1YHQE

Crystal structure of azithromycin bound to the g2099a mutant 50s ribosomal subunit of haloarcula marismortui
Total Genus 37
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
37
sequence length
172
structure length
172
Chain Sequence
PRVELEIPEDVDAEQDHLDITVEGDNGSVTRRLWYPDIDVSVDGDTVVIESDEDNAKTMSTIGTFQSHIENMFHGVTEGWEYGMEVFYSHFPMQVNVEGDEVVIENFLGEKAPRRTTIHGDTDVEIDGEELTVSGPDIEAVGQTAADIEQLTRINDKDVRVFQDGVYITRKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance.
pubmed doi rcsb
molecule tags Ribosome
molecule keywords 23S Ribosomal RNA
total genus 37
structure length 172
sequence length 172
ec nomenclature
pdb deposition date 2005-01-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF00347 Ribosomal_L6 Ribosomal protein L6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.930.12 Alpha Beta Alpha-Beta Complex Outer Surface Protein A; domain 3 Ribosomal protein L6, alpha-beta domain 1yhqE02
3.90.930.12 Alpha Beta Alpha-Beta Complex Outer Surface Protein A; domain 3 Ribosomal protein L6, alpha-beta domain 1yhqE01
3I56E 1Q82G 5JVHE 1M1KG 5GAHG 1Q7YG 3CC4E 4IOAE 5GAGG 5GAEG 1KC8G 4WF9E 3CXCE 1K9MG 1QVFE 3G6EE 1S72E 1KQSE 1VQLE 3PIPE 1M90G 2QEXE 1YJNE 3CCRE 3CC7E 4IOCE 5DM7E 2ZJRE 4U67E 5AN9B 2OTLE 1YIJE 3CCEE 1VQ9E 3CCLE 1Q81G 4WCEE 2CQLA 3CC2E 4WFNE 1JJ2E 1YJWE 1QVGE 3DLLE 1YHQE 1YITE 1YI2E 5DM6E 4WFBE 3CCUE 3CD6E 3PIOE 1VQPE 1W2BE 5MLCH 3CCJE 3J7ZG 1VQ7E 4UY8G 1VQNE 3G71E 1VQ5E 3CF5E 1KD1G 2QA4E 1VQ8E 1Q86G 5HL7E 5H1SI 3CPWE 3CMAE 3CCSE 1VQKE 3I55E 5JVGE 4IO9E 2ZJPE 1RL6A 1YJ9E 1K73G 1NJIG 1VQ4E 1K8AG 3CMEE 1VQME 3CCVE 1VQOE 2OTJE 3CCQE 1VQ6E 2ZJQE 3G4SE 3OW2E 3CCME 5GADG 4WFAE 1N8RG
chains in the Genus database with same CATH superfamily
2OL8O 3I56E 2OYBO 1Q82G 5JVHE 5B11O 1M1KG 5GAHG 2OY1O 1Q7YG 2HKDA 3CC4E 4IOAE 5GAGG 2OL6O 5GAEG 3AUMO 2PI3O 3IGEA 1KC8G 4WF9E 3CXCE 1K9MG 1QVFE 3G6EE 5B10O 1S72E 1KQSE 1VQLE 3PIPE 1M90G 2QEXE 1YJNE 2OY8A 3CCRE 3CC7E 4IOCE 5DM7E 5B2AO 2ZJRE 2OL7A 4U67E 5AN9B 1N8RG 2OTLE 1YIJE 2OY5O 3CCEE 1VQ9E 3CCLE 1Q81G 1P4PA 1FJ1E 4WCEE 2CQLA 3CC2E 4WFNE 1JJ2E 1YJWE 1QVGE 3DLLE 2I5VO 1YHQE 1YITE 1YI2E 5DM6E 4WFBE 3CCUE 1RJLC 2FKJA 3CD6E 3PIOE 1VQPE 1W2BE 1OSPO 3CCJE 3J7ZG 1VQ7E 2I5ZO 4UY8G 1VQNE 3G71E 2FKGA 2AF5A 1VQ5E 3CF5E 1KD1G 2QA4E 1VQ8E 1Q86G 5HL7E 5H1SI 3CPWE 5B3MO 2G8CO 3CMAE 3CCSE 1VQKE 3I55E 5JVGE 4IO9E 3EC5A 2ZJPE 2OY7A 1RL6A 1YJ9E 1K73G 1NJIG 1VQ4E 1K8AG 3CMEE 1VQME 3CCVE 1VQOE 2OTJE 3CCQE 3IG9A 1VQ6E 2ZJQE 3CKFA 3G4SE 3OW2E 3CCME 5GADG 3CKGA 4WFAE 5MLCH
chains in the Genus database with same CATH topology
3I56E 1Q82G 5JVHE 1M1KG 5GAHG 1Q7YG 3CC4E 4IOAE 5GAGG 5GAEG 1KC8G 4WF9E 3CXCE 1K9MG 1QVFE 3G6EE 1S72E 1KQSE 1VQLE 3PIPE 1M90G 2QEXE 1YJNE 3CCRE 3CC7E 4IOCE 5DM7E 2ZJRE 4U67E 5AN9B 2OTLE 1YIJE 3CCEE 1VQ9E 3CCLE 1Q81G 4WCEE 2CQLA 3CC2E 4WFNE 1JJ2E 1YJWE 1QVGE 3DLLE 1YHQE 1YITE 1YI2E 5DM6E 4WFBE 3CCUE 3CD6E 3PIOE 1VQPE 1W2BE 5MLCH 3CCJE 3J7ZG 1VQ7E 4UY8G 1VQNE 3G71E 1VQ5E 3CF5E 1KD1G 2QA4E 1VQ8E 1Q86G 5HL7E 5H1SI 3CPWE 3CMAE 3CCSE 1VQKE 3I55E 5JVGE 4IO9E 2ZJPE 1RL6A 1YJ9E 1K73G 1NJIG 1VQ4E 1K8AG 3CMEE 1VQME 3CCVE 1VQOE 2OTJE 3CCQE 1VQ6E 2ZJQE 3G4SE 3OW2E 3CCME 5GADG 4WFAE 1N8RG
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3I56 E;  1Q82 G;  5JVH E;  1M1K G;  5GAH G;  1Q7Y G;  3CC4 E;  4IOA E;  5GAG G;  5GAE G;  1KC8 G;  4WF9 E;  3CXC E;  1K9M G;  1QVF E;  3G6E E;  1S72 E;  1KQS E;  1VQL E;  3PIP E;  1M90 G;  2QEX E;  1YJN E;  3CCR E;  3CC7 E;  4IOC E;  5DM7 E;  2ZJR E;  4U67 E;  5AN9 B;  2OTL E;  1YIJ E;  3CCE E;  1VQ9 E;  3CCL E;  1Q81 G;  4WCE E;  2CQL A;  3CC2 E;  4WFN E;  1JJ2 E;  1YJW E;  1QVG E;  3DLL E;  1YHQ E;  1YIT E;  1YI2 E;  5DM6 E;  4WFB E;  3CCU E;  3CD6 E;  3PIO E;  1VQP E;  1W2B E;  5MLC H;  3CCJ E;  3J7Z G;  1VQ7 E;  4UY8 G;  1VQN E;  3G71 E;  1VQ5 E;  3CF5 E;  1KD1 G;  2QA4 E;  1VQ8 E;  1Q86 G;  5HL7 E;  5H1S I;  3CPW E;  3CMA E;  3CCS E;  1VQK E;  3I55 E;  5JVG E;  4IO9 E;  2ZJP E;  1RL6 A;  1YJ9 E;  1K73 G;  1NJI G;  1VQ4 E;  1K8A G;  3CME E;  1VQM E;  3CCV E;  1VQO E;  2OTJ E;  3CCQ E;  1VQ6 E;  2ZJQ E;  3G4S E;  3OW2 E;  3CCM E;  5GAD G;  4WFA E;  1N8R G; 
#chains in the Genus database with same CATH topology
 2OL8 O;  3I56 E;  2OYB O;  1Q82 G;  5JVH E;  5B11 O;  1M1K G;  5GAH G;  2OY1 O;  1Q7Y G;  2HKD A;  3CC4 E;  4IOA E;  5GAG G;  2OL6 O;  5GAE G;  3AUM O;  2PI3 O;  3IGE A;  1KC8 G;  4WF9 E;  3CXC E;  1K9M G;  1QVF E;  3G6E E;  5B10 O;  1S72 E;  1KQS E;  1VQL E;  3PIP E;  1M90 G;  2QEX E;  1YJN E;  2OY8 A;  3CCR E;  3CC7 E;  4IOC E;  5DM7 E;  5B2A O;  2ZJR E;  2OL7 A;  4U67 E;  5AN9 B;  1N8R G;  2OTL E;  1YIJ E;  2OY5 O;  3CCE E;  1VQ9 E;  3CCL E;  1Q81 G;  1P4P A;  1FJ1 E;  4WCE E;  2CQL A;  3CC2 E;  4WFN E;  1JJ2 E;  1YJW E;  1QVG E;  3DLL E;  2I5V O;  1YHQ E;  1YIT E;  1YI2 E;  5DM6 E;  4WFB E;  3CCU E;  1RJL C;  2FKJ A;  3CD6 E;  3PIO E;  1VQP E;  1W2B E;  1OSP O;  3CCJ E;  3J7Z G;  1VQ7 E;  2I5Z O;  4UY8 G;  1VQN E;  3G71 E;  2FKG A;  2AF5 A;  1VQ5 E;  3CF5 E;  1KD1 G;  2QA4 E;  1VQ8 E;  1Q86 G;  5HL7 E;  5H1S I;  3CPW E;  5B3M O;  2G8C O;  3CMA E;  3CCS E;  1VQK E;  3I55 E;  5JVG E;  4IO9 E;  3EC5 A;  2ZJP E;  2OY7 A;  1RL6 A;  1YJ9 E;  1K73 G;  1NJI G;  1VQ4 E;  1K8A G;  3CME E;  1VQM E;  3CCV E;  1VQO E;  2OTJ E;  3CCQ E;  3IG9 A;  1VQ6 E;  2ZJQ E;  3CKF A;  3G4S E;  3OW2 E;  3CCM E;  5GAD G;  3CKG A;  4WFA E;  5MLC H; 
#chains in the Genus database with same CATH homology
 3I56 E;  1Q82 G;  5JVH E;  1M1K G;  5GAH G;  1Q7Y G;  3CC4 E;  4IOA E;  5GAG G;  5GAE G;  1KC8 G;  4WF9 E;  3CXC E;  1K9M G;  1QVF E;  3G6E E;  1S72 E;  1KQS E;  1VQL E;  3PIP E;  1M90 G;  2QEX E;  1YJN E;  3CCR E;  3CC7 E;  4IOC E;  5DM7 E;  2ZJR E;  4U67 E;  5AN9 B;  2OTL E;  1YIJ E;  3CCE E;  1VQ9 E;  3CCL E;  1Q81 G;  4WCE E;  2CQL A;  3CC2 E;  4WFN E;  1JJ2 E;  1YJW E;  1QVG E;  3DLL E;  1YHQ E;  1YIT E;  1YI2 E;  5DM6 E;  4WFB E;  3CCU E;  3CD6 E;  3PIO E;  1VQP E;  1W2B E;  5MLC H;  3CCJ E;  3J7Z G;  1VQ7 E;  4UY8 G;  1VQN E;  3G71 E;  1VQ5 E;  3CF5 E;  1KD1 G;  2QA4 E;  1VQ8 E;  1Q86 G;  5HL7 E;  5H1S I;  3CPW E;  3CMA E;  3CCS E;  1VQK E;  3I55 E;  5JVG E;  4IO9 E;  2ZJP E;  1RL6 A;  1YJ9 E;  1K73 G;  1NJI G;  1VQ4 E;  1K8A G;  3CME E;  1VQM E;  3CCV E;  1VQO E;  2OTJ E;  3CCQ E;  1VQ6 E;  2ZJQ E;  3G4S E;  3OW2 E;  3CCM E;  5GAD G;  4WFA E;  1N8R G; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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