1TWHL

Rna polymerase ii complexed with 2'datp
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
46
structure length
46
Chain Sequence
b'ATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKARTKRLVQFEAR'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords DNA-directed RNA polymerase II largest subunit
publication title Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center.
pubmed doi rcsb
molecule tags Transcription
total genus 1
structure length 46
sequence length 46
ec nomenclature
pdb deposition date 2004-06-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF03604 DNA_RNApol_7kD DNA directed RNA polymerase, 7 kDa subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.28.30 Mainly Beta Single Sheet Rubrerythrin, domain 2 RNA polymerase ii, chain L 1twhL00
4C3HL 1I50L 2NVYL 1I6HL 1TWAL 4A3JL 5IYBL 3S1QL 4A3IL 5M5YL 3GTOL 3I4NL 5C3EL 4BY7L 3S16L 3S2HL 4Y7NL 3GTQL 5M5WL 1WCML 4A3CL 4BBSL 2YU9L 3S17L 1I3QL 5IYCL 3HOVL 3S2DL 5M5XL 4A93L 2JA5L 3FKIL 4A3ML 2R93L 4C2M1 2R7ZL 3GTGL 3RZDL 1TWCL 4C3IL 3GTPL 3HOZL 5FJ8L 2WAQP 2NVXL 1K83L 3GTKL 2NVQL 1TWGL 3HOUL 3HOXL 3S1ML 3PO3L 5IP7L 2B63L 2E2HL 3PO2L 3S14L 3S1RL 2JA7L 5M3FL 1R9TL 1TWFL 1Y1WL 3HOYL 5M3ML 5C44L 1SFOL 2R92L 3H0GL 4AYBP 3RZOL 4A3BL 4BXXL 1TWHL 3H3VM 3GTLL 3GTJL 3GTML 2JA8L 5C4XL 4X6AL 5IYDL 4A3KL 3CQZL 4A3EL 2E2JL 3S1NL 4QIWP 2PMZP 3K7AL 4A3FL 5FLML 3I4ML 2E2IL 4BY1L 5IP9L 2WB1P 3M3YL 3HOWL 4A3LL 4Y52L 1Y1VL 4A3GL 2JA6L 2VUML 2NVTL 3S15L 4BBRL 4A3DL 4C3JL 5C4JL 3HKZP 2Y0SP 3M4OL
chains in the Genus database with same CATH superfamily
2V0EA 1I50L 2CKAA 1I6HL 3KYYA 2RFKB 4A3JL 1LKMA 3S1QL 1IROA 5IY0A 2V3BB 1PFUA 2C6BA 1JYBA 3FDJA 3HKZP 1DVBA 5M5WL 3IU3I 4TPUA 3PIO1 1B71A 7RXNA 3B08B 2ZIXA 1P7PA 4GS7D 1FHMA 4A3ML 5MGNA 2R93L 4C2M1 5RXNA 2R7ZL 3H97A 5JVH1 3HOZL 5FJ8L 1H7VA 2NVXL 1C09A 2V0FA 1IU6A 1PZXA 3P8BA 3HOYL 2A6ED 5C44L 3H0GL 4BXXL 2XJVA 4JAFA 3RZ6A 3J7Y1 1OWBA 2A69D 2LCQA 4AHYA 1IW7D 5DM61 3K7AL 2ERJA 4RXNA 5FLML 4BY1L 5IP9L 2WB1P 4AHXA 3M3YL 3HJWB 3HOWL 1SMUA 2M4YA 3ZG6A 4A3GL 2H12A 3PKJA 2NYDA 1T9OA 3NFPI 2AUSB 1T9PA 1YK5A 1RB9A 2Z3RB 4U671 6RXNA 2GMGA 3J7Z1 4LHNA 4WFN1 3QQCE 5M5YL 3GTOL 1WJVA 5C3EL 2APOB 3S2HL 3SS2A 1NXEA 3KYVA 2CR8A 2HR5A 3HAXC 3GTQL 2M6PA 2BE5D 2ERSA 3PWFA 3LNLA 1I3QL 1SMWA 2MS3A 4AI3A 2J9UB 5DM71 2QL0A 1ODHA 3S2DL 1NNQA 1B2OA 3LWPB 4A93L 2JA5L 1IU5A 4XGHA 2A6HD 5MF6A 3GTGL 5GADc 1RWDA 1VCXA 1OWCA 1VZGA 4TVMA 5GAEc 2KN9A 3GTKL 2NVQL 3HOXL 3PO3L 5IP7L 2E2HL 2A68D 2JA7L 2HVYC 4G6BA 4XXBB 1R0JA 1B2JA 2XJRA 1Y1WL 2XJTA 1QQTA 5M3ML 3RZTA 4AI2A 1DX8A 2EY4E 4K9FA 4A3BL 4ZN3B 3H99A 3RYGA 3LWQB 2C6AA 3GTJL 1NXGA 5C4XL 4A3KL 3CQZL 3WWLA 1T9QA 2E2JL 3A44A 2PMZP 1B13A 3I4ML 2E2IL 3JR7A 4Y52L 1S24A 5MFPA 2JA6L 2PVXA 1CAAA 2VUML 2PVEA 3S15L 4A3DL 1F4LA 5JVG1 3H9BA 4C3JL 5C4JL 2B5ID 2RDVA 3M4OL 4C3HL 2NVYL 3KYUA 2M4VA 4AHWA 4AR6A 1R0IA 4POFA 4A3IL 3PL5A 1RDVA 3I4NL 3MSUA 2L0ZA 2PYAA 4JADA 1SMMA 1BQ8A 2XJUA 2JI2A 4BBSL 1FHHA 3S17L 3HOVL 1BE7A 1QYBA 1R0HA 5M5XL 2M6OA 2XJSA 3FKIL 3P2AA 4YWLA 3HJYB 2XJQA 3RZDL 1TWCL 4C3IL 4AHZA 1Z92B 2CKCA 3HOUL 3S1ML 2XJPA 2DSXA 4JAGA 1LKPA 3S14L 1RYQA 3S1RL 5M3FL 1TWFL 3MQKB 3VPBE 1VZHA 2R92L 4AYBP 5GAGc 2K2DA 3K35A 1LTLA 2AQCA 4V196 5H1Sc 1TWHL 2JI3A 5MFZA 3GTLL 4AR5A 4AR4A 2AYJA 4ZN1B 2JA8L 1PFVA 1VZIA 4X6AL 5GAHc 4A3EL 5MLC3 3S1NL 4QIWP 5AN9H 5EIOC 2PPTA 4JAEA 5K2ME 4ME3A 3LWOB 1R0GA 4A3LL 1YK4A 1Y1VL 1YUZA 2KKDA 2NVTL 2JI1A 1BRFA 2Y0SP 3B0AB 1YV1A 1CADA 4POGA 1TWAL 3H9CA 1R0FA 5IYBL 1RDGA 4B8CD 2VL6A 1IRNA 1RYTA 3WWNB 2PSMC 4BY7L 3S16L 3PIP1 4Y7NL 3LWRB 3LWVB 1WCML 3PZAA 4A3CL 2YU9L 1YUXA 8RXNA 5IYCL 4AI1A 1S2ZA 3QVDA 3GTPL 1ZRPA 5AI2A 2WAQP 4AI0A 1PFYA 1K83L 2O5JD 1TWGL 2B63L 3LPEB 3KYWA 5EINC 3PO2L 4UY81 2Z3QB 4YWMA 1R9TL 3KYXA 1BFYA 1LKOA 1SFOL 1S30A 1PFWA 3RZOL 3H3VM 3GTML 5AI3A 1BQ9A 5IYDL 1QCVA 4AR3A 4A3FL 3PKIA 3MPSA 4BBRL 4LHLA 4E6YA 1E8JA
chains in the Genus database with same CATH topology
4C3HL 1I50L 2NVYL 1I6HL 1TWAL 4A3JL 5IYBL 3S1QL 4A3IL 5M5YL 3GTOL 3I4NL 5C3EL 4BY7L 3S16L 3S2HL 4Y7NL 3GTQL 5M5WL 1WCML 4A3CL 4BBSL 2YU9L 3S17L 1I3QL 5IYCL 3HOVL 3S2DL 5M5XL 4A93L 2JA5L 3FKIL 4A3ML 2R93L 4C2M1 2R7ZL 3GTGL 3RZDL 1TWCL 4C3IL 3GTPL 3HOZL 5FJ8L 2WAQP 2NVXL 1K83L 3GTKL 2NVQL 1TWGL 3HOUL 3HOXL 3S1ML 3PO3L 5IP7L 2B63L 2E2HL 3PO2L 3S14L 3S1RL 2JA7L 5M3FL 1R9TL 1TWFL 1Y1WL 3HOYL 5M3ML 5C44L 1SFOL 2R92L 3H0GL 4AYBP 3RZOL 4A3BL 4BXXL 1TWHL 3H3VM 3GTLL 3GTJL 3GTML 2JA8L 5C4XL 4X6AL 5IYDL 4A3KL 3CQZL 4A3EL 2E2JL 3S1NL 4QIWP 2PMZP 3K7AL 4A3FL 5FLML 3I4ML 2E2IL 4BY1L 5IP9L 2WB1P 3M3YL 3HOWL 4A3LL 4Y52L 1Y1VL 4A3GL 2JA6L 2VUML 2NVTL 3S15L 4BBRL 4A3DL 4C3JL 5C4JL 3HKZP 2Y0SP 3M4OL
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4C3H L;  1I50 L;  2NVY L;  1I6H L;  1TWA L;  4A3J L;  5IYB L;  3S1Q L;  4A3I L;  5M5Y L;  3GTO L;  3I4N L;  5C3E L;  4BY7 L;  3S16 L;  3S2H L;  4Y7N L;  3GTQ L;  5M5W L;  1WCM L;  4A3C L;  4BBS L;  2YU9 L;  3S17 L;  1I3Q L;  5IYC L;  3HOV L;  3S2D L;  5M5X L;  4A93 L;  2JA5 L;  3FKI L;  4A3M L;  2R93 L;  4C2M 1;  2R7Z L;  3GTG L;  3RZD L;  1TWC L;  4C3I L;  3GTP L;  3HOZ L;  5FJ8 L;  2WAQ P;  2NVX L;  1K83 L;  3GTK L;  2NVQ L;  1TWG L;  3HOU L;  3HOX L;  3S1M L;  3PO3 L;  5IP7 L;  2B63 L;  2E2H L;  3PO2 L;  3S14 L;  3S1R L;  2JA7 L;  5M3F L;  1R9T L;  1TWF L;  1Y1W L;  3HOY L;  5M3M L;  5C44 L;  1SFO L;  2R92 L;  3H0G L;  4AYB P;  3RZO L;  4A3B L;  4BXX L;  1TWH L;  3H3V M;  3GTL L;  3GTJ L;  3GTM L;  2JA8 L;  5C4X L;  4X6A L;  5IYD L;  4A3K L;  3CQZ L;  4A3E L;  2E2J L;  3S1N L;  4QIW P;  2PMZ P;  3K7A L;  4A3F L;  5FLM L;  3I4M L;  2E2I L;  4BY1 L;  5IP9 L;  2WB1 P;  3M3Y L;  3HOW L;  4A3L L;  4Y52 L;  1Y1V L;  4A3G L;  2JA6 L;  2VUM L;  2NVT L;  3S15 L;  4BBR L;  4A3D L;  4C3J L;  5C4J L;  3HKZ P;  2Y0S P;  3M4O L; 
#chains in the Genus database with same CATH topology
 2V0E A;  1I50 L;  2CKA A;  1I6H L;  3KYY A;  2RFK B;  4A3J L;  1LKM A;  3S1Q L;  1IRO A;  5IY0 A;  2V3B B;  1PFU A;  2C6B A;  1JYB A;  3FDJ A;  3HKZ P;  1DVB A;  5M5W L;  3IU3 I;  4TPU A;  3PIO 1;  1B71 A;  7RXN A;  3B08 B;  2ZIX A;  1P7P A;  4GS7 D;  1FHM A;  4A3M L;  5MGN A;  2R93 L;  4C2M 1;  5RXN A;  2R7Z L;  3H97 A;  5JVH 1;  3HOZ L;  5FJ8 L;  1H7V A;  2NVX L;  1C09 A;  2V0F A;  1IU6 A;  1PZX A;  3P8B A;  3HOY L;  2A6E D;  5C44 L;  3H0G L;  4BXX L;  2XJV A;  4JAF A;  3RZ6 A;  3J7Y 1;  1OWB A;  2A69 D;  2LCQ A;  4AHY A;  1IW7 D;  5DM6 1;  3K7A L;  2ERJ A;  4RXN A;  5FLM L;  4BY1 L;  5IP9 L;  2WB1 P;  4AHX A;  3M3Y L;  3HJW B;  3HOW L;  1SMU A;  2M4Y A;  3ZG6 A;  4A3G L;  2H12 A;  3PKJ A;  2NYD A;  1T9O A;  3NFP I;  2AUS B;  1T9P A;  1YK5 A;  1RB9 A;  2Z3R B;  4U67 1;  6RXN A;  2GMG A;  3J7Z 1;  4LHN A;  4WFN 1;  3QQC E;  5M5Y L;  3GTO L;  1WJV A;  5C3E L;  2APO B;  3S2H L;  3SS2 A;  1NXE A;  3KYV A;  2CR8 A;  2HR5 A;  3HAX C;  3GTQ L;  2M6P A;  2BE5 D;  2ERS A;  3PWF A;  3LNL A;  1I3Q L;  1SMW A;  2MS3 A;  4AI3 A;  2J9U B;  5DM7 1;  2QL0 A;  1ODH A;  3S2D L;  1NNQ A;  1B2O A;  3LWP B;  4A93 L;  2JA5 L;  1IU5 A;  4XGH A;  2A6H D;  5MF6 A;  3GTG L;  5GAD c;  1RWD A;  1VCX A;  1OWC A;  1VZG A;  4TVM A;  5GAE c;  2KN9 A;  3GTK L;  2NVQ L;  3HOX L;  3PO3 L;  5IP7 L;  2E2H L;  2A68 D;  2JA7 L;  2HVY C;  4G6B A;  4XXB B;  1R0J A;  1B2J A;  2XJR A;  1Y1W L;  2XJT A;  1QQT A;  5M3M L;  3RZT A;  4AI2 A;  1DX8 A;  2EY4 E;  4K9F A;  4A3B L;  4ZN3 B;  3H99 A;  3RYG A;  3LWQ B;  2C6A A;  3GTJ L;  1NXG A;  5C4X L;  4A3K L;  3CQZ L;  3WWL A;  1T9Q A;  2E2J L;  3A44 A;  2PMZ P;  1B13 A;  3I4M L;  2E2I L;  3JR7 A;  4Y52 L;  1S24 A;  5MFP A;  2JA6 L;  2PVX A;  1CAA A;  2VUM L;  2PVE A;  3S15 L;  4A3D L;  1F4L A;  5JVG 1;  3H9B A;  4C3J L;  5C4J L;  2B5I D;  2RDV A;  3M4O L;  4C3H L;  2NVY L;  3KYU A;  2M4V A;  4AHW A;  4AR6 A;  1R0I A;  4POF A;  4A3I L;  3PL5 A;  1RDV A;  3I4N L;  3MSU A;  2L0Z A;  2PYA A;  4JAD A;  1SMM A;  1BQ8 A;  2XJU A;  2JI2 A;  4BBS L;  1FHH A;  3S17 L;  3HOV L;  1BE7 A;  1QYB A;  1R0H A;  5M5X L;  2M6O A;  2XJS A;  3FKI L;  3P2A A;  4YWL A;  3HJY B;  2XJQ A;  3RZD L;  1TWC L;  4C3I L;  4AHZ A;  1Z92 B;  2CKC A;  3HOU L;  3S1M L;  2XJP A;  2DSX A;  4JAG A;  1LKP A;  3S14 L;  1RYQ A;  3S1R L;  5M3F L;  1TWF L;  3MQK B;  3VPB E;  1VZH A;  2R92 L;  4AYB P;  5GAG c;  2K2D A;  3K35 A;  1LTL A;  2AQC A;  4V19 6;  5H1S c;  1TWH L;  2JI3 A;  5MFZ A;  3GTL L;  4AR5 A;  4AR4 A;  2AYJ A;  4ZN1 B;  2JA8 L;  1PFV A;  1VZI A;  4X6A L;  5GAH c;  4A3E L;  5MLC 3;  3S1N L;  4QIW P;  5AN9 H;  5EIO C;  2PPT A;  4JAE A;  5K2M E;  4ME3 A;  3LWO B;  1R0G A;  4A3L L;  1YK4 A;  1Y1V L;  1YUZ A;  2KKD A;  2NVT L;  2JI1 A;  1BRF A;  2Y0S P;  3B0A B;  1YV1 A;  1CAD A;  4POG A;  1TWA L;  3H9C A;  1R0F A;  5IYB L;  1RDG A;  4B8C D;  2VL6 A;  1IRN A;  1RYT A;  3WWN B;  2PSM C;  4BY7 L;  3S16 L;  3PIP 1;  4Y7N L;  3LWR B;  3LWV B;  1WCM L;  3PZA A;  4A3C L;  2YU9 L;  1YUX A;  8RXN A;  5IYC L;  4AI1 A;  1S2Z A;  3QVD A;  3GTP L;  1ZRP A;  5AI2 A;  2WAQ P;  4AI0 A;  1PFY A;  1K83 L;  2O5J D;  1TWG L;  2B63 L;  3LPE B;  3KYW A;  5EIN C;  3PO2 L;  4UY8 1;  2Z3Q B;  4YWM A;  1R9T L;  3KYX A;  1BFY A;  1LKO A;  1SFO L;  1S30 A;  1PFW A;  3RZO L;  3H3V M;  3GTM L;  5AI3 A;  1BQ9 A;  5IYD L;  1QCV A;  4AR3 A;  4A3F L;  3PKI A;  3MPS A;  4BBR L;  4LHL A;  4E6Y A;  1E8J A; 
#chains in the Genus database with same CATH homology
 4C3H L;  1I50 L;  2NVY L;  1I6H L;  1TWA L;  4A3J L;  5IYB L;  3S1Q L;  4A3I L;  5M5Y L;  3GTO L;  3I4N L;  5C3E L;  4BY7 L;  3S16 L;  3S2H L;  4Y7N L;  3GTQ L;  5M5W L;  1WCM L;  4A3C L;  4BBS L;  2YU9 L;  3S17 L;  1I3Q L;  5IYC L;  3HOV L;  3S2D L;  5M5X L;  4A93 L;  2JA5 L;  3FKI L;  4A3M L;  2R93 L;  4C2M 1;  2R7Z L;  3GTG L;  3RZD L;  1TWC L;  4C3I L;  3GTP L;  3HOZ L;  5FJ8 L;  2WAQ P;  2NVX L;  1K83 L;  3GTK L;  2NVQ L;  1TWG L;  3HOU L;  3HOX L;  3S1M L;  3PO3 L;  5IP7 L;  2B63 L;  2E2H L;  3PO2 L;  3S14 L;  3S1R L;  2JA7 L;  5M3F L;  1R9T L;  1TWF L;  1Y1W L;  3HOY L;  5M3M L;  5C44 L;  1SFO L;  2R92 L;  3H0G L;  4AYB P;  3RZO L;  4A3B L;  4BXX L;  1TWH L;  3H3V M;  3GTL L;  3GTJ L;  3GTM L;  2JA8 L;  5C4X L;  4X6A L;  5IYD L;  4A3K L;  3CQZ L;  4A3E L;  2E2J L;  3S1N L;  4QIW P;  2PMZ P;  3K7A L;  4A3F L;  5FLM L;  3I4M L;  2E2I L;  4BY1 L;  5IP9 L;  2WB1 P;  3M3Y L;  3HOW L;  4A3L L;  4Y52 L;  1Y1V L;  4A3G L;  2JA6 L;  2VUM L;  2NVT L;  3S15 L;  4BBR L;  4A3D L;  4C3J L;  5C4J L;  3HKZ P;  2Y0S P;  3M4O L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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