1UCPA

Nmr structure of the pyrin domain of human asc
Total Genus 28
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
91
structure length
91
Chain Sequence
MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFYLETYGAELTANVLRDMGLQEMAGQLQAATHQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The death-domain fold of the ASC PYRIN domain, presenting a basis for PYRIN/PYRIN recognition
pubmed doi rcsb
molecule tags Apoptosis
source organism Homo sapiens
molecule keywords Apoptosis-associated speck-like protein containing a CARD
total genus 28
structure length 91
sequence length 91
ec nomenclature
pdb deposition date 2003-04-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02758 PYRIN PAAD/DAPIN/Pyrin domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 1ucpA00
4P4HI 2N83A 4LWDA 4ZBWA 4N1KA 3YGSP 1ICHA 2DBHA 2MB9A 2VGQA 1CWWA 1DDFA 4IZ7B 2MS7A 2BBZA 2N97A 3EZQB 1FADA 1PN5A 3MOPG 4O6XA 1NGRA 1WH4A 3LQQA 1C15A 2G7RA 4D8OA 4IZAB 4A2QA 4M9SA 1E41A 4O9LA 1WMGA 2D96A 3MOPK 4M9ZA 2M5VA 4E9MA 2OF5H 2N1FA 2B1WA 2YVIA 4JQWA 2HM2Q 2DO9A 4RHWA 4O7QA 2MN4A 2P1HA 2KM6A 2BBRA 2DBDA 3T6PA 3CL3A 2YGSA 4M9XA 2L6AA 1D2ZB 4O9FA 2LWDA 4N1LA 1CY5A 4I16A 2A9IA 2OF5A 4IZ5E 2O71A 2NSNA 1E3YA 3QF2A 1DGNA 2N7ZA 3KATA 2DBFA 1D2ZA 2IB1A 3MOPA 2N80A 2L9MA 3CRDA 4RHWE 3J63A 2LWEA 4F44A 3LQRA 2NZ7A 1YGOA 2LS7A 4N1JA 2KN6A 1Z6TA 2N00A 4NQKA 3J6JA 4UZ0A 1WXPA 4QOBA 2A5YB 4DWNA 1UCPA 4JUPA 4P4HA 1A1WA 2NAQA 2MS8A 1N3KA 2YU0A 4F42A 2F1SA 4FH0A 1A1ZA 2GF5A 3YGSC 2MPCA 4A2WA 4EWIA 3EZQA 2YQFA 2DBGA
chains in the Genus database with same CATH superfamily
4P4HI 2N83A 4LWDA 4ZBWA 4N1KA 3YGSP 1ICHA 2DBHA 2MB9A 2VGQA 1CWWA 1DDFA 4IZ7B 2MS7A 2BBZA 2MJMA 2N97A 3EZQB 1FADA 1PN5A 3MOPG 4O6XA 1NGRA 1WH4A 3LQQA 1C15A 2G7RA 4D8OA 4IZAB 4A2QA 4M9SA 1E41A 4O9LA 1WMGA 2D96A 3MOPK 4M9ZA 2M5VA 4E9MA 2OF5H 2N1FA 2B1WA 2YVIA 4JQWA 2HM2Q 2DO9A 4RHWA 4O7QA 2MN4A 2P1HA 2KM6A 2BBRA 2DBDA 3T6PA 3CL3A 2YGSA 4M9XA 2L6AA 1D2ZB 4O9FA 2LWDA 4N1LA 1CY5A 4I16A 2A9IA 2OF5A 4IZ5E 2O71A 2NSNA 1E3YA 3QF2A 1DGNA 2N7ZA 3KATA 2DBFA 1D2ZA 2IB1A 3MOPA 2N80A 2L9MA 3CRDA 4RHWE 3J63A 2LWEA 4F44A 3LQRA 2NZ7A 1YGOA 2LS7A 4N1JA 2KN6A 1Z6TA 2N00A 4NQKA 3J6JA 4UZ0A 1WXPA 4QOBA 2A5YB 4DWNA 1UCPA 4JUPA 4P4HA 1A1WA 2NAQA 2MS8A 1N3KA 2YU0A 4F42A 2F1SA 4FH0A 1A1ZA 2GF5A 3YGSC 2XV9A 2MPCA 4A2WA 4EWIA 3EZQA 2YQFA 2DBGA
chains in the Genus database with same CATH topology
4P4HI 2N83A 4LWDA 4ZBWA 4N1KA 3YGSP 1ICHA 2DBHA 2MB9A 2VGQA 1CWWA 1DDFA 4IZ7B 2MS7A 2BBZA 2MJMA 2N97A 3EZQB 1FADA 1PN5A 3MOPG 4O6XA 1NGRA 1WH4A 3LQQA 1C15A 2G7RA 4D8OA 4IZAB 4A2QA 4M9SA 1E41A 4O9LA 1WMGA 2D96A 3MOPK 4M9ZA 2M5VA 4E9MA 2OF5H 2N1FA 2B1WA 2YVIA 4JQWA 2HM2Q 2DO9A 4RHWA 4O7QA 2MN4A 2P1HA 2KM6A 2BBRA 2DBDA 3T6PA 3CL3A 2YGSA 4M9XA 2L6AA 1D2ZB 4O9FA 2LWDA 4N1LA 1CY5A 4I16A 2A9IA 2OF5A 4IZ5E 2O71A 2NSNA 1E3YA 3QF2A 1DGNA 2N7ZA 3KATA 2DBFA 1D2ZA 2IB1A 3MOPA 2N80A 2L9MA 3CRDA 4RHWE 3J63A 2LWEA 4F44A 3LQRA 2NZ7A 1YGOA 2LS7A 4N1JA 2KN6A 1Z6TA 2N00A 4NQKA 3J6JA 4UZ0A 1WXPA 4QOBA 2A5YB 4DWNA 1UCPA 4JUPA 4P4HA 1A1WA 2NAQA 2MS8A 1N3KA 2YU0A 4F42A 2F1SA 4FH0A 1A1ZA 2GF5A 3YGSC 2XV9A 2MPCA 4A2WA 4EWIA 3EZQA 2YQFA 2DBGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4P4H I;  2N83 A;  4LWD A;  4ZBW A;  4N1K A;  3YGS P;  1ICH A;  2DBH A;  2MB9 A;  2VGQ A;  1CWW A;  1DDF A;  4IZ7 B;  2MS7 A;  2BBZ A;  2N97 A;  3EZQ B;  1FAD A;  1PN5 A;  3MOP G;  4O6X A;  1NGR A;  1WH4 A;  3LQQ A;  1C15 A;  2G7R A;  4D8O A;  4IZA B;  4A2Q A;  4M9S A;  1E41 A;  4O9L A;  1WMG A;  2D96 A;  3MOP K;  4M9Z A;  2M5V A;  4E9M A;  2OF5 H;  2N1F A;  2B1W A;  2YVI A;  4JQW A;  2HM2 Q;  2DO9 A;  4RHW A;  4O7Q A;  2MN4 A;  2P1H A;  2KM6 A;  2BBR A;  2DBD A;  3T6P A;  3CL3 A;  2YGS A;  4M9X A;  2L6A A;  1D2Z B;  4O9F A;  2LWD A;  4N1L A;  1CY5 A;  4I16 A;  2A9I A;  2OF5 A;  4IZ5 E;  2O71 A;  2NSN A;  1E3Y A;  3QF2 A;  1DGN A;  2N7Z A;  3KAT A;  2DBF A;  1D2Z A;  2IB1 A;  3MOP A;  2N80 A;  2L9M A;  3CRD A;  4RHW E;  3J63 A;  2LWE A;  4F44 A;  3LQR A;  2NZ7 A;  1YGO A;  2LS7 A;  4N1J A;  2KN6 A;  1Z6T A;  2N00 A;  4NQK A;  3J6J A;  4UZ0 A;  1WXP A;  4QOB A;  2A5Y B;  4DWN A;  1UCP A;  4JUP A;  4P4H A;  1A1W A;  2NAQ A;  2MS8 A;  1N3K A;  2YU0 A;  4F42 A;  2F1S A;  4FH0 A;  1A1Z A;  2GF5 A;  3YGS C;  2MPC A;  4A2W A;  4EWI A;  3EZQ A;  2YQF A;  2DBG A; 
#chains in the Genus database with same CATH topology
 4P4H I;  2N83 A;  4LWD A;  4ZBW A;  4N1K A;  3YGS P;  1ICH A;  2DBH A;  2MB9 A;  2VGQ A;  1CWW A;  1DDF A;  4IZ7 B;  2MS7 A;  2BBZ A;  2MJM A;  2N97 A;  3EZQ B;  1FAD A;  1PN5 A;  3MOP G;  4O6X A;  1NGR A;  1WH4 A;  3LQQ A;  1C15 A;  2G7R A;  4D8O A;  4IZA B;  4A2Q A;  4M9S A;  1E41 A;  4O9L A;  1WMG A;  2D96 A;  3MOP K;  4M9Z A;  2M5V A;  4E9M A;  2OF5 H;  2N1F A;  2B1W A;  2YVI A;  4JQW A;  2HM2 Q;  2DO9 A;  4RHW A;  4O7Q A;  2MN4 A;  2P1H A;  2KM6 A;  2BBR A;  2DBD A;  3T6P A;  3CL3 A;  2YGS A;  4M9X A;  2L6A A;  1D2Z B;  4O9F A;  2LWD A;  4N1L A;  1CY5 A;  4I16 A;  2A9I A;  2OF5 A;  4IZ5 E;  2O71 A;  2NSN A;  1E3Y A;  3QF2 A;  1DGN A;  2N7Z A;  3KAT A;  2DBF A;  1D2Z A;  2IB1 A;  3MOP A;  2N80 A;  2L9M A;  3CRD A;  4RHW E;  3J63 A;  2LWE A;  4F44 A;  3LQR A;  2NZ7 A;  1YGO A;  2LS7 A;  4N1J A;  2KN6 A;  1Z6T A;  2N00 A;  4NQK A;  3J6J A;  4UZ0 A;  1WXP A;  4QOB A;  2A5Y B;  4DWN A;  1UCP A;  4JUP A;  4P4H A;  1A1W A;  2NAQ A;  2MS8 A;  1N3K A;  2YU0 A;  4F42 A;  2F1S A;  4FH0 A;  1A1Z A;  2GF5 A;  3YGS C;  2XV9 A;  2MPC A;  4A2W A;  4EWI A;  3EZQ A;  2YQF A;  2DBG A; 
#chains in the Genus database with same CATH homology
 4P4H I;  2N83 A;  4LWD A;  4ZBW A;  4N1K A;  3YGS P;  1ICH A;  2DBH A;  2MB9 A;  2VGQ A;  1CWW A;  1DDF A;  4IZ7 B;  2MS7 A;  2BBZ A;  2MJM A;  2N97 A;  3EZQ B;  1FAD A;  1PN5 A;  3MOP G;  4O6X A;  1NGR A;  1WH4 A;  3LQQ A;  1C15 A;  2G7R A;  4D8O A;  4IZA B;  4A2Q A;  4M9S A;  1E41 A;  4O9L A;  1WMG A;  2D96 A;  3MOP K;  4M9Z A;  2M5V A;  4E9M A;  2OF5 H;  2N1F A;  2B1W A;  2YVI A;  4JQW A;  2HM2 Q;  2DO9 A;  4RHW A;  4O7Q A;  2MN4 A;  2P1H A;  2KM6 A;  2BBR A;  2DBD A;  3T6P A;  3CL3 A;  2YGS A;  4M9X A;  2L6A A;  1D2Z B;  4O9F A;  2LWD A;  4N1L A;  1CY5 A;  4I16 A;  2A9I A;  2OF5 A;  4IZ5 E;  2O71 A;  2NSN A;  1E3Y A;  3QF2 A;  1DGN A;  2N7Z A;  3KAT A;  2DBF A;  1D2Z A;  2IB1 A;  3MOP A;  2N80 A;  2L9M A;  3CRD A;  4RHW E;  3J63 A;  2LWE A;  4F44 A;  3LQR A;  2NZ7 A;  1YGO A;  2LS7 A;  4N1J A;  2KN6 A;  1Z6T A;  2N00 A;  4NQK A;  3J6J A;  4UZ0 A;  1WXP A;  4QOB A;  2A5Y B;  4DWN A;  1UCP A;  4JUP A;  4P4H A;  1A1W A;  2NAQ A;  2MS8 A;  1N3K A;  2YU0 A;  4F42 A;  2F1S A;  4FH0 A;  1A1Z A;  2GF5 A;  3YGS C;  2XV9 A;  2MPC A;  4A2W A;  4EWI A;  3EZQ A;  2YQF A;  2DBG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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