1W1KA

Structure of the octameric flavoenzyme vanillyl-alcohol oxidase: ile238thr mutant
Total Genus 182
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
182
sequence length
555
structure length
550
Chain Sequence
EFRPLTLPPKLSLSDFNEFIQDIIRIVGSENVEVISVDGSYMKPTHTHDPHHVMDQDYFLASAIVAPRNVADVQSIVGLANKFSFPLWPISIGRNSGYGGAAPRVSGSVVLDMGKNMNRVLEVNVEGAYCVVEPGVTYHDLHNYLEANNLRDKLWLDVPDLGGGSVLGNAVERGVGYTPYGDHWMMHSGMEVVLANGELLRTGMGALPDPKRPETMGLKPEDQPWSKTAHLFPYGFGPYIDGLFSQSNMGIVTKIGIWLMPNPRGYQSYLITLPKDGDLKQAVDIIRPLRLGMALQNVPTIRHILLDAAVLGDKRSYSSRTEPLSDEELDKIAKQLNLGRWNFYGALYGPEPIRRVLWETIKDAFSAIPGVKFYFPEDTPENSVLRVRDKTMQGIPTYDELKWIDWLPNGAHLFFSPIAKVSGEDAMMQYAVTKKRCQEAGLDFIGTFTVGMREMHHIVCIVFNKKDLIQKRKVQWLMRTLIDDCAANGWGEYRTHLAFMDQIMETYNWNNSSFLRFNEVLKNAVDPNGIIAPGKSGVWPSQYSHVTWKL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Laboratory-Evolved Vanillyl-Alcohol Oxidase Produces Natural Vanillin
pubmed doi rcsb
source organism Penicillium simplicissimum
molecule tags Oxidoreductase
molecule keywords VANILLYL-ALCOHOL OXIDASE
total genus 182
structure length 550
sequence length 555
chains with identical sequence B
ec nomenclature ec 1.1.3.38: Vanillyl-alcohol oxidase.
pdb deposition date 2004-06-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01565 FAD_binding_4 FAD binding domain
A PF02913 FAD-oxidase_C FAD linked oxidases, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.45.10 Mainly Alpha Orthogonal Bundle Vanillyl-alcohol Oxidase; Chain A, domain 4 Vanillyl-alcohol Oxidase; Chain A, domain 4 1w1kA04
3.30.43.10 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2 1w1kA01
3.30.465.10 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 1w1kA02
3.40.462.10 Alpha Beta 3-Layer(aba) Sandwich Vanillyl-alcohol Oxidase; Chain A, domain 3 FAD-linked oxidases, C-terminal domain 1w1kA03
5D79A 3S1EA 1W1SA 3D2DA 1DZNA 1N61C 1FFVC 2BVGA 3EUB3 5HHZA 2PLIA 3S1DA 1UXYA 2E3TA 4BC7A 3DQ0A 4PVKA 4EC3A 1W1LA 3TX1A 4DNSA 2W3SA 3PM9A 1QLUA 4ML8A 1W1JA 4BCAA 1W1RA 3FW8A 5AE3A 4JB1A 2W54A 3W8XA 2BVHA 1RM6B 3FW9A 4PVHA 4BBYA 5AE1A 4O95A 1T3QC 1E8GA 1N62C 4PYTA 3S1CA 4JAYA 3AM9A 2Q4WA 3LLBA 2YVSA 4PVJA 3KJMA 2VFTA 3C0PA 3TSHA 2P3HA 3ETRB 1N5XA 4HG0A 1E0YA 1F0XA 1AHZA 3DEDA 2VFUA 5G5GB 2Q85A 1N5WC 1SB3B 5ADZA 4UD8A 2AXRA 3NVYB 1DIIA 5G5HB 2VAOA 1VDVA 3FW7A 2R2ZA 5FXEA 1MBTA 3GSYA 1WVEA 1HSKA 2VFRA 2QKNA 1W1MA 1N63C 2VFSA 1FO4A 1AHUA 2I0KA 4PWBA 3W8ZA 3AMZA 3JS8A 3NRZB 4MLAA 5FXPA 2W3RA 5FXDA 5HMRA 1W1OA 2O3GA 2QPMA 4ZOHB 3VTEA 3D2JA 2MBRA 1ZR6A 2GQUA 3NS1B 1WVFA 1QLTA 1W1QA 2P13A 3LAEA 3S1FA 1VAOA 4OALA 3FWAA 3NVVB 1JROA 4XLOA 2P4PA 2NQWA 5AE2A 1JRPA 5HQXA 3D2HA 3I99A 1FIQB 2EXRA 1MBBA 3B9JB 4PZFA 2RK5A 2PLSA 5FXFA 1V97A 2W55A 4PWCA 4BC9A 1E8FA 3SR6B 3AN1A 2BVFA 2R8DA 1N60C 2GQTA 2VFVA 3BW7A 4PVEA 3W8WA 1AHVA 3TSJA 3NVWB 1E8HA 1WYGA 3NVZB 2OAIA 3HRDC 1ZXIC 1W1KA 1DIQA 1FFUC 1I19A
chains in the Genus database with same CATH superfamily
2UUUA 5D79A 3S1EA 1W1SA 3D2DA 1DZNA 2UUVA 1N61C 1FFVC 2BVGA 3EUB3 5HHZA 3EJBB 2PLIA 3S1DA 1UXYA 2E3TA 4BC7A 3DQ0A 4PVKA 4EC3A 5L6FA 1W1LA 5K8EA 3TX1A 4DNSA 2W3SA 3PM9A 1QLUA 2Y3RA 4ML8A 1W1JA 4BCAA 1W1RA 3FW8A 5AE3A 4JB1A 2W54A 3W8XA 2WDWA 2BVHA 1RM6B 3FW9A 4PVHA 4BBYA 5AE1A 4O95A 1T3QC 3HSUA 1E8GA 1N62C 3POPA 4PYTA 3S1CA 4JAYA 3AM9A 2Q4WA 3LLBA 2YVSA 4PVJA 3KJMA 2VFTA 3C0PA 3TSHA 2P3HA 3ETRB 1N5XA 4HG0A 1E0YA 1F0XA 1AHZA 3DEDA 3RJ8A 2VFUA 5G5GB 2Q85A 1N5WC 1SB3B 5ADZA 4UD8A 2AXRA 3NVYB 1DIIA 5G5HB 2VAOA 1VDVA 3FW7A 2R2ZA 5I1VA 5FXEA 1MBTA 3GSYA 1WVEA 1HSKA 2VFRA 2QKNA 1W1MA 3RJAA 5I1WA 1N63C 5AWVA 2VFSA 1FO4A 1AHUA 2I0KA 4PWBA 3W8ZA 3AMZA 3JS8A 3NRZB 4MLAA 5FXPA 2W3RA 5FXDA 5HMRA 2Y08A 1W1OA 2O3GA 2QPMA 4ZOHB 3VTEA 3D2JA 2MBRA 1ZR6A 2GQUA 3NS1B 3PQBA 1WVFA 1QLTA 2Y3SA 1W1QA 2P13A 3LAEA 3S1FA 2IPIA 1VAOA 4OALA 3FWAA 3NVVB 1JROA 4XLOA 2P4PA 5L6GA 3EJEB 2NQWA 5AE2A 1JRPA 5HQXA 2Y4GA 3D2HA 3I99A 1FIQB 2EXRA 1MBBA 3B9JB 4PZFA 2RK5A 2PLSA 5FXFA 1V97A 2W55A 4PWCA 3EJDB 4BC9A 1E8FA 3SR6B 3AN1A 2BVFA 2R8DA 1N60C 2GQTA 2VFVA 3BW7A 4PVEA 3W8WA 1AHVA 3TSJA 3NVWB 1E8HA 1WYGA 3NVZB 2OAIA 3HRDC 1ZXIC 1W1KA 1DIQA 1FFUC 1I19A
chains in the Genus database with same CATH topology
2UUUA 5D79A 3S1EA 1W1SA 3D2DA 1DZNA 2UUVA 1N61C 1FFVC 2BVGA 3EUB3 5HHZA 2PLIA 3S1DA 1UXYA 2E3TA 4BC7A 3DQ0A 4PVKA 4EC3A 5L6FA 1W1LA 5K8EA 3TX1A 4DNSA 2W3SA 3PM9A 1QLUA 2Y3RA 4ML8A 1W1JA 4BCAA 1W1RA 3FW8A 5AE3A 4JB1A 2W54A 3W8XA 2WDWA 2BVHA 1RM6B 3FW9A 4PVHA 4BBYA 5AE1A 4O95A 1T3QC 3HSUA 1E8GA 1N62C 3POPA 4PYTA 3S1CA 4JAYA 3AM9A 2Q4WA 3LLBA 2YVSA 4PVJA 3KJMA 2VFTA 3C0PA 3TSHA 2P3HA 3ETRB 1N5XA 4HG0A 1E0YA 1F0XA 1AHZA 3DEDA 3RJ8A 2VFUA 5G5GB 2Q85A 1N5WC 1SB3B 5ADZA 4UD8A 2AXRA 3NVYB 1DIIA 5G5HB 2VAOA 1VDVA 3FW7A 2R2ZA 5I1VA 5FXEA 1MBTA 3GSYA 1WVEA 1HSKA 2VFRA 2QKNA 1W1MA 3RJAA 5I1WA 1N63C 5AWVA 2VFSA 1FO4A 1AHUA 2I0KA 4PWBA 3W8ZA 3AMZA 3JS8A 3NRZB 4MLAA 5FXPA 2W3RA 5FXDA 5HMRA 2Y08A 1W1OA 2O3GA 2QPMA 4ZOHB 3VTEA 3D2JA 2MBRA 1ZR6A 2GQUA 3NS1B 3PQBA 1WVFA 1QLTA 2Y3SA 1W1QA 2P13A 3LAEA 3S1FA 2IPIA 1VAOA 4OALA 3FWAA 3NVVB 1JROA 4XLOA 2P4PA 5L6GA 2NQWA 5AE2A 1JRPA 5HQXA 2Y4GA 3D2HA 3I99A 1FIQB 2EXRA 1MBBA 3B9JB 4PZFA 2RK5A 2PLSA 5FXFA 1V97A 2W55A 4PWCA 4BC9A 1E8FA 3SR6B 3AN1A 2BVFA 2R8DA 1N60C 2GQTA 2VFVA 3BW7A 4PVEA 3W8WA 1AHVA 3TSJA 3NVWB 1E8HA 1WYGA 3NVZB 2OAIA 3HRDC 1ZXIC 1W1KA 1DIQA 1FFUC 1I19A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5D79 A;  3S1E A;  1W1S A;  3D2D A;  1DZN A;  1N61 C;  1FFV C;  2BVG A;  3EUB 3;  5HHZ A;  2PLI A;  3S1D A;  1UXY A;  2E3T A;  4BC7 A;  3DQ0 A;  4PVK A;  4EC3 A;  1W1L A;  3TX1 A;  4DNS A;  2W3S A;  3PM9 A;  1QLU A;  4ML8 A;  1W1J A;  4BCA A;  1W1R A;  3FW8 A;  5AE3 A;  4JB1 A;  2W54 A;  3W8X A;  2BVH A;  1RM6 B;  3FW9 A;  4PVH A;  4BBY A;  5AE1 A;  4O95 A;  1T3Q C;  1E8G A;  1N62 C;  4PYT A;  3S1C A;  4JAY A;  3AM9 A;  2Q4W A;  3LLB A;  2YVS A;  4PVJ A;  3KJM A;  2VFT A;  3C0P A;  3TSH A;  2P3H A;  3ETR B;  1N5X A;  4HG0 A;  1E0Y A;  1F0X A;  1AHZ A;  3DED A;  2VFU A;  5G5G B;  2Q85 A;  1N5W C;  1SB3 B;  5ADZ A;  4UD8 A;  2AXR A;  3NVY B;  1DII A;  5G5H B;  2VAO A;  1VDV A;  3FW7 A;  2R2Z A;  5FXE A;  1MBT A;  3GSY A;  1WVE A;  1HSK A;  2VFR A;  2QKN A;  1W1M A;  1N63 C;  2VFS A;  1FO4 A;  1AHU A;  2I0K A;  4PWB A;  3W8Z A;  3AMZ A;  3JS8 A;  3NRZ B;  4MLA A;  5FXP A;  2W3R A;  5FXD A;  5HMR A;  1W1O A;  2O3G A;  2QPM A;  4ZOH B;  3VTE A;  3D2J A;  2MBR A;  1ZR6 A;  2GQU A;  3NS1 B;  1WVF A;  1QLT A;  1W1Q A;  2P13 A;  3LAE A;  3S1F A;  1VAO A;  4OAL A;  3FWA A;  3NVV B;  1JRO A;  4XLO A;  2P4P A;  2NQW A;  5AE2 A;  1JRP A;  5HQX A;  3D2H A;  3I99 A;  1FIQ B;  2EXR A;  1MBB A;  3B9J B;  4PZF A;  2RK5 A;  2PLS A;  5FXF A;  1V97 A;  2W55 A;  4PWC A;  4BC9 A;  1E8F A;  3SR6 B;  3AN1 A;  2BVF A;  2R8D A;  1N60 C;  2GQT A;  2VFV A;  3BW7 A;  4PVE A;  3W8W A;  1AHV A;  3TSJ A;  3NVW B;  1E8H A;  1WYG A;  3NVZ B;  2OAI A;  3HRD C;  1ZXI C;  1W1K A;  1DIQ A;  1FFU C;  1I19 A; 
#chains in the Genus database with same CATH topology
 2UUU A;  5D79 A;  3S1E A;  1W1S A;  3D2D A;  1DZN A;  2UUV A;  1N61 C;  1FFV C;  2BVG A;  3EUB 3;  5HHZ A;  3EJB B;  2PLI A;  3S1D A;  1UXY A;  2E3T A;  4BC7 A;  3DQ0 A;  4PVK A;  4EC3 A;  5L6F A;  1W1L A;  5K8E A;  3TX1 A;  4DNS A;  2W3S A;  3PM9 A;  1QLU A;  2Y3R A;  4ML8 A;  1W1J A;  4BCA A;  1W1R A;  3FW8 A;  5AE3 A;  4JB1 A;  2W54 A;  3W8X A;  2WDW A;  2BVH A;  1RM6 B;  3FW9 A;  4PVH A;  4BBY A;  5AE1 A;  4O95 A;  1T3Q C;  3HSU A;  1E8G A;  1N62 C;  3POP A;  4PYT A;  3S1C A;  4JAY A;  3AM9 A;  2Q4W A;  3LLB A;  2YVS A;  4PVJ A;  3KJM A;  2VFT A;  3C0P A;  3TSH A;  2P3H A;  3ETR B;  1N5X A;  4HG0 A;  1E0Y A;  1F0X A;  1AHZ A;  3DED A;  3RJ8 A;  2VFU A;  5G5G B;  2Q85 A;  1N5W C;  1SB3 B;  5ADZ A;  4UD8 A;  2AXR A;  3NVY B;  1DII A;  5G5H B;  2VAO A;  1VDV A;  3FW7 A;  2R2Z A;  5I1V A;  5FXE A;  1MBT A;  3GSY A;  1WVE A;  1HSK A;  2VFR A;  2QKN A;  1W1M A;  3RJA A;  5I1W A;  1N63 C;  5AWV A;  2VFS A;  1FO4 A;  1AHU A;  2I0K A;  4PWB A;  3W8Z A;  3AMZ A;  3JS8 A;  3NRZ B;  4MLA A;  5FXP A;  2W3R A;  5FXD A;  5HMR A;  2Y08 A;  1W1O A;  2O3G A;  2QPM A;  4ZOH B;  3VTE A;  3D2J A;  2MBR A;  1ZR6 A;  2GQU A;  3NS1 B;  3PQB A;  1WVF A;  1QLT A;  2Y3S A;  1W1Q A;  2P13 A;  3LAE A;  3S1F A;  2IPI A;  1VAO A;  4OAL A;  3FWA A;  3NVV B;  1JRO A;  4XLO A;  2P4P A;  5L6G A;  3EJE B;  2NQW A;  5AE2 A;  1JRP A;  5HQX A;  2Y4G A;  3D2H A;  3I99 A;  1FIQ B;  2EXR A;  1MBB A;  3B9J B;  4PZF A;  2RK5 A;  2PLS A;  5FXF A;  1V97 A;  2W55 A;  4PWC A;  3EJD B;  4BC9 A;  1E8F A;  3SR6 B;  3AN1 A;  2BVF A;  2R8D A;  1N60 C;  2GQT A;  2VFV A;  3BW7 A;  4PVE A;  3W8W A;  1AHV A;  3TSJ A;  3NVW B;  1E8H A;  1WYG A;  3NVZ B;  2OAI A;  3HRD C;  1ZXI C;  1W1K A;  1DIQ A;  1FFU C;  1I19 A; 
#chains in the Genus database with same CATH homology
 2UUU A;  5D79 A;  3S1E A;  1W1S A;  3D2D A;  1DZN A;  2UUV A;  1N61 C;  1FFV C;  2BVG A;  3EUB 3;  5HHZ A;  2PLI A;  3S1D A;  1UXY A;  2E3T A;  4BC7 A;  3DQ0 A;  4PVK A;  4EC3 A;  5L6F A;  1W1L A;  5K8E A;  3TX1 A;  4DNS A;  2W3S A;  3PM9 A;  1QLU A;  2Y3R A;  4ML8 A;  1W1J A;  4BCA A;  1W1R A;  3FW8 A;  5AE3 A;  4JB1 A;  2W54 A;  3W8X A;  2WDW A;  2BVH A;  1RM6 B;  3FW9 A;  4PVH A;  4BBY A;  5AE1 A;  4O95 A;  1T3Q C;  3HSU A;  1E8G A;  1N62 C;  3POP A;  4PYT A;  3S1C A;  4JAY A;  3AM9 A;  2Q4W A;  3LLB A;  2YVS A;  4PVJ A;  3KJM A;  2VFT A;  3C0P A;  3TSH A;  2P3H A;  3ETR B;  1N5X A;  4HG0 A;  1E0Y A;  1F0X A;  1AHZ A;  3DED A;  3RJ8 A;  2VFU A;  5G5G B;  2Q85 A;  1N5W C;  1SB3 B;  5ADZ A;  4UD8 A;  2AXR A;  3NVY B;  1DII A;  5G5H B;  2VAO A;  1VDV A;  3FW7 A;  2R2Z A;  5I1V A;  5FXE A;  1MBT A;  3GSY A;  1WVE A;  1HSK A;  2VFR A;  2QKN A;  1W1M A;  3RJA A;  5I1W A;  1N63 C;  5AWV A;  2VFS A;  1FO4 A;  1AHU A;  2I0K A;  4PWB A;  3W8Z A;  3AMZ A;  3JS8 A;  3NRZ B;  4MLA A;  5FXP A;  2W3R A;  5FXD A;  5HMR A;  2Y08 A;  1W1O A;  2O3G A;  2QPM A;  4ZOH B;  3VTE A;  3D2J A;  2MBR A;  1ZR6 A;  2GQU A;  3NS1 B;  3PQB A;  1WVF A;  1QLT A;  2Y3S A;  1W1Q A;  2P13 A;  3LAE A;  3S1F A;  2IPI A;  1VAO A;  4OAL A;  3FWA A;  3NVV B;  1JRO A;  4XLO A;  2P4P A;  5L6G A;  2NQW A;  5AE2 A;  1JRP A;  5HQX A;  2Y4G A;  3D2H A;  3I99 A;  1FIQ B;  2EXR A;  1MBB A;  3B9J B;  4PZF A;  2RK5 A;  2PLS A;  5FXF A;  1V97 A;  2W55 A;  4PWC A;  4BC9 A;  1E8F A;  3SR6 B;  3AN1 A;  2BVF A;  2R8D A;  1N60 C;  2GQT A;  2VFV A;  3BW7 A;  4PVE A;  3W8W A;  1AHV A;  3TSJ A;  3NVW B;  1E8H A;  1WYG A;  3NVZ B;  2OAI A;  3HRD C;  1ZXI C;  1W1K A;  1DIQ A;  1FFU C;  1I19 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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