1YSIA

Solution structure of the anti-apoptotic protein bcl-xl in complex with an acyl-sulfonamide-based ligand
Total Genus 35
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
35
sequence length
181
structure length
181
Chain Sequence
MSMAMSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERLEHHHHHH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Apoptosis
molecule keywords Apoptosis regulator Bcl-X
publication title An inhibitor of Bcl-2 family proteins induces regression of solid tumours
pubmed doi rcsb
source organism Homo sapiens
total genus 35
structure length 181
sequence length 181
ec nomenclature
pdb deposition date 2005-02-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00452 Bcl-2 Apoptosis regulator proteins, Bcl-2 family
A PF02180 BH4 Bcl-2 homology region 4
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.437.10 Mainly Alpha Orthogonal Bundle Apoptosis Regulator Bcl-x Blc2-like 1ysiA00
2RODA 2YV6A 1O0LA 2JCNA 4YJ4A 3DVUA 4K5BC 4S0PA 1GJHA 2BIDA 5KTGA 4U2VA 2ROCA 4QVXA 3I1HA 1DDBA 4ZIGA 2W3LA 2WH6A 4QNQA 3KJ1A 3WIXA 2VOGA 1YSGA 1YSNA 4ZIFA 2O2FA 4BPIA 1R2EA 1PQ1A 4OYDA 1G5JA 5IEZA 1YSIA 2NLAA 1G5MA 3IHDA 1TY4A 2LR1A 3QBRA 5KU9A 3MQPA 5C3FA 1MK3A 2B48A 1WSXA 2A5YA 2JM6B 4OQ5A 1R2DA 4HW3A 2BZWA 1LXLA 3IO9A 2MHSA 3MK8A 2O2MA 4WMRA 2VOHA 3KJ2A 2O22A 4G35A 1BXLA 3IHCA 5JSBA 2VOFA 4BD8A 2ABOA 4BD2A 3WIYA 3BL2A 2VOIA 4S0OA 4HW4A 4OQ6A 4HW2A 5IF4A 2IMTA 2IMSA 2K7WA 3IHEA 3KJ0A 2PQKA 4ZBFA 3CVAX 5FC4A 1AF3A 2VM6A 1F16A 1PQ0A 4ZIEA 1Q59A 1YSWA 1R2IA 2XPXA 2ME8A 1OHUA 2O2NA 4BDUA 2MEJA 1K3KA 3ILCA 2KUAA 4ZEQA 4MI8A 4ZIHA 3PK1A 3IIGA 1ZY3A 2KBWA 4BD6A 1R2GA 2O21A 4ZBIA 4YK9A 3KZ0A 3IIHA 4BD7A 5FDOA 5FMIA 4ZIIA 4BPJA 2M5BA 1R2HA 3D7VA 2XA0A 4U2UA 5FDRA 4B4SA 2NL9A 2V6QA 1MAZA 5C6HA
chains in the Genus database with same CATH superfamily
2RODA 2YV6A 1O0LA 2VTYA 2JCNA 4YJ4A 3DVUA 4K5BC 4S0PA 1GJHA 2BIDA 5KTGA 4U2VA 2ROCA 4QVXA 3I1HA 1DDBA 2I39A 4ZIGA 2W3LA 2WH6A 4QNQA 3KJ1A 3WIXA 2VOGA 1YSGA 1YSNA 4ZIFA 2O2FA 4BPIA 1R2EA 1PQ1A 4OYDA 1G5JA 5IEZA 1YSIA 2NLAA 1G5MA 3IHDA 3JRVA 4D2LA 2JBXA 1TY4A 2LR1A 3QBRA 5KU9A 3MQPA 5C3FA 1MK3A 2B48A 1WSXA 2A5YA 2JM6B 4LQKA 4OQ5A 1R2DA 2VVWA 2BZWA 4HW3A 5C6HA 1LXLA 3IO9A 2MHSA 4UF2A 4BBDA 3MK8A 2O2MA 4WMRA 2VVXA 2VOHA 3KJ2A 2O22A 4G35A 1BXLA 3IHCA 5JSBA 2VOFA 4M0SA 2ABOA 4BD8A 4BD2A 3WIYA 3BL2A 2VOIA 4S0OA 4HW4A 4OQ6A 4HW2A 5IF4A 2IMTA 2IMSA 2K7WA 3IHEA 3KJ0A 2PQKA 4ZBFA 4UF3A 3CVAX 5FC4A 1AF3A 2K36A 2VM6A 1F16A 1PQ0A 2O42A 4ZIEA 1Q59A 1YSWA 1R2IA 2XPXA 2ME8A 1OHUA 2O2NA 4BDUA 2MEJA 1K3KA 3ILCA 2KUAA 4ZEQA 4MI8A 4UF1A 4ZIHA 3PK1A 3IIGA 1ZY3A 2KBWA 4BD6A 1R2GA 2O21A 4ZBIA 4YK9A 3KZ0A 2VVYA 3IIHA 4BD7A 5FDOA 2JBYA 5FMIA 4ZIIA 4BPJA 2M5BA 1R2HA 4D2MA 3D7VA 2XA0A 2UXEA 4U2UA 4BBBA 5FDRA 4B4SA 2NL9A 2V6QA 1MAZA 4BBCA
chains in the Genus database with same CATH topology
2RODA 2YV6A 1O0LA 2JCNA 4YJ4A 3DVUA 4K5BC 4S0PA 1GJHA 2BIDA 5KTGA 4U2VA 2ROCA 4QVXA 3I1HA 1DDBA 4ZIGA 2W3LA 2WH6A 4QNQA 3KJ1A 3WIXA 2VOGA 1YSGA 1YSNA 4ZIFA 2O2FA 4BPIA 1R2EA 1PQ1A 4OYDA 1G5JA 5IEZA 1YSIA 2NLAA 1G5MA 3IHDA 1TY4A 2LR1A 3QBRA 5KU9A 3MQPA 5C3FA 1MK3A 2B48A 1WSXA 2A5YA 2JM6B 4OQ5A 1R2DA 4HW3A 2BZWA 1LXLA 3IO9A 2MHSA 3MK8A 2O2MA 4WMRA 2VOHA 3KJ2A 2O22A 4G35A 1BXLA 3IHCA 5JSBA 2VOFA 4BD8A 2ABOA 4BD2A 3WIYA 3BL2A 2VOIA 4S0OA 4HW4A 4OQ6A 4HW2A 5IF4A 2IMTA 2IMSA 2K7WA 3IHEA 3KJ0A 2PQKA 4ZBFA 3CVAX 5FC4A 1AF3A 2VM6A 1F16A 1PQ0A 4ZIEA 1Q59A 1YSWA 1R2IA 2XPXA 2ME8A 1OHUA 2O2NA 4BDUA 2MEJA 1K3KA 3ILCA 2KUAA 4ZEQA 4MI8A 4ZIHA 3PK1A 3IIGA 1ZY3A 2KBWA 4BD6A 1R2GA 2O21A 4ZBIA 4YK9A 3KZ0A 3IIHA 4BD7A 5FDOA 5FMIA 4ZIIA 4BPJA 2M5BA 1R2HA 3D7VA 2XA0A 4U2UA 5FDRA 4B4SA 2NL9A 2V6QA 1MAZA 5C6HA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ROD A;  2YV6 A;  1O0L A;  2JCN A;  4YJ4 A;  3DVU A;  4K5B C;  4S0P A;  1GJH A;  2BID A;  5KTG A;  4U2V A;  2ROC A;  4QVX A;  3I1H A;  1DDB A;  4ZIG A;  2W3L A;  2WH6 A;  4QNQ A;  3KJ1 A;  3WIX A;  2VOG A;  1YSG A;  1YSN A;  4ZIF A;  2O2F A;  4BPI A;  1R2E A;  1PQ1 A;  4OYD A;  1G5J A;  5IEZ A;  1YSI A;  2NLA A;  1G5M A;  3IHD A;  1TY4 A;  2LR1 A;  3QBR A;  5KU9 A;  3MQP A;  5C3F A;  1MK3 A;  2B48 A;  1WSX A;  2A5Y A;  2JM6 B;  4OQ5 A;  1R2D A;  4HW3 A;  2BZW A;  1LXL A;  3IO9 A;  2MHS A;  3MK8 A;  2O2M A;  4WMR A;  2VOH A;  3KJ2 A;  2O22 A;  4G35 A;  1BXL A;  3IHC A;  5JSB A;  2VOF A;  4BD8 A;  2ABO A;  4BD2 A;  3WIY A;  3BL2 A;  2VOI A;  4S0O A;  4HW4 A;  4OQ6 A;  4HW2 A;  5IF4 A;  2IMT A;  2IMS A;  2K7W A;  3IHE A;  3KJ0 A;  2PQK A;  4ZBF A;  3CVA X;  5FC4 A;  1AF3 A;  2VM6 A;  1F16 A;  1PQ0 A;  4ZIE A;  1Q59 A;  1YSW A;  1R2I A;  2XPX A;  2ME8 A;  1OHU A;  2O2N A;  4BDU A;  2MEJ A;  1K3K A;  3ILC A;  2KUA A;  4ZEQ A;  4MI8 A;  4ZIH A;  3PK1 A;  3IIG A;  1ZY3 A;  2KBW A;  4BD6 A;  1R2G A;  2O21 A;  4ZBI A;  4YK9 A;  3KZ0 A;  3IIH A;  4BD7 A;  5FDO A;  5FMI A;  4ZII A;  4BPJ A;  2M5B A;  1R2H A;  3D7V A;  2XA0 A;  4U2U A;  5FDR A;  4B4S A;  2NL9 A;  2V6Q A;  1MAZ A;  5C6H A; 
#chains in the Genus database with same CATH topology
 2ROD A;  2YV6 A;  1O0L A;  2VTY A;  2JCN A;  4YJ4 A;  3DVU A;  4K5B C;  4S0P A;  1GJH A;  2BID A;  5KTG A;  4U2V A;  2ROC A;  4QVX A;  3I1H A;  1DDB A;  2I39 A;  4ZIG A;  2W3L A;  2WH6 A;  4QNQ A;  3KJ1 A;  3WIX A;  2VOG A;  1YSG A;  1YSN A;  4ZIF A;  2O2F A;  4BPI A;  1R2E A;  1PQ1 A;  4OYD A;  1G5J A;  5IEZ A;  1YSI A;  2NLA A;  1G5M A;  3IHD A;  3JRV A;  4D2L A;  2JBX A;  1TY4 A;  2LR1 A;  3QBR A;  5KU9 A;  3MQP A;  5C3F A;  1MK3 A;  2B48 A;  1WSX A;  2A5Y A;  2JM6 B;  4LQK A;  4OQ5 A;  1R2D A;  2VVW A;  2BZW A;  4HW3 A;  5C6H A;  1LXL A;  3IO9 A;  2MHS A;  4UF2 A;  4BBD A;  3MK8 A;  2O2M A;  4WMR A;  2VVX A;  2VOH A;  3KJ2 A;  2O22 A;  4G35 A;  1BXL A;  3IHC A;  5JSB A;  2VOF A;  4M0S A;  2ABO A;  4BD8 A;  4BD2 A;  3WIY A;  3BL2 A;  2VOI A;  4S0O A;  4HW4 A;  4OQ6 A;  4HW2 A;  5IF4 A;  2IMT A;  2IMS A;  2K7W A;  3IHE A;  3KJ0 A;  2PQK A;  4ZBF A;  4UF3 A;  3CVA X;  5FC4 A;  1AF3 A;  2K36 A;  2VM6 A;  1F16 A;  1PQ0 A;  2O42 A;  4ZIE A;  1Q59 A;  1YSW A;  1R2I A;  2XPX A;  2ME8 A;  1OHU A;  2O2N A;  4BDU A;  2MEJ A;  1K3K A;  3ILC A;  2KUA A;  4ZEQ A;  4MI8 A;  4UF1 A;  4ZIH A;  3PK1 A;  3IIG A;  1ZY3 A;  2KBW A;  4BD6 A;  1R2G A;  2O21 A;  4ZBI A;  4YK9 A;  3KZ0 A;  2VVY A;  3IIH A;  4BD7 A;  5FDO A;  2JBY A;  5FMI A;  4ZII A;  4BPJ A;  2M5B A;  1R2H A;  4D2M A;  3D7V A;  2XA0 A;  2UXE A;  4U2U A;  4BBB A;  5FDR A;  4B4S A;  2NL9 A;  2V6Q A;  1MAZ A;  4BBC A; 
#chains in the Genus database with same CATH homology
 2ROD A;  2YV6 A;  1O0L A;  2JCN A;  4YJ4 A;  3DVU A;  4K5B C;  4S0P A;  1GJH A;  2BID A;  5KTG A;  4U2V A;  2ROC A;  4QVX A;  3I1H A;  1DDB A;  4ZIG A;  2W3L A;  2WH6 A;  4QNQ A;  3KJ1 A;  3WIX A;  2VOG A;  1YSG A;  1YSN A;  4ZIF A;  2O2F A;  4BPI A;  1R2E A;  1PQ1 A;  4OYD A;  1G5J A;  5IEZ A;  1YSI A;  2NLA A;  1G5M A;  3IHD A;  1TY4 A;  2LR1 A;  3QBR A;  5KU9 A;  3MQP A;  5C3F A;  1MK3 A;  2B48 A;  1WSX A;  2A5Y A;  2JM6 B;  4OQ5 A;  1R2D A;  4HW3 A;  2BZW A;  1LXL A;  3IO9 A;  2MHS A;  3MK8 A;  2O2M A;  4WMR A;  2VOH A;  3KJ2 A;  2O22 A;  4G35 A;  1BXL A;  3IHC A;  5JSB A;  2VOF A;  4BD8 A;  2ABO A;  4BD2 A;  3WIY A;  3BL2 A;  2VOI A;  4S0O A;  4HW4 A;  4OQ6 A;  4HW2 A;  5IF4 A;  2IMT A;  2IMS A;  2K7W A;  3IHE A;  3KJ0 A;  2PQK A;  4ZBF A;  3CVA X;  5FC4 A;  1AF3 A;  2VM6 A;  1F16 A;  1PQ0 A;  4ZIE A;  1Q59 A;  1YSW A;  1R2I A;  2XPX A;  2ME8 A;  1OHU A;  2O2N A;  4BDU A;  2MEJ A;  1K3K A;  3ILC A;  2KUA A;  4ZEQ A;  4MI8 A;  4ZIH A;  3PK1 A;  3IIG A;  1ZY3 A;  2KBW A;  4BD6 A;  1R2G A;  2O21 A;  4ZBI A;  4YK9 A;  3KZ0 A;  3IIH A;  4BD7 A;  5FDO A;  5FMI A;  4ZII A;  4BPJ A;  2M5B A;  1R2H A;  3D7V A;  2XA0 A;  4U2U A;  5FDR A;  4B4S A;  2NL9 A;  2V6Q A;  1MAZ A;  5C6H A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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