1T6PA

Crystal structure of phenylalanine ammonia lyase from rhodosporidium toruloides
Total Genus 228
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
228
sequence length
687
structure length
653
Chain Sequence
TNLAVAGSHLPTTQVTQVDIVEKMLAAPTDSTLELDGYSLNLGDVVSAARKGRPVRVKDSDEIRSKIDKSVEFLRSEDAISLQKALLEHQLCGVLPSSFDSFRLGRGLENSLPLEVVRGAMTIRVNSLTRGHSAVRLVVLEALTNFLNHGITPIVPLRGTISDLSPLSYIAAAISGHPDSKVHVVHEGKEKILYAREAMALFNLEPVVLGPKEGLGLVNGTAVSASMATLALHDAHMLSLLSQSLTAMTVEAMVGHAGSFHPFLHDVTRPHPTQIEVAGNIRKLLEGSRFAVHHEEQDRYPLRTSPQWLGPLVSDLIHAHAVLTIEAGQSTTDNPLIDVENKTSHHGGNFQAAAVANTMEKTRLGLAQIGKLNFTQLTEMLNAGMNRGLPSCLAAEDPSLSYHCKGLDIAAAAYTSELGHLANPVTTHVQPAEMANQAVNSLALISARRTTESNDVLSLLLATHLYCVLQAIDLRAIEFEFKKQFGPAIVSLIDQHFGSAMTGSNLRDELVEKVNKTLAKRLEQTNSYDLVPRWHDAFSFAAGTVVEVLSSTSLSLAAVNAWKVAAAESAISLTRQVRETFWSAASTSSPALSYLSPRTQILYAFVREELGVKARRGDVFLGKQEVTIGSNVSKIYEAIKSGRINNVLLKMLA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structure of phenylalanine ammonia lyase: multiple helix dipoles implicated in catalysis.
pubmed doi rcsb
source organism Rhodosporidium toruloides
molecule tags Lyase
molecule keywords phenylalanine ammonia-lyase
total genus 228
structure length 653
sequence length 687
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 4.3.1.25: Phenylalanine/tyrosine ammonia-lyase.
pdb deposition date 2004-05-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 1t6pA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1t6pA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1t6pA02
5F92A 3KDYA 2QGAB 2O7BA 3NZ4A 4C5SA 3QBPA 1B8FA 3GZHA 1FURA 1GKJA 4BABA 1KQ7A 1J3UA 1C3UA 2RJRA 4C6GA 4NSLA 2HVGA 1Q5NA 4BAAA 1TJ7A 2PTRA 2FUSA 3UNVA 1VDKA 1EB4A 1FUOA 1T6PA 4FLCA 4APBA 3NO9A 1K62A 1YFEA 1GK3A 1TJVA 3OCFA 5EYTA 4NLEA 3OCEA 4V2RA 3BHGA 3KDZA 1DCNA 3TV2A 2X75A 1FUQA 1FUPA 2RJSA 2YIIA 5EYVA 1W27A 1RE5A 4EEIA 1TJUA 4FFXA 1U16A 2O6YA 2O7EA 5D6BA 4C5RA 1T6JA 3GTDA 1YFMA 1DOFA 3E04A 1U15A 1I0AA 1TJWA 2NYNA 4ADLA 5F91A 1GKMA 1K7WA 2OHYA 4MX2A 4C5UA 3CZOA 2PTSA 3RD8A 2PTQA 1JSWA 2QVEA 1AUWA 4V2QA 1HY1A 2J91A 5HW2A 1YISA 4CQ5A 4HGVA 1C3CA 2E9FA 3R6VA 4ADMA 2O7DA 4EFCA 2O7FA 1Y2MA 3R6QA 4APAA 1XWOA 3C8TA 2O78A 1GK2A 3R6YA 1HY0A 2PFMA 2VD6A 3RRPA 2NYFA
chains in the Genus database with same CATH superfamily
2VSFA 5F92A 3KDYA 2QGAB 2O7BA 1HQMD 3NZ4A 4C5SA 1Y1WA 3QBPA 1XL7A 3FKIA 1B8FA 3GZHA 1FURA 1GKJA 4BABA 2MP0A 1KQ7A 1SFOA 2X0PA 1J3UA 1C3UA 3LR6A 3LRDA 4C6GA 2LKMB 3H0GA 1Q5NA 4BAAA 2HVGA 2RJRA 4NSLA 2JA5A 1EZAA 1SMYD 1TJ7A 2PTRA 2FUSA 1TWFA 3UNVA 1VDKA 2MX8A 1EB4A 2YU9A 1FUOA 2R92A 2Y0NA 2N1DB 1T6PA 4FLCA 4APBA 2FIOA 3NO9A 1K62A 5IZ2A 3EZBA 1YFEA 1GK3A 2FENA 1TJVA 2LPJA 3OCFA 2X0QA 5EYTA 2MQAA 4NLEA 3OCEA 4CEJA 2A6HD 4V2RA 3BHGA 2EZBA 2K3NA 4C2MA 3KDZA 1TWCA 3CRW1 4CEIA 3GTJA 1DCNA 1WCMA 3LR2A 2X75A 3TV2A 1FUQA 2X0OA 2AQLA 1FUPA 2A6ED 2JA7A 2RJSA 2YIIA 5EYVA 1YNND 3CRVA 5M0IA 1W27A 2R93A 2MX9A 1RE5A 3U44A 3EZEA 4EEIA 1XLYA 1I6VD 3GTOA 1TJUA 4FFXA 2HWGA 1U16A 2O7EA 2O6YA 5D6BA 4C5RA 2B63A 1T6JA 3GTDA 2EZCA 3CQZA 1YFMA 1DOFA 3E04A 2VK9A 1TWAA 1U15A 1XMDA 1I0AA 3GTPA 2VL7A 1XMCA 1TJWA 1K83A 2NYNA 4FBSA 4ADLA 3GTQA 5F91A 3GTKA 1GKMA 4WNLA 1K7WA 2OHYA 2K3QA 4MX2A 4C5UA 3CZOA 2PTSA 2CW0D 2JA6A 1I50A 3RD8A 1IW7D 2PTQA 1JSWA 2QVEA 1TWHA 3U4QA 1AUWA 4V2QA 2E2HA 1HY1A 2J91A 5HW2A 1ZYRD 2F5JA 2LPIA 1YISA 4CQ5A 2N3EA 2E2IA 3GTLA 1EZBA 4QIWA 4HGVA 1C3CA 2E9FA 5M0JA 2LYIA 3R6VA 2EZAA 1XL8A 4ADMA 2O7DA 2A68D 3EZAA 4EFCA 2O7FA 1Y2MA 4A15A 2A69D 3R6QA 3LR8A 1R9TA 4APAA 1ZYMA 2NVYA 2LTHA 2O5JD 2HROA 1XWOA 3C8TA 2FIPA 3GTGA 5H8WA 2O78A 1TWGA 1GK2A 2BE5D 4CEHA 3R6YA 1Y1VA 2K3OA 2VUMA 2NVXA 1HY0A 2FELA 1I3QA 2PFMA 2VD6A 3GTMA 3RRPA 2NYFA 1YNJD 2R7ZA
chains in the Genus database with same CATH topology
5F92A 3KDYA 2QGAB 2O7BA 3NZ4A 4C5SA 3QBPA 1B8FA 3GZHA 1FURA 1GKJA 4BABA 1KQ7A 1J3UA 1C3UA 2RJRA 4C6GA 4NSLA 2HVGA 1Q5NA 4BAAA 1TJ7A 2PTRA 2FUSA 3UNVA 1VDKA 1EB4A 1FUOA 1T6PA 4FLCA 4APBA 3NO9A 1K62A 1YFEA 1GK3A 1TJVA 3OCFA 5EYTA 4NLEA 3OCEA 4V2RA 3BHGA 3KDZA 1DCNA 3TV2A 2X75A 1FUQA 1FUPA 2RJSA 2YIIA 5EYVA 1W27A 1RE5A 4EEIA 1TJUA 4FFXA 1U16A 2O6YA 2O7EA 5D6BA 4C5RA 1T6JA 3GTDA 1YFMA 1DOFA 3E04A 1U15A 1I0AA 1TJWA 2NYNA 4ADLA 5F91A 1GKMA 1K7WA 2OHYA 4MX2A 4C5UA 3CZOA 2PTSA 3RD8A 2PTQA 1JSWA 2QVEA 1AUWA 4V2QA 1HY1A 2J91A 5HW2A 1YISA 4CQ5A 4HGVA 1C3CA 2E9FA 3R6VA 4ADMA 2O7DA 4EFCA 2O7FA 1Y2MA 3R6QA 4APAA 1XWOA 3C8TA 2O78A 1GK2A 3R6YA 1HY0A 2PFMA 2VD6A 3RRPA 2NYFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5F92 A;  3KDY A;  2QGA B;  2O7B A;  3NZ4 A;  4C5S A;  3QBP A;  1B8F A;  3GZH A;  1FUR A;  1GKJ A;  4BAB A;  1KQ7 A;  1J3U A;  1C3U A;  2RJR A;  4C6G A;  4NSL A;  2HVG A;  1Q5N A;  4BAA A;  1TJ7 A;  2PTR A;  2FUS A;  3UNV A;  1VDK A;  1EB4 A;  1FUO A;  1T6P A;  4FLC A;  4APB A;  3NO9 A;  1K62 A;  1YFE A;  1GK3 A;  1TJV A;  3OCF A;  5EYT A;  4NLE A;  3OCE A;  4V2R A;  3BHG A;  3KDZ A;  1DCN A;  3TV2 A;  2X75 A;  1FUQ A;  1FUP A;  2RJS A;  2YII A;  5EYV A;  1W27 A;  1RE5 A;  4EEI A;  1TJU A;  4FFX A;  1U16 A;  2O6Y A;  2O7E A;  5D6B A;  4C5R A;  1T6J A;  3GTD A;  1YFM A;  1DOF A;  3E04 A;  1U15 A;  1I0A A;  1TJW A;  2NYN A;  4ADL A;  5F91 A;  1GKM A;  1K7W A;  2OHY A;  4MX2 A;  4C5U A;  3CZO A;  2PTS A;  3RD8 A;  2PTQ A;  1JSW A;  2QVE A;  1AUW A;  4V2Q A;  1HY1 A;  2J91 A;  5HW2 A;  1YIS A;  4CQ5 A;  4HGV A;  1C3C A;  2E9F A;  3R6V A;  4ADM A;  2O7D A;  4EFC A;  2O7F A;  1Y2M A;  3R6Q A;  4APA A;  1XWO A;  3C8T A;  2O78 A;  1GK2 A;  3R6Y A;  1HY0 A;  2PFM A;  2VD6 A;  3RRP A;  2NYF A; 
#chains in the Genus database with same CATH topology
 2VSF A;  5F92 A;  3KDY A;  2QGA B;  2O7B A;  1HQM D;  3NZ4 A;  4C5S A;  1Y1W A;  3QBP A;  1XL7 A;  3FKI A;  1B8F A;  3GZH A;  1FUR A;  1GKJ A;  4BAB A;  2MP0 A;  1KQ7 A;  1SFO A;  2X0P A;  1J3U A;  1C3U A;  3LR6 A;  3LRD A;  4C6G A;  2LKM B;  3H0G A;  1Q5N A;  4BAA A;  2HVG A;  2RJR A;  4NSL A;  2JA5 A;  1EZA A;  1SMY D;  1TJ7 A;  2PTR A;  2FUS A;  1TWF A;  3UNV A;  1VDK A;  2MX8 A;  1EB4 A;  2YU9 A;  1FUO A;  2R92 A;  2Y0N A;  2N1D B;  1T6P A;  4FLC A;  4APB A;  2FIO A;  3NO9 A;  1K62 A;  5IZ2 A;  3EZB A;  1YFE A;  1GK3 A;  2FEN A;  1TJV A;  2LPJ A;  3OCF A;  2X0Q A;  5EYT A;  2MQA A;  4NLE A;  3OCE A;  4CEJ A;  2A6H D;  4V2R A;  3BHG A;  2EZB A;  2K3N A;  4C2M A;  3KDZ A;  1TWC A;  3CRW 1;  4CEI A;  3GTJ A;  1DCN A;  1WCM A;  3LR2 A;  2X75 A;  3TV2 A;  1FUQ A;  2X0O A;  2AQL A;  1FUP A;  2A6E D;  2JA7 A;  2RJS A;  2YII A;  5EYV A;  1YNN D;  3CRV A;  5M0I A;  1W27 A;  2R93 A;  2MX9 A;  1RE5 A;  3U44 A;  3EZE A;  4EEI A;  1XLY A;  1I6V D;  3GTO A;  1TJU A;  4FFX A;  2HWG A;  1U16 A;  2O7E A;  2O6Y A;  5D6B A;  4C5R A;  2B63 A;  1T6J A;  3GTD A;  2EZC A;  3CQZ A;  1YFM A;  1DOF A;  3E04 A;  2VK9 A;  1TWA A;  1U15 A;  1XMD A;  1I0A A;  3GTP A;  2VL7 A;  1XMC A;  1TJW A;  1K83 A;  2NYN A;  4FBS A;  4ADL A;  3GTQ A;  5F91 A;  3GTK A;  1GKM A;  4WNL A;  1K7W A;  2OHY A;  2K3Q A;  4MX2 A;  4C5U A;  3CZO A;  2PTS A;  2CW0 D;  2JA6 A;  1I50 A;  3RD8 A;  1IW7 D;  2PTQ A;  1JSW A;  2QVE A;  1TWH A;  3U4Q A;  1AUW A;  4V2Q A;  2E2H A;  1HY1 A;  2J91 A;  5HW2 A;  1ZYR D;  2F5J A;  2LPI A;  1YIS A;  4CQ5 A;  2N3E A;  2E2I A;  3GTL A;  1EZB A;  4QIW A;  4HGV A;  1C3C A;  2E9F A;  5M0J A;  2LYI A;  3R6V A;  2EZA A;  1XL8 A;  4ADM A;  2O7D A;  2A68 D;  3EZA A;  4EFC A;  2O7F A;  1Y2M A;  4A15 A;  2A69 D;  3R6Q A;  3LR8 A;  1R9T A;  4APA A;  1ZYM A;  2NVY A;  2LTH A;  2O5J D;  2HRO A;  1XWO A;  3C8T A;  2FIP A;  3GTG A;  5H8W A;  2O78 A;  1TWG A;  1GK2 A;  2BE5 D;  4CEH A;  3R6Y A;  1Y1V A;  2K3O A;  2VUM A;  2NVX A;  1HY0 A;  2FEL A;  1I3Q A;  2PFM A;  2VD6 A;  3GTM A;  3RRP A;  2NYF A;  1YNJ D;  2R7Z A; 
#chains in the Genus database with same CATH homology
 5F92 A;  3KDY A;  2QGA B;  2O7B A;  3NZ4 A;  4C5S A;  3QBP A;  1B8F A;  3GZH A;  1FUR A;  1GKJ A;  4BAB A;  1KQ7 A;  1J3U A;  1C3U A;  2RJR A;  4C6G A;  4NSL A;  2HVG A;  1Q5N A;  4BAA A;  1TJ7 A;  2PTR A;  2FUS A;  3UNV A;  1VDK A;  1EB4 A;  1FUO A;  1T6P A;  4FLC A;  4APB A;  3NO9 A;  1K62 A;  1YFE A;  1GK3 A;  1TJV A;  3OCF A;  5EYT A;  4NLE A;  3OCE A;  4V2R A;  3BHG A;  3KDZ A;  1DCN A;  3TV2 A;  2X75 A;  1FUQ A;  1FUP A;  2RJS A;  2YII A;  5EYV A;  1W27 A;  1RE5 A;  4EEI A;  1TJU A;  4FFX A;  1U16 A;  2O6Y A;  2O7E A;  5D6B A;  4C5R A;  1T6J A;  3GTD A;  1YFM A;  1DOF A;  3E04 A;  1U15 A;  1I0A A;  1TJW A;  2NYN A;  4ADL A;  5F91 A;  1GKM A;  1K7W A;  2OHY A;  4MX2 A;  4C5U A;  3CZO A;  2PTS A;  3RD8 A;  2PTQ A;  1JSW A;  2QVE A;  1AUW A;  4V2Q A;  1HY1 A;  2J91 A;  5HW2 A;  1YIS A;  4CQ5 A;  4HGV A;  1C3C A;  2E9F A;  3R6V A;  4ADM A;  2O7D A;  4EFC A;  2O7F A;  1Y2M A;  3R6Q A;  4APA A;  1XWO A;  3C8T A;  2O78 A;  1GK2 A;  3R6Y A;  1HY0 A;  2PFM A;  2VD6 A;  3RRP A;  2NYF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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