1Y2MA

Crystal structure of phenylalanine ammonia-lyase from yeast rhododporidium toruloides
Total Genus 244
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
244
sequence length
690
structure length
665
Chain Sequence
ASTNLAVAGSHLPTTQVTQVDIVEKMLAAPTDSTLELDGYSLNLGDVVSAARKGRPVRVKDSDEIRSKIDKSVEFLRTEDAISLQKALLEHQLCGVLPSSFDSFRLGRGLENSLPLEVVRGAMTIRVNSLTRGHSAVRLVVLEALTNFLNHGITPIVPLRGTISASGDLSPLSYIAAAISGHPDSKVHVVHEGKEKILYAREAMALFNLEPVVLGPKEGLGLVNGTAVSASMATLALHDAHMLSLLSQSLTAMTVEAMVGHAGSFHPFLHDVTRPHPTQIEVAGNIRKLLEGSRFAVHHEEEVDEGILRQDRYPLRTSPQWLGPLVSDLIHAHAVLTIEAGQSTTDNPLIDVENKTSHHGGNFQAAAVANTMEKTRLGLAQIGKLNFTQLTEMLNAGMNRGLPSCLAAEDPSLSYHCKGLDIAAAAYTSELGHLANPVTTHVQPAEMANQAVNSLALISARRTTESNDVLSLLLATHLYCVLQAIDLRAIEFEFKKQFGPAIVSLIDQHFGSAMTGSNLRDELVEKVNKTLAKRLEQTNSYDLVPRWHDAFSFAAGTVVEVLSSTSLSLAAVNAWKVAAAESAISLTRQVRETFWSAASTSSPALSYLSPRTQILYAFVREELGVKARRGDVFLGKQEVTIGSNVSKIYEAIKSGRINNVLLKML
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Lyase
molecule keywords Phenylalanine ammonia-lyase
publication title Structure-based chemical modification strategy for enzyme replacement treatment of phenylketonuria.
pubmed doi rcsb
source organism Rhodosporidium toruloides
total genus 244
structure length 665
sequence length 690
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.25: Phenylalanine/tyrosine ammonia-lyase.
pdb deposition date 2004-11-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 1y2mA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1y2mA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1y2mA02
4MX2A 4BABA 3R6VA 4EFCA 1GK3A 1TJVA 1EB4A 2QGAB 1HY0A 4NSLA 1TJUA 1RE5A 4APAA 4NLEA 1KQ7A 1U16A 5D6BA 4CQ5A 2PTSA 2NYFA 2O7EA 3TV2A 4V2QA 3RRPA 3KDZA 2PFMA 2RJSA 2O7BA 4APBA 1B8FA 1FUPA 1GK2A 1FUQA 1HY1A 1U15A 2O6YA 3OCEA 1FURA 1YFMA 3BHGA 1FUOA 4ADLA 4EEIA 2O7FA 4BAAA 3RD8A 2J91A 3NZ4A 1Q5NA 5F91A 3QBPA 2VD6A 2QVEA 1K62A 1J3UA 1YISA 3OCFA 2HVGA 2PTQA 3R6YA 4ADMA 1I0AA 1DCNA 1VDKA 1YFEA 1GKMA 4C5UA 3UNVA 1K7WA 2E9FA 1C3UA 1AUWA 3NO9A 5F92A 2X75A 2O78A 2O7DA 5EYTA 1T6PA 1TJWA 3GZHA 1Y2MA 4V2RA 4C5RA 1TJ7A 3CZOA 2RJRA 3C8TA 3GTDA 3R6QA 2YIIA 2NYNA 1C3CA 4FFXA 1XWOA 2OHYA 1GKJA 4C6GA 3E04A 5EYVA 1W27A 1T6JA 2FUSA 4HGVA 3KDYA 4FLCA 4C5SA 2PTRA 5HW2A 1DOFA 1JSWA
chains in the Genus database with same CATH superfamily
2AQLA 3EZEA 2E2IA 2LKMB 1I50A 3EZBA 4MX2A 4C2MA 2LPIA 4BABA 2EZAA 3R6VA 4EFCA 1GK3A 2X0OA 2MX8A 1TJVA 1TWAA 1EB4A 1HY0A 2QGAB 4NSLA 5H8WA 2FIPA 2FELA 1TJUA 1EZAA 3LR6A 1RE5A 4NLEA 4APAA 1KQ7A 2JA6A 2MQAA 1U16A 1ZYMA 3GTGA 3LR2A 5D6BA 4CQ5A 2PTSA 2NYFA 2O7EA 3TV2A 2X0QA 1HQMD 2VK9A 2N3EA 4V2QA 3RRPA 3KDZA 2PFMA 1K83A 2RJSA 3CRW1 3LRDA 1XL8A 3U44A 1R9TA 1I3QA 4CEHA 2O7BA 2VSFA 4APBA 1B8FA 1FUPA 1GK2A 1Y1VA 1FUQA 2VL7A 1HY1A 1TWCA 1U15A 2MX9A 2O6YA 2N1DB 2A6HD 1FURA 3OCEA 1YFMA 3BHGA 2LPJA 2CW0D 3CQZA 1XLYA 2FIOA 3CRVA 2F5JA 1FUOA 4ADLA 4EEIA 2O7FA 2LTHA 3EZAA 4BAAA 1TWFA 2B63A 1Y1WA 3RD8A 2J91A 3NZ4A 1Q5NA 4A15A 1SMYD 5F91A 3QBPA 2VD6A 2K3OA 2O5JD 2QVEA 4CEIA 2HROA 1K62A 2A69D 3LR8A 3U4QA 1J3UA 2Y0NA 1YISA 3OCFA 2EZCA 1XMDA 2K3QA 2HVGA 2NVYA 2PTQA 3R6YA 4ADMA 1I0AA 3FKIA 1DCNA 1VDKA 5M0IA 1YFEA 1GKMA 4C5UA 3UNVA 1K7WA 2E9FA 2E2HA 1XL7A 4WNLA 1C3UA 2HWGA 4CEJA 2YU9A 1TWGA 2R93A 1AUWA 3NO9A 5F92A 2X75A 2FENA 2X0PA 2A6ED 4FBSA 2A68D 2O78A 2O7DA 5EYTA 1T6PA 1WCMA 3GTPA 1TJWA 3GZHA 1Y2MA 1EZBA 4V2RA 4C5RA 1TJ7A 3CZOA 1TWHA 1ZYRD 2RJRA 1YNND 2K3NA 1YNJD 3C8TA 3GTDA 3R6QA 2EZBA 2YIIA 2R7ZA 1I6VD 1XMCA 2NYNA 2BE5D 2NVXA 2JA7A 3H0GA 3GTLA 1C3CA 4FFXA 1XWOA 2OHYA 1SFOA 1GKJA 4C6GA 2MP0A 3E04A 2LYIA 2R92A 3GTOA 4QIWA 2JA5A 5EYVA 1W27A 1T6JA 2FUSA 4HGVA 3KDYA 4FLCA 5IZ2A 4C5SA 3GTMA 2PTRA 3GTJA 3GTKA 3GTQA 5HW2A 1DOFA 1JSWA 2VUMA 5M0JA 1IW7D
chains in the Genus database with same CATH topology
4MX2A 4BABA 3R6VA 4EFCA 1GK3A 1TJVA 1EB4A 2QGAB 1HY0A 4NSLA 1TJUA 1RE5A 4APAA 4NLEA 1KQ7A 1U16A 5D6BA 4CQ5A 2PTSA 2NYFA 2O7EA 3TV2A 4V2QA 3RRPA 3KDZA 2PFMA 2RJSA 2O7BA 4APBA 1B8FA 1FUPA 1GK2A 1FUQA 1HY1A 1U15A 2O6YA 3OCEA 1FURA 1YFMA 3BHGA 1FUOA 4ADLA 4EEIA 2O7FA 4BAAA 3RD8A 2J91A 3NZ4A 1Q5NA 5F91A 3QBPA 2VD6A 2QVEA 1K62A 1J3UA 1YISA 3OCFA 2HVGA 2PTQA 3R6YA 4ADMA 1I0AA 1DCNA 1VDKA 1YFEA 1GKMA 4C5UA 3UNVA 1K7WA 2E9FA 1C3UA 1AUWA 3NO9A 5F92A 2X75A 2O78A 2O7DA 5EYTA 1T6PA 1TJWA 3GZHA 1Y2MA 4V2RA 4C5RA 1TJ7A 3CZOA 2RJRA 3C8TA 3GTDA 3R6QA 2YIIA 2NYNA 1C3CA 4FFXA 1XWOA 2OHYA 1GKJA 4C6GA 3E04A 5EYVA 1W27A 1T6JA 2FUSA 4HGVA 3KDYA 4FLCA 4C5SA 2PTRA 5HW2A 1DOFA 1JSWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MX2 A;  4BAB A;  3R6V A;  4EFC A;  1GK3 A;  1TJV A;  1EB4 A;  2QGA B;  1HY0 A;  4NSL A;  1TJU A;  1RE5 A;  4APA A;  4NLE A;  1KQ7 A;  1U16 A;  5D6B A;  4CQ5 A;  2PTS A;  2NYF A;  2O7E A;  3TV2 A;  4V2Q A;  3RRP A;  3KDZ A;  2PFM A;  2RJS A;  2O7B A;  4APB A;  1B8F A;  1FUP A;  1GK2 A;  1FUQ A;  1HY1 A;  1U15 A;  2O6Y A;  3OCE A;  1FUR A;  1YFM A;  3BHG A;  1FUO A;  4ADL A;  4EEI A;  2O7F A;  4BAA A;  3RD8 A;  2J91 A;  3NZ4 A;  1Q5N A;  5F91 A;  3QBP A;  2VD6 A;  2QVE A;  1K62 A;  1J3U A;  1YIS A;  3OCF A;  2HVG A;  2PTQ A;  3R6Y A;  4ADM A;  1I0A A;  1DCN A;  1VDK A;  1YFE A;  1GKM A;  4C5U A;  3UNV A;  1K7W A;  2E9F A;  1C3U A;  1AUW A;  3NO9 A;  5F92 A;  2X75 A;  2O78 A;  2O7D A;  5EYT A;  1T6P A;  1TJW A;  3GZH A;  1Y2M A;  4V2R A;  4C5R A;  1TJ7 A;  3CZO A;  2RJR A;  3C8T A;  3GTD A;  3R6Q A;  2YII A;  2NYN A;  1C3C A;  4FFX A;  1XWO A;  2OHY A;  1GKJ A;  4C6G A;  3E04 A;  5EYV A;  1W27 A;  1T6J A;  2FUS A;  4HGV A;  3KDY A;  4FLC A;  4C5S A;  2PTR A;  5HW2 A;  1DOF A;  1JSW A; 
#chains in the Genus database with same CATH topology
 2AQL A;  3EZE A;  2E2I A;  2LKM B;  1I50 A;  3EZB A;  4MX2 A;  4C2M A;  2LPI A;  4BAB A;  2EZA A;  3R6V A;  4EFC A;  1GK3 A;  2X0O A;  2MX8 A;  1TJV A;  1TWA A;  1EB4 A;  1HY0 A;  2QGA B;  4NSL A;  5H8W A;  2FIP A;  2FEL A;  1TJU A;  1EZA A;  3LR6 A;  1RE5 A;  4NLE A;  4APA A;  1KQ7 A;  2JA6 A;  2MQA A;  1U16 A;  1ZYM A;  3GTG A;  3LR2 A;  5D6B A;  4CQ5 A;  2PTS A;  2NYF A;  2O7E A;  3TV2 A;  2X0Q A;  1HQM D;  2VK9 A;  2N3E A;  4V2Q A;  3RRP A;  3KDZ A;  2PFM A;  1K83 A;  2RJS A;  3CRW 1;  3LRD A;  1XL8 A;  3U44 A;  1R9T A;  1I3Q A;  4CEH A;  2O7B A;  2VSF A;  4APB A;  1B8F A;  1FUP A;  1GK2 A;  1Y1V A;  1FUQ A;  2VL7 A;  1HY1 A;  1TWC A;  1U15 A;  2MX9 A;  2O6Y A;  2N1D B;  2A6H D;  1FUR A;  3OCE A;  1YFM A;  3BHG A;  2LPJ A;  2CW0 D;  3CQZ A;  1XLY A;  2FIO A;  3CRV A;  2F5J A;  1FUO A;  4ADL A;  4EEI A;  2O7F A;  2LTH A;  3EZA A;  4BAA A;  1TWF A;  2B63 A;  1Y1W A;  3RD8 A;  2J91 A;  3NZ4 A;  1Q5N A;  4A15 A;  1SMY D;  5F91 A;  3QBP A;  2VD6 A;  2K3O A;  2O5J D;  2QVE A;  4CEI A;  2HRO A;  1K62 A;  2A69 D;  3LR8 A;  3U4Q A;  1J3U A;  2Y0N A;  1YIS A;  3OCF A;  2EZC A;  1XMD A;  2K3Q A;  2HVG A;  2NVY A;  2PTQ A;  3R6Y A;  4ADM A;  1I0A A;  3FKI A;  1DCN A;  1VDK A;  5M0I A;  1YFE A;  1GKM A;  4C5U A;  3UNV A;  1K7W A;  2E9F A;  2E2H A;  1XL7 A;  4WNL A;  1C3U A;  2HWG A;  4CEJ A;  2YU9 A;  1TWG A;  2R93 A;  1AUW A;  3NO9 A;  5F92 A;  2X75 A;  2FEN A;  2X0P A;  2A6E D;  4FBS A;  2A68 D;  2O78 A;  2O7D A;  5EYT A;  1T6P A;  1WCM A;  3GTP A;  1TJW A;  3GZH A;  1Y2M A;  1EZB A;  4V2R A;  4C5R A;  1TJ7 A;  3CZO A;  1TWH A;  1ZYR D;  2RJR A;  1YNN D;  2K3N A;  1YNJ D;  3C8T A;  3GTD A;  3R6Q A;  2EZB A;  2YII A;  2R7Z A;  1I6V D;  1XMC A;  2NYN A;  2BE5 D;  2NVX A;  2JA7 A;  3H0G A;  3GTL A;  1C3C A;  4FFX A;  1XWO A;  2OHY A;  1SFO A;  1GKJ A;  4C6G A;  2MP0 A;  3E04 A;  2LYI A;  2R92 A;  3GTO A;  4QIW A;  2JA5 A;  5EYV A;  1W27 A;  1T6J A;  2FUS A;  4HGV A;  3KDY A;  4FLC A;  5IZ2 A;  4C5S A;  3GTM A;  2PTR A;  3GTJ A;  3GTK A;  3GTQ A;  5HW2 A;  1DOF A;  1JSW A;  2VUM A;  5M0J A;  1IW7 D; 
#chains in the Genus database with same CATH homology
 4MX2 A;  4BAB A;  3R6V A;  4EFC A;  1GK3 A;  1TJV A;  1EB4 A;  2QGA B;  1HY0 A;  4NSL A;  1TJU A;  1RE5 A;  4APA A;  4NLE A;  1KQ7 A;  1U16 A;  5D6B A;  4CQ5 A;  2PTS A;  2NYF A;  2O7E A;  3TV2 A;  4V2Q A;  3RRP A;  3KDZ A;  2PFM A;  2RJS A;  2O7B A;  4APB A;  1B8F A;  1FUP A;  1GK2 A;  1FUQ A;  1HY1 A;  1U15 A;  2O6Y A;  3OCE A;  1FUR A;  1YFM A;  3BHG A;  1FUO A;  4ADL A;  4EEI A;  2O7F A;  4BAA A;  3RD8 A;  2J91 A;  3NZ4 A;  1Q5N A;  5F91 A;  3QBP A;  2VD6 A;  2QVE A;  1K62 A;  1J3U A;  1YIS A;  3OCF A;  2HVG A;  2PTQ A;  3R6Y A;  4ADM A;  1I0A A;  1DCN A;  1VDK A;  1YFE A;  1GKM A;  4C5U A;  3UNV A;  1K7W A;  2E9F A;  1C3U A;  1AUW A;  3NO9 A;  5F92 A;  2X75 A;  2O78 A;  2O7D A;  5EYT A;  1T6P A;  1TJW A;  3GZH A;  1Y2M A;  4V2R A;  4C5R A;  1TJ7 A;  3CZO A;  2RJR A;  3C8T A;  3GTD A;  3R6Q A;  2YII A;  2NYN A;  1C3C A;  4FFX A;  1XWO A;  2OHY A;  1GKJ A;  4C6G A;  3E04 A;  5EYV A;  1W27 A;  1T6J A;  2FUS A;  4HGV A;  3KDY A;  4FLC A;  4C5S A;  2PTR A;  5HW2 A;  1DOF A;  1JSW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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