1TWCL

Rna polymerase ii complexed with gtp
Total Genus 0
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
0
sequence length
46
structure length
46
Chain Sequence
b'ATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKARTKRLVQFEAR'

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords DNA-directed RNA polymerase II largest subunit
publication title Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center.
pubmed doi rcsb
molecule tags Transcription
structure length 46
sequence length 46
ec nomenclature
pdb deposition date 2004-06-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF03604 DNA_RNApol_7kD DNA directed RNA polymerase, 7 kDa subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.28.30 Mainly Beta Single Sheet Rubrerythrin, domain 2 RNA polymerase ii, chain L 1twcL00
5FLML 5IYDL 2NVTL 1TWFL 4A3EL 3H3VM 3PO3L 1TWCL 3S17L 4Y52L 4C3JL 3GTLL 3RZDL 3HOXL 3S1QL 4A3BL 2WAQP 2JA8L 4BXXL 4A3ML 1SFOL 3HKZP 2R92L 4C3IL 4A3JL 1TWGL 2E2HL 3GTML 3M3YL 4C3HL 3GTGL 4A3IL 1K83L 3H0GL 4A3LL 3CQZL 3S15L 5M3ML 3GTPL 3S1NL 3GTOL 5IYCL 3M4OL 4A93L 2R93L 5M5XL 2NVXL 4A3GL 1I3QL 3RZOL 2E2JL 5FJ8L 4A3FL 4BY7L 5C4XL 3GTJL 3FKIL 3GTQL 3HOWL 2VUML 2B63L 3HOVL 1TWHL 3S16L 2R7ZL 4QIWP 1R9TL 4X6AL 3PO2L 2WB1P 3HOYL 5M3FL 1Y1WL 2NVYL 1WCML 4Y7NL 4BY1L 1I50L 3GTKL 4C2M1 5IP7L 4AYBP 2JA7L 5IP9L 2Y0SP 5C4JL 3S2HL 5M5YL 2JA5L 4A3CL 4BBSL 1I6HL 3K7AL 4A3DL 2YU9L 1Y1VL 2NVQL 3HOUL 1TWAL 3HOZL 5C3EL 3I4NL 3S2DL 2E2IL 3I4ML 3S1ML 2PMZP 5M5WL 4A3KL 2JA6L 3S14L 3S1RL 5IYBL 4BBRL 5C44L
chains in the Genus database with same CATH superfamily
2NVTL 1TWFL 4A3EL 3PO3L 1IW7D 4AHWA 3S1QL 4BXXL 1S2ZA 1SFOL 3HKZP 4C3IL 4E6YA 1YV1A 5GADc 3GTML 4GS7D 5MGNA 3WWNB 3B08B 1K83L 3H99A 1RDVA 5IY0A 3S15L 2APOB 2A6HD 5IYCL 1PFUA 2B5ID 5MF6A 3P2AA 3M4OL 2NVXL 1PFYA 3RZ6A 2CR8A 2V3BB 2E2JL 1OWCA 4JADA 1ZRPA 3GTQL 2HR5A 2KN9A 3S16L 2M4VA 4POGA 4LHLA 1NXEA 4ZN3B 2PVEA 1NNQA 5DM71 3KYYA 3LWRB 3PO2L 2PYAA 3LNLA 1DVBA 1I50L 1RB9A 1QCVA 2C6BA 3K35A 2BE5D 5IP9L 2Y0SP 4JAFA 4YWLA 1LKPA 1RDGA 3K7AL 2RFKB 2VL6A 2YU9L 2NVQL 2XJPA 2V0EA 3HOZL 1T9PA 3PIP1 3S2DL 2H12A 5MLC3 3I4ML 2V0FA 4A3KL 2A68D 3S14L 5IYBL 1H7VA 4BBRL 5FLML 1B71A 1YK4A 4AR5A 2RDVA 3GTLL 3HJWB 2O5JD 1VZGA 2CKCA 2A6ED 2R92L 1LTLA 4G6BA 1S24A 1NXGA 5JVH1 1R0GA 2PVXA 3LWOB 1FHHA 4A3IL 4U671 1FHMA 3LPEB 1WJVA 3CQZL 1VCXA 2M4YA 3LWPB 3GTOL 3H97A 1B2OA 1B2JA 4A93L 2R93L 2JI2A 4ME3A 3RYGA 1RWDA 1YUZA 4AI3A 2AYJA 3LWVB 4A3FL 4AI2A 2ZIXA 2LCQA 2ERJA 5C4XL 3GTJL 3FKIL 1OWBA 4XGHA 2VUML 2B63L 1DX8A 2HVYC 1IROA 1RYTA 5GAEc 5DM61 1T9OA 4X6AL 3P8BA 1LKMA 1P7PA 2NVYL 1WCML 1S30A 2GMGA 4BY1L 3RZTA 3PWFA 3GTKL 3HJYB 3B0AB 2JA7L 4XXBB 3S2HL 4RXNA 2Z3RB 5EIOC 1YK5A 5M5YL 1BQ8A 2JI3A 5AN9H 1TWAL 3I4NL 2E2IL 5MFZA 5EINC 2PMZP 3MQKB 2L0ZA 4AHYA 3H9CA 3H3VM 4YWMA 1TWCL 5GAHc 4LHNA 3RZDL 4A3BL 2WAQP 2XJRA 2JA8L 4A3ML 2ERSA 3PL5A 4A3JL 3KYUA 2E2HL 5H1Sc 2XJVA 4AI0A 1SMWA 4C3HL 4UY81 1BE7A 2K2DA 3JR7A 2DSXA 1IU6A 3ZG6A 5M5XL 4A3GL 2M6OA 1QQTA 4JAGA 3RZOL 4ZN1B 2PSMC 1R0FA 3A44A 4AHZA 5AI3A 1VZHA 1F4LA 2EY4E 5GAGc 4BY7L 5K2ME 3HOWL 3KYVA 2QL0A 4B8CD 2R7ZL 4QIWP 3QVDA 4K9FA 3HOYL 1Y1WL 1BFYA 2C6AA 3KYWA 2A69D 1BRFA 5IP7L 3LWQB 5AI2A 1CADA 2AUSB 4A3CL 4BBSL 1I6HL 1R0IA 1YUXA 4A3DL 2JI1A 3MPSA 3HOUL 1R0HA 5C3EL 3SS2A 4AR3A 1BQ9A 1SMUA 1SMMA 4AR4A 3S1ML 3NFPI 3PKIA 5M5WL 2JA6L 2MS3A 5C44L 3HAXC 2XJQA 1C09A 2KKDA 5IYDL 3VPBE 2NYDA 3PIO1 3S17L 4Y52L 4C3JL 3HOXL 2XJUA 3QQCE 2M6PA 1E8JA 4AI1A 1TWGL 2AQCA 4TPUA 3M3YL 3MSUA 1VZIA 3GTGL 5RXNA 1PFVA 2XJTA 3H0GL 3WWLA 4A3LL 5M3ML 2CKAA 3GTPL 3S1NL 3PKJA 6RXNA 3FDJA 2XJSA 2J9UB 1PFWA 1JYBA 8RXNA 1I3QL 1Z92B 4V196 5FJ8L 4POFA 1R0JA 1LKOA 3J7Y1 3H9BA 3HOVL 1TWHL 1IRNA 4JAEA 1R9TL 2WB1P 5M3FL 4AR6A 4Y7NL 3PZAA 1ODHA 4C2M1 1RYQA 2PPTA 7RXNA 1PZXA 4AYBP 1CAAA 5C4JL 2Z3QB 2JA5L 5MFPA 4AHXA 3J7Z1 1Y1VL 5JVG1 1QYBA 1IU5A 3IU3I 1B13A 1T9QA 4WFN1 3KYXA 4TVMA 3S1RL
chains in the Genus database with same CATH topology
5FLML 5IYDL 2NVTL 1TWFL 4A3EL 3H3VM 3PO3L 1TWCL 3S17L 4Y52L 4C3JL 3GTLL 3RZDL 3HOXL 3S1QL 4A3BL 2WAQP 2JA8L 4BXXL 4A3ML 1SFOL 3HKZP 2R92L 4C3IL 4A3JL 1TWGL 2E2HL 3GTML 3M3YL 4C3HL 3GTGL 4A3IL 1K83L 3H0GL 4A3LL 3CQZL 3S15L 5M3ML 3GTPL 3S1NL 3GTOL 5IYCL 3M4OL 4A93L 2R93L 5M5XL 2NVXL 4A3GL 1I3QL 3RZOL 2E2JL 5FJ8L 4A3FL 4BY7L 5C4XL 3GTJL 3FKIL 3GTQL 3HOWL 2VUML 2B63L 3HOVL 1TWHL 3S16L 2R7ZL 4QIWP 1R9TL 4X6AL 3PO2L 2WB1P 3HOYL 5M3FL 1Y1WL 2NVYL 1WCML 4Y7NL 4BY1L 1I50L 3GTKL 4C2M1 5IP7L 4AYBP 2JA7L 5IP9L 2Y0SP 5C4JL 3S2HL 5M5YL 2JA5L 4A3CL 4BBSL 1I6HL 3K7AL 4A3DL 2YU9L 1Y1VL 2NVQL 3HOUL 1TWAL 3HOZL 5C3EL 3I4NL 3S2DL 2E2IL 3I4ML 3S1ML 2PMZP 5M5WL 4A3KL 2JA6L 3S14L 3S1RL 5IYBL 4BBRL 5C44L
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5FLM L;  5IYD L;  2NVT L;  1TWF L;  4A3E L;  3H3V M;  3PO3 L;  1TWC L;  3S17 L;  4Y52 L;  4C3J L;  3GTL L;  3RZD L;  3HOX L;  3S1Q L;  4A3B L;  2WAQ P;  2JA8 L;  4BXX L;  4A3M L;  1SFO L;  3HKZ P;  2R92 L;  4C3I L;  4A3J L;  1TWG L;  2E2H L;  3GTM L;  3M3Y L;  4C3H L;  3GTG L;  4A3I L;  1K83 L;  3H0G L;  4A3L L;  3CQZ L;  3S15 L;  5M3M L;  3GTP L;  3S1N L;  3GTO L;  5IYC L;  3M4O L;  4A93 L;  2R93 L;  5M5X L;  2NVX L;  4A3G L;  1I3Q L;  3RZO L;  2E2J L;  5FJ8 L;  4A3F L;  4BY7 L;  5C4X L;  3GTJ L;  3FKI L;  3GTQ L;  3HOW L;  2VUM L;  2B63 L;  3HOV L;  1TWH L;  3S16 L;  2R7Z L;  4QIW P;  1R9T L;  4X6A L;  3PO2 L;  2WB1 P;  3HOY L;  5M3F L;  1Y1W L;  2NVY L;  1WCM L;  4Y7N L;  4BY1 L;  1I50 L;  3GTK L;  4C2M 1;  5IP7 L;  4AYB P;  2JA7 L;  5IP9 L;  2Y0S P;  5C4J L;  3S2H L;  5M5Y L;  2JA5 L;  4A3C L;  4BBS L;  1I6H L;  3K7A L;  4A3D L;  2YU9 L;  1Y1V L;  2NVQ L;  3HOU L;  1TWA L;  3HOZ L;  5C3E L;  3I4N L;  3S2D L;  2E2I L;  3I4M L;  3S1M L;  2PMZ P;  5M5W L;  4A3K L;  2JA6 L;  3S14 L;  3S1R L;  5IYB L;  4BBR L;  5C44 L; 
#chains in the Genus database with same CATH topology
 2NVT L;  1TWF L;  4A3E L;  3PO3 L;  1IW7 D;  4AHW A;  3S1Q L;  4BXX L;  1S2Z A;  1SFO L;  3HKZ P;  4C3I L;  4E6Y A;  1YV1 A;  5GAD c;  3GTM L;  4GS7 D;  5MGN A;  3WWN B;  3B08 B;  1K83 L;  3H99 A;  1RDV A;  5IY0 A;  3S15 L;  2APO B;  2A6H D;  5IYC L;  1PFU A;  2B5I D;  5MF6 A;  3P2A A;  3M4O L;  2NVX L;  1PFY A;  3RZ6 A;  2CR8 A;  2V3B B;  2E2J L;  1OWC A;  4JAD A;  1ZRP A;  3GTQ L;  2HR5 A;  2KN9 A;  3S16 L;  2M4V A;  4POG A;  4LHL A;  1NXE A;  4ZN3 B;  2PVE A;  1NNQ A;  5DM7 1;  3KYY A;  3LWR B;  3PO2 L;  2PYA A;  3LNL A;  1DVB A;  1I50 L;  1RB9 A;  1QCV A;  2C6B A;  3K35 A;  2BE5 D;  5IP9 L;  2Y0S P;  4JAF A;  4YWL A;  1LKP A;  1RDG A;  3K7A L;  2RFK B;  2VL6 A;  2YU9 L;  2NVQ L;  2XJP A;  2V0E A;  3HOZ L;  1T9P A;  3PIP 1;  3S2D L;  2H12 A;  5MLC 3;  3I4M L;  2V0F A;  4A3K L;  2A68 D;  3S14 L;  5IYB L;  1H7V A;  4BBR L;  5FLM L;  1B71 A;  1YK4 A;  4AR5 A;  2RDV A;  3GTL L;  3HJW B;  2O5J D;  1VZG A;  2CKC A;  2A6E D;  2R92 L;  1LTL A;  4G6B A;  1S24 A;  1NXG A;  5JVH 1;  1R0G A;  2PVX A;  3LWO B;  1FHH A;  4A3I L;  4U67 1;  1FHM A;  3LPE B;  1WJV A;  3CQZ L;  1VCX A;  2M4Y A;  3LWP B;  3GTO L;  3H97 A;  1B2O A;  1B2J A;  4A93 L;  2R93 L;  2JI2 A;  4ME3 A;  3RYG A;  1RWD A;  1YUZ A;  4AI3 A;  2AYJ A;  3LWV B;  4A3F L;  4AI2 A;  2ZIX A;  2LCQ A;  2ERJ A;  5C4X L;  3GTJ L;  3FKI L;  1OWB A;  4XGH A;  2VUM L;  2B63 L;  1DX8 A;  2HVY C;  1IRO A;  1RYT A;  5GAE c;  5DM6 1;  1T9O A;  4X6A L;  3P8B A;  1LKM A;  1P7P A;  2NVY L;  1WCM L;  1S30 A;  2GMG A;  4BY1 L;  3RZT A;  3PWF A;  3GTK L;  3HJY B;  3B0A B;  2JA7 L;  4XXB B;  3S2H L;  4RXN A;  2Z3R B;  5EIO C;  1YK5 A;  5M5Y L;  1BQ8 A;  2JI3 A;  5AN9 H;  1TWA L;  3I4N L;  2E2I L;  5MFZ A;  5EIN C;  2PMZ P;  3MQK B;  2L0Z A;  4AHY A;  3H9C A;  3H3V M;  4YWM A;  1TWC L;  5GAH c;  4LHN A;  3RZD L;  4A3B L;  2WAQ P;  2XJR A;  2JA8 L;  4A3M L;  2ERS A;  3PL5 A;  4A3J L;  3KYU A;  2E2H L;  5H1S c;  2XJV A;  4AI0 A;  1SMW A;  4C3H L;  4UY8 1;  1BE7 A;  2K2D A;  3JR7 A;  2DSX A;  1IU6 A;  3ZG6 A;  5M5X L;  4A3G L;  2M6O A;  1QQT A;  4JAG A;  3RZO L;  4ZN1 B;  2PSM C;  1R0F A;  3A44 A;  4AHZ A;  5AI3 A;  1VZH A;  1F4L A;  2EY4 E;  5GAG c;  4BY7 L;  5K2M E;  3HOW L;  3KYV A;  2QL0 A;  4B8C D;  2R7Z L;  4QIW P;  3QVD A;  4K9F A;  3HOY L;  1Y1W L;  1BFY A;  2C6A A;  3KYW A;  2A69 D;  1BRF A;  5IP7 L;  3LWQ B;  5AI2 A;  1CAD A;  2AUS B;  4A3C L;  4BBS L;  1I6H L;  1R0I A;  1YUX A;  4A3D L;  2JI1 A;  3MPS A;  3HOU L;  1R0H A;  5C3E L;  3SS2 A;  4AR3 A;  1BQ9 A;  1SMU A;  1SMM A;  4AR4 A;  3S1M L;  3NFP I;  3PKI A;  5M5W L;  2JA6 L;  2MS3 A;  5C44 L;  3HAX C;  2XJQ A;  1C09 A;  2KKD A;  5IYD L;  3VPB E;  2NYD A;  3PIO 1;  3S17 L;  4Y52 L;  4C3J L;  3HOX L;  2XJU A;  3QQC E;  2M6P A;  1E8J A;  4AI1 A;  1TWG L;  2AQC A;  4TPU A;  3M3Y L;  3MSU A;  1VZI A;  3GTG L;  5RXN A;  1PFV A;  2XJT A;  3H0G L;  3WWL A;  4A3L L;  5M3M L;  2CKA A;  3GTP L;  3S1N L;  3PKJ A;  6RXN A;  3FDJ A;  2XJS A;  2J9U B;  1PFW A;  1JYB A;  8RXN A;  1I3Q L;  1Z92 B;  4V19 6;  5FJ8 L;  4POF A;  1R0J A;  1LKO A;  3J7Y 1;  3H9B A;  3HOV L;  1TWH L;  1IRN A;  4JAE A;  1R9T L;  2WB1 P;  5M3F L;  4AR6 A;  4Y7N L;  3PZA A;  1ODH A;  4C2M 1;  1RYQ A;  2PPT A;  7RXN A;  1PZX A;  4AYB P;  1CAA A;  5C4J L;  2Z3Q B;  2JA5 L;  5MFP A;  4AHX A;  3J7Z 1;  1Y1V L;  5JVG 1;  1QYB A;  1IU5 A;  3IU3 I;  1B13 A;  1T9Q A;  4WFN 1;  3KYX A;  4TVM A;  3S1R L; 
#chains in the Genus database with same CATH homology
 5FLM L;  5IYD L;  2NVT L;  1TWF L;  4A3E L;  3H3V M;  3PO3 L;  1TWC L;  3S17 L;  4Y52 L;  4C3J L;  3GTL L;  3RZD L;  3HOX L;  3S1Q L;  4A3B L;  2WAQ P;  2JA8 L;  4BXX L;  4A3M L;  1SFO L;  3HKZ P;  2R92 L;  4C3I L;  4A3J L;  1TWG L;  2E2H L;  3GTM L;  3M3Y L;  4C3H L;  3GTG L;  4A3I L;  1K83 L;  3H0G L;  4A3L L;  3CQZ L;  3S15 L;  5M3M L;  3GTP L;  3S1N L;  3GTO L;  5IYC L;  3M4O L;  4A93 L;  2R93 L;  5M5X L;  2NVX L;  4A3G L;  1I3Q L;  3RZO L;  2E2J L;  5FJ8 L;  4A3F L;  4BY7 L;  5C4X L;  3GTJ L;  3FKI L;  3GTQ L;  3HOW L;  2VUM L;  2B63 L;  3HOV L;  1TWH L;  3S16 L;  2R7Z L;  4QIW P;  1R9T L;  4X6A L;  3PO2 L;  2WB1 P;  3HOY L;  5M3F L;  1Y1W L;  2NVY L;  1WCM L;  4Y7N L;  4BY1 L;  1I50 L;  3GTK L;  4C2M 1;  5IP7 L;  4AYB P;  2JA7 L;  5IP9 L;  2Y0S P;  5C4J L;  3S2H L;  5M5Y L;  2JA5 L;  4A3C L;  4BBS L;  1I6H L;  3K7A L;  4A3D L;  2YU9 L;  1Y1V L;  2NVQ L;  3HOU L;  1TWA L;  3HOZ L;  5C3E L;  3I4N L;  3S2D L;  2E2I L;  3I4M L;  3S1M L;  2PMZ P;  5M5W L;  4A3K L;  2JA6 L;  3S14 L;  3S1R L;  5IYB L;  4BBR L;  5C44 L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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