1TWCL

Rna polymerase ii complexed with gtp
Total Genus 0
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
0
sequence length
46
structure length
46
Chain Sequence
ATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKARTKRLVQFEAR

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords DNA-directed RNA polymerase II largest subunit
publication title Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center.
pubmed doi rcsb
molecule tags Transcription
structure length 46
sequence length 46
ec nomenclature
pdb deposition date 2004-06-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF03604 DNA_RNApol_7kD DNA directed RNA polymerase, 7 kDa subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.28.30 Mainly Beta Single Sheet Rubrerythrin, domain 2 RNA polymerase ii, chain L 1twcL00
4A3BL 3S17L 5IP9L 4A3DL 3S1ML 3HOVL 3S1NL 4A3CL 3HOUL 4C3JL 1Y1WL 5M5WL 4A3FL 5M5XL 2PMZP 3FKIL 5FJ8L 3S2DL 4C3IL 4A3KL 3GTGL 3GTLL 1TWGL 2VUML 2JA6L 3S14L 2YU9L 1I50L 2NVTL 1R9TL 5M3FL 2NVYL 3I4NL 3M3YL 2NVXL 4BBSL 3I4ML 4A93L 3M4OL 2WAQP 2JA5L 4Y52L 5C44L 1TWAL 5IYCL 3HOZL 3GTQL 4C3HL 5C3EL 2JA8L 3GTJL 3GTML 2R93L 3HOWL 3PO2L 4A3LL 4A3GL 1TWFL 3CQZL 3K7AL 2R92L 2NVQL 2B63L 5IYDL 1K83L 4C2M1 2R7ZL 3GTKL 4BXXL 3PO3L 2E2JL 1I6HL 3HOYL 3S15L 5C4XL 2E2IL 2WB1P 3S1QL 3GTOL 4BY7L 2E2HL 2JA7L 3RZOL 5C4JL 3S2HL 4QIWP 4BBRL 1Y1VL 4AYBP 5FLML 5IYBL 3HOXL 5M5YL 2Y0SP 3GTPL 3S1RL 4A3IL 3S16L 5IP7L 3HKZP 3H3VM 1I3QL 1TWHL 3H0GL 4X6AL 4A3ML 3RZDL 1TWCL 4A3JL 4BY1L 1WCML 1SFOL 4A3EL 5M3ML 4Y7NL
chains in the Genus database with same CATH superfamily
4A3BL 1ZRPA 5IP9L 1B13A 3B08B 3S1NL 1S2ZA 3LPEB 5M5WL 1NNQA 4A3FL 5M5XL 1DVBA 1QQTA 1BRFA 2V0FA 3GTGL 3GTLL 2RDVA 3PIP1 1R0JA 2H12A 2VUML 5MFZA 2JA6L 3S14L 2A6HD 4POGA 1NXGA 5M3FL 3M3YL 3H9CA 1T9QA 3I4ML 2JA5L 4Y52L 3GTQL 4C3HL 3HOWL 5DM71 3PO2L 2A6ED 2PSMC 3SS2A 4LHLA 4JAEA 4AR6A 5IYDL 3PZAA 3NFPI 1OWCA 2WB1P 1WJVA 3MQKB 2BE5D 3WWLA 2A69D 2E2HL 2AYJA 2AUSB 4XXBB 1JYBA 1BQ9A 3LWQB 2M6PA 5M5YL 1PFYA 5EINC 4GS7D 1BQ8A 4YWMA 5IP7L 2LCQA 3P2AA 1R0IA 2PYAA 4U671 1RYQA 1SFOL 5M3ML 4Y7NL 5GADc 1B2OA 2XJPA 2JI1A 1IROA 3HOVL 1YUXA 1LTLA 4AI2A 5EIOC 1Z92B 2PMZP 4RXNA 5FJ8L 4TPUA 2XJTA 2Z3QB 4C3IL 4A3KL 3PWFA 1R0GA 1YUZA 1PFWA 4JAFA 2KKDA 3RZTA 2YU9L 2ERSA 2NVTL 2JI2A 2NVYL 7RXNA 4BBSL 4POFA 3HJWB 1B2JA 3FDJA 4AR5A 3KYXA 3HJYB 3P8BA 5AN9H 1SMMA 3GTML 4ZN3B 1TWFL 2XJUA 4YWLA 2B63L 1K83L 1S30A 4C2M1 4B8CD 2MS3A 3PO3L 2M4YA 5AI3A 2E2JL 1I6HL 1R0FA 3H9BA 2J9UB 1IW7D 3LWRB 1F4LA 2HR5A 4AR4A 4AYBP 1ODHA 4JADA 1YK4A 1RDVA 3S1RL 3J7Y1 2CKCA 3HAXC 1VZIA 3WWNB 4AHWA 3LWOB 1VZGA 4X6AL 1RDGA 4AHZA 3QVDA 1QCVA 1RWDA 2B5ID 5JVG1 2CR8A 3H97A 3KYWA 1H7VA 2PPTA 3S1ML 1R0HA 2ZIXA 4A3CL 4C3JL 1Y1WL 1E8JA 3PL5A 1OWBA 4AI3A 3FKIL 5MF6A 1TWGL 1DX8A 1QYBA 2M4VA 5H1Sc 1I50L 2K2DA 1P7PA 5MLC3 1RB9A 1YV1A 3A44A 5C44L 5IYCL 1SMWA 4V196 4AI0A 1CADA 5GAHc 1LKMA 2XJQA 2V0EA 5C3EL 1FHHA 3GTJL 2R93L 4A3GL 3PIO1 4AHYA 2R92L 2NVQL 1BFYA 2AQCA 2L0ZA 3IU3I 2HVYC 3HOYL 4E6YA 2XJRA 5DM61 1NXEA 3S1QL 4BY7L 3RZOL 1IU6A 4QIWP 4BBRL 5FLML 3HOXL 2Y0SP 3KYYA 2DSXA 3GTPL 3HKZP 1I3QL 4AI1A 1TWHL 6RXNA 4A3ML 3VPBE 2KN9A 1TWCL 4A3JL 1WCML 2C6BA 2ERJA 2C6AA 2CKAA 4ZN1B 2Z3RB 3LWPB 3S17L 1RYTA 4A3DL 3KYUA 1SMUA 3HOUL 2RFKB 5JVH1 4LHNA 3S2DL 5GAGc 3K35A 3PKIA 1R9TL 1PZXA 3MPSA 3I4NL 5IY0A 2NVXL 5MFPA 3B0AB 4A93L 1BE7A 3M4OL 2WAQP 2A68D 4JAGA 1IRNA 1TWAL 4K9FA 3HOZL 1PFVA 5AI2A 5GAEc 1CAAA 8RXNA 2JA8L 3LNLA 2GMGA 3ZG6A 4G6BA 4A3LL 1FHMA 4UY81 3CQZL 1YK5A 1LKOA 2EY4E 3K7AL 4ME3A 4XGHA 2V3BB 2R7ZL 3GTKL 3J7Z1 4BXXL 3RYGA 3PKJA 1IU5A 3S15L 1VCXA 5C4XL 2E2IL 3KYVA 3MSUA 3JR7A 3GTOL 5RXNA 3LWVB 2JA7L 4AR3A 5C4JL 1B71A 5K2ME 3S2HL 1PFUA 1Y1VL 5IYBL 5MGNA 1T9PA 2NYDA 1S24A 1VZHA 3S16L 4A3IL 2PVEA 2PVXA 4AHXA 4TVMA 1T9OA 3H99A 2O5JD 3H3VM 2XJSA 2QL0A 3H0GL 2APOB 2M6OA 3RZDL 1C09A 4WFN1 1LKPA 3RZ6A 2JI3A 4BY1L 2VL6A 4A3EL 2XJVA 3QQCE
chains in the Genus database with same CATH topology
4A3BL 3S17L 5IP9L 4A3DL 3S1ML 3HOVL 3S1NL 4A3CL 3HOUL 4C3JL 1Y1WL 5M5WL 4A3FL 5M5XL 2PMZP 3FKIL 5FJ8L 3S2DL 4C3IL 4A3KL 3GTGL 3GTLL 1TWGL 2VUML 2JA6L 3S14L 2YU9L 1I50L 2NVTL 1R9TL 5M3FL 2NVYL 3I4NL 3M3YL 2NVXL 4BBSL 3I4ML 4A93L 3M4OL 2WAQP 2JA5L 4Y52L 5C44L 1TWAL 5IYCL 3HOZL 3GTQL 4C3HL 5C3EL 2JA8L 3GTJL 3GTML 2R93L 3HOWL 3PO2L 4A3LL 4A3GL 1TWFL 3CQZL 3K7AL 2R92L 2NVQL 2B63L 5IYDL 1K83L 4C2M1 2R7ZL 3GTKL 4BXXL 3PO3L 2E2JL 1I6HL 3HOYL 3S15L 5C4XL 2E2IL 2WB1P 3S1QL 3GTOL 4BY7L 2E2HL 2JA7L 3RZOL 5C4JL 3S2HL 4QIWP 4BBRL 1Y1VL 4AYBP 5FLML 5IYBL 3HOXL 5M5YL 2Y0SP 3GTPL 3S1RL 4A3IL 3S16L 5IP7L 3HKZP 3H3VM 1I3QL 1TWHL 3H0GL 4X6AL 4A3ML 3RZDL 1TWCL 4A3JL 4BY1L 1WCML 1SFOL 4A3EL 5M3ML 4Y7NL
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4A3B L;  3S17 L;  5IP9 L;  4A3D L;  3S1M L;  3HOV L;  3S1N L;  4A3C L;  3HOU L;  4C3J L;  1Y1W L;  5M5W L;  4A3F L;  5M5X L;  2PMZ P;  3FKI L;  5FJ8 L;  3S2D L;  4C3I L;  4A3K L;  3GTG L;  3GTL L;  1TWG L;  2VUM L;  2JA6 L;  3S14 L;  2YU9 L;  1I50 L;  2NVT L;  1R9T L;  5M3F L;  2NVY L;  3I4N L;  3M3Y L;  2NVX L;  4BBS L;  3I4M L;  4A93 L;  3M4O L;  2WAQ P;  2JA5 L;  4Y52 L;  5C44 L;  1TWA L;  5IYC L;  3HOZ L;  3GTQ L;  4C3H L;  5C3E L;  2JA8 L;  3GTJ L;  3GTM L;  2R93 L;  3HOW L;  3PO2 L;  4A3L L;  4A3G L;  1TWF L;  3CQZ L;  3K7A L;  2R92 L;  2NVQ L;  2B63 L;  5IYD L;  1K83 L;  4C2M 1;  2R7Z L;  3GTK L;  4BXX L;  3PO3 L;  2E2J L;  1I6H L;  3HOY L;  3S15 L;  5C4X L;  2E2I L;  2WB1 P;  3S1Q L;  3GTO L;  4BY7 L;  2E2H L;  2JA7 L;  3RZO L;  5C4J L;  3S2H L;  4QIW P;  4BBR L;  1Y1V L;  4AYB P;  5FLM L;  5IYB L;  3HOX L;  5M5Y L;  2Y0S P;  3GTP L;  3S1R L;  4A3I L;  3S16 L;  5IP7 L;  3HKZ P;  3H3V M;  1I3Q L;  1TWH L;  3H0G L;  4X6A L;  4A3M L;  3RZD L;  1TWC L;  4A3J L;  4BY1 L;  1WCM L;  1SFO L;  4A3E L;  5M3M L;  4Y7N L; 
#chains in the Genus database with same CATH topology
 4A3B L;  1ZRP A;  5IP9 L;  1B13 A;  3B08 B;  3S1N L;  1S2Z A;  3LPE B;  5M5W L;  1NNQ A;  4A3F L;  5M5X L;  1DVB A;  1QQT A;  1BRF A;  2V0F A;  3GTG L;  3GTL L;  2RDV A;  3PIP 1;  1R0J A;  2H12 A;  2VUM L;  5MFZ A;  2JA6 L;  3S14 L;  2A6H D;  4POG A;  1NXG A;  5M3F L;  3M3Y L;  3H9C A;  1T9Q A;  3I4M L;  2JA5 L;  4Y52 L;  3GTQ L;  4C3H L;  3HOW L;  5DM7 1;  3PO2 L;  2A6E D;  2PSM C;  3SS2 A;  4LHL A;  4JAE A;  4AR6 A;  5IYD L;  3PZA A;  3NFP I;  1OWC A;  2WB1 P;  1WJV A;  3MQK B;  2BE5 D;  3WWL A;  2A69 D;  2E2H L;  2AYJ A;  2AUS B;  4XXB B;  1JYB A;  1BQ9 A;  3LWQ B;  2M6P A;  5M5Y L;  1PFY A;  5EIN C;  4GS7 D;  1BQ8 A;  4YWM A;  5IP7 L;  2LCQ A;  3P2A A;  1R0I A;  2PYA A;  4U67 1;  1RYQ A;  1SFO L;  5M3M L;  4Y7N L;  5GAD c;  1B2O A;  2XJP A;  2JI1 A;  1IRO A;  3HOV L;  1YUX A;  1LTL A;  4AI2 A;  5EIO C;  1Z92 B;  2PMZ P;  4RXN A;  5FJ8 L;  4TPU A;  2XJT A;  2Z3Q B;  4C3I L;  4A3K L;  3PWF A;  1R0G A;  1YUZ A;  1PFW A;  4JAF A;  2KKD A;  3RZT A;  2YU9 L;  2ERS A;  2NVT L;  2JI2 A;  2NVY L;  7RXN A;  4BBS L;  4POF A;  3HJW B;  1B2J A;  3FDJ A;  4AR5 A;  3KYX A;  3HJY B;  3P8B A;  5AN9 H;  1SMM A;  3GTM L;  4ZN3 B;  1TWF L;  2XJU A;  4YWL A;  2B63 L;  1K83 L;  1S30 A;  4C2M 1;  4B8C D;  2MS3 A;  3PO3 L;  2M4Y A;  5AI3 A;  2E2J L;  1I6H L;  1R0F A;  3H9B A;  2J9U B;  1IW7 D;  3LWR B;  1F4L A;  2HR5 A;  4AR4 A;  4AYB P;  1ODH A;  4JAD A;  1YK4 A;  1RDV A;  3S1R L;  3J7Y 1;  2CKC A;  3HAX C;  1VZI A;  3WWN B;  4AHW A;  3LWO B;  1VZG A;  4X6A L;  1RDG A;  4AHZ A;  3QVD A;  1QCV A;  1RWD A;  2B5I D;  5JVG 1;  2CR8 A;  3H97 A;  3KYW A;  1H7V A;  2PPT A;  3S1M L;  1R0H A;  2ZIX A;  4A3C L;  4C3J L;  1Y1W L;  1E8J A;  3PL5 A;  1OWB A;  4AI3 A;  3FKI L;  5MF6 A;  1TWG L;  1DX8 A;  1QYB A;  2M4V A;  5H1S c;  1I50 L;  2K2D A;  1P7P A;  5MLC 3;  1RB9 A;  1YV1 A;  3A44 A;  5C44 L;  5IYC L;  1SMW A;  4V19 6;  4AI0 A;  1CAD A;  5GAH c;  1LKM A;  2XJQ A;  2V0E A;  5C3E L;  1FHH A;  3GTJ L;  2R93 L;  4A3G L;  3PIO 1;  4AHY A;  2R92 L;  2NVQ L;  1BFY A;  2AQC A;  2L0Z A;  3IU3 I;  2HVY C;  3HOY L;  4E6Y A;  2XJR A;  5DM6 1;  1NXE A;  3S1Q L;  4BY7 L;  3RZO L;  1IU6 A;  4QIW P;  4BBR L;  5FLM L;  3HOX L;  2Y0S P;  3KYY A;  2DSX A;  3GTP L;  3HKZ P;  1I3Q L;  4AI1 A;  1TWH L;  6RXN A;  4A3M L;  3VPB E;  2KN9 A;  1TWC L;  4A3J L;  1WCM L;  2C6B A;  2ERJ A;  2C6A A;  2CKA A;  4ZN1 B;  2Z3R B;  3LWP B;  3S17 L;  1RYT A;  4A3D L;  3KYU A;  1SMU A;  3HOU L;  2RFK B;  5JVH 1;  4LHN A;  3S2D L;  5GAG c;  3K35 A;  3PKI A;  1R9T L;  1PZX A;  3MPS A;  3I4N L;  5IY0 A;  2NVX L;  5MFP A;  3B0A B;  4A93 L;  1BE7 A;  3M4O L;  2WAQ P;  2A68 D;  4JAG A;  1IRN A;  1TWA L;  4K9F A;  3HOZ L;  1PFV A;  5AI2 A;  5GAE c;  1CAA A;  8RXN A;  2JA8 L;  3LNL A;  2GMG A;  3ZG6 A;  4G6B A;  4A3L L;  1FHM A;  4UY8 1;  3CQZ L;  1YK5 A;  1LKO A;  2EY4 E;  3K7A L;  4ME3 A;  4XGH A;  2V3B B;  2R7Z L;  3GTK L;  3J7Z 1;  4BXX L;  3RYG A;  3PKJ A;  1IU5 A;  3S15 L;  1VCX A;  5C4X L;  2E2I L;  3KYV A;  3MSU A;  3JR7 A;  3GTO L;  5RXN A;  3LWV B;  2JA7 L;  4AR3 A;  5C4J L;  1B71 A;  5K2M E;  3S2H L;  1PFU A;  1Y1V L;  5IYB L;  5MGN A;  1T9P A;  2NYD A;  1S24 A;  1VZH A;  3S16 L;  4A3I L;  2PVE A;  2PVX A;  4AHX A;  4TVM A;  1T9O A;  3H99 A;  2O5J D;  3H3V M;  2XJS A;  2QL0 A;  3H0G L;  2APO B;  2M6O A;  3RZD L;  1C09 A;  4WFN 1;  1LKP A;  3RZ6 A;  2JI3 A;  4BY1 L;  2VL6 A;  4A3E L;  2XJV A;  3QQC E; 
#chains in the Genus database with same CATH homology
 4A3B L;  3S17 L;  5IP9 L;  4A3D L;  3S1M L;  3HOV L;  3S1N L;  4A3C L;  3HOU L;  4C3J L;  1Y1W L;  5M5W L;  4A3F L;  5M5X L;  2PMZ P;  3FKI L;  5FJ8 L;  3S2D L;  4C3I L;  4A3K L;  3GTG L;  3GTL L;  1TWG L;  2VUM L;  2JA6 L;  3S14 L;  2YU9 L;  1I50 L;  2NVT L;  1R9T L;  5M3F L;  2NVY L;  3I4N L;  3M3Y L;  2NVX L;  4BBS L;  3I4M L;  4A93 L;  3M4O L;  2WAQ P;  2JA5 L;  4Y52 L;  5C44 L;  1TWA L;  5IYC L;  3HOZ L;  3GTQ L;  4C3H L;  5C3E L;  2JA8 L;  3GTJ L;  3GTM L;  2R93 L;  3HOW L;  3PO2 L;  4A3L L;  4A3G L;  1TWF L;  3CQZ L;  3K7A L;  2R92 L;  2NVQ L;  2B63 L;  5IYD L;  1K83 L;  4C2M 1;  2R7Z L;  3GTK L;  4BXX L;  3PO3 L;  2E2J L;  1I6H L;  3HOY L;  3S15 L;  5C4X L;  2E2I L;  2WB1 P;  3S1Q L;  3GTO L;  4BY7 L;  2E2H L;  2JA7 L;  3RZO L;  5C4J L;  3S2H L;  4QIW P;  4BBR L;  1Y1V L;  4AYB P;  5FLM L;  5IYB L;  3HOX L;  5M5Y L;  2Y0S P;  3GTP L;  3S1R L;  4A3I L;  3S16 L;  5IP7 L;  3HKZ P;  3H3V M;  1I3Q L;  1TWH L;  3H0G L;  4X6A L;  4A3M L;  3RZD L;  1TWC L;  4A3J L;  4BY1 L;  1WCM L;  1SFO L;  4A3E L;  5M3M L;  4Y7N L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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