1TX4A

Rho/rhogap/gdp(dot)alf4 complex
Total Genus 72
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
72
sequence length
196
structure length
196
Chain Sequence
PLPNQQFGVSLQHLQEKNPEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNALHLPAVILKTFLRELPEPLLTFDLYPHVVGFLNIDESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLWAKDAAITLKAINPINTFTKFLLDHQGELF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Complex(gtpase activatn/proto-oncogene)
molecule keywords P50-RHOGAP
publication title Structure at 1.65 A of RhoA and its GTPase-activating protein in complex with a transition-state analogue.
pubmed doi rcsb
source organism Homo sapiens
total genus 72
structure length 196
sequence length 196
ec nomenclature
pdb deposition date 1997-07-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00620 RhoGAP RhoGAP domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.555.10 Mainly Alpha Orthogonal Bundle Phosphatidylinositol 3-kinase; Chain A Rho GTPase activation protein 1tx4A00
5C5SA 3MSXB 5C2JA 2EE4A 5HPYA 5IRCA 1XA6A 1GRNB 1RGPA 1PBWA 3IUGA 2MBGA 3WPQA 2EE5A 3CXLA 3QISA 2XS6A 1TX4A 3WPSA 3EAPA 1F7CA 2NGRB 5JD0A 3W6RA 5JCPA 1OW3A 2OVJA 3KUQA 2QV2A 2OSAA 3BYIA 1AM4A 3FK2A
chains in the Genus database with same CATH superfamily
5C5SA 3MSXB 5C2JA 2EE4A 5HPYA 5IRCA 1XA6A 1GRNB 1RGPA 1PBWA 3IUGA 2MBGA 3WPQA 2EE5A 3CXLA 3QISA 2XS6A 1TX4A 3WPSA 3EAPA 1F7CA 2NGRB 5JD0A 3W6RA 5JCPA 1OW3A 2OVJA 3KUQA 2QV2A 2OSAA 3BYIA 1AM4A 3FK2A
chains in the Genus database with same CATH topology
5C5SA 3MSXB 5C2JA 2EE4A 5HPYA 5IRCA 1XA6A 1GRNB 1RGPA 1PBWA 3IUGA 2MBGA 3WPQA 2EE5A 3CXLA 3QISA 2XS6A 1TX4A 3WPSA 3EAPA 1F7CA 2NGRB 5JD0A 3W6RA 5JCPA 1OW3A 2OVJA 3KUQA 2QV2A 2OSAA 3BYIA 1AM4A 3FK2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5C5S A;  3MSX B;  5C2J A;  2EE4 A;  5HPY A;  5IRC A;  1XA6 A;  1GRN B;  1RGP A;  1PBW A;  3IUG A;  2MBG A;  3WPQ A;  2EE5 A;  3CXL A;  3QIS A;  2XS6 A;  1TX4 A;  3WPS A;  3EAP A;  1F7C A;  2NGR B;  5JD0 A;  3W6R A;  5JCP A;  1OW3 A;  2OVJ A;  3KUQ A;  2QV2 A;  2OSA A;  3BYI A;  1AM4 A;  3FK2 A; 
#chains in the Genus database with same CATH topology
 5C5S A;  3MSX B;  5C2J A;  2EE4 A;  5HPY A;  5IRC A;  1XA6 A;  1GRN B;  1RGP A;  1PBW A;  3IUG A;  2MBG A;  3WPQ A;  2EE5 A;  3CXL A;  3QIS A;  2XS6 A;  1TX4 A;  3WPS A;  3EAP A;  1F7C A;  2NGR B;  5JD0 A;  3W6R A;  5JCP A;  1OW3 A;  2OVJ A;  3KUQ A;  2QV2 A;  2OSA A;  3BYI A;  1AM4 A;  3FK2 A; 
#chains in the Genus database with same CATH homology
 5C5S A;  3MSX B;  5C2J A;  2EE4 A;  5HPY A;  5IRC A;  1XA6 A;  1GRN B;  1RGP A;  1PBW A;  3IUG A;  2MBG A;  3WPQ A;  2EE5 A;  3CXL A;  3QIS A;  2XS6 A;  1TX4 A;  3WPS A;  3EAP A;  1F7C A;  2NGR B;  5JD0 A;  3W6R A;  5JCP A;  1OW3 A;  2OVJ A;  3KUQ A;  2QV2 A;  2OSA A;  3BYI A;  1AM4 A;  3FK2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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