1URBA

Alkaline phosphatase (n51mg)
Total Genus 163
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
163
Knots found
sequence length
446
structure length
446
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGNGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Kinetic and structural consequences of replacing the aspartate bridge by asparagine in the catalytic metal triad of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Alkaline phosphatase
total genus 163
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1996-02-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1urbA00
3A52A 5KXAA 1EW8A 2ANHA 3NKMA 3B5QA 1ED9A 2X98A 3Q3QA 3UNYA 3WAWA 4KJGA 1AJDA 1ED8A 4LRAA 5EGHA 1HJKA 2VQRA 1KH5A 4LR7A 5GOVA 1ANIA 4YR1A 1AJBA 3MK0A 3ED4A 3SZYA 1E1ZP 4GTZA 4ZG9A 3MK1A 1ELZA 1N2KA 5L0BA 3BDHA 3WAVA 1EJJA 4KJDA 2GSUA 2XRGA 2W5RA 1E2SP 4LR8A 5INHA 1EQJA 4UORA 4LREA 1ALHA 3UN5A 2D1GA 1AJAA 1B8JA 5LRMA 5AJ9A 1KH7A 2IFYA 3MK2A 1AJCA 4B56A 2QZUA 1ZEBA 2GA3A 3E2DA 3NKOA 1EW9A 2W5WA 4KM4A 2GSOA 5DLTA 4TN0A 4MHXA 4UOPA 4QAXA 3TWZA 1Y7AA 2W5XA 3WAXA 4N7TA 4LR2A 4UPKA 1ZEFA 4ZG6A 1P49A 4ZG7A 1KHNA 2IUCA 3WAYA 1KHKA 3UO0A 4UOOA 4LRCA 3DYCA 1ELYA 2W5SA 3NKNA 4LRDA 4UPHA 2W8DA 5K4PA 4CXKA 4NWJA 5EGEA 1O99A 5DLVA 3DPCA 3BDGB 5TJ3A 1URAA 2XR9A 2W5QA 5IJQA 3BDGA 3M8WA 2GSNA 5GRRA 1E33P 2ZKTA 4MY4A 5LRNA 3TG0A 2W5TA 2W8SA 2RH6A 4KAYA 1K7HA 1O98A 1HDHA 4KAVA 4CXUA 3BDFA 3T01A 3UN2A 3IGZB 3NKPA 3NVLA 4GTWA 1KH9A 3T02A 4LR9A 2IUCB 3LXQA 3KD8A 1ALJA 1Y6VA 4LQYA 4UPLA 4UPIA 3T00A 5C66A 5L0EA 3IDDA 1AUKA 1KH4A 1ZEDA 3CMRA 5DLWA 1E3CP 5HRTA 1KHLA 4FDIA 2GLQA 1EI6A 3UN3A 5LIAA 5LQQA 4LRFA 4MIVA 4GTYA 1URBA 3SZZA 1ELXA 3IGYB 4LRBA 1ALIA 1N2LA 3M8ZA 1SHQA 4CYSA 1SHNA 5L0KA 1FSUA 1ANJA 2W5VA 4NWXA 2G9YA 1ALKA 4CXSA 4GTXA 3M8YA 4CYRA 1KHJA 4FDJA 3WBHA 3M7VA 4ZGAA 1EW2A 1HQAA 3OT9A 3NKRA 3NKQA 3TX0A 5IJSA
chains in the Genus database with same CATH superfamily
3A52A 5KXAA 1EW8A 2ANHA 3NKMA 3B5QA 1ED9A 2X98A 3Q3QA 3UNYA 3WAWA 4KJGA 1AJDA 1ED8A 4LRAA 5EGHA 1HJKA 2VQRA 1KH5A 4LR7A 5GOVA 1ANIA 4YR1A 1AJBA 3MK0A 3ED4A 3SZYA 1E1ZP 4GTZA 4ZG9A 3MK1A 1ELZA 1N2KA 5L0BA 3BDHA 3WAVA 1EJJA 4KJDA 2GSUA 2XRGA 2W5RA 1E2SP 4LR8A 5INHA 1EQJA 4UORA 4LREA 1ALHA 3UN5A 2D1GA 1AJAA 1B8JA 5LRMA 5AJ9A 1KH7A 2IFYA 3MK2A 1AJCA 4B56A 2QZUA 1ZEBA 2GA3A 3E2DA 3NKOA 1EW9A 2W5WA 4KM4A 2GSOA 5DLTA 4TN0A 4MHXA 4UOPA 4QAXA 3TWZA 1Y7AA 2W5XA 3WAXA 4N7TA 4LR2A 4UPKA 1ZEFA 4ZG6A 1P49A 4ZG7A 1KHNA 2IUCA 3WAYA 1KHKA 3UO0A 4UOOA 4LRCA 3DYCA 1ELYA 2W5SA 3NKNA 4LRDA 4UPHA 2W8DA 5K4PA 4CXKA 4NWJA 5EGEA 1O99A 5DLVA 3DPCA 3BDGB 5TJ3A 1URAA 2XR9A 2W5QA 5IJQA 3BDGA 3M8WA 2GSNA 5GRRA 1E33P 2ZKTA 4MY4A 5LRNA 3TG0A 2W5TA 2W8SA 2RH6A 4KAYA 1K7HA 1O98A 1HDHA 4KAVA 4CXUA 3BDFA 3T01A 3UN2A 3IGZB 3NKPA 3NVLA 4GTWA 1KH9A 3T02A 4LR9A 2IUCB 3LXQA 3KD8A 1ALJA 1Y6VA 4LQYA 4UPLA 4UPIA 3T00A 5C66A 5L0EA 3IDDA 1AUKA 1KH4A 1ZEDA 3CMRA 5DLWA 1E3CP 5HRTA 1KHLA 4FDIA 2GLQA 1EI6A 3UN3A 5LIAA 5LQQA 4LRFA 4MIVA 4GTYA 1URBA 3SZZA 1ELXA 3IGYB 4LRBA 1ALIA 1N2LA 3M8ZA 1SHQA 4CYSA 1SHNA 5L0KA 1FSUA 1ANJA 2W5VA 4NWXA 2G9YA 1ALKA 4CXSA 4GTXA 3M8YA 4CYRA 1KHJA 4FDJA 3WBHA 3M7VA 4ZGAA 1EW2A 1HQAA 3OT9A 3NKRA 3NKQA 3TX0A 5IJSA
chains in the Genus database with same CATH topology
3A52A 5KXAA 1EW8A 2ANHA 3NKMA 3B5QA 1ED9A 2X98A 3Q3QA 3UNYA 3WAWA 4KJGA 1AJDA 1ED8A 4LRAA 5EGHA 1HJKA 2VQRA 1KH5A 4LR7A 5GOVA 1ANIA 4YR1A 1AJBA 3MK0A 3ED4A 3SZYA 1E1ZP 4GTZA 4ZG9A 3MK1A 1ELZA 1N2KA 5L0BA 3BDHA 3WAVA 1EJJA 4KJDA 2GSUA 2XRGA 2W5RA 1E2SP 4LR8A 5INHA 1EQJA 4UORA 4LREA 1ALHA 3UN5A 2D1GA 1AJAA 1B8JA 5LRMA 5AJ9A 1KH7A 2IFYA 3MK2A 1AJCA 4B56A 2QZUA 1ZEBA 2GA3A 3E2DA 3NKOA 1EW9A 2W5WA 4KM4A 2GSOA 5DLTA 4TN0A 4MHXA 4UOPA 4QAXA 3TWZA 1Y7AA 2W5XA 3WAXA 4N7TA 4LR2A 4UPKA 1ZEFA 4ZG6A 1P49A 4ZG7A 1KHNA 2IUCA 3WAYA 1KHKA 3UO0A 4UOOA 4LRCA 3DYCA 1ELYA 2W5SA 3NKNA 4LRDA 4UPHA 2W8DA 5K4PA 4CXKA 4NWJA 5EGEA 1O99A 5DLVA 3DPCA 3BDGB 5TJ3A 1URAA 2XR9A 2W5QA 5IJQA 3BDGA 3M8WA 2GSNA 5GRRA 1E33P 2ZKTA 4MY4A 5LRNA 3TG0A 2W5TA 2W8SA 2RH6A 4KAYA 1K7HA 1O98A 1HDHA 4KAVA 4CXUA 3BDFA 3T01A 3UN2A 3IGZB 3NKPA 3NVLA 4GTWA 1KH9A 3T02A 4LR9A 2IUCB 3LXQA 3KD8A 1ALJA 1Y6VA 4LQYA 4UPLA 4UPIA 3T00A 5C66A 5L0EA 3IDDA 1AUKA 1KH4A 1ZEDA 3CMRA 5DLWA 1E3CP 5HRTA 1KHLA 4FDIA 2GLQA 1EI6A 3UN3A 5LIAA 5LQQA 4LRFA 4MIVA 4GTYA 1URBA 3SZZA 1ELXA 3IGYB 4LRBA 1ALIA 1N2LA 3M8ZA 1SHQA 4CYSA 1SHNA 5L0KA 1FSUA 1ANJA 2W5VA 4NWXA 2G9YA 1ALKA 4CXSA 4GTXA 3M8YA 4CYRA 1KHJA 4FDJA 3WBHA 3M7VA 4ZGAA 1EW2A 1HQAA 3OT9A 3NKRA 3NKQA 3TX0A 5IJSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3A52 A;  5KXA A;  1EW8 A;  2ANH A;  3NKM A;  3B5Q A;  1ED9 A;  2X98 A;  3Q3Q A;  3UNY A;  3WAW A;  4KJG A;  1AJD A;  1ED8 A;  4LRA A;  5EGH A;  1HJK A;  2VQR A;  1KH5 A;  4LR7 A;  5GOV A;  1ANI A;  4YR1 A;  1AJB A;  3MK0 A;  3ED4 A;  3SZY A;  1E1Z P;  4GTZ A;  4ZG9 A;  3MK1 A;  1ELZ A;  1N2K A;  5L0B A;  3BDH A;  3WAV A;  1EJJ A;  4KJD A;  2GSU A;  2XRG A;  2W5R A;  1E2S P;  4LR8 A;  5INH A;  1EQJ A;  4UOR A;  4LRE A;  1ALH A;  3UN5 A;  2D1G A;  1AJA A;  1B8J A;  5LRM A;  5AJ9 A;  1KH7 A;  2IFY A;  3MK2 A;  1AJC A;  4B56 A;  2QZU A;  1ZEB A;  2GA3 A;  3E2D A;  3NKO A;  1EW9 A;  2W5W A;  4KM4 A;  2GSO A;  5DLT A;  4TN0 A;  4MHX A;  4UOP A;  4QAX A;  3TWZ A;  1Y7A A;  2W5X A;  3WAX A;  4N7T A;  4LR2 A;  4UPK A;  1ZEF A;  4ZG6 A;  1P49 A;  4ZG7 A;  1KHN A;  2IUC A;  3WAY A;  1KHK A;  3UO0 A;  4UOO A;  4LRC A;  3DYC A;  1ELY A;  2W5S A;  3NKN A;  4LRD A;  4UPH A;  2W8D A;  5K4P A;  4CXK A;  4NWJ A;  5EGE A;  1O99 A;  5DLV A;  3DPC A;  3BDG B;  5TJ3 A;  1URA A;  2XR9 A;  2W5Q A;  5IJQ A;  3BDG A;  3M8W A;  2GSN A;  5GRR A;  1E33 P;  2ZKT A;  4MY4 A;  5LRN A;  3TG0 A;  2W5T A;  2W8S A;  2RH6 A;  4KAY A;  1K7H A;  1O98 A;  1HDH A;  4KAV A;  4CXU A;  3BDF A;  3T01 A;  3UN2 A;  3IGZ B;  3NKP A;  3NVL A;  4GTW A;  1KH9 A;  3T02 A;  4LR9 A;  2IUC B;  3LXQ A;  3KD8 A;  1ALJ A;  1Y6V A;  4LQY A;  4UPL A;  4UPI A;  3T00 A;  5C66 A;  5L0E A;  3IDD A;  1AUK A;  1KH4 A;  1ZED A;  3CMR A;  5DLW A;  1E3C P;  5HRT A;  1KHL A;  4FDI A;  2GLQ A;  1EI6 A;  3UN3 A;  5LIA A;  5LQQ A;  4LRF A;  4MIV A;  4GTY A;  1URB A;  3SZZ A;  1ELX A;  3IGY B;  4LRB A;  1ALI A;  1N2L A;  3M8Z A;  1SHQ A;  4CYS A;  1SHN A;  5L0K A;  1FSU A;  1ANJ A;  2W5V A;  4NWX A;  2G9Y A;  1ALK A;  4CXS A;  4GTX A;  3M8Y A;  4CYR A;  1KHJ A;  4FDJ A;  3WBH A;  3M7V A;  4ZGA A;  1EW2 A;  1HQA A;  3OT9 A;  3NKR A;  3NKQ A;  3TX0 A;  5IJS A; 
#chains in the Genus database with same CATH topology
 3A52 A;  5KXA A;  1EW8 A;  2ANH A;  3NKM A;  3B5Q A;  1ED9 A;  2X98 A;  3Q3Q A;  3UNY A;  3WAW A;  4KJG A;  1AJD A;  1ED8 A;  4LRA A;  5EGH A;  1HJK A;  2VQR A;  1KH5 A;  4LR7 A;  5GOV A;  1ANI A;  4YR1 A;  1AJB A;  3MK0 A;  3ED4 A;  3SZY A;  1E1Z P;  4GTZ A;  4ZG9 A;  3MK1 A;  1ELZ A;  1N2K A;  5L0B A;  3BDH A;  3WAV A;  1EJJ A;  4KJD A;  2GSU A;  2XRG A;  2W5R A;  1E2S P;  4LR8 A;  5INH A;  1EQJ A;  4UOR A;  4LRE A;  1ALH A;  3UN5 A;  2D1G A;  1AJA A;  1B8J A;  5LRM A;  5AJ9 A;  1KH7 A;  2IFY A;  3MK2 A;  1AJC A;  4B56 A;  2QZU A;  1ZEB A;  2GA3 A;  3E2D A;  3NKO A;  1EW9 A;  2W5W A;  4KM4 A;  2GSO A;  5DLT A;  4TN0 A;  4MHX A;  4UOP A;  4QAX A;  3TWZ A;  1Y7A A;  2W5X A;  3WAX A;  4N7T A;  4LR2 A;  4UPK A;  1ZEF A;  4ZG6 A;  1P49 A;  4ZG7 A;  1KHN A;  2IUC A;  3WAY A;  1KHK A;  3UO0 A;  4UOO A;  4LRC A;  3DYC A;  1ELY A;  2W5S A;  3NKN A;  4LRD A;  4UPH A;  2W8D A;  5K4P A;  4CXK A;  4NWJ A;  5EGE A;  1O99 A;  5DLV A;  3DPC A;  3BDG B;  5TJ3 A;  1URA A;  2XR9 A;  2W5Q A;  5IJQ A;  3BDG A;  3M8W A;  2GSN A;  5GRR A;  1E33 P;  2ZKT A;  4MY4 A;  5LRN A;  3TG0 A;  2W5T A;  2W8S A;  2RH6 A;  4KAY A;  1K7H A;  1O98 A;  1HDH A;  4KAV A;  4CXU A;  3BDF A;  3T01 A;  3UN2 A;  3IGZ B;  3NKP A;  3NVL A;  4GTW A;  1KH9 A;  3T02 A;  4LR9 A;  2IUC B;  3LXQ A;  3KD8 A;  1ALJ A;  1Y6V A;  4LQY A;  4UPL A;  4UPI A;  3T00 A;  5C66 A;  5L0E A;  3IDD A;  1AUK A;  1KH4 A;  1ZED A;  3CMR A;  5DLW A;  1E3C P;  5HRT A;  1KHL A;  4FDI A;  2GLQ A;  1EI6 A;  3UN3 A;  5LIA A;  5LQQ A;  4LRF A;  4MIV A;  4GTY A;  1URB A;  3SZZ A;  1ELX A;  3IGY B;  4LRB A;  1ALI A;  1N2L A;  3M8Z A;  1SHQ A;  4CYS A;  1SHN A;  5L0K A;  1FSU A;  1ANJ A;  2W5V A;  4NWX A;  2G9Y A;  1ALK A;  4CXS A;  4GTX A;  3M8Y A;  4CYR A;  1KHJ A;  4FDJ A;  3WBH A;  3M7V A;  4ZGA A;  1EW2 A;  1HQA A;  3OT9 A;  3NKR A;  3NKQ A;  3TX0 A;  5IJS A; 
#chains in the Genus database with same CATH homology
 3A52 A;  5KXA A;  1EW8 A;  2ANH A;  3NKM A;  3B5Q A;  1ED9 A;  2X98 A;  3Q3Q A;  3UNY A;  3WAW A;  4KJG A;  1AJD A;  1ED8 A;  4LRA A;  5EGH A;  1HJK A;  2VQR A;  1KH5 A;  4LR7 A;  5GOV A;  1ANI A;  4YR1 A;  1AJB A;  3MK0 A;  3ED4 A;  3SZY A;  1E1Z P;  4GTZ A;  4ZG9 A;  3MK1 A;  1ELZ A;  1N2K A;  5L0B A;  3BDH A;  3WAV A;  1EJJ A;  4KJD A;  2GSU A;  2XRG A;  2W5R A;  1E2S P;  4LR8 A;  5INH A;  1EQJ A;  4UOR A;  4LRE A;  1ALH A;  3UN5 A;  2D1G A;  1AJA A;  1B8J A;  5LRM A;  5AJ9 A;  1KH7 A;  2IFY A;  3MK2 A;  1AJC A;  4B56 A;  2QZU A;  1ZEB A;  2GA3 A;  3E2D A;  3NKO A;  1EW9 A;  2W5W A;  4KM4 A;  2GSO A;  5DLT A;  4TN0 A;  4MHX A;  4UOP A;  4QAX A;  3TWZ A;  1Y7A A;  2W5X A;  3WAX A;  4N7T A;  4LR2 A;  4UPK A;  1ZEF A;  4ZG6 A;  1P49 A;  4ZG7 A;  1KHN A;  2IUC A;  3WAY A;  1KHK A;  3UO0 A;  4UOO A;  4LRC A;  3DYC A;  1ELY A;  2W5S A;  3NKN A;  4LRD A;  4UPH A;  2W8D A;  5K4P A;  4CXK A;  4NWJ A;  5EGE A;  1O99 A;  5DLV A;  3DPC A;  3BDG B;  5TJ3 A;  1URA A;  2XR9 A;  2W5Q A;  5IJQ A;  3BDG A;  3M8W A;  2GSN A;  5GRR A;  1E33 P;  2ZKT A;  4MY4 A;  5LRN A;  3TG0 A;  2W5T A;  2W8S A;  2RH6 A;  4KAY A;  1K7H A;  1O98 A;  1HDH A;  4KAV A;  4CXU A;  3BDF A;  3T01 A;  3UN2 A;  3IGZ B;  3NKP A;  3NVL A;  4GTW A;  1KH9 A;  3T02 A;  4LR9 A;  2IUC B;  3LXQ A;  3KD8 A;  1ALJ A;  1Y6V A;  4LQY A;  4UPL A;  4UPI A;  3T00 A;  5C66 A;  5L0E A;  3IDD A;  1AUK A;  1KH4 A;  1ZED A;  3CMR A;  5DLW A;  1E3C P;  5HRT A;  1KHL A;  4FDI A;  2GLQ A;  1EI6 A;  3UN3 A;  5LIA A;  5LQQ A;  4LRF A;  4MIV A;  4GTY A;  1URB A;  3SZZ A;  1ELX A;  3IGY B;  4LRB A;  1ALI A;  1N2L A;  3M8Z A;  1SHQ A;  4CYS A;  1SHN A;  5L0K A;  1FSU A;  1ANJ A;  2W5V A;  4NWX A;  2G9Y A;  1ALK A;  4CXS A;  4GTX A;  3M8Y A;  4CYR A;  1KHJ A;  4FDJ A;  3WBH A;  3M7V A;  4ZGA A;  1EW2 A;  1HQA A;  3OT9 A;  3NKR A;  3NKQ A;  3TX0 A;  5IJS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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