1URBA

Alkaline phosphatase (n51mg)
Total Genus 163
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
163
Knots found
sequence length
446
structure length
446
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGNGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Kinetic and structural consequences of replacing the aspartate bridge by asparagine in the catalytic metal triad of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Alkaline phosphatase
molecule keywords ALKALINE PHOSPHATASE
total genus 163
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1996-02-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1urbA00
2VQRA 1O99A 4TN0A 1KHLA 1ED8A 5HRTA 2W5RA 1EQJA 3Q3QA 4KAYA 3BDGA 1P49A 4UOOA 4UORA 1EJJA 2IUCB 2ZKTA 1ANIA 5TJ3A 1AJCA 1N2KA 1ZEDA 2W5WA 3OT9A 4LR8A 1ZEBA 4CYRA 5IJSA 5GRRA 4NWJA 5DLVA 1O98A 2W5SA 3M7VA 1E33P 1ED9A 1ALHA 3IGYB 4UPLA 5IJQA 4B56A 1ANJA 2RH6A 3BDHA 4FDJA 3T00A 1ALKA 4UOPA 3MK2A 4KAVA 5LRNA 2W5TA 3NVLA 4LRFA 3M8ZA 1B8JA 4YR1A 4GTWA 3TG0A 3E2DA 2W8DA 5INHA 1HQAA 1AJDA 3SZYA 3TX0A 5DLWA 4UPIA 1EI6A 4CXUA 1SHQA 2GA3A 3B5QA 3UN5A 4GTYA 4CYSA 3UNYA 5L0EA 3BDGB 3M8YA 1E2SP 3M8WA 4LRCA 2XRGA 5EGEA 5LQQA 4MIVA 3A52A 3UO0A 3LXQA 1KHKA 1ALIA 4MY4A 3NKMA 3DYCA 1E3CP 2X98A 3DPCA 1HJKA 1N2LA 4GTXA 2W5QA 4NWXA 1URAA 1KH7A 4KJDA 3UN2A 5DLTA 5K4PA 3IGZB 4ZG9A 5C66A 4KJGA 3T01A 4LR7A 4KM4A 1KHNA 4UPHA 4FDIA 4LRDA 4ZG6A 5KXAA 4LREA 4LR9A 1ELXA 2GSNA 2W8SA 1KH5A 3NKQA 4CXKA 1URBA 4LRBA 5EGHA 3NKRA 5AJ9A 2QZUA 1EW8A 3WAWA 1AUKA 1ELZA 1EW9A 2ANHA 2GSUA 5GOVA 1K7HA 3MK0A 3T02A 3WAYA 1ZEFA 2D1GA 2G9YA 1E1ZP 1ELYA 3NKOA 1SHNA 3TWZA 2W5VA 1FSUA 5LIAA 1AJAA 2XR9A 1AJBA 4UPKA 2W5XA 5LRMA 2IUCA 3WBHA 4CXSA 3WAVA 5L0KA 1KH9A 3ED4A 4LQYA 2GLQA 3NKPA 1EW2A 3CMRA 3IDDA 3SZZA 4LR2A 5L0BA 4GTZA 1HDHA 1KHJA 2GSOA 4LRAA 3MK1A 3NKNA 1KH4A 1Y6VA 3UN3A 4ZG7A 1Y7AA 1ALJA 2IFYA 4MHXA 4QAXA 3KD8A 4ZGAA 4N7TA 3BDFA 3WAXA
chains in the Genus database with same CATH superfamily
2VQRA 1O99A 4TN0A 1KHLA 1ED8A 5HRTA 2W5RA 1EQJA 3Q3QA 4KAYA 3BDGA 1P49A 4UOOA 4UORA 1EJJA 2IUCB 2ZKTA 1ANIA 5TJ3A 1AJCA 1N2KA 1ZEDA 2W5WA 3OT9A 4LR8A 1ZEBA 4CYRA 5IJSA 5GRRA 4NWJA 5DLVA 1O98A 2W5SA 3M7VA 1E33P 1ED9A 1ALHA 3IGYB 4UPLA 5IJQA 4B56A 1ANJA 2RH6A 3BDHA 4FDJA 3T00A 1ALKA 4UOPA 3MK2A 4KAVA 5LRNA 2W5TA 3NVLA 4LRFA 3M8ZA 1B8JA 4YR1A 4GTWA 3TG0A 3E2DA 2W8DA 5INHA 1HQAA 1AJDA 3SZYA 3TX0A 5DLWA 4UPIA 1EI6A 4CXUA 1SHQA 2GA3A 3B5QA 3UN5A 4GTYA 4CYSA 3UNYA 5L0EA 3BDGB 3M8YA 1E2SP 3M8WA 4LRCA 2XRGA 5EGEA 5LQQA 4MIVA 3A52A 3UO0A 3LXQA 1KHKA 1ALIA 4MY4A 3NKMA 3DYCA 1E3CP 2X98A 3DPCA 1HJKA 1N2LA 4GTXA 2W5QA 4NWXA 1URAA 1KH7A 4KJDA 3UN2A 5DLTA 5K4PA 3IGZB 4ZG9A 5C66A 4KJGA 3T01A 4LR7A 4KM4A 1KHNA 4UPHA 4FDIA 4LRDA 4ZG6A 5KXAA 4LREA 4LR9A 1ELXA 2GSNA 2W8SA 1KH5A 3NKQA 4CXKA 1URBA 4LRBA 5EGHA 3NKRA 5AJ9A 2QZUA 1EW8A 3WAWA 1AUKA 1ELZA 1EW9A 2ANHA 2GSUA 5GOVA 1K7HA 3MK0A 3T02A 3WAYA 1ZEFA 2D1GA 2G9YA 1E1ZP 1ELYA 3NKOA 1SHNA 3TWZA 2W5VA 1FSUA 5LIAA 1AJAA 2XR9A 1AJBA 4UPKA 2W5XA 5LRMA 2IUCA 3WBHA 4CXSA 3WAVA 5L0KA 1KH9A 3ED4A 4LQYA 2GLQA 3NKPA 1EW2A 3CMRA 3IDDA 3SZZA 4LR2A 5L0BA 4GTZA 1HDHA 1KHJA 2GSOA 4LRAA 3MK1A 3NKNA 1KH4A 1Y6VA 3UN3A 4ZG7A 1Y7AA 1ALJA 2IFYA 4MHXA 4QAXA 3KD8A 4ZGAA 4N7TA 3BDFA 3WAXA
chains in the Genus database with same CATH topology
2VQRA 1O99A 4TN0A 1KHLA 1ED8A 5HRTA 2W5RA 1EQJA 3Q3QA 4KAYA 3BDGA 1P49A 4UOOA 4UORA 1EJJA 2IUCB 2ZKTA 1ANIA 5TJ3A 1AJCA 1N2KA 1ZEDA 2W5WA 3OT9A 4LR8A 1ZEBA 4CYRA 5IJSA 5GRRA 4NWJA 5DLVA 1O98A 2W5SA 3M7VA 1E33P 1ED9A 1ALHA 3IGYB 4UPLA 5IJQA 4B56A 1ANJA 2RH6A 3BDHA 4FDJA 3T00A 1ALKA 4UOPA 3MK2A 4KAVA 5LRNA 2W5TA 3NVLA 4LRFA 3M8ZA 1B8JA 4YR1A 4GTWA 3TG0A 3E2DA 2W8DA 5INHA 1HQAA 1AJDA 3SZYA 3TX0A 5DLWA 4UPIA 1EI6A 4CXUA 1SHQA 2GA3A 3B5QA 3UN5A 4GTYA 4CYSA 3UNYA 5L0EA 3BDGB 3M8YA 1E2SP 3M8WA 4LRCA 2XRGA 5EGEA 5LQQA 4MIVA 3A52A 3UO0A 3LXQA 1KHKA 1ALIA 4MY4A 3NKMA 3DYCA 1E3CP 2X98A 3DPCA 1HJKA 1N2LA 4GTXA 2W5QA 4NWXA 1URAA 1KH7A 4KJDA 3UN2A 5DLTA 5K4PA 3IGZB 4ZG9A 5C66A 4KJGA 3T01A 4LR7A 4KM4A 1KHNA 4UPHA 4FDIA 4LRDA 4ZG6A 5KXAA 4LREA 4LR9A 1ELXA 2GSNA 2W8SA 1KH5A 3NKQA 4CXKA 1URBA 4LRBA 5EGHA 3NKRA 5AJ9A 2QZUA 1EW8A 3WAWA 1AUKA 1ELZA 1EW9A 2ANHA 2GSUA 5GOVA 1K7HA 3MK0A 3T02A 3WAYA 1ZEFA 2D1GA 2G9YA 1E1ZP 1ELYA 3NKOA 1SHNA 3TWZA 2W5VA 1FSUA 5LIAA 1AJAA 2XR9A 1AJBA 4UPKA 2W5XA 5LRMA 2IUCA 3WBHA 4CXSA 3WAVA 5L0KA 1KH9A 3ED4A 4LQYA 2GLQA 3NKPA 1EW2A 3CMRA 3IDDA 3SZZA 4LR2A 5L0BA 4GTZA 1HDHA 1KHJA 2GSOA 4LRAA 3MK1A 3NKNA 1KH4A 1Y6VA 3UN3A 4ZG7A 1Y7AA 1ALJA 2IFYA 4MHXA 4QAXA 3KD8A 4ZGAA 4N7TA 3BDFA 3WAXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VQR A;  1O99 A;  4TN0 A;  1KHL A;  1ED8 A;  5HRT A;  2W5R A;  1EQJ A;  3Q3Q A;  4KAY A;  3BDG A;  1P49 A;  4UOO A;  4UOR A;  1EJJ A;  2IUC B;  2ZKT A;  1ANI A;  5TJ3 A;  1AJC A;  1N2K A;  1ZED A;  2W5W A;  3OT9 A;  4LR8 A;  1ZEB A;  4CYR A;  5IJS A;  5GRR A;  4NWJ A;  5DLV A;  1O98 A;  2W5S A;  3M7V A;  1E33 P;  1ED9 A;  1ALH A;  3IGY B;  4UPL A;  5IJQ A;  4B56 A;  1ANJ A;  2RH6 A;  3BDH A;  4FDJ A;  3T00 A;  1ALK A;  4UOP A;  3MK2 A;  4KAV A;  5LRN A;  2W5T A;  3NVL A;  4LRF A;  3M8Z A;  1B8J A;  4YR1 A;  4GTW A;  3TG0 A;  3E2D A;  2W8D A;  5INH A;  1HQA A;  1AJD A;  3SZY A;  3TX0 A;  5DLW A;  4UPI A;  1EI6 A;  4CXU A;  1SHQ A;  2GA3 A;  3B5Q A;  3UN5 A;  4GTY A;  4CYS A;  3UNY A;  5L0E A;  3BDG B;  3M8Y A;  1E2S P;  3M8W A;  4LRC A;  2XRG A;  5EGE A;  5LQQ A;  4MIV A;  3A52 A;  3UO0 A;  3LXQ A;  1KHK A;  1ALI A;  4MY4 A;  3NKM A;  3DYC A;  1E3C P;  2X98 A;  3DPC A;  1HJK A;  1N2L A;  4GTX A;  2W5Q A;  4NWX A;  1URA A;  1KH7 A;  4KJD A;  3UN2 A;  5DLT A;  5K4P A;  3IGZ B;  4ZG9 A;  5C66 A;  4KJG A;  3T01 A;  4LR7 A;  4KM4 A;  1KHN A;  4UPH A;  4FDI A;  4LRD A;  4ZG6 A;  5KXA A;  4LRE A;  4LR9 A;  1ELX A;  2GSN A;  2W8S A;  1KH5 A;  3NKQ A;  4CXK A;  1URB A;  4LRB A;  5EGH A;  3NKR A;  5AJ9 A;  2QZU A;  1EW8 A;  3WAW A;  1AUK A;  1ELZ A;  1EW9 A;  2ANH A;  2GSU A;  5GOV A;  1K7H A;  3MK0 A;  3T02 A;  3WAY A;  1ZEF A;  2D1G A;  2G9Y A;  1E1Z P;  1ELY A;  3NKO A;  1SHN A;  3TWZ A;  2W5V A;  1FSU A;  5LIA A;  1AJA A;  2XR9 A;  1AJB A;  4UPK A;  2W5X A;  5LRM A;  2IUC A;  3WBH A;  4CXS A;  3WAV A;  5L0K A;  1KH9 A;  3ED4 A;  4LQY A;  2GLQ A;  3NKP A;  1EW2 A;  3CMR A;  3IDD A;  3SZZ A;  4LR2 A;  5L0B A;  4GTZ A;  1HDH A;  1KHJ A;  2GSO A;  4LRA A;  3MK1 A;  3NKN A;  1KH4 A;  1Y6V A;  3UN3 A;  4ZG7 A;  1Y7A A;  1ALJ A;  2IFY A;  4MHX A;  4QAX A;  3KD8 A;  4ZGA A;  4N7T A;  3BDF A;  3WAX A; 
#chains in the Genus database with same CATH topology
 2VQR A;  1O99 A;  4TN0 A;  1KHL A;  1ED8 A;  5HRT A;  2W5R A;  1EQJ A;  3Q3Q A;  4KAY A;  3BDG A;  1P49 A;  4UOO A;  4UOR A;  1EJJ A;  2IUC B;  2ZKT A;  1ANI A;  5TJ3 A;  1AJC A;  1N2K A;  1ZED A;  2W5W A;  3OT9 A;  4LR8 A;  1ZEB A;  4CYR A;  5IJS A;  5GRR A;  4NWJ A;  5DLV A;  1O98 A;  2W5S A;  3M7V A;  1E33 P;  1ED9 A;  1ALH A;  3IGY B;  4UPL A;  5IJQ A;  4B56 A;  1ANJ A;  2RH6 A;  3BDH A;  4FDJ A;  3T00 A;  1ALK A;  4UOP A;  3MK2 A;  4KAV A;  5LRN A;  2W5T A;  3NVL A;  4LRF A;  3M8Z A;  1B8J A;  4YR1 A;  4GTW A;  3TG0 A;  3E2D A;  2W8D A;  5INH A;  1HQA A;  1AJD A;  3SZY A;  3TX0 A;  5DLW A;  4UPI A;  1EI6 A;  4CXU A;  1SHQ A;  2GA3 A;  3B5Q A;  3UN5 A;  4GTY A;  4CYS A;  3UNY A;  5L0E A;  3BDG B;  3M8Y A;  1E2S P;  3M8W A;  4LRC A;  2XRG A;  5EGE A;  5LQQ A;  4MIV A;  3A52 A;  3UO0 A;  3LXQ A;  1KHK A;  1ALI A;  4MY4 A;  3NKM A;  3DYC A;  1E3C P;  2X98 A;  3DPC A;  1HJK A;  1N2L A;  4GTX A;  2W5Q A;  4NWX A;  1URA A;  1KH7 A;  4KJD A;  3UN2 A;  5DLT A;  5K4P A;  3IGZ B;  4ZG9 A;  5C66 A;  4KJG A;  3T01 A;  4LR7 A;  4KM4 A;  1KHN A;  4UPH A;  4FDI A;  4LRD A;  4ZG6 A;  5KXA A;  4LRE A;  4LR9 A;  1ELX A;  2GSN A;  2W8S A;  1KH5 A;  3NKQ A;  4CXK A;  1URB A;  4LRB A;  5EGH A;  3NKR A;  5AJ9 A;  2QZU A;  1EW8 A;  3WAW A;  1AUK A;  1ELZ A;  1EW9 A;  2ANH A;  2GSU A;  5GOV A;  1K7H A;  3MK0 A;  3T02 A;  3WAY A;  1ZEF A;  2D1G A;  2G9Y A;  1E1Z P;  1ELY A;  3NKO A;  1SHN A;  3TWZ A;  2W5V A;  1FSU A;  5LIA A;  1AJA A;  2XR9 A;  1AJB A;  4UPK A;  2W5X A;  5LRM A;  2IUC A;  3WBH A;  4CXS A;  3WAV A;  5L0K A;  1KH9 A;  3ED4 A;  4LQY A;  2GLQ A;  3NKP A;  1EW2 A;  3CMR A;  3IDD A;  3SZZ A;  4LR2 A;  5L0B A;  4GTZ A;  1HDH A;  1KHJ A;  2GSO A;  4LRA A;  3MK1 A;  3NKN A;  1KH4 A;  1Y6V A;  3UN3 A;  4ZG7 A;  1Y7A A;  1ALJ A;  2IFY A;  4MHX A;  4QAX A;  3KD8 A;  4ZGA A;  4N7T A;  3BDF A;  3WAX A; 
#chains in the Genus database with same CATH homology
 2VQR A;  1O99 A;  4TN0 A;  1KHL A;  1ED8 A;  5HRT A;  2W5R A;  1EQJ A;  3Q3Q A;  4KAY A;  3BDG A;  1P49 A;  4UOO A;  4UOR A;  1EJJ A;  2IUC B;  2ZKT A;  1ANI A;  5TJ3 A;  1AJC A;  1N2K A;  1ZED A;  2W5W A;  3OT9 A;  4LR8 A;  1ZEB A;  4CYR A;  5IJS A;  5GRR A;  4NWJ A;  5DLV A;  1O98 A;  2W5S A;  3M7V A;  1E33 P;  1ED9 A;  1ALH A;  3IGY B;  4UPL A;  5IJQ A;  4B56 A;  1ANJ A;  2RH6 A;  3BDH A;  4FDJ A;  3T00 A;  1ALK A;  4UOP A;  3MK2 A;  4KAV A;  5LRN A;  2W5T A;  3NVL A;  4LRF A;  3M8Z A;  1B8J A;  4YR1 A;  4GTW A;  3TG0 A;  3E2D A;  2W8D A;  5INH A;  1HQA A;  1AJD A;  3SZY A;  3TX0 A;  5DLW A;  4UPI A;  1EI6 A;  4CXU A;  1SHQ A;  2GA3 A;  3B5Q A;  3UN5 A;  4GTY A;  4CYS A;  3UNY A;  5L0E A;  3BDG B;  3M8Y A;  1E2S P;  3M8W A;  4LRC A;  2XRG A;  5EGE A;  5LQQ A;  4MIV A;  3A52 A;  3UO0 A;  3LXQ A;  1KHK A;  1ALI A;  4MY4 A;  3NKM A;  3DYC A;  1E3C P;  2X98 A;  3DPC A;  1HJK A;  1N2L A;  4GTX A;  2W5Q A;  4NWX A;  1URA A;  1KH7 A;  4KJD A;  3UN2 A;  5DLT A;  5K4P A;  3IGZ B;  4ZG9 A;  5C66 A;  4KJG A;  3T01 A;  4LR7 A;  4KM4 A;  1KHN A;  4UPH A;  4FDI A;  4LRD A;  4ZG6 A;  5KXA A;  4LRE A;  4LR9 A;  1ELX A;  2GSN A;  2W8S A;  1KH5 A;  3NKQ A;  4CXK A;  1URB A;  4LRB A;  5EGH A;  3NKR A;  5AJ9 A;  2QZU A;  1EW8 A;  3WAW A;  1AUK A;  1ELZ A;  1EW9 A;  2ANH A;  2GSU A;  5GOV A;  1K7H A;  3MK0 A;  3T02 A;  3WAY A;  1ZEF A;  2D1G A;  2G9Y A;  1E1Z P;  1ELY A;  3NKO A;  1SHN A;  3TWZ A;  2W5V A;  1FSU A;  5LIA A;  1AJA A;  2XR9 A;  1AJB A;  4UPK A;  2W5X A;  5LRM A;  2IUC A;  3WBH A;  4CXS A;  3WAV A;  5L0K A;  1KH9 A;  3ED4 A;  4LQY A;  2GLQ A;  3NKP A;  1EW2 A;  3CMR A;  3IDD A;  3SZZ A;  4LR2 A;  5L0B A;  4GTZ A;  1HDH A;  1KHJ A;  2GSO A;  4LRA A;  3MK1 A;  3NKN A;  1KH4 A;  1Y6V A;  3UN3 A;  4ZG7 A;  1Y7A A;  1ALJ A;  2IFY A;  4MHX A;  4QAX A;  3KD8 A;  4ZGA A;  4N7T A;  3BDF A;  3WAX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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