1T7DA

Crystal structure of escherichia coli type i signal peptidase in complex with a lipopeptide inhibitor
Total Genus 47
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
47
sequence length
244
structure length
208
Chain Sequence
IYEPFQIPSGSMMPTLLIGDFILVEKFHPKRGDIVVFKYPEDPKLDYIKRAVGLPGDKVTYDPVSKELTIQPGCNALPVTYSNVEPSDFVQTFSRREATSGFFEVPKNETKENGIRLSERKETLGDVTHRILTVPIAQDQVGMYYQQPGQQLATWIVPPGQYFMMGDNRDNSADSRYWGFVPEANLVGRATAIWMSFDLRLSRIGGIH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystallographic and Biophysical Analysis of a Bacterial Signal Peptidase in Complex with a Lipopeptide Based Inhibitor.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase/antibiotic
molecule keywords SIGNAL PEPTIDASE I
total genus 47
structure length 208
sequence length 244
chains with identical sequence B
ec nomenclature ec 3.4.21.89: Signal peptidase I.
pdb deposition date 2004-05-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00717 Peptidase_S24 Peptidase S24-like
A PF10502 Peptidase_S26 Signal peptidase, peptidase S26
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.109.10 Mainly Beta Ribbon Umud Fragment, subunit A Umud Fragment, subunit A 1t7dA01
2.170.230.10 Mainly Beta Beta Complex Signal Peptidase I; Chain: A, domain 2 Signal Peptidase I; Chain: A, domain 2 1t7dA02
4NV4A 1JHFA 1KN9A 1I4VA 2FKDA 2FJRA 4N31A 3K2ZA 3IIQA 1JHCA 4K8WA 2HO0A 2HNFA 3JSPA 1F39A 1T7DA 1KCAA 4ME8A 1JHEA 1UMUA 3BDNA 1JHHA 1B12A 3S04A 1AY9A 3JSOA
chains in the Genus database with same CATH superfamily
4NV4A 1JHFA 1KN9A 1I4VA 2FKDA 2FJRA 4N31A 3K2ZA 3IIQA 1JHCA 4K8WA 2HO0A 2HNFA 3JSPA 1F39A 1T7DA 1KCAA 4ME8A 1JHEA 1UMUA 3BDNA 1JHHA 1B12A 3S04A 1AY9A 3JSOA
chains in the Genus database with same CATH topology
4NV4A 1JHFA 1KN9A 1I4VA 2FKDA 2FJRA 4N31A 3K2ZA 3IIQA 1JHCA 4K8WA 2HO0A 2HNFA 3JSPA 1F39A 1T7DA 1KCAA 4ME8A 1JHEA 1UMUA 3BDNA 1JHHA 1B12A 3S04A 1AY9A 3JSOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4NV4 A;  1JHF A;  1KN9 A;  1I4V A;  2FKD A;  2FJR A;  4N31 A;  3K2Z A;  3IIQ A;  1JHC A;  4K8W A;  2HO0 A;  2HNF A;  3JSP A;  1F39 A;  1T7D A;  1KCA A;  4ME8 A;  1JHE A;  1UMU A;  3BDN A;  1JHH A;  1B12 A;  3S04 A;  1AY9 A;  3JSO A; 
#chains in the Genus database with same CATH topology
 4NV4 A;  1JHF A;  1KN9 A;  1I4V A;  2FKD A;  2FJR A;  4N31 A;  3K2Z A;  3IIQ A;  1JHC A;  4K8W A;  2HO0 A;  2HNF A;  3JSP A;  1F39 A;  1T7D A;  1KCA A;  4ME8 A;  1JHE A;  1UMU A;  3BDN A;  1JHH A;  1B12 A;  3S04 A;  1AY9 A;  3JSO A; 
#chains in the Genus database with same CATH homology
 4NV4 A;  1JHF A;  1KN9 A;  1I4V A;  2FKD A;  2FJR A;  4N31 A;  3K2Z A;  3IIQ A;  1JHC A;  4K8W A;  2HO0 A;  2HNF A;  3JSP A;  1F39 A;  1T7D A;  1KCA A;  4ME8 A;  1JHE A;  1UMU A;  3BDN A;  1JHH A;  1B12 A;  3S04 A;  1AY9 A;  3JSO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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