1AJAA

Three-dimensional structure of the d153g mutant of e. coli alkaline phosphatase: a mutant with weaker magnesium binding and increased catalytic activity
Total Genus 158
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
158
Knots found
sequence length
449
structure length
435
Chain Sequence
b'TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Crystallographic analysis of reversible metal binding observed in a mutant (Asp153-->Gly) of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Non specific mono-esterase
total genus 158
structure length 435
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-08-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ajaA00
4N7TA 4MHXA 1O98A 2GSOA 5LRMA 1EW2A 1ED8A 2GSUA 4LRDA 1ALKA 3T02A 3LXQA 4UOOA 5KXAA 4LQYA 4NWXA 1KH7A 4LR2A 1SHNA 1ELYA 3E2DA 2W5XA 1B8JA 2VQRA 5LIAA 2D1GA 3T01A 3UN5A 1KHJA 2GA3A 3WAYA 1N2KA 3MK0A 4KJGA 4CXKA 2G9YA 2ANHA 4UPHA 4GTYA 3Q3QA 4KAYA 3TG0A 2IUCA 1E1ZP 2IFYA 4KAVA 1KH9A 4CXUA 1Y7AA 3DYCA 3M8WA 1AJAA 3IGYB 3BDGB 4ZGAA 4LRAA 3BDGA 1URBA 2W8DA 5DLTA 4YR1A 1HQAA 1O99A 4FDIA 1AJBA 1EQJA 1KHLA 4MY4A 2W5QA 2W5WA 1ELZA 2W5SA 3M8ZA 4LREA 5INHA 3TX0A 4ZG6A 1ALIA 1ALJA 1ALHA 2XR9A 5GOVA 3UN3A 4KM4A 1P49A 3WAXA 2X98A 2IUCB 1KH5A 4CYRA 1AJCA 5EGEA 5L0BA 3NKRA 3ED4A 3B5QA 2ZKTA 3TWZA 2QZUA 4CXSA 1ZEFA 4LR9A 1ZEDA 1ZEBA 3A52A 3NKNA 3KD8A 3NKQA 4GTZA 1E3CP 4UPIA 4CYSA 2GSNA 3SZYA 3NKOA 1URAA 5EGHA 5LQQA 1AUKA 3DPCA 3NKMA 4QAXA 4ZG9A 3UO0A 3SZZA 5K4PA 1EW9A 1KH4A 4GTXA 3IDDA 1ELXA 4LR8A 3CMRA 5L0EA 4GTWA 4TN0A 1E33P 1EW8A 4UORA 1HDHA 2XRGA 4LRFA 5TJ3A 4UPKA 5IJSA 4LRCA 3WAWA 1FSUA 3M8YA 3MK2A 5DLVA 3WAVA 1K7HA 4UPLA 1Y6VA 4B56A 1KHNA 4FDJA 1SHQA 1KHKA 2GLQA 3MK1A 4MIVA 3NVLA 3NKPA 4LRBA 3OT9A 4UOPA 3M7VA 1E2SP 2W5RA 5L0KA 2RH6A 5GRRA 2W5VA 5LRNA 4KJDA 4NWJA 3T00A 5HRTA 1N2LA 1HJKA 5DLWA 1EJJA 3UN2A 5C66A 1ANIA 3IGZB 1EI6A 3UNYA 5AJ9A 4LR7A 1ED9A 3WBHA 1ANJA 2W8SA 3BDHA 2W5TA 4ZG7A 3BDFA 1AJDA 5IJQA
chains in the Genus database with same CATH superfamily
4N7TA 4MHXA 1O98A 2GSOA 5LRMA 1EW2A 1ED8A 2GSUA 4LRDA 1ALKA 3T02A 3LXQA 4UOOA 5KXAA 4LQYA 4NWXA 1KH7A 4LR2A 1SHNA 1ELYA 3E2DA 2W5XA 1B8JA 2VQRA 5LIAA 2D1GA 3T01A 3UN5A 1KHJA 2GA3A 3WAYA 1N2KA 3MK0A 4KJGA 4CXKA 2G9YA 2ANHA 4UPHA 4GTYA 3Q3QA 4KAYA 3TG0A 2IUCA 1E1ZP 2IFYA 4KAVA 1KH9A 4CXUA 1Y7AA 3DYCA 3M8WA 1AJAA 3IGYB 3BDGB 4ZGAA 4LRAA 3BDGA 1URBA 2W8DA 5DLTA 4YR1A 1HQAA 1O99A 4FDIA 1AJBA 1EQJA 1KHLA 4MY4A 2W5QA 2W5WA 1ELZA 2W5SA 3M8ZA 4LREA 5INHA 3TX0A 4ZG6A 1ALIA 1ALJA 1ALHA 2XR9A 5GOVA 3UN3A 4KM4A 1P49A 3WAXA 2X98A 2IUCB 1KH5A 4CYRA 1AJCA 5EGEA 5L0BA 3NKRA 3ED4A 3B5QA 2ZKTA 3TWZA 2QZUA 4CXSA 1ZEFA 4LR9A 1ZEDA 1ZEBA 3A52A 3NKNA 3KD8A 3NKQA 4GTZA 1E3CP 4UPIA 4CYSA 2GSNA 3SZYA 3NKOA 1URAA 5EGHA 5LQQA 1AUKA 3DPCA 3NKMA 4QAXA 4ZG9A 3UO0A 3SZZA 5K4PA 1EW9A 1KH4A 4GTXA 3IDDA 1ELXA 4LR8A 3CMRA 5L0EA 4GTWA 4TN0A 1E33P 1EW8A 4UORA 1HDHA 2XRGA 4LRFA 5TJ3A 4UPKA 5IJSA 4LRCA 3WAWA 1FSUA 3M8YA 3MK2A 5DLVA 3WAVA 1K7HA 4UPLA 1Y6VA 4B56A 1KHNA 4FDJA 1SHQA 1KHKA 2GLQA 3MK1A 4MIVA 3NVLA 3NKPA 4LRBA 3OT9A 4UOPA 3M7VA 1E2SP 2W5RA 5L0KA 2RH6A 5GRRA 2W5VA 5LRNA 4KJDA 4NWJA 3T00A 5HRTA 1N2LA 1HJKA 5DLWA 1EJJA 3UN2A 5C66A 1ANIA 3IGZB 1EI6A 3UNYA 5AJ9A 4LR7A 1ED9A 3WBHA 1ANJA 2W8SA 3BDHA 2W5TA 4ZG7A 3BDFA 1AJDA 5IJQA
chains in the Genus database with same CATH topology
4N7TA 4MHXA 1O98A 2GSOA 5LRMA 1EW2A 1ED8A 2GSUA 4LRDA 1ALKA 3T02A 3LXQA 4UOOA 5KXAA 4LQYA 4NWXA 1KH7A 4LR2A 1SHNA 1ELYA 3E2DA 2W5XA 1B8JA 2VQRA 5LIAA 2D1GA 3T01A 3UN5A 1KHJA 2GA3A 3WAYA 1N2KA 3MK0A 4KJGA 4CXKA 2G9YA 2ANHA 4UPHA 4GTYA 3Q3QA 4KAYA 3TG0A 2IUCA 1E1ZP 2IFYA 4KAVA 1KH9A 4CXUA 1Y7AA 3DYCA 3M8WA 1AJAA 3IGYB 3BDGB 4ZGAA 4LRAA 3BDGA 1URBA 2W8DA 5DLTA 4YR1A 1HQAA 1O99A 4FDIA 1AJBA 1EQJA 1KHLA 4MY4A 2W5QA 2W5WA 1ELZA 2W5SA 3M8ZA 4LREA 5INHA 3TX0A 4ZG6A 1ALIA 1ALJA 1ALHA 2XR9A 5GOVA 3UN3A 4KM4A 1P49A 3WAXA 2X98A 2IUCB 1KH5A 4CYRA 1AJCA 5EGEA 5L0BA 3NKRA 3ED4A 3B5QA 2ZKTA 3TWZA 2QZUA 4CXSA 1ZEFA 4LR9A 1ZEDA 1ZEBA 3A52A 3NKNA 3KD8A 3NKQA 4GTZA 1E3CP 4UPIA 4CYSA 2GSNA 3SZYA 3NKOA 1URAA 5EGHA 5LQQA 1AUKA 3DPCA 3NKMA 4QAXA 4ZG9A 3UO0A 3SZZA 5K4PA 1EW9A 1KH4A 4GTXA 3IDDA 1ELXA 4LR8A 3CMRA 5L0EA 4GTWA 4TN0A 1E33P 1EW8A 4UORA 1HDHA 2XRGA 4LRFA 5TJ3A 4UPKA 5IJSA 4LRCA 3WAWA 1FSUA 3M8YA 3MK2A 5DLVA 3WAVA 1K7HA 4UPLA 1Y6VA 4B56A 1KHNA 4FDJA 1SHQA 1KHKA 2GLQA 3MK1A 4MIVA 3NVLA 3NKPA 4LRBA 3OT9A 4UOPA 3M7VA 1E2SP 2W5RA 5L0KA 2RH6A 5GRRA 2W5VA 5LRNA 4KJDA 4NWJA 3T00A 5HRTA 1N2LA 1HJKA 5DLWA 1EJJA 3UN2A 5C66A 1ANIA 3IGZB 1EI6A 3UNYA 5AJ9A 4LR7A 1ED9A 3WBHA 1ANJA 2W8SA 3BDHA 2W5TA 4ZG7A 3BDFA 1AJDA 5IJQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4N7T A;  4MHX A;  1O98 A;  2GSO A;  5LRM A;  1EW2 A;  1ED8 A;  2GSU A;  4LRD A;  1ALK A;  3T02 A;  3LXQ A;  4UOO A;  5KXA A;  4LQY A;  4NWX A;  1KH7 A;  4LR2 A;  1SHN A;  1ELY A;  3E2D A;  2W5X A;  1B8J A;  2VQR A;  5LIA A;  2D1G A;  3T01 A;  3UN5 A;  1KHJ A;  2GA3 A;  3WAY A;  1N2K A;  3MK0 A;  4KJG A;  4CXK A;  2G9Y A;  2ANH A;  4UPH A;  4GTY A;  3Q3Q A;  4KAY A;  3TG0 A;  2IUC A;  1E1Z P;  2IFY A;  4KAV A;  1KH9 A;  4CXU A;  1Y7A A;  3DYC A;  3M8W A;  1AJA A;  3IGY B;  3BDG B;  4ZGA A;  4LRA A;  3BDG A;  1URB A;  2W8D A;  5DLT A;  4YR1 A;  1HQA A;  1O99 A;  4FDI A;  1AJB A;  1EQJ A;  1KHL A;  4MY4 A;  2W5Q A;  2W5W A;  1ELZ A;  2W5S A;  3M8Z A;  4LRE A;  5INH A;  3TX0 A;  4ZG6 A;  1ALI A;  1ALJ A;  1ALH A;  2XR9 A;  5GOV A;  3UN3 A;  4KM4 A;  1P49 A;  3WAX A;  2X98 A;  2IUC B;  1KH5 A;  4CYR A;  1AJC A;  5EGE A;  5L0B A;  3NKR A;  3ED4 A;  3B5Q A;  2ZKT A;  3TWZ A;  2QZU A;  4CXS A;  1ZEF A;  4LR9 A;  1ZED A;  1ZEB A;  3A52 A;  3NKN A;  3KD8 A;  3NKQ A;  4GTZ A;  1E3C P;  4UPI A;  4CYS A;  2GSN A;  3SZY A;  3NKO A;  1URA A;  5EGH A;  5LQQ A;  1AUK A;  3DPC A;  3NKM A;  4QAX A;  4ZG9 A;  3UO0 A;  3SZZ A;  5K4P A;  1EW9 A;  1KH4 A;  4GTX A;  3IDD A;  1ELX A;  4LR8 A;  3CMR A;  5L0E A;  4GTW A;  4TN0 A;  1E33 P;  1EW8 A;  4UOR A;  1HDH A;  2XRG A;  4LRF A;  5TJ3 A;  4UPK A;  5IJS A;  4LRC A;  3WAW A;  1FSU A;  3M8Y A;  3MK2 A;  5DLV A;  3WAV A;  1K7H A;  4UPL A;  1Y6V A;  4B56 A;  1KHN A;  4FDJ A;  1SHQ A;  1KHK A;  2GLQ A;  3MK1 A;  4MIV A;  3NVL A;  3NKP A;  4LRB A;  3OT9 A;  4UOP A;  3M7V A;  1E2S P;  2W5R A;  5L0K A;  2RH6 A;  5GRR A;  2W5V A;  5LRN A;  4KJD A;  4NWJ A;  3T00 A;  5HRT A;  1N2L A;  1HJK A;  5DLW A;  1EJJ A;  3UN2 A;  5C66 A;  1ANI A;  3IGZ B;  1EI6 A;  3UNY A;  5AJ9 A;  4LR7 A;  1ED9 A;  3WBH A;  1ANJ A;  2W8S A;  3BDH A;  2W5T A;  4ZG7 A;  3BDF A;  1AJD A;  5IJQ A; 
#chains in the Genus database with same CATH topology
 4N7T A;  4MHX A;  1O98 A;  2GSO A;  5LRM A;  1EW2 A;  1ED8 A;  2GSU A;  4LRD A;  1ALK A;  3T02 A;  3LXQ A;  4UOO A;  5KXA A;  4LQY A;  4NWX A;  1KH7 A;  4LR2 A;  1SHN A;  1ELY A;  3E2D A;  2W5X A;  1B8J A;  2VQR A;  5LIA A;  2D1G A;  3T01 A;  3UN5 A;  1KHJ A;  2GA3 A;  3WAY A;  1N2K A;  3MK0 A;  4KJG A;  4CXK A;  2G9Y A;  2ANH A;  4UPH A;  4GTY A;  3Q3Q A;  4KAY A;  3TG0 A;  2IUC A;  1E1Z P;  2IFY A;  4KAV A;  1KH9 A;  4CXU A;  1Y7A A;  3DYC A;  3M8W A;  1AJA A;  3IGY B;  3BDG B;  4ZGA A;  4LRA A;  3BDG A;  1URB A;  2W8D A;  5DLT A;  4YR1 A;  1HQA A;  1O99 A;  4FDI A;  1AJB A;  1EQJ A;  1KHL A;  4MY4 A;  2W5Q A;  2W5W A;  1ELZ A;  2W5S A;  3M8Z A;  4LRE A;  5INH A;  3TX0 A;  4ZG6 A;  1ALI A;  1ALJ A;  1ALH A;  2XR9 A;  5GOV A;  3UN3 A;  4KM4 A;  1P49 A;  3WAX A;  2X98 A;  2IUC B;  1KH5 A;  4CYR A;  1AJC A;  5EGE A;  5L0B A;  3NKR A;  3ED4 A;  3B5Q A;  2ZKT A;  3TWZ A;  2QZU A;  4CXS A;  1ZEF A;  4LR9 A;  1ZED A;  1ZEB A;  3A52 A;  3NKN A;  3KD8 A;  3NKQ A;  4GTZ A;  1E3C P;  4UPI A;  4CYS A;  2GSN A;  3SZY A;  3NKO A;  1URA A;  5EGH A;  5LQQ A;  1AUK A;  3DPC A;  3NKM A;  4QAX A;  4ZG9 A;  3UO0 A;  3SZZ A;  5K4P A;  1EW9 A;  1KH4 A;  4GTX A;  3IDD A;  1ELX A;  4LR8 A;  3CMR A;  5L0E A;  4GTW A;  4TN0 A;  1E33 P;  1EW8 A;  4UOR A;  1HDH A;  2XRG A;  4LRF A;  5TJ3 A;  4UPK A;  5IJS A;  4LRC A;  3WAW A;  1FSU A;  3M8Y A;  3MK2 A;  5DLV A;  3WAV A;  1K7H A;  4UPL A;  1Y6V A;  4B56 A;  1KHN A;  4FDJ A;  1SHQ A;  1KHK A;  2GLQ A;  3MK1 A;  4MIV A;  3NVL A;  3NKP A;  4LRB A;  3OT9 A;  4UOP A;  3M7V A;  1E2S P;  2W5R A;  5L0K A;  2RH6 A;  5GRR A;  2W5V A;  5LRN A;  4KJD A;  4NWJ A;  3T00 A;  5HRT A;  1N2L A;  1HJK A;  5DLW A;  1EJJ A;  3UN2 A;  5C66 A;  1ANI A;  3IGZ B;  1EI6 A;  3UNY A;  5AJ9 A;  4LR7 A;  1ED9 A;  3WBH A;  1ANJ A;  2W8S A;  3BDH A;  2W5T A;  4ZG7 A;  3BDF A;  1AJD A;  5IJQ A; 
#chains in the Genus database with same CATH homology
 4N7T A;  4MHX A;  1O98 A;  2GSO A;  5LRM A;  1EW2 A;  1ED8 A;  2GSU A;  4LRD A;  1ALK A;  3T02 A;  3LXQ A;  4UOO A;  5KXA A;  4LQY A;  4NWX A;  1KH7 A;  4LR2 A;  1SHN A;  1ELY A;  3E2D A;  2W5X A;  1B8J A;  2VQR A;  5LIA A;  2D1G A;  3T01 A;  3UN5 A;  1KHJ A;  2GA3 A;  3WAY A;  1N2K A;  3MK0 A;  4KJG A;  4CXK A;  2G9Y A;  2ANH A;  4UPH A;  4GTY A;  3Q3Q A;  4KAY A;  3TG0 A;  2IUC A;  1E1Z P;  2IFY A;  4KAV A;  1KH9 A;  4CXU A;  1Y7A A;  3DYC A;  3M8W A;  1AJA A;  3IGY B;  3BDG B;  4ZGA A;  4LRA A;  3BDG A;  1URB A;  2W8D A;  5DLT A;  4YR1 A;  1HQA A;  1O99 A;  4FDI A;  1AJB A;  1EQJ A;  1KHL A;  4MY4 A;  2W5Q A;  2W5W A;  1ELZ A;  2W5S A;  3M8Z A;  4LRE A;  5INH A;  3TX0 A;  4ZG6 A;  1ALI A;  1ALJ A;  1ALH A;  2XR9 A;  5GOV A;  3UN3 A;  4KM4 A;  1P49 A;  3WAX A;  2X98 A;  2IUC B;  1KH5 A;  4CYR A;  1AJC A;  5EGE A;  5L0B A;  3NKR A;  3ED4 A;  3B5Q A;  2ZKT A;  3TWZ A;  2QZU A;  4CXS A;  1ZEF A;  4LR9 A;  1ZED A;  1ZEB A;  3A52 A;  3NKN A;  3KD8 A;  3NKQ A;  4GTZ A;  1E3C P;  4UPI A;  4CYS A;  2GSN A;  3SZY A;  3NKO A;  1URA A;  5EGH A;  5LQQ A;  1AUK A;  3DPC A;  3NKM A;  4QAX A;  4ZG9 A;  3UO0 A;  3SZZ A;  5K4P A;  1EW9 A;  1KH4 A;  4GTX A;  3IDD A;  1ELX A;  4LR8 A;  3CMR A;  5L0E A;  4GTW A;  4TN0 A;  1E33 P;  1EW8 A;  4UOR A;  1HDH A;  2XRG A;  4LRF A;  5TJ3 A;  4UPK A;  5IJS A;  4LRC A;  3WAW A;  1FSU A;  3M8Y A;  3MK2 A;  5DLV A;  3WAV A;  1K7H A;  4UPL A;  1Y6V A;  4B56 A;  1KHN A;  4FDJ A;  1SHQ A;  1KHK A;  2GLQ A;  3MK1 A;  4MIV A;  3NVL A;  3NKP A;  4LRB A;  3OT9 A;  4UOP A;  3M7V A;  1E2S P;  2W5R A;  5L0K A;  2RH6 A;  5GRR A;  2W5V A;  5LRN A;  4KJD A;  4NWJ A;  3T00 A;  5HRT A;  1N2L A;  1HJK A;  5DLW A;  1EJJ A;  3UN2 A;  5C66 A;  1ANI A;  3IGZ B;  1EI6 A;  3UNY A;  5AJ9 A;  4LR7 A;  1ED9 A;  3WBH A;  1ANJ A;  2W8S A;  3BDH A;  2W5T A;  4ZG7 A;  3BDF A;  1AJD A;  5IJQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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