1ZR5A

Crystal structure of the macro-domain of human core histone variant macroh2a1.2
Total Genus 59
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
59
sequence length
189
structure length
189
Chain Sequence
DGFTVLSTKSLFLGQKLNLIHSEISNLAGFEVEAIINPTNADIDLKDDLGNTLEKKGGKEFVEAVLELRKKNGPLEVAGAAVSAGHGLPAKFVIHCNSPVWGADKCEELLEKTVKNCLALADDKKLKSIAFPSIGSGRNGFPKQTAAQLILKAISSYFVSTMSSSIKTVYFVLFDSESIGIYVQEMAKL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Splicing regulates NAD metabolite binding to histone macroH2A.
pubmed doi rcsb
molecule tags Gene regulation
source organism Homo sapiens
molecule keywords H2AFY protein
total genus 59
structure length 189
sequence length 189
chains with identical sequence B
ec nomenclature
pdb deposition date 2005-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01661 Macro Macro domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E; domain 1 Leucine Aminopeptidase, subunit E, domain 1 1zr5A00
5HOLA 1LANA 1TXZA 5DUSA 1LAPA 5FSZA 1NJRA 4JGKA 3Q6ZA 3SIGA 4J5SA 5FSXA 1HJZA 5CB5A 3IIDA 4K3NA 2BFQA 4JCAA 2DX6A 5FSYA 5CB3A 1VHUA 3GPOA 1BPMA 4ETKA 4ABLA 3Q71A 5HIHA 4KSIA 5CMSA 4GVWA 4ZY0A 3EJFA 4IQYA 3H8EA 3T8WA 2EEEA 3H8FA 4ZX8A 4JLLA 5FSUA 3JZTA 4GUAA 3EWOA 3VFQA 5E3BA 4ZYQA 3EWQA 4ESSA 2VRIA 4J5RA 4ABKA 2FXKA 4K0CA 1LAMA 3GPQA 2LGRA 3EWRA 1SPVA 4R76A 3IJ3A 3KQXA 4ZY2A 2BFRA 2EWBA 3EKEA 4JVVA 1YD9A 4R6TA 5CBMA 2XD7A 3EJGA 3EWPA 5AILA 2FAVA 3KZWA 1BPNA 2ACFA 3JRUA 5D8NA 1LCPA 3IIFA 3KQZA 4ZY1A 4ZX9A 4J5QA 3V45A 4TU0A 3V2BA 4UMLA 3ETIA 1ZR3A 4D86A 3KR4A 2J9AA 4R7MA 4KYBA 3GQEA 4J4ZA 3GPGA 3H8GA 3PEIA 3SIHA 1ZR5A 4ZI6A 2AFCA 3GQOA 4ETJA 2X47A 3KR5A 2FG1A 3SIJA 1GYTA 1TY8A 1BLLE 3EW5A 3SIIA 5FSVA 2L8RA 4X2TA 4GVVA
chains in the Genus database with same CATH superfamily
5HOLA 1LANA 1TXZA 5DUSA 1LAPA 5FSZA 1NJRA 4JGKA 3Q6ZA 3SIGA 4J5SA 5FSXA 1HJZA 5CB5A 3IIDA 4K3NA 2BFQA 4JCAA 2DX6A 5FSYA 5CB3A 2JZDA 1VHUA 3GPOA 1BPMA 2JZEA 4ETKA 4ABLA 3Q71A 5HIHA 4KSIA 5CMSA 4GVWA 4ZY0A 3EJFA 4IQYA 2RNKA 3H8EA 3T8WA 2EEEA 3H8FA 2W2GA 4ZX8A 4JLLA 5FSUA 3JZTA 4GUAA 3EWOA 3VFQA 5E3BA 4ZYQA 3EWQA 4ESSA 2VRIA 4J5RA 4ABKA 2FXKA 4K0CA 1LAMA 3GPQA 2LGRA 3EWRA 1SPVA 4R76A 3IJ3A 3KQXA 4ZY2A 2BFRA 2EWBA 3EKEA 4JVVA 1YD9A 4R6TA 5CBMA 2XD7A 3EJGA 3EWPA 5AILA 2FAVA 3KZWA 1BPNA 2ACFA 3JRUA 2JZFA 5D8NA 1LCPA 3IIFA 3KQZA 4ZY1A 4ZX9A 4J5QA 3V45A 4TU0A 3V2BA 4UMLA 3ETIA 1ZR3A 4D86A 3KR4A 2J9AA 4R7MA 4KYBA 3GQEA 2WCTA 4J4ZA 3GPGA 3H8GA 3PEIA 3SIHA 1ZR5A 4ZI6A 2AFCA 3GQOA 4ETJA 2X47A 3KR5A 2FG1A 2KQVA 3SIJA 1GYTA 1TY8A 1BLLE 3EW5A 3SIIA 5FSVA 2L8RA 4X2TA 4GVVA
chains in the Genus database with same CATH topology
5HOLA 1LANA 1TXZA 5DUSA 1LAPA 5FSZA 1NJRA 4JGKA 3Q6ZA 3SIGA 4J5SA 5FSXA 1HJZA 5CB5A 3IIDA 4K3NA 2BFQA 4JCAA 2DX6A 5FSYA 5CB3A 1VHUA 3GPOA 1BPMA 4ETKA 4ABLA 3Q71A 5HIHA 4KSIA 5CMSA 4GVWA 4ZY0A 3EJFA 4IQYA 3H8EA 3T8WA 2EEEA 3H8FA 4ZX8A 4JLLA 5FSUA 3JZTA 4GUAA 3EWOA 3VFQA 5E3BA 4ZYQA 3EWQA 4ESSA 2VRIA 4J5RA 4ABKA 2FXKA 4K0CA 1LAMA 3GPQA 2LGRA 3EWRA 1SPVA 4R76A 3IJ3A 3KQXA 4ZY2A 2BFRA 2EWBA 3EKEA 4JVVA 1YD9A 4R6TA 5CBMA 2XD7A 3EJGA 3EWPA 5AILA 2FAVA 3KZWA 1BPNA 2ACFA 3JRUA 5D8NA 1LCPA 3IIFA 3KQZA 4ZY1A 4ZX9A 4J5QA 3V45A 4TU0A 3V2BA 4UMLA 3ETIA 1ZR3A 4D86A 3KR4A 2J9AA 4R7MA 4KYBA 3GQEA 4J4ZA 3GPGA 3H8GA 3PEIA 3SIHA 1ZR5A 4ZI6A 2AFCA 3GQOA 4ETJA 2X47A 3KR5A 2FG1A 3SIJA 1GYTA 1TY8A 1BLLE 3EW5A 3SIIA 5FSVA 2L8RA 4X2TA 4GVVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5HOL A;  1LAN A;  1TXZ A;  5DUS A;  1LAP A;  5FSZ A;  1NJR A;  4JGK A;  3Q6Z A;  3SIG A;  4J5S A;  5FSX A;  1HJZ A;  5CB5 A;  3IID A;  4K3N A;  2BFQ A;  4JCA A;  2DX6 A;  5FSY A;  5CB3 A;  1VHU A;  3GPO A;  1BPM A;  4ETK A;  4ABL A;  3Q71 A;  5HIH A;  4KSI A;  5CMS A;  4GVW A;  4ZY0 A;  3EJF A;  4IQY A;  3H8E A;  3T8W A;  2EEE A;  3H8F A;  4ZX8 A;  4JLL A;  5FSU A;  3JZT A;  4GUA A;  3EWO A;  3VFQ A;  5E3B A;  4ZYQ A;  3EWQ A;  4ESS A;  2VRI A;  4J5R A;  4ABK A;  2FXK A;  4K0C A;  1LAM A;  3GPQ A;  2LGR A;  3EWR A;  1SPV A;  4R76 A;  3IJ3 A;  3KQX A;  4ZY2 A;  2BFR A;  2EWB A;  3EKE A;  4JVV A;  1YD9 A;  4R6T A;  5CBM A;  2XD7 A;  3EJG A;  3EWP A;  5AIL A;  2FAV A;  3KZW A;  1BPN A;  2ACF A;  3JRU A;  5D8N A;  1LCP A;  3IIF A;  3KQZ A;  4ZY1 A;  4ZX9 A;  4J5Q A;  3V45 A;  4TU0 A;  3V2B A;  4UML A;  3ETI A;  1ZR3 A;  4D86 A;  3KR4 A;  2J9A A;  4R7M A;  4KYB A;  3GQE A;  4J4Z A;  3GPG A;  3H8G A;  3PEI A;  3SIH A;  1ZR5 A;  4ZI6 A;  2AFC A;  3GQO A;  4ETJ A;  2X47 A;  3KR5 A;  2FG1 A;  3SIJ A;  1GYT A;  1TY8 A;  1BLL E;  3EW5 A;  3SII A;  5FSV A;  2L8R A;  4X2T A;  4GVV A; 
#chains in the Genus database with same CATH topology
 5HOL A;  1LAN A;  1TXZ A;  5DUS A;  1LAP A;  5FSZ A;  1NJR A;  4JGK A;  3Q6Z A;  3SIG A;  4J5S A;  5FSX A;  1HJZ A;  5CB5 A;  3IID A;  4K3N A;  2BFQ A;  4JCA A;  2DX6 A;  5FSY A;  5CB3 A;  2JZD A;  1VHU A;  3GPO A;  1BPM A;  2JZE A;  4ETK A;  4ABL A;  3Q71 A;  5HIH A;  4KSI A;  5CMS A;  4GVW A;  4ZY0 A;  3EJF A;  4IQY A;  2RNK A;  3H8E A;  3T8W A;  2EEE A;  3H8F A;  2W2G A;  4ZX8 A;  4JLL A;  5FSU A;  3JZT A;  4GUA A;  3EWO A;  3VFQ A;  5E3B A;  4ZYQ A;  3EWQ A;  4ESS A;  2VRI A;  4J5R A;  4ABK A;  2FXK A;  4K0C A;  1LAM A;  3GPQ A;  2LGR A;  3EWR A;  1SPV A;  4R76 A;  3IJ3 A;  3KQX A;  4ZY2 A;  2BFR A;  2EWB A;  3EKE A;  4JVV A;  1YD9 A;  4R6T A;  5CBM A;  2XD7 A;  3EJG A;  3EWP A;  5AIL A;  2FAV A;  3KZW A;  1BPN A;  2ACF A;  3JRU A;  2JZF A;  5D8N A;  1LCP A;  3IIF A;  3KQZ A;  4ZY1 A;  4ZX9 A;  4J5Q A;  3V45 A;  4TU0 A;  3V2B A;  4UML A;  3ETI A;  1ZR3 A;  4D86 A;  3KR4 A;  2J9A A;  4R7M A;  4KYB A;  3GQE A;  2WCT A;  4J4Z A;  3GPG A;  3H8G A;  3PEI A;  3SIH A;  1ZR5 A;  4ZI6 A;  2AFC A;  3GQO A;  4ETJ A;  2X47 A;  3KR5 A;  2FG1 A;  2KQV A;  3SIJ A;  1GYT A;  1TY8 A;  1BLL E;  3EW5 A;  3SII A;  5FSV A;  2L8R A;  4X2T A;  4GVV A; 
#chains in the Genus database with same CATH homology
 5HOL A;  1LAN A;  1TXZ A;  5DUS A;  1LAP A;  5FSZ A;  1NJR A;  4JGK A;  3Q6Z A;  3SIG A;  4J5S A;  5FSX A;  1HJZ A;  5CB5 A;  3IID A;  4K3N A;  2BFQ A;  4JCA A;  2DX6 A;  5FSY A;  5CB3 A;  1VHU A;  3GPO A;  1BPM A;  4ETK A;  4ABL A;  3Q71 A;  5HIH A;  4KSI A;  5CMS A;  4GVW A;  4ZY0 A;  3EJF A;  4IQY A;  3H8E A;  3T8W A;  2EEE A;  3H8F A;  4ZX8 A;  4JLL A;  5FSU A;  3JZT A;  4GUA A;  3EWO A;  3VFQ A;  5E3B A;  4ZYQ A;  3EWQ A;  4ESS A;  2VRI A;  4J5R A;  4ABK A;  2FXK A;  4K0C A;  1LAM A;  3GPQ A;  2LGR A;  3EWR A;  1SPV A;  4R76 A;  3IJ3 A;  3KQX A;  4ZY2 A;  2BFR A;  2EWB A;  3EKE A;  4JVV A;  1YD9 A;  4R6T A;  5CBM A;  2XD7 A;  3EJG A;  3EWP A;  5AIL A;  2FAV A;  3KZW A;  1BPN A;  2ACF A;  3JRU A;  5D8N A;  1LCP A;  3IIF A;  3KQZ A;  4ZY1 A;  4ZX9 A;  4J5Q A;  3V45 A;  4TU0 A;  3V2B A;  4UML A;  3ETI A;  1ZR3 A;  4D86 A;  3KR4 A;  2J9A A;  4R7M A;  4KYB A;  3GQE A;  4J4Z A;  3GPG A;  3H8G A;  3PEI A;  3SIH A;  1ZR5 A;  4ZI6 A;  2AFC A;  3GQO A;  4ETJ A;  2X47 A;  3KR5 A;  2FG1 A;  3SIJ A;  1GYT A;  1TY8 A;  1BLL E;  3EW5 A;  3SII A;  5FSV A;  2L8R A;  4X2T A;  4GVV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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