1ANIA

Alkaline phosphatase (d153h, k328h)
Total Genus 161
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
161
Knots found
sequence length
446
structure length
446
Chain Sequence
b'MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDHQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Mutations at positions 153 and 328 in Escherichia coli alkaline phosphatase provide insight towards the structure and function of mammalian and yeast alkaline phosphatases.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Alkaline phosphatase
total genus 161
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-09-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1aniA00
2IUCB 1AJCA 3WAYA 3Q3QA 1EQJA 4LRDA 4CYSA 4LRBA 4ZGAA 2W5QA 5LRMA 2W5TA 4UORA 5HRTA 1Y6VA 5KXAA 1KH7A 3KD8A 1ALIA 2XR9A 1ELZA 5DLVA 3WAWA 5EGHA 5L0EA 1E2SP 1E1ZP 1KHJA 4GTWA 3NKPA 4UPLA 1ZEBA 4UPKA 5C66A 4ZG7A 5INHA 1URBA 4UPHA 1ANIA 1FSUA 3SZZA 3TX0A 3UN2A 1SHNA 3NKQA 1AJBA 1KH4A 1K7HA 4KAYA 3NKOA 4GTXA 4KM4A 2W8DA 4N7TA 3T02A 1EW9A 5GOVA 3WAXA 3MK2A 1KH9A 3CMRA 2W8SA 4LR7A 3DYCA 1P49A 4CXKA 2X98A 3NKMA 1ED8A 5K4PA 1HQAA 3UN5A 1KHNA 2W5XA 5L0BA 1HDHA 3NVLA 3TG0A 4UOOA 2IFYA 4LREA 4ZG6A 3BDHA 3TWZA 5LIAA 2XRGA 4LR9A 2G9YA 1ANJA 1ZEFA 2GSOA 4GTYA 1EW8A 4UPIA 1ED9A 1EW2A 4LQYA 4NWXA 3A52A 1EI6A 2W5WA 4B56A 5LQQA 1N2KA 3NKNA 4MHXA 1AUKA 4MY4A 3M7VA 3WBHA 1O98A 3M8WA 1O99A 4UOPA 1EJJA 2GSUA 2D1GA 4LRAA 1ALKA 3NKRA 3BDGA 4KJGA 5LRNA 1KHKA 3M8YA 1E33P 1E3CP 2QZUA 2ZKTA 4CYRA 3IGYB 3MK1A 4QAXA 4LR2A 1AJDA 1ELXA 3OT9A 2W5RA 2GA3A 5TJ3A 3IGZB 4FDJA 1SHQA 1ALHA 3LXQA 3DPCA 4LRCA 1Y7AA 2ANHA 3UNYA 4CXSA 1ELYA 2W5SA 3IDDA 3UN3A 1N2LA 5L0KA 5GRRA 2VQRA 2W5VA 2RH6A 1KHLA 3B5QA 3WAVA 2GSNA 4LR8A 1KH5A 5IJQA 4CXUA 5EGEA 5DLWA 5IJSA 1B8JA 3MK0A 4KJDA 3BDFA 1ALJA 3T01A 1HJKA 4KAVA 5DLTA 4ZG9A 4FDIA 3M8ZA 2GLQA 3E2DA 4GTZA 1AJAA 4NWJA 5AJ9A 3T00A 4YR1A 3SZYA 3BDGB 4TN0A 4MIVA 3UO0A 2IUCA 4LRFA 1URAA 1ZEDA 3ED4A
chains in the Genus database with same CATH superfamily
2IUCB 1AJCA 3WAYA 3Q3QA 1EQJA 4LRDA 4CYSA 4LRBA 4ZGAA 2W5QA 5LRMA 2W5TA 4UORA 5HRTA 1Y6VA 5KXAA 1KH7A 3KD8A 1ALIA 2XR9A 1ELZA 5DLVA 3WAWA 5EGHA 5L0EA 1E2SP 1E1ZP 1KHJA 4GTWA 3NKPA 4UPLA 1ZEBA 4UPKA 5C66A 4ZG7A 5INHA 1URBA 4UPHA 1ANIA 1FSUA 3SZZA 3TX0A 3UN2A 1SHNA 3NKQA 1AJBA 1KH4A 1K7HA 4KAYA 3NKOA 4GTXA 4KM4A 2W8DA 4N7TA 3T02A 1EW9A 5GOVA 3WAXA 3MK2A 1KH9A 3CMRA 2W8SA 4LR7A 3DYCA 1P49A 4CXKA 2X98A 3NKMA 1ED8A 5K4PA 1HQAA 3UN5A 1KHNA 2W5XA 5L0BA 1HDHA 3NVLA 3TG0A 4UOOA 2IFYA 4LREA 4ZG6A 3BDHA 3TWZA 5LIAA 2XRGA 4LR9A 2G9YA 1ANJA 1ZEFA 2GSOA 4GTYA 1EW8A 4UPIA 1ED9A 1EW2A 4LQYA 4NWXA 3A52A 1EI6A 2W5WA 4B56A 5LQQA 1N2KA 3NKNA 4MHXA 1AUKA 4MY4A 3M7VA 3WBHA 1O98A 3M8WA 1O99A 4UOPA 1EJJA 2GSUA 2D1GA 4LRAA 1ALKA 3NKRA 3BDGA 4KJGA 5LRNA 1KHKA 3M8YA 1E33P 1E3CP 2QZUA 2ZKTA 4CYRA 3IGYB 3MK1A 4QAXA 4LR2A 1AJDA 1ELXA 3OT9A 2W5RA 2GA3A 5TJ3A 3IGZB 4FDJA 1SHQA 1ALHA 3LXQA 3DPCA 4LRCA 1Y7AA 2ANHA 3UNYA 4CXSA 1ELYA 2W5SA 3IDDA 3UN3A 1N2LA 5L0KA 5GRRA 2VQRA 2W5VA 2RH6A 1KHLA 3B5QA 3WAVA 2GSNA 4LR8A 1KH5A 5IJQA 4CXUA 5EGEA 5DLWA 5IJSA 1B8JA 3MK0A 4KJDA 3BDFA 1ALJA 3T01A 1HJKA 4KAVA 5DLTA 4ZG9A 4FDIA 3M8ZA 2GLQA 3E2DA 4GTZA 1AJAA 4NWJA 5AJ9A 3T00A 4YR1A 3SZYA 3BDGB 4TN0A 4MIVA 3UO0A 2IUCA 4LRFA 1URAA 1ZEDA 3ED4A
chains in the Genus database with same CATH topology
2IUCB 1AJCA 3WAYA 3Q3QA 1EQJA 4LRDA 4CYSA 4LRBA 4ZGAA 2W5QA 5LRMA 2W5TA 4UORA 5HRTA 1Y6VA 5KXAA 1KH7A 3KD8A 1ALIA 2XR9A 1ELZA 5DLVA 3WAWA 5EGHA 5L0EA 1E2SP 1E1ZP 1KHJA 4GTWA 3NKPA 4UPLA 1ZEBA 4UPKA 5C66A 4ZG7A 5INHA 1URBA 4UPHA 1ANIA 1FSUA 3SZZA 3TX0A 3UN2A 1SHNA 3NKQA 1AJBA 1KH4A 1K7HA 4KAYA 3NKOA 4GTXA 4KM4A 2W8DA 4N7TA 3T02A 1EW9A 5GOVA 3WAXA 3MK2A 1KH9A 3CMRA 2W8SA 4LR7A 3DYCA 1P49A 4CXKA 2X98A 3NKMA 1ED8A 5K4PA 1HQAA 3UN5A 1KHNA 2W5XA 5L0BA 1HDHA 3NVLA 3TG0A 4UOOA 2IFYA 4LREA 4ZG6A 3BDHA 3TWZA 5LIAA 2XRGA 4LR9A 2G9YA 1ANJA 1ZEFA 2GSOA 4GTYA 1EW8A 4UPIA 1ED9A 1EW2A 4LQYA 4NWXA 3A52A 1EI6A 2W5WA 4B56A 5LQQA 1N2KA 3NKNA 4MHXA 1AUKA 4MY4A 3M7VA 3WBHA 1O98A 3M8WA 1O99A 4UOPA 1EJJA 2GSUA 2D1GA 4LRAA 1ALKA 3NKRA 3BDGA 4KJGA 5LRNA 1KHKA 3M8YA 1E33P 1E3CP 2QZUA 2ZKTA 4CYRA 3IGYB 3MK1A 4QAXA 4LR2A 1AJDA 1ELXA 3OT9A 2W5RA 2GA3A 5TJ3A 3IGZB 4FDJA 1SHQA 1ALHA 3LXQA 3DPCA 4LRCA 1Y7AA 2ANHA 3UNYA 4CXSA 1ELYA 2W5SA 3IDDA 3UN3A 1N2LA 5L0KA 5GRRA 2VQRA 2W5VA 2RH6A 1KHLA 3B5QA 3WAVA 2GSNA 4LR8A 1KH5A 5IJQA 4CXUA 5EGEA 5DLWA 5IJSA 1B8JA 3MK0A 4KJDA 3BDFA 1ALJA 3T01A 1HJKA 4KAVA 5DLTA 4ZG9A 4FDIA 3M8ZA 2GLQA 3E2DA 4GTZA 1AJAA 4NWJA 5AJ9A 3T00A 4YR1A 3SZYA 3BDGB 4TN0A 4MIVA 3UO0A 2IUCA 4LRFA 1URAA 1ZEDA 3ED4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2IUC B;  1AJC A;  3WAY A;  3Q3Q A;  1EQJ A;  4LRD A;  4CYS A;  4LRB A;  4ZGA A;  2W5Q A;  5LRM A;  2W5T A;  4UOR A;  5HRT A;  1Y6V A;  5KXA A;  1KH7 A;  3KD8 A;  1ALI A;  2XR9 A;  1ELZ A;  5DLV A;  3WAW A;  5EGH A;  5L0E A;  1E2S P;  1E1Z P;  1KHJ A;  4GTW A;  3NKP A;  4UPL A;  1ZEB A;  4UPK A;  5C66 A;  4ZG7 A;  5INH A;  1URB A;  4UPH A;  1ANI A;  1FSU A;  3SZZ A;  3TX0 A;  3UN2 A;  1SHN A;  3NKQ A;  1AJB A;  1KH4 A;  1K7H A;  4KAY A;  3NKO A;  4GTX A;  4KM4 A;  2W8D A;  4N7T A;  3T02 A;  1EW9 A;  5GOV A;  3WAX A;  3MK2 A;  1KH9 A;  3CMR A;  2W8S A;  4LR7 A;  3DYC A;  1P49 A;  4CXK A;  2X98 A;  3NKM A;  1ED8 A;  5K4P A;  1HQA A;  3UN5 A;  1KHN A;  2W5X A;  5L0B A;  1HDH A;  3NVL A;  3TG0 A;  4UOO A;  2IFY A;  4LRE A;  4ZG6 A;  3BDH A;  3TWZ A;  5LIA A;  2XRG A;  4LR9 A;  2G9Y A;  1ANJ A;  1ZEF A;  2GSO A;  4GTY A;  1EW8 A;  4UPI A;  1ED9 A;  1EW2 A;  4LQY A;  4NWX A;  3A52 A;  1EI6 A;  2W5W A;  4B56 A;  5LQQ A;  1N2K A;  3NKN A;  4MHX A;  1AUK A;  4MY4 A;  3M7V A;  3WBH A;  1O98 A;  3M8W A;  1O99 A;  4UOP A;  1EJJ A;  2GSU A;  2D1G A;  4LRA A;  1ALK A;  3NKR A;  3BDG A;  4KJG A;  5LRN A;  1KHK A;  3M8Y A;  1E33 P;  1E3C P;  2QZU A;  2ZKT A;  4CYR A;  3IGY B;  3MK1 A;  4QAX A;  4LR2 A;  1AJD A;  1ELX A;  3OT9 A;  2W5R A;  2GA3 A;  5TJ3 A;  3IGZ B;  4FDJ A;  1SHQ A;  1ALH A;  3LXQ A;  3DPC A;  4LRC A;  1Y7A A;  2ANH A;  3UNY A;  4CXS A;  1ELY A;  2W5S A;  3IDD A;  3UN3 A;  1N2L A;  5L0K A;  5GRR A;  2VQR A;  2W5V A;  2RH6 A;  1KHL A;  3B5Q A;  3WAV A;  2GSN A;  4LR8 A;  1KH5 A;  5IJQ A;  4CXU A;  5EGE A;  5DLW A;  5IJS A;  1B8J A;  3MK0 A;  4KJD A;  3BDF A;  1ALJ A;  3T01 A;  1HJK A;  4KAV A;  5DLT A;  4ZG9 A;  4FDI A;  3M8Z A;  2GLQ A;  3E2D A;  4GTZ A;  1AJA A;  4NWJ A;  5AJ9 A;  3T00 A;  4YR1 A;  3SZY A;  3BDG B;  4TN0 A;  4MIV A;  3UO0 A;  2IUC A;  4LRF A;  1URA A;  1ZED A;  3ED4 A; 
#chains in the Genus database with same CATH topology
 2IUC B;  1AJC A;  3WAY A;  3Q3Q A;  1EQJ A;  4LRD A;  4CYS A;  4LRB A;  4ZGA A;  2W5Q A;  5LRM A;  2W5T A;  4UOR A;  5HRT A;  1Y6V A;  5KXA A;  1KH7 A;  3KD8 A;  1ALI A;  2XR9 A;  1ELZ A;  5DLV A;  3WAW A;  5EGH A;  5L0E A;  1E2S P;  1E1Z P;  1KHJ A;  4GTW A;  3NKP A;  4UPL A;  1ZEB A;  4UPK A;  5C66 A;  4ZG7 A;  5INH A;  1URB A;  4UPH A;  1ANI A;  1FSU A;  3SZZ A;  3TX0 A;  3UN2 A;  1SHN A;  3NKQ A;  1AJB A;  1KH4 A;  1K7H A;  4KAY A;  3NKO A;  4GTX A;  4KM4 A;  2W8D A;  4N7T A;  3T02 A;  1EW9 A;  5GOV A;  3WAX A;  3MK2 A;  1KH9 A;  3CMR A;  2W8S A;  4LR7 A;  3DYC A;  1P49 A;  4CXK A;  2X98 A;  3NKM A;  1ED8 A;  5K4P A;  1HQA A;  3UN5 A;  1KHN A;  2W5X A;  5L0B A;  1HDH A;  3NVL A;  3TG0 A;  4UOO A;  2IFY A;  4LRE A;  4ZG6 A;  3BDH A;  3TWZ A;  5LIA A;  2XRG A;  4LR9 A;  2G9Y A;  1ANJ A;  1ZEF A;  2GSO A;  4GTY A;  1EW8 A;  4UPI A;  1ED9 A;  1EW2 A;  4LQY A;  4NWX A;  3A52 A;  1EI6 A;  2W5W A;  4B56 A;  5LQQ A;  1N2K A;  3NKN A;  4MHX A;  1AUK A;  4MY4 A;  3M7V A;  3WBH A;  1O98 A;  3M8W A;  1O99 A;  4UOP A;  1EJJ A;  2GSU A;  2D1G A;  4LRA A;  1ALK A;  3NKR A;  3BDG A;  4KJG A;  5LRN A;  1KHK A;  3M8Y A;  1E33 P;  1E3C P;  2QZU A;  2ZKT A;  4CYR A;  3IGY B;  3MK1 A;  4QAX A;  4LR2 A;  1AJD A;  1ELX A;  3OT9 A;  2W5R A;  2GA3 A;  5TJ3 A;  3IGZ B;  4FDJ A;  1SHQ A;  1ALH A;  3LXQ A;  3DPC A;  4LRC A;  1Y7A A;  2ANH A;  3UNY A;  4CXS A;  1ELY A;  2W5S A;  3IDD A;  3UN3 A;  1N2L A;  5L0K A;  5GRR A;  2VQR A;  2W5V A;  2RH6 A;  1KHL A;  3B5Q A;  3WAV A;  2GSN A;  4LR8 A;  1KH5 A;  5IJQ A;  4CXU A;  5EGE A;  5DLW A;  5IJS A;  1B8J A;  3MK0 A;  4KJD A;  3BDF A;  1ALJ A;  3T01 A;  1HJK A;  4KAV A;  5DLT A;  4ZG9 A;  4FDI A;  3M8Z A;  2GLQ A;  3E2D A;  4GTZ A;  1AJA A;  4NWJ A;  5AJ9 A;  3T00 A;  4YR1 A;  3SZY A;  3BDG B;  4TN0 A;  4MIV A;  3UO0 A;  2IUC A;  4LRF A;  1URA A;  1ZED A;  3ED4 A; 
#chains in the Genus database with same CATH homology
 2IUC B;  1AJC A;  3WAY A;  3Q3Q A;  1EQJ A;  4LRD A;  4CYS A;  4LRB A;  4ZGA A;  2W5Q A;  5LRM A;  2W5T A;  4UOR A;  5HRT A;  1Y6V A;  5KXA A;  1KH7 A;  3KD8 A;  1ALI A;  2XR9 A;  1ELZ A;  5DLV A;  3WAW A;  5EGH A;  5L0E A;  1E2S P;  1E1Z P;  1KHJ A;  4GTW A;  3NKP A;  4UPL A;  1ZEB A;  4UPK A;  5C66 A;  4ZG7 A;  5INH A;  1URB A;  4UPH A;  1ANI A;  1FSU A;  3SZZ A;  3TX0 A;  3UN2 A;  1SHN A;  3NKQ A;  1AJB A;  1KH4 A;  1K7H A;  4KAY A;  3NKO A;  4GTX A;  4KM4 A;  2W8D A;  4N7T A;  3T02 A;  1EW9 A;  5GOV A;  3WAX A;  3MK2 A;  1KH9 A;  3CMR A;  2W8S A;  4LR7 A;  3DYC A;  1P49 A;  4CXK A;  2X98 A;  3NKM A;  1ED8 A;  5K4P A;  1HQA A;  3UN5 A;  1KHN A;  2W5X A;  5L0B A;  1HDH A;  3NVL A;  3TG0 A;  4UOO A;  2IFY A;  4LRE A;  4ZG6 A;  3BDH A;  3TWZ A;  5LIA A;  2XRG A;  4LR9 A;  2G9Y A;  1ANJ A;  1ZEF A;  2GSO A;  4GTY A;  1EW8 A;  4UPI A;  1ED9 A;  1EW2 A;  4LQY A;  4NWX A;  3A52 A;  1EI6 A;  2W5W A;  4B56 A;  5LQQ A;  1N2K A;  3NKN A;  4MHX A;  1AUK A;  4MY4 A;  3M7V A;  3WBH A;  1O98 A;  3M8W A;  1O99 A;  4UOP A;  1EJJ A;  2GSU A;  2D1G A;  4LRA A;  1ALK A;  3NKR A;  3BDG A;  4KJG A;  5LRN A;  1KHK A;  3M8Y A;  1E33 P;  1E3C P;  2QZU A;  2ZKT A;  4CYR A;  3IGY B;  3MK1 A;  4QAX A;  4LR2 A;  1AJD A;  1ELX A;  3OT9 A;  2W5R A;  2GA3 A;  5TJ3 A;  3IGZ B;  4FDJ A;  1SHQ A;  1ALH A;  3LXQ A;  3DPC A;  4LRC A;  1Y7A A;  2ANH A;  3UNY A;  4CXS A;  1ELY A;  2W5S A;  3IDD A;  3UN3 A;  1N2L A;  5L0K A;  5GRR A;  2VQR A;  2W5V A;  2RH6 A;  1KHL A;  3B5Q A;  3WAV A;  2GSN A;  4LR8 A;  1KH5 A;  5IJQ A;  4CXU A;  5EGE A;  5DLW A;  5IJS A;  1B8J A;  3MK0 A;  4KJD A;  3BDF A;  1ALJ A;  3T01 A;  1HJK A;  4KAV A;  5DLT A;  4ZG9 A;  4FDI A;  3M8Z A;  2GLQ A;  3E2D A;  4GTZ A;  1AJA A;  4NWJ A;  5AJ9 A;  3T00 A;  4YR1 A;  3SZY A;  3BDG B;  4TN0 A;  4MIV A;  3UO0 A;  2IUC A;  4LRF A;  1URA A;  1ZED A;  3ED4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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