1Y2MA

Crystal structure of phenylalanine ammonia-lyase from yeast rhododporidium toruloides
Total Genus 244
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
244
sequence length
690
structure length
665
Chain Sequence
b'ASTNLAVAGSHLPTTQVTQVDIVEKMLAAPTDSTLELDGYSLNLGDVVSAARKGRPVRVKDSDEIRSKIDKSVEFLRTEDAISLQKALLEHQLCGVLPSSFDSFRLGRGLENSLPLEVVRGAMTIRVNSLTRGHSAVRLVVLEALTNFLNHGITPIVPLRGTISASGDLSPLSYIAAAISGHPDSKVHVVHEGKEKILYAREAMALFNLEPVVLGPKEGLGLVNGTAVSASMATLALHDAHMLSLLSQSLTAMTVEAMVGHAGSFHPFLHDVTRPHPTQIEVAGNIRKLLEGSRFAVHHEEEVDEGILRQDRYPLRTSPQWLGPLVSDLIHAHAVLTIEAGQSTTDNPLIDVENKTSHHGGNFQAAAVANTMEKTRLGLAQIGKLNFTQLTEMLNAGMNRGLPSCLAAEDPSLSYHCKGLDIAAAAYTSELGHLANPVTTHVQPAEMANQAVNSLALISARRTTESNDVLSLLLATHLYCVLQAIDLRAIEFEFKKQFGPAIVSLIDQHFGSAMTGSNLRDELVEKVNKTLAKRLEQTNSYDLVPRWHDAFSFAAGTVVEVLSSTSLSLAAVNAWKVAAAESAISLTRQVRETFWSAASTSSPALSYLSPRTQILYAFVREELGVKARRGDVFLGKQEVTIGSNVSKIYEAIKSGRINNVLLKML'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Phenylalanine ammonia-lyase
molecule tags Lyase
source organism Rhodosporidium toruloides
publication title Structure-based chemical modification strategy for enzyme replacement treatment of phenylketonuria.
pubmed doi rcsb
total genus 244
structure length 665
sequence length 690
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.25: Phenylalanine/tyrosine ammonia-lyase.
pdb deposition date 2004-11-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 1y2mA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1y2mA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1y2mA02
4C6GA 1I0AA 3OCFA 2O7BA 4C5UA 3QBPA 1K7WA 1TJUA 4BABA 4NSLA 2O7EA 1RE5A 4C5SA 4CQ5A 4FLCA 3KDYA 1TJVA 2E9FA 1DCNA 4MX2A 2QVEA 4APAA 1Y2MA 3BHGA 4ADMA 4V2RA 1C3UA 4C5RA 2PTRA 1FUPA 1YFMA 1YFEA 3KDZA 2HVGA 3OCEA 1HY0A 1JSWA 3UNVA 1KQ7A 1FUQA 5F91A 2J91A 4HGVA 1U16A 2O78A 3R6YA 2O6YA 3R6VA 4BAAA 1AUWA 3CZOA 5EYVA 3R6QA 3GZHA 2RJSA 3RD8A 1GK3A 3TV2A 3C8TA 2PTSA 1B8FA 2NYNA 1C3CA 2RJRA 3NZ4A 3NO9A 5EYTA 1T6JA 2VD6A 1GKMA 2NYFA 1Q5NA 1T6PA 4V2QA 4FFXA 1EB4A 1GKJA 1U15A 2OHYA 3E04A 4EEIA 1GK2A 5D6BA 2PTQA 2X75A 4ADLA 1TJWA 2O7FA 2O7DA 1TJ7A 4APBA 5HW2A 1FURA 1K62A 1XWOA 2YIIA 1J3UA 1YISA 4NLEA 1DOFA 2QGAB 3GTDA 2PFMA 1FUOA 1HY1A 1W27A 1VDKA 4EFCA 5F92A 3RRPA 2FUSA
chains in the Genus database with same CATH superfamily
4C6GA 1I0AA 3OCFA 2N1DB 2JA7A 2O7BA 2BE5D 4C5UA 2MP0A 2YU9A 1K7WA 3GTKA 1TJUA 3QBPA 4BABA 4NSLA 2O7EA 3LR2A 1HQMD 2R7ZA 1RE5A 4C5SA 2A6HD 1EZAA 2LPIA 4CQ5A 4FLCA 3KDYA 2A69D 2EZAA 1TJVA 2E9FA 1I3QA 2Y0NA 3GTGA 1DCNA 4MX2A 2LKMB 2QVEA 4APAA 1Y2MA 3BHGA 4ADMA 4V2RA 1WCMA 4C5RA 3GTOA 1C3UA 2PTRA 4A15A 2F5JA 4CEJA 3CQZA 1TWFA 1YNJD 2VSFA 1FUPA 2MQAA 3GTQA 2FENA 1YFMA 2MX9A 1TWCA 1YFEA 3KDZA 2HVGA 2A68D 3OCEA 1HY0A 1JSWA 3UNVA 2X0QA 1KQ7A 1FUQA 2A6ED 5F91A 3FKIA 2VL7A 2CW0D 2LPJA 1XLYA 2EZCA 3EZEA 2AQLA 2LTHA 3U4QA 2J91A 1K83A 3GTJA 2N3EA 4HGVA 1U16A 2O78A 2E2HA 3R6YA 3EZBA 2O6YA 1TWGA 2NVXA 3R6VA 4BAAA 2K3NA 1AUWA 2VK9A 3CZOA 2NVYA 5EYVA 3R6QA 1YNND 3GZHA 3GTMA 2RJSA 3RD8A 1GK3A 4C2MA 3TV2A 1XMCA 3C8TA 1SMYD 4FBSA 2PTSA 1B8FA 2LYIA 2NYNA 1C3CA 2RJRA 3EZAA 1TWHA 3NZ4A 3NO9A 2K3QA 5EYTA 1I50A 3GTPA 3H0GA 1T6JA 2VD6A 1GKMA 2NYFA 1EZBA 1Y1VA 4WNLA 1ZYMA 1Q5NA 2FELA 1T6PA 4V2QA 4FFXA 1EB4A 1GKJA 1I6VD 1U15A 2OHYA 3E04A 4EEIA 1GK2A 5D6BA 2PTQA 2X75A 4ADLA 2VUMA 1XL7A 5M0IA 1XMDA 1TJWA 3GTLA 2O7FA 3LR8A 2O7DA 4CEIA 1TJ7A 4APBA 5HW2A 1IW7D 1SFOA 1ZYRD 2B63A 2MX8A 3U44A 3LRDA 1FURA 1K62A 1XWOA 1R9TA 2R93A 2YIIA 1J3UA 2JA6A 1YISA 3CRVA 1DOFA 4NLEA 3LR6A 3CRW1 2E2IA 2QGAB 3GTDA 4QIWA 1Y1WA 2PFMA 1XL8A 2R92A 2HROA 1FUOA 2FIPA 2K3OA 1HY1A 5M0JA 2JA5A 2HWGA 1W27A 4CEHA 5IZ2A 2FIOA 1TWAA 2X0OA 1VDKA 4EFCA 5F92A 2EZBA 2X0PA 3RRPA 2FUSA 2O5JD 5H8WA
chains in the Genus database with same CATH topology
4C6GA 1I0AA 3OCFA 2O7BA 4C5UA 3QBPA 1K7WA 1TJUA 4BABA 4NSLA 2O7EA 1RE5A 4C5SA 4CQ5A 4FLCA 3KDYA 1TJVA 2E9FA 1DCNA 4MX2A 2QVEA 4APAA 1Y2MA 3BHGA 4ADMA 4V2RA 1C3UA 4C5RA 2PTRA 1FUPA 1YFMA 1YFEA 3KDZA 2HVGA 3OCEA 1HY0A 1JSWA 3UNVA 1KQ7A 1FUQA 5F91A 2J91A 4HGVA 1U16A 2O78A 3R6YA 2O6YA 3R6VA 4BAAA 1AUWA 3CZOA 5EYVA 3R6QA 3GZHA 2RJSA 3RD8A 1GK3A 3TV2A 3C8TA 2PTSA 1B8FA 2NYNA 1C3CA 2RJRA 3NZ4A 3NO9A 5EYTA 1T6JA 2VD6A 1GKMA 2NYFA 1Q5NA 1T6PA 4V2QA 4FFXA 1EB4A 1GKJA 1U15A 2OHYA 3E04A 4EEIA 1GK2A 5D6BA 2PTQA 2X75A 4ADLA 1TJWA 2O7FA 2O7DA 1TJ7A 4APBA 5HW2A 1FURA 1K62A 1XWOA 2YIIA 1J3UA 1YISA 4NLEA 1DOFA 2QGAB 3GTDA 2PFMA 1FUOA 1HY1A 1W27A 1VDKA 4EFCA 5F92A 3RRPA 2FUSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4C6G A;  1I0A A;  3OCF A;  2O7B A;  4C5U A;  3QBP A;  1K7W A;  1TJU A;  4BAB A;  4NSL A;  2O7E A;  1RE5 A;  4C5S A;  4CQ5 A;  4FLC A;  3KDY A;  1TJV A;  2E9F A;  1DCN A;  4MX2 A;  2QVE A;  4APA A;  1Y2M A;  3BHG A;  4ADM A;  4V2R A;  1C3U A;  4C5R A;  2PTR A;  1FUP A;  1YFM A;  1YFE A;  3KDZ A;  2HVG A;  3OCE A;  1HY0 A;  1JSW A;  3UNV A;  1KQ7 A;  1FUQ A;  5F91 A;  2J91 A;  4HGV A;  1U16 A;  2O78 A;  3R6Y A;  2O6Y A;  3R6V A;  4BAA A;  1AUW A;  3CZO A;  5EYV A;  3R6Q A;  3GZH A;  2RJS A;  3RD8 A;  1GK3 A;  3TV2 A;  3C8T A;  2PTS A;  1B8F A;  2NYN A;  1C3C A;  2RJR A;  3NZ4 A;  3NO9 A;  5EYT A;  1T6J A;  2VD6 A;  1GKM A;  2NYF A;  1Q5N A;  1T6P A;  4V2Q A;  4FFX A;  1EB4 A;  1GKJ A;  1U15 A;  2OHY A;  3E04 A;  4EEI A;  1GK2 A;  5D6B A;  2PTQ A;  2X75 A;  4ADL A;  1TJW A;  2O7F A;  2O7D A;  1TJ7 A;  4APB A;  5HW2 A;  1FUR A;  1K62 A;  1XWO A;  2YII A;  1J3U A;  1YIS A;  4NLE A;  1DOF A;  2QGA B;  3GTD A;  2PFM A;  1FUO A;  1HY1 A;  1W27 A;  1VDK A;  4EFC A;  5F92 A;  3RRP A;  2FUS A; 
#chains in the Genus database with same CATH topology
 4C6G A;  1I0A A;  3OCF A;  2N1D B;  2JA7 A;  2O7B A;  2BE5 D;  4C5U A;  2MP0 A;  2YU9 A;  1K7W A;  3GTK A;  1TJU A;  3QBP A;  4BAB A;  4NSL A;  2O7E A;  3LR2 A;  1HQM D;  2R7Z A;  1RE5 A;  4C5S A;  2A6H D;  1EZA A;  2LPI A;  4CQ5 A;  4FLC A;  3KDY A;  2A69 D;  2EZA A;  1TJV A;  2E9F A;  1I3Q A;  2Y0N A;  3GTG A;  1DCN A;  4MX2 A;  2LKM B;  2QVE A;  4APA A;  1Y2M A;  3BHG A;  4ADM A;  4V2R A;  1WCM A;  4C5R A;  3GTO A;  1C3U A;  2PTR A;  4A15 A;  2F5J A;  4CEJ A;  3CQZ A;  1TWF A;  1YNJ D;  2VSF A;  1FUP A;  2MQA A;  3GTQ A;  2FEN A;  1YFM A;  2MX9 A;  1TWC A;  1YFE A;  3KDZ A;  2HVG A;  2A68 D;  3OCE A;  1HY0 A;  1JSW A;  3UNV A;  2X0Q A;  1KQ7 A;  1FUQ A;  2A6E D;  5F91 A;  3FKI A;  2VL7 A;  2CW0 D;  2LPJ A;  1XLY A;  2EZC A;  3EZE A;  2AQL A;  2LTH A;  3U4Q A;  2J91 A;  1K83 A;  3GTJ A;  2N3E A;  4HGV A;  1U16 A;  2O78 A;  2E2H A;  3R6Y A;  3EZB A;  2O6Y A;  1TWG A;  2NVX A;  3R6V A;  4BAA A;  2K3N A;  1AUW A;  2VK9 A;  3CZO A;  2NVY A;  5EYV A;  3R6Q A;  1YNN D;  3GZH A;  3GTM A;  2RJS A;  3RD8 A;  1GK3 A;  4C2M A;  3TV2 A;  1XMC A;  3C8T A;  1SMY D;  4FBS A;  2PTS A;  1B8F A;  2LYI A;  2NYN A;  1C3C A;  2RJR A;  3EZA A;  1TWH A;  3NZ4 A;  3NO9 A;  2K3Q A;  5EYT A;  1I50 A;  3GTP A;  3H0G A;  1T6J A;  2VD6 A;  1GKM A;  2NYF A;  1EZB A;  1Y1V A;  4WNL A;  1ZYM A;  1Q5N A;  2FEL A;  1T6P A;  4V2Q A;  4FFX A;  1EB4 A;  1GKJ A;  1I6V D;  1U15 A;  2OHY A;  3E04 A;  4EEI A;  1GK2 A;  5D6B A;  2PTQ A;  2X75 A;  4ADL A;  2VUM A;  1XL7 A;  5M0I A;  1XMD A;  1TJW A;  3GTL A;  2O7F A;  3LR8 A;  2O7D A;  4CEI A;  1TJ7 A;  4APB A;  5HW2 A;  1IW7 D;  1SFO A;  1ZYR D;  2B63 A;  2MX8 A;  3U44 A;  3LRD A;  1FUR A;  1K62 A;  1XWO A;  1R9T A;  2R93 A;  2YII A;  1J3U A;  2JA6 A;  1YIS A;  3CRV A;  1DOF A;  4NLE A;  3LR6 A;  3CRW 1;  2E2I A;  2QGA B;  3GTD A;  4QIW A;  1Y1W A;  2PFM A;  1XL8 A;  2R92 A;  2HRO A;  1FUO A;  2FIP A;  2K3O A;  1HY1 A;  5M0J A;  2JA5 A;  2HWG A;  1W27 A;  4CEH A;  5IZ2 A;  2FIO A;  1TWA A;  2X0O A;  1VDK A;  4EFC A;  5F92 A;  2EZB A;  2X0P A;  3RRP A;  2FUS A;  2O5J D;  5H8W A; 
#chains in the Genus database with same CATH homology
 4C6G A;  1I0A A;  3OCF A;  2O7B A;  4C5U A;  3QBP A;  1K7W A;  1TJU A;  4BAB A;  4NSL A;  2O7E A;  1RE5 A;  4C5S A;  4CQ5 A;  4FLC A;  3KDY A;  1TJV A;  2E9F A;  1DCN A;  4MX2 A;  2QVE A;  4APA A;  1Y2M A;  3BHG A;  4ADM A;  4V2R A;  1C3U A;  4C5R A;  2PTR A;  1FUP A;  1YFM A;  1YFE A;  3KDZ A;  2HVG A;  3OCE A;  1HY0 A;  1JSW A;  3UNV A;  1KQ7 A;  1FUQ A;  5F91 A;  2J91 A;  4HGV A;  1U16 A;  2O78 A;  3R6Y A;  2O6Y A;  3R6V A;  4BAA A;  1AUW A;  3CZO A;  5EYV A;  3R6Q A;  3GZH A;  2RJS A;  3RD8 A;  1GK3 A;  3TV2 A;  3C8T A;  2PTS A;  1B8F A;  2NYN A;  1C3C A;  2RJR A;  3NZ4 A;  3NO9 A;  5EYT A;  1T6J A;  2VD6 A;  1GKM A;  2NYF A;  1Q5N A;  1T6P A;  4V2Q A;  4FFX A;  1EB4 A;  1GKJ A;  1U15 A;  2OHY A;  3E04 A;  4EEI A;  1GK2 A;  5D6B A;  2PTQ A;  2X75 A;  4ADL A;  1TJW A;  2O7F A;  2O7D A;  1TJ7 A;  4APB A;  5HW2 A;  1FUR A;  1K62 A;  1XWO A;  2YII A;  1J3U A;  1YIS A;  4NLE A;  1DOF A;  2QGA B;  3GTD A;  2PFM A;  1FUO A;  1HY1 A;  1W27 A;  1VDK A;  4EFC A;  5F92 A;  3RRP A;  2FUS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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