1TPAI

The geometry of the reactive site and of the peptide groups in trypsin, trypsinogen and its complexes with inhibitors
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
58
structure length
58
Chain Sequence
RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Complex (proteinase/inhibitor)
molecule keywords ANHYDRO-TRYPSIN
publication title The Geometry of the Reactive Site and of the Peptide Groups in Trypsin, Trypsinogen and its Complexes with Inhibitors
pubmed rcsb
source organism Bos taurus
total genus 11
structure length 58
sequence length 58
ec nomenclature
pdb deposition date 1982-09-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 1tpaI00
1BPTA 2IJOI 3BYBA 3AUBA 3BTEI 3OTJI 3TGJI 1TAPA 2CA7A 1BTHP 3FP7J 1P2KI 1KTHA 1KNTA 1P2NB 4Y0YI 1DTXA 3M7QB 1BRBI 2RA3C 3BTGI 2ZVXA 3BTKI 1UUAA 3D65I 4Y0ZI 1Y62A 3AUHA 4U32X 1P2JI 1DENA 3FP8I 1P2OB 1YKTB 2LFKA 3U1JE 3FP6I 3BTQI 1BTIA 5JB6A 1TOCR 1CBWD 1K6UA 1FAKI 1G6XA 4Y11I 1PITA 2M99A 3AUEA 1EJMB 3UIRC 5C67C 1T8MB 1LD6A 3L33E 2FTLI 1JC6A 4DG4C 1BUNB 2ZJXA 2J6DA 2FI4I 2FI3I 5JB7A 4DTGK 1KIGI 3TGII 1BIKA 1ZJDB 1BZXI 1BRCI 1TCPA 3BTTI 3WNYA 2UUYB 3L3TE 1P2MB 2FI5I 4BQDA 2LFLA 1BZ5A 1YLCB 1P2QB 1IRHA 2FTMB 3AUGA 3BTWI 1BPIA 3TPII 1F7ZI 1FANA 4NTXB 1OA55 3LDJA 3UOUB 3AUIA 1YLDB 2ODYE 3BTMI 1T8LB 7PTIA 3T62D 2R9PE 1TFXC 3GYMI 1SHPA 2KNTA 2TPII 3P92E 4U30W 3AUCA 4ISOB 4PTIA 1F5RI 1AAPA 1CA0D 3LDMA 1T8OB 1TAWB 2DDIA 3BTDI 2JOTA 6PTIA 2HEXA 1FY8I 1UUBA 9PTIA 1ZR0B 1BF0A 5JB5A 8PTIA 1T7CB 4BNRI 2KCRA 4ISLB 3TGKI 1KUNA 2W8XA 2TGPI 3AUDA 5JB4A 3BTFI 1B0CA 4WWYC 1TPAI 3P95E 1LD5A 4NTWB 4ISNB 5PTIA 1MTND 1YC0I 1QLQA 2UUXA 3LDIA 1JV8A 1ADZA 4BD9B 3CI7A 1CO7I 1NAGA 1D0DA 2DDJA 1BHCA 1DTKA 1DEMA 4NTYB 1D0DB 4WXVC 2M01A 1P2II 4Y10I 3OFWA 2KAII 1OA65 1AALA 4TPII 3BTHI 2PTCI 1JV9A 1EAWB 1T8NB
chains in the Genus database with same CATH superfamily
1BPTA 2IJOI 3BYBA 3AUBA 3BTEI 3OTJI 3TGJI 1TAPA 2CA7A 1BTHP 3FP7J 1P2KI 1KTHA 1KNTA 1P2NB 4Y0YI 1DTXA 3M7QB 1BRBI 2RA3C 3BTGI 2ZVXA 3BTKI 1UUAA 3D65I 4Y0ZI 1Y62A 3AUHA 4U32X 1P2JI 1DENA 3FP8I 1P2OB 1YKTB 2LFKA 3U1JE 3FP6I 3BTQI 1BTIA 5JB6A 1TOCR 1CBWD 1K6UA 1FAKI 1G6XA 4Y11I 1PITA 2M99A 3AUEA 1EJMB 3UIRC 5C67C 1T8MB 1LD6A 3L33E 2FTLI 1JC6A 4DG4C 1BUNB 2ZJXA 2J6DA 2FI4I 2FI3I 5JB7A 4DTGK 1KIGI 3TGII 1BIKA 1ZJDB 1BZXI 1BRCI 1TCPA 3BTTI 3WNYA 2UUYB 3L3TE 1P2MB 2FI5I 4BQDA 2LFLA 1BZ5A 1YLCB 1P2QB 1IRHA 2FTMB 3AUGA 3BTWI 1BPIA 3TPII 1F7ZI 1FANA 4NTXB 1OA55 3LDJA 3UOUB 3AUIA 1YLDB 2ODYE 3BTMI 1T8LB 7PTIA 3T62D 2R9PE 1TFXC 3GYMI 1SHPA 2KNTA 2TPII 3P92E 4U30W 3AUCA 4ISOB 4PTIA 1F5RI 1AAPA 1CA0D 3LDMA 1T8OB 1TAWB 2DDIA 3BTDI 2JOTA 6PTIA 2HEXA 1FY8I 1UUBA 9PTIA 1ZR0B 1BF0A 5JB5A 8PTIA 1T7CB 4BNRI 2KCRA 4ISLB 3TGKI 1KUNA 2W8XA 2TGPI 3AUDA 5JB4A 3BTFI 1B0CA 4WWYC 1TPAI 3P95E 1LD5A 4NTWB 4ISNB 5PTIA 1MTND 1YC0I 1QLQA 2UUXA 3LDIA 1JV8A 1ADZA 4BD9B 3CI7A 1CO7I 1NAGA 1D0DA 2DDJA 1BHCA 1DTKA 1DEMA 4NTYB 1D0DB 4WXVC 2M01A 1P2II 4Y10I 3OFWA 2KAII 1OA65 1AALA 4TPII 3BTHI 2PTCI 1JV9A 1EAWB 1T8NB
chains in the Genus database with same CATH topology
1BPTA 2IJOI 3BYBA 3AUBA 3BTEI 3OTJI 3TGJI 1TAPA 2CA7A 1BTHP 3FP7J 1P2KI 1KTHA 1KNTA 1P2NB 4Y0YI 1DTXA 3M7QB 1BRBI 2RA3C 3BTGI 2ZVXA 3BTKI 1UUAA 3D65I 4Y0ZI 1Y62A 3AUHA 4U32X 1P2JI 1DENA 3FP8I 1P2OB 1YKTB 2LFKA 3U1JE 3FP6I 3BTQI 1BTIA 5JB6A 1TOCR 1CBWD 1K6UA 1FAKI 1G6XA 4Y11I 1PITA 2M99A 3AUEA 1EJMB 3UIRC 5C67C 1T8MB 1LD6A 3L33E 2FTLI 1JC6A 4DG4C 1BUNB 2ZJXA 2J6DA 2FI4I 2FI3I 5JB7A 4DTGK 1KIGI 3TGII 1BIKA 1ZJDB 1BZXI 1BRCI 1TCPA 3BTTI 3WNYA 2UUYB 3L3TE 1P2MB 2FI5I 4BQDA 2LFLA 1BZ5A 1YLCB 1P2QB 1IRHA 2FTMB 3AUGA 3BTWI 1BPIA 3TPII 1F7ZI 1FANA 4NTXB 1OA55 3LDJA 3UOUB 3AUIA 1YLDB 2ODYE 3BTMI 1T8LB 7PTIA 3T62D 2R9PE 1TFXC 3GYMI 1SHPA 2KNTA 2TPII 3P92E 4U30W 3AUCA 4ISOB 4PTIA 1F5RI 1AAPA 1CA0D 3LDMA 1T8OB 1TAWB 2DDIA 3BTDI 2JOTA 6PTIA 2HEXA 1FY8I 1UUBA 9PTIA 1ZR0B 1BF0A 5JB5A 8PTIA 1T7CB 4BNRI 2KCRA 4ISLB 3TGKI 1KUNA 2W8XA 2TGPI 3AUDA 5JB4A 3BTFI 1B0CA 4WWYC 1TPAI 3P95E 1LD5A 4NTWB 4ISNB 5PTIA 1MTND 1YC0I 1QLQA 2UUXA 3LDIA 1JV8A 1ADZA 4BD9B 3CI7A 1CO7I 1NAGA 1D0DA 2DDJA 1BHCA 1DTKA 1DEMA 4NTYB 1D0DB 4WXVC 2M01A 1P2II 4Y10I 3OFWA 2KAII 1OA65 1AALA 4TPII 3BTHI 2PTCI 1JV9A 1EAWB 1T8NB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1BPT A;  2IJO I;  3BYB A;  3AUB A;  3BTE I;  3OTJ I;  3TGJ I;  1TAP A;  2CA7 A;  1BTH P;  3FP7 J;  1P2K I;  1KTH A;  1KNT A;  1P2N B;  4Y0Y I;  1DTX A;  3M7Q B;  1BRB I;  2RA3 C;  3BTG I;  2ZVX A;  3BTK I;  1UUA A;  3D65 I;  4Y0Z I;  1Y62 A;  3AUH A;  4U32 X;  1P2J I;  1DEN A;  3FP8 I;  1P2O B;  1YKT B;  2LFK A;  3U1J E;  3FP6 I;  3BTQ I;  1BTI A;  5JB6 A;  1TOC R;  1CBW D;  1K6U A;  1FAK I;  1G6X A;  4Y11 I;  1PIT A;  2M99 A;  3AUE A;  1EJM B;  3UIR C;  5C67 C;  1T8M B;  1LD6 A;  3L33 E;  2FTL I;  1JC6 A;  4DG4 C;  1BUN B;  2ZJX A;  2J6D A;  2FI4 I;  2FI3 I;  5JB7 A;  4DTG K;  1KIG I;  3TGI I;  1BIK A;  1ZJD B;  1BZX I;  1BRC I;  1TCP A;  3BTT I;  3WNY A;  2UUY B;  3L3T E;  1P2M B;  2FI5 I;  4BQD A;  2LFL A;  1BZ5 A;  1YLC B;  1P2Q B;  1IRH A;  2FTM B;  3AUG A;  3BTW I;  1BPI A;  3TPI I;  1F7Z I;  1FAN A;  4NTX B;  1OA5 5;  3LDJ A;  3UOU B;  3AUI A;  1YLD B;  2ODY E;  3BTM I;  1T8L B;  7PTI A;  3T62 D;  2R9P E;  1TFX C;  3GYM I;  1SHP A;  2KNT A;  2TPI I;  3P92 E;  4U30 W;  3AUC A;  4ISO B;  4PTI A;  1F5R I;  1AAP A;  1CA0 D;  3LDM A;  1T8O B;  1TAW B;  2DDI A;  3BTD I;  2JOT A;  6PTI A;  2HEX A;  1FY8 I;  1UUB A;  9PTI A;  1ZR0 B;  1BF0 A;  5JB5 A;  8PTI A;  1T7C B;  4BNR I;  2KCR A;  4ISL B;  3TGK I;  1KUN A;  2W8X A;  2TGP I;  3AUD A;  5JB4 A;  3BTF I;  1B0C A;  4WWY C;  1TPA I;  3P95 E;  1LD5 A;  4NTW B;  4ISN B;  5PTI A;  1MTN D;  1YC0 I;  1QLQ A;  2UUX A;  3LDI A;  1JV8 A;  1ADZ A;  4BD9 B;  3CI7 A;  1CO7 I;  1NAG A;  1D0D A;  2DDJ A;  1BHC A;  1DTK A;  1DEM A;  4NTY B;  1D0D B;  4WXV C;  2M01 A;  1P2I I;  4Y10 I;  3OFW A;  2KAI I;  1OA6 5;  1AAL A;  4TPI I;  3BTH I;  2PTC I;  1JV9 A;  1EAW B;  1T8N B; 
#chains in the Genus database with same CATH topology
 1BPT A;  2IJO I;  3BYB A;  3AUB A;  3BTE I;  3OTJ I;  3TGJ I;  1TAP A;  2CA7 A;  1BTH P;  3FP7 J;  1P2K I;  1KTH A;  1KNT A;  1P2N B;  4Y0Y I;  1DTX A;  3M7Q B;  1BRB I;  2RA3 C;  3BTG I;  2ZVX A;  3BTK I;  1UUA A;  3D65 I;  4Y0Z I;  1Y62 A;  3AUH A;  4U32 X;  1P2J I;  1DEN A;  3FP8 I;  1P2O B;  1YKT B;  2LFK A;  3U1J E;  3FP6 I;  3BTQ I;  1BTI A;  5JB6 A;  1TOC R;  1CBW D;  1K6U A;  1FAK I;  1G6X A;  4Y11 I;  1PIT A;  2M99 A;  3AUE A;  1EJM B;  3UIR C;  5C67 C;  1T8M B;  1LD6 A;  3L33 E;  2FTL I;  1JC6 A;  4DG4 C;  1BUN B;  2ZJX A;  2J6D A;  2FI4 I;  2FI3 I;  5JB7 A;  4DTG K;  1KIG I;  3TGI I;  1BIK A;  1ZJD B;  1BZX I;  1BRC I;  1TCP A;  3BTT I;  3WNY A;  2UUY B;  3L3T E;  1P2M B;  2FI5 I;  4BQD A;  2LFL A;  1BZ5 A;  1YLC B;  1P2Q B;  1IRH A;  2FTM B;  3AUG A;  3BTW I;  1BPI A;  3TPI I;  1F7Z I;  1FAN A;  4NTX B;  1OA5 5;  3LDJ A;  3UOU B;  3AUI A;  1YLD B;  2ODY E;  3BTM I;  1T8L B;  7PTI A;  3T62 D;  2R9P E;  1TFX C;  3GYM I;  1SHP A;  2KNT A;  2TPI I;  3P92 E;  4U30 W;  3AUC A;  4ISO B;  4PTI A;  1F5R I;  1AAP A;  1CA0 D;  3LDM A;  1T8O B;  1TAW B;  2DDI A;  3BTD I;  2JOT A;  6PTI A;  2HEX A;  1FY8 I;  1UUB A;  9PTI A;  1ZR0 B;  1BF0 A;  5JB5 A;  8PTI A;  1T7C B;  4BNR I;  2KCR A;  4ISL B;  3TGK I;  1KUN A;  2W8X A;  2TGP I;  3AUD A;  5JB4 A;  3BTF I;  1B0C A;  4WWY C;  1TPA I;  3P95 E;  1LD5 A;  4NTW B;  4ISN B;  5PTI A;  1MTN D;  1YC0 I;  1QLQ A;  2UUX A;  3LDI A;  1JV8 A;  1ADZ A;  4BD9 B;  3CI7 A;  1CO7 I;  1NAG A;  1D0D A;  2DDJ A;  1BHC A;  1DTK A;  1DEM A;  4NTY B;  1D0D B;  4WXV C;  2M01 A;  1P2I I;  4Y10 I;  3OFW A;  2KAI I;  1OA6 5;  1AAL A;  4TPI I;  3BTH I;  2PTC I;  1JV9 A;  1EAW B;  1T8N B; 
#chains in the Genus database with same CATH homology
 1BPT A;  2IJO I;  3BYB A;  3AUB A;  3BTE I;  3OTJ I;  3TGJ I;  1TAP A;  2CA7 A;  1BTH P;  3FP7 J;  1P2K I;  1KTH A;  1KNT A;  1P2N B;  4Y0Y I;  1DTX A;  3M7Q B;  1BRB I;  2RA3 C;  3BTG I;  2ZVX A;  3BTK I;  1UUA A;  3D65 I;  4Y0Z I;  1Y62 A;  3AUH A;  4U32 X;  1P2J I;  1DEN A;  3FP8 I;  1P2O B;  1YKT B;  2LFK A;  3U1J E;  3FP6 I;  3BTQ I;  1BTI A;  5JB6 A;  1TOC R;  1CBW D;  1K6U A;  1FAK I;  1G6X A;  4Y11 I;  1PIT A;  2M99 A;  3AUE A;  1EJM B;  3UIR C;  5C67 C;  1T8M B;  1LD6 A;  3L33 E;  2FTL I;  1JC6 A;  4DG4 C;  1BUN B;  2ZJX A;  2J6D A;  2FI4 I;  2FI3 I;  5JB7 A;  4DTG K;  1KIG I;  3TGI I;  1BIK A;  1ZJD B;  1BZX I;  1BRC I;  1TCP A;  3BTT I;  3WNY A;  2UUY B;  3L3T E;  1P2M B;  2FI5 I;  4BQD A;  2LFL A;  1BZ5 A;  1YLC B;  1P2Q B;  1IRH A;  2FTM B;  3AUG A;  3BTW I;  1BPI A;  3TPI I;  1F7Z I;  1FAN A;  4NTX B;  1OA5 5;  3LDJ A;  3UOU B;  3AUI A;  1YLD B;  2ODY E;  3BTM I;  1T8L B;  7PTI A;  3T62 D;  2R9P E;  1TFX C;  3GYM I;  1SHP A;  2KNT A;  2TPI I;  3P92 E;  4U30 W;  3AUC A;  4ISO B;  4PTI A;  1F5R I;  1AAP A;  1CA0 D;  3LDM A;  1T8O B;  1TAW B;  2DDI A;  3BTD I;  2JOT A;  6PTI A;  2HEX A;  1FY8 I;  1UUB A;  9PTI A;  1ZR0 B;  1BF0 A;  5JB5 A;  8PTI A;  1T7C B;  4BNR I;  2KCR A;  4ISL B;  3TGK I;  1KUN A;  2W8X A;  2TGP I;  3AUD A;  5JB4 A;  3BTF I;  1B0C A;  4WWY C;  1TPA I;  3P95 E;  1LD5 A;  4NTW B;  4ISN B;  5PTI A;  1MTN D;  1YC0 I;  1QLQ A;  2UUX A;  3LDI A;  1JV8 A;  1ADZ A;  4BD9 B;  3CI7 A;  1CO7 I;  1NAG A;  1D0D A;  2DDJ A;  1BHC A;  1DTK A;  1DEM A;  4NTY B;  1D0D B;  4WXV C;  2M01 A;  1P2I I;  4Y10 I;  3OFW A;  2KAI I;  1OA6 5;  1AAL A;  4TPI I;  3BTH I;  2PTC I;  1JV9 A;  1EAW B;  1T8N B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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