1ZEDA

Alkaline phosphatase from human placenta in complex with p-nitrophenyl-phosphonate
Total Genus 177
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
177
Knots found
sequence length
481
structure length
481
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus 177
structure length 481
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2005-04-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1zedA00
4CXUA 1ZEFA 2IUCA 3NKNA 5AJ9A 5INHA 3SZZA 4GTXA 3T01A 2W8DA 2XRGA 1KHJA 5KXAA 3NKMA 3MK0A 5L0KA 1KH5A 3T00A 1O99A 1URAA 2X98A 3IGYB 1AJCA 4LRCA 1EQJA 4N7TA 2GSOA 1N2KA 4KAVA 3WAVA 4UPIA 3UN2A 2W8SA 4UOOA 1ELYA 3MK2A 2W5VA 4UPLA 4KJGA 1EJJA 3TX0A 2W5WA 3DYCA 1KHKA 3BDHA 1O98A 5K4PA 1E3CP 3NKRA 1N2LA 3M8ZA 1HDHA 5IJQA 5EGEA 4QAXA 3E2DA 4LR7A 1KH4A 3WAWA 4CYRA 4NWJA 5TJ3A 4UOPA 3UNYA 1SHNA 1ALJA 3WAYA 5IJSA 2IFYA 4ZG6A 4CXSA 3OT9A 1SHQA 4GTZA 4LRFA 5L0BA 4LRBA 5EGHA 5LQQA 1AJDA 1ED9A 4LREA 3M7VA 4GTWA 4CYSA 3M8WA 1EW2A 1Y6VA 2W5SA 3NKOA 5DLWA 3NKQA 5L0EA 2RH6A 3A52A 3BDGB 3WBHA 4LR2A 2GA3A 4LR8A 4UORA 4LR9A 4MIVA 1AJBA 2GSUA 5GRRA 1K7HA 2QZUA 5LRMA 3IGZB 1P49A 5LIAA 3UO0A 4KJDA 4UPHA 4YR1A 3NVLA 2IUCB 3IDDA 4FDIA 5C66A 3KD8A 5DLVA 1AJAA 3NKPA 2XR9A 3DPCA 4GTYA 4FDJA 5GOVA 2ANHA 1EI6A 4KAYA 2VQRA 2W5QA 1HJKA 2D1GA 3WAXA 3TG0A 1EW8A 1ALHA 4ZGAA 3Q3QA 3UN3A 1ELZA 1KHNA 1E1ZP 3T02A 3CMRA 1EW9A 1E33P 4LRDA 5LRNA 2ZKTA 3SZYA 1ELXA 4CXKA 1ALIA 3LXQA 2G9YA 4B56A 3BDFA 4NWXA 3UN5A 1HQAA 2W5TA 4TN0A 1KH9A 5HRTA 2W5XA 2GSNA 3ED4A 1Y7AA 1B8JA 4UPKA 1ED8A 3M8YA 2GLQA 1KHLA 3B5QA 3MK1A 5DLTA 4KM4A 1ZEDA 4MHXA 4ZG7A 4ZG9A 1ALKA 3BDGA 4LQYA 1KH7A 1ANIA 4MY4A 4LRAA 2W5RA 1URBA 1ZEBA 3TWZA 1ANJA 1E2SP 1FSUA 1AUKA
chains in the Genus database with same CATH superfamily
4CXUA 1ZEFA 2IUCA 3NKNA 5AJ9A 5INHA 3SZZA 4GTXA 3T01A 2W8DA 2XRGA 1KHJA 5KXAA 3NKMA 3MK0A 5L0KA 1KH5A 3T00A 1O99A 1URAA 2X98A 3IGYB 1AJCA 4LRCA 1EQJA 4N7TA 2GSOA 1N2KA 4KAVA 3WAVA 4UPIA 3UN2A 2W8SA 4UOOA 1ELYA 3MK2A 2W5VA 4UPLA 4KJGA 1EJJA 3TX0A 2W5WA 3DYCA 1KHKA 3BDHA 1O98A 5K4PA 1E3CP 3NKRA 1N2LA 3M8ZA 1HDHA 5IJQA 5EGEA 4QAXA 3E2DA 4LR7A 1KH4A 3WAWA 4CYRA 4NWJA 5TJ3A 4UOPA 3UNYA 1SHNA 1ALJA 3WAYA 5IJSA 2IFYA 4ZG6A 4CXSA 3OT9A 1SHQA 4GTZA 4LRFA 5L0BA 4LRBA 5EGHA 5LQQA 1AJDA 1ED9A 4LREA 3M7VA 4GTWA 4CYSA 3M8WA 1EW2A 1Y6VA 2W5SA 3NKOA 5DLWA 3NKQA 5L0EA 2RH6A 3A52A 3BDGB 3WBHA 4LR2A 2GA3A 4LR8A 4UORA 4LR9A 4MIVA 1AJBA 2GSUA 5GRRA 1K7HA 2QZUA 5LRMA 3IGZB 1P49A 5LIAA 3UO0A 4KJDA 4UPHA 4YR1A 3NVLA 2IUCB 3IDDA 4FDIA 5C66A 3KD8A 5DLVA 1AJAA 3NKPA 2XR9A 3DPCA 4GTYA 4FDJA 5GOVA 2ANHA 1EI6A 4KAYA 2VQRA 2W5QA 1HJKA 2D1GA 3WAXA 3TG0A 1EW8A 1ALHA 4ZGAA 3Q3QA 3UN3A 1ELZA 1KHNA 1E1ZP 3T02A 3CMRA 1EW9A 1E33P 4LRDA 5LRNA 2ZKTA 3SZYA 1ELXA 4CXKA 1ALIA 3LXQA 2G9YA 4B56A 3BDFA 4NWXA 3UN5A 1HQAA 2W5TA 4TN0A 1KH9A 5HRTA 2W5XA 2GSNA 3ED4A 1Y7AA 1B8JA 4UPKA 1ED8A 3M8YA 2GLQA 1KHLA 3B5QA 3MK1A 5DLTA 4KM4A 1ZEDA 4MHXA 4ZG7A 4ZG9A 1ALKA 3BDGA 4LQYA 1KH7A 1ANIA 4MY4A 4LRAA 2W5RA 1URBA 1ZEBA 3TWZA 1ANJA 1E2SP 1FSUA 1AUKA
chains in the Genus database with same CATH topology
4CXUA 1ZEFA 2IUCA 3NKNA 5AJ9A 5INHA 3SZZA 4GTXA 3T01A 2W8DA 2XRGA 1KHJA 5KXAA 3NKMA 3MK0A 5L0KA 1KH5A 3T00A 1O99A 1URAA 2X98A 3IGYB 1AJCA 4LRCA 1EQJA 4N7TA 2GSOA 1N2KA 4KAVA 3WAVA 4UPIA 3UN2A 2W8SA 4UOOA 1ELYA 3MK2A 2W5VA 4UPLA 4KJGA 1EJJA 3TX0A 2W5WA 3DYCA 1KHKA 3BDHA 1O98A 5K4PA 1E3CP 3NKRA 1N2LA 3M8ZA 1HDHA 5IJQA 5EGEA 4QAXA 3E2DA 4LR7A 1KH4A 3WAWA 4CYRA 4NWJA 5TJ3A 4UOPA 3UNYA 1SHNA 1ALJA 3WAYA 5IJSA 2IFYA 4ZG6A 4CXSA 3OT9A 1SHQA 4GTZA 4LRFA 5L0BA 4LRBA 5EGHA 5LQQA 1AJDA 1ED9A 4LREA 3M7VA 4GTWA 4CYSA 3M8WA 1EW2A 1Y6VA 2W5SA 3NKOA 5DLWA 3NKQA 5L0EA 2RH6A 3A52A 3BDGB 3WBHA 4LR2A 2GA3A 4LR8A 4UORA 4LR9A 4MIVA 1AJBA 2GSUA 5GRRA 1K7HA 2QZUA 5LRMA 3IGZB 1P49A 5LIAA 3UO0A 4KJDA 4UPHA 4YR1A 3NVLA 2IUCB 3IDDA 4FDIA 5C66A 3KD8A 5DLVA 1AJAA 3NKPA 2XR9A 3DPCA 4GTYA 4FDJA 5GOVA 2ANHA 1EI6A 4KAYA 2VQRA 2W5QA 1HJKA 2D1GA 3WAXA 3TG0A 1EW8A 1ALHA 4ZGAA 3Q3QA 3UN3A 1ELZA 1KHNA 1E1ZP 3T02A 3CMRA 1EW9A 1E33P 4LRDA 5LRNA 2ZKTA 3SZYA 1ELXA 4CXKA 1ALIA 3LXQA 2G9YA 4B56A 3BDFA 4NWXA 3UN5A 1HQAA 2W5TA 4TN0A 1KH9A 5HRTA 2W5XA 2GSNA 3ED4A 1Y7AA 1B8JA 4UPKA 1ED8A 3M8YA 2GLQA 1KHLA 3B5QA 3MK1A 5DLTA 4KM4A 1ZEDA 4MHXA 4ZG7A 4ZG9A 1ALKA 3BDGA 4LQYA 1KH7A 1ANIA 4MY4A 4LRAA 2W5RA 1URBA 1ZEBA 3TWZA 1ANJA 1E2SP 1FSUA 1AUKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4CXU A;  1ZEF A;  2IUC A;  3NKN A;  5AJ9 A;  5INH A;  3SZZ A;  4GTX A;  3T01 A;  2W8D A;  2XRG A;  1KHJ A;  5KXA A;  3NKM A;  3MK0 A;  5L0K A;  1KH5 A;  3T00 A;  1O99 A;  1URA A;  2X98 A;  3IGY B;  1AJC A;  4LRC A;  1EQJ A;  4N7T A;  2GSO A;  1N2K A;  4KAV A;  3WAV A;  4UPI A;  3UN2 A;  2W8S A;  4UOO A;  1ELY A;  3MK2 A;  2W5V A;  4UPL A;  4KJG A;  1EJJ A;  3TX0 A;  2W5W A;  3DYC A;  1KHK A;  3BDH A;  1O98 A;  5K4P A;  1E3C P;  3NKR A;  1N2L A;  3M8Z A;  1HDH A;  5IJQ A;  5EGE A;  4QAX A;  3E2D A;  4LR7 A;  1KH4 A;  3WAW A;  4CYR A;  4NWJ A;  5TJ3 A;  4UOP A;  3UNY A;  1SHN A;  1ALJ A;  3WAY A;  5IJS A;  2IFY A;  4ZG6 A;  4CXS A;  3OT9 A;  1SHQ A;  4GTZ A;  4LRF A;  5L0B A;  4LRB A;  5EGH A;  5LQQ A;  1AJD A;  1ED9 A;  4LRE A;  3M7V A;  4GTW A;  4CYS A;  3M8W A;  1EW2 A;  1Y6V A;  2W5S A;  3NKO A;  5DLW A;  3NKQ A;  5L0E A;  2RH6 A;  3A52 A;  3BDG B;  3WBH A;  4LR2 A;  2GA3 A;  4LR8 A;  4UOR A;  4LR9 A;  4MIV A;  1AJB A;  2GSU A;  5GRR A;  1K7H A;  2QZU A;  5LRM A;  3IGZ B;  1P49 A;  5LIA A;  3UO0 A;  4KJD A;  4UPH A;  4YR1 A;  3NVL A;  2IUC B;  3IDD A;  4FDI A;  5C66 A;  3KD8 A;  5DLV A;  1AJA A;  3NKP A;  2XR9 A;  3DPC A;  4GTY A;  4FDJ A;  5GOV A;  2ANH A;  1EI6 A;  4KAY A;  2VQR A;  2W5Q A;  1HJK A;  2D1G A;  3WAX A;  3TG0 A;  1EW8 A;  1ALH A;  4ZGA A;  3Q3Q A;  3UN3 A;  1ELZ A;  1KHN A;  1E1Z P;  3T02 A;  3CMR A;  1EW9 A;  1E33 P;  4LRD A;  5LRN A;  2ZKT A;  3SZY A;  1ELX A;  4CXK A;  1ALI A;  3LXQ A;  2G9Y A;  4B56 A;  3BDF A;  4NWX A;  3UN5 A;  1HQA A;  2W5T A;  4TN0 A;  1KH9 A;  5HRT A;  2W5X A;  2GSN A;  3ED4 A;  1Y7A A;  1B8J A;  4UPK A;  1ED8 A;  3M8Y A;  2GLQ A;  1KHL A;  3B5Q A;  3MK1 A;  5DLT A;  4KM4 A;  1ZED A;  4MHX A;  4ZG7 A;  4ZG9 A;  1ALK A;  3BDG A;  4LQY A;  1KH7 A;  1ANI A;  4MY4 A;  4LRA A;  2W5R A;  1URB A;  1ZEB A;  3TWZ A;  1ANJ A;  1E2S P;  1FSU A;  1AUK A; 
#chains in the Genus database with same CATH topology
 4CXU A;  1ZEF A;  2IUC A;  3NKN A;  5AJ9 A;  5INH A;  3SZZ A;  4GTX A;  3T01 A;  2W8D A;  2XRG A;  1KHJ A;  5KXA A;  3NKM A;  3MK0 A;  5L0K A;  1KH5 A;  3T00 A;  1O99 A;  1URA A;  2X98 A;  3IGY B;  1AJC A;  4LRC A;  1EQJ A;  4N7T A;  2GSO A;  1N2K A;  4KAV A;  3WAV A;  4UPI A;  3UN2 A;  2W8S A;  4UOO A;  1ELY A;  3MK2 A;  2W5V A;  4UPL A;  4KJG A;  1EJJ A;  3TX0 A;  2W5W A;  3DYC A;  1KHK A;  3BDH A;  1O98 A;  5K4P A;  1E3C P;  3NKR A;  1N2L A;  3M8Z A;  1HDH A;  5IJQ A;  5EGE A;  4QAX A;  3E2D A;  4LR7 A;  1KH4 A;  3WAW A;  4CYR A;  4NWJ A;  5TJ3 A;  4UOP A;  3UNY A;  1SHN A;  1ALJ A;  3WAY A;  5IJS A;  2IFY A;  4ZG6 A;  4CXS A;  3OT9 A;  1SHQ A;  4GTZ A;  4LRF A;  5L0B A;  4LRB A;  5EGH A;  5LQQ A;  1AJD A;  1ED9 A;  4LRE A;  3M7V A;  4GTW A;  4CYS A;  3M8W A;  1EW2 A;  1Y6V A;  2W5S A;  3NKO A;  5DLW A;  3NKQ A;  5L0E A;  2RH6 A;  3A52 A;  3BDG B;  3WBH A;  4LR2 A;  2GA3 A;  4LR8 A;  4UOR A;  4LR9 A;  4MIV A;  1AJB A;  2GSU A;  5GRR A;  1K7H A;  2QZU A;  5LRM A;  3IGZ B;  1P49 A;  5LIA A;  3UO0 A;  4KJD A;  4UPH A;  4YR1 A;  3NVL A;  2IUC B;  3IDD A;  4FDI A;  5C66 A;  3KD8 A;  5DLV A;  1AJA A;  3NKP A;  2XR9 A;  3DPC A;  4GTY A;  4FDJ A;  5GOV A;  2ANH A;  1EI6 A;  4KAY A;  2VQR A;  2W5Q A;  1HJK A;  2D1G A;  3WAX A;  3TG0 A;  1EW8 A;  1ALH A;  4ZGA A;  3Q3Q A;  3UN3 A;  1ELZ A;  1KHN A;  1E1Z P;  3T02 A;  3CMR A;  1EW9 A;  1E33 P;  4LRD A;  5LRN A;  2ZKT A;  3SZY A;  1ELX A;  4CXK A;  1ALI A;  3LXQ A;  2G9Y A;  4B56 A;  3BDF A;  4NWX A;  3UN5 A;  1HQA A;  2W5T A;  4TN0 A;  1KH9 A;  5HRT A;  2W5X A;  2GSN A;  3ED4 A;  1Y7A A;  1B8J A;  4UPK A;  1ED8 A;  3M8Y A;  2GLQ A;  1KHL A;  3B5Q A;  3MK1 A;  5DLT A;  4KM4 A;  1ZED A;  4MHX A;  4ZG7 A;  4ZG9 A;  1ALK A;  3BDG A;  4LQY A;  1KH7 A;  1ANI A;  4MY4 A;  4LRA A;  2W5R A;  1URB A;  1ZEB A;  3TWZ A;  1ANJ A;  1E2S P;  1FSU A;  1AUK A; 
#chains in the Genus database with same CATH homology
 4CXU A;  1ZEF A;  2IUC A;  3NKN A;  5AJ9 A;  5INH A;  3SZZ A;  4GTX A;  3T01 A;  2W8D A;  2XRG A;  1KHJ A;  5KXA A;  3NKM A;  3MK0 A;  5L0K A;  1KH5 A;  3T00 A;  1O99 A;  1URA A;  2X98 A;  3IGY B;  1AJC A;  4LRC A;  1EQJ A;  4N7T A;  2GSO A;  1N2K A;  4KAV A;  3WAV A;  4UPI A;  3UN2 A;  2W8S A;  4UOO A;  1ELY A;  3MK2 A;  2W5V A;  4UPL A;  4KJG A;  1EJJ A;  3TX0 A;  2W5W A;  3DYC A;  1KHK A;  3BDH A;  1O98 A;  5K4P A;  1E3C P;  3NKR A;  1N2L A;  3M8Z A;  1HDH A;  5IJQ A;  5EGE A;  4QAX A;  3E2D A;  4LR7 A;  1KH4 A;  3WAW A;  4CYR A;  4NWJ A;  5TJ3 A;  4UOP A;  3UNY A;  1SHN A;  1ALJ A;  3WAY A;  5IJS A;  2IFY A;  4ZG6 A;  4CXS A;  3OT9 A;  1SHQ A;  4GTZ A;  4LRF A;  5L0B A;  4LRB A;  5EGH A;  5LQQ A;  1AJD A;  1ED9 A;  4LRE A;  3M7V A;  4GTW A;  4CYS A;  3M8W A;  1EW2 A;  1Y6V A;  2W5S A;  3NKO A;  5DLW A;  3NKQ A;  5L0E A;  2RH6 A;  3A52 A;  3BDG B;  3WBH A;  4LR2 A;  2GA3 A;  4LR8 A;  4UOR A;  4LR9 A;  4MIV A;  1AJB A;  2GSU A;  5GRR A;  1K7H A;  2QZU A;  5LRM A;  3IGZ B;  1P49 A;  5LIA A;  3UO0 A;  4KJD A;  4UPH A;  4YR1 A;  3NVL A;  2IUC B;  3IDD A;  4FDI A;  5C66 A;  3KD8 A;  5DLV A;  1AJA A;  3NKP A;  2XR9 A;  3DPC A;  4GTY A;  4FDJ A;  5GOV A;  2ANH A;  1EI6 A;  4KAY A;  2VQR A;  2W5Q A;  1HJK A;  2D1G A;  3WAX A;  3TG0 A;  1EW8 A;  1ALH A;  4ZGA A;  3Q3Q A;  3UN3 A;  1ELZ A;  1KHN A;  1E1Z P;  3T02 A;  3CMR A;  1EW9 A;  1E33 P;  4LRD A;  5LRN A;  2ZKT A;  3SZY A;  1ELX A;  4CXK A;  1ALI A;  3LXQ A;  2G9Y A;  4B56 A;  3BDF A;  4NWX A;  3UN5 A;  1HQA A;  2W5T A;  4TN0 A;  1KH9 A;  5HRT A;  2W5X A;  2GSN A;  3ED4 A;  1Y7A A;  1B8J A;  4UPK A;  1ED8 A;  3M8Y A;  2GLQ A;  1KHL A;  3B5Q A;  3MK1 A;  5DLT A;  4KM4 A;  1ZED A;  4MHX A;  4ZG7 A;  4ZG9 A;  1ALK A;  3BDG A;  4LQY A;  1KH7 A;  1ANI A;  4MY4 A;  4LRA A;  2W5R A;  1URB A;  1ZEB A;  3TWZ A;  1ANJ A;  1E2S P;  1FSU A;  1AUK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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