1T6PA

Crystal structure of phenylalanine ammonia lyase from rhodosporidium toruloides
Total Genus 228
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
228
sequence length
687
structure length
653
Chain Sequence
TNLAVAGSHLPTTQVTQVDIVEKMLAAPTDSTLELDGYSLNLGDVVSAARKGRPVRVKDSDEIRSKIDKSVEFLRSEDAISLQKALLEHQLCGVLPSSFDSFRLGRGLENSLPLEVVRGAMTIRVNSLTRGHSAVRLVVLEALTNFLNHGITPIVPLRGTISDLSPLSYIAAAISGHPDSKVHVVHEGKEKILYAREAMALFNLEPVVLGPKEGLGLVNGTAVSASMATLALHDAHMLSLLSQSLTAMTVEAMVGHAGSFHPFLHDVTRPHPTQIEVAGNIRKLLEGSRFAVHHEEQDRYPLRTSPQWLGPLVSDLIHAHAVLTIEAGQSTTDNPLIDVENKTSHHGGNFQAAAVANTMEKTRLGLAQIGKLNFTQLTEMLNAGMNRGLPSCLAAEDPSLSYHCKGLDIAAAAYTSELGHLANPVTTHVQPAEMANQAVNSLALISARRTTESNDVLSLLLATHLYCVLQAIDLRAIEFEFKKQFGPAIVSLIDQHFGSAMTGSNLRDELVEKVNKTLAKRLEQTNSYDLVPRWHDAFSFAAGTVVEVLSSTSLSLAAVNAWKVAAAESAISLTRQVRETFWSAASTSSPALSYLSPRTQILYAFVREELGVKARRGDVFLGKQEVTIGSNVSKIYEAIKSGRINNVLLKMLA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords phenylalanine ammonia-lyase
publication title Crystal structure of phenylalanine ammonia lyase: multiple helix dipoles implicated in catalysis.
pubmed doi rcsb
source organism Rhodosporidium toruloides
molecule tags Lyase
total genus 228
structure length 653
sequence length 687
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 4.3.1.25: Phenylalanine/tyrosine ammonia-lyase.
pdb deposition date 2004-05-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 1t6pA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1t6pA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1t6pA02
1C3CA 3CZOA 1Q5NA 4BAAA 4FLCA 4HGVA 4C5UA 4EFCA 1GKMA 1KQ7A 2O78A 3KDYA 2RJSA 3KDZA 3R6YA 2X75A 3RRPA 1I0AA 1K7WA 2NYFA 1K62A 3R6VA 1Y2MA 2QGAB 5EYTA 2PFMA 1FUOA 1GK2A 3C8TA 1T6JA 2O7BA 2O6YA 1T6PA 5F92A 1B8FA 1GKJA 2O7DA 1RE5A 2FUSA 1U15A 1DCNA 1HY1A 1JSWA 1TJUA 1EB4A 3OCFA 1TJWA 1FURA 4C5SA 3QBPA 1DOFA 1AUWA 5F91A 5HW2A 1C3UA 2O7EA 3GZHA 2NYNA 1FUPA 3UNVA 1GK3A 4V2QA 1HY0A 3E04A 1J3UA 2YIIA 2RJRA 2E9FA 2QVEA 3GTDA 1TJ7A 4MX2A 3RD8A 5D6BA 1YFMA 2HVGA 2VD6A 1XWOA 1W27A 4ADMA 2O7FA 2PTSA 4APAA 4APBA 3OCEA 3TV2A 3NO9A 3NZ4A 1FUQA 4ADLA 3R6QA 2OHYA 4NLEA 4NSLA 4V2RA 4C5RA 4C6GA 1YISA 1VDKA 1U16A 2PTRA 1TJVA 3BHGA 2PTQA 4EEIA 4BABA 5EYVA 4CQ5A 2J91A 4FFXA 1YFEA
chains in the Genus database with same CATH superfamily
1C3CA 4CEHA 3CZOA 1Q5NA 1SFOA 2X0QA 1IW7D 4BAAA 3GTKA 3LR6A 4FLCA 1YNJD 3LR8A 2LKMB 4C5UA 4CEIA 1GKMA 4HGVA 4EFCA 1KQ7A 2O78A 4FBSA 2JA7A 2Y0NA 2E2HA 3KDYA 2RJSA 3KDZA 2F5JA 3R6YA 2X75A 3RRPA 2FIOA 2LTHA 2MP0A 2K3QA 5M0JA 1I0AA 2E2IA 1K7WA 2NYFA 1K62A 4WNLA 3R6VA 2HWGA 1Y2MA 2QGAB 1SMYD 5EYTA 2X0PA 2PFMA 2R7ZA 3GTLA 1FUOA 1GK2A 3C8TA 3LRDA 2BE5D 3GTGA 3EZAA 1T6JA 2NVXA 2O7BA 1TWFA 2O5JD 2A69D 2O6YA 1ZYMA 2EZBA 1T6PA 5F92A 1B8FA 2R92A 1GKJA 2O7DA 2EZCA 2JA6A 1RE5A 1U15A 2FUSA 2VSFA 2LPJA 2B63A 2LYIA 1DCNA 1HQMD 4A15A 2YU9A 2MQAA 1XLYA 2A6ED 3GTMA 3LR2A 1HY1A 1JSWA 1TJUA 1EB4A 2K3OA 1XL7A 3OCFA 4EEIA 1TJWA 1FURA 1TWHA 1Y1VA 4C5SA 3QBPA 2JA5A 5M0IA 1TWAA 2MX9A 1I50A 2EZAA 1DOFA 1AUWA 1XMCA 5IZ2A 5F91A 3U4QA 5HW2A 1C3UA 2O7EA 3GZHA 3CRW1 5H8WA 2NYNA 3GTPA 1FUPA 3UNVA 2LPIA 1GK3A 4V2QA 1HY0A 3E04A 1J3UA 2MX8A 2YIIA 3FKIA 2RJRA 1XL8A 1R9TA 2E9FA 2FELA 1YNND 2AQLA 2QVEA 3GTDA 3CRVA 1Y1WA 3GTOA 4QIWA 1TJ7A 4MX2A 3RD8A 2N1DB 3GTJA 5D6BA 2CW0D 1YFMA 3CQZA 2HVGA 2VD6A 1K83A 1EZBA 2VUMA 1XWOA 1W27A 3EZEA 4ADMA 2O7FA 2PTSA 4APAA 2VL7A 4APBA 3OCEA 4C2MA 3TV2A 3NO9A 3NZ4A 1TWGA 1FUQA 4ADLA 1EZAA 1WCMA 2N3EA 3H0GA 1I3QA 2K3NA 2OHYA 3R6QA 2VK9A 1TWCA 4NLEA 2FIPA 2FENA 2NVYA 2X0OA 4V2RA 2A68D 4NSLA 4CEJA 4C5RA 2HROA 4C6GA 1YISA 2A6HD 1U16A 1VDKA 3GTQA 2PTRA 1TJVA 1ZYRD 3EZBA 2PTQA 3BHGA 4BABA 3U44A 4CQ5A 2R93A 2J91A 1YFEA 4FFXA 5EYVA 1XMDA 1I6VD
chains in the Genus database with same CATH topology
1C3CA 3CZOA 1Q5NA 4BAAA 4FLCA 4HGVA 4C5UA 4EFCA 1GKMA 1KQ7A 2O78A 3KDYA 2RJSA 3KDZA 3R6YA 2X75A 3RRPA 1I0AA 1K7WA 2NYFA 1K62A 3R6VA 1Y2MA 2QGAB 5EYTA 2PFMA 1FUOA 1GK2A 3C8TA 1T6JA 2O7BA 2O6YA 1T6PA 5F92A 1B8FA 1GKJA 2O7DA 1RE5A 2FUSA 1U15A 1DCNA 1HY1A 1JSWA 1TJUA 1EB4A 3OCFA 1TJWA 1FURA 4C5SA 3QBPA 1DOFA 1AUWA 5F91A 5HW2A 1C3UA 2O7EA 3GZHA 2NYNA 1FUPA 3UNVA 1GK3A 4V2QA 1HY0A 3E04A 1J3UA 2YIIA 2RJRA 2E9FA 2QVEA 3GTDA 1TJ7A 4MX2A 3RD8A 5D6BA 1YFMA 2HVGA 2VD6A 1XWOA 1W27A 4ADMA 2O7FA 2PTSA 4APAA 4APBA 3OCEA 3TV2A 3NO9A 3NZ4A 1FUQA 4ADLA 3R6QA 2OHYA 4NLEA 4NSLA 4V2RA 4C5RA 4C6GA 1YISA 1VDKA 1U16A 2PTRA 1TJVA 3BHGA 2PTQA 4EEIA 4BABA 5EYVA 4CQ5A 2J91A 4FFXA 1YFEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1C3C A;  3CZO A;  1Q5N A;  4BAA A;  4FLC A;  4HGV A;  4C5U A;  4EFC A;  1GKM A;  1KQ7 A;  2O78 A;  3KDY A;  2RJS A;  3KDZ A;  3R6Y A;  2X75 A;  3RRP A;  1I0A A;  1K7W A;  2NYF A;  1K62 A;  3R6V A;  1Y2M A;  2QGA B;  5EYT A;  2PFM A;  1FUO A;  1GK2 A;  3C8T A;  1T6J A;  2O7B A;  2O6Y A;  1T6P A;  5F92 A;  1B8F A;  1GKJ A;  2O7D A;  1RE5 A;  2FUS A;  1U15 A;  1DCN A;  1HY1 A;  1JSW A;  1TJU A;  1EB4 A;  3OCF A;  1TJW A;  1FUR A;  4C5S A;  3QBP A;  1DOF A;  1AUW A;  5F91 A;  5HW2 A;  1C3U A;  2O7E A;  3GZH A;  2NYN A;  1FUP A;  3UNV A;  1GK3 A;  4V2Q A;  1HY0 A;  3E04 A;  1J3U A;  2YII A;  2RJR A;  2E9F A;  2QVE A;  3GTD A;  1TJ7 A;  4MX2 A;  3RD8 A;  5D6B A;  1YFM A;  2HVG A;  2VD6 A;  1XWO A;  1W27 A;  4ADM A;  2O7F A;  2PTS A;  4APA A;  4APB A;  3OCE A;  3TV2 A;  3NO9 A;  3NZ4 A;  1FUQ A;  4ADL A;  3R6Q A;  2OHY A;  4NLE A;  4NSL A;  4V2R A;  4C5R A;  4C6G A;  1YIS A;  1VDK A;  1U16 A;  2PTR A;  1TJV A;  3BHG A;  2PTQ A;  4EEI A;  4BAB A;  5EYV A;  4CQ5 A;  2J91 A;  4FFX A;  1YFE A; 
#chains in the Genus database with same CATH topology
 1C3C A;  4CEH A;  3CZO A;  1Q5N A;  1SFO A;  2X0Q A;  1IW7 D;  4BAA A;  3GTK A;  3LR6 A;  4FLC A;  1YNJ D;  3LR8 A;  2LKM B;  4C5U A;  4CEI A;  1GKM A;  4HGV A;  4EFC A;  1KQ7 A;  2O78 A;  4FBS A;  2JA7 A;  2Y0N A;  2E2H A;  3KDY A;  2RJS A;  3KDZ A;  2F5J A;  3R6Y A;  2X75 A;  3RRP A;  2FIO A;  2LTH A;  2MP0 A;  2K3Q A;  5M0J A;  1I0A A;  2E2I A;  1K7W A;  2NYF A;  1K62 A;  4WNL A;  3R6V A;  2HWG A;  1Y2M A;  2QGA B;  1SMY D;  5EYT A;  2X0P A;  2PFM A;  2R7Z A;  3GTL A;  1FUO A;  1GK2 A;  3C8T A;  3LRD A;  2BE5 D;  3GTG A;  3EZA A;  1T6J A;  2NVX A;  2O7B A;  1TWF A;  2O5J D;  2A69 D;  2O6Y A;  1ZYM A;  2EZB A;  1T6P A;  5F92 A;  1B8F A;  2R92 A;  1GKJ A;  2O7D A;  2EZC A;  2JA6 A;  1RE5 A;  1U15 A;  2FUS A;  2VSF A;  2LPJ A;  2B63 A;  2LYI A;  1DCN A;  1HQM D;  4A15 A;  2YU9 A;  2MQA A;  1XLY A;  2A6E D;  3GTM A;  3LR2 A;  1HY1 A;  1JSW A;  1TJU A;  1EB4 A;  2K3O A;  1XL7 A;  3OCF A;  4EEI A;  1TJW A;  1FUR A;  1TWH A;  1Y1V A;  4C5S A;  3QBP A;  2JA5 A;  5M0I A;  1TWA A;  2MX9 A;  1I50 A;  2EZA A;  1DOF A;  1AUW A;  1XMC A;  5IZ2 A;  5F91 A;  3U4Q A;  5HW2 A;  1C3U A;  2O7E A;  3GZH A;  3CRW 1;  5H8W A;  2NYN A;  3GTP A;  1FUP A;  3UNV A;  2LPI A;  1GK3 A;  4V2Q A;  1HY0 A;  3E04 A;  1J3U A;  2MX8 A;  2YII A;  3FKI A;  2RJR A;  1XL8 A;  1R9T A;  2E9F A;  2FEL A;  1YNN D;  2AQL A;  2QVE A;  3GTD A;  3CRV A;  1Y1W A;  3GTO A;  4QIW A;  1TJ7 A;  4MX2 A;  3RD8 A;  2N1D B;  3GTJ A;  5D6B A;  2CW0 D;  1YFM A;  3CQZ A;  2HVG A;  2VD6 A;  1K83 A;  1EZB A;  2VUM A;  1XWO A;  1W27 A;  3EZE A;  4ADM A;  2O7F A;  2PTS A;  4APA A;  2VL7 A;  4APB A;  3OCE A;  4C2M A;  3TV2 A;  3NO9 A;  3NZ4 A;  1TWG A;  1FUQ A;  4ADL A;  1EZA A;  1WCM A;  2N3E A;  3H0G A;  1I3Q A;  2K3N A;  2OHY A;  3R6Q A;  2VK9 A;  1TWC A;  4NLE A;  2FIP A;  2FEN A;  2NVY A;  2X0O A;  4V2R A;  2A68 D;  4NSL A;  4CEJ A;  4C5R A;  2HRO A;  4C6G A;  1YIS A;  2A6H D;  1U16 A;  1VDK A;  3GTQ A;  2PTR A;  1TJV A;  1ZYR D;  3EZB A;  2PTQ A;  3BHG A;  4BAB A;  3U44 A;  4CQ5 A;  2R93 A;  2J91 A;  1YFE A;  4FFX A;  5EYV A;  1XMD A;  1I6V D; 
#chains in the Genus database with same CATH homology
 1C3C A;  3CZO A;  1Q5N A;  4BAA A;  4FLC A;  4HGV A;  4C5U A;  4EFC A;  1GKM A;  1KQ7 A;  2O78 A;  3KDY A;  2RJS A;  3KDZ A;  3R6Y A;  2X75 A;  3RRP A;  1I0A A;  1K7W A;  2NYF A;  1K62 A;  3R6V A;  1Y2M A;  2QGA B;  5EYT A;  2PFM A;  1FUO A;  1GK2 A;  3C8T A;  1T6J A;  2O7B A;  2O6Y A;  1T6P A;  5F92 A;  1B8F A;  1GKJ A;  2O7D A;  1RE5 A;  2FUS A;  1U15 A;  1DCN A;  1HY1 A;  1JSW A;  1TJU A;  1EB4 A;  3OCF A;  1TJW A;  1FUR A;  4C5S A;  3QBP A;  1DOF A;  1AUW A;  5F91 A;  5HW2 A;  1C3U A;  2O7E A;  3GZH A;  2NYN A;  1FUP A;  3UNV A;  1GK3 A;  4V2Q A;  1HY0 A;  3E04 A;  1J3U A;  2YII A;  2RJR A;  2E9F A;  2QVE A;  3GTD A;  1TJ7 A;  4MX2 A;  3RD8 A;  5D6B A;  1YFM A;  2HVG A;  2VD6 A;  1XWO A;  1W27 A;  4ADM A;  2O7F A;  2PTS A;  4APA A;  4APB A;  3OCE A;  3TV2 A;  3NO9 A;  3NZ4 A;  1FUQ A;  4ADL A;  3R6Q A;  2OHY A;  4NLE A;  4NSL A;  4V2R A;  4C5R A;  4C6G A;  1YIS A;  1VDK A;  1U16 A;  2PTR A;  1TJV A;  3BHG A;  2PTQ A;  4EEI A;  4BAB A;  5EYV A;  4CQ5 A;  2J91 A;  4FFX A;  1YFE A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...