1ZEDA

Alkaline phosphatase from human placenta in complex with p-nitrophenyl-phosphonate
Total Genus 177
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
177
Knots found
sequence length
481
structure length
481
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase
publication title Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands.
pubmed doi rcsb
molecule tags Hydrolase
total genus 177
structure length 481
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2005-04-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1zedA00
3SZZA 2XR9A 3WAXA 3Q3QA 1EI6A 4ZG7A 3NKMA 4ZGAA 3M7VA 2X98A 3UN5A 1ZEFA 4MIVA 4LR2A 3WAWA 4KM4A 4LRAA 4CXKA 4LRFA 3NKOA 4LREA 3DPCA 2ZKTA 1ANIA 5DLVA 3NKNA 3T02A 4UOPA 5INHA 3IDDA 2QZUA 4CXSA 1KHJA 1EJJA 4GTZA 2XRGA 1O99A 3WAVA 5L0BA 4UOOA 2W5VA 2W8DA 3T01A 1N2KA 4GTWA 2IUCB 1EW9A 4KAVA 3MK1A 1AJDA 2W8SA 4UPHA 3TG0A 2GSNA 2ANHA 4B56A 5DLWA 1E1ZP 1HQAA 3BDFA 3WBHA 4LR7A 1KH5A 4FDIA 1KHLA 4FDJA 4N7TA 1ALIA 1KH4A 3T00A 1KH7A 3OT9A 4KJDA 2IFYA 4LRCA 3UO0A 5HRTA 3BDGA 3A52A 2D1GA 4UPKA 4MY4A 5IJQA 4UPLA 3MK0A 4YR1A 5TJ3A 1ANJA 1E2SP 1O98A 5EGHA 1AUKA 2W5WA 5C66A 5LRMA 2W5XA 4KAYA 3B5QA 1ALHA 1P49A 5LRNA 3NKPA 2W5TA 4CYSA 1N2LA 4QAXA 5AJ9A 1ED9A 1ALJA 1FSUA 3NKRA 3IGYB 3M8ZA 4GTXA 3NKQA 2IUCA 1EQJA 4NWJA 1KH9A 4LRDA 4NWXA 3UN3A 4LRBA 1KHKA 1URBA 2G9YA 3E2DA 3M8WA 3UNYA 5LIAA 5GRRA 3ED4A 3BDHA 4LQYA 5L0KA 4TN0A 1ED8A 5L0EA 3DYCA 1ZEDA 3NVLA 2GLQA 2VQRA 5K4PA 4CXUA 2GSUA 1SHNA 5DLTA 3LXQA 4CYRA 1HJKA 1ELZA 1B8JA 1E33P 4UPIA 1HDHA 4ZG6A 3BDGB 5KXAA 2GA3A 1K7HA 1SHQA 2W5QA 5GOVA 4ZG9A 1AJAA 4LR8A 1KHNA 2W5RA 1Y7AA 3IGZB 1ZEBA 1EW2A 2GSOA 1AJBA 4UORA 3TWZA 3WAYA 1Y6VA 5EGEA 1ELYA 1URAA 2W5SA 2RH6A 3M8YA 4GTYA 4LR9A 1ELXA 5IJSA 1ALKA 3SZYA 3TX0A 1EW8A 3KD8A 5LQQA 1E3CP 3MK2A 4KJGA 3UN2A 4MHXA 3CMRA 1AJCA
chains in the Genus database with same CATH superfamily
3SZZA 2XR9A 3WAXA 3Q3QA 1EI6A 4ZG7A 3NKMA 4ZGAA 3M7VA 2X98A 3UN5A 1ZEFA 4MIVA 4LR2A 3WAWA 4KM4A 4LRAA 4CXKA 4LRFA 3NKOA 4LREA 3DPCA 2ZKTA 1ANIA 5DLVA 3NKNA 3T02A 4UOPA 5INHA 3IDDA 2QZUA 4CXSA 1KHJA 1EJJA 4GTZA 2XRGA 1O99A 3WAVA 5L0BA 4UOOA 2W5VA 2W8DA 3T01A 1N2KA 4GTWA 2IUCB 1EW9A 4KAVA 3MK1A 1AJDA 2W8SA 4UPHA 3TG0A 2GSNA 2ANHA 4B56A 5DLWA 1E1ZP 1HQAA 3BDFA 3WBHA 4LR7A 1KH5A 4FDIA 1KHLA 4FDJA 4N7TA 1ALIA 1KH4A 3T00A 1KH7A 3OT9A 4KJDA 2IFYA 4LRCA 3UO0A 5HRTA 3BDGA 3A52A 2D1GA 4UPKA 4MY4A 5IJQA 4UPLA 3MK0A 4YR1A 5TJ3A 1ANJA 1E2SP 1O98A 5EGHA 1AUKA 2W5WA 5C66A 5LRMA 2W5XA 4KAYA 3B5QA 1ALHA 1P49A 5LRNA 3NKPA 2W5TA 4CYSA 1N2LA 4QAXA 5AJ9A 1ED9A 1ALJA 1FSUA 3NKRA 3IGYB 3M8ZA 4GTXA 3NKQA 2IUCA 1EQJA 4NWJA 1KH9A 4LRDA 4NWXA 3UN3A 4LRBA 1KHKA 1URBA 2G9YA 3E2DA 3M8WA 3UNYA 5LIAA 5GRRA 3ED4A 3BDHA 4LQYA 5L0KA 4TN0A 1ED8A 5L0EA 3DYCA 1ZEDA 3NVLA 2GLQA 2VQRA 5K4PA 4CXUA 2GSUA 1SHNA 5DLTA 3LXQA 4CYRA 1HJKA 1ELZA 1B8JA 1E33P 4UPIA 1HDHA 4ZG6A 3BDGB 5KXAA 2GA3A 1K7HA 1SHQA 2W5QA 5GOVA 4ZG9A 1AJAA 4LR8A 1KHNA 2W5RA 1Y7AA 3IGZB 1ZEBA 1EW2A 2GSOA 1AJBA 4UORA 3TWZA 3WAYA 1Y6VA 5EGEA 1ELYA 1URAA 2W5SA 2RH6A 3M8YA 4GTYA 4LR9A 1ELXA 5IJSA 1ALKA 3SZYA 3TX0A 1EW8A 3KD8A 5LQQA 1E3CP 3MK2A 4KJGA 3UN2A 4MHXA 3CMRA 1AJCA
chains in the Genus database with same CATH topology
3SZZA 2XR9A 3WAXA 3Q3QA 1EI6A 4ZG7A 3NKMA 4ZGAA 3M7VA 2X98A 3UN5A 1ZEFA 4MIVA 4LR2A 3WAWA 4KM4A 4LRAA 4CXKA 4LRFA 3NKOA 4LREA 3DPCA 2ZKTA 1ANIA 5DLVA 3NKNA 3T02A 4UOPA 5INHA 3IDDA 2QZUA 4CXSA 1KHJA 1EJJA 4GTZA 2XRGA 1O99A 3WAVA 5L0BA 4UOOA 2W5VA 2W8DA 3T01A 1N2KA 4GTWA 2IUCB 1EW9A 4KAVA 3MK1A 1AJDA 2W8SA 4UPHA 3TG0A 2GSNA 2ANHA 4B56A 5DLWA 1E1ZP 1HQAA 3BDFA 3WBHA 4LR7A 1KH5A 4FDIA 1KHLA 4FDJA 4N7TA 1ALIA 1KH4A 3T00A 1KH7A 3OT9A 4KJDA 2IFYA 4LRCA 3UO0A 5HRTA 3BDGA 3A52A 2D1GA 4UPKA 4MY4A 5IJQA 4UPLA 3MK0A 4YR1A 5TJ3A 1ANJA 1E2SP 1O98A 5EGHA 1AUKA 2W5WA 5C66A 5LRMA 2W5XA 4KAYA 3B5QA 1ALHA 1P49A 5LRNA 3NKPA 2W5TA 4CYSA 1N2LA 4QAXA 5AJ9A 1ED9A 1ALJA 1FSUA 3NKRA 3IGYB 3M8ZA 4GTXA 3NKQA 2IUCA 1EQJA 4NWJA 1KH9A 4LRDA 4NWXA 3UN3A 4LRBA 1KHKA 1URBA 2G9YA 3E2DA 3M8WA 3UNYA 5LIAA 5GRRA 3ED4A 3BDHA 4LQYA 5L0KA 4TN0A 1ED8A 5L0EA 3DYCA 1ZEDA 3NVLA 2GLQA 2VQRA 5K4PA 4CXUA 2GSUA 1SHNA 5DLTA 3LXQA 4CYRA 1HJKA 1ELZA 1B8JA 1E33P 4UPIA 1HDHA 4ZG6A 3BDGB 5KXAA 2GA3A 1K7HA 1SHQA 2W5QA 5GOVA 4ZG9A 1AJAA 4LR8A 1KHNA 2W5RA 1Y7AA 3IGZB 1ZEBA 1EW2A 2GSOA 1AJBA 4UORA 3TWZA 3WAYA 1Y6VA 5EGEA 1ELYA 1URAA 2W5SA 2RH6A 3M8YA 4GTYA 4LR9A 1ELXA 5IJSA 1ALKA 3SZYA 3TX0A 1EW8A 3KD8A 5LQQA 1E3CP 3MK2A 4KJGA 3UN2A 4MHXA 3CMRA 1AJCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3SZZ A;  2XR9 A;  3WAX A;  3Q3Q A;  1EI6 A;  4ZG7 A;  3NKM A;  4ZGA A;  3M7V A;  2X98 A;  3UN5 A;  1ZEF A;  4MIV A;  4LR2 A;  3WAW A;  4KM4 A;  4LRA A;  4CXK A;  4LRF A;  3NKO A;  4LRE A;  3DPC A;  2ZKT A;  1ANI A;  5DLV A;  3NKN A;  3T02 A;  4UOP A;  5INH A;  3IDD A;  2QZU A;  4CXS A;  1KHJ A;  1EJJ A;  4GTZ A;  2XRG A;  1O99 A;  3WAV A;  5L0B A;  4UOO A;  2W5V A;  2W8D A;  3T01 A;  1N2K A;  4GTW A;  2IUC B;  1EW9 A;  4KAV A;  3MK1 A;  1AJD A;  2W8S A;  4UPH A;  3TG0 A;  2GSN A;  2ANH A;  4B56 A;  5DLW A;  1E1Z P;  1HQA A;  3BDF A;  3WBH A;  4LR7 A;  1KH5 A;  4FDI A;  1KHL A;  4FDJ A;  4N7T A;  1ALI A;  1KH4 A;  3T00 A;  1KH7 A;  3OT9 A;  4KJD A;  2IFY A;  4LRC A;  3UO0 A;  5HRT A;  3BDG A;  3A52 A;  2D1G A;  4UPK A;  4MY4 A;  5IJQ A;  4UPL A;  3MK0 A;  4YR1 A;  5TJ3 A;  1ANJ A;  1E2S P;  1O98 A;  5EGH A;  1AUK A;  2W5W A;  5C66 A;  5LRM A;  2W5X A;  4KAY A;  3B5Q A;  1ALH A;  1P49 A;  5LRN A;  3NKP A;  2W5T A;  4CYS A;  1N2L A;  4QAX A;  5AJ9 A;  1ED9 A;  1ALJ A;  1FSU A;  3NKR A;  3IGY B;  3M8Z A;  4GTX A;  3NKQ A;  2IUC A;  1EQJ A;  4NWJ A;  1KH9 A;  4LRD A;  4NWX A;  3UN3 A;  4LRB A;  1KHK A;  1URB A;  2G9Y A;  3E2D A;  3M8W A;  3UNY A;  5LIA A;  5GRR A;  3ED4 A;  3BDH A;  4LQY A;  5L0K A;  4TN0 A;  1ED8 A;  5L0E A;  3DYC A;  1ZED A;  3NVL A;  2GLQ A;  2VQR A;  5K4P A;  4CXU A;  2GSU A;  1SHN A;  5DLT A;  3LXQ A;  4CYR A;  1HJK A;  1ELZ A;  1B8J A;  1E33 P;  4UPI A;  1HDH A;  4ZG6 A;  3BDG B;  5KXA A;  2GA3 A;  1K7H A;  1SHQ A;  2W5Q A;  5GOV A;  4ZG9 A;  1AJA A;  4LR8 A;  1KHN A;  2W5R A;  1Y7A A;  3IGZ B;  1ZEB A;  1EW2 A;  2GSO A;  1AJB A;  4UOR A;  3TWZ A;  3WAY A;  1Y6V A;  5EGE A;  1ELY A;  1URA A;  2W5S A;  2RH6 A;  3M8Y A;  4GTY A;  4LR9 A;  1ELX A;  5IJS A;  1ALK A;  3SZY A;  3TX0 A;  1EW8 A;  3KD8 A;  5LQQ A;  1E3C P;  3MK2 A;  4KJG A;  3UN2 A;  4MHX A;  3CMR A;  1AJC A; 
#chains in the Genus database with same CATH topology
 3SZZ A;  2XR9 A;  3WAX A;  3Q3Q A;  1EI6 A;  4ZG7 A;  3NKM A;  4ZGA A;  3M7V A;  2X98 A;  3UN5 A;  1ZEF A;  4MIV A;  4LR2 A;  3WAW A;  4KM4 A;  4LRA A;  4CXK A;  4LRF A;  3NKO A;  4LRE A;  3DPC A;  2ZKT A;  1ANI A;  5DLV A;  3NKN A;  3T02 A;  4UOP A;  5INH A;  3IDD A;  2QZU A;  4CXS A;  1KHJ A;  1EJJ A;  4GTZ A;  2XRG A;  1O99 A;  3WAV A;  5L0B A;  4UOO A;  2W5V A;  2W8D A;  3T01 A;  1N2K A;  4GTW A;  2IUC B;  1EW9 A;  4KAV A;  3MK1 A;  1AJD A;  2W8S A;  4UPH A;  3TG0 A;  2GSN A;  2ANH A;  4B56 A;  5DLW A;  1E1Z P;  1HQA A;  3BDF A;  3WBH A;  4LR7 A;  1KH5 A;  4FDI A;  1KHL A;  4FDJ A;  4N7T A;  1ALI A;  1KH4 A;  3T00 A;  1KH7 A;  3OT9 A;  4KJD A;  2IFY A;  4LRC A;  3UO0 A;  5HRT A;  3BDG A;  3A52 A;  2D1G A;  4UPK A;  4MY4 A;  5IJQ A;  4UPL A;  3MK0 A;  4YR1 A;  5TJ3 A;  1ANJ A;  1E2S P;  1O98 A;  5EGH A;  1AUK A;  2W5W A;  5C66 A;  5LRM A;  2W5X A;  4KAY A;  3B5Q A;  1ALH A;  1P49 A;  5LRN A;  3NKP A;  2W5T A;  4CYS A;  1N2L A;  4QAX A;  5AJ9 A;  1ED9 A;  1ALJ A;  1FSU A;  3NKR A;  3IGY B;  3M8Z A;  4GTX A;  3NKQ A;  2IUC A;  1EQJ A;  4NWJ A;  1KH9 A;  4LRD A;  4NWX A;  3UN3 A;  4LRB A;  1KHK A;  1URB A;  2G9Y A;  3E2D A;  3M8W A;  3UNY A;  5LIA A;  5GRR A;  3ED4 A;  3BDH A;  4LQY A;  5L0K A;  4TN0 A;  1ED8 A;  5L0E A;  3DYC A;  1ZED A;  3NVL A;  2GLQ A;  2VQR A;  5K4P A;  4CXU A;  2GSU A;  1SHN A;  5DLT A;  3LXQ A;  4CYR A;  1HJK A;  1ELZ A;  1B8J A;  1E33 P;  4UPI A;  1HDH A;  4ZG6 A;  3BDG B;  5KXA A;  2GA3 A;  1K7H A;  1SHQ A;  2W5Q A;  5GOV A;  4ZG9 A;  1AJA A;  4LR8 A;  1KHN A;  2W5R A;  1Y7A A;  3IGZ B;  1ZEB A;  1EW2 A;  2GSO A;  1AJB A;  4UOR A;  3TWZ A;  3WAY A;  1Y6V A;  5EGE A;  1ELY A;  1URA A;  2W5S A;  2RH6 A;  3M8Y A;  4GTY A;  4LR9 A;  1ELX A;  5IJS A;  1ALK A;  3SZY A;  3TX0 A;  1EW8 A;  3KD8 A;  5LQQ A;  1E3C P;  3MK2 A;  4KJG A;  3UN2 A;  4MHX A;  3CMR A;  1AJC A; 
#chains in the Genus database with same CATH homology
 3SZZ A;  2XR9 A;  3WAX A;  3Q3Q A;  1EI6 A;  4ZG7 A;  3NKM A;  4ZGA A;  3M7V A;  2X98 A;  3UN5 A;  1ZEF A;  4MIV A;  4LR2 A;  3WAW A;  4KM4 A;  4LRA A;  4CXK A;  4LRF A;  3NKO A;  4LRE A;  3DPC A;  2ZKT A;  1ANI A;  5DLV A;  3NKN A;  3T02 A;  4UOP A;  5INH A;  3IDD A;  2QZU A;  4CXS A;  1KHJ A;  1EJJ A;  4GTZ A;  2XRG A;  1O99 A;  3WAV A;  5L0B A;  4UOO A;  2W5V A;  2W8D A;  3T01 A;  1N2K A;  4GTW A;  2IUC B;  1EW9 A;  4KAV A;  3MK1 A;  1AJD A;  2W8S A;  4UPH A;  3TG0 A;  2GSN A;  2ANH A;  4B56 A;  5DLW A;  1E1Z P;  1HQA A;  3BDF A;  3WBH A;  4LR7 A;  1KH5 A;  4FDI A;  1KHL A;  4FDJ A;  4N7T A;  1ALI A;  1KH4 A;  3T00 A;  1KH7 A;  3OT9 A;  4KJD A;  2IFY A;  4LRC A;  3UO0 A;  5HRT A;  3BDG A;  3A52 A;  2D1G A;  4UPK A;  4MY4 A;  5IJQ A;  4UPL A;  3MK0 A;  4YR1 A;  5TJ3 A;  1ANJ A;  1E2S P;  1O98 A;  5EGH A;  1AUK A;  2W5W A;  5C66 A;  5LRM A;  2W5X A;  4KAY A;  3B5Q A;  1ALH A;  1P49 A;  5LRN A;  3NKP A;  2W5T A;  4CYS A;  1N2L A;  4QAX A;  5AJ9 A;  1ED9 A;  1ALJ A;  1FSU A;  3NKR A;  3IGY B;  3M8Z A;  4GTX A;  3NKQ A;  2IUC A;  1EQJ A;  4NWJ A;  1KH9 A;  4LRD A;  4NWX A;  3UN3 A;  4LRB A;  1KHK A;  1URB A;  2G9Y A;  3E2D A;  3M8W A;  3UNY A;  5LIA A;  5GRR A;  3ED4 A;  3BDH A;  4LQY A;  5L0K A;  4TN0 A;  1ED8 A;  5L0E A;  3DYC A;  1ZED A;  3NVL A;  2GLQ A;  2VQR A;  5K4P A;  4CXU A;  2GSU A;  1SHN A;  5DLT A;  3LXQ A;  4CYR A;  1HJK A;  1ELZ A;  1B8J A;  1E33 P;  4UPI A;  1HDH A;  4ZG6 A;  3BDG B;  5KXA A;  2GA3 A;  1K7H A;  1SHQ A;  2W5Q A;  5GOV A;  4ZG9 A;  1AJA A;  4LR8 A;  1KHN A;  2W5R A;  1Y7A A;  3IGZ B;  1ZEB A;  1EW2 A;  2GSO A;  1AJB A;  4UOR A;  3TWZ A;  3WAY A;  1Y6V A;  5EGE A;  1ELY A;  1URA A;  2W5S A;  2RH6 A;  3M8Y A;  4GTY A;  4LR9 A;  1ELX A;  5IJS A;  1ALK A;  3SZY A;  3TX0 A;  1EW8 A;  3KD8 A;  5LQQ A;  1E3C P;  3MK2 A;  4KJG A;  3UN2 A;  4MHX A;  3CMR A;  1AJC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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