1TGRA

Crystal structure of mini-igf-1(2)
Total Genus 16
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
16
sequence length
52
structure length
52
Chain Sequence
GPETLCGAELVDALQFVCGDRGFYFNKPKAKGIVDECCFRSCDLRRLEMYCA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hormone/growth factor
molecule keywords Insulin-like growth factor IA
publication title 1.42A crystal structure of mini-IGF-1(2): an analysis of the disulfide isomerization property and receptor binding property of IGF-1 based on the three-dimensional structure
pubmed doi rcsb
source organism Homo sapiens
total genus 16
structure length 52
sequence length 52
chains with identical sequence B
ec nomenclature
pdb deposition date 2004-05-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00049 Insulin Insulin/IGF/Relaxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.100.10 Mainly Alpha Orthogonal Bundle Insulin-like, subunit E Insulin-like 1tgrA00
1GZYB 1GZRB 2DSRI 1H02B 1IGLA 3LRIA 4XSSB 2GF1A 2LWZA 3GF1A 1PMXA 1ZEIA 2KJIA 5L3LA 5L3NA 1IMXA 5L3MA 1GZZB 2L29B 2DSPI 2KQPA 3KR3D 1TGRA 1BQTA 2JZQA 1EFEA 1H59A 6INSE 1WQJI 1B9GA 1SJUA 2DSQC
chains in the Genus database with same CATH superfamily
1GZYB 1GZRB 2DSRI 1H02B 1IGLA 3LRIA 4XSSB 2GF1A 2LWZA 3GF1A 1PMXA 1ZEIA 2KJIA 5L3LA 5L3NA 1IMXA 2L14B 5L3MA 1GZZB 3F2BA 2L29B 3F2CA 2DSPI 2KQPA 3KR3D 1TGRA 1BQTA 2JZQA 1EFEA 1H59A 6INSE 3F2DA 1WQJI 1B9GA 1SJUA 2DSQC
chains in the Genus database with same CATH topology
1GZYB 1GZRB 2DSRI 1H02B 1IGLA 3LRIA 4XSSB 2GF1A 2LWZA 3GF1A 1PMXA 1ZEIA 2KJIA 5L3LA 5L3NA 1IMXA 5L3MA 1GZZB 2L29B 2DSPI 2KQPA 3KR3D 1TGRA 1BQTA 2JZQA 1EFEA 1H59A 6INSE 1WQJI 1B9GA 1SJUA 2DSQC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1GZY B;  1GZR B;  2DSR I;  1H02 B;  1IGL A;  3LRI A;  4XSS B;  2GF1 A;  2LWZ A;  3GF1 A;  1PMX A;  1ZEI A;  2KJI A;  5L3L A;  5L3N A;  1IMX A;  5L3M A;  1GZZ B;  2L29 B;  2DSP I;  2KQP A;  3KR3 D;  1TGR A;  1BQT A;  2JZQ A;  1EFE A;  1H59 A;  6INS E;  1WQJ I;  1B9G A;  1SJU A;  2DSQ C; 
#chains in the Genus database with same CATH topology
 1GZY B;  1GZR B;  2DSR I;  1H02 B;  1IGL A;  3LRI A;  4XSS B;  2GF1 A;  2LWZ A;  3GF1 A;  1PMX A;  1ZEI A;  2KJI A;  5L3L A;  5L3N A;  1IMX A;  2L14 B;  5L3M A;  1GZZ B;  3F2B A;  2L29 B;  3F2C A;  2DSP I;  2KQP A;  3KR3 D;  1TGR A;  1BQT A;  2JZQ A;  1EFE A;  1H59 A;  6INS E;  3F2D A;  1WQJ I;  1B9G A;  1SJU A;  2DSQ C; 
#chains in the Genus database with same CATH homology
 1GZY B;  1GZR B;  2DSR I;  1H02 B;  1IGL A;  3LRI A;  4XSS B;  2GF1 A;  2LWZ A;  3GF1 A;  1PMX A;  1ZEI A;  2KJI A;  5L3L A;  5L3N A;  1IMX A;  5L3M A;  1GZZ B;  2L29 B;  2DSP I;  2KQP A;  3KR3 D;  1TGR A;  1BQT A;  2JZQ A;  1EFE A;  1H59 A;  6INS E;  1WQJ I;  1B9G A;  1SJU A;  2DSQ C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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