1AJDA

Three-dimensional structure of the d153g mutant of e. coli alkaline phosphatase: a mutant with weaker magnesium binding and increased catalytic activity
Total Genus 153
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
153
Knots found
sequence length
449
structure length
449
Chain Sequence
b'TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE INTERMEDIATE II OF HOLO ENZYME
publication title Crystallographic analysis of reversible metal binding observed in a mutant (Asp153-->Gly) of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Non specific mono-esterase
total genus 153
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-08-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ajdA00
5EGHA 4ZGAA 5DLVA 1N2KA 2RH6A 2ANHA 4KJDA 3UNYA 4B56A 4UOPA 4GTWA 3BDGB 4KAYA 3T00A 5LQQA 1ALJA 1KH7A 1ELYA 2W5RA 2GSOA 4UPIA 1EJJA 1ED8A 4FDIA 4KM4A 3B5QA 4GTZA 1EW9A 2D1GA 2X98A 5IJSA 1EQJA 2IFYA 2GA3A 5L0KA 5GOVA 5L0EA 1FSUA 1ZEDA 3WAYA 3BDGA 3E2DA 3NVLA 1E2SP 2GSUA 1URBA 3ED4A 3WAVA 3Q3QA 3MK1A 4MY4A 2W5WA 1Y6VA 4MHXA 3NKNA 4CYSA 3UN5A 2VQRA 3NKPA 3NKMA 1AJBA 1EI6A 2W5SA 4UPKA 1ALIA 2W5QA 3WAXA 5LRMA 3MK0A 2XR9A 1AJDA 5LIAA 3BDHA 4LR7A 2IUCB 3TWZA 2W5VA 1ZEBA 4LR2A 5DLWA 5IJQA 1HDHA 3LXQA 5AJ9A 4MIVA 3IGZB 4NWJA 3NKQA 1ZEFA 5EGEA 4TN0A 5GRRA 2ZKTA 2G9YA 3T01A 5DLTA 4LRDA 4CXUA 2XRGA 3CMRA 4QAXA 1Y7AA 1KH5A 5TJ3A 3UN2A 1ANJA 4N7TA 4LRCA 2GLQA 4LRFA 4UORA 3DPCA 3MK2A 3IDDA 4CXKA 4LQYA 1ELZA 1SHNA 3DYCA 3IGYB 4LRAA 3TX0A 3UN3A 3WAWA 2W5TA 4ZG6A 1E3CP 1KHKA 4ZG7A 3A52A 2W8DA 1N2LA 1ELXA 5INHA 1EW8A 2QZUA 3M8YA 1E33P 2W5XA 4UPHA 4ZG9A 1P49A 4LR9A 2GSNA 4UOOA 2W8SA 4LR8A 4NWXA 1HJKA 1KHLA 4LRBA 3UO0A 3BDFA 3M8WA 1URAA 5HRTA 1ED9A 3T02A 3OT9A 1SHQA 3WBHA 2IUCA 1ANIA 4CYRA 3SZZA 3NKRA 5K4PA 1K7HA 4GTYA 1ALHA 5L0BA 4GTXA 5C66A 1O99A 1KH9A 1EW2A 3NKOA 3SZYA 1ALKA 4CXSA 3KD8A 1O98A 1B8JA 4LREA 4KAVA 1AUKA 1E1ZP 1KH4A 3M7VA 4KJGA 4UPLA 4FDJA 5LRNA 3TG0A 5KXAA 3M8ZA 1HQAA 1AJCA 4YR1A 1AJAA 1KHNA 1KHJA
chains in the Genus database with same CATH superfamily
5EGHA 4ZGAA 5DLVA 1N2KA 2RH6A 2ANHA 4KJDA 3UNYA 4B56A 4UOPA 4GTWA 3BDGB 4KAYA 3T00A 5LQQA 1ALJA 1KH7A 1ELYA 2W5RA 2GSOA 4UPIA 1EJJA 1ED8A 4FDIA 4KM4A 3B5QA 4GTZA 1EW9A 2D1GA 2X98A 5IJSA 1EQJA 2IFYA 2GA3A 5L0KA 5GOVA 5L0EA 1FSUA 1ZEDA 3WAYA 3BDGA 3E2DA 3NVLA 1E2SP 2GSUA 1URBA 3ED4A 3WAVA 3Q3QA 3MK1A 4MY4A 2W5WA 1Y6VA 4MHXA 3NKNA 4CYSA 3UN5A 2VQRA 3NKPA 3NKMA 1AJBA 1EI6A 2W5SA 4UPKA 1ALIA 2W5QA 3WAXA 5LRMA 3MK0A 2XR9A 1AJDA 5LIAA 3BDHA 4LR7A 2IUCB 3TWZA 2W5VA 1ZEBA 4LR2A 5DLWA 5IJQA 1HDHA 3LXQA 5AJ9A 4MIVA 3IGZB 4NWJA 3NKQA 1ZEFA 5EGEA 4TN0A 5GRRA 2ZKTA 2G9YA 3T01A 5DLTA 4LRDA 4CXUA 2XRGA 3CMRA 4QAXA 1Y7AA 1KH5A 5TJ3A 3UN2A 1ANJA 4N7TA 4LRCA 2GLQA 4LRFA 4UORA 3DPCA 3MK2A 3IDDA 4CXKA 4LQYA 1ELZA 1SHNA 3DYCA 3IGYB 4LRAA 3TX0A 3UN3A 3WAWA 2W5TA 4ZG6A 1E3CP 1KHKA 4ZG7A 3A52A 2W8DA 1N2LA 1ELXA 5INHA 1EW8A 2QZUA 3M8YA 1E33P 2W5XA 4UPHA 4ZG9A 1P49A 4LR9A 2GSNA 4UOOA 2W8SA 4LR8A 4NWXA 1HJKA 1KHLA 4LRBA 3UO0A 3BDFA 3M8WA 1URAA 5HRTA 1ED9A 3T02A 3OT9A 1SHQA 3WBHA 2IUCA 1ANIA 4CYRA 3SZZA 3NKRA 5K4PA 1K7HA 4GTYA 1ALHA 5L0BA 4GTXA 5C66A 1O99A 1KH9A 1EW2A 3NKOA 3SZYA 1ALKA 4CXSA 3KD8A 1O98A 1B8JA 4LREA 4KAVA 1AUKA 1E1ZP 1KH4A 3M7VA 4KJGA 4UPLA 4FDJA 5LRNA 3TG0A 5KXAA 3M8ZA 1HQAA 1AJCA 4YR1A 1AJAA 1KHNA 1KHJA
chains in the Genus database with same CATH topology
5EGHA 4ZGAA 5DLVA 1N2KA 2RH6A 2ANHA 4KJDA 3UNYA 4B56A 4UOPA 4GTWA 3BDGB 4KAYA 3T00A 5LQQA 1ALJA 1KH7A 1ELYA 2W5RA 2GSOA 4UPIA 1EJJA 1ED8A 4FDIA 4KM4A 3B5QA 4GTZA 1EW9A 2D1GA 2X98A 5IJSA 1EQJA 2IFYA 2GA3A 5L0KA 5GOVA 5L0EA 1FSUA 1ZEDA 3WAYA 3BDGA 3E2DA 3NVLA 1E2SP 2GSUA 1URBA 3ED4A 3WAVA 3Q3QA 3MK1A 4MY4A 2W5WA 1Y6VA 4MHXA 3NKNA 4CYSA 3UN5A 2VQRA 3NKPA 3NKMA 1AJBA 1EI6A 2W5SA 4UPKA 1ALIA 2W5QA 3WAXA 5LRMA 3MK0A 2XR9A 1AJDA 5LIAA 3BDHA 4LR7A 2IUCB 3TWZA 2W5VA 1ZEBA 4LR2A 5DLWA 5IJQA 1HDHA 3LXQA 5AJ9A 4MIVA 3IGZB 4NWJA 3NKQA 1ZEFA 5EGEA 4TN0A 5GRRA 2ZKTA 2G9YA 3T01A 5DLTA 4LRDA 4CXUA 2XRGA 3CMRA 4QAXA 1Y7AA 1KH5A 5TJ3A 3UN2A 1ANJA 4N7TA 4LRCA 2GLQA 4LRFA 4UORA 3DPCA 3MK2A 3IDDA 4CXKA 4LQYA 1ELZA 1SHNA 3DYCA 3IGYB 4LRAA 3TX0A 3UN3A 3WAWA 2W5TA 4ZG6A 1E3CP 1KHKA 4ZG7A 3A52A 2W8DA 1N2LA 1ELXA 5INHA 1EW8A 2QZUA 3M8YA 1E33P 2W5XA 4UPHA 4ZG9A 1P49A 4LR9A 2GSNA 4UOOA 2W8SA 4LR8A 4NWXA 1HJKA 1KHLA 4LRBA 3UO0A 3BDFA 3M8WA 1URAA 5HRTA 1ED9A 3T02A 3OT9A 1SHQA 3WBHA 2IUCA 1ANIA 4CYRA 3SZZA 3NKRA 5K4PA 1K7HA 4GTYA 1ALHA 5L0BA 4GTXA 5C66A 1O99A 1KH9A 1EW2A 3NKOA 3SZYA 1ALKA 4CXSA 3KD8A 1O98A 1B8JA 4LREA 4KAVA 1AUKA 1E1ZP 1KH4A 3M7VA 4KJGA 4UPLA 4FDJA 5LRNA 3TG0A 5KXAA 3M8ZA 1HQAA 1AJCA 4YR1A 1AJAA 1KHNA 1KHJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5EGH A;  4ZGA A;  5DLV A;  1N2K A;  2RH6 A;  2ANH A;  4KJD A;  3UNY A;  4B56 A;  4UOP A;  4GTW A;  3BDG B;  4KAY A;  3T00 A;  5LQQ A;  1ALJ A;  1KH7 A;  1ELY A;  2W5R A;  2GSO A;  4UPI A;  1EJJ A;  1ED8 A;  4FDI A;  4KM4 A;  3B5Q A;  4GTZ A;  1EW9 A;  2D1G A;  2X98 A;  5IJS A;  1EQJ A;  2IFY A;  2GA3 A;  5L0K A;  5GOV A;  5L0E A;  1FSU A;  1ZED A;  3WAY A;  3BDG A;  3E2D A;  3NVL A;  1E2S P;  2GSU A;  1URB A;  3ED4 A;  3WAV A;  3Q3Q A;  3MK1 A;  4MY4 A;  2W5W A;  1Y6V A;  4MHX A;  3NKN A;  4CYS A;  3UN5 A;  2VQR A;  3NKP A;  3NKM A;  1AJB A;  1EI6 A;  2W5S A;  4UPK A;  1ALI A;  2W5Q A;  3WAX A;  5LRM A;  3MK0 A;  2XR9 A;  1AJD A;  5LIA A;  3BDH A;  4LR7 A;  2IUC B;  3TWZ A;  2W5V A;  1ZEB A;  4LR2 A;  5DLW A;  5IJQ A;  1HDH A;  3LXQ A;  5AJ9 A;  4MIV A;  3IGZ B;  4NWJ A;  3NKQ A;  1ZEF A;  5EGE A;  4TN0 A;  5GRR A;  2ZKT A;  2G9Y A;  3T01 A;  5DLT A;  4LRD A;  4CXU A;  2XRG A;  3CMR A;  4QAX A;  1Y7A A;  1KH5 A;  5TJ3 A;  3UN2 A;  1ANJ A;  4N7T A;  4LRC A;  2GLQ A;  4LRF A;  4UOR A;  3DPC A;  3MK2 A;  3IDD A;  4CXK A;  4LQY A;  1ELZ A;  1SHN A;  3DYC A;  3IGY B;  4LRA A;  3TX0 A;  3UN3 A;  3WAW A;  2W5T A;  4ZG6 A;  1E3C P;  1KHK A;  4ZG7 A;  3A52 A;  2W8D A;  1N2L A;  1ELX A;  5INH A;  1EW8 A;  2QZU A;  3M8Y A;  1E33 P;  2W5X A;  4UPH A;  4ZG9 A;  1P49 A;  4LR9 A;  2GSN A;  4UOO A;  2W8S A;  4LR8 A;  4NWX A;  1HJK A;  1KHL A;  4LRB A;  3UO0 A;  3BDF A;  3M8W A;  1URA A;  5HRT A;  1ED9 A;  3T02 A;  3OT9 A;  1SHQ A;  3WBH A;  2IUC A;  1ANI A;  4CYR A;  3SZZ A;  3NKR A;  5K4P A;  1K7H A;  4GTY A;  1ALH A;  5L0B A;  4GTX A;  5C66 A;  1O99 A;  1KH9 A;  1EW2 A;  3NKO A;  3SZY A;  1ALK A;  4CXS A;  3KD8 A;  1O98 A;  1B8J A;  4LRE A;  4KAV A;  1AUK A;  1E1Z P;  1KH4 A;  3M7V A;  4KJG A;  4UPL A;  4FDJ A;  5LRN A;  3TG0 A;  5KXA A;  3M8Z A;  1HQA A;  1AJC A;  4YR1 A;  1AJA A;  1KHN A;  1KHJ A; 
#chains in the Genus database with same CATH topology
 5EGH A;  4ZGA A;  5DLV A;  1N2K A;  2RH6 A;  2ANH A;  4KJD A;  3UNY A;  4B56 A;  4UOP A;  4GTW A;  3BDG B;  4KAY A;  3T00 A;  5LQQ A;  1ALJ A;  1KH7 A;  1ELY A;  2W5R A;  2GSO A;  4UPI A;  1EJJ A;  1ED8 A;  4FDI A;  4KM4 A;  3B5Q A;  4GTZ A;  1EW9 A;  2D1G A;  2X98 A;  5IJS A;  1EQJ A;  2IFY A;  2GA3 A;  5L0K A;  5GOV A;  5L0E A;  1FSU A;  1ZED A;  3WAY A;  3BDG A;  3E2D A;  3NVL A;  1E2S P;  2GSU A;  1URB A;  3ED4 A;  3WAV A;  3Q3Q A;  3MK1 A;  4MY4 A;  2W5W A;  1Y6V A;  4MHX A;  3NKN A;  4CYS A;  3UN5 A;  2VQR A;  3NKP A;  3NKM A;  1AJB A;  1EI6 A;  2W5S A;  4UPK A;  1ALI A;  2W5Q A;  3WAX A;  5LRM A;  3MK0 A;  2XR9 A;  1AJD A;  5LIA A;  3BDH A;  4LR7 A;  2IUC B;  3TWZ A;  2W5V A;  1ZEB A;  4LR2 A;  5DLW A;  5IJQ A;  1HDH A;  3LXQ A;  5AJ9 A;  4MIV A;  3IGZ B;  4NWJ A;  3NKQ A;  1ZEF A;  5EGE A;  4TN0 A;  5GRR A;  2ZKT A;  2G9Y A;  3T01 A;  5DLT A;  4LRD A;  4CXU A;  2XRG A;  3CMR A;  4QAX A;  1Y7A A;  1KH5 A;  5TJ3 A;  3UN2 A;  1ANJ A;  4N7T A;  4LRC A;  2GLQ A;  4LRF A;  4UOR A;  3DPC A;  3MK2 A;  3IDD A;  4CXK A;  4LQY A;  1ELZ A;  1SHN A;  3DYC A;  3IGY B;  4LRA A;  3TX0 A;  3UN3 A;  3WAW A;  2W5T A;  4ZG6 A;  1E3C P;  1KHK A;  4ZG7 A;  3A52 A;  2W8D A;  1N2L A;  1ELX A;  5INH A;  1EW8 A;  2QZU A;  3M8Y A;  1E33 P;  2W5X A;  4UPH A;  4ZG9 A;  1P49 A;  4LR9 A;  2GSN A;  4UOO A;  2W8S A;  4LR8 A;  4NWX A;  1HJK A;  1KHL A;  4LRB A;  3UO0 A;  3BDF A;  3M8W A;  1URA A;  5HRT A;  1ED9 A;  3T02 A;  3OT9 A;  1SHQ A;  3WBH A;  2IUC A;  1ANI A;  4CYR A;  3SZZ A;  3NKR A;  5K4P A;  1K7H A;  4GTY A;  1ALH A;  5L0B A;  4GTX A;  5C66 A;  1O99 A;  1KH9 A;  1EW2 A;  3NKO A;  3SZY A;  1ALK A;  4CXS A;  3KD8 A;  1O98 A;  1B8J A;  4LRE A;  4KAV A;  1AUK A;  1E1Z P;  1KH4 A;  3M7V A;  4KJG A;  4UPL A;  4FDJ A;  5LRN A;  3TG0 A;  5KXA A;  3M8Z A;  1HQA A;  1AJC A;  4YR1 A;  1AJA A;  1KHN A;  1KHJ A; 
#chains in the Genus database with same CATH homology
 5EGH A;  4ZGA A;  5DLV A;  1N2K A;  2RH6 A;  2ANH A;  4KJD A;  3UNY A;  4B56 A;  4UOP A;  4GTW A;  3BDG B;  4KAY A;  3T00 A;  5LQQ A;  1ALJ A;  1KH7 A;  1ELY A;  2W5R A;  2GSO A;  4UPI A;  1EJJ A;  1ED8 A;  4FDI A;  4KM4 A;  3B5Q A;  4GTZ A;  1EW9 A;  2D1G A;  2X98 A;  5IJS A;  1EQJ A;  2IFY A;  2GA3 A;  5L0K A;  5GOV A;  5L0E A;  1FSU A;  1ZED A;  3WAY A;  3BDG A;  3E2D A;  3NVL A;  1E2S P;  2GSU A;  1URB A;  3ED4 A;  3WAV A;  3Q3Q A;  3MK1 A;  4MY4 A;  2W5W A;  1Y6V A;  4MHX A;  3NKN A;  4CYS A;  3UN5 A;  2VQR A;  3NKP A;  3NKM A;  1AJB A;  1EI6 A;  2W5S A;  4UPK A;  1ALI A;  2W5Q A;  3WAX A;  5LRM A;  3MK0 A;  2XR9 A;  1AJD A;  5LIA A;  3BDH A;  4LR7 A;  2IUC B;  3TWZ A;  2W5V A;  1ZEB A;  4LR2 A;  5DLW A;  5IJQ A;  1HDH A;  3LXQ A;  5AJ9 A;  4MIV A;  3IGZ B;  4NWJ A;  3NKQ A;  1ZEF A;  5EGE A;  4TN0 A;  5GRR A;  2ZKT A;  2G9Y A;  3T01 A;  5DLT A;  4LRD A;  4CXU A;  2XRG A;  3CMR A;  4QAX A;  1Y7A A;  1KH5 A;  5TJ3 A;  3UN2 A;  1ANJ A;  4N7T A;  4LRC A;  2GLQ A;  4LRF A;  4UOR A;  3DPC A;  3MK2 A;  3IDD A;  4CXK A;  4LQY A;  1ELZ A;  1SHN A;  3DYC A;  3IGY B;  4LRA A;  3TX0 A;  3UN3 A;  3WAW A;  2W5T A;  4ZG6 A;  1E3C P;  1KHK A;  4ZG7 A;  3A52 A;  2W8D A;  1N2L A;  1ELX A;  5INH A;  1EW8 A;  2QZU A;  3M8Y A;  1E33 P;  2W5X A;  4UPH A;  4ZG9 A;  1P49 A;  4LR9 A;  2GSN A;  4UOO A;  2W8S A;  4LR8 A;  4NWX A;  1HJK A;  1KHL A;  4LRB A;  3UO0 A;  3BDF A;  3M8W A;  1URA A;  5HRT A;  1ED9 A;  3T02 A;  3OT9 A;  1SHQ A;  3WBH A;  2IUC A;  1ANI A;  4CYR A;  3SZZ A;  3NKR A;  5K4P A;  1K7H A;  4GTY A;  1ALH A;  5L0B A;  4GTX A;  5C66 A;  1O99 A;  1KH9 A;  1EW2 A;  3NKO A;  3SZY A;  1ALK A;  4CXS A;  3KD8 A;  1O98 A;  1B8J A;  4LRE A;  4KAV A;  1AUK A;  1E1Z P;  1KH4 A;  3M7V A;  4KJG A;  4UPL A;  4FDJ A;  5LRN A;  3TG0 A;  5KXA A;  3M8Z A;  1HQA A;  1AJC A;  4YR1 A;  1AJA A;  1KHN A;  1KHJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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