1TFSA

Nmr and restrained molecular dynamics study of the three-dimensional solution structure of toxin fs2, a specific blocker of the l-type calcium channel, isolated from black mamba venom
Total Genus 16
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
16
sequence length
60
structure length
60
Chain Sequence
RICYSHKASLPRATKTCVENTCYKMFIRTHREYISERGCGCPTAMWPYQTECCKGDRCNK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title NMR and restrained molecular dynamics study of the three-dimensional solution structure of toxin FS2, a specific blocker of the L-type calcium channel, isolated from black mamba venom.
pubmed doi rcsb
molecule keywords TOXIN FS2
molecule tags Toxin
source organism Dendroaspis polylepis polylepis
total genus 16
structure length 60
sequence length 60
ec nomenclature
pdb deposition date 1995-01-26
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.60.10 Mainly Beta Ribbon CD59 CD59 1tfsA00
2CTXA 1CDRA 1CB9A 2H62C 2GOOC 1ERAA 3BT1U 2GOOB 2H7ZA 1FRAA 1M9ZA 3NH7A 4FAOC 1TGXA 1IDIA 2CRTA 1KS6A 3VTSA 4LFTA 5DZ5A 3BT2U 3ERAA 4EY8B 1ZADA 1JE9A 2ERAA 1PLOA 2K3GA 2QJBC 1B41B 1HC9A 1I02A 1NXBA 5DO6A 1ONJA 1G6MA 2NBTA 1ES7B 2UX2A 1NEAA 1MAHF 2MUPA 3EVSC 6EBXA 4XJJA 4BIKB 1DRSA 1JGKA 1CHVS 1V6PA 1CCQA 2CCXA 1HAJA 2MFAA 2MJ0A 2N99A 1RGJA 1F8UB 1QM7A 3KFDE 4AEAA 3U74U 2HLRA 1FSSB 2MHYA 1MR6A 1CRFA 2QC1A 1IK8A 1FFJA 1CREA 1VB0A 1CVOA 2HLQA 2L03A 2UWRA 1CXNA 1H0JA 1IDLA 2LA1A 2QJAC 1S4YA 1UG4A 1FF4A 3QB4B 3HH7A 3U73U 3EBXA 1XT3A 4QTIU 1NTNA 1CTXA 2X8BB 2JVEA 1TFSA 2MJYA 1CDQA 1IKCA 1QKDA 1IDHA 1KTZB 1HAAA 2PJYC 1RL5A 2L5SA 2OFSA 2QJ9C 1QKEA 2CRSA 2J8BA 1F94A 2H5FA 2ABXA 1FASA 1TXBA 1IDGA 2H7ZB 1YWHA 5IMYC 4RUDA 4FAOE 1KBTA 1LXHA 1ERGA 3PLCA 4OM4A 4OM5A 2H62D 3FEVA 2VLWA 4HQPF 1KL8A 1KU6B 2JQPA 1W6BA 1FSCA 1BTEA 1LXGA 1HC9B 1KXIA 1CXOA 1HOYA 3LAQU 4UY2C 4ZQYA 1ABTA 1BXPA 3KFDI 5EBXA 1NORA 1KBSA 1KBAA 4P7UA 1TXAA 4DO8A 5IMTD 1IJCA 1IQ9A 2PJYB 1CDSA 2LCRA 1NYUA 3NDSA 2CDXA 5DU1A 2MUOA 1KC4A 4BDTB 2MJ4A 2BHIA 1CDTA 1KFHA 2H64C 2H64B 1LSIA 1NTXA 1COEA 1LJZA 1JBDA 1REWC 1L4WA 2BTXA 1LX5B 4IYEA 1NYSA 3NEQA 2I9BE 1CODA 2FD6U 2H8UA
chains in the Genus database with same CATH superfamily
2CTXA 1CDRA 1CB9A 2H62C 2GOOC 1ERAA 3BT1U 2GOOB 2H7ZA 1FRAA 1M9ZA 3NH7A 4FAOC 1TGXA 1IDIA 2CRTA 1KS6A 3VTSA 4LFTA 5DZ5A 3BT2U 3ERAA 4EY8B 1ZADA 1JE9A 2ERAA 1PLOA 2K3GA 2QJBC 1B41B 1HC9A 1I02A 1NXBA 5DO6A 1ONJA 1G6MA 2NBTA 1ES7B 2UX2A 1NEAA 1MAHF 2MUPA 3EVSC 6EBXA 4XJJA 4BIKB 1DRSA 1JGKA 1CHVS 1V6PA 1CCQA 2CCXA 1HAJA 2MFAA 2MJ0A 2N99A 1RGJA 1F8UB 1QM7A 3KFDE 4AEAA 3U74U 2HLRA 1FSSB 2MHYA 1MR6A 1CRFA 2QC1A 1IK8A 1FFJA 1CREA 1VB0A 1CVOA 2HLQA 2L03A 2UWRA 1CXNA 1H0JA 1IDLA 2LA1A 4KSNA 2QJAC 1S4YA 1UG4A 1FF4A 3QB4B 3HH7A 3U73U 3EBXA 1XT3A 4QTIU 1NTNA 1CTXA 2X8BB 2JVEA 1TFSA 2MJYA 1CDQA 1IKCA 1QKDA 1IDHA 1KTZB 1HAAA 2PJYC 1RL5A 2L5SA 2OFSA 2QJ9C 1QKEA 2CRSA 2J8BA 1F94A 2H5FA 2ABXA 1FASA 1TXBA 1IDGA 2H7ZB 1YWHA 5IMYC 4RUDA 4FAOE 1KBTA 1LXHA 1ERGA 3PLCA 4OM4A 4OM5A 2H62D 3FEVA 2VLWA 4HQPF 1KL8A 1KU6B 2JQPA 1W6BA 1FSCA 1BTEA 1LXGA 1HC9B 1KXIA 1CXOA 1HOYA 3LAQU 4UY2C 4ZQYA 1ABTA 1BXPA 3KFDI 5EBXA 1NORA 1KBSA 1KBAA 4P7UA 1TXAA 4DO8A 5IMTD 1IJCA 1IQ9A 2PJYB 1CDSA 2LCRA 1NYUA 3NDSA 2CDXA 5DU1A 2MUOA 1KC4A 4BDTB 2MJ4A 2BHIA 1CDTA 1KFHA 2H64C 2H64B 1LSIA 1NTXA 1COEA 1LJZA 1JBDA 1REWC 1L4WA 2BTXA 1LX5B 4IYEA 1NYSA 3NEQA 2I9BE 1CODA 2FD6U 2H8UA
chains in the Genus database with same CATH topology
2CTXA 1CDRA 1CB9A 2H62C 2GOOC 1ERAA 3BT1U 2GOOB 2H7ZA 1FRAA 1M9ZA 3NH7A 4FAOC 1TGXA 1IDIA 2CRTA 1KS6A 3VTSA 4LFTA 5DZ5A 3BT2U 3ERAA 4EY8B 1ZADA 1JE9A 2ERAA 1PLOA 2K3GA 2QJBC 1B41B 1HC9A 1I02A 1NXBA 5DO6A 1ONJA 1G6MA 2NBTA 1ES7B 2UX2A 1NEAA 1MAHF 2MUPA 3EVSC 6EBXA 4XJJA 4BIKB 1DRSA 1JGKA 1CHVS 1V6PA 1CCQA 2CCXA 1HAJA 2MFAA 2MJ0A 2N99A 1RGJA 1F8UB 1QM7A 3KFDE 4AEAA 3U74U 2HLRA 1FSSB 2MHYA 1MR6A 1CRFA 2QC1A 1IK8A 1FFJA 1CREA 1VB0A 1CVOA 2HLQA 2L03A 2UWRA 1CXNA 1H0JA 1IDLA 2LA1A 4KSNA 2QJAC 1S4YA 1UG4A 1FF4A 3QB4B 3HH7A 3U73U 3EBXA 1XT3A 4QTIU 1NTNA 1CTXA 2X8BB 2JVEA 1TFSA 2MJYA 1CDQA 1IKCA 1QKDA 1IDHA 1KTZB 1HAAA 2PJYC 1RL5A 2L5SA 2OFSA 2QJ9C 1QKEA 2CRSA 2J8BA 1F94A 2H5FA 2ABXA 1FASA 1TXBA 1IDGA 2H7ZB 1YWHA 5IMYC 4RUDA 4FAOE 1KBTA 1LXHA 1ERGA 3PLCA 4OM4A 4OM5A 2H62D 3FEVA 2VLWA 4HQPF 1KL8A 1KU6B 2JQPA 1W6BA 1FSCA 1BTEA 1LXGA 1HC9B 1KXIA 1CXOA 1HOYA 3LAQU 4UY2C 4ZQYA 1ABTA 1BXPA 3KFDI 5EBXA 1NORA 1KBSA 1KBAA 4P7UA 1TXAA 4DO8A 5IMTD 1IJCA 1IQ9A 2PJYB 1CDSA 2LCRA 1NYUA 3NDSA 2CDXA 5DU1A 2MUOA 1KC4A 4BDTB 2MJ4A 2BHIA 1CDTA 1KFHA 2H64C 2H64B 1LSIA 1NTXA 1COEA 1LJZA 1JBDA 1REWC 1L4WA 2BTXA 1LX5B 4IYEA 1NYSA 3NEQA 2I9BE 1CODA 2FD6U 2H8UA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2CTX A;  1CDR A;  1CB9 A;  2H62 C;  2GOO C;  1ERA A;  3BT1 U;  2GOO B;  2H7Z A;  1FRA A;  1M9Z A;  3NH7 A;  4FAO C;  1TGX A;  1IDI A;  2CRT A;  1KS6 A;  3VTS A;  4LFT A;  5DZ5 A;  3BT2 U;  3ERA A;  4EY8 B;  1ZAD A;  1JE9 A;  2ERA A;  1PLO A;  2K3G A;  2QJB C;  1B41 B;  1HC9 A;  1I02 A;  1NXB A;  5DO6 A;  1ONJ A;  1G6M A;  2NBT A;  1ES7 B;  2UX2 A;  1NEA A;  1MAH F;  2MUP A;  3EVS C;  6EBX A;  4XJJ A;  4BIK B;  1DRS A;  1JGK A;  1CHV S;  1V6P A;  1CCQ A;  2CCX A;  1HAJ A;  2MFA A;  2MJ0 A;  2N99 A;  1RGJ A;  1F8U B;  1QM7 A;  3KFD E;  4AEA A;  3U74 U;  2HLR A;  1FSS B;  2MHY A;  1MR6 A;  1CRF A;  2QC1 A;  1IK8 A;  1FFJ A;  1CRE A;  1VB0 A;  1CVO A;  2HLQ A;  2L03 A;  2UWR A;  1CXN A;  1H0J A;  1IDL A;  2LA1 A;  2QJA C;  1S4Y A;  1UG4 A;  1FF4 A;  3QB4 B;  3HH7 A;  3U73 U;  3EBX A;  1XT3 A;  4QTI U;  1NTN A;  1CTX A;  2X8B B;  2JVE A;  1TFS A;  2MJY A;  1CDQ A;  1IKC A;  1QKD A;  1IDH A;  1KTZ B;  1HAA A;  2PJY C;  1RL5 A;  2L5S A;  2OFS A;  2QJ9 C;  1QKE A;  2CRS A;  2J8B A;  1F94 A;  2H5F A;  2ABX A;  1FAS A;  1TXB A;  1IDG A;  2H7Z B;  1YWH A;  5IMY C;  4RUD A;  4FAO E;  1KBT A;  1LXH A;  1ERG A;  3PLC A;  4OM4 A;  4OM5 A;  2H62 D;  3FEV A;  2VLW A;  4HQP F;  1KL8 A;  1KU6 B;  2JQP A;  1W6B A;  1FSC A;  1BTE A;  1LXG A;  1HC9 B;  1KXI A;  1CXO A;  1HOY A;  3LAQ U;  4UY2 C;  4ZQY A;  1ABT A;  1BXP A;  3KFD I;  5EBX A;  1NOR A;  1KBS A;  1KBA A;  4P7U A;  1TXA A;  4DO8 A;  5IMT D;  1IJC A;  1IQ9 A;  2PJY B;  1CDS A;  2LCR A;  1NYU A;  3NDS A;  2CDX A;  5DU1 A;  2MUO A;  1KC4 A;  4BDT B;  2MJ4 A;  2BHI A;  1CDT A;  1KFH A;  2H64 C;  2H64 B;  1LSI A;  1NTX A;  1COE A;  1LJZ A;  1JBD A;  1REW C;  1L4W A;  2BTX A;  1LX5 B;  4IYE A;  1NYS A;  3NEQ A;  2I9B E;  1COD A;  2FD6 U;  2H8U A; 
#chains in the Genus database with same CATH topology
 2CTX A;  1CDR A;  1CB9 A;  2H62 C;  2GOO C;  1ERA A;  3BT1 U;  2GOO B;  2H7Z A;  1FRA A;  1M9Z A;  3NH7 A;  4FAO C;  1TGX A;  1IDI A;  2CRT A;  1KS6 A;  3VTS A;  4LFT A;  5DZ5 A;  3BT2 U;  3ERA A;  4EY8 B;  1ZAD A;  1JE9 A;  2ERA A;  1PLO A;  2K3G A;  2QJB C;  1B41 B;  1HC9 A;  1I02 A;  1NXB A;  5DO6 A;  1ONJ A;  1G6M A;  2NBT A;  1ES7 B;  2UX2 A;  1NEA A;  1MAH F;  2MUP A;  3EVS C;  6EBX A;  4XJJ A;  4BIK B;  1DRS A;  1JGK A;  1CHV S;  1V6P A;  1CCQ A;  2CCX A;  1HAJ A;  2MFA A;  2MJ0 A;  2N99 A;  1RGJ A;  1F8U B;  1QM7 A;  3KFD E;  4AEA A;  3U74 U;  2HLR A;  1FSS B;  2MHY A;  1MR6 A;  1CRF A;  2QC1 A;  1IK8 A;  1FFJ A;  1CRE A;  1VB0 A;  1CVO A;  2HLQ A;  2L03 A;  2UWR A;  1CXN A;  1H0J A;  1IDL A;  2LA1 A;  4KSN A;  2QJA C;  1S4Y A;  1UG4 A;  1FF4 A;  3QB4 B;  3HH7 A;  3U73 U;  3EBX A;  1XT3 A;  4QTI U;  1NTN A;  1CTX A;  2X8B B;  2JVE A;  1TFS A;  2MJY A;  1CDQ A;  1IKC A;  1QKD A;  1IDH A;  1KTZ B;  1HAA A;  2PJY C;  1RL5 A;  2L5S A;  2OFS A;  2QJ9 C;  1QKE A;  2CRS A;  2J8B A;  1F94 A;  2H5F A;  2ABX A;  1FAS A;  1TXB A;  1IDG A;  2H7Z B;  1YWH A;  5IMY C;  4RUD A;  4FAO E;  1KBT A;  1LXH A;  1ERG A;  3PLC A;  4OM4 A;  4OM5 A;  2H62 D;  3FEV A;  2VLW A;  4HQP F;  1KL8 A;  1KU6 B;  2JQP A;  1W6B A;  1FSC A;  1BTE A;  1LXG A;  1HC9 B;  1KXI A;  1CXO A;  1HOY A;  3LAQ U;  4UY2 C;  4ZQY A;  1ABT A;  1BXP A;  3KFD I;  5EBX A;  1NOR A;  1KBS A;  1KBA A;  4P7U A;  1TXA A;  4DO8 A;  5IMT D;  1IJC A;  1IQ9 A;  2PJY B;  1CDS A;  2LCR A;  1NYU A;  3NDS A;  2CDX A;  5DU1 A;  2MUO A;  1KC4 A;  4BDT B;  2MJ4 A;  2BHI A;  1CDT A;  1KFH A;  2H64 C;  2H64 B;  1LSI A;  1NTX A;  1COE A;  1LJZ A;  1JBD A;  1REW C;  1L4W A;  2BTX A;  1LX5 B;  4IYE A;  1NYS A;  3NEQ A;  2I9B E;  1COD A;  2FD6 U;  2H8U A; 
#chains in the Genus database with same CATH homology
 2CTX A;  1CDR A;  1CB9 A;  2H62 C;  2GOO C;  1ERA A;  3BT1 U;  2GOO B;  2H7Z A;  1FRA A;  1M9Z A;  3NH7 A;  4FAO C;  1TGX A;  1IDI A;  2CRT A;  1KS6 A;  3VTS A;  4LFT A;  5DZ5 A;  3BT2 U;  3ERA A;  4EY8 B;  1ZAD A;  1JE9 A;  2ERA A;  1PLO A;  2K3G A;  2QJB C;  1B41 B;  1HC9 A;  1I02 A;  1NXB A;  5DO6 A;  1ONJ A;  1G6M A;  2NBT A;  1ES7 B;  2UX2 A;  1NEA A;  1MAH F;  2MUP A;  3EVS C;  6EBX A;  4XJJ A;  4BIK B;  1DRS A;  1JGK A;  1CHV S;  1V6P A;  1CCQ A;  2CCX A;  1HAJ A;  2MFA A;  2MJ0 A;  2N99 A;  1RGJ A;  1F8U B;  1QM7 A;  3KFD E;  4AEA A;  3U74 U;  2HLR A;  1FSS B;  2MHY A;  1MR6 A;  1CRF A;  2QC1 A;  1IK8 A;  1FFJ A;  1CRE A;  1VB0 A;  1CVO A;  2HLQ A;  2L03 A;  2UWR A;  1CXN A;  1H0J A;  1IDL A;  2LA1 A;  4KSN A;  2QJA C;  1S4Y A;  1UG4 A;  1FF4 A;  3QB4 B;  3HH7 A;  3U73 U;  3EBX A;  1XT3 A;  4QTI U;  1NTN A;  1CTX A;  2X8B B;  2JVE A;  1TFS A;  2MJY A;  1CDQ A;  1IKC A;  1QKD A;  1IDH A;  1KTZ B;  1HAA A;  2PJY C;  1RL5 A;  2L5S A;  2OFS A;  2QJ9 C;  1QKE A;  2CRS A;  2J8B A;  1F94 A;  2H5F A;  2ABX A;  1FAS A;  1TXB A;  1IDG A;  2H7Z B;  1YWH A;  5IMY C;  4RUD A;  4FAO E;  1KBT A;  1LXH A;  1ERG A;  3PLC A;  4OM4 A;  4OM5 A;  2H62 D;  3FEV A;  2VLW A;  4HQP F;  1KL8 A;  1KU6 B;  2JQP A;  1W6B A;  1FSC A;  1BTE A;  1LXG A;  1HC9 B;  1KXI A;  1CXO A;  1HOY A;  3LAQ U;  4UY2 C;  4ZQY A;  1ABT A;  1BXP A;  3KFD I;  5EBX A;  1NOR A;  1KBS A;  1KBA A;  4P7U A;  1TXA A;  4DO8 A;  5IMT D;  1IJC A;  1IQ9 A;  2PJY B;  1CDS A;  2LCR A;  1NYU A;  3NDS A;  2CDX A;  5DU1 A;  2MUO A;  1KC4 A;  4BDT B;  2MJ4 A;  2BHI A;  1CDT A;  1KFH A;  2H64 C;  2H64 B;  1LSI A;  1NTX A;  1COE A;  1LJZ A;  1JBD A;  1REW C;  1L4W A;  2BTX A;  1LX5 B;  4IYE A;  1NYS A;  3NEQ A;  2I9B E;  1COD A;  2FD6 U;  2H8U A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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