1Y2MA

Crystal structure of phenylalanine ammonia-lyase from yeast rhododporidium toruloides
Total Genus 244
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
244
sequence length
690
structure length
665
Chain Sequence
ASTNLAVAGSHLPTTQVTQVDIVEKMLAAPTDSTLELDGYSLNLGDVVSAARKGRPVRVKDSDEIRSKIDKSVEFLRTEDAISLQKALLEHQLCGVLPSSFDSFRLGRGLENSLPLEVVRGAMTIRVNSLTRGHSAVRLVVLEALTNFLNHGITPIVPLRGTISASGDLSPLSYIAAAISGHPDSKVHVVHEGKEKILYAREAMALFNLEPVVLGPKEGLGLVNGTAVSASMATLALHDAHMLSLLSQSLTAMTVEAMVGHAGSFHPFLHDVTRPHPTQIEVAGNIRKLLEGSRFAVHHEEEVDEGILRQDRYPLRTSPQWLGPLVSDLIHAHAVLTIEAGQSTTDNPLIDVENKTSHHGGNFQAAAVANTMEKTRLGLAQIGKLNFTQLTEMLNAGMNRGLPSCLAAEDPSLSYHCKGLDIAAAAYTSELGHLANPVTTHVQPAEMANQAVNSLALISARRTTESNDVLSLLLATHLYCVLQAIDLRAIEFEFKKQFGPAIVSLIDQHFGSAMTGSNLRDELVEKVNKTLAKRLEQTNSYDLVPRWHDAFSFAAGTVVEVLSSTSLSLAAVNAWKVAAAESAISLTRQVRETFWSAASTSSPALSYLSPRTQILYAFVREELGVKARRGDVFLGKQEVTIGSNVSKIYEAIKSGRINNVLLKML
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure-based chemical modification strategy for enzyme replacement treatment of phenylketonuria.
pubmed doi rcsb
source organism Rhodosporidium toruloides
molecule tags Lyase
molecule keywords Phenylalanine ammonia-lyase
total genus 244
structure length 665
sequence length 690
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.25: Phenylalanine/tyrosine ammonia-lyase.
pdb deposition date 2004-11-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 1y2mA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1y2mA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1y2mA02
2X75A 2RJRA 1HY1A 4MX2A 1T6JA 2O7BA 4FFXA 1W27A 4C6GA 4C5SA 2RJSA 3R6YA 1TJVA 4ADLA 2YIIA 2FUSA 1J3UA 1FURA 1GK2A 1FUOA 4BABA 2HVGA 1VDKA 3GZHA 4BAAA 1AUWA 1Y2MA 1DOFA 4C5RA 1GK3A 3RRPA 3CZOA 1EB4A 1FUQA 1YFEA 5EYVA 3TV2A 5F92A 4APBA 1YFMA 4NLEA 2PFMA 4ADMA 4EFCA 1GKJA 5HW2A 1U16A 1HY0A 1K62A 2O78A 3NZ4A 4FLCA 4V2QA 1U15A 2OHYA 4HGVA 1TJ7A 1T6PA 5D6BA 1JSWA 1KQ7A 2E9FA 3OCFA 3QBPA 2NYFA 2O6YA 3OCEA 2NYNA 3RD8A 1B8FA 4NSLA 3UNVA 2O7FA 3KDYA 4CQ5A 1DCNA 3C8TA 4APAA 2QVEA 1Q5NA 4V2RA 5EYTA 1TJUA 1TJWA 3E04A 3NO9A 3R6VA 2PTSA 1RE5A 2QGAB 1I0AA 1C3CA 1K7WA 1XWOA 1GKMA 1C3UA 2O7DA 1YISA 2O7EA 3R6QA 3GTDA 2PTQA 2PTRA 2VD6A 1FUPA 3KDZA 4C5UA 2J91A 4EEIA 3BHGA 5F91A
chains in the Genus database with same CATH superfamily
2X75A 2RJRA 2A69D 1HY1A 1WCMA 4MX2A 2JA7A 1T6JA 2O7BA 4FFXA 2FELA 1W27A 1R9TA 2B63A 4C6GA 4C5SA 2RJSA 3R6YA 1TJVA 3FKIA 2E2IA 4ADLA 2YIIA 2FUSA 3CRW1 2EZAA 4A15A 3LRDA 4FBSA 1I6VD 1J3UA 1XL8A 3EZBA 1I3QA 2VK9A 3GTLA 2LTHA 1TWFA 1FURA 3EZAA 1I50A 1GK2A 2N3EA 2LPJA 1FUOA 2NVYA 2MP0A 2JA5A 4BABA 1HQMD 1XLYA 2HVGA 1VDKA 3GZHA 4BAAA 3GTJA 1AUWA 4WNLA 1Y2MA 1DOFA 4C5RA 1GK3A 3RRPA 3CZOA 1EB4A 1EZAA 1FUQA 2X0PA 1YFEA 5EYVA 3TV2A 4APBA 5F92A 2HWGA 1YFMA 2PFMA 4NLEA 4ADMA 4EFCA 2VUMA 1TWHA 1GKJA 3GTQA 3GTGA 2JA6A 1XMDA 5HW2A 2AQLA 1U16A 2A6ED 3GTKA 1HY0A 1K62A 5H8WA 2N1DB 2X0OA 3NZ4A 2O78A 2FENA 4FLCA 2A68D 2K3OA 4V2QA 1K83A 1U15A 2OHYA 4HGVA 3EZEA 1IW7D 2K3NA 1T6PA 2E2HA 1TJ7A 3BHGA 3U44A 1SFOA 1JSWA 2FIPA 2R7ZA 1XL7A 1KQ7A 5D6BA 2E9FA 2LPIA 3GTPA 3OCFA 3QBPA 2NYFA 5M0IA 1SMYD 2O6YA 5M0JA 3OCEA 4C2MA 2FIOA 2YU9A 2NYNA 3RD8A 4CEJA 1B8FA 4NSLA 3UNVA 1TWAA 2LYIA 2O7FA 1Y1WA 3KDYA 4CQ5A 1DCNA 5IZ2A 3C8TA 2LKMB 2A6HD 2QVEA 2VSFA 1YNJD 4APAA 1TWCA 1Q5NA 4V2RA 4CEIA 5EYTA 3GTOA 1EZBA 2R93A 3LR6A 1TJUA 1TJWA 3E04A 3NO9A 4QIWA 3R6VA 2EZBA 2PTSA 1RE5A 2QGAB 2NVXA 2CW0D 1ZYRD 2BE5D 2O5JD 1I0AA 2F5JA 1C3CA 2VL7A 1K7WA 1XWOA 3CRVA 1GKMA 1C3UA 2K3QA 1TWGA 3LR2A 2R92A 2MX8A 1YISA 2MQAA 2O7DA 1ZYMA 2O7EA 3R6QA 2MX9A 3GTDA 2EZCA 2PTQA 2PTRA 2HROA 2VD6A 1FUPA 3KDZA 1XMCA 2X0QA 2Y0NA 1Y1VA 4CEHA 4C5UA 3CQZA 2J91A 4EEIA 3GTMA 3U4QA 1YNND 3H0GA 5F91A 3LR8A
chains in the Genus database with same CATH topology
2X75A 2RJRA 1HY1A 4MX2A 1T6JA 2O7BA 4FFXA 1W27A 4C6GA 4C5SA 2RJSA 3R6YA 1TJVA 4ADLA 2YIIA 2FUSA 1J3UA 1FURA 1GK2A 1FUOA 4BABA 2HVGA 1VDKA 3GZHA 4BAAA 1AUWA 1Y2MA 1DOFA 4C5RA 1GK3A 3RRPA 3CZOA 1EB4A 1FUQA 1YFEA 5EYVA 3TV2A 5F92A 4APBA 1YFMA 4NLEA 2PFMA 4ADMA 4EFCA 1GKJA 5HW2A 1U16A 1HY0A 1K62A 2O78A 3NZ4A 4FLCA 4V2QA 1U15A 2OHYA 4HGVA 1TJ7A 1T6PA 5D6BA 1JSWA 1KQ7A 2E9FA 3OCFA 3QBPA 2NYFA 2O6YA 3OCEA 2NYNA 3RD8A 1B8FA 4NSLA 3UNVA 2O7FA 3KDYA 4CQ5A 1DCNA 3C8TA 4APAA 2QVEA 1Q5NA 4V2RA 5EYTA 1TJUA 1TJWA 3E04A 3NO9A 3R6VA 2PTSA 1RE5A 2QGAB 1I0AA 1C3CA 1K7WA 1XWOA 1GKMA 1C3UA 2O7DA 1YISA 2O7EA 3R6QA 3GTDA 2PTQA 2PTRA 2VD6A 1FUPA 3KDZA 4C5UA 2J91A 4EEIA 3BHGA 5F91A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2X75 A;  2RJR A;  1HY1 A;  4MX2 A;  1T6J A;  2O7B A;  4FFX A;  1W27 A;  4C6G A;  4C5S A;  2RJS A;  3R6Y A;  1TJV A;  4ADL A;  2YII A;  2FUS A;  1J3U A;  1FUR A;  1GK2 A;  1FUO A;  4BAB A;  2HVG A;  1VDK A;  3GZH A;  4BAA A;  1AUW A;  1Y2M A;  1DOF A;  4C5R A;  1GK3 A;  3RRP A;  3CZO A;  1EB4 A;  1FUQ A;  1YFE A;  5EYV A;  3TV2 A;  5F92 A;  4APB A;  1YFM A;  4NLE A;  2PFM A;  4ADM A;  4EFC A;  1GKJ A;  5HW2 A;  1U16 A;  1HY0 A;  1K62 A;  2O78 A;  3NZ4 A;  4FLC A;  4V2Q A;  1U15 A;  2OHY A;  4HGV A;  1TJ7 A;  1T6P A;  5D6B A;  1JSW A;  1KQ7 A;  2E9F A;  3OCF A;  3QBP A;  2NYF A;  2O6Y A;  3OCE A;  2NYN A;  3RD8 A;  1B8F A;  4NSL A;  3UNV A;  2O7F A;  3KDY A;  4CQ5 A;  1DCN A;  3C8T A;  4APA A;  2QVE A;  1Q5N A;  4V2R A;  5EYT A;  1TJU A;  1TJW A;  3E04 A;  3NO9 A;  3R6V A;  2PTS A;  1RE5 A;  2QGA B;  1I0A A;  1C3C A;  1K7W A;  1XWO A;  1GKM A;  1C3U A;  2O7D A;  1YIS A;  2O7E A;  3R6Q A;  3GTD A;  2PTQ A;  2PTR A;  2VD6 A;  1FUP A;  3KDZ A;  4C5U A;  2J91 A;  4EEI A;  3BHG A;  5F91 A; 
#chains in the Genus database with same CATH topology
 2X75 A;  2RJR A;  2A69 D;  1HY1 A;  1WCM A;  4MX2 A;  2JA7 A;  1T6J A;  2O7B A;  4FFX A;  2FEL A;  1W27 A;  1R9T A;  2B63 A;  4C6G A;  4C5S A;  2RJS A;  3R6Y A;  1TJV A;  3FKI A;  2E2I A;  4ADL A;  2YII A;  2FUS A;  3CRW 1;  2EZA A;  4A15 A;  3LRD A;  4FBS A;  1I6V D;  1J3U A;  1XL8 A;  3EZB A;  1I3Q A;  2VK9 A;  3GTL A;  2LTH A;  1TWF A;  1FUR A;  3EZA A;  1I50 A;  1GK2 A;  2N3E A;  2LPJ A;  1FUO A;  2NVY A;  2MP0 A;  2JA5 A;  4BAB A;  1HQM D;  1XLY A;  2HVG A;  1VDK A;  3GZH A;  4BAA A;  3GTJ A;  1AUW A;  4WNL A;  1Y2M A;  1DOF A;  4C5R A;  1GK3 A;  3RRP A;  3CZO A;  1EB4 A;  1EZA A;  1FUQ A;  2X0P A;  1YFE A;  5EYV A;  3TV2 A;  4APB A;  5F92 A;  2HWG A;  1YFM A;  2PFM A;  4NLE A;  4ADM A;  4EFC A;  2VUM A;  1TWH A;  1GKJ A;  3GTQ A;  3GTG A;  2JA6 A;  1XMD A;  5HW2 A;  2AQL A;  1U16 A;  2A6E D;  3GTK A;  1HY0 A;  1K62 A;  5H8W A;  2N1D B;  2X0O A;  3NZ4 A;  2O78 A;  2FEN A;  4FLC A;  2A68 D;  2K3O A;  4V2Q A;  1K83 A;  1U15 A;  2OHY A;  4HGV A;  3EZE A;  1IW7 D;  2K3N A;  1T6P A;  2E2H A;  1TJ7 A;  3BHG A;  3U44 A;  1SFO A;  1JSW A;  2FIP A;  2R7Z A;  1XL7 A;  1KQ7 A;  5D6B A;  2E9F A;  2LPI A;  3GTP A;  3OCF A;  3QBP A;  2NYF A;  5M0I A;  1SMY D;  2O6Y A;  5M0J A;  3OCE A;  4C2M A;  2FIO A;  2YU9 A;  2NYN A;  3RD8 A;  4CEJ A;  1B8F A;  4NSL A;  3UNV A;  1TWA A;  2LYI A;  2O7F A;  1Y1W A;  3KDY A;  4CQ5 A;  1DCN A;  5IZ2 A;  3C8T A;  2LKM B;  2A6H D;  2QVE A;  2VSF A;  1YNJ D;  4APA A;  1TWC A;  1Q5N A;  4V2R A;  4CEI A;  5EYT A;  3GTO A;  1EZB A;  2R93 A;  3LR6 A;  1TJU A;  1TJW A;  3E04 A;  3NO9 A;  4QIW A;  3R6V A;  2EZB A;  2PTS A;  1RE5 A;  2QGA B;  2NVX A;  2CW0 D;  1ZYR D;  2BE5 D;  2O5J D;  1I0A A;  2F5J A;  1C3C A;  2VL7 A;  1K7W A;  1XWO A;  3CRV A;  1GKM A;  1C3U A;  2K3Q A;  1TWG A;  3LR2 A;  2R92 A;  2MX8 A;  1YIS A;  2MQA A;  2O7D A;  1ZYM A;  2O7E A;  3R6Q A;  2MX9 A;  3GTD A;  2EZC A;  2PTQ A;  2PTR A;  2HRO A;  2VD6 A;  1FUP A;  3KDZ A;  1XMC A;  2X0Q A;  2Y0N A;  1Y1V A;  4CEH A;  4C5U A;  3CQZ A;  2J91 A;  4EEI A;  3GTM A;  3U4Q A;  1YNN D;  3H0G A;  5F91 A;  3LR8 A; 
#chains in the Genus database with same CATH homology
 2X75 A;  2RJR A;  1HY1 A;  4MX2 A;  1T6J A;  2O7B A;  4FFX A;  1W27 A;  4C6G A;  4C5S A;  2RJS A;  3R6Y A;  1TJV A;  4ADL A;  2YII A;  2FUS A;  1J3U A;  1FUR A;  1GK2 A;  1FUO A;  4BAB A;  2HVG A;  1VDK A;  3GZH A;  4BAA A;  1AUW A;  1Y2M A;  1DOF A;  4C5R A;  1GK3 A;  3RRP A;  3CZO A;  1EB4 A;  1FUQ A;  1YFE A;  5EYV A;  3TV2 A;  5F92 A;  4APB A;  1YFM A;  4NLE A;  2PFM A;  4ADM A;  4EFC A;  1GKJ A;  5HW2 A;  1U16 A;  1HY0 A;  1K62 A;  2O78 A;  3NZ4 A;  4FLC A;  4V2Q A;  1U15 A;  2OHY A;  4HGV A;  1TJ7 A;  1T6P A;  5D6B A;  1JSW A;  1KQ7 A;  2E9F A;  3OCF A;  3QBP A;  2NYF A;  2O6Y A;  3OCE A;  2NYN A;  3RD8 A;  1B8F A;  4NSL A;  3UNV A;  2O7F A;  3KDY A;  4CQ5 A;  1DCN A;  3C8T A;  4APA A;  2QVE A;  1Q5N A;  4V2R A;  5EYT A;  1TJU A;  1TJW A;  3E04 A;  3NO9 A;  3R6V A;  2PTS A;  1RE5 A;  2QGA B;  1I0A A;  1C3C A;  1K7W A;  1XWO A;  1GKM A;  1C3U A;  2O7D A;  1YIS A;  2O7E A;  3R6Q A;  3GTD A;  2PTQ A;  2PTR A;  2VD6 A;  1FUP A;  3KDZ A;  4C5U A;  2J91 A;  4EEI A;  3BHG A;  5F91 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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