1TJTA

X-ray structure of the human alpha-actinin isoform 3 at 2.2a resolution
Total Genus 82
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
82
sequence length
224
structure length
224
Chain Sequence
AWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The crystal structure of the actin binding domain from alpha-actinin in its closed conformation: structural insight into phospholipid regulation of alpha-actinin
pubmed doi rcsb
molecule tags Contractile protein
source organism Homo sapiens
molecule keywords Alpha-actinin 3
total genus 82
structure length 224
sequence length 224
ec nomenclature
pdb deposition date 2004-06-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00307 CH Calponin homology (CH) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 1tjtA02
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 1tjtA01
5A4BA 1WKUA 1V5KA 1H67A 1WYNA 3F7PA 5A36A 5A38A 4TXKA 1BKRA 1WJOA 1RT8A 1QAGA 1P5SA 2VZDA 1PXYA 1SH6A 4TXIA 4EDNA 2WFNA 2QJXA 5A37A 1WYRA 3FERA 2D86A 2D88A 3CO1A 2WA6A 2VZGB 4B7LA 1VKAA 1WYOA 5L0OA 3HOPA 1AA2A 5J8EA 1TJTA 1UJOA 2RR8A 3HOCA 1SH5A 4Q58A 2EYIA 4Q57B 2YRNA 3KY9A 3I6XA 2JV9A 2WA5A 4Q59A 1AOAA 1WIXA 2K2RA 2DK9A 1DXXA 3JARM 2D87A 1P2XA 5BVRA 3REPB 2R8UA 4EDMA 3JALM 1UEGA 1WYPA 2R0OA 3KMWB 1WYLA 2K3SA 2QJZA 1PA7A 2EE7A 2WA7A 2D85A 2D89A 1MB8A 2VZCA 3KMUB 1BHDA 2E9KA 1WYQA 4EDLA 2VZIB 2L3GA 3HORA 3JAKM 2EYNA 1WYMA
chains in the Genus database with same CATH superfamily
5A4BA 1WKUA 2HL9A 1V5KA 1H67A 1WYNA 3F7PA 5A36A 5A38A 2HKPA 4LVRA 4TXKA 1BKRA 1WJOA 1RT8A 1QAGA 1P5SA 2VZDA 2WE6A 3EAYA 1PXYA 1SH6A 4TXIA 4EDNA 2WFNA 2QJXA 5A37A 1WYRA 3FERA 2D86A 2D88A 3CO1A 2WA6A 2VZGB 4B7LA 1VKAA 1WYOA 5L0OA 2VE7A 3HOPA 4LVPA 2EQOA 1AA2A 5J8EA 1TJTA 1UJOA 2RR8A 3HOCA 5FMUA 1SH5A 4Q58A 2EYIA 4Q57B 2YRNA 4DDPA 3KY9A 3I6XA 2JV9A 2WA5A 4Q59A 1AOAA 2HL8A 1WIXA 2IGPA 1EUVA 2K2RA 2DK9A 1DXXA 3JARM 2WDTA 2D87A 1P2XA 5BVRA 3REPB 2R8UA 4EDMA 3JALM 1UEGA 1WYPA 2VE7C 2R0OA 3KMWB 1WYLA 2K3SA 2QJZA 1PA7A 2EE7A 2WA7A 2D85A 2D89A 1MB8A 5FMTA 2VZCA 3KMUB 1BHDA 2E9KA 1WYQA 4EDLA 2VZIB 2L3GA 3HORA 3JAKM 2EYNA 3VP7A 1WYMA
chains in the Genus database with same CATH topology
5A4BA 1WKUA 1V5KA 1H67A 1WYNA 3F7PA 5A36A 5A38A 4TXKA 1BKRA 1WJOA 1RT8A 1QAGA 1P5SA 2VZDA 1PXYA 1SH6A 4TXIA 4EDNA 2WFNA 2QJXA 5A37A 1WYRA 3FERA 2D86A 2D88A 3CO1A 2WA6A 2VZGB 4B7LA 1VKAA 1WYOA 5L0OA 3HOPA 1AA2A 5J8EA 1TJTA 1UJOA 2RR8A 3HOCA 1SH5A 4Q58A 2EYIA 4Q57B 2YRNA 3KY9A 3I6XA 2JV9A 2WA5A 4Q59A 1AOAA 1WIXA 2K2RA 2DK9A 1DXXA 3JARM 2D87A 1P2XA 5BVRA 3REPB 2R8UA 4EDMA 3JALM 1UEGA 1WYPA 2R0OA 3KMWB 1WYLA 2K3SA 2QJZA 1PA7A 2EE7A 2WA7A 2D85A 2D89A 1MB8A 2VZCA 3KMUB 1BHDA 2E9KA 1WYQA 4EDLA 2VZIB 2L3GA 3HORA 3JAKM 2EYNA 1WYMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5A4B A;  1WKU A;  1V5K A;  1H67 A;  1WYN A;  3F7P A;  5A36 A;  5A38 A;  4TXK A;  1BKR A;  1WJO A;  1RT8 A;  1QAG A;  1P5S A;  2VZD A;  1PXY A;  1SH6 A;  4TXI A;  4EDN A;  2WFN A;  2QJX A;  5A37 A;  1WYR A;  3FER A;  2D86 A;  2D88 A;  3CO1 A;  2WA6 A;  2VZG B;  4B7L A;  1VKA A;  1WYO A;  5L0O A;  3HOP A;  1AA2 A;  5J8E A;  1TJT A;  1UJO A;  2RR8 A;  3HOC A;  1SH5 A;  4Q58 A;  2EYI A;  4Q57 B;  2YRN A;  3KY9 A;  3I6X A;  2JV9 A;  2WA5 A;  4Q59 A;  1AOA A;  1WIX A;  2K2R A;  2DK9 A;  1DXX A;  3JAR M;  2D87 A;  1P2X A;  5BVR A;  3REP B;  2R8U A;  4EDM A;  3JAL M;  1UEG A;  1WYP A;  2R0O A;  3KMW B;  1WYL A;  2K3S A;  2QJZ A;  1PA7 A;  2EE7 A;  2WA7 A;  2D85 A;  2D89 A;  1MB8 A;  2VZC A;  3KMU B;  1BHD A;  2E9K A;  1WYQ A;  4EDL A;  2VZI B;  2L3G A;  3HOR A;  3JAK M;  2EYN A;  1WYM A; 
#chains in the Genus database with same CATH topology
 5A4B A;  1WKU A;  2HL9 A;  1V5K A;  1H67 A;  1WYN A;  3F7P A;  5A36 A;  5A38 A;  2HKP A;  4LVR A;  4TXK A;  1BKR A;  1WJO A;  1RT8 A;  1QAG A;  1P5S A;  2VZD A;  2WE6 A;  3EAY A;  1PXY A;  1SH6 A;  4TXI A;  4EDN A;  2WFN A;  2QJX A;  5A37 A;  1WYR A;  3FER A;  2D86 A;  2D88 A;  3CO1 A;  2WA6 A;  2VZG B;  4B7L A;  1VKA A;  1WYO A;  5L0O A;  2VE7 A;  3HOP A;  4LVP A;  2EQO A;  1AA2 A;  5J8E A;  1TJT A;  1UJO A;  2RR8 A;  3HOC A;  5FMU A;  1SH5 A;  4Q58 A;  2EYI A;  4Q57 B;  2YRN A;  4DDP A;  3KY9 A;  3I6X A;  2JV9 A;  2WA5 A;  4Q59 A;  1AOA A;  2HL8 A;  1WIX A;  2IGP A;  1EUV A;  2K2R A;  2DK9 A;  1DXX A;  3JAR M;  2WDT A;  2D87 A;  1P2X A;  5BVR A;  3REP B;  2R8U A;  4EDM A;  3JAL M;  1UEG A;  1WYP A;  2VE7 C;  2R0O A;  3KMW B;  1WYL A;  2K3S A;  2QJZ A;  1PA7 A;  2EE7 A;  2WA7 A;  2D85 A;  2D89 A;  1MB8 A;  5FMT A;  2VZC A;  3KMU B;  1BHD A;  2E9K A;  1WYQ A;  4EDL A;  2VZI B;  2L3G A;  3HOR A;  3JAK M;  2EYN A;  3VP7 A;  1WYM A; 
#chains in the Genus database with same CATH homology
 5A4B A;  1WKU A;  1V5K A;  1H67 A;  1WYN A;  3F7P A;  5A36 A;  5A38 A;  4TXK A;  1BKR A;  1WJO A;  1RT8 A;  1QAG A;  1P5S A;  2VZD A;  1PXY A;  1SH6 A;  4TXI A;  4EDN A;  2WFN A;  2QJX A;  5A37 A;  1WYR A;  3FER A;  2D86 A;  2D88 A;  3CO1 A;  2WA6 A;  2VZG B;  4B7L A;  1VKA A;  1WYO A;  5L0O A;  3HOP A;  1AA2 A;  5J8E A;  1TJT A;  1UJO A;  2RR8 A;  3HOC A;  1SH5 A;  4Q58 A;  2EYI A;  4Q57 B;  2YRN A;  3KY9 A;  3I6X A;  2JV9 A;  2WA5 A;  4Q59 A;  1AOA A;  1WIX A;  2K2R A;  2DK9 A;  1DXX A;  3JAR M;  2D87 A;  1P2X A;  5BVR A;  3REP B;  2R8U A;  4EDM A;  3JAL M;  1UEG A;  1WYP A;  2R0O A;  3KMW B;  1WYL A;  2K3S A;  2QJZ A;  1PA7 A;  2EE7 A;  2WA7 A;  2D85 A;  2D89 A;  1MB8 A;  2VZC A;  3KMU B;  1BHD A;  2E9K A;  1WYQ A;  4EDL A;  2VZI B;  2L3G A;  3HOR A;  3JAK M;  2EYN A;  1WYM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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