  1Y2M A;  3GTM A;  3NO9 A;  1T6J A;  4BAB A;  2NVX A;  2A6H D;  5F91 A;  2O7B A;  3RRP A;  1TWF A;  2RJR A;  1I3Q A;  4NLE A;  4QIW A;  2PTR A;  4C5S A;  1KQ7 A;  1YFE A;  1HY1 A;  5EYV A;  1HQM D;  3U44 A;  1K62 A;  3QBP A;  1TJU A;  2LPJ A;  1VDK A;  2B63 A;  2NVY A;  3EZA A;  1SFO A;  2HWG A;  4V2Q A;  2QVE A;  2FEN A;  1GKM A;  2VL7 A;  3LRD A;  1FUQ A;  1GKJ A;  2X0P A;  2YU9 A;  3TV2 A;  1TJW A;  2N1D B;  1FUO A;  1XL8 A;  1IW7 D;  3FKI A;  1XL7 A;  2MX9 A;  2O7D A;  1YIS A;  1TJV A;  1XWO A;  2FIO A;  4ADM A;  2LYI A;  4C5R A;  2R93 A;  3KDZ A;  3GTD A;  4V2R A;  2O7F A;  1W27 A;  2A69 D;  2MP0 A;  3NZ4 A;  1XMD A;  3EZE A;  1B8F A;  2O7E A;  1I0A A;  1Q5N A;  2F5J A;  5HW2 A;  4FLC A;  2X75 A;  3CRV A;  2MQA A;  3RD8 A;  4EFC A;  1I50 A;  2VK9 A;  2MX8 A;  2FEL A;  2O78 A;  2CW0 D;  1AUW A;  1TWA A;  4CEI A;  3BHG A;  2PTS A;  2E2H A;  1RE5 A;  4APB A;  2A68 D;  3GTO A;  2LTH A;  1K83 A;  2EZC A;  3C8T A;  1WCM A;  3GTK A;  1TWG A;  1J3U A;  5IZ2 A;  1T6P A;  2N3E A;  3R6Y A;  3CQZ A;  4BAA A;  3GTP A;  4HGV A;  3E04 A;  4FBS A;  2EZA A;  2QGA B;  2AQL A;  4C5U A;  1Y1W A;  2VD6 A;  2PTQ A;  1YNJ D;  2E2I A;  2K3Q A;  1HY0 A;  4APA A;  2HRO A;  4MX2 A;  1EZB A;  1EB4 A;  3U4Q A;  4WNL A;  1FUP A;  4CEJ A;  1K7W A;  1DCN A;  1YFM A;  2FUS A;  2J91 A;  4ADL A;  3KDY A;  4EEI A;  1SMY D;  3LR6 A;  5D6B A;  1EZA A;  2O5J D;  1DOF A;  3R6V A;  1TJ7 A;  3CRW 1;  1JSW A;  2LKM B;  1U16 A; 
#chains in the Genus database with same CATH homology
 2YII A;  1GK3 A;  3OCF A;  4NSL A;  2NYN A;  1C3C A;  2O6Y A;  3OCE A;  4CQ5 A;  3R6Q A;  1FUR A;  2E9F A;  2OHY A;  5F92 A;  4FFX A;  1C3U A;  2RJS A;  2NYF A;  3GZH A;  5EYT A;  1GK2 A;  3CZO A;  2HVG A;  1U15 A;  3UNV A;  2PFM A;  4C6G A;  1Y2M A;  3NO9 A;  1T6J A;  4BAB A;  5F91 A;  2O7B A;  3RRP A;  2RJR A;  4NLE A;  2PTR A;  4C5S A;  1KQ7 A;  1YFE A;  1HY1 A;  5EYV A;  3QBP A;  1K62 A;  1TJU A;  1VDK A;  4V2Q A;  2QVE A;  1GKM A;  1FUQ A;  1GKJ A;  3TV2 A;  1TJW A;  1FUO A;  2O7D A;  1YIS A;  1TJV A;  1XWO A;  4ADM A;  4C5R A;  3KDZ A;  3GTD A;  4V2R A;  2O7F A;  1W27 A;  3NZ4 A;  1B8F A;  2O7E A;  1I0A A;  1Q5N A;  5HW2 A;  4FLC A;  2X75 A;  3RD8 A;  4EFC A;  2O78 A;  1AUW A;  3BHG A;  2PTS A;  1RE5 A;  4APB A;  3C8T A;  1J3U A;  1T6P A;  3R6Y A;  4BAA A;  4HGV A;  3E04 A;  2QGA B;  4C5U A;  2VD6 A;  2PTQ A;  4APA A;  1HY0 A;  4MX2 A;  1EB4 A;  1FUP A;  1K7W A;  1DCN A;  1YFM A;  2FUS A;  2J91 A;  4ADL A;  3KDY A;  4EEI A;  5D6B A;  1DOF A;  3R6V A;  1TJ7 A;  1JSW A;  1U16 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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