1X67A

Solution structure of the cofilin homology domain of hip-55 (drebrin-like protein)
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
146
structure length
146
Chain Sequence
GSSGSSGMAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSGKVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAEEDVEPECIMEKVASGPSSG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title NMR solution structures of actin depolymerizing factor homology domains.
pubmed doi rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords Drebrin-like protein
total genus 21
structure length 146
sequence length 146
ec nomenclature
pdb deposition date 2005-05-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00241 Cofilin_ADF Cofilin/tropomyosin-type actin-binding protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 1x67A01
1TVJA 1WNJA 5FAEA 1CNUA 5DD2A 4CBUG 2VACA 4BEX1 3EH1A 1T2LA 1F7SA 1P8ZG 3EG9A 2NUPA 4PKHB 1CFYA 5IVUA 3CIPG 1NPHA 1M2OA 2FH4A 2QTVA 1V6FA 2L72A 3A5LS 3CJCG 5KYXA 4PKGG 4Z94G 5KYWB 1D4XG 2HD7A 2KVKA 1EQYS 2LJ8A 1SVYA 1AK6A 3CI5G 1SVQA 3L50A 4LIZA 1COFA 2LLFA 1KCQA 1X67A 1ESVS 1PD1A 1NLVG 3EG9B 2VIKA 3EFOA 1YVNG 2NUPB 3EGXA 2I2QA 3EGDB 5KYUA 1WFSA 1NM1G 1PD0A 1PCXA 1AHQA 4S10C 5KYXB 1JHWA 2D8BA 1T44G 1SVRA 2MV2A 1T3YA 2XFAA 1DEJS 1VKKA 3FFKA 5KYYA 1M2VA 1VFQA 4KEFA 4CBWG 1UDMA 3FG7A 2LXXA 4JD2H 1HQZ1 1M4JA 3CJBG 3EFOB 1WM4A 1T3XA 3TU5B 3EGXB 2FGHA 1NMDG 1C0GS 3A5OS 1H1VG 5KYUB 1QPVA 5HVKB 3Q2BA 5A1MA 2FH1A 5FAFA 1P8XA 4PKIG 2NUTA 3A5MS 5KYNA 5HVKD 2FF3A 1Q8XA 1Q8GA 3EH2A 2MOTA 4KEDA 1YAGG 4CBXG 1RGIG 3DAWB 3A5NS 5KYYB 1M2VB 2FH2A 1MDUA 1D0NA 4KEEA 2VILA 3EGDA 2FH3A 2W0IA 3FG6A 1TMWA 1J72A 1C0FS 2FF6G 1AK7A 5L6WC 5KYWA 2NUTB 3FFNA 2XF1A 2MP4A
chains in the Genus database with same CATH superfamily
1TVJA 1WNJA 5FAEA 1CNUA 5DD2A 4CBUG 2VACA 4BEX1 3EH1A 1T2LA 1F7SA 1P8ZG 3EG9A 2NUPA 4PKHB 1CFYA 5IVUA 3CIPG 1NPHA 1M2OA 2FH4A 2QTVA 1V6FA 2L72A 3A5LS 3CJCG 5KYXA 4PKGG 4Z94G 5KYWB 1D4XG 2HD7A 2KVKA 1EQYS 2LJ8A 1SVYA 3DA7A 1AK6A 3CI5G 1SVQA 3L50A 4LIZA 1COFA 2LLFA 1KCQA 1X67A 1ESVS 1PD1A 1NLVG 3EG9B 2VIKA 3EFOA 1YVNG 2NUPB 3EGXA 2I2QA 3EGDB 5KYUA 1WFSA 1NM1G 1PD0A 1PCXA 1AHQA 4S10C 5KYXB 1JHWA 2D8BA 1T44G 1SVRA 2MV2A 1T3YA 2XFAA 1DEJS 1VKKA 3FFKA 5KYYA 1M2VA 1VFQA 4KEFA 4CBWG 1UDMA 3FG7A 2LXXA 4JD2H 1HQZ1 1M4JA 3CJBG 3EFOB 1WM4A 1T3XA 3TU5B 3EGXB 2FGHA 1NMDG 1C0GS 3A5OS 1H1VG 5KYUB 1QPVA 5HVKB 3Q2BA 5A1MA 2FH1A 5FAFA 1P8XA 4PKIG 2NUTA 3A5MS 5KYNA 5HVKD 2FF3A 1Q8XA 1Q8GA 3EH2A 2MOTA 4KEDA 1YAGG 4CBXG 1RGIG 3DAWB 3A5NS 5KYYB 1M2VB 2FH2A 1MDUA 1D0NA 4KEEA 2VILA 3EGDA 2FH3A 2W0IA 3FG6A 1TMWA 1J72A 1C0FS 2FF6G 1AK7A 5L6WC 5KYWA 2NUTB 3FFNA 2XF1A 2MP4A
chains in the Genus database with same CATH topology
1TVJA 1WNJA 5FAEA 1CNUA 5DD2A 4CBUG 2VACA 4BEX1 3EH1A 1T2LA 1F7SA 1P8ZG 3EG9A 2NUPA 4PKHB 1CFYA 5IVUA 3CIPG 1NPHA 1M2OA 2FH4A 2QTVA 1V6FA 2L72A 3A5LS 3CJCG 5KYXA 4PKGG 4Z94G 5KYWB 1D4XG 2HD7A 2KVKA 1EQYS 2LJ8A 1SVYA 3DA7A 1AK6A 3CI5G 1SVQA 3L50A 4LIZA 1COFA 2LLFA 1KCQA 1X67A 1ESVS 1PD1A 1NLVG 3EG9B 2VIKA 3EFOA 1YVNG 2NUPB 3EGXA 2I2QA 3EGDB 5KYUA 1WFSA 1NM1G 1PD0A 1PCXA 1AHQA 4S10C 5KYXB 1JHWA 2D8BA 1T44G 1SVRA 2MV2A 1T3YA 2XFAA 1DEJS 1VKKA 3FFKA 5KYYA 1M2VA 1VFQA 4KEFA 4CBWG 1UDMA 3FG7A 2LXXA 4JD2H 1HQZ1 1M4JA 3CJBG 3EFOB 1WM4A 1T3XA 3TU5B 3EGXB 2FGHA 1NMDG 1C0GS 3A5OS 1H1VG 5KYUB 1QPVA 5HVKB 3Q2BA 5A1MA 2FH1A 5FAFA 1P8XA 4PKIG 2NUTA 3A5MS 5KYNA 5HVKD 2FF3A 1Q8XA 1Q8GA 3EH2A 2MOTA 4KEDA 1YAGG 4CBXG 1RGIG 3DAWB 3A5NS 5KYYB 1M2VB 2FH2A 1MDUA 1D0NA 4KEEA 2VILA 3EGDA 2FH3A 2W0IA 3FG6A 1TMWA 1J72A 1C0FS 2FF6G 1AK7A 5L6WC 5KYWA 2NUTB 3FFNA 2XF1A 2MP4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TVJ A;  1WNJ A;  5FAE A;  1CNU A;  5DD2 A;  4CBU G;  2VAC A;  4BEX 1;  3EH1 A;  1T2L A;  1F7S A;  1P8Z G;  3EG9 A;  2NUP A;  4PKH B;  1CFY A;  5IVU A;  3CIP G;  1NPH A;  1M2O A;  2FH4 A;  2QTV A;  1V6F A;  2L72 A;  3A5L S;  3CJC G;  5KYX A;  4PKG G;  4Z94 G;  5KYW B;  1D4X G;  2HD7 A;  2KVK A;  1EQY S;  2LJ8 A;  1SVY A;  1AK6 A;  3CI5 G;  1SVQ A;  3L50 A;  4LIZ A;  1COF A;  2LLF A;  1KCQ A;  1X67 A;  1ESV S;  1PD1 A;  1NLV G;  3EG9 B;  2VIK A;  3EFO A;  1YVN G;  2NUP B;  3EGX A;  2I2Q A;  3EGD B;  5KYU A;  1WFS A;  1NM1 G;  1PD0 A;  1PCX A;  1AHQ A;  4S10 C;  5KYX B;  1JHW A;  2D8B A;  1T44 G;  1SVR A;  2MV2 A;  1T3Y A;  2XFA A;  1DEJ S;  1VKK A;  3FFK A;  5KYY A;  1M2V A;  1VFQ A;  4KEF A;  4CBW G;  1UDM A;  3FG7 A;  2LXX A;  4JD2 H;  1HQZ 1;  1M4J A;  3CJB G;  3EFO B;  1WM4 A;  1T3X A;  3TU5 B;  3EGX B;  2FGH A;  1NMD G;  1C0G S;  3A5O S;  1H1V G;  5KYU B;  1QPV A;  5HVK B;  3Q2B A;  5A1M A;  2FH1 A;  5FAF A;  1P8X A;  4PKI G;  2NUT A;  3A5M S;  5KYN A;  5HVK D;  2FF3 A;  1Q8X A;  1Q8G A;  3EH2 A;  2MOT A;  4KED A;  1YAG G;  4CBX G;  1RGI G;  3DAW B;  3A5N S;  5KYY B;  1M2V B;  2FH2 A;  1MDU A;  1D0N A;  4KEE A;  2VIL A;  3EGD A;  2FH3 A;  2W0I A;  3FG6 A;  1TMW A;  1J72 A;  1C0F S;  2FF6 G;  1AK7 A;  5L6W C;  5KYW A;  2NUT B;  3FFN A;  2XF1 A;  2MP4 A; 
#chains in the Genus database with same CATH topology
 1TVJ A;  1WNJ A;  5FAE A;  1CNU A;  5DD2 A;  4CBU G;  2VAC A;  4BEX 1;  3EH1 A;  1T2L A;  1F7S A;  1P8Z G;  3EG9 A;  2NUP A;  4PKH B;  1CFY A;  5IVU A;  3CIP G;  1NPH A;  1M2O A;  2FH4 A;  2QTV A;  1V6F A;  2L72 A;  3A5L S;  3CJC G;  5KYX A;  4PKG G;  4Z94 G;  5KYW B;  1D4X G;  2HD7 A;  2KVK A;  1EQY S;  2LJ8 A;  1SVY A;  3DA7 A;  1AK6 A;  3CI5 G;  1SVQ A;  3L50 A;  4LIZ A;  1COF A;  2LLF A;  1KCQ A;  1X67 A;  1ESV S;  1PD1 A;  1NLV G;  3EG9 B;  2VIK A;  3EFO A;  1YVN G;  2NUP B;  3EGX A;  2I2Q A;  3EGD B;  5KYU A;  1WFS A;  1NM1 G;  1PD0 A;  1PCX A;  1AHQ A;  4S10 C;  5KYX B;  1JHW A;  2D8B A;  1T44 G;  1SVR A;  2MV2 A;  1T3Y A;  2XFA A;  1DEJ S;  1VKK A;  3FFK A;  5KYY A;  1M2V A;  1VFQ A;  4KEF A;  4CBW G;  1UDM A;  3FG7 A;  2LXX A;  4JD2 H;  1HQZ 1;  1M4J A;  3CJB G;  3EFO B;  1WM4 A;  1T3X A;  3TU5 B;  3EGX B;  2FGH A;  1NMD G;  1C0G S;  3A5O S;  1H1V G;  5KYU B;  1QPV A;  5HVK B;  3Q2B A;  5A1M A;  2FH1 A;  5FAF A;  1P8X A;  4PKI G;  2NUT A;  3A5M S;  5KYN A;  5HVK D;  2FF3 A;  1Q8X A;  1Q8G A;  3EH2 A;  2MOT A;  4KED A;  1YAG G;  4CBX G;  1RGI G;  3DAW B;  3A5N S;  5KYY B;  1M2V B;  2FH2 A;  1MDU A;  1D0N A;  4KEE A;  2VIL A;  3EGD A;  2FH3 A;  2W0I A;  3FG6 A;  1TMW A;  1J72 A;  1C0F S;  2FF6 G;  1AK7 A;  5L6W C;  5KYW A;  2NUT B;  3FFN A;  2XF1 A;  2MP4 A; 
#chains in the Genus database with same CATH homology
 1TVJ A;  1WNJ A;  5FAE A;  1CNU A;  5DD2 A;  4CBU G;  2VAC A;  4BEX 1;  3EH1 A;  1T2L A;  1F7S A;  1P8Z G;  3EG9 A;  2NUP A;  4PKH B;  1CFY A;  5IVU A;  3CIP G;  1NPH A;  1M2O A;  2FH4 A;  2QTV A;  1V6F A;  2L72 A;  3A5L S;  3CJC G;  5KYX A;  4PKG G;  4Z94 G;  5KYW B;  1D4X G;  2HD7 A;  2KVK A;  1EQY S;  2LJ8 A;  1SVY A;  3DA7 A;  1AK6 A;  3CI5 G;  1SVQ A;  3L50 A;  4LIZ A;  1COF A;  2LLF A;  1KCQ A;  1X67 A;  1ESV S;  1PD1 A;  1NLV G;  3EG9 B;  2VIK A;  3EFO A;  1YVN G;  2NUP B;  3EGX A;  2I2Q A;  3EGD B;  5KYU A;  1WFS A;  1NM1 G;  1PD0 A;  1PCX A;  1AHQ A;  4S10 C;  5KYX B;  1JHW A;  2D8B A;  1T44 G;  1SVR A;  2MV2 A;  1T3Y A;  2XFA A;  1DEJ S;  1VKK A;  3FFK A;  5KYY A;  1M2V A;  1VFQ A;  4KEF A;  4CBW G;  1UDM A;  3FG7 A;  2LXX A;  4JD2 H;  1HQZ 1;  1M4J A;  3CJB G;  3EFO B;  1WM4 A;  1T3X A;  3TU5 B;  3EGX B;  2FGH A;  1NMD G;  1C0G S;  3A5O S;  1H1V G;  5KYU B;  1QPV A;  5HVK B;  3Q2B A;  5A1M A;  2FH1 A;  5FAF A;  1P8X A;  4PKI G;  2NUT A;  3A5M S;  5KYN A;  5HVK D;  2FF3 A;  1Q8X A;  1Q8G A;  3EH2 A;  2MOT A;  4KED A;  1YAG G;  4CBX G;  1RGI G;  3DAW B;  3A5N S;  5KYY B;  1M2V B;  2FH2 A;  1MDU A;  1D0N A;  4KEE A;  2VIL A;  3EGD A;  2FH3 A;  2W0I A;  3FG6 A;  1TMW A;  1J72 A;  1C0F S;  2FF6 G;  1AK7 A;  5L6W C;  5KYW A;  2NUT B;  3FFN A;  2XF1 A;  2MP4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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