1ALIA

Alkaline phosphatase mutant (h412n)
Total Genus 162
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
162
Knots found
sequence length
446
structure length
446
Chain Sequence
b'MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQENTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Escherichia coli alkaline phosphatase: X-ray structural studies of a mutant enzyme (His-412-->Asn) at one of the catalytically important zinc binding sites.
pubmed rcsb
source organism Escherichia coli
molecule tags Hydrolase (phosphoric monoester)
total genus 162
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-06-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1aliA00
2XR9A 2W5RA 4ZGAA 3KD8A 1KH5A 4LRDA 4KAVA 3TX0A 2ANHA 3UN3A 1ED9A 5GRRA 1KHLA 3WBHA 3WAXA 4KJDA 5EGEA 3M8ZA 3IGZB 5LQQA 4CYRA 5L0KA 1KHJA 1ALJA 4NWXA 5IJSA 5LRMA 3DYCA 4FDJA 1ELZA 3M7VA 3NKQA 4N7TA 3T01A 1EQJA 4LREA 4UOPA 4LR9A 5K4PA 1SHQA 3M8WA 3MK1A 3ED4A 3WAVA 1ZEDA 1Y6VA 1E33P 5C66A 1EW9A 4UORA 3WAWA 3WAYA 1E3CP 1AJBA 2D1GA 4UPLA 3NKMA 5GOVA 1Y7AA 3Q3QA 3BDGB 3UO0A 2W8DA 5IJQA 4QAXA 4ZG7A 4GTYA 3UN2A 2GLQA 3UN5A 5KXAA 5L0BA 1ALIA 1AJDA 2GSUA 4B56A 5LIAA 2IUCA 5DLTA 1ZEFA 3TWZA 3MK2A 3NKOA 3T00A 2GSOA 1FSUA 1KH4A 1ALKA 1ZEBA 1EJJA 4CXSA 3NKPA 3T02A 1EW2A 2W5QA 2IUCB 1E2SP 2GSNA 4FDIA 1P49A 3SZYA 5TJ3A 4MIVA 4LR7A 4LR2A 4CXUA 3IGYB 2GA3A 4KM4A 1O98A 2W5XA 5HRTA 1ALHA 4MY4A 3IDDA 2XRGA 5EGHA 1ANJA 2RH6A 4LRBA 2W5TA 1ED8A 3MK0A 2QZUA 4NWJA 4LRAA 4LRFA 4TN0A 4GTWA 1B8JA 2W5SA 4UPKA 4KJGA 3BDHA 4ZG9A 4LQYA 4UPIA 2IFYA 3NKRA 3NKNA 3TG0A 1ELXA 3DPCA 1EW8A 5L0EA 1N2KA 1URAA 2W5WA 3OT9A 3B5QA 5INHA 1N2LA 1SHNA 2G9YA 3NVLA 4CXKA 1ANIA 1AJCA 1KH9A 5DLVA 3BDFA 4KAYA 5DLWA 1EI6A 4GTZA 5LRNA 1HJKA 1URBA 4MHXA 3SZZA 1ELYA 1K7HA 2VQRA 3LXQA 5AJ9A 4UPHA 1KHNA 1E1ZP 1O99A 1KHKA 4CYSA 1HQAA 4LRCA 3M8YA 3UNYA 4ZG6A 3BDGA 1HDHA 1KH7A 2W5VA 4LR8A 4YR1A 3A52A 1AUKA 4UOOA 1AJAA 2X98A 4GTXA 2ZKTA 3E2DA 2W8SA 3CMRA
chains in the Genus database with same CATH superfamily
2XR9A 2W5RA 4ZGAA 3KD8A 1KH5A 4LRDA 4KAVA 3TX0A 2ANHA 3UN3A 1ED9A 5GRRA 1KHLA 3WBHA 3WAXA 4KJDA 5EGEA 3M8ZA 3IGZB 5LQQA 4CYRA 5L0KA 1KHJA 1ALJA 4NWXA 5IJSA 5LRMA 3DYCA 4FDJA 1ELZA 3M7VA 3NKQA 4N7TA 3T01A 1EQJA 4LREA 4UOPA 4LR9A 5K4PA 1SHQA 3M8WA 3MK1A 3ED4A 3WAVA 1ZEDA 1Y6VA 1E33P 5C66A 1EW9A 4UORA 3WAWA 3WAYA 1E3CP 1AJBA 2D1GA 4UPLA 3NKMA 5GOVA 1Y7AA 3Q3QA 3BDGB 3UO0A 2W8DA 5IJQA 4QAXA 4ZG7A 4GTYA 3UN2A 2GLQA 3UN5A 5KXAA 5L0BA 1ALIA 1AJDA 2GSUA 4B56A 5LIAA 2IUCA 5DLTA 1ZEFA 3TWZA 3MK2A 3NKOA 3T00A 2GSOA 1FSUA 1KH4A 1ALKA 1ZEBA 1EJJA 4CXSA 3NKPA 3T02A 1EW2A 2W5QA 2IUCB 1E2SP 2GSNA 4FDIA 1P49A 3SZYA 5TJ3A 4MIVA 4LR7A 4LR2A 4CXUA 3IGYB 2GA3A 4KM4A 1O98A 2W5XA 5HRTA 1ALHA 4MY4A 3IDDA 2XRGA 5EGHA 1ANJA 2RH6A 4LRBA 2W5TA 1ED8A 3MK0A 2QZUA 4NWJA 4LRAA 4LRFA 4TN0A 4GTWA 1B8JA 2W5SA 4UPKA 4KJGA 3BDHA 4ZG9A 4LQYA 4UPIA 2IFYA 3NKRA 3NKNA 3TG0A 1ELXA 3DPCA 1EW8A 5L0EA 1N2KA 1URAA 2W5WA 3OT9A 3B5QA 5INHA 1N2LA 1SHNA 2G9YA 3NVLA 4CXKA 1ANIA 1AJCA 1KH9A 5DLVA 3BDFA 4KAYA 5DLWA 1EI6A 4GTZA 5LRNA 1HJKA 1URBA 4MHXA 3SZZA 1ELYA 1K7HA 2VQRA 3LXQA 5AJ9A 4UPHA 1KHNA 1E1ZP 1O99A 1KHKA 4CYSA 1HQAA 4LRCA 3M8YA 3UNYA 4ZG6A 3BDGA 1HDHA 1KH7A 2W5VA 4LR8A 4YR1A 3A52A 1AUKA 4UOOA 1AJAA 2X98A 4GTXA 2ZKTA 3E2DA 2W8SA 3CMRA
chains in the Genus database with same CATH topology
2XR9A 2W5RA 4ZGAA 3KD8A 1KH5A 4LRDA 4KAVA 3TX0A 2ANHA 3UN3A 1ED9A 5GRRA 1KHLA 3WBHA 3WAXA 4KJDA 5EGEA 3M8ZA 3IGZB 5LQQA 4CYRA 5L0KA 1KHJA 1ALJA 4NWXA 5IJSA 5LRMA 3DYCA 4FDJA 1ELZA 3M7VA 3NKQA 4N7TA 3T01A 1EQJA 4LREA 4UOPA 4LR9A 5K4PA 1SHQA 3M8WA 3MK1A 3ED4A 3WAVA 1ZEDA 1Y6VA 1E33P 5C66A 1EW9A 4UORA 3WAWA 3WAYA 1E3CP 1AJBA 2D1GA 4UPLA 3NKMA 5GOVA 1Y7AA 3Q3QA 3BDGB 3UO0A 2W8DA 5IJQA 4QAXA 4ZG7A 4GTYA 3UN2A 2GLQA 3UN5A 5KXAA 5L0BA 1ALIA 1AJDA 2GSUA 4B56A 5LIAA 2IUCA 5DLTA 1ZEFA 3TWZA 3MK2A 3NKOA 3T00A 2GSOA 1FSUA 1KH4A 1ALKA 1ZEBA 1EJJA 4CXSA 3NKPA 3T02A 1EW2A 2W5QA 2IUCB 1E2SP 2GSNA 4FDIA 1P49A 3SZYA 5TJ3A 4MIVA 4LR7A 4LR2A 4CXUA 3IGYB 2GA3A 4KM4A 1O98A 2W5XA 5HRTA 1ALHA 4MY4A 3IDDA 2XRGA 5EGHA 1ANJA 2RH6A 4LRBA 2W5TA 1ED8A 3MK0A 2QZUA 4NWJA 4LRAA 4LRFA 4TN0A 4GTWA 1B8JA 2W5SA 4UPKA 4KJGA 3BDHA 4ZG9A 4LQYA 4UPIA 2IFYA 3NKRA 3NKNA 3TG0A 1ELXA 3DPCA 1EW8A 5L0EA 1N2KA 1URAA 2W5WA 3OT9A 3B5QA 5INHA 1N2LA 1SHNA 2G9YA 3NVLA 4CXKA 1ANIA 1AJCA 1KH9A 5DLVA 3BDFA 4KAYA 5DLWA 1EI6A 4GTZA 5LRNA 1HJKA 1URBA 4MHXA 3SZZA 1ELYA 1K7HA 2VQRA 3LXQA 5AJ9A 4UPHA 1KHNA 1E1ZP 1O99A 1KHKA 4CYSA 1HQAA 4LRCA 3M8YA 3UNYA 4ZG6A 3BDGA 1HDHA 1KH7A 2W5VA 4LR8A 4YR1A 3A52A 1AUKA 4UOOA 1AJAA 2X98A 4GTXA 2ZKTA 3E2DA 2W8SA 3CMRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XR9 A;  2W5R A;  4ZGA A;  3KD8 A;  1KH5 A;  4LRD A;  4KAV A;  3TX0 A;  2ANH A;  3UN3 A;  1ED9 A;  5GRR A;  1KHL A;  3WBH A;  3WAX A;  4KJD A;  5EGE A;  3M8Z A;  3IGZ B;  5LQQ A;  4CYR A;  5L0K A;  1KHJ A;  1ALJ A;  4NWX A;  5IJS A;  5LRM A;  3DYC A;  4FDJ A;  1ELZ A;  3M7V A;  3NKQ A;  4N7T A;  3T01 A;  1EQJ A;  4LRE A;  4UOP A;  4LR9 A;  5K4P A;  1SHQ A;  3M8W A;  3MK1 A;  3ED4 A;  3WAV A;  1ZED A;  1Y6V A;  1E33 P;  5C66 A;  1EW9 A;  4UOR A;  3WAW A;  3WAY A;  1E3C P;  1AJB A;  2D1G A;  4UPL A;  3NKM A;  5GOV A;  1Y7A A;  3Q3Q A;  3BDG B;  3UO0 A;  2W8D A;  5IJQ A;  4QAX A;  4ZG7 A;  4GTY A;  3UN2 A;  2GLQ A;  3UN5 A;  5KXA A;  5L0B A;  1ALI A;  1AJD A;  2GSU A;  4B56 A;  5LIA A;  2IUC A;  5DLT A;  1ZEF A;  3TWZ A;  3MK2 A;  3NKO A;  3T00 A;  2GSO A;  1FSU A;  1KH4 A;  1ALK A;  1ZEB A;  1EJJ A;  4CXS A;  3NKP A;  3T02 A;  1EW2 A;  2W5Q A;  2IUC B;  1E2S P;  2GSN A;  4FDI A;  1P49 A;  3SZY A;  5TJ3 A;  4MIV A;  4LR7 A;  4LR2 A;  4CXU A;  3IGY B;  2GA3 A;  4KM4 A;  1O98 A;  2W5X A;  5HRT A;  1ALH A;  4MY4 A;  3IDD A;  2XRG A;  5EGH A;  1ANJ A;  2RH6 A;  4LRB A;  2W5T A;  1ED8 A;  3MK0 A;  2QZU A;  4NWJ A;  4LRA A;  4LRF A;  4TN0 A;  4GTW A;  1B8J A;  2W5S A;  4UPK A;  4KJG A;  3BDH A;  4ZG9 A;  4LQY A;  4UPI A;  2IFY A;  3NKR A;  3NKN A;  3TG0 A;  1ELX A;  3DPC A;  1EW8 A;  5L0E A;  1N2K A;  1URA A;  2W5W A;  3OT9 A;  3B5Q A;  5INH A;  1N2L A;  1SHN A;  2G9Y A;  3NVL A;  4CXK A;  1ANI A;  1AJC A;  1KH9 A;  5DLV A;  3BDF A;  4KAY A;  5DLW A;  1EI6 A;  4GTZ A;  5LRN A;  1HJK A;  1URB A;  4MHX A;  3SZZ A;  1ELY A;  1K7H A;  2VQR A;  3LXQ A;  5AJ9 A;  4UPH A;  1KHN A;  1E1Z P;  1O99 A;  1KHK A;  4CYS A;  1HQA A;  4LRC A;  3M8Y A;  3UNY A;  4ZG6 A;  3BDG A;  1HDH A;  1KH7 A;  2W5V A;  4LR8 A;  4YR1 A;  3A52 A;  1AUK A;  4UOO A;  1AJA A;  2X98 A;  4GTX A;  2ZKT A;  3E2D A;  2W8S A;  3CMR A; 
#chains in the Genus database with same CATH topology
 2XR9 A;  2W5R A;  4ZGA A;  3KD8 A;  1KH5 A;  4LRD A;  4KAV A;  3TX0 A;  2ANH A;  3UN3 A;  1ED9 A;  5GRR A;  1KHL A;  3WBH A;  3WAX A;  4KJD A;  5EGE A;  3M8Z A;  3IGZ B;  5LQQ A;  4CYR A;  5L0K A;  1KHJ A;  1ALJ A;  4NWX A;  5IJS A;  5LRM A;  3DYC A;  4FDJ A;  1ELZ A;  3M7V A;  3NKQ A;  4N7T A;  3T01 A;  1EQJ A;  4LRE A;  4UOP A;  4LR9 A;  5K4P A;  1SHQ A;  3M8W A;  3MK1 A;  3ED4 A;  3WAV A;  1ZED A;  1Y6V A;  1E33 P;  5C66 A;  1EW9 A;  4UOR A;  3WAW A;  3WAY A;  1E3C P;  1AJB A;  2D1G A;  4UPL A;  3NKM A;  5GOV A;  1Y7A A;  3Q3Q A;  3BDG B;  3UO0 A;  2W8D A;  5IJQ A;  4QAX A;  4ZG7 A;  4GTY A;  3UN2 A;  2GLQ A;  3UN5 A;  5KXA A;  5L0B A;  1ALI A;  1AJD A;  2GSU A;  4B56 A;  5LIA A;  2IUC A;  5DLT A;  1ZEF A;  3TWZ A;  3MK2 A;  3NKO A;  3T00 A;  2GSO A;  1FSU A;  1KH4 A;  1ALK A;  1ZEB A;  1EJJ A;  4CXS A;  3NKP A;  3T02 A;  1EW2 A;  2W5Q A;  2IUC B;  1E2S P;  2GSN A;  4FDI A;  1P49 A;  3SZY A;  5TJ3 A;  4MIV A;  4LR7 A;  4LR2 A;  4CXU A;  3IGY B;  2GA3 A;  4KM4 A;  1O98 A;  2W5X A;  5HRT A;  1ALH A;  4MY4 A;  3IDD A;  2XRG A;  5EGH A;  1ANJ A;  2RH6 A;  4LRB A;  2W5T A;  1ED8 A;  3MK0 A;  2QZU A;  4NWJ A;  4LRA A;  4LRF A;  4TN0 A;  4GTW A;  1B8J A;  2W5S A;  4UPK A;  4KJG A;  3BDH A;  4ZG9 A;  4LQY A;  4UPI A;  2IFY A;  3NKR A;  3NKN A;  3TG0 A;  1ELX A;  3DPC A;  1EW8 A;  5L0E A;  1N2K A;  1URA A;  2W5W A;  3OT9 A;  3B5Q A;  5INH A;  1N2L A;  1SHN A;  2G9Y A;  3NVL A;  4CXK A;  1ANI A;  1AJC A;  1KH9 A;  5DLV A;  3BDF A;  4KAY A;  5DLW A;  1EI6 A;  4GTZ A;  5LRN A;  1HJK A;  1URB A;  4MHX A;  3SZZ A;  1ELY A;  1K7H A;  2VQR A;  3LXQ A;  5AJ9 A;  4UPH A;  1KHN A;  1E1Z P;  1O99 A;  1KHK A;  4CYS A;  1HQA A;  4LRC A;  3M8Y A;  3UNY A;  4ZG6 A;  3BDG A;  1HDH A;  1KH7 A;  2W5V A;  4LR8 A;  4YR1 A;  3A52 A;  1AUK A;  4UOO A;  1AJA A;  2X98 A;  4GTX A;  2ZKT A;  3E2D A;  2W8S A;  3CMR A; 
#chains in the Genus database with same CATH homology
 2XR9 A;  2W5R A;  4ZGA A;  3KD8 A;  1KH5 A;  4LRD A;  4KAV A;  3TX0 A;  2ANH A;  3UN3 A;  1ED9 A;  5GRR A;  1KHL A;  3WBH A;  3WAX A;  4KJD A;  5EGE A;  3M8Z A;  3IGZ B;  5LQQ A;  4CYR A;  5L0K A;  1KHJ A;  1ALJ A;  4NWX A;  5IJS A;  5LRM A;  3DYC A;  4FDJ A;  1ELZ A;  3M7V A;  3NKQ A;  4N7T A;  3T01 A;  1EQJ A;  4LRE A;  4UOP A;  4LR9 A;  5K4P A;  1SHQ A;  3M8W A;  3MK1 A;  3ED4 A;  3WAV A;  1ZED A;  1Y6V A;  1E33 P;  5C66 A;  1EW9 A;  4UOR A;  3WAW A;  3WAY A;  1E3C P;  1AJB A;  2D1G A;  4UPL A;  3NKM A;  5GOV A;  1Y7A A;  3Q3Q A;  3BDG B;  3UO0 A;  2W8D A;  5IJQ A;  4QAX A;  4ZG7 A;  4GTY A;  3UN2 A;  2GLQ A;  3UN5 A;  5KXA A;  5L0B A;  1ALI A;  1AJD A;  2GSU A;  4B56 A;  5LIA A;  2IUC A;  5DLT A;  1ZEF A;  3TWZ A;  3MK2 A;  3NKO A;  3T00 A;  2GSO A;  1FSU A;  1KH4 A;  1ALK A;  1ZEB A;  1EJJ A;  4CXS A;  3NKP A;  3T02 A;  1EW2 A;  2W5Q A;  2IUC B;  1E2S P;  2GSN A;  4FDI A;  1P49 A;  3SZY A;  5TJ3 A;  4MIV A;  4LR7 A;  4LR2 A;  4CXU A;  3IGY B;  2GA3 A;  4KM4 A;  1O98 A;  2W5X A;  5HRT A;  1ALH A;  4MY4 A;  3IDD A;  2XRG A;  5EGH A;  1ANJ A;  2RH6 A;  4LRB A;  2W5T A;  1ED8 A;  3MK0 A;  2QZU A;  4NWJ A;  4LRA A;  4LRF A;  4TN0 A;  4GTW A;  1B8J A;  2W5S A;  4UPK A;  4KJG A;  3BDH A;  4ZG9 A;  4LQY A;  4UPI A;  2IFY A;  3NKR A;  3NKN A;  3TG0 A;  1ELX A;  3DPC A;  1EW8 A;  5L0E A;  1N2K A;  1URA A;  2W5W A;  3OT9 A;  3B5Q A;  5INH A;  1N2L A;  1SHN A;  2G9Y A;  3NVL A;  4CXK A;  1ANI A;  1AJC A;  1KH9 A;  5DLV A;  3BDF A;  4KAY A;  5DLW A;  1EI6 A;  4GTZ A;  5LRN A;  1HJK A;  1URB A;  4MHX A;  3SZZ A;  1ELY A;  1K7H A;  2VQR A;  3LXQ A;  5AJ9 A;  4UPH A;  1KHN A;  1E1Z P;  1O99 A;  1KHK A;  4CYS A;  1HQA A;  4LRC A;  3M8Y A;  3UNY A;  4ZG6 A;  3BDG A;  1HDH A;  1KH7 A;  2W5V A;  4LR8 A;  4YR1 A;  3A52 A;  1AUK A;  4UOO A;  1AJA A;  2X98 A;  4GTX A;  2ZKT A;  3E2D A;  2W8S A;  3CMR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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