1W1KA

Structure of the octameric flavoenzyme vanillyl-alcohol oxidase: ile238thr mutant
Total Genus 182
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
182
sequence length
555
structure length
550
Chain Sequence
EFRPLTLPPKLSLSDFNEFIQDIIRIVGSENVEVISVDGSYMKPTHTHDPHHVMDQDYFLASAIVAPRNVADVQSIVGLANKFSFPLWPISIGRNSGYGGAAPRVSGSVVLDMGKNMNRVLEVNVEGAYCVVEPGVTYHDLHNYLEANNLRDKLWLDVPDLGGGSVLGNAVERGVGYTPYGDHWMMHSGMEVVLANGELLRTGMGALPDPKRPETMGLKPEDQPWSKTAHLFPYGFGPYIDGLFSQSNMGIVTKIGIWLMPNPRGYQSYLITLPKDGDLKQAVDIIRPLRLGMALQNVPTIRHILLDAAVLGDKRSYSSRTEPLSDEELDKIAKQLNLGRWNFYGALYGPEPIRRVLWETIKDAFSAIPGVKFYFPEDTPENSVLRVRDKTMQGIPTYDELKWIDWLPNGAHLFFSPIAKVSGEDAMMQYAVTKKRCQEAGLDFIGTFTVGMREMHHIVCIVFNKKDLIQKRKVQWLMRTLIDDCAANGWGEYRTHLAFMDQIMETYNWNNSSFLRFNEVLKNAVDPNGIIAPGKSGVWPSQYSHVTWKL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Laboratory-Evolved Vanillyl-Alcohol Oxidase Produces Natural Vanillin
pubmed doi rcsb
source organism Penicillium simplicissimum
molecule tags Oxidoreductase
molecule keywords VANILLYL-ALCOHOL OXIDASE
total genus 182
structure length 550
sequence length 555
chains with identical sequence B
ec nomenclature ec 1.1.3.38: Vanillyl-alcohol oxidase.
pdb deposition date 2004-06-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01565 FAD_binding_4 FAD binding domain
A PF02913 FAD-oxidase_C FAD linked oxidases, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.45.10 Mainly Alpha Orthogonal Bundle Vanillyl-alcohol Oxidase; Chain A, domain 4 Vanillyl-alcohol Oxidase; Chain A, domain 4 1w1kA04
3.30.43.10 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2 1w1kA01
3.30.465.10 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 1w1kA02
3.40.462.10 Alpha Beta 3-Layer(aba) Sandwich Vanillyl-alcohol Oxidase; Chain A, domain 3 FAD-linked oxidases, C-terminal domain 1w1kA03
4ML8A 1N5XA 4PWBA 5AE3A 1W1QA 5HHZA 3AM9A 3FW9A 1JRPA 1WYGA 3PM9A 1E8HA 1N62C 5FXDA 3GSYA 4PVJA 2P3HA 1V97A 1FFVC 2R8DA 2W3RA 2GQUA 2P13A 3W8XA 4BBYA 3S1DA 5FXEA 2Q85A 2BVGA 4JB1A 1QLTA 1W1OA 3NS1B 1MBBA 3BW7A 2PLSA 4UD8A 1DZNA 4PVEA 4PVHA 3VTEA 3B9JB 1FO4A 1E8FA 3D2JA 4PWCA 2VAOA 3S1EA 1T3QC 3S1CA 3JS8A 5G5HB 1E0YA 3NVZB 2PLIA 1ZR6A 2P4PA 5D79A 4HG0A 2YVSA 4BC9A 5FXPA 1I19A 1VDVA 1UXYA 3NRZB 4PVKA 4BC7A 2GQTA 5FXFA 2R2ZA 1W1LA 5ADZA 1FIQB 3TX1A 2NQWA 1JROA 2AXRA 3HRDC 1N60C 5HQXA 1N63C 4BCAA 3D2HA 2VFUA 4OALA 3S1FA 3LAEA 4MLAA 4ZOHB 1WVFA 1DIIA 3TSHA 1N5WC 4EC3A 1SB3B 3LLBA 1HSKA 2I0KA 1AHUA 2VFVA 3I99A 3DEDA 4PYTA 2EXRA 3FW8A 3FW7A 3W8ZA 5AE1A 3TSJA 2VFSA 3W8WA 2W55A 2OAIA 1W1SA 2W54A 2QPMA 3KJMA 3AMZA 1VAOA 3FWAA 1E8GA 3NVVB 2MBRA 1W1JA 1WVEA 3NVYB 2VFRA 1ZXIC 4DNSA 1MBTA 2VFTA 1F0XA 2QKNA 3EUB3 1W1MA 2BVHA 2O3GA 2Q4WA 1DIQA 2W3SA 2E3TA 3C0PA 5HMRA 1AHZA 3AN1A 1RM6B 2RK5A 1W1KA 2BVFA 3SR6B 1FFUC 1QLUA 3ETRB 1AHVA 1N61C 1W1RA 3NVWB 4XLOA 4O95A 3DQ0A 5G5GB 5AE2A 4JAYA 4PZFA 3D2DA
chains in the Genus database with same CATH superfamily
4ML8A 1N5XA 4PWBA 5AE3A 2Y3RA 1W1QA 5HHZA 3AM9A 3FW9A 1JRPA 1WYGA 3PM9A 1E8HA 1N62C 5FXDA 3GSYA 4PVJA 2P3HA 1V97A 3EJEB 1FFVC 2R8DA 2W3RA 2UUVA 2GQUA 2P13A 3W8XA 4BBYA 3S1DA 5FXEA 2Q85A 2BVGA 5I1WA 4JB1A 1QLTA 1W1OA 3NS1B 1MBBA 3BW7A 2PLSA 4UD8A 1DZNA 4PVEA 4PVHA 3VTEA 3B9JB 1FO4A 1E8FA 3D2JA 4PWCA 2VAOA 3S1EA 1T3QC 3S1CA 3JS8A 5G5HB 2Y08A 1E0YA 3NVZB 2PLIA 1ZR6A 2P4PA 5D79A 5L6GA 4HG0A 2YVSA 5AWVA 5I1VA 4BC9A 5FXPA 1I19A 1VDVA 1UXYA 3NRZB 4PVKA 4BC7A 2GQTA 5FXFA 3POPA 2R2ZA 1W1LA 5ADZA 1FIQB 3TX1A 3RJAA 2NQWA 1JROA 2AXRA 3HRDC 1N60C 5HQXA 1N63C 4BCAA 3D2HA 2VFUA 4OALA 3S1FA 3LAEA 3EJBB 4MLAA 4ZOHB 1WVFA 1DIIA 3TSHA 1N5WC 4EC3A 1SB3B 3LLBA 1HSKA 2I0KA 1AHUA 2VFVA 3I99A 2WDWA 4PYTA 3DEDA 2EXRA 3FW8A 3FW7A 3W8ZA 5K8EA 5AE1A 3TSJA 3RJ8A 2VFSA 3W8WA 2Y4GA 3PQBA 2W55A 2OAIA 1W1SA 2W54A 2QPMA 3KJMA 2IPIA 3AMZA 1VAOA 3EJDB 1E8GA 3FWAA 2MBRA 3NVVB 1W1JA 1WVEA 3NVYB 2VFRA 1ZXIC 4DNSA 3HSUA 1MBTA 2VFTA 1F0XA 2QKNA 3EUB3 1W1MA 2BVHA 2O3GA 2Q4WA 1DIQA 2W3SA 2E3TA 3C0PA 5HMRA 1AHZA 3AN1A 1RM6B 2UUUA 2RK5A 1W1KA 2BVFA 3SR6B 1FFUC 1QLUA 3ETRB 1AHVA 1N61C 2Y3SA 1W1RA 3NVWB 4XLOA 5L6FA 4O95A 3DQ0A 5G5GB 5AE2A 4JAYA 4PZFA 3D2DA
chains in the Genus database with same CATH topology
4ML8A 1N5XA 4PWBA 5AE3A 2Y3RA 1W1QA 5HHZA 3AM9A 3FW9A 1JRPA 1WYGA 3PM9A 1E8HA 1N62C 5FXDA 3GSYA 4PVJA 2P3HA 1V97A 1FFVC 2R8DA 2W3RA 2UUVA 2GQUA 2P13A 3W8XA 4BBYA 3S1DA 5FXEA 2Q85A 2BVGA 5I1WA 4JB1A 1QLTA 1W1OA 3NS1B 1MBBA 3BW7A 2PLSA 4UD8A 1DZNA 4PVEA 4PVHA 3VTEA 3B9JB 1FO4A 1E8FA 3D2JA 4PWCA 2VAOA 3S1EA 1T3QC 3S1CA 3JS8A 5G5HB 2Y08A 1E0YA 3NVZB 2PLIA 1ZR6A 2P4PA 5D79A 5L6GA 4HG0A 2YVSA 5AWVA 5I1VA 4BC9A 5FXPA 1I19A 1VDVA 1UXYA 3NRZB 4PVKA 4BC7A 2GQTA 5FXFA 3POPA 2R2ZA 1W1LA 5ADZA 1FIQB 3TX1A 3RJAA 2NQWA 1JROA 2AXRA 3HRDC 1N60C 5HQXA 1N63C 4BCAA 3D2HA 2VFUA 4OALA 3S1FA 3LAEA 4MLAA 4ZOHB 1WVFA 1DIIA 3TSHA 1N5WC 4EC3A 1SB3B 3LLBA 1HSKA 2I0KA 1AHUA 2VFVA 3I99A 2WDWA 4PYTA 3DEDA 2EXRA 3FW8A 3FW7A 3W8ZA 5K8EA 5AE1A 3TSJA 3RJ8A 2VFSA 3W8WA 2Y4GA 3PQBA 2W55A 2OAIA 1W1SA 2W54A 2QPMA 3KJMA 2IPIA 3AMZA 1VAOA 3FWAA 1E8GA 3NVVB 2MBRA 1W1JA 1WVEA 3NVYB 2VFRA 1ZXIC 4DNSA 3HSUA 1MBTA 2VFTA 1F0XA 2QKNA 3EUB3 1W1MA 2BVHA 2O3GA 2Q4WA 1DIQA 2W3SA 2E3TA 3C0PA 5HMRA 1AHZA 3AN1A 1RM6B 2UUUA 2RK5A 1W1KA 2BVFA 3SR6B 1FFUC 1QLUA 3ETRB 1AHVA 1N61C 2Y3SA 1W1RA 3NVWB 4XLOA 5L6FA 4O95A 3DQ0A 5G5GB 5AE2A 4JAYA 4PZFA 3D2DA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ML8 A;  1N5X A;  4PWB A;  5AE3 A;  1W1Q A;  5HHZ A;  3AM9 A;  3FW9 A;  1JRP A;  1WYG A;  3PM9 A;  1E8H A;  1N62 C;  5FXD A;  3GSY A;  4PVJ A;  2P3H A;  1V97 A;  1FFV C;  2R8D A;  2W3R A;  2GQU A;  2P13 A;  3W8X A;  4BBY A;  3S1D A;  5FXE A;  2Q85 A;  2BVG A;  4JB1 A;  1QLT A;  1W1O A;  3NS1 B;  1MBB A;  3BW7 A;  2PLS A;  4UD8 A;  1DZN A;  4PVE A;  4PVH A;  3VTE A;  3B9J B;  1FO4 A;  1E8F A;  3D2J A;  4PWC A;  2VAO A;  3S1E A;  1T3Q C;  3S1C A;  3JS8 A;  5G5H B;  1E0Y A;  3NVZ B;  2PLI A;  1ZR6 A;  2P4P A;  5D79 A;  4HG0 A;  2YVS A;  4BC9 A;  5FXP A;  1I19 A;  1VDV A;  1UXY A;  3NRZ B;  4PVK A;  4BC7 A;  2GQT A;  5FXF A;  2R2Z A;  1W1L A;  5ADZ A;  1FIQ B;  3TX1 A;  2NQW A;  1JRO A;  2AXR A;  3HRD C;  1N60 C;  5HQX A;  1N63 C;  4BCA A;  3D2H A;  2VFU A;  4OAL A;  3S1F A;  3LAE A;  4MLA A;  4ZOH B;  1WVF A;  1DII A;  3TSH A;  1N5W C;  4EC3 A;  1SB3 B;  3LLB A;  1HSK A;  2I0K A;  1AHU A;  2VFV A;  3I99 A;  3DED A;  4PYT A;  2EXR A;  3FW8 A;  3FW7 A;  3W8Z A;  5AE1 A;  3TSJ A;  2VFS A;  3W8W A;  2W55 A;  2OAI A;  1W1S A;  2W54 A;  2QPM A;  3KJM A;  3AMZ A;  1VAO A;  3FWA A;  1E8G A;  3NVV B;  2MBR A;  1W1J A;  1WVE A;  3NVY B;  2VFR A;  1ZXI C;  4DNS A;  1MBT A;  2VFT A;  1F0X A;  2QKN A;  3EUB 3;  1W1M A;  2BVH A;  2O3G A;  2Q4W A;  1DIQ A;  2W3S A;  2E3T A;  3C0P A;  5HMR A;  1AHZ A;  3AN1 A;  1RM6 B;  2RK5 A;  1W1K A;  2BVF A;  3SR6 B;  1FFU C;  1QLU A;  3ETR B;  1AHV A;  1N61 C;  1W1R A;  3NVW B;  4XLO A;  4O95 A;  3DQ0 A;  5G5G B;  5AE2 A;  4JAY A;  4PZF A;  3D2D A; 
#chains in the Genus database with same CATH topology
 4ML8 A;  1N5X A;  4PWB A;  5AE3 A;  2Y3R A;  1W1Q A;  5HHZ A;  3AM9 A;  3FW9 A;  1JRP A;  1WYG A;  3PM9 A;  1E8H A;  1N62 C;  5FXD A;  3GSY A;  4PVJ A;  2P3H A;  1V97 A;  3EJE B;  1FFV C;  2R8D A;  2W3R A;  2UUV A;  2GQU A;  2P13 A;  3W8X A;  4BBY A;  3S1D A;  5FXE A;  2Q85 A;  2BVG A;  5I1W A;  4JB1 A;  1QLT A;  1W1O A;  3NS1 B;  1MBB A;  3BW7 A;  2PLS A;  4UD8 A;  1DZN A;  4PVE A;  4PVH A;  3VTE A;  3B9J B;  1FO4 A;  1E8F A;  3D2J A;  4PWC A;  2VAO A;  3S1E A;  1T3Q C;  3S1C A;  3JS8 A;  5G5H B;  2Y08 A;  1E0Y A;  3NVZ B;  2PLI A;  1ZR6 A;  2P4P A;  5D79 A;  5L6G A;  4HG0 A;  2YVS A;  5AWV A;  5I1V A;  4BC9 A;  5FXP A;  1I19 A;  1VDV A;  1UXY A;  3NRZ B;  4PVK A;  4BC7 A;  2GQT A;  5FXF A;  3POP A;  2R2Z A;  1W1L A;  5ADZ A;  1FIQ B;  3TX1 A;  3RJA A;  2NQW A;  1JRO A;  2AXR A;  3HRD C;  1N60 C;  5HQX A;  1N63 C;  4BCA A;  3D2H A;  2VFU A;  4OAL A;  3S1F A;  3LAE A;  3EJB B;  4MLA A;  4ZOH B;  1WVF A;  1DII A;  3TSH A;  1N5W C;  4EC3 A;  1SB3 B;  3LLB A;  1HSK A;  2I0K A;  1AHU A;  2VFV A;  3I99 A;  2WDW A;  4PYT A;  3DED A;  2EXR A;  3FW8 A;  3FW7 A;  3W8Z A;  5K8E A;  5AE1 A;  3TSJ A;  3RJ8 A;  2VFS A;  3W8W A;  2Y4G A;  3PQB A;  2W55 A;  2OAI A;  1W1S A;  2W54 A;  2QPM A;  3KJM A;  2IPI A;  3AMZ A;  1VAO A;  3EJD B;  1E8G A;  3FWA A;  2MBR A;  3NVV B;  1W1J A;  1WVE A;  3NVY B;  2VFR A;  1ZXI C;  4DNS A;  3HSU A;  1MBT A;  2VFT A;  1F0X A;  2QKN A;  3EUB 3;  1W1M A;  2BVH A;  2O3G A;  2Q4W A;  1DIQ A;  2W3S A;  2E3T A;  3C0P A;  5HMR A;  1AHZ A;  3AN1 A;  1RM6 B;  2UUU A;  2RK5 A;  1W1K A;  2BVF A;  3SR6 B;  1FFU C;  1QLU A;  3ETR B;  1AHV A;  1N61 C;  2Y3S A;  1W1R A;  3NVW B;  4XLO A;  5L6F A;  4O95 A;  3DQ0 A;  5G5G B;  5AE2 A;  4JAY A;  4PZF A;  3D2D A; 
#chains in the Genus database with same CATH homology
 4ML8 A;  1N5X A;  4PWB A;  5AE3 A;  2Y3R A;  1W1Q A;  5HHZ A;  3AM9 A;  3FW9 A;  1JRP A;  1WYG A;  3PM9 A;  1E8H A;  1N62 C;  5FXD A;  3GSY A;  4PVJ A;  2P3H A;  1V97 A;  1FFV C;  2R8D A;  2W3R A;  2UUV A;  2GQU A;  2P13 A;  3W8X A;  4BBY A;  3S1D A;  5FXE A;  2Q85 A;  2BVG A;  5I1W A;  4JB1 A;  1QLT A;  1W1O A;  3NS1 B;  1MBB A;  3BW7 A;  2PLS A;  4UD8 A;  1DZN A;  4PVE A;  4PVH A;  3VTE A;  3B9J B;  1FO4 A;  1E8F A;  3D2J A;  4PWC A;  2VAO A;  3S1E A;  1T3Q C;  3S1C A;  3JS8 A;  5G5H B;  2Y08 A;  1E0Y A;  3NVZ B;  2PLI A;  1ZR6 A;  2P4P A;  5D79 A;  5L6G A;  4HG0 A;  2YVS A;  5AWV A;  5I1V A;  4BC9 A;  5FXP A;  1I19 A;  1VDV A;  1UXY A;  3NRZ B;  4PVK A;  4BC7 A;  2GQT A;  5FXF A;  3POP A;  2R2Z A;  1W1L A;  5ADZ A;  1FIQ B;  3TX1 A;  3RJA A;  2NQW A;  1JRO A;  2AXR A;  3HRD C;  1N60 C;  5HQX A;  1N63 C;  4BCA A;  3D2H A;  2VFU A;  4OAL A;  3S1F A;  3LAE A;  4MLA A;  4ZOH B;  1WVF A;  1DII A;  3TSH A;  1N5W C;  4EC3 A;  1SB3 B;  3LLB A;  1HSK A;  2I0K A;  1AHU A;  2VFV A;  3I99 A;  2WDW A;  4PYT A;  3DED A;  2EXR A;  3FW8 A;  3FW7 A;  3W8Z A;  5K8E A;  5AE1 A;  3TSJ A;  3RJ8 A;  2VFS A;  3W8W A;  2Y4G A;  3PQB A;  2W55 A;  2OAI A;  1W1S A;  2W54 A;  2QPM A;  3KJM A;  2IPI A;  3AMZ A;  1VAO A;  3FWA A;  1E8G A;  3NVV B;  2MBR A;  1W1J A;  1WVE A;  3NVY B;  2VFR A;  1ZXI C;  4DNS A;  3HSU A;  1MBT A;  2VFT A;  1F0X A;  2QKN A;  3EUB 3;  1W1M A;  2BVH A;  2O3G A;  2Q4W A;  1DIQ A;  2W3S A;  2E3T A;  3C0P A;  5HMR A;  1AHZ A;  3AN1 A;  1RM6 B;  2UUU A;  2RK5 A;  1W1K A;  2BVF A;  3SR6 B;  1FFU C;  1QLU A;  3ETR B;  1AHV A;  1N61 C;  2Y3S A;  1W1R A;  3NVW B;  4XLO A;  5L6F A;  4O95 A;  3DQ0 A;  5G5G B;  5AE2 A;  4JAY A;  4PZF A;  3D2D A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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