1XNZA

Crystal structure of mn(ii) form of e. coli. methionine aminopeptidase in complex with 5-(2-chlorophenyl)furan-2-carboxylic acid
Total Genus 90
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
90
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Metalloform-Selective Inhibitors of Escherichia coli Methionine Aminopeptidase and X-ray Structure of a Mn(II)-Form Enzyme Complexed with an Inhibitor.
pubmed doi rcsb
molecule keywords Methionine aminopeptidase
source organism Escherichia coli
molecule tags Hydrolase
total genus 90
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2004-10-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 1xnzA00
2BWTA 2GGCA 4IKSA 3FMRA 3PKAA 1QZYA 2GTXA 2EVOA 1C24A 1C27A 1YW7A 1XGOA 2BH3A 2V3XA 2IW2A 2Q93A 2GG0A 1C21A 1R5GA 2EA2A 3BIPA 4QR8A 1XGMA 1WL9A 2GU7A 4ZWUA 2GU5A 2GGBA 3CTZA 3TAVA 2V3ZA 1C22A 5CDVA 4ZNGA 3CB5A 1W7VA 2GG3A 2GG8A 5D6FA 2BHBA 2ZSGA 1WY2A 1KQ9A 4RGZ1 4S2TP 1YW8A 1PV9A 1WL6A 3PKEA 3IU7A 1WBQA 1M35A 2V3YA 2GG5A 2Q95A 2ADUA 3MX6A 1XNZA 4IDYA 5JI6A 3PKCA 4IU6A 4U70A 2Q96A 4U6ZA 1B6AA 4IKRA 2GA2A 2GG2A 2P98A 4MATA 1KP0A 4IPAA 4JUQA 4A6WA 3TB5A 2BWXA 5FCFA 2DFIA 2BWYA 4PV4A 1YJ3A 4RZZA 5CDLA 2B3LA 3MR1A 1WN1A 4IKUA 4ZWOA 2BB7A 3PKBA 4IF7A 4HXXA 2BHDA 1MATA 3D27A 4A6VA 2BHAA 4FLJA 4IECA 4U73A 2OAZA 2GU4A 3RORA 4U6WA 1WKMA 4U76A 2Q94A 4U6EA 2HOWA 2GZ5A 2NQ7A 3RVAA 4U6CA 1B59A 2EVMA 4FO7A 4EGEA 1YW9A 1BN5A 3BITA 2NQ6A 1Y1NA 1QXWA 2BWWA 3Q6DA 1KQ0A 2GG7A 3CB6A 3S6BA 3BIQA 4OOKA 4FLKA 5JHUA 1YVMA 2MATA 1QXYA 3FM3A 1R58A 4FLLA 1WLRA 2BWUA 4S00A 4ZWPA 1O0XA 3IG4A 4KM3A 5CLSA 2P99A 3FMQA 1QXZA 1XGNA 5CE6A 2GU6A 4PNCA 5JFRA 2GG9A 3IU8A 4U71A 4IKTA 4FLIA 2G6PA 2V6CA 4U1BA 5CNXA 4U75A 5FCHA 1CHMA 3L7GA 4S2RP 4FKCA 1N51A 4S01A 1C23A 3MATA 4U69A 4R60A 2B3HA 1A16A 2B3KA 4U6JA 5D6EA 5E5BA 1R5HA 2OKNA 1BOAA 1JAWA 5CIKA 2EVCA 2BN7A 2BHCA 2BWVA 3IU9A 4RZYA 4B28A 4Z7MA 2BWSA 2Q8KA 4FUKA 2EA4A 2P9AA 3L24A 1W2MA 2Q92A 4FO8A 3PKDA 1XGSA 5CDEA
chains in the Genus database with same CATH superfamily
2BWTA 2GGCA 4IKSA 3FMRA 3PKAA 1QZYA 2GTXA 2EVOA 1C24A 1C27A 1YW7A 1XGOA 2BH3A 2V3XA 2IW2A 2Q93A 2GG0A 1C21A 1R5GA 2EA2A 3BIPA 4QR8A 1XGMA 1WL9A 2GU7A 4ZWUA 2GU5A 2GGBA 3CTZA 3TAVA 2V3ZA 1C22A 5CDVA 4ZNGA 3CB5A 1W7VA 2GG3A 2GG8A 5D6FA 2BHBA 2ZSGA 1WY2A 1KQ9A 4RGZ1 4S2TP 1YW8A 1PV9A 1WL6A 3PKEA 3IU7A 1WBQA 1M35A 2V3YA 2GG5A 2Q95A 2ADUA 3MX6A 1XNZA 4IDYA 5JI6A 3PKCA 4IU6A 4U70A 2Q96A 4U6ZA 1B6AA 4IKRA 2GA2A 2GG2A 2P98A 4MATA 1KP0A 4IPAA 4JUQA 4A6WA 3TB5A 2BWXA 5FCFA 2DFIA 2BWYA 4PV4A 1YJ3A 4RZZA 5CDLA 2B3LA 3MR1A 1WN1A 4IKUA 4ZWOA 2BB7A 3PKBA 4IF7A 4HXXA 2BHDA 1MATA 3D27A 4A6VA 2BHAA 4FLJA 4IECA 4U73A 2OAZA 2GU4A 3RORA 4U6WA 1WKMA 4U76A 2Q94A 4U6EA 2HOWA 2GZ5A 2NQ7A 3RVAA 4U6CA 1B59A 2EVMA 4FO7A 4EGEA 1YW9A 1BN5A 3BITA 2NQ6A 1Y1NA 1QXWA 2BWWA 3Q6DA 1KQ0A 2GG7A 3CB6A 3S6BA 3BIQA 4OOKA 4FLKA 5JHUA 1YVMA 2MATA 1QXYA 3FM3A 1R58A 4FLLA 1WLRA 2BWUA 4S00A 4ZWPA 1O0XA 3IG4A 4KM3A 5CLSA 2P99A 3FMQA 1QXZA 1XGNA 5CE6A 2GU6A 4PNCA 5JFRA 2GG9A 3IU8A 4U71A 4IKTA 4FLIA 2G6PA 2V6CA 4U1BA 5CNXA 4U75A 5FCHA 1CHMA 3L7GA 4S2RP 4FKCA 1N51A 4S01A 1C23A 3MATA 4U69A 4R60A 2B3HA 1A16A 2B3KA 4U6JA 5D6EA 5E5BA 1R5HA 2OKNA 1BOAA 1JAWA 5CIKA 2EVCA 2BN7A 2BHCA 2BWVA 3IU9A 4RZYA 4B28A 4Z7MA 2BWSA 2Q8KA 4FUKA 2EA4A 2P9AA 3L24A 1W2MA 2Q92A 4FO8A 3PKDA 1XGSA 5CDEA
chains in the Genus database with same CATH topology
2BWTA 2GGCA 4IKSA 3FMRA 3PKAA 1QZYA 2GTXA 2EVOA 1C24A 1C27A 1YW7A 1XGOA 2BH3A 2V3XA 2IW2A 2Q93A 2GG0A 1C21A 1R5GA 2EA2A 3BIPA 4QR8A 1XGMA 1WL9A 2GU7A 4ZWUA 2GU5A 2GGBA 3CTZA 3TAVA 2V3ZA 1C22A 5CDVA 4ZNGA 3CB5A 1W7VA 2GG3A 2GG8A 5D6FA 2BHBA 2ZSGA 1WY2A 1KQ9A 4RGZ1 4S2TP 1YW8A 1PV9A 1WL6A 3PKEA 3IU7A 1WBQA 1M35A 2V3YA 2GG5A 2Q95A 2ADUA 3MX6A 1XNZA 4IDYA 5JI6A 3PKCA 4IU6A 4U70A 2Q96A 4U6ZA 1B6AA 4IKRA 2GA2A 2GG2A 2P98A 4MATA 1KP0A 4IPAA 4JUQA 4A6WA 3TB5A 2BWXA 5FCFA 2DFIA 2BWYA 4PV4A 1YJ3A 4RZZA 5CDLA 2B3LA 3MR1A 1WN1A 4IKUA 4ZWOA 2BB7A 3PKBA 4IF7A 4HXXA 2BHDA 1MATA 3D27A 4A6VA 2BHAA 4FLJA 4IECA 4U73A 2OAZA 2GU4A 3RORA 4U6WA 1WKMA 4U76A 2Q94A 4U6EA 2HOWA 2GZ5A 2NQ7A 3RVAA 4U6CA 1B59A 2EVMA 4FO7A 4EGEA 1YW9A 1BN5A 3BITA 2NQ6A 1Y1NA 1QXWA 2BWWA 3Q6DA 1KQ0A 2GG7A 3CB6A 3S6BA 3BIQA 4OOKA 4FLKA 5JHUA 1YVMA 2MATA 1QXYA 3FM3A 1R58A 4FLLA 1WLRA 2BWUA 4S00A 4ZWPA 1O0XA 3IG4A 4KM3A 5CLSA 2P99A 3FMQA 1QXZA 1XGNA 5CE6A 2GU6A 4PNCA 5JFRA 2GG9A 3IU8A 4U71A 4IKTA 4FLIA 2G6PA 2V6CA 4U1BA 5CNXA 4U75A 5FCHA 1CHMA 3L7GA 4S2RP 4FKCA 1N51A 4S01A 1C23A 3MATA 4U69A 4R60A 2B3HA 1A16A 2B3KA 4U6JA 5D6EA 5E5BA 1R5HA 2OKNA 1BOAA 1JAWA 5CIKA 2EVCA 2BN7A 2BHCA 2BWVA 3IU9A 4RZYA 4B28A 4Z7MA 2BWSA 2Q8KA 4FUKA 2EA4A 2P9AA 3L24A 1W2MA 2Q92A 4FO8A 3PKDA 1XGSA 5CDEA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2BWT A;  2GGC A;  4IKS A;  3FMR A;  3PKA A;  1QZY A;  2GTX A;  2EVO A;  1C24 A;  1C27 A;  1YW7 A;  1XGO A;  2BH3 A;  2V3X A;  2IW2 A;  2Q93 A;  2GG0 A;  1C21 A;  1R5G A;  2EA2 A;  3BIP A;  4QR8 A;  1XGM A;  1WL9 A;  2GU7 A;  4ZWU A;  2GU5 A;  2GGB A;  3CTZ A;  3TAV A;  2V3Z A;  1C22 A;  5CDV A;  4ZNG A;  3CB5 A;  1W7V A;  2GG3 A;  2GG8 A;  5D6F A;  2BHB A;  2ZSG A;  1WY2 A;  1KQ9 A;  4RGZ 1;  4S2T P;  1YW8 A;  1PV9 A;  1WL6 A;  3PKE A;  3IU7 A;  1WBQ A;  1M35 A;  2V3Y A;  2GG5 A;  2Q95 A;  2ADU A;  3MX6 A;  1XNZ A;  4IDY A;  5JI6 A;  3PKC A;  4IU6 A;  4U70 A;  2Q96 A;  4U6Z A;  1B6A A;  4IKR A;  2GA2 A;  2GG2 A;  2P98 A;  4MAT A;  1KP0 A;  4IPA A;  4JUQ A;  4A6W A;  3TB5 A;  2BWX A;  5FCF A;  2DFI A;  2BWY A;  4PV4 A;  1YJ3 A;  4RZZ A;  5CDL A;  2B3L A;  3MR1 A;  1WN1 A;  4IKU A;  4ZWO A;  2BB7 A;  3PKB A;  4IF7 A;  4HXX A;  2BHD A;  1MAT A;  3D27 A;  4A6V A;  2BHA A;  4FLJ A;  4IEC A;  4U73 A;  2OAZ A;  2GU4 A;  3ROR A;  4U6W A;  1WKM A;  4U76 A;  2Q94 A;  4U6E A;  2HOW A;  2GZ5 A;  2NQ7 A;  3RVA A;  4U6C A;  1B59 A;  2EVM A;  4FO7 A;  4EGE A;  1YW9 A;  1BN5 A;  3BIT A;  2NQ6 A;  1Y1N A;  1QXW A;  2BWW A;  3Q6D A;  1KQ0 A;  2GG7 A;  3CB6 A;  3S6B A;  3BIQ A;  4OOK A;  4FLK A;  5JHU A;  1YVM A;  2MAT A;  1QXY A;  3FM3 A;  1R58 A;  4FLL A;  1WLR A;  2BWU A;  4S00 A;  4ZWP A;  1O0X A;  3IG4 A;  4KM3 A;  5CLS A;  2P99 A;  3FMQ A;  1QXZ A;  1XGN A;  5CE6 A;  2GU6 A;  4PNC A;  5JFR A;  2GG9 A;  3IU8 A;  4U71 A;  4IKT A;  4FLI A;  2G6P A;  2V6C A;  4U1B A;  5CNX A;  4U75 A;  5FCH A;  1CHM A;  3L7G A;  4S2R P;  4FKC A;  1N51 A;  4S01 A;  1C23 A;  3MAT A;  4U69 A;  4R60 A;  2B3H A;  1A16 A;  2B3K A;  4U6J A;  5D6E A;  5E5B A;  1R5H A;  2OKN A;  1BOA A;  1JAW A;  5CIK A;  2EVC A;  2BN7 A;  2BHC A;  2BWV A;  3IU9 A;  4RZY A;  4B28 A;  4Z7M A;  2BWS A;  2Q8K A;  4FUK A;  2EA4 A;  2P9A A;  3L24 A;  1W2M A;  2Q92 A;  4FO8 A;  3PKD A;  1XGS A;  5CDE A; 
#chains in the Genus database with same CATH topology
 2BWT A;  2GGC A;  4IKS A;  3FMR A;  3PKA A;  1QZY A;  2GTX A;  2EVO A;  1C24 A;  1C27 A;  1YW7 A;  1XGO A;  2BH3 A;  2V3X A;  2IW2 A;  2Q93 A;  2GG0 A;  1C21 A;  1R5G A;  2EA2 A;  3BIP A;  4QR8 A;  1XGM A;  1WL9 A;  2GU7 A;  4ZWU A;  2GU5 A;  2GGB A;  3CTZ A;  3TAV A;  2V3Z A;  1C22 A;  5CDV A;  4ZNG A;  3CB5 A;  1W7V A;  2GG3 A;  2GG8 A;  5D6F A;  2BHB A;  2ZSG A;  1WY2 A;  1KQ9 A;  4RGZ 1;  4S2T P;  1YW8 A;  1PV9 A;  1WL6 A;  3PKE A;  3IU7 A;  1WBQ A;  1M35 A;  2V3Y A;  2GG5 A;  2Q95 A;  2ADU A;  3MX6 A;  1XNZ A;  4IDY A;  5JI6 A;  3PKC A;  4IU6 A;  4U70 A;  2Q96 A;  4U6Z A;  1B6A A;  4IKR A;  2GA2 A;  2GG2 A;  2P98 A;  4MAT A;  1KP0 A;  4IPA A;  4JUQ A;  4A6W A;  3TB5 A;  2BWX A;  5FCF A;  2DFI A;  2BWY A;  4PV4 A;  1YJ3 A;  4RZZ A;  5CDL A;  2B3L A;  3MR1 A;  1WN1 A;  4IKU A;  4ZWO A;  2BB7 A;  3PKB A;  4IF7 A;  4HXX A;  2BHD A;  1MAT A;  3D27 A;  4A6V A;  2BHA A;  4FLJ A;  4IEC A;  4U73 A;  2OAZ A;  2GU4 A;  3ROR A;  4U6W A;  1WKM A;  4U76 A;  2Q94 A;  4U6E A;  2HOW A;  2GZ5 A;  2NQ7 A;  3RVA A;  4U6C A;  1B59 A;  2EVM A;  4FO7 A;  4EGE A;  1YW9 A;  1BN5 A;  3BIT A;  2NQ6 A;  1Y1N A;  1QXW A;  2BWW A;  3Q6D A;  1KQ0 A;  2GG7 A;  3CB6 A;  3S6B A;  3BIQ A;  4OOK A;  4FLK A;  5JHU A;  1YVM A;  2MAT A;  1QXY A;  3FM3 A;  1R58 A;  4FLL A;  1WLR A;  2BWU A;  4S00 A;  4ZWP A;  1O0X A;  3IG4 A;  4KM3 A;  5CLS A;  2P99 A;  3FMQ A;  1QXZ A;  1XGN A;  5CE6 A;  2GU6 A;  4PNC A;  5JFR A;  2GG9 A;  3IU8 A;  4U71 A;  4IKT A;  4FLI A;  2G6P A;  2V6C A;  4U1B A;  5CNX A;  4U75 A;  5FCH A;  1CHM A;  3L7G A;  4S2R P;  4FKC A;  1N51 A;  4S01 A;  1C23 A;  3MAT A;  4U69 A;  4R60 A;  2B3H A;  1A16 A;  2B3K A;  4U6J A;  5D6E A;  5E5B A;  1R5H A;  2OKN A;  1BOA A;  1JAW A;  5CIK A;  2EVC A;  2BN7 A;  2BHC A;  2BWV A;  3IU9 A;  4RZY A;  4B28 A;  4Z7M A;  2BWS A;  2Q8K A;  4FUK A;  2EA4 A;  2P9A A;  3L24 A;  1W2M A;  2Q92 A;  4FO8 A;  3PKD A;  1XGS A;  5CDE A; 
#chains in the Genus database with same CATH homology
 2BWT A;  2GGC A;  4IKS A;  3FMR A;  3PKA A;  1QZY A;  2GTX A;  2EVO A;  1C24 A;  1C27 A;  1YW7 A;  1XGO A;  2BH3 A;  2V3X A;  2IW2 A;  2Q93 A;  2GG0 A;  1C21 A;  1R5G A;  2EA2 A;  3BIP A;  4QR8 A;  1XGM A;  1WL9 A;  2GU7 A;  4ZWU A;  2GU5 A;  2GGB A;  3CTZ A;  3TAV A;  2V3Z A;  1C22 A;  5CDV A;  4ZNG A;  3CB5 A;  1W7V A;  2GG3 A;  2GG8 A;  5D6F A;  2BHB A;  2ZSG A;  1WY2 A;  1KQ9 A;  4RGZ 1;  4S2T P;  1YW8 A;  1PV9 A;  1WL6 A;  3PKE A;  3IU7 A;  1WBQ A;  1M35 A;  2V3Y A;  2GG5 A;  2Q95 A;  2ADU A;  3MX6 A;  1XNZ A;  4IDY A;  5JI6 A;  3PKC A;  4IU6 A;  4U70 A;  2Q96 A;  4U6Z A;  1B6A A;  4IKR A;  2GA2 A;  2GG2 A;  2P98 A;  4MAT A;  1KP0 A;  4IPA A;  4JUQ A;  4A6W A;  3TB5 A;  2BWX A;  5FCF A;  2DFI A;  2BWY A;  4PV4 A;  1YJ3 A;  4RZZ A;  5CDL A;  2B3L A;  3MR1 A;  1WN1 A;  4IKU A;  4ZWO A;  2BB7 A;  3PKB A;  4IF7 A;  4HXX A;  2BHD A;  1MAT A;  3D27 A;  4A6V A;  2BHA A;  4FLJ A;  4IEC A;  4U73 A;  2OAZ A;  2GU4 A;  3ROR A;  4U6W A;  1WKM A;  4U76 A;  2Q94 A;  4U6E A;  2HOW A;  2GZ5 A;  2NQ7 A;  3RVA A;  4U6C A;  1B59 A;  2EVM A;  4FO7 A;  4EGE A;  1YW9 A;  1BN5 A;  3BIT A;  2NQ6 A;  1Y1N A;  1QXW A;  2BWW A;  3Q6D A;  1KQ0 A;  2GG7 A;  3CB6 A;  3S6B A;  3BIQ A;  4OOK A;  4FLK A;  5JHU A;  1YVM A;  2MAT A;  1QXY A;  3FM3 A;  1R58 A;  4FLL A;  1WLR A;  2BWU A;  4S00 A;  4ZWP A;  1O0X A;  3IG4 A;  4KM3 A;  5CLS A;  2P99 A;  3FMQ A;  1QXZ A;  1XGN A;  5CE6 A;  2GU6 A;  4PNC A;  5JFR A;  2GG9 A;  3IU8 A;  4U71 A;  4IKT A;  4FLI A;  2G6P A;  2V6C A;  4U1B A;  5CNX A;  4U75 A;  5FCH A;  1CHM A;  3L7G A;  4S2R P;  4FKC A;  1N51 A;  4S01 A;  1C23 A;  3MAT A;  4U69 A;  4R60 A;  2B3H A;  1A16 A;  2B3K A;  4U6J A;  5D6E A;  5E5B A;  1R5H A;  2OKN A;  1BOA A;  1JAW A;  5CIK A;  2EVC A;  2BN7 A;  2BHC A;  2BWV A;  3IU9 A;  4RZY A;  4B28 A;  4Z7M A;  2BWS A;  2Q8K A;  4FUK A;  2EA4 A;  2P9A A;  3L24 A;  1W2M A;  2Q92 A;  4FO8 A;  3PKD A;  1XGS A;  5CDE A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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