1W1KA

Structure of the octameric flavoenzyme vanillyl-alcohol oxidase: ile238thr mutant
Total Genus 182
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
182
sequence length
555
structure length
550
Chain Sequence
EFRPLTLPPKLSLSDFNEFIQDIIRIVGSENVEVISVDGSYMKPTHTHDPHHVMDQDYFLASAIVAPRNVADVQSIVGLANKFSFPLWPISIGRNSGYGGAAPRVSGSVVLDMGKNMNRVLEVNVEGAYCVVEPGVTYHDLHNYLEANNLRDKLWLDVPDLGGGSVLGNAVERGVGYTPYGDHWMMHSGMEVVLANGELLRTGMGALPDPKRPETMGLKPEDQPWSKTAHLFPYGFGPYIDGLFSQSNMGIVTKIGIWLMPNPRGYQSYLITLPKDGDLKQAVDIIRPLRLGMALQNVPTIRHILLDAAVLGDKRSYSSRTEPLSDEELDKIAKQLNLGRWNFYGALYGPEPIRRVLWETIKDAFSAIPGVKFYFPEDTPENSVLRVRDKTMQGIPTYDELKWIDWLPNGAHLFFSPIAKVSGEDAMMQYAVTKKRCQEAGLDFIGTFTVGMREMHHIVCIVFNKKDLIQKRKVQWLMRTLIDDCAANGWGEYRTHLAFMDQIMETYNWNNSSFLRFNEVLKNAVDPNGIIAPGKSGVWPSQYSHVTWKL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords VANILLYL-ALCOHOL OXIDASE
publication title Laboratory-Evolved Vanillyl-Alcohol Oxidase Produces Natural Vanillin
pubmed doi rcsb
source organism Penicillium simplicissimum
molecule tags Oxidoreductase
total genus 182
structure length 550
sequence length 555
chains with identical sequence B
ec nomenclature ec 1.1.3.38: Vanillyl-alcohol oxidase.
pdb deposition date 2004-06-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01565 FAD_binding_4 FAD binding domain
A PF02913 FAD-oxidase_C FAD linked oxidases, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.45.10 Mainly Alpha Orthogonal Bundle Vanillyl-alcohol Oxidase; Chain A, domain 4 Vanillyl-alcohol Oxidase; Chain A, domain 4 1w1kA04
3.30.43.10 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2 1w1kA01
3.30.465.10 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 1w1kA02
3.40.462.10 Alpha Beta 3-Layer(aba) Sandwich Vanillyl-alcohol Oxidase; Chain A, domain 3 FAD-linked oxidases, C-terminal domain 1w1kA03
4PYTA 5AE2A 3NVVB 3C0PA 5HMRA 4BC7A 1N60C 4PVEA 3D2HA 2Q85A 1E8FA 2PLSA 2VFSA 2GQUA 4BC9A 3NS1B 1W1LA 1AHVA 5FXFA 1FO4A 3NRZB 3HRDC 2Q4WA 3TSHA 2PLIA 3NVYB 1N63C 1N62C 1T3QC 3D2JA 2MBRA 3B9JB 2O3GA 1E8GA 2YVSA 4PZFA 4EC3A 2W55A 5FXPA 4JAYA 3FW8A 3NVZB 1AHUA 2BVFA 1AHZA 1W1JA 3BW7A 2I0KA 1QLUA 3AN1A 2R8DA 1DZNA 1I19A 4O95A 2QPMA 2R2ZA 1WVEA 1FFVC 5G5HB 2EXRA 1N5WC 3W8WA 1VDVA 3S1FA 5FXEA 2P3HA 3PM9A 1W1RA 3EUB3 2W54A 1VAOA 2NQWA 5FXDA 5AE3A 1JRPA 1WYGA 1F0XA 3S1CA 1WVFA 1FIQB 3VTEA 3LAEA 2VAOA 3SR6B 1SB3B 2BVGA 2P13A 1N61C 3JS8A 3D2DA 2W3SA 3W8ZA 2E3TA 3S1DA 2VFRA 1W1MA 3I99A 3NVWB 1HSKA 1FFUC 2AXRA 5ADZA 4PVJA 2RK5A 4PVKA 4ML8A 3LLBA 3GSYA 4DNSA 3KJMA 3ETRB 3DEDA 4PWCA 1DIQA 3AMZA 1DIIA 4PWBA 4PVHA 5HQXA 2VFUA 1W1SA 2W3RA 3S1EA 1N5XA 4JB1A 1E0YA 5D79A 1ZR6A 2VFVA 3FW7A 5HHZA 1JROA 3FW9A 4MLAA 4OALA 4XLOA 3FWAA 2OAIA 4HG0A 4BBYA 3W8XA 4ZOHB 2VFTA 1W1KA 2GQTA 1UXYA 1E8HA 2BVHA 5G5GB 3TX1A 5AE1A 1MBBA 4BCAA 2QKNA 1W1OA 4UD8A 1QLTA 1W1QA 3TSJA 1RM6B 3DQ0A 3AM9A 2P4PA 1MBTA 1ZXIC 1V97A
chains in the Genus database with same CATH superfamily
4PYTA 5AE2A 3NVVB 3C0PA 5HMRA 4BC7A 2Y4GA 2Y3RA 1N60C 4PVEA 3D2HA 2Q85A 1E8FA 2PLSA 2VFSA 2GQUA 4BC9A 3RJAA 3NS1B 1W1LA 1AHVA 5FXFA 1FO4A 3NRZB 3HRDC 2Q4WA 3NVYB 3TSHA 2PLIA 1N63C 1N62C 1T3QC 3D2JA 2MBRA 3B9JB 2O3GA 1E8GA 2YVSA 4PZFA 4EC3A 5AWVA 2Y3SA 2W55A 3RJ8A 5FXPA 4JAYA 3FW8A 3NVZB 1AHUA 2WDWA 2BVFA 5I1WA 1AHZA 1W1JA 3BW7A 2I0KA 5K8EA 1QLUA 3AN1A 2R8DA 1DZNA 1I19A 4O95A 2QPMA 2R2ZA 1WVEA 1FFVC 5G5HB 2EXRA 1N5WC 3W8WA 1VDVA 3S1FA 5FXEA 2P3HA 3PM9A 3POPA 1W1RA 3EUB3 2W54A 1VAOA 2NQWA 5FXDA 3EJEB 5AE3A 1JRPA 3EJBB 1WYGA 1F0XA 3S1CA 1WVFA 1FIQB 3VTEA 3LAEA 2VAOA 3SR6B 1SB3B 2BVGA 2P13A 1N61C 3JS8A 5L6FA 3D2DA 2W3SA 2UUUA 3W8ZA 2E3TA 3S1DA 2VFRA 1W1MA 3I99A 3NVWB 1HSKA 1FFUC 2AXRA 5ADZA 5L6GA 4PVJA 2RK5A 2UUVA 4PVKA 4ML8A 3LLBA 3HSUA 2Y08A 3GSYA 4DNSA 3KJMA 3ETRB 3DEDA 2IPIA 4PWCA 1DIQA 3AMZA 1DIIA 4PWBA 4PVHA 5HQXA 2VFUA 1W1SA 2W3RA 3S1EA 1N5XA 5I1VA 4JB1A 1E0YA 5D79A 1ZR6A 2VFVA 3FW7A 5HHZA 1JROA 3FW9A 4MLAA 4OALA 4XLOA 3FWAA 2OAIA 4HG0A 4BBYA 3W8XA 4ZOHB 2VFTA 1W1KA 2GQTA 1UXYA 1E8HA 2BVHA 5G5GB 3TX1A 5AE1A 1MBBA 4BCAA 2QKNA 1W1OA 4UD8A 3EJDB 1QLTA 3PQBA 1W1QA 3TSJA 1RM6B 3DQ0A 3AM9A 2P4PA 1MBTA 1ZXIC 1V97A
chains in the Genus database with same CATH topology
4PYTA 5AE2A 3NVVB 3C0PA 5HMRA 4BC7A 2Y4GA 2Y3RA 1N60C 4PVEA 3D2HA 2Q85A 1E8FA 2PLSA 2VFSA 2GQUA 4BC9A 3RJAA 3NS1B 1W1LA 1AHVA 5FXFA 1FO4A 3NRZB 3HRDC 2Q4WA 3TSHA 2PLIA 3NVYB 1N63C 1N62C 1T3QC 3D2JA 2MBRA 3B9JB 2O3GA 1E8GA 2YVSA 4PZFA 4EC3A 5AWVA 2Y3SA 2W55A 3RJ8A 5FXPA 4JAYA 3FW8A 3NVZB 1AHUA 2WDWA 2BVFA 5I1WA 1AHZA 1W1JA 3BW7A 2I0KA 5K8EA 1QLUA 3AN1A 2R8DA 1DZNA 1I19A 4O95A 2QPMA 2R2ZA 1WVEA 1FFVC 5G5HB 2EXRA 1N5WC 3W8WA 1VDVA 3S1FA 5FXEA 2P3HA 3PM9A 3POPA 1W1RA 3EUB3 2W54A 1VAOA 2NQWA 5FXDA 5AE3A 1JRPA 1WYGA 1F0XA 3S1CA 1WVFA 1FIQB 3VTEA 3LAEA 2VAOA 3SR6B 1SB3B 2BVGA 2P13A 1N61C 3JS8A 5L6FA 3D2DA 2W3SA 2UUUA 3W8ZA 2E3TA 3S1DA 2VFRA 1W1MA 3I99A 3NVWB 1HSKA 1FFUC 2AXRA 5ADZA 5L6GA 4PVJA 2RK5A 2UUVA 4PVKA 4ML8A 3LLBA 3HSUA 2Y08A 3GSYA 4DNSA 3KJMA 3ETRB 3DEDA 2IPIA 4PWCA 1DIQA 3AMZA 1DIIA 4PWBA 4PVHA 5HQXA 2VFUA 1W1SA 2W3RA 3S1EA 1N5XA 5I1VA 4JB1A 1E0YA 5D79A 1ZR6A 2VFVA 3FW7A 5HHZA 1JROA 3FW9A 4MLAA 4OALA 4XLOA 3FWAA 2OAIA 4HG0A 4BBYA 3W8XA 4ZOHB 2VFTA 1W1KA 2GQTA 1UXYA 1E8HA 2BVHA 5G5GB 3TX1A 5AE1A 1MBBA 4BCAA 2QKNA 1W1OA 4UD8A 1QLTA 3PQBA 1W1QA 3TSJA 1RM6B 3DQ0A 3AM9A 2P4PA 1MBTA 1ZXIC 1V97A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4PYT A;  5AE2 A;  3NVV B;  3C0P A;  5HMR A;  4BC7 A;  1N60 C;  4PVE A;  3D2H A;  2Q85 A;  1E8F A;  2PLS A;  2VFS A;  2GQU A;  4BC9 A;  3NS1 B;  1W1L A;  1AHV A;  5FXF A;  1FO4 A;  3NRZ B;  3HRD C;  2Q4W A;  3TSH A;  2PLI A;  3NVY B;  1N63 C;  1N62 C;  1T3Q C;  3D2J A;  2MBR A;  3B9J B;  2O3G A;  1E8G A;  2YVS A;  4PZF A;  4EC3 A;  2W55 A;  5FXP A;  4JAY A;  3FW8 A;  3NVZ B;  1AHU A;  2BVF A;  1AHZ A;  1W1J A;  3BW7 A;  2I0K A;  1QLU A;  3AN1 A;  2R8D A;  1DZN A;  1I19 A;  4O95 A;  2QPM A;  2R2Z A;  1WVE A;  1FFV C;  5G5H B;  2EXR A;  1N5W C;  3W8W A;  1VDV A;  3S1F A;  5FXE A;  2P3H A;  3PM9 A;  1W1R A;  3EUB 3;  2W54 A;  1VAO A;  2NQW A;  5FXD A;  5AE3 A;  1JRP A;  1WYG A;  1F0X A;  3S1C A;  1WVF A;  1FIQ B;  3VTE A;  3LAE A;  2VAO A;  3SR6 B;  1SB3 B;  2BVG A;  2P13 A;  1N61 C;  3JS8 A;  3D2D A;  2W3S A;  3W8Z A;  2E3T A;  3S1D A;  2VFR A;  1W1M A;  3I99 A;  3NVW B;  1HSK A;  1FFU C;  2AXR A;  5ADZ A;  4PVJ A;  2RK5 A;  4PVK A;  4ML8 A;  3LLB A;  3GSY A;  4DNS A;  3KJM A;  3ETR B;  3DED A;  4PWC A;  1DIQ A;  3AMZ A;  1DII A;  4PWB A;  4PVH A;  5HQX A;  2VFU A;  1W1S A;  2W3R A;  3S1E A;  1N5X A;  4JB1 A;  1E0Y A;  5D79 A;  1ZR6 A;  2VFV A;  3FW7 A;  5HHZ A;  1JRO A;  3FW9 A;  4MLA A;  4OAL A;  4XLO A;  3FWA A;  2OAI A;  4HG0 A;  4BBY A;  3W8X A;  4ZOH B;  2VFT A;  1W1K A;  2GQT A;  1UXY A;  1E8H A;  2BVH A;  5G5G B;  3TX1 A;  5AE1 A;  1MBB A;  4BCA A;  2QKN A;  1W1O A;  4UD8 A;  1QLT A;  1W1Q A;  3TSJ A;  1RM6 B;  3DQ0 A;  3AM9 A;  2P4P A;  1MBT A;  1ZXI C;  1V97 A; 
#chains in the Genus database with same CATH topology
 4PYT A;  5AE2 A;  3NVV B;  3C0P A;  5HMR A;  4BC7 A;  2Y4G A;  2Y3R A;  1N60 C;  4PVE A;  3D2H A;  2Q85 A;  1E8F A;  2PLS A;  2VFS A;  2GQU A;  4BC9 A;  3RJA A;  3NS1 B;  1W1L A;  1AHV A;  5FXF A;  1FO4 A;  3NRZ B;  3HRD C;  2Q4W A;  3NVY B;  3TSH A;  2PLI A;  1N63 C;  1N62 C;  1T3Q C;  3D2J A;  2MBR A;  3B9J B;  2O3G A;  1E8G A;  2YVS A;  4PZF A;  4EC3 A;  5AWV A;  2Y3S A;  2W55 A;  3RJ8 A;  5FXP A;  4JAY A;  3FW8 A;  3NVZ B;  1AHU A;  2WDW A;  2BVF A;  5I1W A;  1AHZ A;  1W1J A;  3BW7 A;  2I0K A;  5K8E A;  1QLU A;  3AN1 A;  2R8D A;  1DZN A;  1I19 A;  4O95 A;  2QPM A;  2R2Z A;  1WVE A;  1FFV C;  5G5H B;  2EXR A;  1N5W C;  3W8W A;  1VDV A;  3S1F A;  5FXE A;  2P3H A;  3PM9 A;  3POP A;  1W1R A;  3EUB 3;  2W54 A;  1VAO A;  2NQW A;  5FXD A;  3EJE B;  5AE3 A;  1JRP A;  3EJB B;  1WYG A;  1F0X A;  3S1C A;  1WVF A;  1FIQ B;  3VTE A;  3LAE A;  2VAO A;  3SR6 B;  1SB3 B;  2BVG A;  2P13 A;  1N61 C;  3JS8 A;  5L6F A;  3D2D A;  2W3S A;  2UUU A;  3W8Z A;  2E3T A;  3S1D A;  2VFR A;  1W1M A;  3I99 A;  3NVW B;  1HSK A;  1FFU C;  2AXR A;  5ADZ A;  5L6G A;  4PVJ A;  2RK5 A;  2UUV A;  4PVK A;  4ML8 A;  3LLB A;  3HSU A;  2Y08 A;  3GSY A;  4DNS A;  3KJM A;  3ETR B;  3DED A;  2IPI A;  4PWC A;  1DIQ A;  3AMZ A;  1DII A;  4PWB A;  4PVH A;  5HQX A;  2VFU A;  1W1S A;  2W3R A;  3S1E A;  1N5X A;  5I1V A;  4JB1 A;  1E0Y A;  5D79 A;  1ZR6 A;  2VFV A;  3FW7 A;  5HHZ A;  1JRO A;  3FW9 A;  4MLA A;  4OAL A;  4XLO A;  3FWA A;  2OAI A;  4HG0 A;  4BBY A;  3W8X A;  4ZOH B;  2VFT A;  1W1K A;  2GQT A;  1UXY A;  1E8H A;  2BVH A;  5G5G B;  3TX1 A;  5AE1 A;  1MBB A;  4BCA A;  2QKN A;  1W1O A;  4UD8 A;  3EJD B;  1QLT A;  3PQB A;  1W1Q A;  3TSJ A;  1RM6 B;  3DQ0 A;  3AM9 A;  2P4P A;  1MBT A;  1ZXI C;  1V97 A; 
#chains in the Genus database with same CATH homology
 4PYT A;  5AE2 A;  3NVV B;  3C0P A;  5HMR A;  4BC7 A;  2Y4G A;  2Y3R A;  1N60 C;  4PVE A;  3D2H A;  2Q85 A;  1E8F A;  2PLS A;  2VFS A;  2GQU A;  4BC9 A;  3RJA A;  3NS1 B;  1W1L A;  1AHV A;  5FXF A;  1FO4 A;  3NRZ B;  3HRD C;  2Q4W A;  3TSH A;  2PLI A;  3NVY B;  1N63 C;  1N62 C;  1T3Q C;  3D2J A;  2MBR A;  3B9J B;  2O3G A;  1E8G A;  2YVS A;  4PZF A;  4EC3 A;  5AWV A;  2Y3S A;  2W55 A;  3RJ8 A;  5FXP A;  4JAY A;  3FW8 A;  3NVZ B;  1AHU A;  2WDW A;  2BVF A;  5I1W A;  1AHZ A;  1W1J A;  3BW7 A;  2I0K A;  5K8E A;  1QLU A;  3AN1 A;  2R8D A;  1DZN A;  1I19 A;  4O95 A;  2QPM A;  2R2Z A;  1WVE A;  1FFV C;  5G5H B;  2EXR A;  1N5W C;  3W8W A;  1VDV A;  3S1F A;  5FXE A;  2P3H A;  3PM9 A;  3POP A;  1W1R A;  3EUB 3;  2W54 A;  1VAO A;  2NQW A;  5FXD A;  5AE3 A;  1JRP A;  1WYG A;  1F0X A;  3S1C A;  1WVF A;  1FIQ B;  3VTE A;  3LAE A;  2VAO A;  3SR6 B;  1SB3 B;  2BVG A;  2P13 A;  1N61 C;  3JS8 A;  5L6F A;  3D2D A;  2W3S A;  2UUU A;  3W8Z A;  2E3T A;  3S1D A;  2VFR A;  1W1M A;  3I99 A;  3NVW B;  1HSK A;  1FFU C;  2AXR A;  5ADZ A;  5L6G A;  4PVJ A;  2RK5 A;  2UUV A;  4PVK A;  4ML8 A;  3LLB A;  3HSU A;  2Y08 A;  3GSY A;  4DNS A;  3KJM A;  3ETR B;  3DED A;  2IPI A;  4PWC A;  1DIQ A;  3AMZ A;  1DII A;  4PWB A;  4PVH A;  5HQX A;  2VFU A;  1W1S A;  2W3R A;  3S1E A;  1N5X A;  5I1V A;  4JB1 A;  1E0Y A;  5D79 A;  1ZR6 A;  2VFV A;  3FW7 A;  5HHZ A;  1JRO A;  3FW9 A;  4MLA A;  4OAL A;  4XLO A;  3FWA A;  2OAI A;  4HG0 A;  4BBY A;  3W8X A;  4ZOH B;  2VFT A;  1W1K A;  2GQT A;  1UXY A;  1E8H A;  2BVH A;  5G5G B;  3TX1 A;  5AE1 A;  1MBB A;  4BCA A;  2QKN A;  1W1O A;  4UD8 A;  1QLT A;  3PQB A;  1W1Q A;  3TSJ A;  1RM6 B;  3DQ0 A;  3AM9 A;  2P4P A;  1MBT A;  1ZXI C;  1V97 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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