1TCOA

Ternary complex of a calcineurin a fragment, calcineurin b, fkbp12 and the immunosuppressant drug fk506 (tacrolimus)
Total Genus 126
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
126
sequence length
352
structure length
352
Chain Sequence
VPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEETVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNIC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Complex (hydrolase/isomerase)
molecule keywords SERINE/THREONINE PHOSPHATASE B2
publication title X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex.
pubmed doi rcsb
source organism Bos taurus
total genus 126
structure length 352
sequence length 352
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 1996-08-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 1tcoA00
3P71C 1HPUA 3JYFA 4OR9A 2ZBMA 1KBPA 4FCXA 4LTYA 4Q7FA 4UWQA 5C1VA 2DFJA 2QFPA 1II7A 3LL8A 1S8EA 3HVQA 1S3LA 4G9JA 4FBKA 2NXFA 4F0ZA 1XZWA 1WARA 4H2FA 3H66A 1MF8A 3AUZA 4IL1A 2Z72A 3H64A 4FBQA 4FBWA 4O43A 1FJMA 4ZX2A 3GVEA 1M63A 3CK2A 1U32A 1QHWA 3RQZA 4ZVZA 1NNWA 3ICFA 4UT2A 4H1SA 1WAO1 2NPPC 3QFOA 4H2GA 3EGHA 1XM7A 4MP0A 4WWLA 2QFRA 3T1IA 3RL3A 3PSOA 3K7VC 2BQ8X 1T71A 3FGAC 4DT2A 2HYOA 5INBA 5GTUA 1V73A 2R17A 4UT3B 4M0VA 5HPEA 3H60A 4J6OA 2WDCA 2YVTA 2USHA 4H2IA 4ORAA 5JJTA 5JPEA 2BDXA 2QJCA 4O24A 4O5GA 1OIDA 4JA9A 2A22A 1G5BA 5IOHA 2WDFA 2IE3C 4LACC 3H63A 4O4KA 3H69A 4I5LC 5EQVA 2WDDA 4MOVA 3KBPA 1Z2WA 3ZTVA 1SU1A 4XPNA 3DW8C 4H1YP 3RL4A 1S3MA 4KKZA 1IT6A 1HO5A 2Z1AA 5B8IA 4ORCA 4HD0A 2JOGA 2P6BA 1AUIA 3H67A 3IVEA 4V0XA 3TGHA 3DSCA 1JK7A 2XMOA 2GJUA 4ORBA 2CV9A 1W24A 4DHLA 3IVDA 3QFNA 4DSYA 3AV0A 2O8AA 3IB8A 2NYMC 1T70A 4V0VA 4TUGA 3THNA 1HP1A 1S95A 3QG5C 2AHDA 3N5UA 3C5WC 4LU9A 2Z06A 2IAEC 2HY1A 3THOB 3DSDA 5J28A 4NZVA 4JA7A 5JPFA 5F3WA 2WDEA 4IYPC 4B2OA 5DNYA 3QFMA 3IB7A 4I5NC 1Z2XA 2O8GA 3PSNA 1S3NA 3RL5A 3H68A 3K7WC 3EGGA 3ZU0A 2NYLC 2Q8UA 3E7AA 3V4YA 1QFCA 4V0WA 1S70A 3QFKA 4KBPA 3E7BA 1OI8A 1UF3A 1UTEA 1USHA 2KKNA 3H61A 1OIEA 4H2BA 2HYPA 3C9FA 1TCOA 2IE4C 2BCDA 4MOYA 4UT3A 4TUIA 4YKEA 3H62B
chains in the Genus database with same CATH superfamily
3P71C 1HPUA 3JYFA 4OR9A 2ZBMA 1KBPA 4FCXA 4LTYA 4Q7FA 4UWQA 5C1VA 2DFJA 2QFPA 1II7A 3LL8A 1S8EA 3HVQA 1S3LA 4G9JA 4FBKA 2NXFA 4F0ZA 1XZWA 1WARA 2DXLA 4H2FA 3H66A 1MF8A 3AUZA 4IL1A 2Z72A 3H64A 4FBQA 4FBWA 4O43A 1FJMA 4ZX2A 3GVEA 1M63A 3CK2A 1U32A 1QHWA 3RQZA 4ZVZA 1NNWA 3ICFA 4UT2A 4H1SA 1WAO1 2NPPC 3QFOA 4H2GA 3EGHA 1XM7A 4MP0A 4WWLA 2QFRA 3D03A 3T1IA 3RL3A 3PSOA 3K7VC 2BQ8X 1T71A 2ZOAA 3FGAC 4DT2A 2HYOA 5INBA 5GTUA 1V73A 2R17A 4UT3B 4M0VA 5HPEA 3H60A 4J6OA 2WDCA 2YVTA 2USHA 4H2IA 4ORAA 5JJTA 5JPEA 2BDXA 2QJCA 4O24A 4O5GA 1OIDA 4JA9A 2A22A 1G5BA 5IOHA 2WDFA 2IE3C 4LACC 3H63A 4O4KA 3H69A 4I5LC 2ZO9B 5EQVA 2DXNA 2WDDA 3KBPA 4MOVA 1Z2WA 3ZTVA 1SU1A 4XPNA 3DW8C 4H1YP 3RL4A 1S3MA 3E0JA 4KKZA 1IT6A 1HO5A 2Z1AA 5B8IA 4ORCA 4HD0A 2JOGA 2P6BA 1AUIA 3H67A 3IVEA 4V0XA 3TGHA 3DSCA 1JK7A 2XMOA 2GJUA 4ORBA 2CV9A 1W24A 4DHLA 3IVDA 3QFNA 4DSYA 3AV0A 2O8AA 3IB8A 2NYMC 1T70A 4V0VA 3FLOA 4TUGA 3THNA 1HP1A 1S95A 3QG5C 2AHDA 3N5UA 3C5WC 4LU9A 2Z06A 2IAEC 2HY1A 3THOB 3DSDA 5J28A 4NZVA 4JA7A 5JPFA 5F3WA 2WDEA 4IYPC 4B2OA 5DNYA 3QFMA 3IB7A 4I5NC 1Z2XA 2O8GA 3PSNA 1S3NA 2YEQA 3H68A 3RL5A 3K7WC 3EGGA 3ZU0A 2NYLC 2Q8UA 3E7AA 3V4YA 1QFCA 4V0WA 1S70A 3QFKA 4KBPA 3E7BA 1OI8A 1UF3A 1UTEA 1USHA 2KKNA 3H61A 1OIEA 4H2BA 2HYPA 3C9FA 1TCOA 2IE4C 2BCDA 4MOYA 4UT3A 4TUIA 4YKEA 3H62B
chains in the Genus database with same CATH topology
3P71C 1HPUA 3JYFA 4OR9A 2ZBMA 1KBPA 4FCXA 4LTYA 4Q7FA 4UWQA 5C1VA 2DFJA 2QFPA 1II7A 3LL8A 1S8EA 3HVQA 1S3LA 4G9JA 4FBKA 2NXFA 4F0ZA 1XZWA 1WARA 2DXLA 4H2FA 3H66A 1MF8A 3AUZA 4IL1A 2Z72A 3H64A 4FBQA 4FBWA 4O43A 1FJMA 4ZX2A 3GVEA 1M63A 3CK2A 1U32A 1QHWA 3RQZA 4ZVZA 1NNWA 3ICFA 4UT2A 4H1SA 1WAO1 2NPPC 3QFOA 4H2GA 3EGHA 1XM7A 4MP0A 4WWLA 2QFRA 3D03A 3T1IA 3RL3A 3PSOA 3K7VC 2BQ8X 1T71A 2ZOAA 3FGAC 4DT2A 2HYOA 5INBA 5GTUA 1V73A 2R17A 4UT3B 4M0VA 5HPEA 3H60A 4J6OA 2WDCA 2YVTA 2USHA 4H2IA 4ORAA 5JJTA 5JPEA 2BDXA 2QJCA 4O24A 4O5GA 1OIDA 4JA9A 2A22A 1G5BA 5IOHA 2WDFA 2IE3C 4LACC 3H63A 4O4KA 3H69A 4I5LC 2ZO9B 5EQVA 2DXNA 2WDDA 3KBPA 4MOVA 1Z2WA 3ZTVA 1SU1A 4XPNA 3DW8C 4H1YP 3RL4A 1S3MA 3E0JA 4KKZA 1IT6A 1HO5A 2Z1AA 5B8IA 4ORCA 4HD0A 2JOGA 2P6BA 1AUIA 3H67A 3IVEA 4V0XA 3TGHA 3DSCA 1JK7A 2XMOA 2GJUA 4ORBA 2CV9A 1W24A 4DHLA 3IVDA 3QFNA 4DSYA 3AV0A 2O8AA 3IB8A 2NYMC 1T70A 4V0VA 3FLOA 4TUGA 3THNA 1HP1A 1S95A 3QG5C 2AHDA 3N5UA 3C5WC 4LU9A 2Z06A 2IAEC 2HY1A 3THOB 3DSDA 5J28A 4NZVA 4JA7A 5JPFA 5F3WA 2WDEA 4IYPC 4B2OA 5DNYA 3QFMA 3IB7A 4I5NC 1Z2XA 2O8GA 3PSNA 1S3NA 2YEQA 3H68A 3RL5A 3K7WC 3EGGA 3ZU0A 2NYLC 2Q8UA 3E7AA 3V4YA 1QFCA 4V0WA 1S70A 3QFKA 4KBPA 3E7BA 1OI8A 1UF3A 1UTEA 1USHA 2KKNA 3H61A 1OIEA 4H2BA 2HYPA 3C9FA 1TCOA 2IE4C 2BCDA 4MOYA 4UT3A 4TUIA 4YKEA 3H62B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3P71 C;  1HPU A;  3JYF A;  4OR9 A;  2ZBM A;  1KBP A;  4FCX A;  4LTY A;  4Q7F A;  4UWQ A;  5C1V A;  2DFJ A;  2QFP A;  1II7 A;  3LL8 A;  1S8E A;  3HVQ A;  1S3L A;  4G9J A;  4FBK A;  2NXF A;  4F0Z A;  1XZW A;  1WAR A;  4H2F A;  3H66 A;  1MF8 A;  3AUZ A;  4IL1 A;  2Z72 A;  3H64 A;  4FBQ A;  4FBW A;  4O43 A;  1FJM A;  4ZX2 A;  3GVE A;  1M63 A;  3CK2 A;  1U32 A;  1QHW A;  3RQZ A;  4ZVZ A;  1NNW A;  3ICF A;  4UT2 A;  4H1S A;  1WAO 1;  2NPP C;  3QFO A;  4H2G A;  3EGH A;  1XM7 A;  4MP0 A;  4WWL A;  2QFR A;  3T1I A;  3RL3 A;  3PSO A;  3K7V C;  2BQ8 X;  1T71 A;  3FGA C;  4DT2 A;  2HYO A;  5INB A;  5GTU A;  1V73 A;  2R17 A;  4UT3 B;  4M0V A;  5HPE A;  3H60 A;  4J6O A;  2WDC A;  2YVT A;  2USH A;  4H2I A;  4ORA A;  5JJT A;  5JPE A;  2BDX A;  2QJC A;  4O24 A;  4O5G A;  1OID A;  4JA9 A;  2A22 A;  1G5B A;  5IOH A;  2WDF A;  2IE3 C;  4LAC C;  3H63 A;  4O4K A;  3H69 A;  4I5L C;  5EQV A;  2WDD A;  4MOV A;  3KBP A;  1Z2W A;  3ZTV A;  1SU1 A;  4XPN A;  3DW8 C;  4H1Y P;  3RL4 A;  1S3M A;  4KKZ A;  1IT6 A;  1HO5 A;  2Z1A A;  5B8I A;  4ORC A;  4HD0 A;  2JOG A;  2P6B A;  1AUI A;  3H67 A;  3IVE A;  4V0X A;  3TGH A;  3DSC A;  1JK7 A;  2XMO A;  2GJU A;  4ORB A;  2CV9 A;  1W24 A;  4DHL A;  3IVD A;  3QFN A;  4DSY A;  3AV0 A;  2O8A A;  3IB8 A;  2NYM C;  1T70 A;  4V0V A;  4TUG A;  3THN A;  1HP1 A;  1S95 A;  3QG5 C;  2AHD A;  3N5U A;  3C5W C;  4LU9 A;  2Z06 A;  2IAE C;  2HY1 A;  3THO B;  3DSD A;  5J28 A;  4NZV A;  4JA7 A;  5JPF A;  5F3W A;  2WDE A;  4IYP C;  4B2O A;  5DNY A;  3QFM A;  3IB7 A;  4I5N C;  1Z2X A;  2O8G A;  3PSN A;  1S3N A;  3RL5 A;  3H68 A;  3K7W C;  3EGG A;  3ZU0 A;  2NYL C;  2Q8U A;  3E7A A;  3V4Y A;  1QFC A;  4V0W A;  1S70 A;  3QFK A;  4KBP A;  3E7B A;  1OI8 A;  1UF3 A;  1UTE A;  1USH A;  2KKN A;  3H61 A;  1OIE A;  4H2B A;  2HYP A;  3C9F A;  1TCO A;  2IE4 C;  2BCD A;  4MOY A;  4UT3 A;  4TUI A;  4YKE A;  3H62 B; 
#chains in the Genus database with same CATH topology
 3P71 C;  1HPU A;  3JYF A;  4OR9 A;  2ZBM A;  1KBP A;  4FCX A;  4LTY A;  4Q7F A;  4UWQ A;  5C1V A;  2DFJ A;  2QFP A;  1II7 A;  3LL8 A;  1S8E A;  3HVQ A;  1S3L A;  4G9J A;  4FBK A;  2NXF A;  4F0Z A;  1XZW A;  1WAR A;  2DXL A;  4H2F A;  3H66 A;  1MF8 A;  3AUZ A;  4IL1 A;  2Z72 A;  3H64 A;  4FBQ A;  4FBW A;  4O43 A;  1FJM A;  4ZX2 A;  3GVE A;  1M63 A;  3CK2 A;  1U32 A;  1QHW A;  3RQZ A;  4ZVZ A;  1NNW A;  3ICF A;  4UT2 A;  4H1S A;  1WAO 1;  2NPP C;  3QFO A;  4H2G A;  3EGH A;  1XM7 A;  4MP0 A;  4WWL A;  2QFR A;  3D03 A;  3T1I A;  3RL3 A;  3PSO A;  3K7V C;  2BQ8 X;  1T71 A;  2ZOA A;  3FGA C;  4DT2 A;  2HYO A;  5INB A;  5GTU A;  1V73 A;  2R17 A;  4UT3 B;  4M0V A;  5HPE A;  3H60 A;  4J6O A;  2WDC A;  2YVT A;  2USH A;  4H2I A;  4ORA A;  5JJT A;  5JPE A;  2BDX A;  2QJC A;  4O24 A;  4O5G A;  1OID A;  4JA9 A;  2A22 A;  1G5B A;  5IOH A;  2WDF A;  2IE3 C;  4LAC C;  3H63 A;  4O4K A;  3H69 A;  4I5L C;  2ZO9 B;  5EQV A;  2DXN A;  2WDD A;  3KBP A;  4MOV A;  1Z2W A;  3ZTV A;  1SU1 A;  4XPN A;  3DW8 C;  4H1Y P;  3RL4 A;  1S3M A;  3E0J A;  4KKZ A;  1IT6 A;  1HO5 A;  2Z1A A;  5B8I A;  4ORC A;  4HD0 A;  2JOG A;  2P6B A;  1AUI A;  3H67 A;  3IVE A;  4V0X A;  3TGH A;  3DSC A;  1JK7 A;  2XMO A;  2GJU A;  4ORB A;  2CV9 A;  1W24 A;  4DHL A;  3IVD A;  3QFN A;  4DSY A;  3AV0 A;  2O8A A;  3IB8 A;  2NYM C;  1T70 A;  4V0V A;  3FLO A;  4TUG A;  3THN A;  1HP1 A;  1S95 A;  3QG5 C;  2AHD A;  3N5U A;  3C5W C;  4LU9 A;  2Z06 A;  2IAE C;  2HY1 A;  3THO B;  3DSD A;  5J28 A;  4NZV A;  4JA7 A;  5JPF A;  5F3W A;  2WDE A;  4IYP C;  4B2O A;  5DNY A;  3QFM A;  3IB7 A;  4I5N C;  1Z2X A;  2O8G A;  3PSN A;  1S3N A;  2YEQ A;  3H68 A;  3RL5 A;  3K7W C;  3EGG A;  3ZU0 A;  2NYL C;  2Q8U A;  3E7A A;  3V4Y A;  1QFC A;  4V0W A;  1S70 A;  3QFK A;  4KBP A;  3E7B A;  1OI8 A;  1UF3 A;  1UTE A;  1USH A;  2KKN A;  3H61 A;  1OIE A;  4H2B A;  2HYP A;  3C9F A;  1TCO A;  2IE4 C;  2BCD A;  4MOY A;  4UT3 A;  4TUI A;  4YKE A;  3H62 B; 
#chains in the Genus database with same CATH homology
 3P71 C;  1HPU A;  3JYF A;  4OR9 A;  2ZBM A;  1KBP A;  4FCX A;  4LTY A;  4Q7F A;  4UWQ A;  5C1V A;  2DFJ A;  2QFP A;  1II7 A;  3LL8 A;  1S8E A;  3HVQ A;  1S3L A;  4G9J A;  4FBK A;  2NXF A;  4F0Z A;  1XZW A;  1WAR A;  2DXL A;  4H2F A;  3H66 A;  1MF8 A;  3AUZ A;  4IL1 A;  2Z72 A;  3H64 A;  4FBQ A;  4FBW A;  4O43 A;  1FJM A;  4ZX2 A;  3GVE A;  1M63 A;  3CK2 A;  1U32 A;  1QHW A;  3RQZ A;  4ZVZ A;  1NNW A;  3ICF A;  4UT2 A;  4H1S A;  1WAO 1;  2NPP C;  3QFO A;  4H2G A;  3EGH A;  1XM7 A;  4MP0 A;  4WWL A;  2QFR A;  3D03 A;  3T1I A;  3RL3 A;  3PSO A;  3K7V C;  2BQ8 X;  1T71 A;  2ZOA A;  3FGA C;  4DT2 A;  2HYO A;  5INB A;  5GTU A;  1V73 A;  2R17 A;  4UT3 B;  4M0V A;  5HPE A;  3H60 A;  4J6O A;  2WDC A;  2YVT A;  2USH A;  4H2I A;  4ORA A;  5JJT A;  5JPE A;  2BDX A;  2QJC A;  4O24 A;  4O5G A;  1OID A;  4JA9 A;  2A22 A;  1G5B A;  5IOH A;  2WDF A;  2IE3 C;  4LAC C;  3H63 A;  4O4K A;  3H69 A;  4I5L C;  2ZO9 B;  5EQV A;  2DXN A;  2WDD A;  3KBP A;  4MOV A;  1Z2W A;  3ZTV A;  1SU1 A;  4XPN A;  3DW8 C;  4H1Y P;  3RL4 A;  1S3M A;  3E0J A;  4KKZ A;  1IT6 A;  1HO5 A;  2Z1A A;  5B8I A;  4ORC A;  4HD0 A;  2JOG A;  2P6B A;  1AUI A;  3H67 A;  3IVE A;  4V0X A;  3TGH A;  3DSC A;  1JK7 A;  2XMO A;  2GJU A;  4ORB A;  2CV9 A;  1W24 A;  4DHL A;  3IVD A;  3QFN A;  4DSY A;  3AV0 A;  2O8A A;  3IB8 A;  2NYM C;  1T70 A;  4V0V A;  3FLO A;  4TUG A;  3THN A;  1HP1 A;  1S95 A;  3QG5 C;  2AHD A;  3N5U A;  3C5W C;  4LU9 A;  2Z06 A;  2IAE C;  2HY1 A;  3THO B;  3DSD A;  5J28 A;  4NZV A;  4JA7 A;  5JPF A;  5F3W A;  2WDE A;  4IYP C;  4B2O A;  5DNY A;  3QFM A;  3IB7 A;  4I5N C;  1Z2X A;  2O8G A;  3PSN A;  1S3N A;  2YEQ A;  3H68 A;  3RL5 A;  3K7W C;  3EGG A;  3ZU0 A;  2NYL C;  2Q8U A;  3E7A A;  3V4Y A;  1QFC A;  4V0W A;  1S70 A;  3QFK A;  4KBP A;  3E7B A;  1OI8 A;  1UF3 A;  1UTE A;  1USH A;  2KKN A;  3H61 A;  1OIE A;  4H2B A;  2HYP A;  3C9F A;  1TCO A;  2IE4 C;  2BCD A;  4MOY A;  4UT3 A;  4TUI A;  4YKE A;  3H62 B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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