1TWQA

Crystal structure of the c-terminal pgn-binding domain of human pgrp-ialpha in complex with pgn analog muramyl tripeptide
Total Genus 53
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
53
sequence length
165
structure length
165
Chain Sequence
VCPNIIKRSAWEARETHCPKMNLPAKYVIIIHTAGTSCTVSTDCQTVVRNIQSFHMDTRNFCDIGYHFLVGQDGGVYEGVGWHIQGSHTYGFNDIALGIAFIGYFVEKPPNAAALEAAQDLIQCAVVEGYLTPNYLLMGHSDVVNILSPGQALYNIISTWPHFKH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis for peptidoglycan binding by peptidoglycan recognition proteins
pubmed doi rcsb
molecule keywords peptidoglycan recognition protein-I-alpha
molecule tags Immune system, membrane protein
source organism Homo sapiens
total genus 53
structure length 165
sequence length 165
ec nomenclature
pdb deposition date 2004-07-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01510 Amidase_2 N-acetylmuramoyl-L-alanine amidase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.80.10 Alpha Beta 3-Layer(aba) Sandwich Lysozyme-like Peptidoglycan recognition protein-like 1twqA00
2XZ8A 2AR3A 2CB3A 3TRUA 1YB0A 3D2ZA 3NW3A 2Y2DA 3D2YA 5E0AA 3T2VA 3CG9A 4IVVA 4OUGA 2Y2CA 3CXAA 2WKXA 3UILA 2EAXA 4KNKA 3LATA 2EAVA 4Q8SA 2XZ4A 2Y2EA 2R2KA 3QS0A 3QV4A 2R90A 3RDRA 4FNNA 1Z6IA 4BXEA 1J3GA 1SK4A 2Y2BA 2F2LX 1SK3A 3USXA 5DWFA 3UMQA 5CTVA 2RKQA 2BH7A 4KNLA 4BOLA 3RT4A 4ORVA 4OLSA 4Q9EA 1AROL 1TWQA 3O4KA 2L47A 1SXRA 3HMBA 4BXJA 4X36A 4Z8IA 5E0BA 4BXDA 3OGXA 4GF9A 4BJ4A 3T39A 3NNOA 1LBAA 1S2JA 1YCKA 2Z9NA 3UMLA 4OPPA 3NG4A 4BPAA 2F2LA 2APHA 3CORA 3QJ1A 2Y28A 3EP1A 4ZXMA 1OHTA 3C2XA
chains in the Genus database with same CATH superfamily
2XZ8A 2AR3A 2CB3A 3TRUA 1YB0A 3D2ZA 3NW3A 2Y2DA 3D2YA 5E0AA 3T2VA 3CG9A 4IVVA 4OUGA 2Y2CA 3CXAA 2WKXA 3UILA 2EAXA 4KNKA 3LATA 2EAVA 4Q8SA 2XZ4A 2Y2EA 2R2KA 3QS0A 3QV4A 2R90A 3RDRA 4FNNA 1Z6IA 4BXEA 1J3GA 1SK4A 2Y2BA 2F2LX 1SK3A 3USXA 5DWFA 3UMQA 5CTVA 2RKQA 2BH7A 4KNLA 4BOLA 3RT4A 4ORVA 4OLSA 4Q9EA 1AROL 1TWQA 3O4KA 2L47A 1SXRA 3HMBA 4BXJA 4X36A 4Z8IA 5E0BA 4BXDA 3OGXA 4GF9A 4BJ4A 3T39A 3NNOA 1LBAA 1S2JA 1YCKA 2Z9NA 3UMLA 4OPPA 3NG4A 4BPAA 2F2LA 2APHA 3CORA 3QJ1A 2Y28A 3EP1A 4ZXMA 1OHTA 3C2XA
chains in the Genus database with same CATH topology
2XZ8A 2AR3A 2CB3A 3TRUA 1YB0A 3D2ZA 3NW3A 2Y2DA 3D2YA 5E0AA 3T2VA 3CG9A 4IVVA 4OUGA 2Y2CA 3CXAA 2WKXA 3UILA 2EAXA 4KNKA 3LATA 2EAVA 4Q8SA 2XZ4A 2Y2EA 2R2KA 3QS0A 3QV4A 2R90A 3RDRA 4FNNA 1Z6IA 4BXEA 1J3GA 1SK4A 2Y2BA 2F2LX 1SK3A 3USXA 5DWFA 3UMQA 5CTVA 2RKQA 2BH7A 4KNLA 4BOLA 3RT4A 4ORVA 4OLSA 4Q9EA 1AROL 1TWQA 3O4KA 2L47A 1SXRA 3HMBA 4BXJA 4X36A 4Z8IA 5E0BA 4BXDA 3OGXA 4GF9A 4BJ4A 3T39A 3NNOA 1LBAA 1S2JA 1YCKA 2Z9NA 3UMLA 4OPPA 3NG4A 4BPAA 2F2LA 2APHA 3CORA 3QJ1A 2Y28A 3EP1A 4ZXMA 1OHTA 3C2XA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XZ8 A;  2AR3 A;  2CB3 A;  3TRU A;  1YB0 A;  3D2Z A;  3NW3 A;  2Y2D A;  3D2Y A;  5E0A A;  3T2V A;  3CG9 A;  4IVV A;  4OUG A;  2Y2C A;  3CXA A;  2WKX A;  3UIL A;  2EAX A;  4KNK A;  3LAT A;  2EAV A;  4Q8S A;  2XZ4 A;  2Y2E A;  2R2K A;  3QS0 A;  3QV4 A;  2R90 A;  3RDR A;  4FNN A;  1Z6I A;  4BXE A;  1J3G A;  1SK4 A;  2Y2B A;  2F2L X;  1SK3 A;  3USX A;  5DWF A;  3UMQ A;  5CTV A;  2RKQ A;  2BH7 A;  4KNL A;  4BOL A;  3RT4 A;  4ORV A;  4OLS A;  4Q9E A;  1ARO L;  1TWQ A;  3O4K A;  2L47 A;  1SXR A;  3HMB A;  4BXJ A;  4X36 A;  4Z8I A;  5E0B A;  4BXD A;  3OGX A;  4GF9 A;  4BJ4 A;  3T39 A;  3NNO A;  1LBA A;  1S2J A;  1YCK A;  2Z9N A;  3UML A;  4OPP A;  3NG4 A;  4BPA A;  2F2L A;  2APH A;  3COR A;  3QJ1 A;  2Y28 A;  3EP1 A;  4ZXM A;  1OHT A;  3C2X A; 
#chains in the Genus database with same CATH topology
 2XZ8 A;  2AR3 A;  2CB3 A;  3TRU A;  1YB0 A;  3D2Z A;  3NW3 A;  2Y2D A;  3D2Y A;  5E0A A;  3T2V A;  3CG9 A;  4IVV A;  4OUG A;  2Y2C A;  3CXA A;  2WKX A;  3UIL A;  2EAX A;  4KNK A;  3LAT A;  2EAV A;  4Q8S A;  2XZ4 A;  2Y2E A;  2R2K A;  3QS0 A;  3QV4 A;  2R90 A;  3RDR A;  4FNN A;  1Z6I A;  4BXE A;  1J3G A;  1SK4 A;  2Y2B A;  2F2L X;  1SK3 A;  3USX A;  5DWF A;  3UMQ A;  5CTV A;  2RKQ A;  2BH7 A;  4KNL A;  4BOL A;  3RT4 A;  4ORV A;  4OLS A;  4Q9E A;  1ARO L;  1TWQ A;  3O4K A;  2L47 A;  1SXR A;  3HMB A;  4BXJ A;  4X36 A;  4Z8I A;  5E0B A;  4BXD A;  3OGX A;  4GF9 A;  4BJ4 A;  3T39 A;  3NNO A;  1LBA A;  1S2J A;  1YCK A;  2Z9N A;  3UML A;  4OPP A;  3NG4 A;  4BPA A;  2F2L A;  2APH A;  3COR A;  3QJ1 A;  2Y28 A;  3EP1 A;  4ZXM A;  1OHT A;  3C2X A; 
#chains in the Genus database with same CATH homology
 2XZ8 A;  2AR3 A;  2CB3 A;  3TRU A;  1YB0 A;  3D2Z A;  3NW3 A;  2Y2D A;  3D2Y A;  5E0A A;  3T2V A;  3CG9 A;  4IVV A;  4OUG A;  2Y2C A;  3CXA A;  2WKX A;  3UIL A;  2EAX A;  4KNK A;  3LAT A;  2EAV A;  4Q8S A;  2XZ4 A;  2Y2E A;  2R2K A;  3QS0 A;  3QV4 A;  2R90 A;  3RDR A;  4FNN A;  1Z6I A;  4BXE A;  1J3G A;  1SK4 A;  2Y2B A;  2F2L X;  1SK3 A;  3USX A;  5DWF A;  3UMQ A;  5CTV A;  2RKQ A;  2BH7 A;  4KNL A;  4BOL A;  3RT4 A;  4ORV A;  4OLS A;  4Q9E A;  1ARO L;  1TWQ A;  3O4K A;  2L47 A;  1SXR A;  3HMB A;  4BXJ A;  4X36 A;  4Z8I A;  5E0B A;  4BXD A;  3OGX A;  4GF9 A;  4BJ4 A;  3T39 A;  3NNO A;  1LBA A;  1S2J A;  1YCK A;  2Z9N A;  3UML A;  4OPP A;  3NG4 A;  4BPA A;  2F2L A;  2APH A;  3COR A;  3QJ1 A;  2Y28 A;  3EP1 A;  4ZXM A;  1OHT A;  3C2X A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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