1TCOA

Ternary complex of a calcineurin a fragment, calcineurin b, fkbp12 and the immunosuppressant drug fk506 (tacrolimus)
Total Genus 126
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
126
sequence length
352
structure length
352
Chain Sequence
b'VPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEETVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNIC'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex.
pubmed doi rcsb
molecule keywords SERINE/THREONINE PHOSPHATASE B2
source organism Bos taurus
molecule tags Complex (hydrolase/isomerase)
total genus 126
structure length 352
sequence length 352
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 1996-08-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 1tcoA00
1WAO1 5INBA 2P6BA 2QFPA 3H64A 1QHWA 1OI8A 1S3NA 4O4KA 4WWLA 5HPEA 2HY1A 4ORBA 4ZX2A 2WDDA 2Z72A 2QFRA 4M0VA 2GJUA 5GTUA 2NYLC 3C5WC 3H68A 3PSNA 4MOVA 4B2OA 4DHLA 1JK7A 2CV9A 2Z1AA 3E7BA 1TCOA 2BDXA 2BCDA 2DFJA 4FBKA 4O24A 1MF8A 4Q7FA 3H69A 3CK2A 3H60A 3QFNA 3EGHA 2HYPA 1UTEA 4UT2A 4NZVA 1HP1A 4LU9A 1QFCA 4FCXA 4YKEA 4UWQA 2IE4C 4DT2A 4MP0A 2O8AA 3RL4A 4HD0A 3LL8A 4TUIA 1V73A 3DSCA 3AUZA 3AV0A 1UF3A 4V0WA 3T1IA 3RQZA 3H66A 1G5BA 5F3WA 4XPNA 3ZU0A 1W24A 1T70A 3QG5C 1IT6A 2WDEA 1S95A 4H2BA 4IYPC 4H2IA 4DSYA 4O43A 3K7VC 1S3MA 3EGGA 3PSOA 1Z2WA 1OIDA 1OIEA 3HVQA 3JYFA 5JJTA 1SU1A 1WARA 2NYMC 1XZWA 3GVEA 4JA9A 1M63A 2IE3C 5EQVA 4J6OA 1HO5A 4TUGA 4FBQA 1U32A 3IVEA 5DNYA 3H62B 3TGHA 1T71A 1S70A 1FJMA 5JPEA 4JA7A 3KBPA 3RL3A 3QFMA 4FBWA 3C9FA 3ICFA 2R17A 3ZTVA 4MOYA 2NXFA 4G9JA 2Z06A 3V4YA 4V0XA 2O8GA 2JOGA 4H2FA 2WDFA 3IB7A 2A22A 2YVTA 2BQ8X 5C1VA 3THNA 3H67A 3DW8C 3QFKA 4F0ZA 1S3LA 2WDCA 3QFOA 4ORAA 3RL5A 5JPFA 2HYOA 1AUIA 1XM7A 3H61A 4LTYA 2IAEC 2Q8UA 3FGAC 3P71C 2USHA 5B8IA 1Z2XA 3IVDA 1HPUA 2XMOA 5IOHA 1USHA 4UT3B 3N5UA 4KKZA 4KBPA 2ZBMA 4ZVZA 4OR9A 2KKNA 1KBPA 2AHDA 4O5GA 3E7AA 4IL1A 2NPPC 3H63A 3IB8A 4H1YP 4V0VA 4H1SA 4LACC 5J28A 3DSDA 4I5LC 2QJCA 4ORCA 4H2GA 3K7WC 1NNWA 4I5NC 1II7A 4UT3A 1S8EA 3THOB
chains in the Genus database with same CATH superfamily
1WAO1 5INBA 2P6BA 2QFPA 3H64A 1QHWA 1OI8A 1S3NA 4O4KA 4WWLA 5HPEA 2HY1A 4ORBA 4ZX2A 2WDDA 2Z72A 2QFRA 4M0VA 2GJUA 5GTUA 2NYLC 3C5WC 3H68A 3PSNA 4MOVA 4B2OA 4DHLA 1JK7A 2CV9A 2Z1AA 3E7BA 3E0JA 1TCOA 2BDXA 2BCDA 2DFJA 4FBKA 4O24A 1MF8A 4Q7FA 3H69A 3CK2A 3H60A 3QFNA 3EGHA 2HYPA 1UTEA 4UT2A 4NZVA 1HP1A 4LU9A 1QFCA 4FCXA 4YKEA 4UWQA 2IE4C 4DT2A 4MP0A 2O8AA 3RL4A 4HD0A 3LL8A 4TUIA 1V73A 3DSCA 3AUZA 3AV0A 1UF3A 4V0WA 3T1IA 3RQZA 3H66A 1G5BA 5F3WA 4XPNA 3ZU0A 1W24A 3D03A 1T70A 3QG5C 1IT6A 2WDEA 1S95A 4H2BA 4IYPC 4H2IA 4DSYA 4O43A 3K7VC 1S3MA 3EGGA 3PSOA 1Z2WA 1OIDA 1OIEA 3HVQA 3JYFA 5JJTA 1SU1A 1WARA 2NYMC 1XZWA 3GVEA 4JA9A 1M63A 2IE3C 5EQVA 4J6OA 1HO5A 4TUGA 4FBQA 1U32A 3IVEA 5DNYA 3H62B 2ZO9B 2YEQA 3TGHA 1T71A 1S70A 1FJMA 5JPEA 4JA7A 3KBPA 3RL3A 3QFMA 4FBWA 3C9FA 3ICFA 2R17A 3ZTVA 2DXNA 2ZOAA 4MOYA 2NXFA 4G9JA 2Z06A 3V4YA 4V0XA 2O8GA 2JOGA 4H2FA 2WDFA 3IB7A 2A22A 2YVTA 2BQ8X 5C1VA 3THNA 3H67A 3DW8C 3QFKA 4F0ZA 1S3LA 2WDCA 3QFOA 4ORAA 3RL5A 5JPFA 2HYOA 1AUIA 1XM7A 3H61A 4LTYA 2IAEC 2Q8UA 3FGAC 3P71C 2USHA 5B8IA 1Z2XA 3IVDA 3FLOA 1HPUA 2XMOA 5IOHA 1USHA 4UT3B 3N5UA 4KKZA 4KBPA 2ZBMA 4ZVZA 4OR9A 2KKNA 1KBPA 2AHDA 4O5GA 3E7AA 4IL1A 2DXLA 2NPPC 3H63A 3IB8A 4H1YP 4V0VA 4H1SA 4LACC 5J28A 3DSDA 4I5LC 2QJCA 4ORCA 4H2GA 3K7WC 1NNWA 4I5NC 1II7A 4UT3A 1S8EA 3THOB
chains in the Genus database with same CATH topology
1WAO1 5INBA 2P6BA 2QFPA 3H64A 1QHWA 1OI8A 1S3NA 4O4KA 4WWLA 5HPEA 2HY1A 4ORBA 4ZX2A 2WDDA 2Z72A 2QFRA 4M0VA 2GJUA 5GTUA 2NYLC 3C5WC 3H68A 3PSNA 4MOVA 4B2OA 4DHLA 1JK7A 2CV9A 2Z1AA 3E7BA 3E0JA 1TCOA 2BDXA 2BCDA 2DFJA 4FBKA 4O24A 1MF8A 4Q7FA 3H69A 3CK2A 3H60A 3QFNA 3EGHA 2HYPA 1UTEA 4UT2A 4NZVA 1HP1A 4LU9A 1QFCA 4FCXA 4YKEA 4UWQA 2IE4C 4DT2A 4MP0A 2O8AA 3RL4A 4HD0A 3LL8A 4TUIA 1V73A 3DSCA 3AUZA 3AV0A 1UF3A 4V0WA 3T1IA 3RQZA 3H66A 1G5BA 5F3WA 4XPNA 3ZU0A 1W24A 3D03A 1T70A 3QG5C 1IT6A 2WDEA 1S95A 4H2BA 4IYPC 4H2IA 4DSYA 4O43A 3K7VC 1S3MA 3EGGA 3PSOA 1Z2WA 1OIDA 1OIEA 3HVQA 3JYFA 5JJTA 1SU1A 1WARA 2NYMC 1XZWA 3GVEA 4JA9A 1M63A 2IE3C 5EQVA 4J6OA 1HO5A 4TUGA 4FBQA 1U32A 3IVEA 5DNYA 3H62B 2ZO9B 2YEQA 3TGHA 1T71A 1S70A 1FJMA 5JPEA 4JA7A 3KBPA 3RL3A 3QFMA 4FBWA 3C9FA 3ICFA 2R17A 3ZTVA 2DXNA 2ZOAA 4MOYA 2NXFA 4G9JA 2Z06A 3V4YA 4V0XA 2O8GA 2JOGA 4H2FA 2WDFA 3IB7A 2A22A 2YVTA 2BQ8X 5C1VA 3THNA 3H67A 3DW8C 3QFKA 4F0ZA 1S3LA 2WDCA 3QFOA 4ORAA 3RL5A 5JPFA 2HYOA 1AUIA 1XM7A 3H61A 4LTYA 2IAEC 2Q8UA 3FGAC 3P71C 2USHA 5B8IA 1Z2XA 3IVDA 3FLOA 1HPUA 2XMOA 5IOHA 1USHA 4UT3B 3N5UA 4KKZA 4KBPA 2ZBMA 4ZVZA 4OR9A 2KKNA 1KBPA 2AHDA 4O5GA 3E7AA 4IL1A 2DXLA 2NPPC 3H63A 3IB8A 4H1YP 4V0VA 4H1SA 4LACC 5J28A 3DSDA 4I5LC 2QJCA 4ORCA 4H2GA 3K7WC 1NNWA 4I5NC 1II7A 4UT3A 1S8EA 3THOB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WAO 1;  5INB A;  2P6B A;  2QFP A;  3H64 A;  1QHW A;  1OI8 A;  1S3N A;  4O4K A;  4WWL A;  5HPE A;  2HY1 A;  4ORB A;  4ZX2 A;  2WDD A;  2Z72 A;  2QFR A;  4M0V A;  2GJU A;  5GTU A;  2NYL C;  3C5W C;  3H68 A;  3PSN A;  4MOV A;  4B2O A;  4DHL A;  1JK7 A;  2CV9 A;  2Z1A A;  3E7B A;  1TCO A;  2BDX A;  2BCD A;  2DFJ A;  4FBK A;  4O24 A;  1MF8 A;  4Q7F A;  3H69 A;  3CK2 A;  3H60 A;  3QFN A;  3EGH A;  2HYP A;  1UTE A;  4UT2 A;  4NZV A;  1HP1 A;  4LU9 A;  1QFC A;  4FCX A;  4YKE A;  4UWQ A;  2IE4 C;  4DT2 A;  4MP0 A;  2O8A A;  3RL4 A;  4HD0 A;  3LL8 A;  4TUI A;  1V73 A;  3DSC A;  3AUZ A;  3AV0 A;  1UF3 A;  4V0W A;  3T1I A;  3RQZ A;  3H66 A;  1G5B A;  5F3W A;  4XPN A;  3ZU0 A;  1W24 A;  1T70 A;  3QG5 C;  1IT6 A;  2WDE A;  1S95 A;  4H2B A;  4IYP C;  4H2I A;  4DSY A;  4O43 A;  3K7V C;  1S3M A;  3EGG A;  3PSO A;  1Z2W A;  1OID A;  1OIE A;  3HVQ A;  3JYF A;  5JJT A;  1SU1 A;  1WAR A;  2NYM C;  1XZW A;  3GVE A;  4JA9 A;  1M63 A;  2IE3 C;  5EQV A;  4J6O A;  1HO5 A;  4TUG A;  4FBQ A;  1U32 A;  3IVE A;  5DNY A;  3H62 B;  3TGH A;  1T71 A;  1S70 A;  1FJM A;  5JPE A;  4JA7 A;  3KBP A;  3RL3 A;  3QFM A;  4FBW A;  3C9F A;  3ICF A;  2R17 A;  3ZTV A;  4MOY A;  2NXF A;  4G9J A;  2Z06 A;  3V4Y A;  4V0X A;  2O8G A;  2JOG A;  4H2F A;  2WDF A;  3IB7 A;  2A22 A;  2YVT A;  2BQ8 X;  5C1V A;  3THN A;  3H67 A;  3DW8 C;  3QFK A;  4F0Z A;  1S3L A;  2WDC A;  3QFO A;  4ORA A;  3RL5 A;  5JPF A;  2HYO A;  1AUI A;  1XM7 A;  3H61 A;  4LTY A;  2IAE C;  2Q8U A;  3FGA C;  3P71 C;  2USH A;  5B8I A;  1Z2X A;  3IVD A;  1HPU A;  2XMO A;  5IOH A;  1USH A;  4UT3 B;  3N5U A;  4KKZ A;  4KBP A;  2ZBM A;  4ZVZ A;  4OR9 A;  2KKN A;  1KBP A;  2AHD A;  4O5G A;  3E7A A;  4IL1 A;  2NPP C;  3H63 A;  3IB8 A;  4H1Y P;  4V0V A;  4H1S A;  4LAC C;  5J28 A;  3DSD A;  4I5L C;  2QJC A;  4ORC A;  4H2G A;  3K7W C;  1NNW A;  4I5N C;  1II7 A;  4UT3 A;  1S8E A;  3THO B; 
#chains in the Genus database with same CATH topology
 1WAO 1;  5INB A;  2P6B A;  2QFP A;  3H64 A;  1QHW A;  1OI8 A;  1S3N A;  4O4K A;  4WWL A;  5HPE A;  2HY1 A;  4ORB A;  4ZX2 A;  2WDD A;  2Z72 A;  2QFR A;  4M0V A;  2GJU A;  5GTU A;  2NYL C;  3C5W C;  3H68 A;  3PSN A;  4MOV A;  4B2O A;  4DHL A;  1JK7 A;  2CV9 A;  2Z1A A;  3E7B A;  3E0J A;  1TCO A;  2BDX A;  2BCD A;  2DFJ A;  4FBK A;  4O24 A;  1MF8 A;  4Q7F A;  3H69 A;  3CK2 A;  3H60 A;  3QFN A;  3EGH A;  2HYP A;  1UTE A;  4UT2 A;  4NZV A;  1HP1 A;  4LU9 A;  1QFC A;  4FCX A;  4YKE A;  4UWQ A;  2IE4 C;  4DT2 A;  4MP0 A;  2O8A A;  3RL4 A;  4HD0 A;  3LL8 A;  4TUI A;  1V73 A;  3DSC A;  3AUZ A;  3AV0 A;  1UF3 A;  4V0W A;  3T1I A;  3RQZ A;  3H66 A;  1G5B A;  5F3W A;  4XPN A;  3ZU0 A;  1W24 A;  3D03 A;  1T70 A;  3QG5 C;  1IT6 A;  2WDE A;  1S95 A;  4H2B A;  4IYP C;  4H2I A;  4DSY A;  4O43 A;  3K7V C;  1S3M A;  3EGG A;  3PSO A;  1Z2W A;  1OID A;  1OIE A;  3HVQ A;  3JYF A;  5JJT A;  1SU1 A;  1WAR A;  2NYM C;  1XZW A;  3GVE A;  4JA9 A;  1M63 A;  2IE3 C;  5EQV A;  4J6O A;  1HO5 A;  4TUG A;  4FBQ A;  1U32 A;  3IVE A;  5DNY A;  3H62 B;  2ZO9 B;  2YEQ A;  3TGH A;  1T71 A;  1S70 A;  1FJM A;  5JPE A;  4JA7 A;  3KBP A;  3RL3 A;  3QFM A;  4FBW A;  3C9F A;  3ICF A;  2R17 A;  3ZTV A;  2DXN A;  2ZOA A;  4MOY A;  2NXF A;  4G9J A;  2Z06 A;  3V4Y A;  4V0X A;  2O8G A;  2JOG A;  4H2F A;  2WDF A;  3IB7 A;  2A22 A;  2YVT A;  2BQ8 X;  5C1V A;  3THN A;  3H67 A;  3DW8 C;  3QFK A;  4F0Z A;  1S3L A;  2WDC A;  3QFO A;  4ORA A;  3RL5 A;  5JPF A;  2HYO A;  1AUI A;  1XM7 A;  3H61 A;  4LTY A;  2IAE C;  2Q8U A;  3FGA C;  3P71 C;  2USH A;  5B8I A;  1Z2X A;  3IVD A;  3FLO A;  1HPU A;  2XMO A;  5IOH A;  1USH A;  4UT3 B;  3N5U A;  4KKZ A;  4KBP A;  2ZBM A;  4ZVZ A;  4OR9 A;  2KKN A;  1KBP A;  2AHD A;  4O5G A;  3E7A A;  4IL1 A;  2DXL A;  2NPP C;  3H63 A;  3IB8 A;  4H1Y P;  4V0V A;  4H1S A;  4LAC C;  5J28 A;  3DSD A;  4I5L C;  2QJC A;  4ORC A;  4H2G A;  3K7W C;  1NNW A;  4I5N C;  1II7 A;  4UT3 A;  1S8E A;  3THO B; 
#chains in the Genus database with same CATH homology
 1WAO 1;  5INB A;  2P6B A;  2QFP A;  3H64 A;  1QHW A;  1OI8 A;  1S3N A;  4O4K A;  4WWL A;  5HPE A;  2HY1 A;  4ORB A;  4ZX2 A;  2WDD A;  2Z72 A;  2QFR A;  4M0V A;  2GJU A;  5GTU A;  2NYL C;  3C5W C;  3H68 A;  3PSN A;  4MOV A;  4B2O A;  4DHL A;  1JK7 A;  2CV9 A;  2Z1A A;  3E7B A;  3E0J A;  1TCO A;  2BDX A;  2BCD A;  2DFJ A;  4FBK A;  4O24 A;  1MF8 A;  4Q7F A;  3H69 A;  3CK2 A;  3H60 A;  3QFN A;  3EGH A;  2HYP A;  1UTE A;  4UT2 A;  4NZV A;  1HP1 A;  4LU9 A;  1QFC A;  4FCX A;  4YKE A;  4UWQ A;  2IE4 C;  4DT2 A;  4MP0 A;  2O8A A;  3RL4 A;  4HD0 A;  3LL8 A;  4TUI A;  1V73 A;  3DSC A;  3AUZ A;  3AV0 A;  1UF3 A;  4V0W A;  3T1I A;  3RQZ A;  3H66 A;  1G5B A;  5F3W A;  4XPN A;  3ZU0 A;  1W24 A;  3D03 A;  1T70 A;  3QG5 C;  1IT6 A;  2WDE A;  1S95 A;  4H2B A;  4IYP C;  4H2I A;  4DSY A;  4O43 A;  3K7V C;  1S3M A;  3EGG A;  3PSO A;  1Z2W A;  1OID A;  1OIE A;  3HVQ A;  3JYF A;  5JJT A;  1SU1 A;  1WAR A;  2NYM C;  1XZW A;  3GVE A;  4JA9 A;  1M63 A;  2IE3 C;  5EQV A;  4J6O A;  1HO5 A;  4TUG A;  4FBQ A;  1U32 A;  3IVE A;  5DNY A;  3H62 B;  2ZO9 B;  2YEQ A;  3TGH A;  1T71 A;  1S70 A;  1FJM A;  5JPE A;  4JA7 A;  3KBP A;  3RL3 A;  3QFM A;  4FBW A;  3C9F A;  3ICF A;  2R17 A;  3ZTV A;  2DXN A;  2ZOA A;  4MOY A;  2NXF A;  4G9J A;  2Z06 A;  3V4Y A;  4V0X A;  2O8G A;  2JOG A;  4H2F A;  2WDF A;  3IB7 A;  2A22 A;  2YVT A;  2BQ8 X;  5C1V A;  3THN A;  3H67 A;  3DW8 C;  3QFK A;  4F0Z A;  1S3L A;  2WDC A;  3QFO A;  4ORA A;  3RL5 A;  5JPF A;  2HYO A;  1AUI A;  1XM7 A;  3H61 A;  4LTY A;  2IAE C;  2Q8U A;  3FGA C;  3P71 C;  2USH A;  5B8I A;  1Z2X A;  3IVD A;  3FLO A;  1HPU A;  2XMO A;  5IOH A;  1USH A;  4UT3 B;  3N5U A;  4KKZ A;  4KBP A;  2ZBM A;  4ZVZ A;  4OR9 A;  2KKN A;  1KBP A;  2AHD A;  4O5G A;  3E7A A;  4IL1 A;  2DXL A;  2NPP C;  3H63 A;  3IB8 A;  4H1Y P;  4V0V A;  4H1S A;  4LAC C;  5J28 A;  3DSD A;  4I5L C;  2QJC A;  4ORC A;  4H2G A;  3K7W C;  1NNW A;  4I5N C;  1II7 A;  4UT3 A;  1S8E A;  3THO B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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