1Y1NA

Identification of sh3 motif in m. tuberculosis methionine aminopeptidase suggests a mode of interaction with the ribosome
Total Genus 86
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
282
structure length
282
Chain Sequence
RTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTCL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Methionine aminopeptidase 1B
publication title Identification of an SH3-Binding Motif in a New Class of Methionine Aminopeptidases from Mycobacterium tuberculosis Suggests a Mode of Interaction with the Ribosome
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Hydrolase
total genus 86
structure length 282
sequence length 282
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2004-11-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 1y1nA01
1QZYA 2BWWA 2EVOA 4B28A 4FLLA 2Q94A 1XGMA 1YW9A 2GG0A 2BH3A 1WY2A 3PKAA 1QXWA 3MR1A 1BN5A 4RGZ1 3PKCA 3CB5A 4QR8A 3BITA 5CE6A 2BWTA 4ZWUA 1QXYA 1WBQA 4FLKA 2V3XA 4FUKA 4U70A 5FCFA 4A6VA 4U69A 1WL9A 5CNXA 1XGSA 1N51A 2BHBA 1WL6A 4U73A 2V6CA 3PKDA 4IDYA 4PNCA 2ZSGA 4FO8A 2GA2A 2P99A 5CDVA 2GTXA 3IG4A 2B3LA 4HXXA 2BB7A 2BHAA 2Q92A 1C27A 3RORA 4ZWPA 4S01A 5CDEA 2Q96A 1KQ9A 4FLIA 2B3KA 5D6EA 2NQ6A 3IU7A 2EA4A 4IKRA 1R5GA 1PV9A 2BWVA 5FCHA 2IW2A 4U6JA 4IU6A 2P9AA 2V3ZA 4JUQA 1XGOA 1B59A 1Y1NA 2NQ7A 1KP0A 1C21A 1W7VA 4FKCA 4S00A 3L24A 2BN7A 4RZYA 3D27A 4A6WA 1A16A 2Q93A 1B6AA 2GG7A 1WKMA 2OKNA 4U71A 3MATA 4KM3A 1R58A 2Q95A 1KQ0A 3FM3A 4MATA 1W2MA 1C24A 2GG2A 3CB6A 2V3YA 5CIKA 4Z7MA 1WLRA 2ADUA 2GU6A 2BHDA 1YW7A 4R60A 4U6EA 4FO7A 4ZNGA 2DFIA 1R5HA 2EA2A 5JI6A 2GG5A 2P98A 2GGBA 2Q8KA 4OOKA 3IU8A 1JAWA 2GU7A 2GG3A 4U6CA 3L7GA 1C22A 3RVAA 4IF7A 2HOWA 1O0XA 3FMQA 3FMRA 3TB5A 5JHUA 5D6FA 2GU4A 2GGCA 5JFRA 3Q6DA 4FLJA 2EVMA 1BOAA 4PV4A 1XGNA 3PKEA 3MX6A 4U6ZA 1CHMA 4IKTA 4U75A 5E5BA 1YJ3A 2BWUA 3BIQA 3TAVA 1YVMA 4U6WA 2G6PA 2GG9A 1M35A 5CLSA 2BHCA 2EVCA 4IKSA 2BWXA 1WN1A 4S2TP 2B3HA 4EGEA 5CDLA 2GG8A 2OAZA 1XNZA 1YW8A 2BWSA 3CTZA 3PKBA 4IKUA 4IPAA 4U1BA 3BIPA 3S6BA 2MATA 1QXZA 4S2RP 2GZ5A 4RZZA 4ZWOA 3IU9A 1MATA 4U76A 4IECA 2BWYA 2GU5A 1C23A
chains in the Genus database with same CATH superfamily
1QZYA 2BWWA 2EVOA 4B28A 4FLLA 2Q94A 1XGMA 1YW9A 2GG0A 2BH3A 1WY2A 3PKAA 1QXWA 3MR1A 1BN5A 4RGZ1 3PKCA 3CB5A 4QR8A 3BITA 5CE6A 2BWTA 4ZWUA 1QXYA 1WBQA 4FLKA 2V3XA 4FUKA 4U70A 5FCFA 4A6VA 4U69A 1WL9A 5CNXA 1XGSA 1N51A 2BHBA 1WL6A 4U73A 2V6CA 3PKDA 4IDYA 4PNCA 2ZSGA 4FO8A 2GA2A 2P99A 5CDVA 2GTXA 3IG4A 2B3LA 4HXXA 2BB7A 2BHAA 2Q92A 1C27A 3RORA 4ZWPA 4S01A 5CDEA 2Q96A 1KQ9A 4FLIA 2B3KA 5D6EA 2NQ6A 3IU7A 2EA4A 4IKRA 1R5GA 1PV9A 2BWVA 5FCHA 2IW2A 4U6JA 4IU6A 2P9AA 2V3ZA 4JUQA 1XGOA 1B59A 1Y1NA 2NQ7A 1KP0A 1C21A 1W7VA 4FKCA 4S00A 3L24A 2BN7A 4RZYA 3D27A 4A6WA 1A16A 2Q93A 1B6AA 2GG7A 1WKMA 2OKNA 4U71A 3MATA 4KM3A 1R58A 2Q95A 1KQ0A 3FM3A 4MATA 1W2MA 1C24A 2GG2A 3CB6A 2V3YA 5CIKA 4Z7MA 1WLRA 2ADUA 2GU6A 2BHDA 1YW7A 4R60A 4U6EA 4FO7A 4ZNGA 2DFIA 1R5HA 2EA2A 5JI6A 2GG5A 2P98A 2GGBA 2Q8KA 4OOKA 3IU8A 1JAWA 2GU7A 2GG3A 4U6CA 3L7GA 1C22A 3RVAA 4IF7A 2HOWA 1O0XA 3FMQA 3FMRA 3TB5A 5JHUA 5D6FA 2GU4A 2GGCA 5JFRA 3Q6DA 4FLJA 2EVMA 1BOAA 4PV4A 1XGNA 3PKEA 3MX6A 4U6ZA 1CHMA 4IKTA 4U75A 5E5BA 1YJ3A 2BWUA 3BIQA 3TAVA 1YVMA 4U6WA 2G6PA 2GG9A 1M35A 5CLSA 2BHCA 2EVCA 4IKSA 2BWXA 1WN1A 4S2TP 2B3HA 4EGEA 5CDLA 2GG8A 2OAZA 1XNZA 1YW8A 2BWSA 3CTZA 3PKBA 4IKUA 4IPAA 4U1BA 3BIPA 3S6BA 2MATA 1QXZA 4S2RP 2GZ5A 4RZZA 4ZWOA 3IU9A 1MATA 4U76A 4IECA 2BWYA 2GU5A 1C23A
chains in the Genus database with same CATH topology
1QZYA 2BWWA 2EVOA 4B28A 4FLLA 2Q94A 1XGMA 1YW9A 2GG0A 2BH3A 1WY2A 3PKAA 1QXWA 3MR1A 1BN5A 4RGZ1 3PKCA 3CB5A 4QR8A 3BITA 5CE6A 2BWTA 4ZWUA 1QXYA 1WBQA 4FLKA 2V3XA 4FUKA 4U70A 5FCFA 4A6VA 4U69A 1WL9A 5CNXA 1XGSA 1N51A 2BHBA 1WL6A 4U73A 2V6CA 3PKDA 4IDYA 4PNCA 2ZSGA 4FO8A 2GA2A 2P99A 5CDVA 2GTXA 3IG4A 2B3LA 4HXXA 2BB7A 2BHAA 2Q92A 1C27A 3RORA 4ZWPA 4S01A 5CDEA 2Q96A 1KQ9A 4FLIA 2B3KA 5D6EA 2NQ6A 3IU7A 2EA4A 4IKRA 1R5GA 1PV9A 2BWVA 5FCHA 2IW2A 4U6JA 4IU6A 2P9AA 2V3ZA 4JUQA 1XGOA 1B59A 1Y1NA 2NQ7A 1KP0A 1C21A 1W7VA 4FKCA 4S00A 3L24A 2BN7A 4RZYA 3D27A 4A6WA 1A16A 2Q93A 1B6AA 2GG7A 1WKMA 2OKNA 4U71A 3MATA 4KM3A 1R58A 2Q95A 1KQ0A 3FM3A 4MATA 1W2MA 1C24A 2GG2A 3CB6A 2V3YA 5CIKA 4Z7MA 1WLRA 2ADUA 2GU6A 2BHDA 1YW7A 4R60A 4U6EA 4FO7A 4ZNGA 2DFIA 1R5HA 2EA2A 5JI6A 2GG5A 2P98A 2GGBA 2Q8KA 4OOKA 3IU8A 1JAWA 2GU7A 2GG3A 4U6CA 3L7GA 1C22A 3RVAA 4IF7A 2HOWA 1O0XA 3FMQA 3FMRA 3TB5A 5JHUA 5D6FA 2GU4A 2GGCA 5JFRA 3Q6DA 4FLJA 2EVMA 1BOAA 4PV4A 1XGNA 3PKEA 3MX6A 4U6ZA 1CHMA 4IKTA 4U75A 5E5BA 1YJ3A 2BWUA 3BIQA 3TAVA 1YVMA 4U6WA 2G6PA 2GG9A 1M35A 5CLSA 2BHCA 2EVCA 4IKSA 2BWXA 1WN1A 4S2TP 2B3HA 4EGEA 5CDLA 2GG8A 2OAZA 1XNZA 1YW8A 2BWSA 3CTZA 3PKBA 4IKUA 4IPAA 4U1BA 3BIPA 3S6BA 2MATA 1QXZA 4S2RP 2GZ5A 4RZZA 4ZWOA 3IU9A 1MATA 4U76A 4IECA 2BWYA 2GU5A 1C23A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1QZY A;  2BWW A;  2EVO A;  4B28 A;  4FLL A;  2Q94 A;  1XGM A;  1YW9 A;  2GG0 A;  2BH3 A;  1WY2 A;  3PKA A;  1QXW A;  3MR1 A;  1BN5 A;  4RGZ 1;  3PKC A;  3CB5 A;  4QR8 A;  3BIT A;  5CE6 A;  2BWT A;  4ZWU A;  1QXY A;  1WBQ A;  4FLK A;  2V3X A;  4FUK A;  4U70 A;  5FCF A;  4A6V A;  4U69 A;  1WL9 A;  5CNX A;  1XGS A;  1N51 A;  2BHB A;  1WL6 A;  4U73 A;  2V6C A;  3PKD A;  4IDY A;  4PNC A;  2ZSG A;  4FO8 A;  2GA2 A;  2P99 A;  5CDV A;  2GTX A;  3IG4 A;  2B3L A;  4HXX A;  2BB7 A;  2BHA A;  2Q92 A;  1C27 A;  3ROR A;  4ZWP A;  4S01 A;  5CDE A;  2Q96 A;  1KQ9 A;  4FLI A;  2B3K A;  5D6E A;  2NQ6 A;  3IU7 A;  2EA4 A;  4IKR A;  1R5G A;  1PV9 A;  2BWV A;  5FCH A;  2IW2 A;  4U6J A;  4IU6 A;  2P9A A;  2V3Z A;  4JUQ A;  1XGO A;  1B59 A;  1Y1N A;  2NQ7 A;  1KP0 A;  1C21 A;  1W7V A;  4FKC A;  4S00 A;  3L24 A;  2BN7 A;  4RZY A;  3D27 A;  4A6W A;  1A16 A;  2Q93 A;  1B6A A;  2GG7 A;  1WKM A;  2OKN A;  4U71 A;  3MAT A;  4KM3 A;  1R58 A;  2Q95 A;  1KQ0 A;  3FM3 A;  4MAT A;  1W2M A;  1C24 A;  2GG2 A;  3CB6 A;  2V3Y A;  5CIK A;  4Z7M A;  1WLR A;  2ADU A;  2GU6 A;  2BHD A;  1YW7 A;  4R60 A;  4U6E A;  4FO7 A;  4ZNG A;  2DFI A;  1R5H A;  2EA2 A;  5JI6 A;  2GG5 A;  2P98 A;  2GGB A;  2Q8K A;  4OOK A;  3IU8 A;  1JAW A;  2GU7 A;  2GG3 A;  4U6C A;  3L7G A;  1C22 A;  3RVA A;  4IF7 A;  2HOW A;  1O0X A;  3FMQ A;  3FMR A;  3TB5 A;  5JHU A;  5D6F A;  2GU4 A;  2GGC A;  5JFR A;  3Q6D A;  4FLJ A;  2EVM A;  1BOA A;  4PV4 A;  1XGN A;  3PKE A;  3MX6 A;  4U6Z A;  1CHM A;  4IKT A;  4U75 A;  5E5B A;  1YJ3 A;  2BWU A;  3BIQ A;  3TAV A;  1YVM A;  4U6W A;  2G6P A;  2GG9 A;  1M35 A;  5CLS A;  2BHC A;  2EVC A;  4IKS A;  2BWX A;  1WN1 A;  4S2T P;  2B3H A;  4EGE A;  5CDL A;  2GG8 A;  2OAZ A;  1XNZ A;  1YW8 A;  2BWS A;  3CTZ A;  3PKB A;  4IKU A;  4IPA A;  4U1B A;  3BIP A;  3S6B A;  2MAT A;  1QXZ A;  4S2R P;  2GZ5 A;  4RZZ A;  4ZWO A;  3IU9 A;  1MAT A;  4U76 A;  4IEC A;  2BWY A;  2GU5 A;  1C23 A; 
#chains in the Genus database with same CATH topology
 1QZY A;  2BWW A;  2EVO A;  4B28 A;  4FLL A;  2Q94 A;  1XGM A;  1YW9 A;  2GG0 A;  2BH3 A;  1WY2 A;  3PKA A;  1QXW A;  3MR1 A;  1BN5 A;  4RGZ 1;  3PKC A;  3CB5 A;  4QR8 A;  3BIT A;  5CE6 A;  2BWT A;  4ZWU A;  1QXY A;  1WBQ A;  4FLK A;  2V3X A;  4FUK A;  4U70 A;  5FCF A;  4A6V A;  4U69 A;  1WL9 A;  5CNX A;  1XGS A;  1N51 A;  2BHB A;  1WL6 A;  4U73 A;  2V6C A;  3PKD A;  4IDY A;  4PNC A;  2ZSG A;  4FO8 A;  2GA2 A;  2P99 A;  5CDV A;  2GTX A;  3IG4 A;  2B3L A;  4HXX A;  2BB7 A;  2BHA A;  2Q92 A;  1C27 A;  3ROR A;  4ZWP A;  4S01 A;  5CDE A;  2Q96 A;  1KQ9 A;  4FLI A;  2B3K A;  5D6E A;  2NQ6 A;  3IU7 A;  2EA4 A;  4IKR A;  1R5G A;  1PV9 A;  2BWV A;  5FCH A;  2IW2 A;  4U6J A;  4IU6 A;  2P9A A;  2V3Z A;  4JUQ A;  1XGO A;  1B59 A;  1Y1N A;  2NQ7 A;  1KP0 A;  1C21 A;  1W7V A;  4FKC A;  4S00 A;  3L24 A;  2BN7 A;  4RZY A;  3D27 A;  4A6W A;  1A16 A;  2Q93 A;  1B6A A;  2GG7 A;  1WKM A;  2OKN A;  4U71 A;  3MAT A;  4KM3 A;  1R58 A;  2Q95 A;  1KQ0 A;  3FM3 A;  4MAT A;  1W2M A;  1C24 A;  2GG2 A;  3CB6 A;  2V3Y A;  5CIK A;  4Z7M A;  1WLR A;  2ADU A;  2GU6 A;  2BHD A;  1YW7 A;  4R60 A;  4U6E A;  4FO7 A;  4ZNG A;  2DFI A;  1R5H A;  2EA2 A;  5JI6 A;  2GG5 A;  2P98 A;  2GGB A;  2Q8K A;  4OOK A;  3IU8 A;  1JAW A;  2GU7 A;  2GG3 A;  4U6C A;  3L7G A;  1C22 A;  3RVA A;  4IF7 A;  2HOW A;  1O0X A;  3FMQ A;  3FMR A;  3TB5 A;  5JHU A;  5D6F A;  2GU4 A;  2GGC A;  5JFR A;  3Q6D A;  4FLJ A;  2EVM A;  1BOA A;  4PV4 A;  1XGN A;  3PKE A;  3MX6 A;  4U6Z A;  1CHM A;  4IKT A;  4U75 A;  5E5B A;  1YJ3 A;  2BWU A;  3BIQ A;  3TAV A;  1YVM A;  4U6W A;  2G6P A;  2GG9 A;  1M35 A;  5CLS A;  2BHC A;  2EVC A;  4IKS A;  2BWX A;  1WN1 A;  4S2T P;  2B3H A;  4EGE A;  5CDL A;  2GG8 A;  2OAZ A;  1XNZ A;  1YW8 A;  2BWS A;  3CTZ A;  3PKB A;  4IKU A;  4IPA A;  4U1B A;  3BIP A;  3S6B A;  2MAT A;  1QXZ A;  4S2R P;  2GZ5 A;  4RZZ A;  4ZWO A;  3IU9 A;  1MAT A;  4U76 A;  4IEC A;  2BWY A;  2GU5 A;  1C23 A; 
#chains in the Genus database with same CATH homology
 1QZY A;  2BWW A;  2EVO A;  4B28 A;  4FLL A;  2Q94 A;  1XGM A;  1YW9 A;  2GG0 A;  2BH3 A;  1WY2 A;  3PKA A;  1QXW A;  3MR1 A;  1BN5 A;  4RGZ 1;  3PKC A;  3CB5 A;  4QR8 A;  3BIT A;  5CE6 A;  2BWT A;  4ZWU A;  1QXY A;  1WBQ A;  4FLK A;  2V3X A;  4FUK A;  4U70 A;  5FCF A;  4A6V A;  4U69 A;  1WL9 A;  5CNX A;  1XGS A;  1N51 A;  2BHB A;  1WL6 A;  4U73 A;  2V6C A;  3PKD A;  4IDY A;  4PNC A;  2ZSG A;  4FO8 A;  2GA2 A;  2P99 A;  5CDV A;  2GTX A;  3IG4 A;  2B3L A;  4HXX A;  2BB7 A;  2BHA A;  2Q92 A;  1C27 A;  3ROR A;  4ZWP A;  4S01 A;  5CDE A;  2Q96 A;  1KQ9 A;  4FLI A;  2B3K A;  5D6E A;  2NQ6 A;  3IU7 A;  2EA4 A;  4IKR A;  1R5G A;  1PV9 A;  2BWV A;  5FCH A;  2IW2 A;  4U6J A;  4IU6 A;  2P9A A;  2V3Z A;  4JUQ A;  1XGO A;  1B59 A;  1Y1N A;  2NQ7 A;  1KP0 A;  1C21 A;  1W7V A;  4FKC A;  4S00 A;  3L24 A;  2BN7 A;  4RZY A;  3D27 A;  4A6W A;  1A16 A;  2Q93 A;  1B6A A;  2GG7 A;  1WKM A;  2OKN A;  4U71 A;  3MAT A;  4KM3 A;  1R58 A;  2Q95 A;  1KQ0 A;  3FM3 A;  4MAT A;  1W2M A;  1C24 A;  2GG2 A;  3CB6 A;  2V3Y A;  5CIK A;  4Z7M A;  1WLR A;  2ADU A;  2GU6 A;  2BHD A;  1YW7 A;  4R60 A;  4U6E A;  4FO7 A;  4ZNG A;  2DFI A;  1R5H A;  2EA2 A;  5JI6 A;  2GG5 A;  2P98 A;  2GGB A;  2Q8K A;  4OOK A;  3IU8 A;  1JAW A;  2GU7 A;  2GG3 A;  4U6C A;  3L7G A;  1C22 A;  3RVA A;  4IF7 A;  2HOW A;  1O0X A;  3FMQ A;  3FMR A;  3TB5 A;  5JHU A;  5D6F A;  2GU4 A;  2GGC A;  5JFR A;  3Q6D A;  4FLJ A;  2EVM A;  1BOA A;  4PV4 A;  1XGN A;  3PKE A;  3MX6 A;  4U6Z A;  1CHM A;  4IKT A;  4U75 A;  5E5B A;  1YJ3 A;  2BWU A;  3BIQ A;  3TAV A;  1YVM A;  4U6W A;  2G6P A;  2GG9 A;  1M35 A;  5CLS A;  2BHC A;  2EVC A;  4IKS A;  2BWX A;  1WN1 A;  4S2T P;  2B3H A;  4EGE A;  5CDL A;  2GG8 A;  2OAZ A;  1XNZ A;  1YW8 A;  2BWS A;  3CTZ A;  3PKB A;  4IKU A;  4IPA A;  4U1B A;  3BIP A;  3S6B A;  2MAT A;  1QXZ A;  4S2R P;  2GZ5 A;  4RZZ A;  4ZWO A;  3IU9 A;  1MAT A;  4U76 A;  4IEC A;  2BWY A;  2GU5 A;  1C23 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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