1VCUA

Structure of the human cytosolic sialidase neu2 in complex with the inhibitor dana
Total Genus 101
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
101
sequence length
377
structure length
370
Chain Sequence
MASLPVLQKESVFQSGAHAYRIPALLYLPGQQSLLAFAEQRASKKDEHAELIVLRRGDYDAPTHQVQWQAQEVVAQARLDGHRSMNPCPLYDAQTGTLFLFFIAIPGQVTEQQQLQTRANVTRLCQVTSTDHGRTWSSPRDLTDAAIGPAYREWSTFAVGPGHCLQLNDRARSLVVPAYAYRKLHPIQRPIPSAFCFLSHDHGRTWARGHFVAQDTLECQVAEVEQRVVTLNARSHLRARVQAQSTNDGLDFQESQLVKKLVEPPPQGCQGSVISFPSPRSPAQWLLYTHPTHSWQRADLGAYLNPRPPAPEAWSEPVLLAKGSCAYSDLQSMGTGPDGSPLFGCLYEANDYEEIVFLMFTLKQAFPAEY
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of the Human Cytosolic Sialidase Neu2: EVIDENCE FOR THE DYNAMIC NATURE OF SUBSTRATE RECOGNITION
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Sialidase 2
total genus 101
structure length 370
sequence length 377
chains with identical sequence B
ec nomenclature ec 3.2.1.18: Exo-alpha-sialidase.
pdb deposition date 2004-03-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF13088 BNR_2 BNR repeat-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.10 Mainly Beta 6 Propeller Neuraminidase Neuraminidase 1vcuA00
1F8CA 2HTQA 2ZB5A 3JU4A 4MWRA 2QWFA 3K38A 4D8SA 3TI3A 1IVFA 4FOQA 4HZWA 3INBA 4XJRA 7NN9A 4NN9A 2X9MA 3ALWA 4XE9A 2AEQA 4GZXA 4NC5A 4MWUA 1V0ZA 4B7JA 1DILA 1MS3A 2W5OA 6NN9A 2YA4A 4XJAA 1L7HA 1V2IA 3A71A 4WA4A 4MWXA 4X47A 4QN5A 4XIKA 4SLIA 2F0ZA 2F13A 2F26A 4K1JA 3K37A 4H53A 4KS2A 4K3YA 2AEPA 1Z4WA 4FPJA 2QWDA 4MWVA 4CPMA 4FPHA 1EUTA 2F11A 3OPZA 4XHBA 4GZPA 1USXA 2BATA 4FOVA 1EURA 3H73A 1NSDA 1W1XA 4K1IA 3SANA 2QWJA 2VW1A 2RKCA 4M4UA 4KS3A 4XMAA 1IVEA 1MWEA 3TI6A 5JYYA 1IVCA 4FP3A 4B7QA 4FPLA 4FPKA 1KITA 4XJ8A 1Z50A 2YA8A 1B9SA 2W38A 4MJUA 4CPZA 4YW4A 3O9KA 2HT8A 4HZYA 2BERA 3PJQA 5B2CA 4YZ2A 4XJZA 3NSSA 3CL0A 4HIZA 1INGA 1MS0A 4Q6KA 3SALA 2HT5A 2BZDA 1NMCA 1BJIA 1XOGA 4XJUA 4FOYA 1N1TA 5HUMA 4M4NA 1W0OA 1SLIA 4QN3A 1B9TA 4XIOA 3O9JA 4YW3A 2VSMA 1V3BA 2QWHA 2AH2A 2HTYA 3TIBA 1NNCA 1INYA 3GVKA 3BEQA 4CPLA 3D12A 2YA5A 1W8NA 4B7MA 1INVA 1F8DA 1NCCN 1W20A 4YW5A 4CPYA 4MZEA 4MC7A 5HUGA 1A14N 3B7EA 1Z4ZA 2CMLA 1N1SA 3A72A 3TI5A 4GB1A 1VCUA 1NCDN 1B9VA 4X4AA 2YDPA 4CPOA 3CL2A 2A75A 1V3CA 2F28A 2XZKA 4XOGA 2YA7A 4HZXA 2VK6A 3H72A 2JKBA 1E8TA 1MS4A 1MZ5A 4K1KA 4FQ4A 4DGRA 4XHXA 2VWDA 5M1ZA 2VSKA 2HTUA 2ZB6A 2F25A 4HZZA 4I00A 2FHRA 2BF6A 4YZ4A 4JF7A 4MWWA 2QWCA 1EUSA 4MX0A 4K1HA 1INFA 3T1EA 3CKZA 2W20A 4YZ1A 4FPFA 4XILA 4B7RA 2XZJA 1WCSA 1INWA 1W0PA 4MZAA 1S0JA 4FOWA 4WA5A 2C4AA 1WCQA 3CYEA 3K3AA 4GZTA 2VW0A 3ALXA 2W5NA 4WA3A 1USRA 5HUKA 4KS5A 5HX0A 4GDJA 4MWLA 2HU0A 3SILA 4MJVA 1A4GA 1IVGA 2HTWA 4GZQA 4GZSA 1V0EA 2HTVA 4FPOB 3H6JA 5NN9A 2HU4A 4FPCA 3TI8A 1L7GA 4QN4A 1INHA 4HZVA 4FZHA 1DIMA 1L7FA 3SLIA 4YZ5A 4QN6A 1A4QA 2SILA 1W8OA 1NN2A 4FPEA 2F24A 3TICA 1NMAN 1VCJA 3K39A 4XJWA 1IVBA 1N1YA 1E8VA 1V3DA 4M3MA 2QWKA 2QWAA 1MZ6A 2XZIA 4XJQA 1MS9A 1NSBA 2F12A 2VK7A 1E8UA 3TI4A 2HT7A 3K36A 1XOEA 4XMIA 2SIMA 1NNBA 4M4VA 5HUNA 2QWIA 2VK5A 4GEZA 1S0IA 1F8EA 4FP2A 1N1VA 1NCAN 4MWJA 2QWEA 4FJ6A 4MWYA 1NSCA 1V3EA 1F8BA 4GZWA 4FVKA 2YA6A 2B8HA 3D11A 4X49A 3W09A 4H52A 1Z4VA 4X6KA 4WEGA 1MS5A 1IVDA 4YW1A 5B2DA 1W21A 1NNAA 1V0FA 4GDIA 4CPNA 2F10A 4XJ9A 2AGSA 1INXA 1EUUA 2QWGA 4QNPA 1Z4XA 2VW2A 3TIAA 4XYXA 1NCBN 2C4LA 3B69A 3NN9A 3GVLA 4QN7A 2VVZA 1NMBN 1SNTA 4B7NA 5F9TA 4KS4A 1Z4YA 2YDTA 2QWBA 3GVJA 4MWQA 4BBWA 4FPYA 1MS8A 4UF7A 4YW2A 1MR5A 4YZ3A 4FPGA 4GJTA 4WEFA 1SO7A 4J9TA 2HTRA 2F29A 1MS1A 2SLIA 2XCYA 4GZOA 4NCSA 3H71A 2F27A 4KS1A 1SLLA
chains in the Genus database with same CATH superfamily
3Q6KA 1F8CA 3SOQA 1E1AA 2HTQA 1H6LA 2ZB5A 3WWAA 1N6FA 3IAXA 3JU4A 4HHOA 5FNSA 5FZJA 4MWRA 3LI4A 2QWFA 3K38A 4D8SA 5GX1A 3TI3A 1IVFA 4FOQA 4HZWA 3NO0A 4UOUA 3G4HA 3INBA 3ZGDA 4XJRA 7NN9A 4NN9A 2X9MA 3ALWA 4XE9A 3SOBB 2AEQA 4GZXA 4ASCA 5FWWA 4NC5A 2GVUA 4MWUA 1V0ZA 1CQ1A 4B7JA 1DILA 3LI3A 1MS3A 2W5OA 6NN9A 4IYGA 1X2RA 2YA4A 4XJAA 1L7HA 1V2IA 3A71A 2XN4A 4WA4A 4MWXA 4X47A 4QN5A 4XIKA 4PWZA 4SLIA 3P5BL 2F0ZA 2DG0A 2F13A 2F26A 4K1JA 3K37A 3I1CA 4H53A 4KS2A 4K3YA 3KYAA 2AEPA 1Z4WA 4FPJA 2QWDA 4MWVA 2IAPA 1V04A 4CPMA 4FPHA 1EUTA 3HLIA 2F11A 3OPZA 4IN4A 2ZZKA 4XHBA 1RWIA 4GZPA 4IFJA 1USXA 2BATA 3VNGA 4FOVA 1PJXA 1EURA 3H73A 2ZWAA 4D52B 1NSDA 1W1XA 2IAOA 4K1IA 3SANA 2QWJA 2VW1A 2RKCA 4M4UA 4KS3A 4XMAA 1IVEA 1MWEA 3TI6A 5JYYA 1IVCA 4FP3A 4B7QA 2IAUA 4FPLA 4FPKA 1KITA 4XJ8A 1Z50A 2YA8A 1B9SA 2W38A 4MJUA 4C1YA 4CPZA 1S1DA 4YW4A 4G3NA 3O9KA 2HT8A 4HZYA 2BERA 1QBIA 2ZW9A 2QE8A 3PJQA 3S2KA 4YZ2A 5B2CA 4XJZA 3NSSA 3CL0A 4HIZA 1N7DA 3S94A 1INGA 1MS0A 2FPCA 5GX4A 4Q6KA 3SALA 1POOA 2HT5A 2BZDA 1NMCA 1BJIA 1U6DX 1XOGA 1OFZA 4GN7A 2V91A 4FOYA 4XJUA 1N1TA 5HUMA 2GVXA 4M4NA 5F72C 1S18A 1W0OA 1SLIA 3FVZA 4QN3A 1B9TA 2WOZA 3A9GA 4XIOA 2IASA 3O9JA 4YW3A 5GTQA 2VSMA 1V3BA 2QWHA 2AH2A 2HTYA 3AMRA 3TIBA 1NNCA 2G8SA 1INYA 3BYCA 2DYHA 3GVKA 2GVVA 3BEQA 4CPLA 3D12A 2YA5A 1W8NA 4B7MA 1INVA 1F8DA 3LI5A 1NCCN 1W20A 3V65B 4YW5A 4CPYA 4MZEA 4MC7A 5HUGA 1A14N 4ZY3A 3G4EA 3B7EA 1Z4ZA 2CMLA 1N1SA 3A72A 3TI5A 3A9HA 1C5KA 4XMBA 4GB1A 1VCUA 4IFLX 1NCDN 1B9VA 4X4AA 2YDPA 5FNTA 4CPOA 2IAVA 3CL2A 2A75A 1K32A 1V3CA 2F28A 2XZKA 4XOGA 2OJHA 2YA7A 4HZXA 2IVZA 5D9BA 2VK6A 5EO7A 4L7CA 2H2UA 2W8BB 3H72A 2JKBA 1E8TA 1MS4A 1MZ5A 2GVWA 4K1KA 5FNQA 4GNBA 4FQ4A 4DGRA 4XHXA 2VWDA 5M1ZA 4AGTA 2VSKA 2HTUA 2ZB6A 2F25A 4HZZA 2IAXA 2FHRA 4I00A 3Q6PA 2BF6A 2POOA 4YZ4A 4JF7A 4MWWA 2IARA 4HW6A 2QWCA 1N6DA 3WN7A 1C9UA 1EUSA 4MX0A 4K1HA 1INFA 2IATA 4GN8A 1ZGKA 3S8ZA 2FP8A 3T1EA 3CKZA 2W20A 4R40A 4D52A 3FW0A 4YZ1A 4FPFA 4YY8A 4XILA 3HRPA 5FNUA 2H2NA 3ZGCA 2XZJA 4B7RA 1WCSA 4ZLRA 1INWA 5GX3A 1W0PA 4MZAA 1IUCA 2HQSA 1S0JA 4FOWA 4WA5A 4AGIA 4JMLA 4O5TA 3L6VA 1X2JA 2C4AA 1WCQA 3CYEA 1Q7FA 3K3AA 5FZNA 4GZTA 4AH4A 2VW0A 3ALXA 3S8VA 2W5NA 4WA3A 2VAQA 1N6EA 1USRA 5HUKA 3ADEA 4KS5A 5HX0A 4GN9A 3UC1A 4GDJA 4MWLA 2HU0A 3SILA 4MJVA 1IVGA 1A4GA 2HTWA 4GZQA 4GZSA 2FLUX 1V0EA 2HTVA 4FPOB 3H6JA 5D9CA 5NN9A 2HU4A 4IQKA 4AHAA 4FPCA 5D9DA 1L7GA 3TI8A 4IMBA 4QN4A 1INHA 4HZVA 4Q1UA 4FZHA 1DIMA 1L7FA 3SLIA 1CRZA 4YZ5A 4QN6A 2FP9A 1A4QA 2SILA 3DR2A 3V64C 3U0SA 1NN2A 4FPEA 5FNRA 2F24A 4CHBA 3TICA 4DG6A 4ZGCA 1NMAN 1VCJA 3E5ZA 3K39A 4HHQA 4XJWA 1IVBA 5CGJA 1N1YA 1E8VA 1V3DA 4M3MA 2QWKA 2QWAA 3WW9A 1IJQA 2VPJA 1MZ6A 2XZIA 1ZI0A 2IAWA 4XJQA 1MS9A 1NSBA 4O5SA 2F12A 2VK7A 1E8UA 4D4UA 4CH9A 3TI4A 2HT7A 3SRGA 3K36A 2DSOA 1XOEA 4XMIA 2SIMA 1NNBA 4M4VA 4CSDA 5HUNA 2QWIA 4L7DA 2VK5A 4GEZA 1S0IA 1F8EA 4FP2A 1N1VA 1NCAN 4MWJA 2QWEA 3V1SA 2W8BA 2ISMA 1CVMA 1NSCA 1SUUA 2FPBA 4FJ6A 4MWYA 4IFNX 5GX5A 5EO8A 1V3EA 1F8BA 5H47A 1IUBA 4GZWA 4FVKA 2YA6A 2B8HA 4GNAA 3D11A 3SREA 4X49A 4KS1A 3W09A 4H52A 1Z4VA 4X6KA 4WEGA 1MS5A 1IVDA 4YW1A 5B2DA 3SOVA 1W21A 1NNAA 1V0FA 4GDIA 4CPNA 2F10A 2Z32A 2DG1A 4XJ9A 2AGSA 1INXA 1EUUA 2QWGA 4QNPA 4C1YB 1Z4XA 2VW2A 4GNCA 4XYXA 3TIAA 1NCBN 2C4LA 3B69A 5GX2A 2P4OA 2GHSA 3NN9A 3GVLA 3VNHA 4QN7A 2VVZA 1NMBN 1RWLA 3KGGA 5EX7A 1SNTA 4N1BA 3WDZA 4B7NA 5F9TA 4KS4A 3DASA 1Z4YA 2YDTA 2QWBA 3GVJA 3O4PA 4A0PA 4MWQA 4BBWA 4L7BA 1NPEA 4FPYA 1MS8A 4UF7A 4YW2A 1MR5A 1QLGA 4YZ3A 4D52C 3TC9A 4FPGA 4GJTA 4WEFA 1SO7A 4J9TA 3AMSA 1WP5A 2HTRA 3II7A 1CRUA 2F29A 1MS1A 2SLIA 2XCYA 3Q6TA 3HLHA 2IAQA 4GZOA 4NCSA 3H71A 2F27A 1W8OA 1SLLA
chains in the Genus database with same CATH topology
1F8CA 2HTQA 2ZB5A 3JU4A 4MWRA 2QWFA 3K38A 4D8SA 3TI3A 1IVFA 4FOQA 4HZWA 3INBA 4XJRA 7NN9A 4NN9A 2X9MA 3ALWA 4XE9A 2AEQA 4GZXA 4NC5A 4MWUA 1V0ZA 4B7JA 1DILA 1MS3A 2W5OA 6NN9A 2YA4A 4XJAA 1L7HA 1V2IA 3A71A 4WA4A 4MWXA 4X47A 4QN5A 4XIKA 4SLIA 2F0ZA 2F13A 2F26A 4K1JA 3K37A 4H53A 4KS2A 4K3YA 2AEPA 1Z4WA 4FPJA 2QWDA 4MWVA 4CPMA 4FPHA 1EUTA 2F11A 3OPZA 4XHBA 4GZPA 1USXA 2BATA 4FOVA 1EURA 3H73A 1NSDA 1W1XA 4K1IA 3SANA 2QWJA 2VW1A 2RKCA 4M4UA 4KS3A 4XMAA 1IVEA 1MWEA 3TI6A 5JYYA 1IVCA 4FP3A 4B7QA 4FPLA 4FPKA 1KITA 4XJ8A 1Z50A 2YA8A 1B9SA 2W38A 4MJUA 4CPZA 1S1DA 4YW4A 3O9KA 2HT8A 4HZYA 2BERA 3PJQA 5B2CA 4YZ2A 4XJZA 3NSSA 3CL0A 4HIZA 1INGA 1MS0A 4Q6KA 3SALA 2HT5A 2BZDA 1NMCA 1BJIA 1XOGA 4XJUA 4FOYA 1N1TA 5HUMA 4M4NA 1S18A 1W0OA 1SLIA 4QN3A 1B9TA 4XIOA 3O9JA 4YW3A 2VSMA 1V3BA 2QWHA 2AH2A 2HTYA 3TIBA 1NNCA 1INYA 3GVKA 3BEQA 4CPLA 3D12A 2YA5A 1W8NA 4B7MA 1INVA 1F8DA 1NCCN 1W20A 4YW5A 4CPYA 4MZEA 4MC7A 5HUGA 1A14N 3B7EA 1Z4ZA 2CMLA 1N1SA 3A72A 3TI5A 4GB1A 1VCUA 1NCDN 1B9VA 4X4AA 2YDPA 4CPOA 3CL2A 2A75A 1V3CA 2F28A 2XZKA 4XOGA 2YA7A 4HZXA 2VK6A 2H2UA 3H72A 2JKBA 1E8TA 1MS4A 1MZ5A 4K1KA 4FQ4A 4DGRA 4XHXA 2VWDA 5M1ZA 2VSKA 2HTUA 2ZB6A 2F25A 4HZZA 4I00A 2FHRA 2BF6A 4YZ4A 4JF7A 4MWWA 2QWCA 1EUSA 4MX0A 4K1HA 1INFA 3T1EA 3CKZA 2W20A 4YZ1A 4FPFA 4XILA 2H2NA 4B7RA 2XZJA 1WCSA 1INWA 1W0PA 4MZAA 1S0JA 4FOWA 4WA5A 2C4AA 1WCQA 3CYEA 3K3AA 4GZTA 2VW0A 3ALXA 2W5NA 4WA3A 1USRA 5HUKA 4KS5A 5HX0A 4GDJA 4MWLA 2HU0A 3SILA 4MJVA 1A4GA 1IVGA 2HTWA 4GZQA 4GZSA 1V0EA 2HTVA 4FPOB 3H6JA 5NN9A 2HU4A 4FPCA 3TI8A 1L7GA 4QN4A 1INHA 4HZVA 4FZHA 1DIMA 1L7FA 3SLIA 4YZ5A 4QN6A 1A4QA 2SILA 1W8OA 1NN2A 4FPEA 2F24A 3TICA 1NMAN 1VCJA 3K39A 4XJWA 1IVBA 1N1YA 1E8VA 1V3DA 4M3MA 2QWKA 2QWAA 1MZ6A 2XZIA 4XJQA 1MS9A 1NSBA 2F12A 2VK7A 1E8UA 3TI4A 2HT7A 3K36A 1XOEA 4XMIA 2SIMA 1NNBA 4M4VA 5HUNA 2QWIA 2VK5A 4GEZA 1S0IA 1F8EA 4FP2A 1N1VA 1NCAN 4MWJA 2QWEA 4FJ6A 4MWYA 1NSCA 1V3EA 1F8BA 4GZWA 4FVKA 2YA6A 2B8HA 3D11A 4X49A 3W09A 4H52A 1Z4VA 4X6KA 4WEGA 1MS5A 1IVDA 4YW1A 5B2DA 1W21A 1NNAA 1V0FA 4GDIA 4CPNA 2F10A 4XJ9A 2AGSA 1INXA 1EUUA 2QWGA 4QNPA 1Z4XA 2VW2A 3TIAA 4XYXA 1NCBN 2C4LA 3B69A 3NN9A 3GVLA 4QN7A 2VVZA 1NMBN 1SNTA 4B7NA 5F9TA 4KS4A 1Z4YA 2YDTA 2QWBA 3GVJA 4MWQA 4BBWA 4FPYA 1MS8A 4UF7A 4YW2A 1MR5A 4YZ3A 4FPGA 4GJTA 4WEFA 1SO7A 4J9TA 2HTRA 2F29A 1MS1A 2SLIA 2XCYA 4GZOA 4NCSA 3H71A 2F27A 4KS1A 1SLLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1F8C A;  2HTQ A;  2ZB5 A;  3JU4 A;  4MWR A;  2QWF A;  3K38 A;  4D8S A;  3TI3 A;  1IVF A;  4FOQ A;  4HZW A;  3INB A;  4XJR A;  7NN9 A;  4NN9 A;  2X9M A;  3ALW A;  4XE9 A;  2AEQ A;  4GZX A;  4NC5 A;  4MWU A;  1V0Z A;  4B7J A;  1DIL A;  1MS3 A;  2W5O A;  6NN9 A;  2YA4 A;  4XJA A;  1L7H A;  1V2I A;  3A71 A;  4WA4 A;  4MWX A;  4X47 A;  4QN5 A;  4XIK A;  4SLI A;  2F0Z A;  2F13 A;  2F26 A;  4K1J A;  3K37 A;  4H53 A;  4KS2 A;  4K3Y A;  2AEP A;  1Z4W A;  4FPJ A;  2QWD A;  4MWV A;  4CPM A;  4FPH A;  1EUT A;  2F11 A;  3OPZ A;  4XHB A;  4GZP A;  1USX A;  2BAT A;  4FOV A;  1EUR A;  3H73 A;  1NSD A;  1W1X A;  4K1I A;  3SAN A;  2QWJ A;  2VW1 A;  2RKC A;  4M4U A;  4KS3 A;  4XMA A;  1IVE A;  1MWE A;  3TI6 A;  5JYY A;  1IVC A;  4FP3 A;  4B7Q A;  4FPL A;  4FPK A;  1KIT A;  4XJ8 A;  1Z50 A;  2YA8 A;  1B9S A;  2W38 A;  4MJU A;  4CPZ A;  4YW4 A;  3O9K A;  2HT8 A;  4HZY A;  2BER A;  3PJQ A;  5B2C A;  4YZ2 A;  4XJZ A;  3NSS A;  3CL0 A;  4HIZ A;  1ING A;  1MS0 A;  4Q6K A;  3SAL A;  2HT5 A;  2BZD A;  1NMC A;  1BJI A;  1XOG A;  4XJU A;  4FOY A;  1N1T A;  5HUM A;  4M4N A;  1W0O A;  1SLI A;  4QN3 A;  1B9T A;  4XIO A;  3O9J A;  4YW3 A;  2VSM A;  1V3B A;  2QWH A;  2AH2 A;  2HTY A;  3TIB A;  1NNC A;  1INY A;  3GVK A;  3BEQ A;  4CPL A;  3D12 A;  2YA5 A;  1W8N A;  4B7M A;  1INV A;  1F8D A;  1NCC N;  1W20 A;  4YW5 A;  4CPY A;  4MZE A;  4MC7 A;  5HUG A;  1A14 N;  3B7E A;  1Z4Z A;  2CML A;  1N1S A;  3A72 A;  3TI5 A;  4GB1 A;  1VCU A;  1NCD N;  1B9V A;  4X4A A;  2YDP A;  4CPO A;  3CL2 A;  2A75 A;  1V3C A;  2F28 A;  2XZK A;  4XOG A;  2YA7 A;  4HZX A;  2VK6 A;  3H72 A;  2JKB A;  1E8T A;  1MS4 A;  1MZ5 A;  4K1K A;  4FQ4 A;  4DGR A;  4XHX A;  2VWD A;  5M1Z A;  2VSK A;  2HTU A;  2ZB6 A;  2F25 A;  4HZZ A;  4I00 A;  2FHR A;  2BF6 A;  4YZ4 A;  4JF7 A;  4MWW A;  2QWC A;  1EUS A;  4MX0 A;  4K1H A;  1INF A;  3T1E A;  3CKZ A;  2W20 A;  4YZ1 A;  4FPF A;  4XIL A;  4B7R A;  2XZJ A;  1WCS A;  1INW A;  1W0P A;  4MZA A;  1S0J A;  4FOW A;  4WA5 A;  2C4A A;  1WCQ A;  3CYE A;  3K3A A;  4GZT A;  2VW0 A;  3ALX A;  2W5N A;  4WA3 A;  1USR A;  5HUK A;  4KS5 A;  5HX0 A;  4GDJ A;  4MWL A;  2HU0 A;  3SIL A;  4MJV A;  1A4G A;  1IVG A;  2HTW A;  4GZQ A;  4GZS A;  1V0E A;  2HTV A;  4FPO B;  3H6J A;  5NN9 A;  2HU4 A;  4FPC A;  3TI8 A;  1L7G A;  4QN4 A;  1INH A;  4HZV A;  4FZH A;  1DIM A;  1L7F A;  3SLI A;  4YZ5 A;  4QN6 A;  1A4Q A;  2SIL A;  1W8O A;  1NN2 A;  4FPE A;  2F24 A;  3TIC A;  1NMA N;  1VCJ A;  3K39 A;  4XJW A;  1IVB A;  1N1Y A;  1E8V A;  1V3D A;  4M3M A;  2QWK A;  2QWA A;  1MZ6 A;  2XZI A;  4XJQ A;  1MS9 A;  1NSB A;  2F12 A;  2VK7 A;  1E8U A;  3TI4 A;  2HT7 A;  3K36 A;  1XOE A;  4XMI A;  2SIM A;  1NNB A;  4M4V A;  5HUN A;  2QWI A;  2VK5 A;  4GEZ A;  1S0I A;  1F8E A;  4FP2 A;  1N1V A;  1NCA N;  4MWJ A;  2QWE A;  4FJ6 A;  4MWY A;  1NSC A;  1V3E A;  1F8B A;  4GZW A;  4FVK A;  2YA6 A;  2B8H A;  3D11 A;  4X49 A;  3W09 A;  4H52 A;  1Z4V A;  4X6K A;  4WEG A;  1MS5 A;  1IVD A;  4YW1 A;  5B2D A;  1W21 A;  1NNA A;  1V0F A;  4GDI A;  4CPN A;  2F10 A;  4XJ9 A;  2AGS A;  1INX A;  1EUU A;  2QWG A;  4QNP A;  1Z4X A;  2VW2 A;  3TIA A;  4XYX A;  1NCB N;  2C4L A;  3B69 A;  3NN9 A;  3GVL A;  4QN7 A;  2VVZ A;  1NMB N;  1SNT A;  4B7N A;  5F9T A;  4KS4 A;  1Z4Y A;  2YDT A;  2QWB A;  3GVJ A;  4MWQ A;  4BBW A;  4FPY A;  1MS8 A;  4UF7 A;  4YW2 A;  1MR5 A;  4YZ3 A;  4FPG A;  4GJT A;  4WEF A;  1SO7 A;  4J9T A;  2HTR A;  2F29 A;  1MS1 A;  2SLI A;  2XCY A;  4GZO A;  4NCS A;  3H71 A;  2F27 A;  4KS1 A;  1SLL A; 
#chains in the Genus database with same CATH topology
 3Q6K A;  1F8C A;  3SOQ A;  1E1A A;  2HTQ A;  1H6L A;  2ZB5 A;  3WWA A;  1N6F A;  3IAX A;  3JU4 A;  4HHO A;  5FNS A;  5FZJ A;  4MWR A;  3LI4 A;  2QWF A;  3K38 A;  4D8S A;  5GX1 A;  3TI3 A;  1IVF A;  4FOQ A;  4HZW A;  3NO0 A;  4UOU A;  3G4H A;  3INB A;  3ZGD A;  4XJR A;  7NN9 A;  4NN9 A;  2X9M A;  3ALW A;  4XE9 A;  3SOB B;  2AEQ A;  4GZX A;  4ASC A;  5FWW A;  4NC5 A;  2GVU A;  4MWU A;  1V0Z A;  1CQ1 A;  4B7J A;  1DIL A;  3LI3 A;  1MS3 A;  2W5O A;  6NN9 A;  4IYG A;  1X2R A;  2YA4 A;  4XJA A;  1L7H A;  1V2I A;  3A71 A;  2XN4 A;  4WA4 A;  4MWX A;  4X47 A;  4QN5 A;  4XIK A;  4PWZ A;  4SLI A;  3P5B L;  2F0Z A;  2DG0 A;  2F13 A;  2F26 A;  4K1J A;  3K37 A;  3I1C A;  4H53 A;  4KS2 A;  4K3Y A;  3KYA A;  2AEP A;  1Z4W A;  4FPJ A;  2QWD A;  4MWV A;  2IAP A;  1V04 A;  4CPM A;  4FPH A;  1EUT A;  3HLI A;  2F11 A;  3OPZ A;  4IN4 A;  2ZZK A;  4XHB A;  1RWI A;  4GZP A;  4IFJ A;  1USX A;  2BAT A;  3VNG A;  4FOV A;  1PJX A;  1EUR A;  3H73 A;  2ZWA A;  4D52 B;  1NSD A;  1W1X A;  2IAO A;  4K1I A;  3SAN A;  2QWJ A;  2VW1 A;  2RKC A;  4M4U A;  4KS3 A;  4XMA A;  1IVE A;  1MWE A;  3TI6 A;  5JYY A;  1IVC A;  4FP3 A;  4B7Q A;  2IAU A;  4FPL A;  4FPK A;  1KIT A;  4XJ8 A;  1Z50 A;  2YA8 A;  1B9S A;  2W38 A;  4MJU A;  4C1Y A;  4CPZ A;  1S1D A;  4YW4 A;  4G3N A;  3O9K A;  2HT8 A;  4HZY A;  2BER A;  1QBI A;  2ZW9 A;  2QE8 A;  3PJQ A;  3S2K A;  4YZ2 A;  5B2C A;  4XJZ A;  3NSS A;  3CL0 A;  4HIZ A;  1N7D A;  3S94 A;  1ING A;  1MS0 A;  2FPC A;  5GX4 A;  4Q6K A;  3SAL A;  1POO A;  2HT5 A;  2BZD A;  1NMC A;  1BJI A;  1U6D X;  1XOG A;  1OFZ A;  4GN7 A;  2V91 A;  4FOY A;  4XJU A;  1N1T A;  5HUM A;  2GVX A;  4M4N A;  5F72 C;  1S18 A;  1W0O A;  1SLI A;  3FVZ A;  4QN3 A;  1B9T A;  2WOZ A;  3A9G A;  4XIO A;  2IAS A;  3O9J A;  4YW3 A;  5GTQ A;  2VSM A;  1V3B A;  2QWH A;  2AH2 A;  2HTY A;  3AMR A;  3TIB A;  1NNC A;  2G8S A;  1INY A;  3BYC A;  2DYH A;  3GVK A;  2GVV A;  3BEQ A;  4CPL A;  3D12 A;  2YA5 A;  1W8N A;  4B7M A;  1INV A;  1F8D A;  3LI5 A;  1NCC N;  1W20 A;  3V65 B;  4YW5 A;  4CPY A;  4MZE A;  4MC7 A;  5HUG A;  1A14 N;  4ZY3 A;  3G4E A;  3B7E A;  1Z4Z A;  2CML A;  1N1S A;  3A72 A;  3TI5 A;  3A9H A;  1C5K A;  4XMB A;  4GB1 A;  1VCU A;  4IFL X;  1NCD N;  1B9V A;  4X4A A;  2YDP A;  5FNT A;  4CPO A;  2IAV A;  3CL2 A;  2A75 A;  1K32 A;  1V3C A;  2F28 A;  2XZK A;  4XOG A;  2OJH A;  2YA7 A;  4HZX A;  2IVZ A;  5D9B A;  2VK6 A;  5EO7 A;  4L7C A;  2H2U A;  2W8B B;  3H72 A;  2JKB A;  1E8T A;  1MS4 A;  1MZ5 A;  2GVW A;  4K1K A;  5FNQ A;  4GNB A;  4FQ4 A;  4DGR A;  4XHX A;  2VWD A;  5M1Z A;  4AGT A;  2VSK A;  2HTU A;  2ZB6 A;  2F25 A;  4HZZ A;  2IAX A;  2FHR A;  4I00 A;  3Q6P A;  2BF6 A;  2POO A;  4YZ4 A;  4JF7 A;  4MWW A;  2IAR A;  4HW6 A;  2QWC A;  1N6D A;  3WN7 A;  1C9U A;  1EUS A;  4MX0 A;  4K1H A;  1INF A;  2IAT A;  4GN8 A;  1ZGK A;  3S8Z A;  2FP8 A;  3T1E A;  3CKZ A;  2W20 A;  4R40 A;  4D52 A;  3FW0 A;  4YZ1 A;  4FPF A;  4YY8 A;  4XIL A;  3HRP A;  5FNU A;  2H2N A;  3ZGC A;  2XZJ A;  4B7R A;  1WCS A;  4ZLR A;  1INW A;  5GX3 A;  1W0P A;  4MZA A;  1IUC A;  2HQS A;  1S0J A;  4FOW A;  4WA5 A;  4AGI A;  4JML A;  4O5T A;  3L6V A;  1X2J A;  2C4A A;  1WCQ A;  3CYE A;  1Q7F A;  3K3A A;  5FZN A;  4GZT A;  4AH4 A;  2VW0 A;  3ALX A;  3S8V A;  2W5N A;  4WA3 A;  2VAQ A;  1N6E A;  1USR A;  5HUK A;  3ADE A;  4KS5 A;  5HX0 A;  4GN9 A;  3UC1 A;  4GDJ A;  4MWL A;  2HU0 A;  3SIL A;  4MJV A;  1IVG A;  1A4G A;  2HTW A;  4GZQ A;  4GZS A;  2FLU X;  1V0E A;  2HTV A;  4FPO B;  3H6J A;  5D9C A;  5NN9 A;  2HU4 A;  4IQK A;  4AHA A;  4FPC A;  5D9D A;  1L7G A;  3TI8 A;  4IMB A;  4QN4 A;  1INH A;  4HZV A;  4Q1U A;  4FZH A;  1DIM A;  1L7F A;  3SLI A;  1CRZ A;  4YZ5 A;  4QN6 A;  2FP9 A;  1A4Q A;  2SIL A;  3DR2 A;  3V64 C;  3U0S A;  1NN2 A;  4FPE A;  5FNR A;  2F24 A;  4CHB A;  3TIC A;  4DG6 A;  4ZGC A;  1NMA N;  1VCJ A;  3E5Z A;  3K39 A;  4HHQ A;  4XJW A;  1IVB A;  5CGJ A;  1N1Y A;  1E8V A;  1V3D A;  4M3M A;  2QWK A;  2QWA A;  3WW9 A;  1IJQ A;  2VPJ A;  1MZ6 A;  2XZI A;  1ZI0 A;  2IAW A;  4XJQ A;  1MS9 A;  1NSB A;  4O5S A;  2F12 A;  2VK7 A;  1E8U A;  4D4U A;  4CH9 A;  3TI4 A;  2HT7 A;  3SRG A;  3K36 A;  2DSO A;  1XOE A;  4XMI A;  2SIM A;  1NNB A;  4M4V A;  4CSD A;  5HUN A;  2QWI A;  4L7D A;  2VK5 A;  4GEZ A;  1S0I A;  1F8E A;  4FP2 A;  1N1V A;  1NCA N;  4MWJ A;  2QWE A;  3V1S A;  2W8B A;  2ISM A;  1CVM A;  1NSC A;  1SUU A;  2FPB A;  4FJ6 A;  4MWY A;  4IFN X;  5GX5 A;  5EO8 A;  1V3E A;  1F8B A;  5H47 A;  1IUB A;  4GZW A;  4FVK A;  2YA6 A;  2B8H A;  4GNA A;  3D11 A;  3SRE A;  4X49 A;  4KS1 A;  3W09 A;  4H52 A;  1Z4V A;  4X6K A;  4WEG A;  1MS5 A;  1IVD A;  4YW1 A;  5B2D A;  3SOV A;  1W21 A;  1NNA A;  1V0F A;  4GDI A;  4CPN A;  2F10 A;  2Z32 A;  2DG1 A;  4XJ9 A;  2AGS A;  1INX A;  1EUU A;  2QWG A;  4QNP A;  4C1Y B;  1Z4X A;  2VW2 A;  4GNC A;  4XYX A;  3TIA A;  1NCB N;  2C4L A;  3B69 A;  5GX2 A;  2P4O A;  2GHS A;  3NN9 A;  3GVL A;  3VNH A;  4QN7 A;  2VVZ A;  1NMB N;  1RWL A;  3KGG A;  5EX7 A;  1SNT A;  4N1B A;  3WDZ A;  4B7N A;  5F9T A;  4KS4 A;  3DAS A;  1Z4Y A;  2YDT A;  2QWB A;  3GVJ A;  3O4P A;  4A0P A;  4MWQ A;  4BBW A;  4L7B A;  1NPE A;  4FPY A;  1MS8 A;  4UF7 A;  4YW2 A;  1MR5 A;  1QLG A;  4YZ3 A;  4D52 C;  3TC9 A;  4FPG A;  4GJT A;  4WEF A;  1SO7 A;  4J9T A;  3AMS A;  1WP5 A;  2HTR A;  3II7 A;  1CRU A;  2F29 A;  1MS1 A;  2SLI A;  2XCY A;  3Q6T A;  3HLH A;  2IAQ A;  4GZO A;  4NCS A;  3H71 A;  2F27 A;  1W8O A;  1SLL A; 
#chains in the Genus database with same CATH homology
 1F8C A;  2HTQ A;  2ZB5 A;  3JU4 A;  4MWR A;  2QWF A;  3K38 A;  4D8S A;  3TI3 A;  1IVF A;  4FOQ A;  4HZW A;  3INB A;  4XJR A;  7NN9 A;  4NN9 A;  2X9M A;  3ALW A;  4XE9 A;  2AEQ A;  4GZX A;  4NC5 A;  4MWU A;  1V0Z A;  4B7J A;  1DIL A;  1MS3 A;  2W5O A;  6NN9 A;  2YA4 A;  4XJA A;  1L7H A;  1V2I A;  3A71 A;  4WA4 A;  4MWX A;  4X47 A;  4QN5 A;  4XIK A;  4SLI A;  2F0Z A;  2F13 A;  2F26 A;  4K1J A;  3K37 A;  4H53 A;  4KS2 A;  4K3Y A;  2AEP A;  1Z4W A;  4FPJ A;  2QWD A;  4MWV A;  4CPM A;  4FPH A;  1EUT A;  2F11 A;  3OPZ A;  4XHB A;  4GZP A;  1USX A;  2BAT A;  4FOV A;  1EUR A;  3H73 A;  1NSD A;  1W1X A;  4K1I A;  3SAN A;  2QWJ A;  2VW1 A;  2RKC A;  4M4U A;  4KS3 A;  4XMA A;  1IVE A;  1MWE A;  3TI6 A;  5JYY A;  1IVC A;  4FP3 A;  4B7Q A;  4FPL A;  4FPK A;  1KIT A;  4XJ8 A;  1Z50 A;  2YA8 A;  1B9S A;  2W38 A;  4MJU A;  4CPZ A;  1S1D A;  4YW4 A;  3O9K A;  2HT8 A;  4HZY A;  2BER A;  3PJQ A;  5B2C A;  4YZ2 A;  4XJZ A;  3NSS A;  3CL0 A;  4HIZ A;  1ING A;  1MS0 A;  4Q6K A;  3SAL A;  2HT5 A;  2BZD A;  1NMC A;  1BJI A;  1XOG A;  4XJU A;  4FOY A;  1N1T A;  5HUM A;  4M4N A;  1S18 A;  1W0O A;  1SLI A;  4QN3 A;  1B9T A;  4XIO A;  3O9J A;  4YW3 A;  2VSM A;  1V3B A;  2QWH A;  2AH2 A;  2HTY A;  3TIB A;  1NNC A;  1INY A;  3GVK A;  3BEQ A;  4CPL A;  3D12 A;  2YA5 A;  1W8N A;  4B7M A;  1INV A;  1F8D A;  1NCC N;  1W20 A;  4YW5 A;  4CPY A;  4MZE A;  4MC7 A;  5HUG A;  1A14 N;  3B7E A;  1Z4Z A;  2CML A;  1N1S A;  3A72 A;  3TI5 A;  4GB1 A;  1VCU A;  1NCD N;  1B9V A;  4X4A A;  2YDP A;  4CPO A;  3CL2 A;  2A75 A;  1V3C A;  2F28 A;  2XZK A;  4XOG A;  2YA7 A;  4HZX A;  2VK6 A;  2H2U A;  3H72 A;  2JKB A;  1E8T A;  1MS4 A;  1MZ5 A;  4K1K A;  4FQ4 A;  4DGR A;  4XHX A;  2VWD A;  5M1Z A;  2VSK A;  2HTU A;  2ZB6 A;  2F25 A;  4HZZ A;  4I00 A;  2FHR A;  2BF6 A;  4YZ4 A;  4JF7 A;  4MWW A;  2QWC A;  1EUS A;  4MX0 A;  4K1H A;  1INF A;  3T1E A;  3CKZ A;  2W20 A;  4YZ1 A;  4FPF A;  4XIL A;  2H2N A;  4B7R A;  2XZJ A;  1WCS A;  1INW A;  1W0P A;  4MZA A;  1S0J A;  4FOW A;  4WA5 A;  2C4A A;  1WCQ A;  3CYE A;  3K3A A;  4GZT A;  2VW0 A;  3ALX A;  2W5N A;  4WA3 A;  1USR A;  5HUK A;  4KS5 A;  5HX0 A;  4GDJ A;  4MWL A;  2HU0 A;  3SIL A;  4MJV A;  1A4G A;  1IVG A;  2HTW A;  4GZQ A;  4GZS A;  1V0E A;  2HTV A;  4FPO B;  3H6J A;  5NN9 A;  2HU4 A;  4FPC A;  3TI8 A;  1L7G A;  4QN4 A;  1INH A;  4HZV A;  4FZH A;  1DIM A;  1L7F A;  3SLI A;  4YZ5 A;  4QN6 A;  1A4Q A;  2SIL A;  1W8O A;  1NN2 A;  4FPE A;  2F24 A;  3TIC A;  1NMA N;  1VCJ A;  3K39 A;  4XJW A;  1IVB A;  1N1Y A;  1E8V A;  1V3D A;  4M3M A;  2QWK A;  2QWA A;  1MZ6 A;  2XZI A;  4XJQ A;  1MS9 A;  1NSB A;  2F12 A;  2VK7 A;  1E8U A;  3TI4 A;  2HT7 A;  3K36 A;  1XOE A;  4XMI A;  2SIM A;  1NNB A;  4M4V A;  5HUN A;  2QWI A;  2VK5 A;  4GEZ A;  1S0I A;  1F8E A;  4FP2 A;  1N1V A;  1NCA N;  4MWJ A;  2QWE A;  4FJ6 A;  4MWY A;  1NSC A;  1V3E A;  1F8B A;  4GZW A;  4FVK A;  2YA6 A;  2B8H A;  3D11 A;  4X49 A;  3W09 A;  4H52 A;  1Z4V A;  4X6K A;  4WEG A;  1MS5 A;  1IVD A;  4YW1 A;  5B2D A;  1W21 A;  1NNA A;  1V0F A;  4GDI A;  4CPN A;  2F10 A;  4XJ9 A;  2AGS A;  1INX A;  1EUU A;  2QWG A;  4QNP A;  1Z4X A;  2VW2 A;  3TIA A;  4XYX A;  1NCB N;  2C4L A;  3B69 A;  3NN9 A;  3GVL A;  4QN7 A;  2VVZ A;  1NMB N;  1SNT A;  4B7N A;  5F9T A;  4KS4 A;  1Z4Y A;  2YDT A;  2QWB A;  3GVJ A;  4MWQ A;  4BBW A;  4FPY A;  1MS8 A;  4UF7 A;  4YW2 A;  1MR5 A;  4YZ3 A;  4FPG A;  4GJT A;  4WEF A;  1SO7 A;  4J9T A;  2HTR A;  2F29 A;  1MS1 A;  2SLI A;  2XCY A;  4GZO A;  4NCS A;  3H71 A;  2F27 A;  4KS1 A;  1SLL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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