1YHQW

Crystal structure of azithromycin bound to the g2099a mutant 50s ribosomal subunit of haloarcula marismortui
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
154
structure length
154
Chain Sequence
MHALVQLRGEVNMHTDIQDTLEMLNIHHVNHCTLVPETDAYRGMVAKVNDFVAFGEPSQETLETVLATRAEPLEGDADVDDEWVAEHTDYDDISGLAFALLSEETTLREQGLSPTLRLHPPRGGHDGVKHPVKEGGQLGKHDTEGIDDLLEAMR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance.
pubmed doi rcsb
molecule tags Ribosome
molecule keywords 23S Ribosomal RNA
total genus 50
structure length 154
sequence length 154
ec nomenclature
pdb deposition date 2005-01-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
W PF00327 Ribosomal_L30 Ribosomal protein L30p/L7e
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.15.30 Mainly Alpha Orthogonal Bundle 3-methyladenine DNA Glycosylase II; Chain A, domain 3 3-methyladenine DNA Glycosylase II; Chain A, domain 3 1yhqW02
3.30.1390.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein L30; Chain: A, Ribosomal protein L30, ferredoxin-like fold domain 1yhqW01
1YI2W 1BXYA 1QVGV 3CC2W 2OTLW 3J7ZZ 3CC4W 1VQ5W 4IOAW 2OTJW 4IOCW 1K73X 5JVHW 1YIJW 3PIPW 5GAEa 5GAHa 4IO9W 1M90X 2ZJQW 1YHQW 1VQLW 5HL7W 1M1KX 3CCLW 4WCEW 1VQ6W 1NJIX 3G6EW 4WFNW 3PIOW 3OW2V 5GADa 2QA4W 3G71W 5GAGa 1K9MX 3G4SW 1KC8X 2QEXW 5DM6W 3I56W 1VQ7W 3CCSW 1Q86X 1K8AX 3CXCV 4WFBW 1VQOW 3I55W 4UY8Z 3CC7W 1JJ2V 3CCQW 3CCUW 1VQKW 1KD1X 1YITW 1Q82X 3CCMW 2ZJRW 3CCVW 1VQNW 3CCEW 4WF9W 1YJWW 1N8RX 3CCJW 4WFAW 2ZJPW 1Q81X 1YJ9W 1VQPW 1S72W 1YJNW 1KQSV 5JVGW 1VQ8W 1Q7YX 1QVFV 3CPWV 3CMAW 3CF5W 1W2BV 3DLLW 3CD6W 1VQ9W 3CCRW 3CMEW 4U67W 5DM7W 1VQ4W 1VQMW
chains in the Genus database with same CATH superfamily
1YI2W 1BXYA 1QVGV 3CC2W 2OTLW 1LZWA 3O2OA 3J7ZZ 3CC4W 1VQ5W 4IOAW 2OTJW 4IOCW 1K73X 5JVHW 1YIJW 4BL2A 3PIPW 3G19A 3G3PA 5GAEa 3GW1A 4YJXA 5GAHa 3D3IA 5M18A 4IO9W 1M90X 2ZJQW 1YHQW 1VQLW 5HL7W 3GQ1A 1M1KX 2W9RA 3CCLW 4WCEW 1DD4A 1MBUC 3O2BA 2WA8A 1VQ6W 1NJIX 3G6EW 4WFNW 3PIOW 5M19A 1R6QC 3OW2V 1RQUA 5M1AA 5GADa 2QA4W 3G71W 3W7TA 5GAGa 1K9MX 3G4SW 3O1FA 1KC8X 2QEXW 1MWUA 5DM6W 1MWSA 3I56W 4CJNA 1VQ7W 1RQVA 3DNJA 3W7SA 3CCSW 1Q86X 1K8AX 1CTFA 1RQSA 3ZFZA 3W7WA 3CXCV 4WFBW 2WA9A 1VQOW 3I55W 4UY8Z 3CC7W 1JJ2V 3CCQW 4YJMA 3W7XA 1MWRA 3CCUW 1VQKW 3O2HA 4BL3A 1KD1X 1YITW 4DKIA 1Q82X 3CCMW 1MBXC 2ZJRW 3CCVW 1VQNW 3GQ0A 4C1NA 3W7UA 3CCEW 4WF9W 1YJWW 1N8RX 1MWTA 3CCJW 4WFAW 2ZJPW 1Q81X 1R6OC 1YJ9W 3ZG0A 1VQQA 1DD3A 1VQPW 1S72W 3O1FB 1YJNW 1KQSV 3ZG5A 5JVGW 1VQ8W 1Q7YX 1QVFV 3CPWV 5CA3A 3CMAW 3CF5W 1W2BV 5GW7A 3DLLW 3CD6W 1VQ9W 1MBVB 4YKAA 3CCRW 4CPKA 3CMEW 4U67W 3G1BA 5DM7W 1VQ4W 1MG9A 1VQMW
chains in the Genus database with same CATH topology
1YI2W 1BXYA 1QVGV 3CC2W 2OTLW 3J7ZZ 3CC4W 1VQ5W 4IOAW 2OTJW 4IOCW 1K73X 5JVHW 1YIJW 3PIPW 5GAEa 5GAHa 4IO9W 1M90X 2ZJQW 1YHQW 1VQLW 5HL7W 1M1KX 3CCLW 4WCEW 1VQ6W 1NJIX 3G6EW 4WFNW 3PIOW 3OW2V 5GADa 2QA4W 3G71W 5GAGa 1K9MX 3G4SW 1KC8X 2QEXW 5DM6W 3I56W 1VQ7W 3CCSW 1Q86X 1K8AX 3CXCV 4WFBW 1VQOW 3I55W 4UY8Z 3CC7W 1JJ2V 3CCQW 3CCUW 1VQKW 1KD1X 1YITW 1Q82X 3CCMW 2ZJRW 3CCVW 1VQNW 4C1NA 3CCEW 4WF9W 1YJWW 1N8RX 3CCJW 4WFAW 2ZJPW 1Q81X 1YJ9W 1VQPW 1S72W 1YJNW 1KQSV 5JVGW 1VQ8W 1Q7YX 1QVFV 3CPWV 3CMAW 3CF5W 1W2BV 3DLLW 3CD6W 1VQ9W 3CCRW 3CMEW 4U67W 5DM7W 1VQ4W 1VQMW
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YI2 W;  1BXY A;  1QVG V;  3CC2 W;  2OTL W;  3J7Z Z;  3CC4 W;  1VQ5 W;  4IOA W;  2OTJ W;  4IOC W;  1K73 X;  5JVH W;  1YIJ W;  3PIP W;  5GAE a;  5GAH a;  4IO9 W;  1M90 X;  2ZJQ W;  1YHQ W;  1VQL W;  5HL7 W;  1M1K X;  3CCL W;  4WCE W;  1VQ6 W;  1NJI X;  3G6E W;  4WFN W;  3PIO W;  3OW2 V;  5GAD a;  2QA4 W;  3G71 W;  5GAG a;  1K9M X;  3G4S W;  1KC8 X;  2QEX W;  5DM6 W;  3I56 W;  1VQ7 W;  3CCS W;  1Q86 X;  1K8A X;  3CXC V;  4WFB W;  1VQO W;  3I55 W;  4UY8 Z;  3CC7 W;  1JJ2 V;  3CCQ W;  3CCU W;  1VQK W;  1KD1 X;  1YIT W;  1Q82 X;  3CCM W;  2ZJR W;  3CCV W;  1VQN W;  3CCE W;  4WF9 W;  1YJW W;  1N8R X;  3CCJ W;  4WFA W;  2ZJP W;  1Q81 X;  1YJ9 W;  1VQP W;  1S72 W;  1YJN W;  1KQS V;  5JVG W;  1VQ8 W;  1Q7Y X;  1QVF V;  3CPW V;  3CMA W;  3CF5 W;  1W2B V;  3DLL W;  3CD6 W;  1VQ9 W;  3CCR W;  3CME W;  4U67 W;  5DM7 W;  1VQ4 W;  1VQM W; 
#chains in the Genus database with same CATH topology
 1YI2 W;  1BXY A;  1QVG V;  3CC2 W;  2OTL W;  1LZW A;  3O2O A;  3J7Z Z;  3CC4 W;  1VQ5 W;  4IOA W;  2OTJ W;  4IOC W;  1K73 X;  5JVH W;  1YIJ W;  4BL2 A;  3PIP W;  3G19 A;  3G3P A;  5GAE a;  3GW1 A;  4YJX A;  5GAH a;  3D3I A;  5M18 A;  4IO9 W;  1M90 X;  2ZJQ W;  1YHQ W;  1VQL W;  5HL7 W;  3GQ1 A;  1M1K X;  2W9R A;  3CCL W;  4WCE W;  1DD4 A;  1MBU C;  3O2B A;  2WA8 A;  1VQ6 W;  1NJI X;  3G6E W;  4WFN W;  3PIO W;  5M19 A;  1R6Q C;  3OW2 V;  1RQU A;  5M1A A;  5GAD a;  2QA4 W;  3G71 W;  3W7T A;  5GAG a;  1K9M X;  3G4S W;  3O1F A;  1KC8 X;  2QEX W;  1MWU A;  5DM6 W;  1MWS A;  3I56 W;  4CJN A;  1VQ7 W;  1RQV A;  3DNJ A;  3W7S A;  3CCS W;  1Q86 X;  1K8A X;  1CTF A;  1RQS A;  3ZFZ A;  3W7W A;  3CXC V;  4WFB W;  2WA9 A;  1VQO W;  3I55 W;  4UY8 Z;  3CC7 W;  1JJ2 V;  3CCQ W;  4YJM A;  3W7X A;  1MWR A;  3CCU W;  1VQK W;  3O2H A;  4BL3 A;  1KD1 X;  1YIT W;  4DKI A;  1Q82 X;  3CCM W;  1MBX C;  2ZJR W;  3CCV W;  1VQN W;  3GQ0 A;  4C1N A;  3W7U A;  3CCE W;  4WF9 W;  1YJW W;  1N8R X;  1MWT A;  3CCJ W;  4WFA W;  2ZJP W;  1Q81 X;  1R6O C;  1YJ9 W;  3ZG0 A;  1VQQ A;  1DD3 A;  1VQP W;  1S72 W;  3O1F B;  1YJN W;  1KQS V;  3ZG5 A;  5JVG W;  1VQ8 W;  1Q7Y X;  1QVF V;  3CPW V;  5CA3 A;  3CMA W;  3CF5 W;  1W2B V;  5GW7 A;  3DLL W;  3CD6 W;  1VQ9 W;  1MBV B;  4YKA A;  3CCR W;  4CPK A;  3CME W;  4U67 W;  3G1B A;  5DM7 W;  1VQ4 W;  1MG9 A;  1VQM W; 
#chains in the Genus database with same CATH homology
 1YI2 W;  1BXY A;  1QVG V;  3CC2 W;  2OTL W;  3J7Z Z;  3CC4 W;  1VQ5 W;  4IOA W;  2OTJ W;  4IOC W;  1K73 X;  5JVH W;  1YIJ W;  3PIP W;  5GAE a;  5GAH a;  4IO9 W;  1M90 X;  2ZJQ W;  1YHQ W;  1VQL W;  5HL7 W;  1M1K X;  3CCL W;  4WCE W;  1VQ6 W;  1NJI X;  3G6E W;  4WFN W;  3PIO W;  3OW2 V;  5GAD a;  2QA4 W;  3G71 W;  5GAG a;  1K9M X;  3G4S W;  1KC8 X;  2QEX W;  5DM6 W;  3I56 W;  1VQ7 W;  3CCS W;  1Q86 X;  1K8A X;  3CXC V;  4WFB W;  1VQO W;  3I55 W;  4UY8 Z;  3CC7 W;  1JJ2 V;  3CCQ W;  3CCU W;  1VQK W;  1KD1 X;  1YIT W;  1Q82 X;  3CCM W;  2ZJR W;  3CCV W;  1VQN W;  4C1N A;  3CCE W;  4WF9 W;  1YJW W;  1N8R X;  3CCJ W;  4WFA W;  2ZJP W;  1Q81 X;  1YJ9 W;  1VQP W;  1S72 W;  1YJN W;  1KQS V;  5JVG W;  1VQ8 W;  1Q7Y X;  1QVF V;  3CPW V;  3CMA W;  3CF5 W;  1W2B V;  3DLL W;  3CD6 W;  1VQ9 W;  3CCR W;  3CME W;  4U67 W;  5DM7 W;  1VQ4 W;  1VQM W; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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