1W22A

Crystal structure of inhibited human hdac8
Total Genus 122
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
122
sequence length
362
structure length
352
Chain Sequence
SLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords HISTONE DEACETYLASE 8
publication title Crystal Structure of a Eukaryotic Zn-Dependent Histone Deacetylase,Human Hdac8,Complexed with a Hydroxamic Acid Inhibitor
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 122
structure length 352
sequence length 362
chains with identical sequence B
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2004-06-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 1w22A00
3C0YA 5G1BA 2VQOA 4QA3A 5G1AA 1VKGA 3MZ3A 5FCWA 5THUA 2VQWG 5EF8A 5EFBD 1C3SA 4CBYA 4QA6A 5THSA 5ICNB 5DC5A 4BZ7A 3EZTA 4ZURA 3MZ7A 4BZ8A 4LY1A 5BWZA 3MZ6A 4ZUQA 3ZNSA 5G0HA 3Q9EA 1T67A 1W22A 4ZUNA 5LI3A 4ZUOA 5G0XA 4RN1A 4ZUMA 4QA2A 5EF7A 5DC8A 4QA0A 5G13A 4QA1A 5JI5A 3RQDA 3SFHA 4CQFA 5IX0A 5THTA 4A69A 5DC6A 5EFKB 4BZ6A 5EFNA 3MAXA 2V5XA 3Q9BA 4BZ9A 4RN0A 3ZNRA 3C0ZA 1ZZ0A 1C3RA 5EEIA 3F06A 5G12A 5EFGA 5EEFA 5FUEA 5D1BA 5EEKA 5EFJD 4BKXB 5G0YA 5A2SA 4ZUPA 2VQMA 4QA7A 2VCGA 5G17A 4RN2A 3Q9CA 1T69A 4QA4A 1ZZ3A 5G1CA 3EW8A 3C10A 3F07A 5DC7A 1C3PA 1ZZ1A 2VQQA 3EWFA 5D1DA 5EENA 2V5WA 5EFHA 5IWGA 2GH6A 4LXZA 3MENA 3Q9FA 4BZ5A 5G10A 2VQJA 3SFFA 5THVA 5G0JA 1T64A 4QA5A 3EZPA 5D1CA 5G0IA 4CBTA 5G0GA 3F0RA 5G11A 5G3WA 2VQVA 5EEMA 3MZ4A
chains in the Genus database with same CATH superfamily
1D3VA 1T4PA 3C0YA 5G1BA 2VQOA 4G3HA 4QA3A 1P8SA 1P8NA 5G1AA 2AEBA 4FCIA 1VKGA 1XFKA 3MZ3A 5FCWA 5THUA 3DJ8A 2VQWG 1P8QA 5CEVA 4Q42A 5EF8A 2RLAA 4GSVA 5EFBD 3THJA 3MMRA 3SL0A 1C3SA 1TBHA 4QA6A 3TH7A 3SJTA 5THSA 4CBYA 2CEVA 1P8MA 5DC5A 4BZ7A 2PHAA 3EZTA 4ZURA 3E8ZA 5ICNB 1PQ3A 3MZ7A 2EIVA 4RHMA 4BZ8A 4LY1A 3E6KA 4MXRA 1TA1A 5BWZA 3LP4A 3MZ6A 4ZUQA 3ZNSA 5G0HA 4IU1A 2PHOA 3Q9EA 1GQ7A 4RHKA 1T67A 4GSMA 1W22A 4ZUNA 5LI3A 4GWDA 4Q40A 3NIPA 4RHIA 1ZPGA 4Q3RC 4ZUOA 5G0XA 4RN1A 5RLAA 3NIOA 4ZUMA 4QA2A 4RHQA 4Q3UA 5EF7A 3TF3A 4HXQA 4MYFA 5DC8A 3MJLA 4QA0A 4FCKA 5G13A 3MFWA 4QA1A 5HJAA 5JI5A 4IU0A 4ITYA 4HWWA 1WVBA 3RQDA 3SFHA 4CQFA 5IX0A 5THTA 4A69A 5DC6A 5EFKB 4BZ6A 4IE1A 5EFNA 1T4RA 2V5XA 3MAXA 3MFVA 3Q9BA 4GSZA 4MYNA 4BZ9A 4RN0A 3ZNRA 3C0ZA 1ZZ0A 1C3RA 1HQFA 1P8PA 5EEIA 3F06A 5G12A 1HQ5A 5EFGA 1R1OA 4I06A 1T4TA 3M1RA 5EEFA 4RHJA 5FUEA 3LP7A 5D1BA 5EEKA 4IE2A 5EFJD 4DZ4A 4BKXB 3PZLA 5G0YA 1T4SA 5A2SA 4ZUPA 2VQMA 2EF5A 1WOIA 3THEA 1ZPEA 4Q3VA 1HQXA 4QA7A 2VCGA 3SL1A 1T5GA 5G17A 4RN2A 1CEVA 3Q9CA 1T69A 3E6VA 4IXUA 1TBLA 4QA4A 1HQHA 1ZZ3A 3CEVA 2PLLA 4RLAA 4Q3SA 3EW8A 3C10A 3F07A 5G1CA 1RLAA 3GN0A 5DC7A 3SKKA 1C3PA 1ZZ1A 2VQQA 2ZAVA 3KV2A 3RLAA 4RHLA 4Q3RA 3GMZA 3F80A 3EWFA 1WVAA 1P8RA 4HZEA 5D1DA 4IXVA 2V5WA 5EENA 4Q3TA 5EFHA 5IWGA 3E9BA 5HJ9A 3NIQA 2GH6A 4LXZA 3MENA 3Q9FA 4BZ5A 5G10A 2VQJA 1WOGA 1HQGA 4Q3PA 1TBJA 3SFFA 3THHA 1T5FA 4GWCA 5THVA 4Q41A 4IE3A 4CEVA 1P8OA 4Q3QA 5G0JA 1T64A 1GQ6A 4QA5A 3EZPA 4IU5A 2EF4A 4MYLA 5D1CA 5G0IA 4IU4A 4CBTA 3LHLA 3E8QA 5G0GA 3F0RA 5G11A 5G3WA 2VQVA 5EEMA 3MZ4A 2A0MA 1WOHA 4MYKA
chains in the Genus database with same CATH topology
3C0YA 5G1BA 2VQOA 4QA3A 5G1AA 1VKGA 3MZ3A 5FCWA 5THUA 2VQWG 5EF8A 5EFBD 1C3SA 4CBYA 4QA6A 5THSA 5ICNB 5DC5A 4BZ7A 3EZTA 4ZURA 3MZ7A 4BZ8A 4LY1A 5BWZA 3MZ6A 4ZUQA 3ZNSA 5G0HA 3Q9EA 1T67A 1W22A 4ZUNA 5LI3A 4ZUOA 5G0XA 4RN1A 4ZUMA 4QA2A 5EF7A 5DC8A 4QA0A 5G13A 4QA1A 5JI5A 3RQDA 3SFHA 4CQFA 5IX0A 5THTA 4A69A 5DC6A 5EFKB 4BZ6A 5EFNA 3MAXA 2V5XA 3Q9BA 4BZ9A 4RN0A 3ZNRA 3C0ZA 1ZZ0A 1C3RA 5EEIA 3F06A 5G12A 5EFGA 5EEFA 5FUEA 5D1BA 5EEKA 5EFJD 4BKXB 5G0YA 5A2SA 4ZUPA 2VQMA 4QA7A 2VCGA 5G17A 4RN2A 3Q9CA 1T69A 4QA4A 1ZZ3A 5G1CA 3EW8A 3C10A 3F07A 5DC7A 1C3PA 1ZZ1A 2VQQA 3EWFA 5D1DA 5EENA 2V5WA 5EFHA 5IWGA 2GH6A 4LXZA 3MENA 3Q9FA 4BZ5A 5G10A 2VQJA 3SFFA 5THVA 5G0JA 1T64A 4QA5A 3EZPA 5D1CA 5G0IA 4CBTA 5G0GA 3F0RA 5G11A 5G3WA 2VQVA 5EEMA 3MZ4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3C0Y A;  5G1B A;  2VQO A;  4QA3 A;  5G1A A;  1VKG A;  3MZ3 A;  5FCW A;  5THU A;  2VQW G;  5EF8 A;  5EFB D;  1C3S A;  4CBY A;  4QA6 A;  5THS A;  5ICN B;  5DC5 A;  4BZ7 A;  3EZT A;  4ZUR A;  3MZ7 A;  4BZ8 A;  4LY1 A;  5BWZ A;  3MZ6 A;  4ZUQ A;  3ZNS A;  5G0H A;  3Q9E A;  1T67 A;  1W22 A;  4ZUN A;  5LI3 A;  4ZUO A;  5G0X A;  4RN1 A;  4ZUM A;  4QA2 A;  5EF7 A;  5DC8 A;  4QA0 A;  5G13 A;  4QA1 A;  5JI5 A;  3RQD A;  3SFH A;  4CQF A;  5IX0 A;  5THT A;  4A69 A;  5DC6 A;  5EFK B;  4BZ6 A;  5EFN A;  3MAX A;  2V5X A;  3Q9B A;  4BZ9 A;  4RN0 A;  3ZNR A;  3C0Z A;  1ZZ0 A;  1C3R A;  5EEI A;  3F06 A;  5G12 A;  5EFG A;  5EEF A;  5FUE A;  5D1B A;  5EEK A;  5EFJ D;  4BKX B;  5G0Y A;  5A2S A;  4ZUP A;  2VQM A;  4QA7 A;  2VCG A;  5G17 A;  4RN2 A;  3Q9C A;  1T69 A;  4QA4 A;  1ZZ3 A;  5G1C A;  3EW8 A;  3C10 A;  3F07 A;  5DC7 A;  1C3P A;  1ZZ1 A;  2VQQ A;  3EWF A;  5D1D A;  5EEN A;  2V5W A;  5EFH A;  5IWG A;  2GH6 A;  4LXZ A;  3MEN A;  3Q9F A;  4BZ5 A;  5G10 A;  2VQJ A;  3SFF A;  5THV A;  5G0J A;  1T64 A;  4QA5 A;  3EZP A;  5D1C A;  5G0I A;  4CBT A;  5G0G A;  3F0R A;  5G11 A;  5G3W A;  2VQV A;  5EEM A;  3MZ4 A; 
#chains in the Genus database with same CATH topology
 1D3V A;  1T4P A;  3C0Y A;  5G1B A;  2VQO A;  4G3H A;  4QA3 A;  1P8S A;  1P8N A;  5G1A A;  2AEB A;  4FCI A;  1VKG A;  1XFK A;  3MZ3 A;  5FCW A;  5THU A;  3DJ8 A;  2VQW G;  1P8Q A;  5CEV A;  4Q42 A;  5EF8 A;  2RLA A;  4GSV A;  5EFB D;  3THJ A;  3MMR A;  3SL0 A;  1C3S A;  1TBH A;  4QA6 A;  3TH7 A;  3SJT A;  5THS A;  4CBY A;  2CEV A;  1P8M A;  5DC5 A;  4BZ7 A;  2PHA A;  3EZT A;  4ZUR A;  3E8Z A;  5ICN B;  1PQ3 A;  3MZ7 A;  2EIV A;  4RHM A;  4BZ8 A;  4LY1 A;  3E6K A;  4MXR A;  1TA1 A;  5BWZ A;  3LP4 A;  3MZ6 A;  4ZUQ A;  3ZNS A;  5G0H A;  4IU1 A;  2PHO A;  3Q9E A;  1GQ7 A;  4RHK A;  1T67 A;  4GSM A;  1W22 A;  4ZUN A;  5LI3 A;  4GWD A;  4Q40 A;  3NIP A;  4RHI A;  1ZPG A;  4Q3R C;  4ZUO A;  5G0X A;  4RN1 A;  5RLA A;  3NIO A;  4ZUM A;  4QA2 A;  4RHQ A;  4Q3U A;  5EF7 A;  3TF3 A;  4HXQ A;  4MYF A;  5DC8 A;  3MJL A;  4QA0 A;  4FCK A;  5G13 A;  3MFW A;  4QA1 A;  5HJA A;  5JI5 A;  4IU0 A;  4ITY A;  4HWW A;  1WVB A;  3RQD A;  3SFH A;  4CQF A;  5IX0 A;  5THT A;  4A69 A;  5DC6 A;  5EFK B;  4BZ6 A;  4IE1 A;  5EFN A;  1T4R A;  2V5X A;  3MAX A;  3MFV A;  3Q9B A;  4GSZ A;  4MYN A;  4BZ9 A;  4RN0 A;  3ZNR A;  3C0Z A;  1ZZ0 A;  1C3R A;  1HQF A;  1P8P A;  5EEI A;  3F06 A;  5G12 A;  1HQ5 A;  5EFG A;  1R1O A;  4I06 A;  1T4T A;  3M1R A;  5EEF A;  4RHJ A;  5FUE A;  3LP7 A;  5D1B A;  5EEK A;  4IE2 A;  5EFJ D;  4DZ4 A;  4BKX B;  3PZL A;  5G0Y A;  1T4S A;  5A2S A;  4ZUP A;  2VQM A;  2EF5 A;  1WOI A;  3THE A;  1ZPE A;  4Q3V A;  1HQX A;  4QA7 A;  2VCG A;  3SL1 A;  1T5G A;  5G17 A;  4RN2 A;  1CEV A;  3Q9C A;  1T69 A;  3E6V A;  4IXU A;  1TBL A;  4QA4 A;  1HQH A;  1ZZ3 A;  3CEV A;  2PLL A;  4RLA A;  4Q3S A;  3EW8 A;  3C10 A;  3F07 A;  5G1C A;  1RLA A;  3GN0 A;  5DC7 A;  3SKK A;  1C3P A;  1ZZ1 A;  2VQQ A;  2ZAV A;  3KV2 A;  3RLA A;  4RHL A;  4Q3R A;  3GMZ A;  3F80 A;  3EWF A;  1WVA A;  1P8R A;  4HZE A;  5D1D A;  4IXV A;  2V5W A;  5EEN A;  4Q3T A;  5EFH A;  5IWG A;  3E9B A;  5HJ9 A;  3NIQ A;  2GH6 A;  4LXZ A;  3MEN A;  3Q9F A;  4BZ5 A;  5G10 A;  2VQJ A;  1WOG A;  1HQG A;  4Q3P A;  1TBJ A;  3SFF A;  3THH A;  1T5F A;  4GWC A;  5THV A;  4Q41 A;  4IE3 A;  4CEV A;  1P8O A;  4Q3Q A;  5G0J A;  1T64 A;  1GQ6 A;  4QA5 A;  3EZP A;  4IU5 A;  2EF4 A;  4MYL A;  5D1C A;  5G0I A;  4IU4 A;  4CBT A;  3LHL A;  3E8Q A;  5G0G A;  3F0R A;  5G11 A;  5G3W A;  2VQV A;  5EEM A;  3MZ4 A;  2A0M A;  1WOH A;  4MYK A; 
#chains in the Genus database with same CATH homology
 3C0Y A;  5G1B A;  2VQO A;  4QA3 A;  5G1A A;  1VKG A;  3MZ3 A;  5FCW A;  5THU A;  2VQW G;  5EF8 A;  5EFB D;  1C3S A;  4CBY A;  4QA6 A;  5THS A;  5ICN B;  5DC5 A;  4BZ7 A;  3EZT A;  4ZUR A;  3MZ7 A;  4BZ8 A;  4LY1 A;  5BWZ A;  3MZ6 A;  4ZUQ A;  3ZNS A;  5G0H A;  3Q9E A;  1T67 A;  1W22 A;  4ZUN A;  5LI3 A;  4ZUO A;  5G0X A;  4RN1 A;  4ZUM A;  4QA2 A;  5EF7 A;  5DC8 A;  4QA0 A;  5G13 A;  4QA1 A;  5JI5 A;  3RQD A;  3SFH A;  4CQF A;  5IX0 A;  5THT A;  4A69 A;  5DC6 A;  5EFK B;  4BZ6 A;  5EFN A;  3MAX A;  2V5X A;  3Q9B A;  4BZ9 A;  4RN0 A;  3ZNR A;  3C0Z A;  1ZZ0 A;  1C3R A;  5EEI A;  3F06 A;  5G12 A;  5EFG A;  5EEF A;  5FUE A;  5D1B A;  5EEK A;  5EFJ D;  4BKX B;  5G0Y A;  5A2S A;  4ZUP A;  2VQM A;  4QA7 A;  2VCG A;  5G17 A;  4RN2 A;  3Q9C A;  1T69 A;  4QA4 A;  1ZZ3 A;  5G1C A;  3EW8 A;  3C10 A;  3F07 A;  5DC7 A;  1C3P A;  1ZZ1 A;  2VQQ A;  3EWF A;  5D1D A;  5EEN A;  2V5W A;  5EFH A;  5IWG A;  2GH6 A;  4LXZ A;  3MEN A;  3Q9F A;  4BZ5 A;  5G10 A;  2VQJ A;  3SFF A;  5THV A;  5G0J A;  1T64 A;  4QA5 A;  3EZP A;  5D1C A;  5G0I A;  4CBT A;  5G0G A;  3F0R A;  5G11 A;  5G3W A;  2VQV A;  5EEM A;  3MZ4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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