1T6PA

Crystal structure of phenylalanine ammonia lyase from rhodosporidium toruloides
Total Genus 228
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
228
sequence length
687
structure length
653
Chain Sequence
TNLAVAGSHLPTTQVTQVDIVEKMLAAPTDSTLELDGYSLNLGDVVSAARKGRPVRVKDSDEIRSKIDKSVEFLRSEDAISLQKALLEHQLCGVLPSSFDSFRLGRGLENSLPLEVVRGAMTIRVNSLTRGHSAVRLVVLEALTNFLNHGITPIVPLRGTISDLSPLSYIAAAISGHPDSKVHVVHEGKEKILYAREAMALFNLEPVVLGPKEGLGLVNGTAVSASMATLALHDAHMLSLLSQSLTAMTVEAMVGHAGSFHPFLHDVTRPHPTQIEVAGNIRKLLEGSRFAVHHEEQDRYPLRTSPQWLGPLVSDLIHAHAVLTIEAGQSTTDNPLIDVENKTSHHGGNFQAAAVANTMEKTRLGLAQIGKLNFTQLTEMLNAGMNRGLPSCLAAEDPSLSYHCKGLDIAAAAYTSELGHLANPVTTHVQPAEMANQAVNSLALISARRTTESNDVLSLLLATHLYCVLQAIDLRAIEFEFKKQFGPAIVSLIDQHFGSAMTGSNLRDELVEKVNKTLAKRLEQTNSYDLVPRWHDAFSFAAGTVVEVLSSTSLSLAAVNAWKVAAAESAISLTRQVRETFWSAASTSSPALSYLSPRTQILYAFVREELGVKARRGDVFLGKQEVTIGSNVSKIYEAIKSGRINNVLLKMLA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structure of phenylalanine ammonia lyase: multiple helix dipoles implicated in catalysis.
pubmed doi rcsb
source organism Rhodosporidium toruloides
molecule tags Lyase
molecule keywords phenylalanine ammonia-lyase
total genus 228
structure length 653
sequence length 687
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 4.3.1.25: Phenylalanine/tyrosine ammonia-lyase.
pdb deposition date 2004-05-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 1t6pA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1t6pA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1t6pA02
1JSWA 4ADMA 2O6YA 1TJWA 4BABA 1GK3A 2OHYA 5HW2A 1U15A 3R6QA 4C5SA 1YISA 1RE5A 3E04A 1U16A 4NSLA 1FUOA 1TJUA 4APBA 3OCFA 5F91A 1Q5NA 4CQ5A 3GTDA 5EYVA 2HVGA 1K62A 4FFXA 4APAA 2O7EA 1GKMA 1KQ7A 2O7FA 1C3CA 1GK2A 2PTRA 1C3UA 2NYNA 2PTQA 4MX2A 1FUPA 2PFMA 2O78A 1HY0A 2FUSA 1XWOA 4ADLA 1B8FA 5D6BA 4BAAA 1HY1A 2O7BA 3C8TA 4C5UA 3GZHA 3RD8A 2X75A 4V2QA 1YFEA 4NLEA 1K7WA 1DCNA 4EFCA 2RJRA 1W27A 4HGVA 3R6YA 1YFMA 4EEIA 4C5RA 4C6GA 1I0AA 3UNVA 1FUQA 1VDKA 2RJSA 1FURA 1T6PA 1AUWA 1GKJA 1J3UA 3NZ4A 3BHGA 2PTSA 3OCEA 1TJVA 4V2RA 1EB4A 2O7DA 3KDZA 1TJ7A 3QBPA 3RRPA 2VD6A 5F92A 1Y2MA 2J91A 4FLCA 3R6VA 3CZOA 3TV2A 2YIIA 2QGAB 2QVEA 2E9FA 3NO9A 2NYFA 3KDYA 1DOFA 1T6JA 5EYTA
chains in the Genus database with same CATH superfamily
1R9TA 3LR2A 1JSWA 2MX8A 4ADMA 2HROA 2O6YA 2EZAA 2EZBA 1TWAA 2EZCA 1TJWA 4BABA 4CEHA 3EZEA 2FIPA 1GK3A 1U15A 2OHYA 5HW2A 1XMDA 3R6QA 4C5SA 2FIOA 2VSFA 1YISA 1RE5A 2JA7A 3E04A 1U16A 4NSLA 1FUOA 1TWFA 1TJUA 4APBA 2A69D 3OCFA 5F91A 1YNND 3GTQA 4CQ5A 1Q5NA 2N1DB 4WNLA 1YNJD 3GTDA 5EYTA 2LPIA 5EYVA 2HVGA 2FENA 2X0QA 4CEIA 2K3QA 1I3QA 1TWGA 1K62A 2R93A 2A6ED 4FFXA 4APAA 3GTMA 5IZ2A 2Y0NA 1GKMA 1KQ7A 2O7EA 2O7FA 3LR6A 1C3CA 1GK2A 2FELA 3GTKA 2B63A 1EZAA 2PTRA 1C3UA 2NYNA 1I6VD 2PTQA 4MX2A 1FUPA 2N3EA 2PFMA 2NVXA 2O78A 1SMYD 1SFOA 3H0GA 1HQMD 2E2HA 1HY0A 2FUSA 5M0JA 1EZBA 1XWOA 4ADLA 1B8FA 2BE5D 2CW0D 4CEJA 5D6BA 2K3OA 2MQAA 3CQZA 2VK9A 1ZYRD 4BAAA 1HY1A 2O7BA 3U44A 3C8TA 4C5UA 3GZHA 3EZBA 3RD8A 2X75A 4V2QA 1YFEA 4NLEA 1Y1WA 4C2MA 2JA5A 1K7WA 3CRVA 1DCNA 4EFCA 2RJRA 1W27A 1TWCA 4HGVA 3R6YA 1YFMA 4EEIA 4C5RA 4C6GA 3EZAA 2F5JA 1I0AA 3GTPA 2K3NA 1FUQA 3CRW1 3UNVA 2X0PA 2YU9A 3GTGA 2VUMA 3GTOA 1VDKA 2RJSA 1XLYA 1Y1VA 1I50A 1FURA 1T6PA 1AUWA 2MP0A 1IW7D 4QIWA 2R92A 1GKJA 5M0IA 2R7ZA 1J3UA 4A15A 3NZ4A 3BHGA 2LTHA 3FKIA 2X0OA 1K83A 2PTSA 3OCEA 1TWHA 4V2RA 1TJVA 1EB4A 2O7DA 3KDZA 2LYIA 1TJ7A 3QBPA 1WCMA 2NVYA 2E2IA 1XL8A 2LKMB 2VD6A 3RRPA 5F92A 1Y2MA 2J91A 4FLCA 3R6VA 3LR8A 1ZYMA 1XL7A 3CZOA 3LRDA 3TV2A 2YIIA 2JA6A 2O5JD 3GTLA 2VL7A 2QGAB 2QVEA 2E9FA 2AQLA 2MX9A 3NO9A 2A68D 3U4QA 3GTJA 4FBSA 5H8WA 2NYFA 3KDYA 1DOFA 2LPJA 2HWGA 2A6HD 1T6JA 1XMCA
chains in the Genus database with same CATH topology
1JSWA 4ADMA 2O6YA 1TJWA 4BABA 1GK3A 2OHYA 5HW2A 1U15A 3R6QA 4C5SA 1YISA 1RE5A 3E04A 1U16A 4NSLA 1FUOA 1TJUA 4APBA 3OCFA 5F91A 1Q5NA 4CQ5A 3GTDA 5EYVA 2HVGA 1K62A 4FFXA 4APAA 2O7EA 1GKMA 1KQ7A 2O7FA 1C3CA 1GK2A 2PTRA 1C3UA 2NYNA 2PTQA 4MX2A 1FUPA 2PFMA 2O78A 1HY0A 2FUSA 1XWOA 4ADLA 1B8FA 5D6BA 4BAAA 1HY1A 2O7BA 3C8TA 4C5UA 3GZHA 3RD8A 2X75A 4V2QA 1YFEA 4NLEA 1K7WA 1DCNA 4EFCA 2RJRA 1W27A 4HGVA 3R6YA 1YFMA 4EEIA 4C5RA 4C6GA 1I0AA 3UNVA 1FUQA 1VDKA 2RJSA 1FURA 1T6PA 1AUWA 1GKJA 1J3UA 3NZ4A 3BHGA 2PTSA 3OCEA 1TJVA 4V2RA 1EB4A 2O7DA 3KDZA 1TJ7A 3QBPA 3RRPA 2VD6A 5F92A 1Y2MA 2J91A 4FLCA 3R6VA 3CZOA 3TV2A 2YIIA 2QGAB 2QVEA 2E9FA 3NO9A 2NYFA 3KDYA 1DOFA 1T6JA 5EYTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1JSW A;  4ADM A;  2O6Y A;  1TJW A;  4BAB A;  1GK3 A;  2OHY A;  5HW2 A;  1U15 A;  3R6Q A;  4C5S A;  1YIS A;  1RE5 A;  3E04 A;  1U16 A;  4NSL A;  1FUO A;  1TJU A;  4APB A;  3OCF A;  5F91 A;  1Q5N A;  4CQ5 A;  3GTD A;  5EYV A;  2HVG A;  1K62 A;  4FFX A;  4APA A;  2O7E A;  1GKM A;  1KQ7 A;  2O7F A;  1C3C A;  1GK2 A;  2PTR A;  1C3U A;  2NYN A;  2PTQ A;  4MX2 A;  1FUP A;  2PFM A;  2O78 A;  1HY0 A;  2FUS A;  1XWO A;  4ADL A;  1B8F A;  5D6B A;  4BAA A;  1HY1 A;  2O7B A;  3C8T A;  4C5U A;  3GZH A;  3RD8 A;  2X75 A;  4V2Q A;  1YFE A;  4NLE A;  1K7W A;  1DCN A;  4EFC A;  2RJR A;  1W27 A;  4HGV A;  3R6Y A;  1YFM A;  4EEI A;  4C5R A;  4C6G A;  1I0A A;  3UNV A;  1FUQ A;  1VDK A;  2RJS A;  1FUR A;  1T6P A;  1AUW A;  1GKJ A;  1J3U A;  3NZ4 A;  3BHG A;  2PTS A;  3OCE A;  1TJV A;  4V2R A;  1EB4 A;  2O7D A;  3KDZ A;  1TJ7 A;  3QBP A;  3RRP A;  2VD6 A;  5F92 A;  1Y2M A;  2J91 A;  4FLC A;  3R6V A;  3CZO A;  3TV2 A;  2YII A;  2QGA B;  2QVE A;  2E9F A;  3NO9 A;  2NYF A;  3KDY A;  1DOF A;  1T6J A;  5EYT A; 
#chains in the Genus database with same CATH topology
 1R9T A;  3LR2 A;  1JSW A;  2MX8 A;  4ADM A;  2HRO A;  2O6Y A;  2EZA A;  2EZB A;  1TWA A;  2EZC A;  1TJW A;  4BAB A;  4CEH A;  3EZE A;  2FIP A;  1GK3 A;  1U15 A;  2OHY A;  5HW2 A;  1XMD A;  3R6Q A;  4C5S A;  2FIO A;  2VSF A;  1YIS A;  1RE5 A;  2JA7 A;  3E04 A;  1U16 A;  4NSL A;  1FUO A;  1TWF A;  1TJU A;  4APB A;  2A69 D;  3OCF A;  5F91 A;  1YNN D;  3GTQ A;  4CQ5 A;  1Q5N A;  2N1D B;  4WNL A;  1YNJ D;  3GTD A;  5EYT A;  2LPI A;  5EYV A;  2HVG A;  2FEN A;  2X0Q A;  4CEI A;  2K3Q A;  1I3Q A;  1TWG A;  1K62 A;  2R93 A;  2A6E D;  4FFX A;  4APA A;  3GTM A;  5IZ2 A;  2Y0N A;  1GKM A;  1KQ7 A;  2O7E A;  2O7F A;  3LR6 A;  1C3C A;  1GK2 A;  2FEL A;  3GTK A;  2B63 A;  1EZA A;  2PTR A;  1C3U A;  2NYN A;  1I6V D;  2PTQ A;  4MX2 A;  1FUP A;  2N3E A;  2PFM A;  2NVX A;  2O78 A;  1SMY D;  1SFO A;  3H0G A;  1HQM D;  2E2H A;  1HY0 A;  2FUS A;  5M0J A;  1EZB A;  1XWO A;  4ADL A;  1B8F A;  2BE5 D;  2CW0 D;  4CEJ A;  5D6B A;  2K3O A;  2MQA A;  3CQZ A;  2VK9 A;  1ZYR D;  4BAA A;  1HY1 A;  2O7B A;  3U44 A;  3C8T A;  4C5U A;  3GZH A;  3EZB A;  3RD8 A;  2X75 A;  4V2Q A;  1YFE A;  4NLE A;  1Y1W A;  4C2M A;  2JA5 A;  1K7W A;  3CRV A;  1DCN A;  4EFC A;  2RJR A;  1W27 A;  1TWC A;  4HGV A;  3R6Y A;  1YFM A;  4EEI A;  4C5R A;  4C6G A;  3EZA A;  2F5J A;  1I0A A;  3GTP A;  2K3N A;  1FUQ A;  3CRW 1;  3UNV A;  2X0P A;  2YU9 A;  3GTG A;  2VUM A;  3GTO A;  1VDK A;  2RJS A;  1XLY A;  1Y1V A;  1I50 A;  1FUR A;  1T6P A;  1AUW A;  2MP0 A;  1IW7 D;  4QIW A;  2R92 A;  1GKJ A;  5M0I A;  2R7Z A;  1J3U A;  4A15 A;  3NZ4 A;  3BHG A;  2LTH A;  3FKI A;  2X0O A;  1K83 A;  2PTS A;  3OCE A;  1TWH A;  4V2R A;  1TJV A;  1EB4 A;  2O7D A;  3KDZ A;  2LYI A;  1TJ7 A;  3QBP A;  1WCM A;  2NVY A;  2E2I A;  1XL8 A;  2LKM B;  2VD6 A;  3RRP A;  5F92 A;  1Y2M A;  2J91 A;  4FLC A;  3R6V A;  3LR8 A;  1ZYM A;  1XL7 A;  3CZO A;  3LRD A;  3TV2 A;  2YII A;  2JA6 A;  2O5J D;  3GTL A;  2VL7 A;  2QGA B;  2QVE A;  2E9F A;  2AQL A;  2MX9 A;  3NO9 A;  2A68 D;  3U4Q A;  3GTJ A;  4FBS A;  5H8W A;  2NYF A;  3KDY A;  1DOF A;  2LPJ A;  2HWG A;  2A6H D;  1T6J A;  1XMC A; 
#chains in the Genus database with same CATH homology
 1JSW A;  4ADM A;  2O6Y A;  1TJW A;  4BAB A;  1GK3 A;  2OHY A;  5HW2 A;  1U15 A;  3R6Q A;  4C5S A;  1YIS A;  1RE5 A;  3E04 A;  1U16 A;  4NSL A;  1FUO A;  1TJU A;  4APB A;  3OCF A;  5F91 A;  1Q5N A;  4CQ5 A;  3GTD A;  5EYV A;  2HVG A;  1K62 A;  4FFX A;  4APA A;  2O7E A;  1GKM A;  1KQ7 A;  2O7F A;  1C3C A;  1GK2 A;  2PTR A;  1C3U A;  2NYN A;  2PTQ A;  4MX2 A;  1FUP A;  2PFM A;  2O78 A;  1HY0 A;  2FUS A;  1XWO A;  4ADL A;  1B8F A;  5D6B A;  4BAA A;  1HY1 A;  2O7B A;  3C8T A;  4C5U A;  3GZH A;  3RD8 A;  2X75 A;  4V2Q A;  1YFE A;  4NLE A;  1K7W A;  1DCN A;  4EFC A;  2RJR A;  1W27 A;  4HGV A;  3R6Y A;  1YFM A;  4EEI A;  4C5R A;  4C6G A;  1I0A A;  3UNV A;  1FUQ A;  1VDK A;  2RJS A;  1FUR A;  1T6P A;  1AUW A;  1GKJ A;  1J3U A;  3NZ4 A;  3BHG A;  2PTS A;  3OCE A;  1TJV A;  4V2R A;  1EB4 A;  2O7D A;  3KDZ A;  1TJ7 A;  3QBP A;  3RRP A;  2VD6 A;  5F92 A;  1Y2M A;  2J91 A;  4FLC A;  3R6V A;  3CZO A;  3TV2 A;  2YII A;  2QGA B;  2QVE A;  2E9F A;  3NO9 A;  2NYF A;  3KDY A;  1DOF A;  1T6J A;  5EYT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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