1ZEDA

Alkaline phosphatase from human placenta in complex with p-nitrophenyl-phosphonate
Total Genus 177
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
177
Knots found
sequence length
481
structure length
481
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus 177
structure length 481
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2005-04-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1zedA00
1N2KA 5EGHA 2W5XA 1HQAA 3UO0A 4FDIA 4YR1A 1K7HA 4FDJA 4LRFA 3MK0A 3NKPA 5DLWA 4KJGA 3SZZA 4ZG7A 1AJCA 4UPIA 4CXSA 3WAYA 2W5SA 5DLTA 4KM4A 3WAWA 4LR7A 4N7TA 4QAXA 4LREA 4LR9A 3LXQA 1N2LA 5EGEA 3MK2A 4LR2A 4CXKA 1SHNA 2IUCB 5L0KA 4KJDA 3M8WA 2QZUA 1ED8A 1Y6VA 2W8SA 3NKMA 4LRAA 5GOVA 3UNYA 4B56A 1ALHA 1AJAA 1E1ZP 2W5QA 2ANHA 1EW2A 3MK1A 3UN3A 1EJJA 3NKOA 4MY4A 2GSNA 3NKNA 5DLVA 1EQJA 1ANIA 5K4PA 4GTWA 3BDHA 4ZGAA 5L0BA 3ED4A 3OT9A 2GSUA 2W5VA 5LRMA 5KXAA 1URAA 2IFYA 3IDDA 1B8JA 3NKRA 3BDGB 1FSUA 1KH7A 2ZKTA 5TJ3A 5IJSA 4LR8A 1KHNA 5LQQA 3IGYB 1ALJA 1ELZA 3TX0A 1O98A 5LRNA 1P49A 3NVLA 3Q3QA 4UPLA 2XR9A 4GTXA 3SZYA 4CYSA 3WAVA 4LRCA 4UPKA 3E2DA 3M8ZA 4LRDA 4ZG9A 3M7VA 2RH6A 3T00A 4ZG6A 1KHJA 4LRBA 4MHXA 1HDHA 5IJQA 3DYCA 2W5TA 1Y7AA 4UPHA 3DPCA 4GTZA 4KAYA 2GA3A 1SHQA 1KHLA 3TWZA 4TN0A 3TG0A 2VQRA 1HJKA 3T01A 1ELXA 3M8YA 3T02A 1E33P 3UN2A 3NKQA 1ELYA 4UORA 5LIAA 3B5QA 1ED9A 5INHA 1ZEFA 1AJDA 1KH5A 3BDFA 2W5RA 3CMRA 3WAXA 4GTYA 1AUKA 5L0EA 2D1GA 3UN5A 2GLQA 4NWXA 1EI6A 1EW9A 4UOOA 5C66A 2GSOA 3KD8A 3A52A 1O99A 1URBA 4UOPA 4KAVA 1EW8A 2W8DA 4LQYA 2W5WA 1KH9A 1AJBA 2IUCA 4CYRA 3BDGA 5AJ9A 1ZEDA 2X98A 1ZEBA 1ALKA 5HRTA 1ALIA 1KH4A 4NWJA 3WBHA 2G9YA 4CXUA 4MIVA 1E2SP 1E3CP 2XRGA 5GRRA 1KHKA 3IGZB 1ANJA
chains in the Genus database with same CATH superfamily
1N2KA 5EGHA 2W5XA 1HQAA 3UO0A 4FDIA 4YR1A 1K7HA 4FDJA 4LRFA 3MK0A 3NKPA 5DLWA 4KJGA 3SZZA 4ZG7A 1AJCA 4UPIA 4CXSA 3WAYA 2W5SA 5DLTA 4KM4A 3WAWA 4LR7A 4N7TA 4QAXA 4LREA 4LR9A 3LXQA 1N2LA 5EGEA 3MK2A 4LR2A 4CXKA 1SHNA 2IUCB 5L0KA 4KJDA 3M8WA 2QZUA 1ED8A 1Y6VA 2W8SA 3NKMA 4LRAA 5GOVA 3UNYA 4B56A 1ALHA 1AJAA 1E1ZP 2W5QA 2ANHA 1EW2A 3MK1A 3UN3A 1EJJA 3NKOA 4MY4A 2GSNA 3NKNA 5DLVA 1EQJA 1ANIA 5K4PA 4GTWA 3BDHA 4ZGAA 5L0BA 3ED4A 3OT9A 2GSUA 2W5VA 5LRMA 5KXAA 1URAA 2IFYA 3IDDA 1B8JA 3NKRA 3BDGB 1FSUA 1KH7A 2ZKTA 5TJ3A 5IJSA 4LR8A 1KHNA 5LQQA 3IGYB 1ALJA 1ELZA 3TX0A 1O98A 5LRNA 1P49A 3NVLA 3Q3QA 4UPLA 2XR9A 4GTXA 3SZYA 4CYSA 3WAVA 4LRCA 4UPKA 3E2DA 3M8ZA 4LRDA 4ZG9A 3M7VA 2RH6A 3T00A 4ZG6A 1KHJA 4LRBA 4MHXA 1HDHA 5IJQA 3DYCA 2W5TA 1Y7AA 4UPHA 3DPCA 4GTZA 4KAYA 2GA3A 1SHQA 1KHLA 3TWZA 4TN0A 3TG0A 2VQRA 1HJKA 3T01A 1ELXA 3M8YA 3T02A 1E33P 3UN2A 3NKQA 1ELYA 4UORA 5LIAA 3B5QA 1ED9A 5INHA 1ZEFA 1AJDA 1KH5A 3BDFA 2W5RA 3CMRA 3WAXA 4GTYA 1AUKA 5L0EA 2D1GA 3UN5A 2GLQA 4NWXA 1EI6A 1EW9A 4UOOA 5C66A 2GSOA 3KD8A 3A52A 1O99A 1URBA 4UOPA 4KAVA 1EW8A 2W8DA 4LQYA 2W5WA 1KH9A 1AJBA 2IUCA 4CYRA 3BDGA 5AJ9A 1ZEDA 2X98A 1ZEBA 1ALKA 5HRTA 1ALIA 1KH4A 4NWJA 3WBHA 2G9YA 4CXUA 4MIVA 1E2SP 1E3CP 2XRGA 5GRRA 1KHKA 3IGZB 1ANJA
chains in the Genus database with same CATH topology
1N2KA 5EGHA 2W5XA 1HQAA 3UO0A 4FDIA 4YR1A 1K7HA 4FDJA 4LRFA 3MK0A 3NKPA 5DLWA 4KJGA 3SZZA 4ZG7A 1AJCA 4UPIA 4CXSA 3WAYA 2W5SA 5DLTA 4KM4A 3WAWA 4LR7A 4N7TA 4QAXA 4LREA 4LR9A 3LXQA 1N2LA 5EGEA 3MK2A 4LR2A 4CXKA 1SHNA 2IUCB 5L0KA 4KJDA 3M8WA 2QZUA 1ED8A 1Y6VA 2W8SA 3NKMA 4LRAA 5GOVA 3UNYA 4B56A 1ALHA 1AJAA 1E1ZP 2W5QA 2ANHA 1EW2A 3MK1A 3UN3A 1EJJA 3NKOA 4MY4A 2GSNA 3NKNA 5DLVA 1EQJA 1ANIA 5K4PA 4GTWA 3BDHA 4ZGAA 5L0BA 3ED4A 3OT9A 2GSUA 2W5VA 5LRMA 5KXAA 1URAA 2IFYA 3IDDA 1B8JA 3NKRA 3BDGB 1FSUA 1KH7A 2ZKTA 5TJ3A 5IJSA 4LR8A 1KHNA 5LQQA 3IGYB 1ALJA 1ELZA 3TX0A 1O98A 5LRNA 1P49A 3NVLA 3Q3QA 4UPLA 2XR9A 4GTXA 3SZYA 4CYSA 3WAVA 4LRCA 4UPKA 3E2DA 3M8ZA 4LRDA 4ZG9A 3M7VA 2RH6A 3T00A 4ZG6A 1KHJA 4LRBA 4MHXA 1HDHA 5IJQA 3DYCA 2W5TA 1Y7AA 4UPHA 3DPCA 4GTZA 4KAYA 2GA3A 1SHQA 1KHLA 3TWZA 4TN0A 3TG0A 2VQRA 1HJKA 3T01A 1ELXA 3M8YA 3T02A 1E33P 3UN2A 3NKQA 1ELYA 4UORA 5LIAA 3B5QA 1ED9A 5INHA 1ZEFA 1AJDA 1KH5A 3BDFA 2W5RA 3CMRA 3WAXA 4GTYA 1AUKA 5L0EA 2D1GA 3UN5A 2GLQA 4NWXA 1EI6A 1EW9A 4UOOA 5C66A 2GSOA 3KD8A 3A52A 1O99A 1URBA 4UOPA 4KAVA 1EW8A 2W8DA 4LQYA 2W5WA 1KH9A 1AJBA 2IUCA 4CYRA 3BDGA 5AJ9A 1ZEDA 2X98A 1ZEBA 1ALKA 5HRTA 1ALIA 1KH4A 4NWJA 3WBHA 2G9YA 4CXUA 4MIVA 1E2SP 1E3CP 2XRGA 5GRRA 1KHKA 3IGZB 1ANJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1N2K A;  5EGH A;  2W5X A;  1HQA A;  3UO0 A;  4FDI A;  4YR1 A;  1K7H A;  4FDJ A;  4LRF A;  3MK0 A;  3NKP A;  5DLW A;  4KJG A;  3SZZ A;  4ZG7 A;  1AJC A;  4UPI A;  4CXS A;  3WAY A;  2W5S A;  5DLT A;  4KM4 A;  3WAW A;  4LR7 A;  4N7T A;  4QAX A;  4LRE A;  4LR9 A;  3LXQ A;  1N2L A;  5EGE A;  3MK2 A;  4LR2 A;  4CXK A;  1SHN A;  2IUC B;  5L0K A;  4KJD A;  3M8W A;  2QZU A;  1ED8 A;  1Y6V A;  2W8S A;  3NKM A;  4LRA A;  5GOV A;  3UNY A;  4B56 A;  1ALH A;  1AJA A;  1E1Z P;  2W5Q A;  2ANH A;  1EW2 A;  3MK1 A;  3UN3 A;  1EJJ A;  3NKO A;  4MY4 A;  2GSN A;  3NKN A;  5DLV A;  1EQJ A;  1ANI A;  5K4P A;  4GTW A;  3BDH A;  4ZGA A;  5L0B A;  3ED4 A;  3OT9 A;  2GSU A;  2W5V A;  5LRM A;  5KXA A;  1URA A;  2IFY A;  3IDD A;  1B8J A;  3NKR A;  3BDG B;  1FSU A;  1KH7 A;  2ZKT A;  5TJ3 A;  5IJS A;  4LR8 A;  1KHN A;  5LQQ A;  3IGY B;  1ALJ A;  1ELZ A;  3TX0 A;  1O98 A;  5LRN A;  1P49 A;  3NVL A;  3Q3Q A;  4UPL A;  2XR9 A;  4GTX A;  3SZY A;  4CYS A;  3WAV A;  4LRC A;  4UPK A;  3E2D A;  3M8Z A;  4LRD A;  4ZG9 A;  3M7V A;  2RH6 A;  3T00 A;  4ZG6 A;  1KHJ A;  4LRB A;  4MHX A;  1HDH A;  5IJQ A;  3DYC A;  2W5T A;  1Y7A A;  4UPH A;  3DPC A;  4GTZ A;  4KAY A;  2GA3 A;  1SHQ A;  1KHL A;  3TWZ A;  4TN0 A;  3TG0 A;  2VQR A;  1HJK A;  3T01 A;  1ELX A;  3M8Y A;  3T02 A;  1E33 P;  3UN2 A;  3NKQ A;  1ELY A;  4UOR A;  5LIA A;  3B5Q A;  1ED9 A;  5INH A;  1ZEF A;  1AJD A;  1KH5 A;  3BDF A;  2W5R A;  3CMR A;  3WAX A;  4GTY A;  1AUK A;  5L0E A;  2D1G A;  3UN5 A;  2GLQ A;  4NWX A;  1EI6 A;  1EW9 A;  4UOO A;  5C66 A;  2GSO A;  3KD8 A;  3A52 A;  1O99 A;  1URB A;  4UOP A;  4KAV A;  1EW8 A;  2W8D A;  4LQY A;  2W5W A;  1KH9 A;  1AJB A;  2IUC A;  4CYR A;  3BDG A;  5AJ9 A;  1ZED A;  2X98 A;  1ZEB A;  1ALK A;  5HRT A;  1ALI A;  1KH4 A;  4NWJ A;  3WBH A;  2G9Y A;  4CXU A;  4MIV A;  1E2S P;  1E3C P;  2XRG A;  5GRR A;  1KHK A;  3IGZ B;  1ANJ A; 
#chains in the Genus database with same CATH topology
 1N2K A;  5EGH A;  2W5X A;  1HQA A;  3UO0 A;  4FDI A;  4YR1 A;  1K7H A;  4FDJ A;  4LRF A;  3MK0 A;  3NKP A;  5DLW A;  4KJG A;  3SZZ A;  4ZG7 A;  1AJC A;  4UPI A;  4CXS A;  3WAY A;  2W5S A;  5DLT A;  4KM4 A;  3WAW A;  4LR7 A;  4N7T A;  4QAX A;  4LRE A;  4LR9 A;  3LXQ A;  1N2L A;  5EGE A;  3MK2 A;  4LR2 A;  4CXK A;  1SHN A;  2IUC B;  5L0K A;  4KJD A;  3M8W A;  2QZU A;  1ED8 A;  1Y6V A;  2W8S A;  3NKM A;  4LRA A;  5GOV A;  3UNY A;  4B56 A;  1ALH A;  1AJA A;  1E1Z P;  2W5Q A;  2ANH A;  1EW2 A;  3MK1 A;  3UN3 A;  1EJJ A;  3NKO A;  4MY4 A;  2GSN A;  3NKN A;  5DLV A;  1EQJ A;  1ANI A;  5K4P A;  4GTW A;  3BDH A;  4ZGA A;  5L0B A;  3ED4 A;  3OT9 A;  2GSU A;  2W5V A;  5LRM A;  5KXA A;  1URA A;  2IFY A;  3IDD A;  1B8J A;  3NKR A;  3BDG B;  1FSU A;  1KH7 A;  2ZKT A;  5TJ3 A;  5IJS A;  4LR8 A;  1KHN A;  5LQQ A;  3IGY B;  1ALJ A;  1ELZ A;  3TX0 A;  1O98 A;  5LRN A;  1P49 A;  3NVL A;  3Q3Q A;  4UPL A;  2XR9 A;  4GTX A;  3SZY A;  4CYS A;  3WAV A;  4LRC A;  4UPK A;  3E2D A;  3M8Z A;  4LRD A;  4ZG9 A;  3M7V A;  2RH6 A;  3T00 A;  4ZG6 A;  1KHJ A;  4LRB A;  4MHX A;  1HDH A;  5IJQ A;  3DYC A;  2W5T A;  1Y7A A;  4UPH A;  3DPC A;  4GTZ A;  4KAY A;  2GA3 A;  1SHQ A;  1KHL A;  3TWZ A;  4TN0 A;  3TG0 A;  2VQR A;  1HJK A;  3T01 A;  1ELX A;  3M8Y A;  3T02 A;  1E33 P;  3UN2 A;  3NKQ A;  1ELY A;  4UOR A;  5LIA A;  3B5Q A;  1ED9 A;  5INH A;  1ZEF A;  1AJD A;  1KH5 A;  3BDF A;  2W5R A;  3CMR A;  3WAX A;  4GTY A;  1AUK A;  5L0E A;  2D1G A;  3UN5 A;  2GLQ A;  4NWX A;  1EI6 A;  1EW9 A;  4UOO A;  5C66 A;  2GSO A;  3KD8 A;  3A52 A;  1O99 A;  1URB A;  4UOP A;  4KAV A;  1EW8 A;  2W8D A;  4LQY A;  2W5W A;  1KH9 A;  1AJB A;  2IUC A;  4CYR A;  3BDG A;  5AJ9 A;  1ZED A;  2X98 A;  1ZEB A;  1ALK A;  5HRT A;  1ALI A;  1KH4 A;  4NWJ A;  3WBH A;  2G9Y A;  4CXU A;  4MIV A;  1E2S P;  1E3C P;  2XRG A;  5GRR A;  1KHK A;  3IGZ B;  1ANJ A; 
#chains in the Genus database with same CATH homology
 1N2K A;  5EGH A;  2W5X A;  1HQA A;  3UO0 A;  4FDI A;  4YR1 A;  1K7H A;  4FDJ A;  4LRF A;  3MK0 A;  3NKP A;  5DLW A;  4KJG A;  3SZZ A;  4ZG7 A;  1AJC A;  4UPI A;  4CXS A;  3WAY A;  2W5S A;  5DLT A;  4KM4 A;  3WAW A;  4LR7 A;  4N7T A;  4QAX A;  4LRE A;  4LR9 A;  3LXQ A;  1N2L A;  5EGE A;  3MK2 A;  4LR2 A;  4CXK A;  1SHN A;  2IUC B;  5L0K A;  4KJD A;  3M8W A;  2QZU A;  1ED8 A;  1Y6V A;  2W8S A;  3NKM A;  4LRA A;  5GOV A;  3UNY A;  4B56 A;  1ALH A;  1AJA A;  1E1Z P;  2W5Q A;  2ANH A;  1EW2 A;  3MK1 A;  3UN3 A;  1EJJ A;  3NKO A;  4MY4 A;  2GSN A;  3NKN A;  5DLV A;  1EQJ A;  1ANI A;  5K4P A;  4GTW A;  3BDH A;  4ZGA A;  5L0B A;  3ED4 A;  3OT9 A;  2GSU A;  2W5V A;  5LRM A;  5KXA A;  1URA A;  2IFY A;  3IDD A;  1B8J A;  3NKR A;  3BDG B;  1FSU A;  1KH7 A;  2ZKT A;  5TJ3 A;  5IJS A;  4LR8 A;  1KHN A;  5LQQ A;  3IGY B;  1ALJ A;  1ELZ A;  3TX0 A;  1O98 A;  5LRN A;  1P49 A;  3NVL A;  3Q3Q A;  4UPL A;  2XR9 A;  4GTX A;  3SZY A;  4CYS A;  3WAV A;  4LRC A;  4UPK A;  3E2D A;  3M8Z A;  4LRD A;  4ZG9 A;  3M7V A;  2RH6 A;  3T00 A;  4ZG6 A;  1KHJ A;  4LRB A;  4MHX A;  1HDH A;  5IJQ A;  3DYC A;  2W5T A;  1Y7A A;  4UPH A;  3DPC A;  4GTZ A;  4KAY A;  2GA3 A;  1SHQ A;  1KHL A;  3TWZ A;  4TN0 A;  3TG0 A;  2VQR A;  1HJK A;  3T01 A;  1ELX A;  3M8Y A;  3T02 A;  1E33 P;  3UN2 A;  3NKQ A;  1ELY A;  4UOR A;  5LIA A;  3B5Q A;  1ED9 A;  5INH A;  1ZEF A;  1AJD A;  1KH5 A;  3BDF A;  2W5R A;  3CMR A;  3WAX A;  4GTY A;  1AUK A;  5L0E A;  2D1G A;  3UN5 A;  2GLQ A;  4NWX A;  1EI6 A;  1EW9 A;  4UOO A;  5C66 A;  2GSO A;  3KD8 A;  3A52 A;  1O99 A;  1URB A;  4UOP A;  4KAV A;  1EW8 A;  2W8D A;  4LQY A;  2W5W A;  1KH9 A;  1AJB A;  2IUC A;  4CYR A;  3BDG A;  5AJ9 A;  1ZED A;  2X98 A;  1ZEB A;  1ALK A;  5HRT A;  1ALI A;  1KH4 A;  4NWJ A;  3WBH A;  2G9Y A;  4CXU A;  4MIV A;  1E2S P;  1E3C P;  2XRG A;  5GRR A;  1KHK A;  3IGZ B;  1ANJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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