1ZEBA

X-ray structure of alkaline phosphatase from human placenta in complex with 5'-amp
Total Genus 173
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
173
Knots found
sequence length
480
structure length
479
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus 173
structure length 479
sequence length 480
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2005-04-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1zebA00
4UPHA 2G9YA 3IGYB 3LXQA 3DPCA 1ELYA 1ALHA 2W5TA 1Y6VA 4FDIA 1URAA 4KJDA 2GA3A 1E1ZP 1KHNA 4KM4A 4UPIA 5DLVA 4KAVA 3IDDA 5GOVA 1KH9A 3UO0A 1SHQA 3TX0A 3M8WA 4LRBA 3DYCA 4CYRA 3WAXA 2W5XA 1O99A 4CXUA 4B56A 1KHLA 5C66A 2ZKTA 1AJBA 5HRTA 5AJ9A 1EI6A 5EGEA 5GRRA 4UOPA 3TG0A 2W5VA 1EW2A 1ZEDA 2QZUA 4N7TA 4UORA 4CXKA 4NWXA 2W5RA 4LREA 2D1GA 3MK0A 3M7VA 5LQQA 1FSUA 1E33P 1N2LA 2W5SA 3M8YA 4MY4A 3WAYA 4YR1A 1KH4A 1EW8A 2GSOA 5K4PA 1URBA 1EQJA 1ALJA 3M8ZA 1ELZA 2W5QA 3UN3A 5EGHA 1AJDA 1ZEBA 2VQRA 1KH5A 3Q3QA 4KJGA 3MK1A 3MK2A 3CMRA 3NKRA 3OT9A 1Y7AA 5LRNA 2W8DA 4GTZA 4UPLA 1ALIA 1E2SP 1AJCA 3BDGB 1ELXA 4UOOA 4LRFA 5L0EA 1SHNA 1ZEFA 3UNYA 3B5QA 3BDGA 4LR9A 5INHA 1B8JA 4LR7A 3E2DA 4GTWA 2IUCB 5DLTA 1ANJA 2GLQA 3NVLA 4UPKA 5L0KA 2W5WA 4LR8A 5LRMA 2IFYA 4ZGAA 2W8SA 4NWJA 4ZG6A 5L0BA 2ANHA 3BDFA 4CXSA 1E3CP 3NKMA 5DLWA 1K7HA 3BDHA 5LIAA 1AJAA 4CYSA 3KD8A 2RH6A 1KHKA 1O98A 1P49A 2XRGA 4GTYA 4ZG7A 1N2KA 3WAWA 3NKOA 3T00A 4TN0A 4LRCA 1KHJA 4ZG9A 4FDJA 3NKPA 1ED8A 3NKNA 1AUKA 2IUCA 4LRDA 4GTXA 5IJSA 2X98A 1KH7A 3UN2A 1HDHA 4KAYA 5TJ3A 3TWZA 1ALKA 1ED9A 4MHXA 1HQAA 1EW9A 3SZYA 4LR2A 1HJKA 2XR9A 3WAVA 3A52A 4MIVA 3IGZB 1EJJA 4QAXA 3UN5A 5KXAA 4LRAA 1ANIA 3SZZA 2GSUA 3WBHA 3T02A 2GSNA 4LQYA 3T01A 5IJQA 3ED4A 3NKQA
chains in the Genus database with same CATH superfamily
4UPHA 2G9YA 3IGYB 3LXQA 3DPCA 1ELYA 1ALHA 2W5TA 1Y6VA 4FDIA 1URAA 4KJDA 2GA3A 1E1ZP 1KHNA 4KM4A 4UPIA 5DLVA 4KAVA 3IDDA 5GOVA 1KH9A 3UO0A 1SHQA 3TX0A 3M8WA 4LRBA 3DYCA 4CYRA 3WAXA 2W5XA 1O99A 4CXUA 4B56A 1KHLA 5C66A 2ZKTA 1AJBA 5HRTA 5AJ9A 1EI6A 5EGEA 5GRRA 4UOPA 3TG0A 2W5VA 1EW2A 1ZEDA 2QZUA 4N7TA 4UORA 4CXKA 4NWXA 2W5RA 4LREA 2D1GA 3MK0A 3M7VA 5LQQA 1FSUA 1E33P 1N2LA 2W5SA 3M8YA 4MY4A 3WAYA 4YR1A 1KH4A 1EW8A 2GSOA 5K4PA 1URBA 1EQJA 1ALJA 3M8ZA 1ELZA 2W5QA 3UN3A 5EGHA 1AJDA 1ZEBA 2VQRA 1KH5A 3Q3QA 4KJGA 3MK1A 3MK2A 3CMRA 3NKRA 3OT9A 1Y7AA 5LRNA 2W8DA 4GTZA 4UPLA 1ALIA 1E2SP 1AJCA 3BDGB 1ELXA 4UOOA 4LRFA 5L0EA 1SHNA 1ZEFA 3UNYA 3B5QA 3BDGA 4LR9A 5INHA 1B8JA 4LR7A 3E2DA 4GTWA 2IUCB 5DLTA 1ANJA 2GLQA 3NVLA 4UPKA 5L0KA 2W5WA 4LR8A 5LRMA 2IFYA 4ZGAA 2W8SA 4NWJA 4ZG6A 5L0BA 2ANHA 3BDFA 4CXSA 1E3CP 3NKMA 5DLWA 1K7HA 3BDHA 5LIAA 1AJAA 4CYSA 3KD8A 2RH6A 1KHKA 1O98A 1P49A 2XRGA 4GTYA 4ZG7A 1N2KA 3WAWA 3NKOA 3T00A 4TN0A 4LRCA 1KHJA 4ZG9A 4FDJA 3NKPA 1ED8A 3NKNA 1AUKA 2IUCA 4LRDA 4GTXA 5IJSA 2X98A 1KH7A 3UN2A 1HDHA 4KAYA 5TJ3A 3TWZA 1ALKA 1ED9A 4MHXA 1HQAA 1EW9A 3SZYA 4LR2A 1HJKA 2XR9A 3WAVA 3A52A 4MIVA 3IGZB 1EJJA 4QAXA 3UN5A 5KXAA 4LRAA 1ANIA 3SZZA 2GSUA 3WBHA 3T02A 2GSNA 4LQYA 3T01A 5IJQA 3ED4A 3NKQA
chains in the Genus database with same CATH topology
4UPHA 2G9YA 3IGYB 3LXQA 3DPCA 1ELYA 1ALHA 2W5TA 1Y6VA 4FDIA 1URAA 4KJDA 2GA3A 1E1ZP 1KHNA 4KM4A 4UPIA 5DLVA 4KAVA 3IDDA 5GOVA 1KH9A 3UO0A 1SHQA 3TX0A 3M8WA 4LRBA 3DYCA 4CYRA 3WAXA 2W5XA 1O99A 4CXUA 4B56A 1KHLA 5C66A 2ZKTA 1AJBA 5HRTA 5AJ9A 1EI6A 5EGEA 5GRRA 4UOPA 3TG0A 2W5VA 1EW2A 1ZEDA 2QZUA 4N7TA 4UORA 4CXKA 4NWXA 2W5RA 4LREA 2D1GA 3MK0A 3M7VA 5LQQA 1FSUA 1E33P 1N2LA 2W5SA 3M8YA 4MY4A 3WAYA 4YR1A 1KH4A 1EW8A 2GSOA 5K4PA 1URBA 1EQJA 1ALJA 3M8ZA 1ELZA 2W5QA 3UN3A 5EGHA 1AJDA 1ZEBA 2VQRA 1KH5A 3Q3QA 4KJGA 3MK1A 3MK2A 3CMRA 3NKRA 3OT9A 1Y7AA 5LRNA 2W8DA 4GTZA 4UPLA 1ALIA 1E2SP 1AJCA 3BDGB 1ELXA 4UOOA 4LRFA 5L0EA 1SHNA 1ZEFA 3UNYA 3B5QA 3BDGA 4LR9A 5INHA 1B8JA 4LR7A 3E2DA 4GTWA 2IUCB 5DLTA 1ANJA 2GLQA 3NVLA 4UPKA 5L0KA 2W5WA 4LR8A 5LRMA 2IFYA 4ZGAA 2W8SA 4NWJA 4ZG6A 5L0BA 2ANHA 3BDFA 4CXSA 1E3CP 3NKMA 5DLWA 1K7HA 3BDHA 5LIAA 1AJAA 4CYSA 3KD8A 2RH6A 1KHKA 1O98A 1P49A 2XRGA 4GTYA 4ZG7A 1N2KA 3WAWA 3NKOA 3T00A 4TN0A 4LRCA 1KHJA 4ZG9A 4FDJA 3NKPA 1ED8A 3NKNA 1AUKA 2IUCA 4LRDA 4GTXA 5IJSA 2X98A 1KH7A 3UN2A 1HDHA 4KAYA 5TJ3A 3TWZA 1ALKA 1ED9A 4MHXA 1HQAA 1EW9A 3SZYA 4LR2A 1HJKA 2XR9A 3WAVA 3A52A 4MIVA 3IGZB 1EJJA 4QAXA 3UN5A 5KXAA 4LRAA 1ANIA 3SZZA 2GSUA 3WBHA 3T02A 2GSNA 4LQYA 3T01A 5IJQA 3ED4A 3NKQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4UPH A;  2G9Y A;  3IGY B;  3LXQ A;  3DPC A;  1ELY A;  1ALH A;  2W5T A;  1Y6V A;  4FDI A;  1URA A;  4KJD A;  2GA3 A;  1E1Z P;  1KHN A;  4KM4 A;  4UPI A;  5DLV A;  4KAV A;  3IDD A;  5GOV A;  1KH9 A;  3UO0 A;  1SHQ A;  3TX0 A;  3M8W A;  4LRB A;  3DYC A;  4CYR A;  3WAX A;  2W5X A;  1O99 A;  4CXU A;  4B56 A;  1KHL A;  5C66 A;  2ZKT A;  1AJB A;  5HRT A;  5AJ9 A;  1EI6 A;  5EGE A;  5GRR A;  4UOP A;  3TG0 A;  2W5V A;  1EW2 A;  1ZED A;  2QZU A;  4N7T A;  4UOR A;  4CXK A;  4NWX A;  2W5R A;  4LRE A;  2D1G A;  3MK0 A;  3M7V A;  5LQQ A;  1FSU A;  1E33 P;  1N2L A;  2W5S A;  3M8Y A;  4MY4 A;  3WAY A;  4YR1 A;  1KH4 A;  1EW8 A;  2GSO A;  5K4P A;  1URB A;  1EQJ A;  1ALJ A;  3M8Z A;  1ELZ A;  2W5Q A;  3UN3 A;  5EGH A;  1AJD A;  1ZEB A;  2VQR A;  1KH5 A;  3Q3Q A;  4KJG A;  3MK1 A;  3MK2 A;  3CMR A;  3NKR A;  3OT9 A;  1Y7A A;  5LRN A;  2W8D A;  4GTZ A;  4UPL A;  1ALI A;  1E2S P;  1AJC A;  3BDG B;  1ELX A;  4UOO A;  4LRF A;  5L0E A;  1SHN A;  1ZEF A;  3UNY A;  3B5Q A;  3BDG A;  4LR9 A;  5INH A;  1B8J A;  4LR7 A;  3E2D A;  4GTW A;  2IUC B;  5DLT A;  1ANJ A;  2GLQ A;  3NVL A;  4UPK A;  5L0K A;  2W5W A;  4LR8 A;  5LRM A;  2IFY A;  4ZGA A;  2W8S A;  4NWJ A;  4ZG6 A;  5L0B A;  2ANH A;  3BDF A;  4CXS A;  1E3C P;  3NKM A;  5DLW A;  1K7H A;  3BDH A;  5LIA A;  1AJA A;  4CYS A;  3KD8 A;  2RH6 A;  1KHK A;  1O98 A;  1P49 A;  2XRG A;  4GTY A;  4ZG7 A;  1N2K A;  3WAW A;  3NKO A;  3T00 A;  4TN0 A;  4LRC A;  1KHJ A;  4ZG9 A;  4FDJ A;  3NKP A;  1ED8 A;  3NKN A;  1AUK A;  2IUC A;  4LRD A;  4GTX A;  5IJS A;  2X98 A;  1KH7 A;  3UN2 A;  1HDH A;  4KAY A;  5TJ3 A;  3TWZ A;  1ALK A;  1ED9 A;  4MHX A;  1HQA A;  1EW9 A;  3SZY A;  4LR2 A;  1HJK A;  2XR9 A;  3WAV A;  3A52 A;  4MIV A;  3IGZ B;  1EJJ A;  4QAX A;  3UN5 A;  5KXA A;  4LRA A;  1ANI A;  3SZZ A;  2GSU A;  3WBH A;  3T02 A;  2GSN A;  4LQY A;  3T01 A;  5IJQ A;  3ED4 A;  3NKQ A; 
#chains in the Genus database with same CATH topology
 4UPH A;  2G9Y A;  3IGY B;  3LXQ A;  3DPC A;  1ELY A;  1ALH A;  2W5T A;  1Y6V A;  4FDI A;  1URA A;  4KJD A;  2GA3 A;  1E1Z P;  1KHN A;  4KM4 A;  4UPI A;  5DLV A;  4KAV A;  3IDD A;  5GOV A;  1KH9 A;  3UO0 A;  1SHQ A;  3TX0 A;  3M8W A;  4LRB A;  3DYC A;  4CYR A;  3WAX A;  2W5X A;  1O99 A;  4CXU A;  4B56 A;  1KHL A;  5C66 A;  2ZKT A;  1AJB A;  5HRT A;  5AJ9 A;  1EI6 A;  5EGE A;  5GRR A;  4UOP A;  3TG0 A;  2W5V A;  1EW2 A;  1ZED A;  2QZU A;  4N7T A;  4UOR A;  4CXK A;  4NWX A;  2W5R A;  4LRE A;  2D1G A;  3MK0 A;  3M7V A;  5LQQ A;  1FSU A;  1E33 P;  1N2L A;  2W5S A;  3M8Y A;  4MY4 A;  3WAY A;  4YR1 A;  1KH4 A;  1EW8 A;  2GSO A;  5K4P A;  1URB A;  1EQJ A;  1ALJ A;  3M8Z A;  1ELZ A;  2W5Q A;  3UN3 A;  5EGH A;  1AJD A;  1ZEB A;  2VQR A;  1KH5 A;  3Q3Q A;  4KJG A;  3MK1 A;  3MK2 A;  3CMR A;  3NKR A;  3OT9 A;  1Y7A A;  5LRN A;  2W8D A;  4GTZ A;  4UPL A;  1ALI A;  1E2S P;  1AJC A;  3BDG B;  1ELX A;  4UOO A;  4LRF A;  5L0E A;  1SHN A;  1ZEF A;  3UNY A;  3B5Q A;  3BDG A;  4LR9 A;  5INH A;  1B8J A;  4LR7 A;  3E2D A;  4GTW A;  2IUC B;  5DLT A;  1ANJ A;  2GLQ A;  3NVL A;  4UPK A;  5L0K A;  2W5W A;  4LR8 A;  5LRM A;  2IFY A;  4ZGA A;  2W8S A;  4NWJ A;  4ZG6 A;  5L0B A;  2ANH A;  3BDF A;  4CXS A;  1E3C P;  3NKM A;  5DLW A;  1K7H A;  3BDH A;  5LIA A;  1AJA A;  4CYS A;  3KD8 A;  2RH6 A;  1KHK A;  1O98 A;  1P49 A;  2XRG A;  4GTY A;  4ZG7 A;  1N2K A;  3WAW A;  3NKO A;  3T00 A;  4TN0 A;  4LRC A;  1KHJ A;  4ZG9 A;  4FDJ A;  3NKP A;  1ED8 A;  3NKN A;  1AUK A;  2IUC A;  4LRD A;  4GTX A;  5IJS A;  2X98 A;  1KH7 A;  3UN2 A;  1HDH A;  4KAY A;  5TJ3 A;  3TWZ A;  1ALK A;  1ED9 A;  4MHX A;  1HQA A;  1EW9 A;  3SZY A;  4LR2 A;  1HJK A;  2XR9 A;  3WAV A;  3A52 A;  4MIV A;  3IGZ B;  1EJJ A;  4QAX A;  3UN5 A;  5KXA A;  4LRA A;  1ANI A;  3SZZ A;  2GSU A;  3WBH A;  3T02 A;  2GSN A;  4LQY A;  3T01 A;  5IJQ A;  3ED4 A;  3NKQ A; 
#chains in the Genus database with same CATH homology
 4UPH A;  2G9Y A;  3IGY B;  3LXQ A;  3DPC A;  1ELY A;  1ALH A;  2W5T A;  1Y6V A;  4FDI A;  1URA A;  4KJD A;  2GA3 A;  1E1Z P;  1KHN A;  4KM4 A;  4UPI A;  5DLV A;  4KAV A;  3IDD A;  5GOV A;  1KH9 A;  3UO0 A;  1SHQ A;  3TX0 A;  3M8W A;  4LRB A;  3DYC A;  4CYR A;  3WAX A;  2W5X A;  1O99 A;  4CXU A;  4B56 A;  1KHL A;  5C66 A;  2ZKT A;  1AJB A;  5HRT A;  5AJ9 A;  1EI6 A;  5EGE A;  5GRR A;  4UOP A;  3TG0 A;  2W5V A;  1EW2 A;  1ZED A;  2QZU A;  4N7T A;  4UOR A;  4CXK A;  4NWX A;  2W5R A;  4LRE A;  2D1G A;  3MK0 A;  3M7V A;  5LQQ A;  1FSU A;  1E33 P;  1N2L A;  2W5S A;  3M8Y A;  4MY4 A;  3WAY A;  4YR1 A;  1KH4 A;  1EW8 A;  2GSO A;  5K4P A;  1URB A;  1EQJ A;  1ALJ A;  3M8Z A;  1ELZ A;  2W5Q A;  3UN3 A;  5EGH A;  1AJD A;  1ZEB A;  2VQR A;  1KH5 A;  3Q3Q A;  4KJG A;  3MK1 A;  3MK2 A;  3CMR A;  3NKR A;  3OT9 A;  1Y7A A;  5LRN A;  2W8D A;  4GTZ A;  4UPL A;  1ALI A;  1E2S P;  1AJC A;  3BDG B;  1ELX A;  4UOO A;  4LRF A;  5L0E A;  1SHN A;  1ZEF A;  3UNY A;  3B5Q A;  3BDG A;  4LR9 A;  5INH A;  1B8J A;  4LR7 A;  3E2D A;  4GTW A;  2IUC B;  5DLT A;  1ANJ A;  2GLQ A;  3NVL A;  4UPK A;  5L0K A;  2W5W A;  4LR8 A;  5LRM A;  2IFY A;  4ZGA A;  2W8S A;  4NWJ A;  4ZG6 A;  5L0B A;  2ANH A;  3BDF A;  4CXS A;  1E3C P;  3NKM A;  5DLW A;  1K7H A;  3BDH A;  5LIA A;  1AJA A;  4CYS A;  3KD8 A;  2RH6 A;  1KHK A;  1O98 A;  1P49 A;  2XRG A;  4GTY A;  4ZG7 A;  1N2K A;  3WAW A;  3NKO A;  3T00 A;  4TN0 A;  4LRC A;  1KHJ A;  4ZG9 A;  4FDJ A;  3NKP A;  1ED8 A;  3NKN A;  1AUK A;  2IUC A;  4LRD A;  4GTX A;  5IJS A;  2X98 A;  1KH7 A;  3UN2 A;  1HDH A;  4KAY A;  5TJ3 A;  3TWZ A;  1ALK A;  1ED9 A;  4MHX A;  1HQA A;  1EW9 A;  3SZY A;  4LR2 A;  1HJK A;  2XR9 A;  3WAV A;  3A52 A;  4MIV A;  3IGZ B;  1EJJ A;  4QAX A;  3UN5 A;  5KXA A;  4LRA A;  1ANI A;  3SZZ A;  2GSU A;  3WBH A;  3T02 A;  2GSN A;  4LQY A;  3T01 A;  5IJQ A;  3ED4 A;  3NKQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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